CN110664733A - Hyaluronic acid nanoemulsion gel for nursing female vagina - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention provides a hyaluronic acid nanoemulsion gel for nursing female vagina, which comprises the following main components in percentage by weight: glycerol: 6 percent; lactic acid: 0.5 percent; sodium hyaluronate: 0.5 percent; sodium lactate: 0.1 percent; phenoxyethanol: 0.1 percent; xanthan gum: 0.1 percent; ethyl hexyl glycerin: 0.1 percent; the rest is: water; the hyaluronic acid nanoemulsion gel exists in a solution in the form of nano-scale particles or liquid drops or inclusions, and has the beneficial effects that: the functional components of the hyaluronic acid nanoemulsion gel in a nanoemulsion preparation mode can be wrapped by oily components and uniformly dispersed in a water phase; due to the existence of the wrapping layer, the contact probability of the hyaluronic acid nanoemulsion gel and water molecules can be effectively reduced, the stabilization period of the hyaluronic acid nanoemulsion gel in an aqueous solution is greatly prolonged, and the product application range of the hyaluronic acid nanoemulsion gel is greatly expanded.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of biology, in particular to a hyaluronic acid nanoemulsion gel for nursing female vagina.
[ background of the invention ]
At present, female private products sold in China mainly comprise various lotion, and even if the vagina is not suitable for cleaning and is only washed by clear water, the loss of flora, the loss of nutrient components (such as glycogen, lactic acid, salt and the like) and the change of the pH value of the vagina are caused, so that the maintenance of a good and healthy microbial environment is not facilitated;
the domestic products sold in the market mostly adopt the sterilization and bacteriostasis components of traditional Chinese medicines, plants and the like to achieve the effects of cleaning and relieving itching, but simultaneously kill various beneficial lactobacilli, so that the vaginal microorganism environment is unbalanced and is more easily infected by harmful bacteria;
the domestic market products only consider that the pH value of the vagina is acidic (the pH value is more than or equal to 3.8 and less than or equal to 4.5), but do not consider the nutrient environment really suitable for the growth of the vaginal flora, and have no corresponding means for glycogen, salt, moist environment and the like required by the growth of lactobacillus;
the product is emphasized in appearance and not emphasized in safety, for example, the commercially available product is added with a large amount of: essence components for improving odor, surfactant components for improving cleaning ability, and lubricant components for increasing lubricity and compactness, which are components unfavorable to the healthy microbial environment of vagina, even irritate vaginal epithelial tissue, cause allergy, inflammation, etc.;
in the vagina of a female reproductive system, the vagina can be infected by pathogens due to various reasons, or the vagina environment changes due to the problems of flora balance and acid-base balance of the vagina, so that vaginal bleeding or various gynecological diseases are caused, and from the point of traditional Chinese medicine, the etiology and pathogenesis of the fungal vaginosis are mainly due to spleen deficiency and dampness generation and dampness deposition in the lower jiao; the disease cause of trichomonas vaginitis is mainly caused by stagnated heat of liver channel and latent heat imago; the pathogenesis of the senile vaginitis is mainly liver-kidney yin deficiency and downward flow of damp-heat, the vaginitis is mainly considered to be caused by virus or germ infection in western medicine, and long-term health and life troubles are brought to women, even the psychological health is seriously influenced.
[ summary of the invention ]
The invention aims to solve the problems that the vagina of a female reproductive system is infected by pathogens due to various reasons, or the environment of the vagina is changed due to the balance of flora and acid-base balance of the vagina, so that the vagina is subjected to bleeding or various gynecological diseases, and provides a novel hyaluronic acid nanoemulsion gel for nursing the female vagina.
The invention is realized by the following technical scheme:
a hyaluronic acid nanoemulsion gel for nursing female vagina comprises the following main components in percentage by weight:
glycerol: 6 to 8 percent;
lactic acid: 0.5-1.5%;
sodium hyaluronate: 0.5-1.5%;
sodium lactate: 0.1 to 1.0 percent;
phenoxyethanol: 0.1 to 1.0 percent;
xanthan gum: 0.1 to 0.50 percent;
ethyl hexyl glycerin: 0.1 to 0.50 percent;
the rest is: water;
the hyaluronic acid nanoemulsion gel exists in the form of nano-scale particles or liquid drops or inclusion bodies in a solution.
