CN110693946A - Formula with bowel relaxing function and preparation method thereof - Google Patents
Formula with bowel relaxing function and preparation method thereof Download PDFInfo
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- CN110693946A CN110693946A CN201911004931.8A CN201911004931A CN110693946A CN 110693946 A CN110693946 A CN 110693946A CN 201911004931 A CN201911004931 A CN 201911004931A CN 110693946 A CN110693946 A CN 110693946A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Mycology (AREA)
- Botany (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention discloses a prescription with the function of relaxing bowel and a preparation method thereof, which is characterized in that: the composition is prepared by combining the common bedded ginseng or common bedded ginseng extract, fructus cannabis or hemp seed oil and pharmaceutically or dietetically acceptable auxiliary materials, and a product taking the composition disclosed by the invention as a main component can moisten intestinal tracts and enhance intestinal peristalsis in a short time, so that the effects of promoting defecation and facilitating defecation are achieved; can balance or restore normal intestinal flora for a long time, has healthy intestinal tracts, and realizes normal defecation without other auxiliary means such as medicaments and the like. The formula has the advantages of wide safe dose range, good effect and wide application range, can be widely applied to long-term constipation people, postoperative or postpartum short-term constipation people and constipation people caused by other diseases, and is a medicament or functional food or food with good development prospect.
Description
Technical Field
The invention belongs to the field of medicine and health care, and particularly relates to a formula for relaxing bowel and a preparation method thereof.
Background
Normal people defecate 1-2 times or 1-2 times every day, while constipation people defecate less than 3 times every week, and defecate labouriously with hard feces and small amount. Constipation is a common symptom in the elderly, and the elderly of about 1/3 suffer constipation, which seriously affects the quality of life of the elderly. The characteristics of fast pace, high pressure, unreasonable dietary structure, little exercise and the like of the modern society lead the basic number of the current constipation crowds to be greatly increased and the constipation to be more younger.
Constipation seems to be a little, but actually has a great influence on health. Constipation can directly cause or enhance anorectal diseases, gastrointestinal nerve dysfunction, and can induce attack of cardiovascular and cerebrovascular diseases, neurasthenia, dysmenorrhea, facial pigmentation, body odor, etc. If the constipation is serious, intestinal cancer can be induced or sudden death can be caused, and data show that about 10 percent of people with severe constipation suffer from colon cancer; for patients with cardiovascular diseases such as hypertension and coronary heart disease, the anal anger caused by severe constipation can cause the blood pressure to rise rapidly, resulting in stroke and even sudden death.
The intestinal tract is not only a normal component of the body and participates in important physiological activities of the body, but also has complex intestinal flora, and plays important roles in the growth, development, health and the like of a host. In particular, many serious diseases such as cardiovascular diseases, tumors, diabetes and the like seem to be unrelated to the spleen, the stomach and the intestine, but the occurrence and the development of the diseases are fundamentally related to the spleen, the stomach and the intestine. The middle jiao of a person is healthy, the balance of the entrance and the exit can be achieved, and the diseases can not be cured or reduced. Therefore, modern health care needs to pay attention to the spleen, stomach and intestinal tract of middle jiao.
