CN1106682A

CN1106682A - Chinese herbs preparation for treatment of vaginitis and venereal disease

Info

Publication number: CN1106682A
Application number: CN 94111242
Authority: CN
Inventors: 蔡惠明; 俞正威
Original assignee: Individual
Current assignee: Individual
Priority date: 1994-02-05
Filing date: 1994-02-05
Publication date: 1995-08-16

Abstract

The Chinese medicine prepn is prepared with natural indigo, honeysuckle, giant Knotweed, cnidium monnieri, garlic oil, picklyash, alumen, borneol, etc. and through the technological processes including shredding, reflux extraction, impurity removing, dilution, etc. It can Kill vaginal trichomonasatis, monilia albicans, coccus gonorrhoeae, chlamydia and syphilis spirochaeta and destroy surface antigen of AlDs virus. Therefore, it has obvious curative effect on vaginitis and venereal diseases.

Description

Chinese herbs preparation for treatment of vaginitis and venereal disease

What the present invention relates to is a kind of Chinese medicine preparation that is used for the treatment of female vagina and common venereal diseases prevention.

At present, female vagina is one of higher common disease of sickness rate in the world, and especially developing country's sickness rate is higher.It mainly comprises two big classes such as candida albicans vaginitis and trichomonal vaginitis.Also quite high at China's female vagina sickness rate, show that according to the statistics of relevant department China married woman vaginitis sickness rate is up to 95%.Treatment to female vagina mainly relies on chemotherapys such as antibiotic clinically, but use antibiotic that organs such as liver, kidney and nerve are had certain toxic and side effects, normal epidermal tissue there is certain zest, can cause or increase the weight of multiple ulcer, also can influence the vagina normal flora and cause its destruction, easily cause the cross infection of vagina, urethra, anus the vagina self-cleaning action.

On the other hand, sexually transmitted disease (STD) is also in rising trend at the sickness rate of China in recent years, and its main source of disease body has gonococcus, treponema pallidum, chlamydia, HIV (human immunodeficiency virus) etc.Existing vaginitis of multilist and sexually transmitted disease (STD) are concurrent clinically, and its result is bigger to the damaging effect of human body.At present, research and development has the medicine of treatment vaginitis and prevention of STD concurrently from the natural resources of Chinese medicinal materials of China's abundant, is paid much attention to day by day, has also developed some and has been used for the Chinese patent medicine of this respect disease treatment and prevention.As Chinese medicine preparation such as " JIEERYIN ", " Clean Living are pure ", use just clinically, and obtain better effects.But this class medicine generally all is to make preparation in order to the Chinese herbal medicine extractum of treatment chronic vaginitis for many years with Rhizoma Coptidis, the Radix Astragali, Cortex Phellodendri, Radix Angelicae Sinensis, Folium Isatidis etc.Its main weakness is that action intensity is not enough, also must be aided with the chemical agent partner treatment in clinical practice, and to improve curative effect, this has just brought stimulation and the toxic and side effects of chemical agent to human normal tissue.

The purpose of this invention is to provide a kind of Chinese medicine preparation, it has the activity of killing of treatment female vagina and common venereal diseases source of disease body, and the curative effect height must not used the chemicals auxiliary treatment, and is low to the zest of human normal tissue.

The objective of the invention is to be achieved through the following technical solutions:

It is 2～20% Indigo Naturalis that the present invention comprises percentage by weight, 2～20% Flos Lonicerae, 2～20% Rhizoma Polygoni Cuspidati, 2～20% Fructus Cnidii, 2～20% the Radix Stemonae, 2～20% Rhizoma Smilacis Glabrae, 2～20% Cortex Hibisci, 2～20% Cortex Dictamni, 2～20% Radix Et Rhizoma Rhei, 2～20% Aloe, 0～15% Pericarpium Zanthoxyli, 0～15% Oleum Bulbus Allii, 0～10% dried Alumen, 0～10% Borneolum Syntheticum, with ten clean, the choppings of Chinese medicine simply except that dried Alumen, Borneolum Syntheticum and Oleum Bulbus Allii in the above-mentioned weight percent component, insert in the apparatus,Soxhlet's, the alcohol reflux with 95% three times merges gained ethanol liquid.Add suitable quantity of water in gained ethanol liquid, jolting is left standstill, and removes precipitated impurities, and above-mentioned roguing process repeats three times.The gained solution decompression is recycled to dried, former medicine extractum.Again the dried Alumen in the above-mentioned weight percent component, Borneolum Syntheticum and Oleum Bulbus Allii are added, weigh.Volume ratio is 1: 30 ratio adding distilled water diluting dissolving by weight, is Chinese medicine preparation of the present invention.

Advantage of the present invention is to trichomonal vaginitis, Candida albicans, gonococcus, treponema pallidum, and chlamydial killing action is strong.And can destroy the surface antigen of HIV (human immunodeficiency virus), and non-stimulated to skin, have no side effect.

