CN108273118A - Chinese medicine antibacterial sanitary napkin containing graphene oxide-copper silver nanoparticle compound - Google Patents

Chinese medicine antibacterial sanitary napkin containing graphene oxide-copper silver nanoparticle compound Download PDF

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Publication number
CN108273118A
CN108273118A CN201810211434.4A CN201810211434A CN108273118A CN 108273118 A CN108273118 A CN 108273118A CN 201810211434 A CN201810211434 A CN 201810211434A CN 108273118 A CN108273118 A CN 108273118A
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parts
graphene oxide
silver nanoparticle
copper silver
sanitary napkin
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赵立春
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Guangxi University of Chinese Medicine
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Guangxi University of Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/46Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/34Copper; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/38Silver; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/07Basidiomycota, e.g. Cryptococcus
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    • A61K36/11Pteridophyta or Filicophyta (ferns)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/532Agastache, e.g. giant hyssop
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    • A61K36/533Leonurus (motherwort)
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738Rosa (rose)
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • AHUMAN NECESSITIES
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    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104Silver, e.g. silver sulfadiazine
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/108Elemental carbon, e.g. charcoal
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    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45Mixtures of two or more drugs, e.g. synergistic mixtures

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Abstract

The present invention proposes a kind of Chinese medicine antibacterial sanitary napkin of the silver nanoparticle of copper containing graphene oxide compound, and antiseptic anti-inflammatory has been sprayed in sanitary napkin endosexine, and the raw material for preparing of the liquid includes:Graphene oxide copper silver nanoparticle compound, radix scutellariae, Fructus Forsythiae, Chinese gall, Lasiosphaera fenzlii, cloves, wrinkled giant hyssop, folium artemisiae argyi, motherwort, rose, China rose, red halloysite, the root of bidentate achyranthes, cockscomb, pyrrosia lingua, akebi, field thistle.The bacteria-inhibiting type sanitary napkin of the present invention, it is effectively antibacterial, it is non-stimulated to skin, it is without side-effects, and the improvement of vagina inflammation is can aid in, protect women's health.

Description

Chinese medicine antibacterial sanitary napkin containing graphene oxide-copper silver nanoparticle compound
Technical field
The present invention relates to a kind of feminine hygiene articles more particularly to a kind of Chinese medicine antibacterial sanitary napkins.
Background technology
Sanitary napkin is a kind of substance of tool absorbability, and main material is cotton, nonwoven fabric, paper pulp or more material compound It is formed by high molecular polymer and high molecular polymer extrusion coating paper, the design of side is mainly used to prevent side leakage, cotton wool Gum is waterproof material, and menses can be retained in cotton wool, carrys out the time of tide for absorbing feminine menstrual, the warp flowed out from vagina Blood.The sanitation and hygiene of catamenial products are especially important, because pelvic cavity, uterus, uterine neck, vagina, vitro all communicate, in this way Structure make the reproductive system of women be particularly easy to be invaded by extraneous causative agent, such as bacterium, virus, especially menstrual period Between, resistance declines, if having used underproof sanitary napkin, is particularly easy to infect.
Modern research shows that graphene oxide-copper argentum nano composite material all shows significant resist to various pathogen Bacterium, bacteriostatic activity.Graphene oxide-copper argentum nano composite material is added in natural harmless Chinese medicine antibacterial composition, no The activity for improving only antibacterial anti-inflammatory, the effect have clear improvement to the problems such as vagina itch, leukorrhea peculiar smell, vaginitis Fruit is free from side effects simultaneously so that even if women can also be safe to use in menstrual period.Therefore, by graphene oxide-copper silver nanoparticle Compound and Traditional Chinese medicine bacteriostatic composition, which are applied to the effect for increasing antibacterial anti-inflammatory in sanitary napkin, has good application prospect.
