CN110604793A

CN110604793A - Traditional Chinese veterinary medicine composition for treating African swine fever

Info

Publication number: CN110604793A
Application number: CN201910519706.1A
Authority: CN
Inventors: 刘华西; 付森; 王利; 刘鑫
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-06-17
Filing date: 2019-06-17
Publication date: 2019-12-24

Abstract

The invention discloses a traditional Chinese veterinary medicine composition for treating African swine fever, which belongs to the field of traditional Chinese veterinary medicines and is prepared from the following raw materials in parts by weight: 15-19 parts of pseudo-ginseng, 10-12 parts of ginseng leaf, 8-12 parts of acanthopanax, 9-12 parts of gynostemma pentaphylla, 6-8 parts of cortex lycii radicis, 10-12 parts of cogongrass rhizome, 9-11 parts of radix pseudostellariae, 8-12 parts of barbed skullcap herb, 8-10 parts of barberry root, 6-9 parts of tree peony bark, 6-10 parts of spearmint, 6-8 parts of saffron crocus and 8-10 parts of liquorice. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, cooling blood and stopping bleeding, removing blood stasis and reducing swelling, guiding qi downward and strengthening body resistance, regulating liver and spleen and the like, has the characteristics of quick and good curative effect, and is suitable for treating various African swine fever.

Description

Traditional Chinese veterinary medicine composition for treating African swine fever

Technical Field

The invention belongs to the field of traditional Chinese veterinary medicines, relates to a traditional Chinese veterinary medicine composition, and particularly relates to a traditional Chinese veterinary medicine composition for treating African swine fever.

Background

African swine fever: african Swine Fever (ASF) is an acute, hemorrhagic and virulent infectious disease caused by African Swine Fever Virus (ASFV) infecting domestic pigs and various wild pigs (such as African wild pigs, European wild pigs and the like). The world animal health Organization (OIE) classifies the animal epidemic disease as a legal report animal epidemic disease, and the disease is also a type of animal epidemic disease which is mainly prevented in China. The acute cough-relieving and acute infection has the characteristics of short disease process, high mortality rate of the most acute and acute infections up to 100%, fever (up to 40-42 ℃) as clinical manifestations, accelerated heartbeat, dyspnea, partial cough, serous or mucoid purulent secretion of eyes and nose, cyanosis of skin and obvious bleeding of lymph nodes, kidney and gastrointestinal mucosa.

At present, the treatment of the African swine fever is a weak link, effective preparations and means are lacked, and new safe and effective medicines with quick response are developed and are especially important for controlling the current African swine fever epidemic situation.

Disclosure of Invention

The invention aims to provide a traditional Chinese veterinary medicine composition for treating African swine fever, which has the advantages of quick curative effect, good effect, capability of enhancing the immunity and disease resistance of pigs, greenness and no pollution.

In order to solve the technical problems, the invention adopts the following technical scheme:

a traditional Chinese veterinary medicine composition for treating African swine fever comprises the following raw material medicines in parts by weight: 15-19 parts of pseudo-ginseng, 10-12 parts of ginseng leaf, 8-12 parts of acanthopanax, 9-12 parts of gynostemma pentaphylla, 6-8 parts of cortex lycii radicis, 10-12 parts of cogongrass rhizome, 9-11 parts of radix pseudostellariae, 8-12 parts of barbed skullcap herb, 8-10 parts of barberry root, 6-9 parts of tree peony bark, 6-10 parts of spearmint, 6-8 parts of saffron crocus and 8-10 parts of liquorice.

The optimized technical scheme is that the material is prepared from the following raw materials in parts by weight: 15 parts of pseudo-ginseng, 12 parts of ginseng leaf, 9 parts of acanthopanax, 11 parts of gynostemma pentaphylla, 8 parts of cortex lycii radicis, 10 parts of cogongrass rhizome, 11 parts of radix pseudostellariae, 9 parts of barbed skullcap herb, 8 parts of barberry root, 6 parts of moutan bark, 7 parts of spearmint, 6 parts of saffron and 8 parts of liquorice.