There are currently 6 main classes of diarrhea drugs on the market. The types of common constipation are mainly classified into three types: slow transit, outlet obstruction, and mixed. The current commonly used drugs for treating constipation are: bulk laxatives, stimulant laxatives, lubricity laxatives, osmotic laxatives, prokinetic drugs, and 5-HT 4 receptor agonists, among others. 1. Bulk laxatives, also known as epsomites, are not absorbed by the intestinal wall but are soluble in water, and therefore they absorb a large amount of water in the intestine, increasing the volume of the stool and acting as a cathartic. The principal representative of this class of purgative drugs is magnesium sulfate. However, it is not suitable for patients with intestinal hypomotility because it does not increase the colonic tension. 2. Stimulant laxatives have a rapid and powerful action and the drugs or their metabolic products can stimulate the intestinal wall and increase the intestinal motility. The medicine mainly comprises the following components: fruit guide, castor oil, rhubarb, senna leaf and the like. However, it should be noted that these drugs are mainly used for the cases of stool impaction and the need of rapid defecation, and are not suitable for long-term use because they stimulate the intestinal mucosa and the intestinal wall nerve plexus and may cause the weakness of the large intestine to form drug dependence. 3. Lubricity purgatives the lubricity purgatives are also known as stool softeners, which have the main function of lubricating the intestinal wall, softening the stool and facilitating the discharge of stools, such as liquid paraffin. The main disadvantages of the medicines are poor taste and weak action, and poor absorption of fat-soluble vitamins caused by long-term application. 4. Osmotic laxatives such as lactulose, which are not absorbed by the body, act in the colon by releasing organic acids after bacterial breakdown. Is especially suitable for the elderly, pregnant and parturient women, children and postoperative patients with constipation. It should be used with cautions for diabetic patients. The main disadvantage of the medicine is that the medicine is fermented under the action of bacteria to generate gas, which causes discomfort such as abdominal distension and the like. 5. The gut motility drugs act by strengthening gut muscle tone, but often need to be used in combination with other drugs. 6. The 5-HT 4 receptor agonist includes tegaserod, polyethylene glycol, etc., and tegaserod has certain curative effect on constipation-type irritable bowel syndrome, and is especially suitable for patients who have been used osmotic cathartic and have no effect on intestinal cellulose. Polyethylene glycol is not absorbed by intestinal tract, and will not decompose and produce acid in intestinal tract, so it can be used for constipation caused by various reasons of adult. However, it is not suitable for patients with inflammatory organic bowel disease and undiagnosed abdominal pain, and is preferably administered 2 hours apart from other drugs.
The existing constipation medicines or functional foods have the disadvantages of the medicines or the functional foods, and the constipation needs to be cured by comprehensive conditioning, so that the aim is not only to figure 'one time fast', but also to restore the physiological defecation of the user. There is a need for a product that not only can rapidly achieve defecation, but also can achieve intestinal health by regulating the intestinal tract for a long time, restoring physiological defecation.
The local people eat the stinky ginseng stewed with meat or take the powder of the stinky ginseng with warm water for tonifying qi and enriching blood, and the local people are used by a plurality of nationalities such as Tibetan nationality, Yi nationality, white nationality and the like. The Chinese national dictionary records a plurality of varieties of the Chinese medicinal herbs. The health food is mostly eaten as a cheap tonic in Yunnan, has the effects of tonifying qi and generating blood, dredging channels and collaterals and promoting digestion, and is sold in the market in large quantities in each autumn and winter in local places.
At present, a few research reports are carried out on the osbeckia chinensis, and particularly, the pharmacodynamic action mechanism of the osbeckia chinensis is obtained. Several patents are reported about the extraction and separation of active substances of osmyl ginseng. In the aspect of pharmacological research, the applicant researches deeply and finds that the stinky ginseng can enhance intestinal peristalsis, balance or repair intestinal flora and has a good effect on long-term improvement of constipation.
Fructus cannabis, the name of traditional Chinese medicine. Dried mature seed of L. of the Moraceae plant Cannabis sativa. Distributed in northeast, east and south China. Has the effect of relaxing bowel. It is commonly indicated for constipation due to intestinal dryness caused by blood deficiency and fluid deficiency. Huo Ma ren is compounded in the works of "Xiao Fang" (prescription for near effect) and "Yu Fang' (secret essentials of exterior desk) and has no long-term improvement effect even if it is used in a secret way.
After the folk edible foundation of the oblongata and the medicinal efficacy of the fructus cannabis are fully known, the present research results are summarized, the full thinking is provided, and the formula with the function of relaxing bowel is provided, wherein the formula can moisten the intestinal tract and enhance the intestinal peristalsis in a short time, so that the effects of promoting defecation and facilitating defecation are achieved; can balance or restore normal intestinal flora for a long time, has healthy intestinal tracts, and realizes normal defecation without other auxiliary means such as medicaments and the like. The formula has the advantages of wide safe dose range, good effect and wide application range, and can be widely applied to long-term constipation people, postoperative or postpartum short-term constipation people and constipation people caused by other diseases. The formula has good social benefit and market value.
