CN110638866B - Antioxidant and anti-aging soft capsule - Google Patents
Antioxidant and anti-aging soft capsule Download PDFInfo
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- CN110638866B CN110638866B CN201910787451.7A CN201910787451A CN110638866B CN 110638866 B CN110638866 B CN 110638866B CN 201910787451 A CN201910787451 A CN 201910787451A CN 110638866 B CN110638866 B CN 110638866B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Abstract
The invention discloses an antioxidant and anti-aging soft capsule, the content of which comprises the following components in parts by weight: 32-64 parts of hemp seed oil, 18-36 parts of snake oil, 6-16 parts of vitamins and 8-18 parts of nutritional ingredients. The invention prepares the plant hemp seed oil and the animal snake oil into the soft capsule, integrates the nutritive value and the medicinal value of the plant oil and the animal oil, makes up the defects of the plant oil and the animal oil through mutual matching, has good oxidation resistance and anti-aging functions, and is a great innovation in the health food industry.
Description
Technical Field
The invention relates to a functional health food, in particular to a health soft capsule which takes hemp seed oil and snake oil as main raw materials and other nutritional ingredients as auxiliary materials.
Background
Hemp seed oil, which is extracted from hemp seeds, is called longevity oil by local palms. The hemp seed oil is the only oil which can be dissolved in water in nature, has the highest content of unsaturated fatty acid in all vegetable oils, simultaneously contains a large amount of vitamin E, selenium, zinc, manganese and germanium for delaying senility, also contains alpha-linolenic acid known as 'vegetable brain gold', is the plant which is found to be the most effective for resisting senility and radiation so far, and is called 'longevity hemp' or 'non-old oil'.
Snake oil is fat stripped from snake body during laparotomy, and is obtained by decocting. The snake oil is composed of a plurality of fatty acids, contains saturated fatty acids and unsaturated fatty acids, wherein the content of the unsaturated fatty acids is about 68%, the snake oil contains oleic acid, linoleic acid, linolenic acid and the like, and is also rich in dicarbopolyenoic acids which are not contained in vegetable oil, such as eicosapentaenoic acid, docosahexaenoic acid and the like, and the eicosapentaenoic acid and the docosahexaenoic acid can promote the formation of brain/retina, delay the aging of the brain, prevent the accumulation of cholesterol and prevent cardiovascular diseases. In addition, the product also contains a great amount of trace elements for delaying senility, particularly selenium element, and the content is as high as 0.428 mu g/g.
However, at present, no use mode of compounding the hemp seed oil and the snake oil exists.
Disclosure of Invention
The invention aims to provide an antioxidant and anti-aging soft capsule.
In order to solve the technical problems, the invention provides an antioxidant and anti-aging soft capsule, the content of which comprises the following components in parts by weight: 32-64 parts of hemp seed oil, 18-36 parts of snake oil, 6-16 parts of vitamins and 8-18 parts of nutritional ingredients.
The improvement of the antioxidant and anti-aging soft capsule of the invention is as follows: the content of the soft capsule consists of the following components in parts by weight: 40-58 parts of hemp seed oil, 24-32 parts of snake oil, 8-12 parts of vitamins and 10-17 parts of nutritional ingredients.
As a further improvement of the antioxidant and anti-aging soft capsule of the invention: the vitamin is at least one of vitamin A, vitamin C, vitamin D and vitamin E (namely, any one or combination of several kinds of vitamins).
As a further improvement of the antioxidant and anti-aging soft capsule of the invention: the nutrient components consist of calcium, magnesium, zinc and iron; the calcium is calcium carbonate, the magnesium is magnesium sulfate, the zinc is zinc citrate, and the iron is ferrous sulfate.
As a further improvement of the antioxidant and anti-aging soft capsule of the invention: the vitamins comprise 1.0-1.8 parts of vitamin A, 0.4-1.0 part of vitamin C, 0.6-1.2 parts of vitamin D and 6-8 parts of vitamin E.
As a further improvement of the antioxidant and anti-aging soft capsule of the invention: the nutrient components comprise 3-5 parts of calcium carbonate, 4-6 parts of magnesium sulfate, 1-2 parts of zinc citrate and 2-4 parts of ferrous sulfate.
The preparation method of the soft capsule shell belongs to the known conventional technology.
The invention is a soft capsule prepared by mixing hemp seed oil (rich in unsaturated fatty acid and trace elements) and snake oil (rich in dienoic acid and trace elements) as main materials, vitamins and other nutrient components according to a certain proportion.
In the present invention, all the ingredients can be obtained in a conventional commercially available form, for example, hemp seed oil is super hemp seed oil produced by Guangxi Bama yaoshutang health and longevity industries, Inc., and snake oil is No. 15 snake oil produced by Naja technologies, Inc., Yongzhou.