The second optimized technical scheme is that the material is prepared from the following raw materials in parts by weight: 17 parts of pseudo-ginseng, 10 parts of ginseng leaf, 8 parts of acanthopanax, 9 parts of gynostemma pentaphylla, 9 parts of cortex lycii radicis, 12 parts of cogongrass rhizome, 9 parts of radix pseudostellariae, 11 parts of barbed skullcap herb, 9 parts of root of Chinese barberry, 6 parts of moutan bark, 9 parts of spearmint, 8 parts of saffron crocus and 9 parts of liquorice.

The optimized technical scheme is that the material is prepared from the following raw materials in parts by weight: 19 parts of pseudo-ginseng, 10 parts of ginseng leaf, 12 parts of acanthopanax, 10 parts of gynostemma pentaphylla, 8 parts of cortex lycii radicis, 10 parts of cogongrass rhizome, 9 parts of radix pseudostellariae, 12 parts of barbed skullcap herb, 10 parts of root of Chinese barberry, 7 parts of moutan bark, 10 parts of spearmint, 7 parts of saffron and 9 parts of liquorice.

Generally, the veterinary herbal composition for treating swine fever according to the present invention is generally prepared as a powder, and is prepared by the following method: processing the above raw materials in sequence, cleaning, drying, pulverizing, sieving (six or seven sieves), mixing, sterilizing, weighing, and fine packaging.

The traditional Chinese veterinary medicine composition for treating African swine fever can also be prepared into oral liquid, granule, electuary or extract or other forms.

African swine fever is also caused by the invasion of toxic pestilence into the body, and is mainly characterized by high fever, cyanosis of the skin, severe bleeding of the mouth, nose, lymph nodes, internal organs and the like, so clinical treatment mainly comprises clearing away heat and toxic materials, cooling blood and stopping bleeding, removing stasis and reducing swelling, and auxiliary treatment methods of strengthening body resistance and eliminating evil, promoting diuresis and relieving restlessness, tonifying qi and enriching blood, nourishing yin and promoting the production of body fluid, tonifying spleen and stomach, purging fire and relaxing bowels and the like.

The traditional Chinese veterinary medicine composition comprises the following medicinal materials:

in the composition: notoginseng radix, herba Scutellariae Barbatae and cortex moutan as principal drugs,

pseudo-ginseng: sweet, warm and slightly bitter in nature and flavor, entering liver and stomach meridians and entering heart and large intestine. Has the functions of eliminating blood stasis, stopping bleeding, eliminating swelling and relieving pain. Can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, metrostaxis, and swelling and pain due to traumatic injury. Compendium of materia Medica cloud: the medicine has warm, sweet and slightly bitter smell, is a medicine for treating blood system of yangming and jueyin, so that the medicine can treat all kinds of blood diseases;

barbed skullcap herb: pungent, bitter and cold. It enters lung, liver and kidney meridians. Has the effects of clearing away heat and toxic materials, removing blood stasis, and promoting urination. It is mainly used for treating furuncle, swelling and pain of throat, edema, and jaundice. It has the functions of clearing away heat and toxic material, eliminating blood stasis, stopping bleeding and relieving pain. So it can be used for treating hematemesis, epistaxis, stranguria with blood, dysentery, jaundice, sore throat, lung abscess, furuncle, scrofula, and sore.

Moutan bark: bitter and pungent in flavor and slightly cold in nature. It enters heart, liver and kidney meridians. Has the functions of clearing heat, cooling blood, promoting blood circulation and removing blood stasis. It is commonly used for treating warm-toxicity, macula, hematemesis, epistaxis, night fever, morning cold, no sweating, bone steaming, carbuncle, swelling, sore, traumatic injury, etc. The cortex moutan is taken in the formula to improve blood heat and activate blood, so that the cortex moutan has the effects of cooling blood and dissipating blood stasis, and can ensure that blood is smooth without blood stasis, and blood heat is clear without bleeding, and the rhizoma imperatae is added for assisting, so that the cortex moutan is used for cooling blood and stopping bleeding of swine fever in Africa, and the symptoms of heat entering nutrient blood, high fever, deep-red tongue, body macula, bleeding due to blood heat, hematemesis, epistaxis, hematuria, serious heat and fluid impairment and the like of African swine fever.