Invention content
In order to solve the above technical problems, the present invention provides a kind of containing in graphene oxide-copper silver nanoparticle compound Medicine antibacterial sanitary napkin, and a kind of Chinese medicine antibacterial anti-inflammatory liquid is provided, the liquid is to female such as pruritus of vagina, leukorrhea peculiar smell, vaginitis Sex chromosome mosaicism has improvement and therapeutic effect well.
The present invention provides a kind of Chinese medicine antibacterial sanitary napkin containing graphene oxide-copper silver nanoparticle compound, table in sanitary napkin Layer has sprayed antiseptic anti-inflammatory, and the liquid is prepared by the raw material including following parts by weight:Graphene oxide-copper silver is received 15-20 parts of compound of rice, 15-20 parts of radix scutellariae, 15-20 parts of Fructus Forsythiae, 15-20 parts of Chinese gall, 10-15 parts of Lasiosphaera fenzlii, cloves 10-15 Part, 10-15 parts of wrinkled giant hyssop, 10-15 parts of folium artemisiae argyi, 10-15 parts of motherwort, 5-7 parts of rose, 5-7 parts of China rose, 5-7 parts of red halloysite, 3-5 parts of the root of bidentate achyranthes, 3-5 parts of cockscomb, 3-5 parts of pyrrosia lingua, 1-2 parts of akebi, 1-2 parts of field thistle.
As further improvement of the invention, liquid is prepared by the raw material including following parts by weight:Graphene oxide- 18 parts of copper silver nanoparticle compound, 17 parts of radix scutellariae, 17 parts of Fructus Forsythiae, 15 parts of Chinese gall, 14 parts of Lasiosphaera fenzlii, 12 parts of cloves, 12 parts of wrinkled giant hyssop, Chinese mugwort 12 parts of leaf, 10 parts of motherwort, 7 parts of rose, 6 parts of China rose, 6 parts of red halloysite, 4 parts of the root of bidentate achyranthes, 4 parts of cockscomb, 3 parts of pyrrosia lingua, wood Lead to 2 parts, 1 part of field thistle.
As further improvement of the invention, liquid also contains freshener n-ethyl-p-menthane-3 alcohol and fragrance.
As further improvement of the invention, the preparation method of graphene oxide-copper silver nanoparticle compound, steps are as follows:
(1) prepared by graphene oxide:Graphene oxide is prepared using improved Hummers methods;
(2) preparation of graphene oxide-copper silver nanoparticle compound:The graphene oxide of step (1) preparation is weighed, addition is gone Ionized water is ultrasonically treated 30min, obtains uniform graphene oxide-aqueous dispersions, be protected from light be added isometric silver nitrate solution, Copper nitrate solution, glucose solution and ammonia spirit, are vigorously stirred reaction 2h, filtering, and deionized water is washed repeatedly to get oxidation Graphene-copper silver nanoparticle compound.
As further improvement of the invention, antiseptic anti-inflammatory solvent is ethyl alcohol, glycerine or its mixed solvent.
As further improvement of the invention, the preparation method of antiseptic anti-inflammatory includes the following steps:
(1) radix scutellariae, Fructus Forsythiae, Chinese gall, Lasiosphaera fenzlii, cloves, wrinkled giant hyssop, folium artemisiae argyi, motherwort, rose, China rose, red stone are taken Fat, the root of bidentate achyranthes, cockscomb, pyrrosia lingua, akebi, field thistle mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, decompression Filtering, filtrate are spare;
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare;
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0- 1.5, graphene oxide-copper silver nanoparticle compound is added, by 1:2 are dissolved in solvent, and ultrasonic disperse is uniformly to get antibiosis anti-inflammatory drug Liquid.
As further improvement of the invention, the fountain height of Chinese medicine antibacterial liquid is 5-10mL/m2.
As further improvement of the invention, surface material is cotton, non-woven fabrics or silk.
As further improvement of the invention, sanitary napkin can be prepared into common, ultra-thin, overlength, thicken style.
