CN1107056A - Ginseng fuling and root of herbaceous peony oral liquid and preparing technology - Google Patents
Ginseng fuling and root of herbaceous peony oral liquid and preparing technology Download PDFInfo
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- CN1107056A CN1107056A CN 94110743 CN94110743A CN1107056A CN 1107056 A CN1107056 A CN 1107056A CN 94110743 CN94110743 CN 94110743 CN 94110743 A CN94110743 A CN 94110743A CN 1107056 A CN1107056 A CN 1107056A
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Abstract
The invented oral liquid is made from the traditional "shenling baizhu powder" through modern technology. The volatile oils of alcohol extracted ginseng and water distilled rhizome of large-headed atractylodes and grains of paradise are adopted, the other seven traditional Chinese medicines are extracted by decoction. The proper amount of tween-80 and sorbierite are added, then it is finished. Said product features simple and advanced technologies, compared with the original recipe, the advantages are high content of biological active matter, quick curative effect, convenient for taking and saving raw material.
Description
Ginseng fuling and root of herbaceous peony oral liquid and preparation technology thereof.
The present invention is a Chinese medicine novel form.
Ginseng fuling and root of herbaceous peony oral liquid is a kind of Chinese medicine oral liquid according to one of the ancient proved recipe of motherland's medical science works " formulary of peaceful benevolent dispensary " " SHENLING BAISHU SAN " development.Function with tonifying the spleen and stomach, lung benefiting gas.Cure mainly weakness of the spleen and stomach, anorexia and loose stool, breathe hard cough, lassitude of the limbs and weakness etc.Medication before this all is to adopt decoction, powder, pill, being about to the crude drug in whole powder mixes, un-extracted is refining, and its medicinal and non-medicinal ingredient all has, and bioactive substance content is few, so dosage is big, and take inconvenience, absorbance is low, is not fully utilized, the drug effect performance is also slow, causes wave useless and patient's the financial burden and the inconvenience of medication of medical material.
The objective of the invention is to excavate and raising motherland medicine legacy, on the SHENLING BAISHU SAN basis, change dosage form, overcome that the powder bioactive substance content is low, survival dose is big, absorbance is low, drug utilization rate variance, drug effect are slow, take shortcoming such as inconvenience, for clinical provide one safely, be easy to body absorb, effectively, little, the taking convenience of dosage, the Chinese medicine oral liquid that is easy to accept.
The present invention finishes like this:
Dosage forms such as traditional decoction of traditional Chinese medical science tradition name side " SHENLING BAISHU SAN ", powder, pill are changed system into the oral liquid novel form.
Its preparation technology is:
A, Radix Ginseng with alcohol-water flow extract pure aqueous extract, concentrating under reduced pressure removes pure concentrated solution (1) liquid;
B, the Rhizoma Atractylodis Macrocephalae and Fructus Amomi get volatile oil distillate (2) liquid through steam distillation.
C, panaxynol water are proposed medicinal residues, the Rhizoma Atractylodis Macrocephalae and the same Poria of Fructus Amomi steam distillation medicinal residues, Rhizoma Dioscoreae, Semen Lablab Album, Semen Nelumbinis, Semen Coicis, Radix Platycodonis, the decoction of Radix Glycyrrhizae water, and fried liquid is through filtering, and filtrate is concentrated in right amount, with alcohol precipitation, cold preservation, filtering supernatant, decompression removes alcohol, gets concentrated solution (3) liquid;
D, with (1), (3) liquid mixing, add water, stir, leave standstill, filter, add (2) liquid and an amount of tween 80 and sorbic acid in the filtrate, add water and adjust total amount and get dosing, stir evenly, leave standstill, filter fill, sterilization, check.
Radix Ginseng under 70~85 ℃, alcohol reflux.
The consumption that adds tween 80 in the preparation is 0.1~1%, and adding the sorbitol amount is 0.01~0.2%.
The crude drug in whole consumption is Radix Ginseng 0.10g, Semen Lablab Album 0.075g, Semen Nelumbinis 0.05g, Semen Coicis 0.05g, Fructus Amomi 0.05g, Radix Platycodonis 0.05g, Radix Glycyrrhizae 0.10g in the every 1ml oral liquid of prepared oral liquid.
Technology advanced person of the present invention, preparation method is reliable, for pharmaceuticals industry production provides sophisticated technology, has reached the advanced level of domestic like product with the ginseng fuling and root of herbaceous peony oral liquid of this method preparation.Pharmacological evaluation proves, ginseng fuling and root of herbaceous peony oral liquid can obviously suppress the activity of intestinal smooth muscle and antidiarrheal and having is removed the intestinal spasm that acetylcholine and barium chloride cause, and can invigorating the spleen and regulating the stomach, raise immunity.
Embodiment: get Radix Ginseng 10Kg, Poria 10Kg, Rhizoma Atractylodis Macrocephalae 10Kg, Rhizoma Dioscoreae 10Kg, Semen Lablab Album 7.5Kg, Semen Nelumbinis 5.0Kg, Semen Coicis 5.0Kg, Fructus Amomi 5.0Kg, Radix Platycodonis 5.0Kg, Radix Glycyrrhizae 10Kg.