Further, the weight percentage of the water is 88-92%.
Further, the limit value of phenoxyethanol is 1%.
Further, the hyaluronic acid nanoemulsion gel consists of a hyaluronic acid composition and a nanoemulsion gel, wherein the hyaluronic acid composition consists of hyaluronic acid, oleanolic acid and European plum (PRUNUS DOMESTICA) fruit extract; the nano-emulsion gel consists of an oil phase, a surfactant, a cosurfactant and a gel matrix; the surfactants and co-surfactants may be: tween 40, tween 60, tween 80 or span 40, span 60, span 80.
Further, the surfactant is an anionic surfactant and a nonionic surfactant.
Further, the hyaluronic acid comprises the following components in percentage by weight: 10 to 20 percent; the oleanolic acid comprises the following components in percentage by weight: 3 to 7 percent; the weight percentage of the European plum (PRUNUS DOMESTICA) fruit extract is as follows: 1 to 5 percent.
Further, the oil phase comprises the following components in percentage by weight: 0.5-1.5%; the weight percentage of the surfactant is as follows: 6 to 15 percent; the weight percentage of the cosurfactant is as follows: 8 to 15 percent; the gel matrix comprises the following components in percentage by weight: 0.1 to 0.5 percent.
Further, the surfactant: the compound is a substance which has fixed hydrophilic and lipophilic groups, can be directionally arranged on the surface of a solution and can obviously reduce the surface tension; the type and dosage of the surfactant in the nanoemulsion directly influence whether the nanoemulsion can be formed and the toxicity of the nanoemulsion, and the HLB value of the surfactant forms O/W type nanoemulsion when the HLB value is 8-18 and forms W/O type nanoemulsion when the HLB value is 4-7.
Further, the co-surfactant: the cosurfactant can reduce the interfacial tension, promote the dissolution of the drug, reduce the interfacial tension and the charge repulsion, and adjust the HLB value of the surfactant, thereby promoting the formation of the nanoemulsion and increasing the stability of the nanoemulsion.
A preparation method of hyaluronic acid nanoemulsion gel for female vaginal care comprises the following steps:
s1: mixing and dissolving lactic acid, sodium hyaluronate, sodium lactate and glycerol to obtain an oil phase;
s2: mixing phenoxyethanol, xanthan gum and ethylhexyl glycerin with water to obtain a water phase;
s3: and (4) stirring and mixing the water phase obtained in the step S2 and the oil phase obtained in the step S1 to obtain the hyaluronic acid nano-emulsion gel.
Further, the filling material of the hyaluronic acid nano-emulsion gel comprises transparent hyaluronic acid gel and cross-linked hyaluronic acid gel, wherein the weight percentages of the transparent hyaluronic acid gel and the cross-linked hyaluronic acid gel are as follows: 10 to 40 percent; the chemical formula of the cross-linked hyaluronic acid gel is as follows:
the cross-linked hyaluronic acid gel is formed by bonding hyaluronic acid and polyethylene glycol through ester bonds, and a reticular structure formed by the cross-linked hyaluronic acid gel is well attached to the vaginal wall, can play a role in relieving contained nutrient components, can continuously supply nutrients to flora for a long time, and injects nutrient components required by vaginal flora into the reticular structure to simulate naturally secreted mucus of vagina.
The invention has the beneficial effects that:
(1) the functional components of the hyaluronic acid nanoemulsion gel in a nanoemulsion preparation mode can be wrapped by oily components and uniformly dispersed in a water phase; due to the existence of the coating layer, the contact probability of the hyaluronic acid nanoemulsion gel and water molecules can be effectively reduced, the stable period of the hyaluronic acid nanoemulsion gel in an aqueous solution is greatly prolonged, and the product application range of the hyaluronic acid nanoemulsion gel is greatly expanded;
(2) after this patent application product gets into the vagina, can spread to the affected part rapidly, destroy harmful bacteria's living environment, adjust the flora balance and the acid-base balance in the vagina, hyaluronic acid nanoemulsion gel active ingredient is coordinating the composition of macromolecular structures such as glycerine, lactic acid, hyaluronic acid sodium, lactic acid sodium, the vagina mucous membrane is deepened in easy infiltration, repair damaged tissue and then progressively clear up attached to bacterium, the fungus in the vagina, make the autoimmune of vagina obtain recovering gradually, simultaneously can also fabulous moist vagina.
