CN110664870A - Traditional Chinese medicine powder for treating kidney stone and preparation method thereof - Google Patents

Traditional Chinese medicine powder for treating kidney stone and preparation method thereof Download PDF

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CN110664870A
CN110664870A CN201911152432.3A CN201911152432A CN110664870A CN 110664870 A CN110664870 A CN 110664870A CN 201911152432 A CN201911152432 A CN 201911152432A CN 110664870 A CN110664870 A CN 110664870A
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周桂芳
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    • A61K36/68Plantaginaceae (Plantain Family)
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/04Drugs for disorders of the urinary system for urolithiasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to traditional Chinese medicine powder for treating kidney stones and a preparation method thereof. The Chinese medicine powder is prepared through processing, powdering, mixing and packing, and has fast acting, no toxic side effect, simple preparation process, convenient taking and low cost. The medicine and the root cause are treated simultaneously, large stones are dissolved, become small and are discharged out of the body, and the recurrence and the appearance of the stones are effectively prevented.

Description

Traditional Chinese medicine powder for treating kidney stone and preparation method thereof
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to traditional Chinese medicine powder for treating kidney stones and a preparation method thereof.
Background
Kidney stone crystallization can cause kidney deficiency to cause long-term waist and leg diseases, kidney necrosis can be caused by kidney stone crystallization to cause kidney extirpation, kidney chronic inflammation is caused by improper treatment of kidney stone crystallization until kidney failure (uremia) is formed, and then labor force, disability and even life are lost.
The traditional Chinese medicine considers that: kidney is mainly used for water, kidney stone crystallization can cause kidney deficiency, so that repeated attacks of chronic nephritis and chronic pyelonephritis are caused, a series of complications such as abnormal water distribution, dysuria, body fluid retention, general edema, urinary incontinence, excessive drinking and urination, frequent nocturia and the like are formed, and after kidney stone crystallization is cured, proper kidney tonifying, yang strengthening and bone strengthening are carried out, so that the disease can obtain good curative effect; kidneys govern bone marrow, and kidney essence is sufficient, so that bone marrow and brain are abundant and strong, limbs are light and powerful, the movement is sensitive, the energy is abundant, and the ears and eyes are smart and clear. The kidney essence deficiency can be caused by the kidney stone crystallization, and symptoms such as bone deficiency weakness, anemia, dizziness, amnesia and the like appear, if the kidney stone crystallization is dissolved away, the diseases can be improved or cured after the method for treating by nourishing yin, tonifying kidney, strengthening yang, tonifying kidney, regulating and replenishing qi and blood and adjusting the body resistance is adopted; the kidney governs qi reception, the respiration is coordinated with the lung, the kidney is needed to assist the lung to inhale and descend qi, the kidney is found to have calculi crystallization or kidney swelling in the kidney in the examination process such as chronic tracheitis, chronic bronchial asthma, long-term cold difficult healing and resistance reduction caused by lung and kidney weakness, and if the kidney calculi crystallization or the kidney swelling is cured after being dissolved, the kidney and the lung are properly adjusted and supplemented, so that the diseases are all improved or cured.
Therefore, dissolution of intrarenal calculus crystals is very important in the course of disease treatment. If the calculus in the kidney is crystallized and dissolved and the residue is removed, then the kidney deficiency is improved, the kidney function is strengthened, and the kidney yin, kidney yang and qi and blood are regulated and supplemented, so that the disease can be easily solved. And if the calculus crystallization residues in the kidney are not removed, the effect is not good only through the treatment of tonifying the kidney. At present, the treatment of the kidney stone depends on minimally invasive surgery and ultrasonic lithotripsy. The stone is taken in the minimally invasive surgery, causes are not removed, small stones cannot be taken completely, the recurrence rate is high, the work is influenced, the cost is high, and common people cannot bear the stone. The ultrasonic lithotripsy has a small application range, is only suitable for stones with specific size ranges, small stones are difficult to locate, the remaining small stones can continue to grow, and the recurrence rate is extremely high. In addition, in clinic, the calculus crystallization residues in the kidney of many patients are small, and some doctors consider that the calculus or residues can be automatically removed, so that early treatment of the disease is ignored, and the calculus is enlarged and the kidney function is damaged. According to clinical experience, the patient with renal deficiency and asthenia can not remove calculus easily, so the medicine can remove residue in kidney in time, and has good prevention effect on preventing and treating calculus crystallization increase and chronic inflammation of kidney stimulation.