1, Radix Ginseng 10Kg is ground into particulate, add 50% ethanol, 3.5 ten thousand ml, 2.5 ten thousand ml respectively, heating and refluxing extraction secondary (suitably regulating reflux temperature and back-flow velocity), 1.5 hours for the first time, 1 hour for the second time, filter reflux extracting liquid with filter, merge, decompression recycling ethanol makes concentrated solution to syrupy shape, and cold preservation is standby.
2, the Rhizoma Atractylodis Macrocephalae and Fructus Amomi are put distillation collection volatile oil distillate in the water vapour.
3, put in the decoction pot through the medicinal residues after the reflux, extract, and the Rhizoma Atractylodis Macrocephalae and the medicinal residues of Fructus Amomi after distillation altogether with other seven flavor medicines Radix Ginseng, add water 450,000 ml, 32.5ml respectively and decoct secondary, boiling time was respectively 1.5 hours and 1 hour, collected decoction liquor twice, filtered, filtrate is concentrated into syrupy shape, it is an amount of to add ethanol, makes to contain alcohol amount and reach 65%, cold preservation, placement, supernatant liquid filtering, decompression filtrate recycling ethanol to syrupy shape gets concentrated solution.
It is an amount of that 1 and 3 concentrated solution mixings are added water, stirs, leaves standstill filtration, adds 2 volatile oil and distillate in the filtrate, adds an amount of tween 80 and sorbitol again, add water again and make total amount to 10 ten thousand ml, make dosing, filter the filtrate fill, pressure sterilizing, packing, being up to the standards promptly gets ginseng fuling and root of herbaceous peony oral liquid.
Claims (5)
1, ginseng fuling and root of herbaceous peony oral liquid is characterized in that the oral liquid novel form is made by traditional Chinese medical science tradition name side " SHENLING BAISHU SAN ".
2, ginseng fuling and root of herbaceous peony oral liquid as claimed in claim 1, its preparation technology is:
A, Radix Ginseng with alcohol-water flow extract pure aqueous extract, concentrating under reduced pressure removes pure concentrated solution (1) liquid;
B, the Rhizoma Atractylodis Macrocephalae and Fructus Amomi get volatile oil distillate (2) liquid through steam distillation.
C, panaxynol water are proposed medicinal residues, the Rhizoma Atractylodis Macrocephalae and the same Poria of Fructus Amomi steam distillation medicinal residues, Rhizoma Dioscoreae, Semen Lablab Album, Semen Nelumbinis, Semen Coicis, Radix Platycodonis, the decoction of Radix Glycyrrhizae water, and fried liquid is through filtering, and filtrate is concentrated in right amount, with alcohol precipitation, cold preservation, filtering supernatant, decompression removes alcohol, gets concentrated solution (3) liquid;
D, with (1), (3) liquid mixing, add water, stir, leave standstill, filter, add (2) liquid and an amount of tween 80 and sorbic acid in the filtrate, add water and adjust total amount and get dosing, stir evenly, leave standstill, filter, fill, sterilization, inspection is closed
3, according to claim 1 and 2 described ginseng fuling and root of herbaceous peony oral liquid and preparation technologies thereof, it is characterized in that Radix Ginseng under 70~85 ℃, alcohol reflux.
4, according to claim 1 and 2 described ginseng fuling and root of herbaceous peony oral liquid and preparation technologies thereof, the consumption that adds tween 80 in it is characterized in that preparing is 0.1~1%, and adding the sorbitol amount is 0.01~0.2%.
5,, it is characterized in that the crude drug in whole consumption is Radix Ginseng 0.10g, Semen Lablab Album 0.075g Semen Nelumbinis 0.05g, Semen Coicis 0.05g, Fructus Amomi 0.05g, Radix Platycodonis 0.05g, Radix Glycyrrhizae 0.10g in every 1ml oral liquid as claim 1 and 2 described ginseng fuling and root of herbaceous peony oral liquid and preparation technologies thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 94110743 CN1107056A (en) | 1994-08-24 | 1994-08-24 | Ginseng fuling and root of herbaceous peony oral liquid and preparing technology |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN 94110743 CN1107056A (en) | 1994-08-24 | 1994-08-24 | Ginseng fuling and root of herbaceous peony oral liquid and preparing technology |
Publications (1)
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CN1107056A true CN1107056A (en) | 1995-08-23 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 94110743 Pending CN1107056A (en) | 1994-08-24 | 1994-08-24 | Ginseng fuling and root of herbaceous peony oral liquid and preparing technology |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102988864A (en) * | 2009-07-01 | 2013-03-27 | 北京亚东生物制药有限公司 | Shenling Baizhu preparation and novel use thereof |
CN115104689A (en) * | 2021-03-22 | 2022-09-27 | 南京益纤生物科技有限公司 | Solid beverage with intestinal tract adjusting function |
-
1994
- 1994-08-24 CN CN 94110743 patent/CN1107056A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102988864A (en) * | 2009-07-01 | 2013-03-27 | 北京亚东生物制药有限公司 | Shenling Baizhu preparation and novel use thereof |
CN102988864B (en) * | 2009-07-01 | 2015-06-10 | 北京亚东生物制药有限公司 | Shenling Baizhu preparation and novel use thereof |
CN115104689A (en) * | 2021-03-22 | 2022-09-27 | 南京益纤生物科技有限公司 | Solid beverage with intestinal tract adjusting function |
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C01 | Deemed withdrawal of patent application (patent law 1993) | ||
WD01 | Invention patent application deemed withdrawn after publication |