The contents of the soft capsule prepared by the invention are mainly plant hemp seed oil and animal snake oil, on one hand, the soft capsule makes up the defect of single plant oil or animal oil through mutual matching, and has good oxidation resistance and anti-aging functions. Meanwhile, the health-care tea has the effects of nourishing and tonifying deficiency, maintaining beauty and keeping young, delaying arteriosclerosis, preventing cardiovascular and cerebrovascular diseases, improving intestinal discomfort and the like; on the other hand, the prepared soft capsule can cover various peculiar smells of the hemp oil and the fishy smell of the snake oil; the oil is prevented from being directly contacted with light, moist and hot air, and the stability of the oil is improved; convenient taking, carrying and storage, accurate dosage, simple production process and small technical difficulty.
In conclusion, the invention prepares the plant hemp seed oil and the animal snake oil into the soft capsule, integrates the nutritive value and the medicinal value of the plant oil and the animal oil, makes up the defects of the plant oil and the animal oil through mutual matching, and has good oxidation resistance and anti-aging functions.
The use method and the dosage of the soft capsule of the invention are as follows: orally taken, 0.5-1.0 g/person for a day.
Detailed Description
The purpose, technical solution and advantages of the present invention will be more clearly understood through the following detailed description of the present invention with reference to the embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1, a method for preparing an antioxidant and anti-aging soft capsule, sequentially comprising the following steps:
1) and preparing contents:
the content of the soft capsule consists of the following components in parts by weight: 58 parts of hemp seed oil, 24 parts of snake oil, 8 parts of vitamin and 10 parts of nutrient components. Wherein 8 parts of vitamin comprises 1.0 part of vitamin A, 0.4 part of vitamin C, 0.6 part of vitamin D and 6 parts of vitamin E, and 10 parts of nutrient comprises 3 parts of calcium carbonate, 4 parts of magnesium sulfate, 1 part of zinc citrate and 2 parts of ferrous sulfate.
Heating snake oil (about 50 deg.C) to melt, adding oleum Cannabis, stirring, adding vitamins and nutrients, and stirring.
2) Making capsule body (this is known technology): the capsule material is prepared by taking purified water, edible gelatin and glycerol as capsule raw materials, injecting 18 parts of glycerol and 41 parts of purified water into a sol tank, heating and stirring to 70-75 ℃, adding 41 parts of gelatin, continuously stirring for 30 minutes, and performing vacuum defoaming.
3) And pressing the prepared content and the capsule body into the finished soft capsule.
Example 2, a method for preparing an antioxidant, anti-aging soft capsule:
the content of the soft capsule consists of the following components in parts by weight: 40 parts of hemp seed oil, 32 parts of snake oil, 12 parts of vitamin and 16 parts of nutrient components. Wherein the vitamin 12 parts consists of 1.8 parts of vitamin A, 1 part of vitamin C, 1.2 parts of vitamin D and 8 parts of vitamin E, and the nutrient component 16 parts consists of 5 parts of calcium carbonate, 6 parts of magnesium sulfate, 1 part of zinc citrate and 4 parts of ferrous sulfate.
The rest is equivalent to embodiment 1.
Example 3, a method for preparing an antioxidant, anti-aging soft capsule,
the content of the soft capsule consists of the following components in parts by weight: 49 parts of hemp seed oil, 28 parts of snake oil, 10 parts of vitamins and 13 parts of nutritional ingredients. Wherein 10 parts of vitamin comprises 1.4 parts of vitamin A, 0.7 part of vitamin C, 0.9 part of vitamin D and 7 parts of vitamin E, and 13 parts of nutrient comprises 4 parts of calcium carbonate, 5 parts of magnesium sulfate, 1 part of zinc citrate and 3 parts of ferrous sulfate.
Experiment, the soft capsules obtained in examples 1 to 3 were tested according to the following method:
the detection method comprises the following steps: 24 mice with natural aging (basically consistent aging degree) are selected, and 6 mice in each group are set as an aged mouse control group, a soft capsule group obtained in example 1, a soft capsule group obtained in example 2 and a soft capsule group obtained in example 3. All mice were acclimatized for one week. The soft capsule group is administered with 4.0 g/kg-1 · d -1. The control group of aged mice was given an equal weight of physiological saline for 30 days. On day 30, fasting is carried out for 12 h, the eyeball is picked up and blood is taken, and superoxide dismutase (SOD) in the serum is detected and averaged.
The results of the measurements are shown in Table 1 below.
TABLE 1
| Control group of aged mice | Example 1 | Example 2 | Example 3 | |
| SOD / U· g-1 | 236 | 482 | 413 | 436 |
The results show that the soft capsule can obviously improve the activity of antioxidant enzyme in the aged mice, thereby eliminating excessive free radicals generated by organisms in the metabolic process and inhibiting the aging of the organisms.
Comparative example 1-1, the use of snake oil was eliminated (i.e., snake oil was 0 parts), and hemp seed oil was changed from 58 parts to 82 parts; the rest is equivalent to embodiment 1.