Disclosure of Invention
Based on the above, the invention provides a traditional Chinese medicine powder for treating kidney stone, and the purpose of the invention is realized by the following technical scheme:
the invention firstly provides a traditional Chinese medicine powder for treating kidney stone, which comprises the following components: cortex Cinnamomi, spora Lygodii, caulis Akebiae, and radix Curcumae
Herba Desmodii Styracifolii, pulvis Talci, Glycyrrhrizae radix, and semen plantaginis.
Preferably, the pharmaceutical components and the dosage comprise 5 ~ 10 parts of cinnamon, 10 ~ 15 parts of climbing fern spore, 15 ~ 20 parts of akebia stem, 20 ~ 25 parts of desmodium, 15 ~ 20 parts of talcum powder, 3 ~ 6 parts of liquorice and 15 ~ 20 parts of plantain seed by weight.
Preferably, the medicine components and the dosage comprise 6 ~ 9 parts of cinnamon, 11 ~ 14 parts of climbing fern spore, 16 ~ 19 parts of akebia stem, 21 ~ 24 parts of desmodium, 16 ~ 19 parts of talcum powder, 3 ~ 5 parts of liquorice and 16 ~ 19 parts of plantain seed by weight.
The efficacies of the medicines are as follows:
cinnamon: pungent, sweet and warm in flavor. It enters kidney, spleen, heart and liver meridians. This herb is pungent, sweet and hot, and pure yang warming and dispersing. Entering kidney meridian, it is the essential herb for treating deficiency-cold of lower energizer and floating of deficient yang because it can warm and nourish fire of Mingmen to tonify yang and eliminate yin, and induce fire to return to original origin. Entering spleen meridian, it is good at warming spleen yang and dispelling cold, so it is a good herb for yang deficiency and middle cold. It enters heart and liver meridians and excels in dispersing blood and yin cold to warm meridians and unblock collaterals, so it is commonly used for congealing cold and blood stasis. Has the effects of supplementing fire and supporting yang, guiding fire to the original, dispelling cold and relieving pain, and warming channels and promoting blood circulation.
Climbing fern spore: sweet and bland in flavor and cold in nature. It enters bladder and small intestine meridians. It is sweet, bland and sweet in flavor, and cold in property of clearing and purging, entering bladder and small intestine meridians. It is good at inducing diuresis to alleviate pain and removing urinary calculus, so it is commonly used for stranguria syndrome with astringency and edema, and is especially good at treating stranguria with astringency and pain in urethra. Has effects in promoting urination, treating stranguria, and relieving pain.
B, wood through: bitter taste and cold nature. It enters heart, small intestine and bladder meridians. It is bitter and cold with the actions of purging and descending, and unblocking and draining, so it enters heart and small intestine meridians, and enters bladder meridian. Clear heart fire, promote urination, conduct heat downward. It is good at inducing diuresis to treat stranguria and clearing heat, and can dredge meridians and promote lactation. It is not only the essential herb for stranguria and edema due to damp-heat, but also the good herb for ascending heart fire and descending small intestine, and also the good herb for treating galactostasis and arthralgia due to damp-heat. Has the effects of inducing diuresis for treating stranguria, clearing heat, dredging channels and promoting lactation.
Herba Lysimachiae Christinae: sweet and bland in flavor, slightly cold in nature. It enters liver. Gallbladder, kidney, and bladder meridians. It is sweet, bland, oozing and sweet, slightly cold and clear. Entering kidney and bladder meridians, it is good at inducing diuresis to treat stranguria and removing calculus, and is the essential herb for treating stranguria due to stone; it enters liver and gallbladder meridians and is good at removing dampness and jaundice, so it is a good herb for jaundice due to damp-heat and liver and gallbladder calculus. It can also clear heat and remove toxicity to relieve swelling, so it is commonly used for treating sores and swelling, snake injuries. Has effects of inducing diuresis for treating stranguria, removing dampness, eliminating jaundice, and relieving swelling and removing toxic substance.
