CN110692885A - 一种用于缓解便秘的益生菌保健饮料 - Google Patents
一种用于缓解便秘的益生菌保健饮料 Download PDFInfo
- Publication number
- CN110692885A CN110692885A CN201911106499.3A CN201911106499A CN110692885A CN 110692885 A CN110692885 A CN 110692885A CN 201911106499 A CN201911106499 A CN 201911106499A CN 110692885 A CN110692885 A CN 110692885A
- Authority
- CN
- China
- Prior art keywords
- bifidobacterium
- probiotic
- probiotics
- constipation
- intestinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006041 probiotic Substances 0.000 title claims abstract description 63
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 63
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 40
- 206010010774 Constipation Diseases 0.000 title claims abstract description 36
- 235000013361 beverage Nutrition 0.000 title claims abstract description 25
- 241000186016 Bifidobacterium bifidum Species 0.000 claims abstract description 12
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims abstract description 12
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims abstract description 11
- 241000186012 Bifidobacterium breve Species 0.000 claims abstract description 11
- 240000006024 Lactobacillus plantarum Species 0.000 claims abstract description 11
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims abstract description 11
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims abstract description 11
- 229940009289 bifidobacterium lactis Drugs 0.000 claims abstract description 11
- 229940072205 lactobacillus plantarum Drugs 0.000 claims abstract description 11
- 241001608472 Bifidobacterium longum Species 0.000 claims abstract description 3
- 229940009291 bifidobacterium longum Drugs 0.000 claims abstract description 3
- 230000036541 health Effects 0.000 claims description 22
- 241000186000 Bifidobacterium Species 0.000 claims description 10
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 20
- 230000000968 intestinal effect Effects 0.000 abstract description 12
- 241000894006 Bacteria Species 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 5
- 230000029142 excretion Effects 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 230000013872 defecation Effects 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 230000004600 colonic motility Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229940057917 medium chain triglycerides Drugs 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 201000010538 Lactose Intolerance Diseases 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000112 colonic effect Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000193171 Clostridium butyricum Species 0.000 description 1