The invention also includes antiseptic anti-inflammatories prepared by the above method and composition.
The present invention has the advantages that:
1, graphene oxide-copper silver nanoparticle compound all has significant antibacterial, antibacterial volume to a variety of germs in the present invention Effect increases the activity of liquid, and safe without toxic side effect, can be used for medical sanitary articles for use;
2, antibacterial of the present invention, antibacterial liquid select pure Chinese medicine extract, are free of chemosynthesis medicine, and Pure natural nontoxic is done harm to, And it is with obvious effects, it has no toxic side effect;
3, source of the present invention it is simple, it is of low cost, work well, have good application prospect.
Description of the drawings
Fig. 1 is the preparation technology figure of graphene oxide-copper silver nanoparticle compound.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical solution in the embodiment of the present invention carries out clear, complete description, Obviously, the embodiment described is the embodiment of the part of representative of the present invention, rather than whole embodiments, this field are general Other all embodiments that logical technical staff is obtained without making creative work belong to the protection of the present invention Range.
1 graphene oxide of embodiment-copper silver nanoparticle compound
(1) prepared by graphene oxide:Graphene oxide is prepared using improved Hummers methods;
(2) preparation of graphene oxide-copper silver nanoparticle compound:The graphene oxide of step (1) preparation is weighed, addition is gone Ionized water is ultrasonically treated 30min, obtains uniform graphene oxide-aqueous dispersions, be protected from light be added isometric silver nitrate solution, Copper nitrate solution, glucose solution and ammonia spirit, are vigorously stirred reaction 2h, filtering, and deionized water is washed repeatedly to get oxidation Graphene-copper silver nanoparticle compound.
The preparation of 2 Chinese medicine antibacterial anti-inflammatory liquid of embodiment
Raw material forms:Graphene oxide -20 parts of copper silver nanoparticle compound, 20 parts of radix scutellariae, 20 parts of Fructus Forsythiae, 20 parts of Chinese gall, 15 parts of Lasiosphaera fenzlii, 15 parts of cloves, 15 parts of wrinkled giant hyssop, 15 parts of folium artemisiae argyi, 15 parts of motherwort, 7 parts of rose, 7 parts of China rose, 7 parts of red halloysite, 5 parts of the root of bidentate achyranthes, 5 parts of cockscomb, 5 parts of pyrrosia lingua, 2 parts of akebi, 2 parts of field thistle.
Preparation process:
(1) radix scutellariae, Fructus Forsythiae, Chinese gall, Lasiosphaera fenzlii, cloves, wrinkled giant hyssop, folium artemisiae argyi, motherwort, rose, China rose, red stone are taken Fat, the root of bidentate achyranthes, cockscomb, pyrrosia lingua, akebi, field thistle mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, decompression Filtering, filtrate are spare;
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare;
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0- 1.5, graphene oxide-copper silver nanoparticle compound is added, by 1:2 are dissolved in glycerine, and ultrasonic disperse is uniformly to get antibiosis anti-inflammatory drug Liquid.
The preparation of 3 Chinese medicine antibacterial anti-inflammatory liquid of embodiment
Raw material forms:Graphene oxide -18 parts of copper silver nanoparticle compound, 17 parts of radix scutellariae, 17 parts of Fructus Forsythiae, 15 parts of Chinese gall, 14 parts of Lasiosphaera fenzlii, 12 parts of cloves, 12 parts of wrinkled giant hyssop, 12 parts of folium artemisiae argyi, 10 parts of motherwort, 7 parts of rose, 6 parts of China rose, 6 parts of red halloysite, 4 parts of the root of bidentate achyranthes, 4 parts of cockscomb, 3 parts of pyrrosia lingua, 2 parts of akebi, 1 part of field thistle.