Disclosure of Invention
The invention aims to provide a formula with the function of relaxing bowel and a preparation method thereof.
The invention aims to realize the effect that the prescription with the function of relaxing bowel is prepared by combining the common rue herb or the common rue herb extract with the hemp seed or the hemp seed oil and adding auxiliary materials which are acceptable in terms of medicine or food science.
Wherein the rhizoma cimicifugae is root of a specific plant of Codonopsis genus of Campanulaceae family in southwest of China, especially Yunnan region.
Wherein the osbeckia extract is one or a mixture of more of an aqueous extract, an alcohol extract or other organic solvent extracts, essential oil and fresh root juice of osbeckia root.
Wherein the fructus Cannabis is seed of industrial hemp.
The formula is suitable for people with long-term constipation, people with short-term constipation after or after operation, and people with constipation caused by other diseases.
Wherein the formulation can be made into drugs, functional foods, special dietary foods or conventional foods.
The preparation dosage forms of the medicine comprise injection, oral liquid and suppository.
Wherein the formulation is useful for short-term promotion of defecation; can also be used for treating long-term constipation.
The formula for health care or treatment of intestinal diseases provided by the invention fully exerts the advantages of the stinky ginseng, is beneficial to promoting the further development of the stinky ginseng industry, and has good social and economic benefits.
Detailed Description
The present invention is further illustrated but not limited in any way by the following examples, and any modifications or alterations based on the present invention are within the scope of the present invention.
Example 1
The present embodiment provides a powder for relaxing bowel, which is prepared by the following steps: weighing 100g of dried radix clerodendri bungei, pulverizing, extracting with 500mL of ethanol for three times, mixing, concentrating, passing through a column to remove impurities such as pigment, adding 20g of fructus cannabis dry powder, mixing, filling, packaging, capping, and storing at low temperature.
Example 2
This example provides a tablet suitable for loosening bowel to relieve constipation, the operation is as follows: weighing 100g of clerodendroa cyrtophyllum water extract, 100g of fructus cannabis dry powder, 30g of aloe extract, 355g of starch and 15g of magnesium stearate, uniformly mixing, granulating, drying and tabletting, wherein each tablet is 0.5g in weight, and storing in low-temperature inert gas to obtain the tablet preparation of the invention.
Example 3
This example provides an oral formulation suitable for preventing or delaying or treating intestinal disorders by: weighing 100g of the alcohol extract of the osbeckia chinensis, 80g of the hemp seed oil and 20mL of the rose essential oil, adding the mixture into 500mL of soybean oil, uniformly stirring, sterilizing, and aseptically filling to obtain the osbeckia chinensis.
Example 4
The embodiment provides a health food suitable for relaxing bowel, which is prepared by the following steps: weighing 100g of dried osbeckia chinensis powder, 100g of dried fructus cannabis powder, 300g of starch and 15g of magnesium stearate, uniformly mixing, granulating, drying and tabletting, wherein each tablet is 0.5g in weight, and storing by low-temperature inert gas to obtain the tablet formulation of the invention.
Example 5
The embodiment provides a dropping pill suitable for relaxing bowel, which is prepared by the following steps: weighing 100g of the alcohol extract of the osbeckia chinensis, 100g of the hemp seed oil, 20g of the aloe extract and 500mL of peanut oil, uniformly dispersing, preparing, and storing by low-temperature inert gas to obtain the preparation.
Pharmacodynamic experiments:
defecation indexes drawn up by referring to a chronic constipation rating method in the Chinese medicament clinical research guiding principle are as follows: the defecation interval time index, the stool property index, the defecation labor-wasting index, the abdominal pain index and the abdominal distension index are comprehensively evaluated for constipation crowds according to different levels of the above 5 indexes.
20 people with constipation are selected, n1-n10 is a person with transient constipation after operation (normal defecation before operation), n11-n20 is a person with long-term constipation in the age range of 50-60 years, and the number of people is basically equal. The experiment was carried out with the formulation of example 2. The treatment group was subjected to the formulation administration experiment of example 2, and the control group was administered with a blank tablet. The scores are calculated as average scores.