The traditional Chinese veterinary medicine composition containing ginseng leaves, radix pseudostellariae, acanthopanax, gynostemma pentaphylla, cortex lycii radicis and radix berberidis is used as a ministerial medicine and is used for strengthening body resistance and eliminating evil, promoting diuresis and relieving restlessness, tonifying qi and enriching blood, nourishing yin and promoting fluid production, or assisting monarch medicines to improve the effects of clearing heat and removing toxicity, cooling blood and stopping bleeding. Ginseng leaf is bitter, sweet and cold in nature. It enters lung and stomach meridians. Has the functions of tonifying qi, benefiting lung, dispelling summer heat and promoting the production of body fluid, and is reported in the book of classic: tonify five zang organs, calm spirit, stop palpitation and remove pathogenic qi. Pearl sacs: nourish blood, tonify stomach qi, purge heart fire. Compendium (compendium): it can be used for treating deficiency syndrome, fever, spontaneous perspiration, vertigo, headache, regurgitation, emesis, malaria, chronic dysentery, frequent micturition, stranguria, overstrain, internal injury, apoplexy, heatstroke, flaccidity, arthralgia, hematemesis, hemoptysis, hemophilia, metrorrhagia, and prenatal and postnatal diseases. The formula has the effects of tonifying qi, promoting the secretion of saliva or body fluid, nourishing blood, purging heart fire, and treating the hematemesis, the cough and the hematochezia of the African swine fever.

Acanthopanax root: warm in nature, pungent and slightly bitter in flavor. It enters spleen, kidney and heart meridians. Is also a qi tonifying medicine for tonifying qi, strengthening spleen, tonifying kidney and soothing nerves. Modern pharmacological research considers that: radix Acanthopanacis Senticosi has tranquilizing effect, and can improve brain excitation and inhibit cardiovascular system; can resist tumor; has adaptogen effect and immunoregulation effect. The health-care product has the effects of resisting fatigue, anoxia, high and low temperature, radiation and stress, delaying aging, enhancing immune function, resisting inflammation, inhibiting platelet aggregation, regulating endocrine dysfunction, slowing heart rate, reducing myocardial oxygen consumption and myocardial oxygen consumption index, reducing myocardial oxygen utilization rate, protecting myocardial ischemia, enhancing metabolism and promoting tissue regeneration, resisting bacteria and viruses, detoxifying and the like, thereby improving the immune function of an individual with diseases, and improving the tolerance rate and the cure rate.

Gynostemma pentaphylla: sweet, bitter and cold in nature. Entering the lung; a spleen; the kidney channel. It has the functions of benefiting qi, invigorating spleen, eliminating phlegm, relieving cough, clearing away heat and toxic material. It is not only a deficiency-tonifying drug, phlegm-resolving drug, but also a heat-clearing drug. The composition is used for increasing the effects of tonifying qi and spleen of the ginseng leaves, and is matched with the heat clearing effect of the moutan bark.

Cortex lycii radicis: sweet and cold in nature, it enters lung, liver and kidney meridians. Cool blood and remove heat, clear lung-heat and descend fire. It is commonly used for tidal fever due to yin deficiency, night sweat due to bone steaming, cough due to lung heat, hemoptysis, epistaxis, internal heat and diabetes. It can clear lung heat, clear and purify lung qi, and relieve cough and asthma, and can be used with lalang grass rhizome for treating hematemesis and epistaxis, and clearing heat and cooling blood. Daily herbal medicine: treating upper diaphragm hematemesis; the text of materia Medica: it is indicated for fever due to consumptive disease, alternating cold and heat, all with blood syndromes. Therefore, the recipe is selected to tonify kidney yin, clear deficiency heat, stop bleeding and cool blood.

