CN110662747A - Janus激酶抑制剂的葡糖苷酸前药 - Google Patents
Janus激酶抑制剂的葡糖苷酸前药 Download PDFInfo
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- CN110662747A CN110662747A CN201880034623.7A CN201880034623A CN110662747A CN 110662747 A CN110662747 A CN 110662747A CN 201880034623 A CN201880034623 A CN 201880034623A CN 110662747 A CN110662747 A CN 110662747A
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- compound
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- trifluoromethyl
- hydrogen
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- LWGWFQMZZSYANO-UHFFFAOYSA-N tert-butyl n-methyl-n-[(2-nitrophenyl)methyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C)CC1=CC=CC=C1[N+]([O-])=O LWGWFQMZZSYANO-UHFFFAOYSA-N 0.000 description 1
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- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
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- UJLAWZDWDVHWOW-YPMHNXCESA-N tofacitinib Chemical compound C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)C1=NC=NC2=C1C=CN2 UJLAWZDWDVHWOW-YPMHNXCESA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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- 229950007217 tremelimumab Drugs 0.000 description 1
- 125000005591 trimellitate group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762509847P | 2017-05-23 | 2017-05-23 | |
| US62/509,847 | 2017-05-23 | ||
| PCT/US2018/033818 WO2018217700A1 (en) | 2017-05-23 | 2018-05-22 | Glucuronide prodrugs of janus kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110662747A true CN110662747A (zh) | 2020-01-07 |
Family
ID=62621001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880034623.7A Pending CN110662747A (zh) | 2017-05-23 | 2018-05-22 | Janus激酶抑制剂的葡糖苷酸前药 |
Country Status (14)
| Country | Link |
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| US (2) | US10745405B2 (enExample) |
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Cited By (3)
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| CN111196831A (zh) * | 2020-01-20 | 2020-05-26 | 山西医科大学 | 一种呋喃酚葡萄糖醛酸结合物的制备方法 |
| CN115073543A (zh) * | 2022-07-20 | 2022-09-20 | 北京普祺医药科技股份有限公司 | 一种jak抑制剂的化合物前药及其制备与应用 |
| WO2023155905A1 (zh) * | 2022-02-21 | 2023-08-24 | 上海岸阔医药科技有限公司 | 化合物及其用途 |
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| CN111094314B (zh) * | 2018-08-15 | 2022-08-12 | 江苏豪森药业集团有限公司 | 含有葡糖苷酸衍生物jak抑制剂的前药及其制备方法和应用 |
| WO2023018954A1 (en) * | 2021-08-12 | 2023-02-16 | Concert Pharmaceuticals, Inc. | Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors |
| EP4507691A2 (en) * | 2022-04-15 | 2025-02-19 | The Regents Of The University Of Michigan | Jak inhibitor analogs, formulations, and uses thereof |
| WO2024133631A1 (en) | 2022-12-22 | 2024-06-27 | Krka, D.D., Novo Mesto | Veterinary composition comprising oclacitinib |
| WO2024148049A1 (en) * | 2023-01-04 | 2024-07-11 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
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- 2018-05-22 KR KR1020197037814A patent/KR20200010440A/ko not_active Withdrawn
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- 2018-05-22 AU AU2018273866A patent/AU2018273866B2/en not_active Expired - Fee Related
- 2018-05-22 CN CN201880034623.7A patent/CN110662747A/zh active Pending
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| CN111196831A (zh) * | 2020-01-20 | 2020-05-26 | 山西医科大学 | 一种呋喃酚葡萄糖醛酸结合物的制备方法 |
| CN111196831B (zh) * | 2020-01-20 | 2023-05-09 | 山西医科大学 | 一种呋喃酚葡萄糖醛酸结合物的制备方法 |
| WO2023155905A1 (zh) * | 2022-02-21 | 2023-08-24 | 上海岸阔医药科技有限公司 | 化合物及其用途 |
| CN115073543A (zh) * | 2022-07-20 | 2022-09-20 | 北京普祺医药科技股份有限公司 | 一种jak抑制剂的化合物前药及其制备与应用 |
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| PH12019502605A1 (en) | 2020-10-26 |
| AU2018273866A1 (en) | 2019-12-19 |
| RU2019142472A3 (enExample) | 2021-09-23 |
| WO2018217700A1 (en) | 2018-11-29 |
| BR112019024509A2 (pt) | 2020-06-23 |
| NZ759764A (en) | 2022-07-01 |
| RU2019142472A (ru) | 2021-06-24 |
| US20180339990A1 (en) | 2018-11-29 |
| IL270693A (en) | 2020-01-30 |
| CA3063963A1 (en) | 2018-11-29 |
| AU2018273866B2 (en) | 2021-09-30 |
| EP3609899A1 (en) | 2020-02-19 |
| KR20200010440A (ko) | 2020-01-30 |
| JP2020520955A (ja) | 2020-07-16 |
| MX2019014054A (es) | 2020-02-05 |
| US10745405B2 (en) | 2020-08-18 |
| US20210032250A1 (en) | 2021-02-04 |
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