[ description of the drawings ]
FIG. 1 is a schematic view of a network structure formed by the crosslinked hyaluronic acid gel of the present invention;
[ detailed description ] embodiments
The invention is further described with reference to the accompanying drawings and the detailed description:
example 1:
a hyaluronic acid nanoemulsion gel for nursing female vagina comprises the following main components in percentage by weight:
glycerol: 6 percent;
lactic acid: 0.5 percent;
sodium hyaluronate: 0.5 percent;
sodium lactate: 0.1 percent;
phenoxyethanol: 0.1 percent;
xanthan gum: 0.1 percent;
ethyl hexyl glycerin: 0.1 percent;
the rest is: water;
the hyaluronic acid nanoemulsion gel exists in the form of nano-scale particles or liquid drops or inclusion bodies in a solution.
Preferably, the water is 88% by weight.
Preferably, the limit value of phenoxyethanol is 1%.
Preferably, the hyaluronic acid nanoemulsion gel consists of a hyaluronic acid composition consisting of hyaluronic acid, oleanolic acid, and PRUNUS DOMESTICA (PRUNUS DOMESTICA) fruit extract; the nano-emulsion gel consists of an oil phase, a surfactant, a cosurfactant and a gel matrix; the surfactants and co-surfactants may be: tween 40, tween 60, tween 80 or span 40, span 60, span 80.
Preferably, the surfactants are anionic surfactants and nonionic surfactants.
Preferably, the hyaluronic acid comprises the following components in percentage by weight: 10 percent; the oleanolic acid comprises the following components in percentage by weight: 3 percent; the weight percentage of the European plum (PRUNUS DOMESTICA) fruit extract is as follows: 1 percent.
Preferably, the oil phase comprises the following components in percentage by weight: 0.5 percent; the weight percentage of the surfactant is as follows: 6 percent; the weight percentage of the cosurfactant is as follows: 8 percent; the gel matrix comprises the following components in percentage by weight: 0.1 percent.
Preferably, the surfactant: the compound is a substance which has fixed hydrophilic and lipophilic groups, can be directionally arranged on the surface of a solution and can obviously reduce the surface tension; the type and dosage of the surfactant in the nanoemulsion directly influence whether the nanoemulsion can be formed and the toxicity of the nanoemulsion, and the HLB value of the surfactant forms O/W type nanoemulsion when the HLB value is 8-18 and forms W/O type nanoemulsion when the HLB value is 4-7.
A preparation method of hyaluronic acid nanoemulsion gel for female vaginal care comprises the following steps:
s1: mixing and dissolving lactic acid, sodium hyaluronate, sodium lactate and glycerol to obtain an oil phase;
s2: mixing phenoxyethanol, xanthan gum and ethylhexyl glycerin with water to obtain a water phase;
s3: and (4) stirring and mixing the water phase obtained in the step S2 and the oil phase obtained in the step S1 to obtain the hyaluronic acid nano-emulsion gel.
Further, the filling material of the hyaluronic acid nano-emulsion gel comprises transparent hyaluronic acid gel and cross-linked hyaluronic acid gel, wherein the weight percentages of the transparent hyaluronic acid gel and the cross-linked hyaluronic acid gel are as follows: 10 to 40 percent; the chemical formula of the cross-linked hyaluronic acid gel is as follows:
the cross-linked hyaluronic acid gel is formed by bonding hyaluronic acid and polyethylene glycol through ester bonds, and a reticular structure formed by the cross-linked hyaluronic acid gel is well attached to the vaginal wall, can play a role in relieving contained nutrient components, can continuously supply nutrients to flora for a long time, and injects nutrient components required by vaginal flora into the reticular structure to simulate naturally secreted mucus of vagina.