Root of Chinese barberry: it is cold in nature and slightly bitter in taste, and has the actions of clearing heat, promoting diuresis and dissipating blood stasis. Can be used for treating dysentery with bloody stool and jaundice. In the Chiense on Sichuan Chinese herbs (Yan Zhi): the Chinese medicinal composition has the effects of clearing away heat and toxic materials, diminishing inflammation and resisting bacteria. It is indicated for blood-shot eyes, red dysentery, hematemesis, overstrain, swollen and sore throat, diarrhea, and toothache. Guizhou herbal medicine: "antipyretic, diuresis, stasis-resolving, pain-relieving, blood-cooling. The prescription is used for improving and enhancing the functions of the monarch drug of clearing heat and removing toxicity, cooling blood and stopping bleeding.

Cogongrass rhizome: radix pseudostellariae is used as adjuvant, and rhizoma imperatae is sweet and cold and enters lung, stomach, small intestine and bladder channels. Cool blood to stop bleeding, it can cool blood, stop bleeding, clear heat and induce diuresis. It is indicated for feverish sensation with polydipsia, hematemesis, epistaxis, stomach heat and hiccup, gonorrhea, edema and jaundice.

Radix pseudostellariae: sweet, slightly bitter and neutral. It enters spleen and lung meridians. Moistening body, invigorating qi, and promoting salivation; replenishing qi to invigorate the spleen, promoting the production of body fluid and moistening the lung, and is used for treating spleen deficiency and tiredness, inappetence, weakness after illness and deficiency of qi and yin. Is used for improving the functions of the spleen and the stomach of the sick pigs and strengthening the qi of the spleen and the stomach.

Small safflower: is whole plant of Vermilion (Labiatae), collected in summer and autumn. Cut off and dried in the sun, pungent, astringent and slightly bitter, and cool. Has the effects of cooling blood, stopping bleeding, clearing heat and promoting diuresis. Can be used for treating metrorrhagia, hyperpyrexia, abdominal pain, etc.

Spearmint: whole grass (spearmint): pungent and sweet with mild temperature. Dispel wind and cold, relieve cough, resolve swelling and remove toxicity. Can be used for treating common cold, cough, gastralgia, abdominal distention, and nervous headache; it is externally used for treating traumatic swelling and pain, conjunctival congestion and red pain.

Licorice root: is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Leguminosae, is sweet and neutral, and has effects of invigorating spleen and qi, clearing heat and detoxicating, and harmonizing the effects of the other drugs.

Modern pharmacological research shows that the effective components of the veterinary medicine composition can promote the production of interleukin 2, prevent NDA canceration, promote the production of monocyte macrophage secretion, phagocytize virus and kill pathogenic microorganism. Promote the differentiation and proliferation of T lymphocytes and generate killer T lymphocytes. Proliferate and generate killer T lymphocytes. Can increase the production of lymphokines, enhance the activity of macrophages and the function of natural killer cells, improve the action of interferon, and completely reverse the immune mechanism disorder caused by viruses.

The invention has the beneficial effects that: the composition for preventing and treating African swine fever belongs to a natural pure Chinese herbal medicine preparation, has strong antibacterial and antiviral effects on African swine fever viruses, has the functions of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain, cooling blood and stopping bleeding, promoting the production of body fluid to quench thirst, tonifying qi and generating blood, tonifying spleen and stomach, warming toxic and developing spots, purging intense heat and relaxing bowels, strengthening body resistance and eliminating evil, promoting diuresis and relieving restlessness, washing intestines and clearing hollow viscera, regulating liver, spleen and kidney and the like, can better give consideration to both principal symptoms and concurrent symptoms, and obtains exact curative effect in a large number of practical tests.