Talc powder: sweet and bland in flavor and cold in nature. It enters stomach and bladder meridians. It is a good herb for damp-heat stranguria pain, and clearing summer-heat, because it can clear heat, purge and smooth, clear damp-heat in bladder, induce diuresis and treat stranguria, and is a good herb for treating summer-heat dampness and damp-warm disease. For external use, it can clear heat, astringe dampness and heal wound, and is commonly used for eczema. Has the effects of inducing diuresis for treating stranguria, clearing away summer-heat, and clearing away heat and healing sore for external use.
Licorice root: sweet in flavor and neutral in nature. It enters spleen, stomach, lung and heart meridians. It can tonify middle energizer and qi, relieve spasm and pain, alleviate drug properties, dispel phlegm and relieve cough, and remove toxicity. Unprocessed with mild and cool property can purge fire and remove toxicity. Has the effects of invigorating spleen and replenishing qi, eliminating phlegm and relieving cough, removing toxic substances, relieving spasm and pain, and relieving drug property.
Plantain seed: sweet in flavor and cold in nature. It enters kidney, liver and lung meridians. It is sweet and cold with the actions of smoothing and clearing heat, and can induce diuresis and clear heat to treat stranguria, and treat damp-heat in lower energizer and edema with heat; but also induce diuresis, separate clear from turbid and check diarrhea, and treat summer-heat damp diarrhea; also clear liver and improve vision, clear lung and resolve phlegm, treat liver heat and conjunctival congestion and phlegm heat cough. Has effects of promoting diuresis for treating stranguria, eliminating dampness, relieving diarrhea, improving eyesight, clearing lung-heat, and eliminating phlegm.
The invention also provides a preparation method of the traditional Chinese medicine powder for treating kidney stone, which comprises the following steps:
(1) processing the talcum powder: grinding clean pulvis Talci into fine powder, or coarse powder of pulvis Talci, adding small amount of water, grinding to fine powder, adding appropriate amount of clear water, stirring, pouring the upper suspension, settling, repeating the above method for several times, mixing the suspensions, standing for precipitation, pouring out the supernatant, sun drying the precipitate, and grinding into fine powder to obtain processed pulvis Talci;
(2) processing the other medicinal materials: removing impurities from cortex Cinnamomi, scraping off coarse bark, and mashing into small pieces; taking raw medicinal materials from lygodium japonicum, and winnowing impurities; removing impurities from caulis Akebiae, soaking in water, taking out, slicing, and drying; cleaning herba Lysimachiae Christinae, cutting into segments, and sun drying; collecting Glycyrrhrizae radix, removing impurities, cleaning, moistening, peeling or scraping, slicing, drying, and sieving to remove debris. The skin-carrying person is liquorice tablets, and the skin-free person is liquorice tablets; taking the raw medicinal materials of the plantain seeds, removing impurities, and screening out dust;
(3) pulverizing the five traditional Chinese medicines except the spora lygodii and the talcum powder into powder, uniformly mixing the powder according to the weight parts of the medicinal components and the dosage, grinding the powder in a colloid mill again to obtain fine traditional Chinese medicine powder, sieving the fine traditional Chinese medicine powder with a 400 ~ 500-mesh sieve, sterilizing at high temperature, and packaging into bags.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine powder for treating kidney stone provided by the invention has the advantages of unique formula, mild medicine property, quick response, no toxic or side effect, simple preparation method, convenience in taking and low cost. After the medicine is used, the internal environment of a human body is improved, the medicine directly acts on the affected part, the principal and secondary aspects are treated simultaneously, larger calculus is dissolved, the calculus becomes smaller and is discharged out of the body, the recurrence and appearance of the calculus are effectively prevented, and the effective rate is 95.6%.
Detailed Description
The invention provides a traditional Chinese medicine powder for treating kidney stone, which comprises the following components: cinnamon, lygodium japonicum, akebia stem, desmodium, talcum powder, liquorice and plantain seed.