Urban and rural 1792 adult female colpitis incidence survey is as follows:
example 2:
a hyaluronic acid nanoemulsion gel for nursing female vagina comprises the following main components in percentage by weight:
glycerol: 6.5 percent;
lactic acid: 1 percent;
sodium hyaluronate: 1 percent;
sodium lactate: 0.8 percent;
phenoxyethanol: 0.6 percent;
xanthan gum: 0.30 percent;
ethyl hexyl glycerin: 0.30 percent;
the rest is: water;
the hyaluronic acid nanoemulsion gel exists in the form of nano-scale particles or liquid drops or inclusion bodies in a solution.
Preferably, the water is present in an amount of 90% by weight.
Preferably, the limit value of phenoxyethanol is 1%.
Preferably, the hyaluronic acid nanoemulsion gel consists of a hyaluronic acid composition consisting of hyaluronic acid, oleanolic acid, and PRUNUS DOMESTICA (PRUNUS DOMESTICA) fruit extract; the nano-emulsion gel consists of an oil phase, a surfactant, a cosurfactant and a gel matrix; the surfactants and co-surfactants may be: tween 40, tween 60, tween 80 or span 40, span 60, span 80.
Preferably, the hyaluronic acid comprises the following components in percentage by weight: 15 percent; the oleanolic acid comprises the following components in percentage by weight: 4.5 percent; the weight percentage of the European plum (PRUNUS DOMESTICA) fruit extract is as follows: 3.5 percent.
Preferably, the oil phase comprises the following components in percentage by weight: 1.0 percent; the weight percentage of the surfactant is as follows: 12.5 percent; the weight percentage of the cosurfactant is as follows: 12.5 percent; the gel matrix comprises the following components in percentage by weight: 0.35 percent.
Preferably, the surfactant: the compound is a substance which has fixed hydrophilic and lipophilic groups, can be directionally arranged on the surface of a solution and can obviously reduce the surface tension; the type and dosage of the surfactant in the nanoemulsion directly influence whether the nanoemulsion can be formed and the toxicity of the nanoemulsion, and the HLB value of the surfactant forms O/W type nanoemulsion when the HLB value is 8-18 and forms W/O type nanoemulsion when the HLB value is 4-7.
A preparation method of hyaluronic acid nanoemulsion gel for female vaginal care comprises the following steps:
s1: mixing and dissolving lactic acid, sodium hyaluronate, sodium lactate and glycerol to obtain an oil phase;
s2: mixing phenoxyethanol, xanthan gum and ethylhexyl glycerin with water to obtain a water phase;
s3: and (4) stirring and mixing the water phase obtained in the step S2 and the oil phase obtained in the step S1 to obtain the hyaluronic acid nano-emulsion gel.
Example 3:
a hyaluronic acid nanoemulsion gel for nursing female vagina comprises the following main components in percentage by weight:
glycerol: 8 percent;
lactic acid: 1.5 percent;
sodium hyaluronate: 1.5 percent;
sodium lactate: 1.0 percent;
phenoxyethanol: 1.0 percent;
xanthan gum: 0.50 percent;
ethyl hexyl glycerin: 0.50 percent;
the rest is: water;
the hyaluronic acid nanoemulsion gel exists in the form of nano-scale particles or liquid drops or inclusion bodies in a solution.
Preferably, the water is present in an amount of 92% by weight.
Preferably, the limit value of phenoxyethanol is 1%.
Preferably, the hyaluronic acid nanoemulsion gel consists of a hyaluronic acid composition consisting of hyaluronic acid, oleanolic acid, and PRUNUS DOMESTICA (PRUNUS DOMESTICA) fruit extract; the nano-emulsion gel consists of an oil phase, a surfactant, a cosurfactant and a gel matrix; the surfactants and co-surfactants may be: tween 40, tween 60, tween 80 or span 40, span 60, span 80.
Preferably, the hyaluronic acid comprises the following components in percentage by weight: 20 percent; the oleanolic acid comprises the following components in percentage by weight: 7 percent; the weight percentage of the European plum (PRUNUS DOMESTICA) fruit extract is as follows: 5 percent.
Preferably, the oil phase comprises the following components in percentage by weight: 1.5 percent; the weight percentage of the surfactant is as follows: 15 percent; the weight percentage of the cosurfactant is as follows: 15 percent; the gel matrix comprises the following components in percentage by weight: 0.5 percent.