- 208000037487 Endotoxemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 229930183167 cerebroside Natural products 0.000 description 1
- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000013367 dietary fats Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000016379 mucosal immune response Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000008521 threonine Nutrition 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000014393 valine Nutrition 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/517—Bifidum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/519—Breve
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种用于缓解便秘的益生菌保健饮料，包括混合益生菌和MCT，所述混合益生菌由长双歧杆菌、两歧双歧杆菌、鼠李糖乳杆菌、植物乳杆菌Lp90、乳双歧杆菌、短双歧杆菌组成，其质量百分比为5‑30%双歧杆菌、5‑30%两歧双歧杆菌、8‑35%鼠李糖乳杆菌、10‑45%植物乳杆菌Lp90、10‑45%乳双歧杆菌%、8‑35%短双歧杆菌。本发明所述益生菌保健饮料，科学的配方配比，通过双向调节肠道的微生态环境与肠道菌群的平衡，促进肠道内益生菌的繁殖，抑制腐败菌的生长，有效改善和预防便秘，增强肠道免疫力，可避免强力排泄给身体带来的损伤。
Description
技术领域
本发明属于益生菌保健品技术领域，具体涉及一种用于缓解便秘的益生菌保健饮料。
背景技术
随着饮食结构的改变及精神和社会压力的增大，便秘已成为困扰现代人的问题之一，严重的影响着人们的生活质量。便秘人群易出现肠道菌群紊乱，长期便秘还会诱发各种疾病。研究表明，各类传统的治疗便秘的药物在临床研究和应用中显现诸多问题。同样通过研究表明，便秘患者同时伴有结肠动力障碍的问题的几率非常大，因此可以说结肠动力障碍是导致便秘的主要原因。结肠动力障碍最常见的表现是结肠排空迟缓，而结肠动力减弱则是这种结肠排空迟缓的主要原因。由于肠内容物在结肠滞留时间过长，水分过度吸收，粪便干结，加重了排便困难。而长期的便秘本身也可导致或者加重肠道菌群紊乱。并且随着医药科学的突飞发展，广谱和强力的抗菌素被广泛应用于治疗各种疾病，使人体肠道内正常的菌群平衡受到不同程度的破坏，肠道内益生菌菌数的多少成了衡量人体健康与否的指标之一。
益生菌是一类对宿主有益的活性微生物，益生菌是近几年研究比较多的肠道微生态调整产品，是定植于人体肠道、生殖系统内，能产生确切健康功效从而改善宿主微生态平衡、发挥有益作用的活性有益微生物的总称。目前世界上研究的功能最强大的产品主要是以上各类微生物组成的复合活性益生菌，其广泛应用于生物工程、工农业、食品安全以及生命健康领域。对人体有益的益生菌大概有十几种，主要有：酪酸梭菌、乳酸菌、双歧杆菌、嗜酸乳杆菌、放线菌、酵母菌等。益生菌的功效：预防或改善腹泻；缓解不耐乳糖症状；预防阴道感染；增强人体免疫力；促进肠道消化系统健康；降低血清胆固醇。
发明内容
针对现有技术中的不足之处，本发明提供一种用于缓解便秘的益生菌保健饮料。
为了达到上述目的，本发明技术方案如下：
一种用于缓解便秘的益生菌保健饮料，包括混合益生菌和MCT，所述混合益生菌由长双歧杆菌、两歧双歧杆菌、鼠李糖乳杆菌、植物乳杆菌Lp90、乳双歧杆菌、短双歧杆菌组成，其质量百分比为5-30%双歧杆菌、5-30%两歧双歧杆菌、8-35%鼠李糖乳杆菌、10-45%植物乳杆菌Lp90、10-45%乳双歧杆菌%、8-35%短双歧杆菌。
进一步的，所述混合益生菌中各组成菌群的质量百分比为10%双歧杆菌、10%两歧双歧杆菌、15%鼠李糖乳杆菌、25%植物乳杆菌Lp90、25%乳双歧杆菌、15%短双歧杆菌。
进一步的，所述混合益生菌活菌量为（2~3）×1010 CFU/g。
进一步的，所述混合益生菌和MCT的质量比为（0.75 - 1）:10。作为优选，质量比为0.8167:10。
进一步的，所述益生菌保健饮料每10mL中含有10gMCT。
本发明的原料：
（1）双歧杆菌：可以维护肠道正常细菌菌群平衡，抑制病原菌的生长，防止便秘，下痢和胃肠障碍等；抗肿瘤；在肠道内合成维生素、氨基酸和提高机体对钙离子的吸收；降低血液中胆固醇水平，防治高血压；改善乳制品的耐乳糖性，提高消化率；增强人体免疫机能，预防抗生素的副作用，抗衰老，延年益寿；增强机体的非特异和特异性免疫反应；控制内毒素血症的作用；提高宿主对放射线的耐受性；