Preparation process:
(1) radix scutellariae, Fructus Forsythiae, Chinese gall, Lasiosphaera fenzlii, cloves, wrinkled giant hyssop, folium artemisiae argyi, motherwort, rose, China rose, red stone are taken Fat, the root of bidentate achyranthes, cockscomb, pyrrosia lingua, akebi, field thistle mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, decompression Filtering, filtrate are spare;
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare;
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0- 1.5, graphene oxide-copper silver nanoparticle compound is added, by 1:2 are dissolved in ethyl alcohol, and ultrasonic disperse is uniformly to get antibiosis anti-inflammatory drug Liquid.
The preparation of 4 Chinese medicine antibacterial anti-inflammatory liquid of embodiment
Raw material forms:Graphene oxide -15 parts of copper silver nanoparticle compound, 15 parts of radix scutellariae, 15 parts of Fructus Forsythiae, 15 parts of Chinese gall, 10 parts of Lasiosphaera fenzlii, 10 parts of cloves, 1 part of wrinkled giant hyssop, 10 parts of folium artemisiae argyi, 10 parts of motherwort, 5 parts of rose, 5 parts of China rose, 5 parts of red halloysite, 3 parts of the root of bidentate achyranthes, 3 parts of cockscomb, 3 parts of pyrrosia lingua, 1 part of akebi, 1 part of field thistle.
Preparation process:
(1) radix scutellariae, Fructus Forsythiae, Chinese gall, Lasiosphaera fenzlii, cloves, wrinkled giant hyssop, folium artemisiae argyi, motherwort, rose, China rose, red stone are taken Fat, the root of bidentate achyranthes, cockscomb, pyrrosia lingua, akebi, field thistle mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, decompression Filtering, filtrate are spare;
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare;
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0- 1.5, graphene oxide-copper silver nanoparticle compound is added, by 1:2 are dissolved in glycerin-ethanol mixed solution, and ultrasonic disperse is uniform, Up to antiseptic anti-inflammatory.
The preparation of Chinese medicine antibacterial sanitary napkin of the embodiment 5 containing graphene oxide-copper silver nanoparticle compound
A kind of Chinese medicine antibacterial sanitary napkin containing graphene oxide-copper silver nanoparticle compound, including (material is pure cotton for endosexine Spun laced fabric), Chinese medicine antibacterial liquid prepared by embodiment 3, fountain height 7mL/m are sprayed in surface2, and be arranged under the endosexine The anti-of side bleeds back layer, and is arranged in the anti-superpower imbibition layer bled back below layer, and is arranged below the superpower imbibition layer Macromolecule water lock layer, and the distributed ventilated membrane below the macromolecule water lock layer is set, that is, is prepared into containing graphite oxide The Chinese medicine antibacterial sanitary napkin of alkene-copper silver nanoparticle compound.This is common style.
The different sanitary napkin bacteriostasis contrast tests of test example 1
Reference《National Standard of the People's Republic of China GB15979-1995, Disposable Sanitary Accessory sanitary standard》, Sanitary napkin made from embodiment 2-6 and comparative example 1-2 is detected to the bacteriostasis property of following three kinds of microorganisms.The micro- life tested Object:Escherichia coli;Staphylococcus aureus;Candida albicans.
Embodiment 5, a thousand pieces of gold only four sections of refined sanitary napkin, noble and unsullied silk draft bacteria-inhibiting type sanitary napkin and Shu Ting sanitary napkins through ultraviolet irradiation After 1.5min sterilizations, the even spread Escherichia coli 1.0 × 10 on sanitary napkin surface layer5CFU/ pieces, staphylococcus aureus 1.0 × 105CFU/ pieces, Candida albicans 1.0 × 105CFU/ pieces, effect are tested after 30 minutes, and concrete outcome is shown in Table 1:
1 sanitary napkin bacteriostasis property result table (unit of table:CFU/ pieces)
By the above experimental result it is found that different sanitary napkin antibacterial effects are different, sanitary napkin prepared by embodiment 5 can be apparent Inhibit Escherichia coli, staphylococcus aureus and Candida albicans, effect is superior to other three sections antibacterial sanitary napkins on the market.