Preferably, the surfactant: the compound is a substance which has fixed hydrophilic and lipophilic groups, can be directionally arranged on the surface of a solution and can obviously reduce the surface tension; the type and dosage of the surfactant in the nanoemulsion directly influence whether the nanoemulsion can be formed and the toxicity of the nanoemulsion, and the HLB value of the surfactant forms O/W type nanoemulsion when the HLB value is 8-18 and forms W/O type nanoemulsion when the HLB value is 4-7.
A preparation method of hyaluronic acid nanoemulsion gel for female vaginal care comprises the following steps:
s1: mixing and dissolving lactic acid, sodium hyaluronate, sodium lactate and glycerol to obtain an oil phase;
s2: mixing phenoxyethanol, xanthan gum and ethylhexyl glycerin with water to obtain a water phase;
s3: and (4) stirring and mixing the water phase obtained in the step S2 and the oil phase obtained in the step S1 to obtain the hyaluronic acid nano-emulsion gel.
The analysis of vaginitis causes in women of different ages is investigated as follows in Table 2:
example 4:
as shown in fig. 1, hyaluronic acid molecules are subjected to cross-linking treatment to form a network structure, so that the inclusion and adhesion of gel are improved; the reticular structure formed by the cross-linked hyaluronic acid gel is well attached to the vaginal wall, can play a role in relieving contained nutrient components, continuously supplies nutrients to flora for a long time, injects nutrient components required by vaginal flora into the reticular structure, and simulates mucus naturally secreted by vagina.
Preferably, the nutritional components include glycogen, lactic acid and small amounts of salts required for growth of lactobacillus, micro-molecular hyaluronic acid, collagen, fibroin and oily components for repair of vaginal epithelial tissue.
Appropriate changes and modifications to the embodiments described above will become apparent to those skilled in the art from the disclosure and teachings of the foregoing description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.
Claims (10)
1. A hyaluronic acid nanoemulsion gel for nursing female vagina is characterized in that: the hyaluronic acid nanoemulsion gel comprises the following main components in percentage by weight:
glycerol: 6 to 8 percent;
lactic acid: 0.5-1.5%;
sodium hyaluronate: 0.5-1.5%;
sodium lactate: 0.1 to 1.0 percent;
phenoxyethanol: 0.1 to 1.0 percent;
xanthan gum: 0.1 to 0.50 percent;
ethyl hexyl glycerin: 0.1 to 0.50 percent;
the rest is: water;
the hyaluronic acid nanoemulsion gel exists in the form of nano-scale particles or liquid drops or inclusion bodies in a solution.
2. Hyaluronic acid nanoemulsion gel for female vaginal care according to claim 1, characterized in that: the weight percentage of the water is 88-92%.
3. Hyaluronic acid nanoemulsion gel for female vaginal care according to claim 1, characterized in that: the limit value of the phenoxyethanol is 1%.
4. Hyaluronic acid nanoemulsion gel for female vaginal care according to claim 1, characterized in that: the hyaluronic acid nanoemulsion gel consists of a hyaluronic acid composition and a nanoemulsion gel, wherein the hyaluronic acid composition consists of hyaluronic acid, oleanolic acid and European Plum (PRUNUSDOMESTICA) fruit extract; the nano-emulsion gel consists of an oil phase, a surfactant, a cosurfactant and a gel matrix;
the surfactants and co-surfactants may be: tween 40, tween 60, tween 80 or span 40, span 60, span 80;
the surfactant is anionic surfactant and nonionic surfactant.
5. The hyaluronic acid nanoemulsion gel for female vaginal care according to claim 4, characterized in that the hyaluronic acid in weight percentage is: 10 to 20 percent; the oleanolic acid comprises the following components in percentage by weight: 3 to 7 percent; the weight percentage of the European Plum (PRUNUSDOMESTICA) fruit extract is as follows: 1 to 5 percent.
6. The hyaluronic acid nanoemulsion gel for female vaginal care according to claim 4, characterized in that the oil phase comprises, in percentages by weight: 0.5-1.5%; the weight percentage of the surfactant is as follows: 6 to 15 percent; the weight percentage of the cosurfactant is as follows: 8 to 15 percent; the gel matrix comprises the following components in percentage by weight: 0.1 to 0.5 percent.