Preferably, the pharmaceutical components and the dosage comprise 5 ~ 10 parts of cinnamon, 10 ~ 15 parts of climbing fern spore, 15 ~ 20 parts of akebia stem, 20 ~ 25 parts of desmodium, 15 ~ 20 parts of talcum powder, 3 ~ 6 parts of liquorice and 15 ~ 20 parts of plantain seed by weight.
Preferably, the medicine components and the dosage comprise 6 ~ 9 parts of cinnamon, 11 ~ 14 parts of climbing fern spore, 16 ~ 19 parts of akebia stem, 21 ~ 24 parts of desmodium, 16 ~ 19 parts of talcum powder, 3 ~ 5 parts of liquorice and 16 ~ 19 parts of plantain seed by weight.
The invention also provides a preparation method of the traditional Chinese medicine powder for treating kidney stone, which comprises the following steps:
(1) processing the talcum powder: grinding clean pulvis Talci into fine powder, or coarse powder of pulvis Talci, adding small amount of water, grinding to fine powder, adding appropriate amount of clear water, stirring, pouring the upper suspension, settling, repeating the above method for several times, mixing the suspensions, standing for precipitation, pouring out the supernatant, sun drying the precipitate, and grinding into fine powder to obtain processed pulvis Talci;
(2) processing the other medicinal materials: removing impurities from cortex Cinnamomi, scraping off coarse bark, and mashing into small pieces; taking raw medicinal materials from lygodium japonicum, and winnowing impurities; removing impurities from caulis Akebiae, soaking in water, taking out, slicing, and drying; cleaning herba Lysimachiae Christinae, cutting into segments, and sun drying; collecting Glycyrrhrizae radix, removing impurities, cleaning, moistening, peeling or scraping, slicing, drying, and sieving to remove debris. The skin-carrying person is liquorice tablets, and the skin-free person is liquorice tablets; taking the raw medicinal materials of the plantain seeds, removing impurities, and screening out dust;
(3) pulverizing the five traditional Chinese medicines except the spora lygodii and the talcum powder into powder, uniformly mixing the powder according to the weight parts of the medicinal components and the dosage, grinding the powder in a colloid mill again to obtain fine traditional Chinese medicine powder, sieving the fine traditional Chinese medicine powder with a 400 ~ 500-mesh sieve, sterilizing at high temperature, packaging into bags, and taking the medicine orally when in use.
The technical solution of the present invention will be further described in detail with reference to specific embodiments. The following examples are merely illustrative and explanatory of the present invention and should not be construed as limiting the scope of the invention. All the technologies realized based on the above-mentioned contents of the present invention are covered in the protection scope of the present invention.
Unless otherwise indicated, the raw materials and reagents used in the following examples are all commercially available products or can be prepared by known methods.
Example 1
The invention provides a traditional Chinese medicine powder for treating kidney stone, which comprises 5 parts of cinnamon,
10 parts of lygodium japonicum, 15 parts of akebia stem, 20 parts of desmodium, 15 parts of talcum powder, 3 parts of liquorice and 15 parts of plantain seed.
The invention also provides a preparation method of the traditional Chinese medicine powder for treating kidney stone, which comprises the following steps:
(1) processing the talcum powder: grinding clean pulvis Talci into fine powder, or coarse powder of pulvis Talci, adding small amount of water, grinding to fine powder, adding appropriate amount of clear water, stirring, pouring the upper suspension, settling, repeating the above method for several times, mixing the suspensions, standing for precipitation, pouring out the supernatant, sun drying the precipitate, and grinding into fine powder to obtain processed pulvis Talci;
(2) processing the other medicinal materials: removing impurities from cortex Cinnamomi, scraping off coarse bark, and mashing into small pieces; taking raw medicinal materials from lygodium japonicum, and winnowing impurities; removing impurities from caulis Akebiae, soaking in water, taking out, slicing, and drying; cleaning herba Lysimachiae Christinae, cutting into segments, and sun drying; collecting Glycyrrhrizae radix, removing impurities, cleaning, moistening, peeling or scraping, slicing, drying, and sieving to remove debris. The skin-carrying person is liquorice tablets, and the skin-free person is liquorice tablets; taking the raw medicinal materials of the plantain seeds, removing impurities, and screening out dust;
(3) pulverizing the five traditional Chinese medicines except the spora lygodii and the talcum powder into powder, uniformly mixing the powder according to the weight parts of the medicinal components and the dosage, grinding the powder in a colloid mill again to obtain fine traditional Chinese medicine powder, sieving the fine traditional Chinese medicine powder with a 400-mesh sieve, sterilizing at high temperature, and packaging into bags.