The results are given in the following table:
remarking: the administration time of the drug is 4 weeks for people with n1-n10 constipation, and 4 months for people with n11-n20 constipation.
Score vs constipation degree relationship:
0-5 min: normal;
6-15 points of: mild;
16-25 min: moderate;
26-35 parts: and (4) heavy.
And (4) conclusion: 1. the composition has rapid therapeutic effect on short-term constipation, and can be used for treating constipation.
2. The composition has slow improving effect on long-term constipation.
3. After the prescription is administrated to the people with long-term constipation to achieve a certain improvement effect, the symptoms are still continuously improved after the prescription is stopped, and the prescription is proved to have a long-term treatment effect on the people with long-term constipation.
Claims (8)
1. A prescription with the function of relaxing bowel and a preparation method thereof are characterized in that: the formula is prepared by combining common sage root or common sage root extract with fructus cannabis or hemp seed oil and adding auxiliary materials acceptable in pharmacy or dietetics.
2. The prescription with the function of relaxing bowel according to claim 1, which is characterized in that: the rhizoma osbeckiae chinensis is root of a specific plant of a plant of codonopsis in Campanulaceae in southwest region of China, especially in Yunnan region.
3. The prescription with the function of relaxing bowel according to claim 1, which is characterized in that: the osbeckia chinensis extract is one or a mixture of more of an aqueous extract, an alcohol extract or other organic solvent extracts, essential oil and fresh root juice of osbeckia chinensis roots.
4. The prescription with the function of relaxing bowel according to claim 1, which is characterized in that: the fructus cannabis is industrial hemp seed.
5. The prescription with the function of relaxing bowel according to claim 1, which is characterized in that: the formula is suitable for long-term constipation people, postoperative or postpartum short-term constipation people and constipation people caused by other diseases.
6. The prescription with the function of relaxing bowel according to claim 1, which is characterized in that: the composition can be made into medicines, functional foods, special dietary foods or conventional foods.
7. The prescription with the function of relaxing bowel according to claim 6, which is characterized in that: the preparation formulation of the medicament comprises injection, oral liquid and suppository.
8. The prescription with the function of relaxing bowel according to claim 1, which is characterized in that: the formula can be used for promoting defecation in a short term and can also be used for treating long-term constipation people.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111202798A (en) * | 2019-11-14 | 2020-05-29 | 河北御芝林药业有限公司 | New application of bowel relaxing formula with five fruits and vegetables as raw materials for increasing intestinal mucus layer and protecting intestinal tract |
| CN112931873A (en) * | 2021-02-24 | 2021-06-11 | 山西宏田嘉利农业科技有限公司 | Novel intestine-lubricating compound oil prepared based on hemp oil |
| CN114259053A (en) * | 2021-12-30 | 2022-04-01 | 新乡绿健园药食同源研究院有限公司 | Fructus cannabis and radix angelicae sinensis soft capsule and preparation method thereof |
-
2019
- 2019-10-22 CN CN201911004931.8A patent/CN110693946A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111202798A (en) * | 2019-11-14 | 2020-05-29 | 河北御芝林药业有限公司 | New application of bowel relaxing formula with five fruits and vegetables as raw materials for increasing intestinal mucus layer and protecting intestinal tract |
| CN112931873A (en) * | 2021-02-24 | 2021-06-11 | 山西宏田嘉利农业科技有限公司 | Novel intestine-lubricating compound oil prepared based on hemp oil |
| CN114259053A (en) * | 2021-12-30 | 2022-04-01 | 新乡绿健园药食同源研究院有限公司 | Fructus cannabis and radix angelicae sinensis soft capsule and preparation method thereof |
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Address after: No. 300, Southwest Forestry University, Panlong District, Kunming, Yunnan 650224 Applicant after: Luan Yunpeng Address before: 650000 No. 141 Chunyu Road, Wuhua District, Kunming City, Yunnan Province Applicant before: Luan Yunpeng |
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Application publication date: 20200117 |