7. Hyaluronic acid nanoemulsion gel for feminine vaginal care according to claim 4, characterized in that: the surfactant is a substance which has fixed hydrophilic and lipophilic groups, can be directionally arranged on the surface of the solution and can obviously reduce the surface tension; the type and dosage of the surfactant in the nanoemulsion directly influence whether the nanoemulsion can be formed and the toxicity of the nanoemulsion, and the HLB value of the surfactant forms O/W type nanoemulsion when the HLB value is 8-18 and forms W/O type nanoemulsion when the HLB value is 4-7.
8. Hyaluronic acid nanoemulsion gel for feminine vaginal care according to claim 4, characterized in that: the cosurfactant can reduce interfacial tension, promote drug dissolution, reduce interfacial tension and charge repulsion, and adjust the HLB value of the surfactant, thereby promoting nanoemulsion formation and increasing the stability of the nanoemulsion.
9. The preparation method of hyaluronic acid nanoemulsion gel for female vaginal care according to claim 1, characterized by comprising the following steps:
s1: mixing and dissolving lactic acid, sodium hyaluronate, sodium lactate and glycerol to obtain an oil phase;
s2: mixing phenoxyethanol, xanthan gum and ethylhexyl glycerin with water to obtain a water phase;
s3: and (4) stirring and mixing the water phase obtained in the step S2 and the oil phase obtained in the step S1 to obtain the hyaluronic acid nano-emulsion gel.
10. Hyaluronic acid nanoemulsion gel for female vaginal care according to claim 1, characterized in that: the filling material of the hyaluronic acid nano-emulsion gel comprises transparent hyaluronic acid gel and cross-linked hyaluronic acid gel, wherein the weight percentages of the transparent hyaluronic acid gel and the cross-linked hyaluronic acid gel are as follows: 10 to 40 percent; the chemical formula of the cross-linked hyaluronic acid gel is as follows:
the cross-linked hyaluronic acid gel is formed by bonding hyaluronic acid and polyethylene glycol through ester bonds, and a reticular structure formed by the cross-linked hyaluronic acid gel is well attached to the vaginal wall, can play a role in relieving contained nutrient components, can continuously supply nutrients to flora for a long time, and injects nutrient components required by vaginal flora into the reticular structure to simulate naturally secreted mucus of vagina.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023287309A1 (en) * | 2021-07-16 | 2023-01-19 | Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu | Pharmaceutical composition in the form of vegetable oil-based nanoemulsion, multiphase composition and method of preparation of these compositions |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142461A (en) * | 2013-01-25 | 2013-06-12 | 中国人民解放军军事医学科学院微生物流行病研究所 | Gel for vaginas and preparation method thereof |
| CN103316033A (en) * | 2013-07-03 | 2013-09-25 | 康晓飞 | Gel and use thereof |
| CN104548071A (en) * | 2015-01-27 | 2015-04-29 | 太原锦波生物医药科技有限公司 | Recombinant human-derived collagen vagina gel for vaginal dryness and preparation method thereof |
| CN110151640A (en) * | 2019-07-09 | 2019-08-23 | 华欧研创生物科技(深圳)有限公司 | A kind of sodium hyaluronate composition and its nanometer formulation based on beautifying use |
-
2019
- 2019-10-09 CN CN201910952962.XA patent/CN110664733A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142461A (en) * | 2013-01-25 | 2013-06-12 | 中国人民解放军军事医学科学院微生物流行病研究所 | Gel for vaginas and preparation method thereof |
| CN103316033A (en) * | 2013-07-03 | 2013-09-25 | 康晓飞 | Gel and use thereof |
| CN104548071A (en) * | 2015-01-27 | 2015-04-29 | 太原锦波生物医药科技有限公司 | Recombinant human-derived collagen vagina gel for vaginal dryness and preparation method thereof |
| CN110151640A (en) * | 2019-07-09 | 2019-08-23 | 华欧研创生物科技(深圳)有限公司 | A kind of sodium hyaluronate composition and its nanometer formulation based on beautifying use |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023287309A1 (en) * | 2021-07-16 | 2023-01-19 | Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu | Pharmaceutical composition in the form of vegetable oil-based nanoemulsion, multiphase composition and method of preparation of these compositions |
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