2 women clinical trial of test example
1, group is tested.It is divided into experimental group and control group.
2, experimental method.
(1) case selection.Select 2 months in December, 2017 in 2017 climacteric of gynemetrics of this city central hospital diagnosis and treatment Vaginitis 100.Inclusion criteria:The menopause time at 1 year or more, meets vagina inflammation diagnostic criteria.The age of 100 patients in group It it is 43~54 years old, 47.61 years old average, the course of disease -3 years 4 months is 1.78 years average.It is divided into control group and reality according to table of random numbers method Test group, every group 100.The average age of control group patient is 47.69 years old, average course of disease 1.76;Experimental group patient's is averaged Age is 47.58 years old, average course of disease 1.80.
Exclusion criteria:Acute infectious diseases;The diseases such as autoimmune;Merge the nonspecific vaginitis such as trichomonad, mould; The used estrogen of the preceding 1 month planted agent for the treatment of and antibiotic person;Patient lost to follow-up and unfinished treatment patient.
(2) experimental method.Control group gives the scorching clean cleaning treatment of woman, Chinese medicine antibacterial prepared by experimental group Application Example 3 Treatment, two groups of treatments every night 1 time, continuous application 14d are wiped outside liquid, medication 1 time the next day being changed to later treats 14d, is within 4 weeks One course for the treatment of.
(3) observation index and evaluation method
Vaginitis symptom score treat it is forward and backward score respectively the symptom of patient's vaginitis, standards of grading:1. scabies Itch, cusalgia, intercourse pain (without, slight, medium, severe be respectively 0, l, 2,3 points);2. secretion (nothing;It is dilute, slightly more;It is yellowish, more; Purulence, be respectively 0, l, 2,3 points).3. comprehensive score cures (O-2 points), improve (3-7 points), invalid (≤8 point).
Experimental result such as table 2 and table 3
2 two groups of patient clinical curative effects of table compare (%)
The pretherapy and post-treatment vaginitis symptom score of 3 two groups of patients of table compares
By the above experimental result it is found that the Chinese medicine antibacterial anti-inflammatory liquid of the present invention has apparent treatment effect to women vaginitis Fruit, to effects of being significantly improved such as clinical symptoms itch, cusalgia, intercourse pain, secretion, protects since gynaecologic washing lotion woman's inflammation is clean Protect women's health.
Those skilled in the art is not under conditions of departing from the spirit and scope of the present invention of claims determination, also Various modifications can be carried out to the above content.Therefore the scope of the present invention is not limited in above explanation, but by The range of claims determines.

Claims (10)

1. a kind of Chinese medicine antibacterial sanitary napkin containing graphene oxide-copper silver nanoparticle compound, which is characterized in that in the sanitary napkin Antiseptic anti-inflammatory has been sprayed on surface layer, and the liquid is prepared by the raw material including following parts by weight:Graphene oxide-copper silver 15-20 parts of nano-complex, 15-20 parts of radix scutellariae, 15-20 parts of Fructus Forsythiae, 15-20 parts of Chinese gall, 10-15 parts of Lasiosphaera fenzlii, cloves 10-15 Part, 10-15 parts of wrinkled giant hyssop, 10-15 parts of folium artemisiae argyi, 10-15 parts of motherwort, 5-7 parts of rose, 5-7 parts of China rose, 5-7 parts of red halloysite, 3-5 parts of the root of bidentate achyranthes, 3-5 parts of cockscomb, 3-5 parts of pyrrosia lingua, 1-2 parts of akebi, 1-2 parts of field thistle.