Below in conjunction with embodiment advantage of the present invention is described further: get the Indigo Naturalis 7.6% in the aforementioned techniques solution by weight percentage, Flos Lonicerae 7.6%, Rhizoma Polygoni Cuspidati 7.6%, Fructus Cnidii 11.3%, the Radix Stemonae 3.8%, Rhizoma Smilacis Glabrae 11.3%, Cortex Hibisci 11.3%, Cortex Dictamni 11.3%, Radix Et Rhizoma Rhei 11.3%, Aloe 11.3%, Pericarpium Zanthoxyli 3.8%, Oleum Bulbus Allii 0.5%, dried Alumen 0.8%, Borneolum Syntheticum 0.5% is made Chinese medicine preparation A by the preparation method in the aforementioned techniques solution with it.Said preparation A is carried out pharmacodynamics to be detected.Its testing result is as follows:

1. when said preparation A being diluted 100 times, in 2 minutes, kill trichomonal vaginitis;

2. when said preparation A being diluted 50 times, in 1 minute, kill Candida albicans;

3. when said preparation A being diluted 100 times, in 1 minute, kill gonococcus; When diluting 200 times, in 2 minutes, kill gonococcus;

4. when said preparation A being diluted 32 times, at 2 minutes inside brake treponema pallidums;

5. when preparation A being diluted 600 times, in 2 minutes, kill chlamydia;

6. said preparation A can destroy the surface antigen of HIV (human immunodeficiency virus).

Said preparation A is carried out the skin irritation test:

Get rabbit and shave hair, said preparation A is induced and excite contact test, viewing test rabbit after 24 hours and 48 hours, all loseing skin has phenomenons such as erythema and edema, with the negative control group zero difference.The result shows that said preparation A is bordering on zero to dermoreaction intensity, does not promptly have skin allergic reaction.

Above-mentioned detection and result of the test show, Chinese medicine preparation of the present invention is not adding under the chemicals condition, to trichomonal vaginitis, Candida albicans, gonococcus, treponema pallidum, chlamydia have very strong killing action, and can destroy the surface antigen of HIV (human immunodeficiency virus).Therefore the therapeutical effect to vaginitis and common venereal diseases is significant, and non-stimulated to skin.

Claims

1, a kind of Chinese medicine preparation that is used for the treatment of female vagina and common venereal diseases prevention, it is characterized in that it comprises the weight percent component is 2～20% Indigo Naturalis, 2～20% Flos Lonicerae, 2～20% Rhizoma Polygoni Cuspidati, 2～20% Fructus Cnidii, 2～20% the Radix Stemonae, 2～20% Rhizoma Smilacis Glabrae, 2～20% Cortex Hibisci, 2～20% Cortex Dictamni, 2～20% Radix Et Rhizoma Rhei, 2～20% Aloe, 0～15% Oleum Bulbus Allii, 0～15% Pericarpium Zanthoxyli, 0～15% dried Alumen, 0～10% Borneolum Syntheticum, dried Alumen will be removed in the above-mentioned weight percent component, beyond Borneolum Syntheticum and the Oleum Bulbus Allii all the other ten simply Chinese medicine clean, chopping, insert in the apparatus,Soxhlet's, alcohol reflux with 95% 3 times, merge gained ethanol liquid, in gained ethanol liquid, add suitable quantity of water, jolting, leave standstill, remove precipitated impurities, above-mentioned roguing process repeats three times, be recycled to the gained solution decompression dried, get former medicine extractum, again with the dried Alumen in the above-mentioned weight percent component, Borneolum Syntheticum and Oleum Bulbus Allii add, weigh, volume ratio is 1: 30 a ratio adding distilled water by weight, dilution, dissolving makes.

2, a kind of Chinese medicine preparation as claimed in claim 1, it is characterized in that it comprises the weight percent component respectively is 7.6% Indigo Naturalis, Flos Lonicerae, Rhizoma Polygoni Cuspidati, the weight percent component respectively is 11.3% Fructus Cnidii, Rhizoma Smilacis Glabrae, Cortex Hibisci, Cortex Dictamni, Radix Et Rhizoma Rhei, Aloe, the weight percent component respectively is 3.8% the Radix Stemonae, Pericarpium Zanthoxyli and weight percent component respectively are 0.5% Oleum Bulbus Allii and Borneolum Syntheticum, 0.8% dried Alumen, dried Alumen will be removed in the above-mentioned weight percent component, beyond Borneolum Syntheticum and the Oleum Bulbus Allii all the other ten simply Chinese medicine clean, chopping, place apparatus,Soxhlet's, alcohol reflux with 95% three times merges gained ethanol liquid, adds suitable quantity of water in gained ethanol liquid, jolting, leave standstill, remove precipitated impurities, above-mentioned roguing process repeats three times, be recycled to the gained solution decompression dried, get former medicine extractum, again with the dried Alumen in the above-mentioned weight percent component, Borneolum Syntheticum and Oleum Bulbus Allii add, and weigh, volume ratio is 1: 30 a ratio adding distilled water by weight, dilution, dissolving makes.