Example 2
The invention provides a traditional Chinese medicine powder for treating kidney stone, which comprises 10 weight parts of cinnamon
15 parts of climbing fern spore, 20 parts of akebia stem, 25 parts of desmodium, 20 parts of talcum powder, 6 parts of liquorice and 20 parts of plantain seed.
The invention also provides a preparation method of the traditional Chinese medicine powder for treating kidney stone, which comprises the following steps:
(1) processing the talcum powder: grinding clean pulvis Talci into fine powder, or coarse powder of pulvis Talci, adding small amount of water, grinding to fine powder, adding appropriate amount of clear water, stirring, pouring the upper suspension, settling, repeating the above method for several times, mixing the suspensions, standing for precipitation, pouring out the supernatant, sun drying the precipitate, and grinding into fine powder to obtain processed pulvis Talci;
(2) processing the other medicinal materials: removing impurities from cortex Cinnamomi, scraping off coarse bark, and mashing into small pieces; taking raw medicinal materials from lygodium japonicum, and winnowing impurities; removing impurities from caulis Akebiae, soaking in water, taking out, slicing, and drying; cleaning herba Lysimachiae Christinae, cutting into segments, and sun drying; collecting Glycyrrhrizae radix, removing impurities, cleaning, moistening, peeling or scraping, slicing, drying, and sieving to remove debris. The skin-carrying person is liquorice tablets, and the skin-free person is liquorice tablets; taking the raw medicinal materials of the plantain seeds, removing impurities, and screening out dust;
(3) pulverizing the five traditional Chinese medicines except the spora lygodii and the talcum powder into powder, uniformly mixing the powder according to the weight parts of the medicinal components and the dosage, grinding the powder in a colloid mill again to obtain fine traditional Chinese medicine powder, sieving the fine traditional Chinese medicine powder with a 500-mesh sieve, sterilizing at high temperature, and packaging into bags.
Example 3
The invention provides a traditional Chinese medicine powder for treating kidney stone, which comprises the following medicinal components and dosage of cinnamon 12 in parts by weight
12 parts of lygodium japonicum, 18 parts of akebia stem, 22 parts of desmodium, 16 parts of talcum powder, 4 parts of liquorice and 16 parts of plantain seed.
The invention also provides a preparation method of the traditional Chinese medicine powder for treating kidney stone, which comprises the following steps:
(1) processing the talcum powder: grinding clean pulvis Talci into fine powder, or coarse powder of pulvis Talci, adding small amount of water, grinding to fine powder, adding appropriate amount of clear water, stirring, pouring the upper suspension, settling, repeating the above method for several times, mixing the suspensions, standing for precipitation, pouring out the supernatant, sun drying the precipitate, and grinding into fine powder to obtain processed pulvis Talci;
(2) processing the other medicinal materials: removing impurities from cortex Cinnamomi, scraping off coarse bark, and mashing into small pieces; taking raw medicinal materials from lygodium japonicum, and winnowing impurities; removing impurities from caulis Akebiae, soaking in water, taking out, slicing, and drying; cleaning herba Lysimachiae Christinae, cutting into segments, and sun drying; collecting Glycyrrhrizae radix, removing impurities, cleaning, moistening, peeling or scraping, slicing, drying, and sieving to remove debris. The skin-carrying person is liquorice tablets, and the skin-free person is liquorice tablets; taking the raw medicinal materials of the plantain seeds, removing impurities, and screening out dust;
(3) pulverizing the five traditional Chinese medicines except the spora lygodii and the talcum powder into powder, uniformly mixing the powder according to the weight parts of the medicinal components and the dosage, grinding the powder in a colloid mill again to obtain fine traditional Chinese medicine powder, sieving the fine traditional Chinese medicine powder with a 450-mesh sieve, sterilizing at high temperature, and packaging into bags.