2. the Chinese medicine antibacterial sanitary napkin according to claim 1 containing graphene oxide-copper silver nanoparticle compound, feature exist In the liquid is prepared by the raw material including following parts by weight:Graphene oxide -18 parts of copper silver nanoparticle compound, radix scutellariae 17 parts, 17 parts of Fructus Forsythiae, 15 parts of Chinese gall, 14 parts of Lasiosphaera fenzlii, 12 parts of cloves, 12 parts of wrinkled giant hyssop, 12 parts of folium artemisiae argyi, 10 parts of motherwort, rose Spend 7 parts, 6 parts of China rose, 6 parts of red halloysite, 4 parts of the root of bidentate achyranthes, 4 parts of cockscomb, 3 parts of pyrrosia lingua, 2 parts of akebi, 1 part of field thistle.
3. the Chinese medicine antibacterial sanitary napkin according to claim 1 containing graphene oxide-copper silver nanoparticle compound, feature exist In the liquid also contains freshener n-ethyl-p-menthane-3 alcohol and fragrance.
4. the Chinese medicine antibacterial sanitary napkin according to claim 1 or claim 2 containing graphene oxide-copper silver nanoparticle compound, feature It is, the preparation method of the graphene oxide-copper silver nanoparticle compound, steps are as follows:
(1) prepared by graphene oxide:Graphene oxide is prepared using improved Hummers methods;
(2) preparation of graphene oxide-copper silver nanoparticle compound:The graphene oxide of step (1) preparation is weighed, deionization is added Water is ultrasonically treated 30min, obtains uniform graphene oxide-aqueous dispersions, is protected from light and isometric silver nitrate solution, nitric acid is added Copper solution, glucose solution and ammonia spirit, are vigorously stirred reaction 2h, filtering, and deionized water is washed repeatedly to get graphite oxide Alkene-copper silver nanoparticle compound.
5. the Chinese medicine antibacterial sanitary napkin according to claim 1 or claim 2 containing graphene oxide-copper silver nanoparticle compound, feature It is, the antiseptic anti-inflammatory solvent can be ethyl alcohol, glycerine or its mixed solvent.
6. the Chinese medicine antibacterial mask according to claim 1 containing graphene oxide-copper silver nanoparticle compound, which is characterized in that The preparation method of the antiseptic anti-inflammatory includes the following steps:
(1) radix scutellariae, Fructus Forsythiae, Chinese gall, Lasiosphaera fenzlii, cloves, wrinkled giant hyssop, folium artemisiae argyi, motherwort, rose, China rose, red halloysite, ox are taken Knee, cockscomb, pyrrosia lingua, akebi, field thistle mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, are filtered under diminished pressure, Filtrate is spare;
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare;
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate adds to relative density 1.0-1.5 Enter graphene oxide-copper silver nanoparticle compound, by 1:2 are dissolved in solvent, and ultrasonic disperse is uniformly to get antiseptic anti-inflammatory.
7. a kind of antiseptic anti-inflammatory prepared according to composition described in claim 1-5 any claims.
8. being defended according to the Chinese medicine antibacterial containing graphene oxide-copper silver nanoparticle compound described in claim 1-6 any claims Raw towel, which is characterized in that fountain height 5-10mL/m2
9. the Chinese medicine antibacterial sanitary napkin according to claim 8 containing graphene oxide-copper silver nanoparticle compound, feature exist In the surface material is cotton, non-woven fabrics or silk.
10. the Chinese medicine antibacterial sanitary napkin according to claim 9 containing graphene oxide-copper silver nanoparticle compound, feature exist In the sanitary napkin can be prepared into common, ultra-thin, overlength, thicken style.
CN201810211434.4A 2018-03-15 2018-03-15 Chinese medicine antibacterial sanitary napkin containing graphene oxide-copper silver nanoparticle compound Pending CN108273118A (en)

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CN113577367A (en) * 2021-08-13 2021-11-02 东莞市金保利卫生用品有限公司 Sanitary towel for recuperating and detoxifying and preparation method thereof
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Application publication date: 20180713