（2）两歧双歧杆菌：两岐双歧杆菌在人体肠内发酵后可产生乳酸和醋酸，能提高钙、磷、铁的利用率，促进铁和维生素D的吸收。双歧杆菌发酵乳糖产生半乳糖，是构成脑神经系统中脑苷脂的成分，与婴儿出生后脑的迅速生长有密切关系。双歧杆菌可以产生维生素B1、B2、B6、B12及丙氨酸、缬氨酸、天冬氨酸和苏氨酸等人体必需的营养物质；
（3）鼠李糖乳杆菌：具有高效降胆固醇，促进细胞分裂，可起到调节肠道菌群、预防和治疗腹泻、排除毒素、预防龋齿、提高机体免疫力及抗癌等重要的生理保健功能；
（4）植物乳杆菌：具有很多的保健作用，如：有一定的免疫调节作用；对致病菌有抑制作用；降低血清胆固醇含量和预防心血管疾病；维持肠道内菌群平衡；促进营养物质吸收；缓解乳糖不耐症；抑制肿瘤细胞的形成等；
（5）乳双歧杆菌：可以通过调整肠道菌群，并通过产生乙酸、乳酸等短链脂肪酸来抑制肠道腐败菌的生长和有毒代谢产物的形成，刺激肠蠕动，从而减少水分的过度吸收而缓解便秘症状；可通过调整肠道正常菌群，抑制肠道许多腐败菌生长，从而减少一些肠源性致癌物的产生；
（6）短双歧杆菌：可以保护肠道黏膜，维持和增强肠道黏膜屏障，促进肠上皮细胞的分化和增殖；可以维持肠道免疫稳定，维持黏膜免疫应答的稳定状态，促进出生后肠道黏膜免疫系统和全身免疫系统的发育成熟，并且通过抑制肠道黏膜过度生成炎症因子降低系统全身性免疫应答反应；有助于肠道菌群的恢复，有效缓对治疗与预防腹泻、便秘均起到作用；
（7）MCT：是中链甘油三酯（Medium Chain Triglycerides）的简称，是由碳链长度6-12的饱和中链脂肪酸组成的甘油三酯。医药行业中常用作溶剂、载体和乳化剂，也可以作为食品行业中香精、色素和维生素的溶剂，其具有不易被胃酸分解，易在肠道中水解的特性。天然存在于棕榈仁油、椰子油等食品和母乳中，是膳食脂肪的来源之一。作为食品添加剂，中链甘油三酯仅由饱和脂肪酸构成，凝固点低，室温下为液体，粘度小。与大豆油比较，完全是无臭、无色的透明液体。与普通的油脂和氢化油脂相比，中链甘油三酯不饱和脂肪酸的含量极低，氧化稳定性非常好，其碘值不超过0.5，MCT在高温和低温下特别稳定。
有益效果：本发明所述益生菌保健饮料，科学的配方配比，通过双向调节肠道的微生态环境与肠道菌群的平衡，促进肠道内益生菌的繁殖，抑制腐败菌的生长，有效改善和预防便秘，增强肠道免疫力，可避免强力排泄给身体带来的损伤，避免吃药的苦楚和副作用，价格适宜，服用方便，适用于日常的肠道健康护理。
具体实施方式
以下参照具体的实施例来说明本发明。本领域技术人员能够理解，这些实施例仅用于说明本发明，其不以任何方式限制本发明的范围。
实施例1
一种用于缓解便秘的益生菌保健饮料，每10mL的益生菌保健饮料中含有10gMCT和0.8167g混合益生菌；混合益生菌由10%双歧杆菌、10%两歧双歧杆菌、15%鼠李糖乳杆菌、25%植物乳杆菌Lp90、25%乳双歧杆菌、15%短双歧杆菌组成。
实施例2
一种用于缓解便秘的益生菌保健饮料，每10mL的益生菌保健饮料中含有10gMCT和0.8167g混合益生菌；混合益生菌由5%双歧杆菌、5%两歧双歧杆菌、8%鼠李糖乳杆菌、37%植物乳杆菌Lp90、37%乳双歧杆菌、8%短双歧杆菌组成。
实施例3
一种用于缓解便秘的益生菌保健饮料，每10mL的益生菌保健饮料中含有10gMCT和0.8167g混合益生菌；混合益生菌由30%双歧杆菌、30%两歧双歧杆菌、10%鼠李糖乳杆菌、10%植物乳杆菌Lp90、10%乳双歧杆菌、10%短双歧杆菌组成。
实施例4
一种用于缓解便秘的益生菌保健饮料，每10mL的益生菌保健饮料中含有10gMCT和0.8167g混合益生菌；混合益生菌由5%双歧杆菌、5%两歧双歧杆菌、35%鼠李糖乳杆菌、10%植物乳杆菌Lp90、10%乳双歧杆菌、35%短双歧杆菌组成。
1. 益生菌保健饮料中活菌数检测
检测方法：采用平板计数法对总活菌数进行检测；并以普通市售的益生菌保健饮料作对比例。检测结果：见表1。
表1
从表1中可以看出在本发明提供的质量配比范围内的益生菌保健饮料（实施例1至4），其活菌数可以达到2×1010CFU/g，而普通市售的益生菌保健饮料(对比例)，其活菌数为3.9×107CFU/g。可见本发明提供的复合益生菌大大增加了益生菌的活菌总数，有效降低了益生菌发挥作用所用的时间，从而能够有效改善便秘等胃肠道疾病。
2. 便秘改善效果评价
观察样本：选择习惯性便秘人群200人，男女各100人，分成2组，一组为实验组，一组为对照组，其中每组中10岁以下10人，11-30岁20人，31-60岁30人，61-80岁20人，81岁以上20人。符合便秘罗马Ⅲ标准；病程最少一个月；近一周内未服用影响胃肠道动力药物；诊断IBS依据不足；结肠镜或结肠造影检查排除肠道器质性病变及由全身性疾病引起的便秘；近三月满足以下两项或两项以上症状：①至少25%的排便感到费力②至少25%的排便为干球状便或硬便③至少25%的排便有不尽感④至少25%的排便有肛门直肠的阻塞感⑤排便次数每周少于3次。
评价方法：受试人群在保持其原有的生活、作息习惯等的情况下，服用实施例1至4制成的益生菌保健饮料，对照组服用上述普通益生菌保健饮料。统计并记录反馈的数据。服用方法:一天三次，一次10mL。测其使用后的情况，周期为四周。
评价标准：连续每天一次到三次排便，判定为便秘改善，使用四周的便秘改善率为从开始服用后第一次排便后连续每天排便1-3次的人数占该组总受试人数的比例。评价结果：见表2。
表2
从表2中可以看出，实验组在使用一周之后便秘便有了明显改善，经过两周、三周改善率明显提高，四周后改善都超过93%。而对照组在没有服用复合益生菌的情况下与改善缓慢。
Claims (6)