The foregoing is only a preferred embodiment of the present invention. However, the present invention is not limited to the above embodiment. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. The traditional Chinese medicine powder for treating kidney stones is characterized by comprising the following components: cinnamon, lygodium japonicum, akebia stem, desmodium, talcum powder, liquorice and plantain seed.
2. The traditional Chinese medicine powder for treating kidney stones according to claim 1, wherein the medicine components and the dosage comprise, by weight, 5 ~ 10 parts of cinnamon, 10 ~ 15 parts of spora lygodii, 15 ~ 20 parts of akebia stem, 20 ~ 25 parts of desmodium, 15 ~ 20 parts of talcum powder, 3 ~ 6 parts of liquorice and 15 ~ 20 parts of plantain seed.
3. The traditional Chinese medicine powder for treating kidney stones according to claim 1, wherein the medicine components and dosage comprise, by weight, 6 ~ 9 parts of cinnamon, 11 ~ 14 parts of spora lygodii, 16 ~ 19 parts of akebia stem, 21 ~ 24 parts of lysimachia christinae hance, 16 ~ 19 parts of talcum powder, 3 ~ 5 parts of licorice and 16 ~ 19 parts of plantain seed.
4. A method for preparing a Chinese medicinal powder for the treatment of kidney stones according to any one of claims 1 to 3, wherein the preparation method comprises the steps of:
(1) processing the talcum powder: grinding clean pulvis Talci into fine powder, or coarse powder of pulvis Talci, adding small amount of water, grinding to fine powder, adding appropriate amount of clear water, stirring, pouring the upper suspension, settling, repeating the above method for several times, mixing the suspensions, standing for precipitation, pouring out the supernatant, sun drying the precipitate, and grinding into fine powder to obtain processed pulvis Talci;
(2) processing the other medicinal materials: removing impurities from cortex Cinnamomi, scraping off coarse bark, and mashing into small pieces; taking raw medicinal materials from lygodium japonicum, and winnowing impurities; removing impurities from caulis Akebiae, soaking in water, taking out, slicing, and drying; cleaning herba Lysimachiae Christinae, cutting into segments, and sun drying; collecting Glycyrrhrizae radix, removing impurities, cleaning, moistening, peeling or scraping, slicing, drying, and sieving to remove debris.
5. The skin-carrying person is liquorice tablets, and the skin-free person is liquorice tablets; taking the raw medicinal materials of the plantain seeds, removing impurities, and screening out dust;
(3) pulverizing the five traditional Chinese medicines except the spora lygodii and the talcum powder into powder, uniformly mixing the powder according to the weight parts of the medicinal components and the dosage, grinding the powder in a colloid mill again to obtain fine traditional Chinese medicine powder, sieving the fine traditional Chinese medicine powder with a 400 ~ 500-mesh sieve, sterilizing at high temperature, and packaging into bags.
CN201911152432.3A 2019-11-22 2019-11-22 Traditional Chinese medicine powder for treating kidney stone and preparation method thereof Pending CN110664870A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102908386A (en) * 2011-08-04 2013-02-06 孙斌 Traditional Chinese medicine for treating kidney stone
CN103110765A (en) * 2013-02-18 2013-05-22 于浩 Traditional Chinese medicine for treating renal calculi
CN107823358A (en) * 2017-11-29 2018-03-23 罗田县人民医院 A kind of pharmaceutical composition for treating kidney stone and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN102908386A (en) * 2011-08-04 2013-02-06 孙斌 Traditional Chinese medicine for treating kidney stone
CN103110765A (en) * 2013-02-18 2013-05-22 于浩 Traditional Chinese medicine for treating renal calculi
CN107823358A (en) * 2017-11-29 2018-03-23 罗田县人民医院 A kind of pharmaceutical composition for treating kidney stone and preparation method thereof

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Application publication date: 20200110