Comparative examples 1-2, in which the use of hemp seed oil was eliminated (i.e., hemp seed oil was 0 parts), 24 parts of snake oil was changed to 82 parts, and the rest was the same as in example 1.
Comparative examples 1 to 3, the hemp seed oil 58 parts and the snake oil 24 parts are changed into the hemp seed oil 30 parts and the snake oil 52 parts; the rest is equivalent to embodiment 1.
Comparative examples 1 to 4, the hemp seed oil 58 parts and the snake oil 24 parts are changed into the hemp seed oil 70 parts and the snake oil 12 parts; the rest is equivalent to embodiment 1.
Comparative example 2-1, the use of vitamins in example 1 was eliminated, and the nutritional ingredients were changed from 10 parts to 18 parts, and the nutritional ingredients were calcium carbonate, magnesium sulfate, zinc citrate, ferrous sulfate in a ratio of 3: 4: 1: 2 (the same weight ratio as in example 1); the rest is equivalent to embodiment 1.
Comparative example 2-2, the use of the nutrients in example 1 was eliminated, and the vitamins were changed from 8 parts to 18 parts, the vitamins being vitamin a, vitamin C, vitamin D and vitamin E in the ratio of 1.0: 0.4: 0.6: 6 (the same weight ratio as in example 1); the rest is equivalent to embodiment 1.
Comparative experiment: the soft capsules obtained in the above comparative examples were tested according to the methods described in the above experiments, and the results are shown in table 2 below.
TABLE 2
| Comparative examples 1 to 1 | Comparative examples 1 to 2 | Comparative examples 1 to 3 | Comparative examples 1 to 4 | |
| SOD / U· g-1 | 356 | 296 | 361 | 401 |
| Comparative example 2-1 | Comparative examples 2 to 2 | |||
| SOD / U· g-1 | 431 | 440 |
Finally, it is also noted that the above-mentioned lists merely illustrate a few specific embodiments of the invention. It is obvious that the invention is not limited to the above embodiments, but that many variations are possible. All modifications which can be derived or suggested by a person skilled in the art from the disclosure of the present invention are to be considered within the scope of the invention.
Claims (3)
1. An antioxidant and anti-aging soft capsule is characterized in that: the content of the soft capsule consists of the following components in parts by weight: 40-58 parts of hemp seed oil, 24-32 parts of snake oil, 8-12 parts of vitamins and 10-17 parts of nutritional ingredients;
the vitamin is at least one of vitamin A, vitamin C, vitamin D and vitamin E;
the nutrient components consist of calcium, magnesium, zinc and iron;
the calcium is calcium carbonate, the magnesium is magnesium sulfate, the zinc is zinc citrate, and the iron is ferrous sulfate.
2. The antioxidant, anti-aging soft capsule of claim 1, wherein: the vitamins comprise 1.0-1.8 parts of vitamin A, 0.4-1.0 part of vitamin C, 0.6-1.2 parts of vitamin D and 6-8 parts of vitamin E.
3. The antioxidant, anti-aging soft capsule of claim 2, wherein: the nutrient components comprise 3-5 parts of calcium carbonate, 4-6 parts of magnesium sulfate, 1-2 parts of zinc citrate and 2-4 parts of ferrous sulfate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910787451.7A CN110638866B (en) | 2019-08-26 | 2019-08-26 | Antioxidant and anti-aging soft capsule |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910787451.7A CN110638866B (en) | 2019-08-26 | 2019-08-26 | Antioxidant and anti-aging soft capsule |
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| CN110638866B true CN110638866B (en) | 2021-07-02 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1861099A (en) * | 2005-05-11 | 2006-11-15 | 王春海 | Snake oil soft capsule |
| CN101965971A (en) * | 2010-07-26 | 2011-02-09 | 广西润达制药股份有限公司 | Walnut hemp oil health food |
| CN108077929A (en) * | 2018-01-15 | 2018-05-29 | 南宁富莱欣生物科技有限公司 | A kind of compound fructus cannabis oil oxidation resisting soft capsule and its production method |
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2019
- 2019-08-26 CN CN201910787451.7A patent/CN110638866B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1861099A (en) * | 2005-05-11 | 2006-11-15 | 王春海 | Snake oil soft capsule |
| CN101965971A (en) * | 2010-07-26 | 2011-02-09 | 广西润达制药股份有限公司 | Walnut hemp oil health food |
| CN108077929A (en) * | 2018-01-15 | 2018-05-29 | 南宁富莱欣生物科技有限公司 | A kind of compound fructus cannabis oil oxidation resisting soft capsule and its production method |
Non-Patent Citations (1)
| Title |
|---|
| 巴马火麻仁油、蛋白粉和木脂素酰胺类提取物对老年小鼠的抗衰老作用研究;蔡霈等;《中南药学》;20100331;第8卷(第03期);第165-170页 * |
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