1.一种用于缓解便秘的益生菌保健饮料，其特征在于：包括混合益生菌和MCT，所述混合益生菌由长双歧杆菌、两歧双歧杆菌、鼠李糖乳杆菌、植物乳杆菌Lp90、乳双歧杆菌、短双歧杆菌组成，其质量百分比为5-30%双歧杆菌、5-30%两歧双歧杆菌、8-35%鼠李糖乳杆菌、10-45%植物乳杆菌Lp90、10-45%乳双歧杆菌%、8-35%短双歧杆菌。
2.如权利要求1所述的用于缓解便秘的益生菌保健饮料，其特征在于，所述混合益生菌中各组成菌群的质量百分比为10%双歧杆菌、10%两歧双歧杆菌、15%鼠李糖乳杆菌、25%植物乳杆菌Lp90、25%乳双歧杆菌、15%短双歧杆菌。
3.如权利要求1所述的用于缓解便秘的益生菌保健饮料，其特征在于，所述混合益生菌活菌量为（2~3）×1010 CFU/g。
4.如权利要求1所述的用于缓解便秘的益生菌保健饮料，其特征在于，所述混合益生菌和MCT的质量比为（0.75 - 1）:10。
5.如权利要求4所述的用于缓解便秘的益生菌保健饮料，其特征在于，所述混合益生菌和MCT的质量比为0.8167:10。
6.如权利要求1所述的用于缓解便秘的益生菌保健饮料，其特征在于，所述益生菌保健饮料每10mL中含有10gMCT。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911106499.3A CN110692885A (zh) | 2019-11-13 | 2019-11-13 | 一种用于缓解便秘的益生菌保健饮料 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911106499.3A CN110692885A (zh) | 2019-11-13 | 2019-11-13 | 一种用于缓解便秘的益生菌保健饮料 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110692885A true CN110692885A (zh) | 2020-01-17 |
Family
ID=69205255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911106499.3A Pending CN110692885A (zh) | 2019-11-13 | 2019-11-13 | 一种用于缓解便秘的益生菌保健饮料 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110692885A (zh) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111587975A (zh) * | 2020-04-11 | 2020-08-28 | 孙源阔 | 一种改善便秘症状的固体饮料 |
| CN112237287A (zh) * | 2020-11-26 | 2021-01-19 | 河北一然生物科技有限公司 | 一株能够缓解便秘的鼠李糖乳杆菌lr519及其组合物 |
| CN112655800A (zh) * | 2020-12-21 | 2021-04-16 | 上海诺德生物实业有限公司 | 一种含茶叶茶氨酸益生菌的巧克力及其制备方法 |
| CN113615838A (zh) * | 2020-05-06 | 2021-11-09 | 宏浚实业有限公司 | 用于改善胃肠道健康的益生菌复合物 |
| CN113713080A (zh) * | 2021-07-09 | 2021-11-30 | 武汉自然萃创新科技有限公司 | 一种益生菌蜂蜜露 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107115364A (zh) * | 2017-04-22 | 2017-09-01 | 北京市永康年健康科技有限责任公司 | 一种复合益生菌及其制备方法 |
| CN109069551A (zh) * | 2015-12-22 | 2018-12-21 | 罗尔米健康及个人护理有限公司 | 益生菌组合物及其用途 |
| CN109223833A (zh) * | 2017-07-10 | 2019-01-18 | 上海立龙生物科技有限公司 | 一种预防和改善肥胖的益生菌组合物 |
-
2019
- 2019-11-13 CN CN201911106499.3A patent/CN110692885A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069551A (zh) * | 2015-12-22 | 2018-12-21 | 罗尔米健康及个人护理有限公司 | 益生菌组合物及其用途 |
| CN107115364A (zh) * | 2017-04-22 | 2017-09-01 | 北京市永康年健康科技有限责任公司 | 一种复合益生菌及其制备方法 |
| CN109223833A (zh) * | 2017-07-10 | 2019-01-18 | 上海立龙生物科技有限公司 | 一种预防和改善肥胖的益生菌组合物 |
Non-Patent Citations (4)
| Title |
|---|
| 彤博士婴童食品: "新品上市|彤博士复合益生菌凝胶糖果，专利产品，多国联合研发，带你体验一场美妙的咀嚼之旅！", 《孕婴童招商网HTTP://WWW.1288.TV/NEWS/141658.HTML》 * |
| 方曙光: "干货‘2019生物发酵与营养健康•益生制品产业发展高峰论坛’专题报告：益生菌与慢性疾病健康管理", 《微康益生菌HTTPS://MP.WEIXIN.QQ.COM/S/UECPZORHYU6O-F9EJKQD9Q》 * |
| 梅奥营养（广西）卢绍欣: "梅奥MAYO营养滴剂系列简介", 《美篇HTTPS://WWW.MEIPIAN.CN/2EQIT8FF》 * |
| 王兴鹏主编: "《肠道屏障功能障碍：基础与临床》", 30 June 2006, 第二军医大学出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111587975A (zh) * | 2020-04-11 | 2020-08-28 | 孙源阔 | 一种改善便秘症状的固体饮料 |
| CN113615838A (zh) * | 2020-05-06 | 2021-11-09 | 宏浚实业有限公司 | 用于改善胃肠道健康的益生菌复合物 |
| CN112237287A (zh) * | 2020-11-26 | 2021-01-19 | 河北一然生物科技有限公司 | 一株能够缓解便秘的鼠李糖乳杆菌lr519及其组合物 |
| CN112237287B (zh) * | 2020-11-26 | 2022-11-29 | 河北一然生物科技股份有限公司 | 一株能够缓解便秘的鼠李糖乳杆菌lr519及其组合物 |
| CN112655800A (zh) * | 2020-12-21 | 2021-04-16 | 上海诺德生物实业有限公司 | 一种含茶叶茶氨酸益生菌的巧克力及其制备方法 |
| CN113713080A (zh) * | 2021-07-09 | 2021-11-30 | 武汉自然萃创新科技有限公司 | 一种益生菌蜂蜜露 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110692885A (zh) | 一种用于缓解便秘的益生菌保健饮料 | |
| US7901925B2 (en) | Lactobacillus delbrueckii ssp. bulgaricus strain and compositions | |
| JP4455333B2 (ja) | プロバイオティック細菌：Ｌａｃｔｏｂａｃｉｌｌｕｓｆｅｒｍｅｎｔｕｍ | |
| Losada et al. | Towards a healthier diet for the colon: the influence of fructooligosaccharides and lactobacilli on intestinal health | |
| USRE39876E1 (en) | Kit with enteral dietary composition consisting of Streptococcus thermophilus, Bifidobacterium infantis and Bifidobacterium longum | |
| TWI463986B (zh) | 胚芽乳酸桿菌ｃｍｕ９９５菌株之新用途 | |
| CN112716982B (zh) | 含乳酸菌的组合物及其用途 | |
| JP2000175615A (ja) | シンバイオティック機能性食品 | |
| CN113180109A (zh) | 罗伊氏乳杆菌在制备预防或治疗发育障碍类疾病产品中的应用 | |
| CN104415060A (zh) | 可食用组合物及其制备方法和用途 | |
| Kolida et al. | Gastrointestinal microflora: probiotics | |
| JP5592640B2 (ja) | 乳酸菌発酵ローヤルゼリーを含有する抗ストレス剤、その製造方法、視床下部−下垂体−副腎皮質系の活動抑制剤、及び交感神経−副腎髄質系の活動抑制剤 | |
| CN112210516B (zh) | 一种具有肠道调节功能的瑞士乳杆菌l1258及其组合物 | |
| JP2013040186A (ja) | 消化器疾患に関連する症状の緩和に使用されるプロバイオティクス | |
| CN111254088A (zh) | 一种凝结芽孢杆菌菌株及其应用 | |
| CN112980725A (zh) | 一种乳双歧杆菌及其在促进儿童青少年生长发育中的用途 | |
| CN113750113B (zh) | 一种益生菌和益生元的组合物及其应用 | |
| CN110771766A (zh) | 用于儿童肠绞痛、腹泻、修复肠道的益生菌保健饮料 | |
| US9826766B2 (en) | Use of polysaccharides for the intestinal well-being of nursing infants and/or infants | |
| WO2008002484A2 (en) | Novel lactobacillus bulgaricus strain and compositions | |
| Arora et al. | Therapeutic potential of probiotics: A ray of hope or nightmare? | |
| US20070298018A1 (en) | Novel lactobacillus bulgaricus strain and compositions | |
| Georgieva et al. | Probiotics: past, present, and future challenges | |
| CN106974939B (zh) | 厚壁菌类益生菌在治疗和预防肥胖及其相关疾病中的应用 | |
| CN106974940B (zh) | 厚壁菌类益生菌在治疗和预防肥胖及其相关疾病中的应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200117 |