The invention is used for treating African swine fever, achieves better effect, and the case statistics are shown in the following table:

african swine fever treatment statistical table (time: 10 months in 2018-4 months in 2019)

Item	Total treatment number	Number of cure cases	Effective number of cases	Number of invalid cases	Effective rate (%)
						Acute/subacute African swine fever	1533	1076	372	85	94.46
Chronic African swine fever	1229	1039	123	67	94.55
						Total up to	2762	2315	295	152	94.50

The above statistics are mainly based on the following:

(one) determination of statistical cases:

the first diagnosis can be made according to epidemiology, clinical symptoms and pathological changes, and then the cases except the non-Zhou swine fever can be excluded by a laboratory diagnosis means (adopting immunofluorescence technology). The method comprises the following specific steps:

A. acute type

Subcutaneous bleeding in sick pigs, excess body fluid present in the heart (pericardial hydrops with yellowish fluid) and body cavities (edema, ascites), bleeding spots on the heart surface (epicardium), bladder and kidneys (cortex and renal pelvis), possibly engorgement and stasis spots in the lungs; there is foam in the trachea and bronchi, severe alveolar and interstitial pulmonary edema; ecchymosis, ecchymosis (major bleeding), excessive clotting in the stomach, small intestine and large intestine; hepatic congestion and gallbladder hemorrhage; lymph node (especially gastrointestinal and renal) enlargement, edema, and whole lymph node bleeding, with a morphology similar to a blood clot; the spleen is enlarged and embrittled, and the round edge becomes dark red or even black; and a spot on the kidney capsule (spotting).

B subacute type

The main clinical manifestations are: subacute african swine fever is caused by moderately virulent strains and may occur in endemic regions. The clinical symptoms are similar to those observed in the acute form, except for the more pronounced vasculopathy, mainly bleeding and edema. Fever of different degrees is common, accompanied by indigestion and loss of appetite; pain may occur while walking and joints often swell due to fluid accumulation and fibrosis. There may be signs of dyspnea and pneumonia; pregnant sows may be aborted and serous pericarditis (fluid filling around the heart) often progresses to more severe cellulosic, sexual pericarditis.

C. Slow type

The clinical symptoms of the main table are: the clinical symptoms are mild fever starting 14 to 21 days after infection with mild dyspnea and moderate to severe joint swelling. Erythema, bulging, and necrosis of the skin also commonly occur. Autopsy showed pneumonia with caseous necrosis (sometimes with localized calcification) in the lungs, fibrous pericarditis; and enlargement of lymph nodes (mainly mediastinal lymph nodes) and regional bleeding.

Laboratory diagnostics

On the basis of the primary diagnosis, the fluorescence quantitative PCR examination is adopted for confirmation.

(II) evaluating the curative effect:

and (3) curing: the symptoms completely disappear, and the main physical and chemical inspection indexes are normal;

the method has the following advantages: all aspects of symptoms are improved compared with before treatment;

and (4) invalidation: compared with the prior treatment, all symptoms are not obviously improved.

Effective rate (number of cure cases + number of effective cases)/total number of treatment cases.

Detailed Description

The present invention will be further described with reference to the following examples. The following description is given by way of example and in the form of a powder, without limiting the scope of the invention.

Example one

15g of pseudo-ginseng, 12g of ginseng leaves, 9g of acanthopanax, 11g of gynostemma pentaphylla, 8g of cortex lycii radicis, 10g of cogongrass rhizome, 11g of radix pseudostellariae, 9g of sculellaria barbata, 8g of barberry root, 6g of moutan bark, 7g of spearmint, 6g of saffron crocus and 8g of liquorice which are not damaged by worms or rotten are respectively taken for later use.

Can be increased in proportion to the veterinary composition according to the required amount of the veterinary composition.

Cleaning the above materials, drying, pulverizing, sieving (seven sieve), mixing, sterilizing, and packaging according to 50g per bag.

The using method comprises the following steps: the medicine is taken according to the dosage of 150g for about 25kg of piglets per day, the dosage of each kg of body weight of other sick pigs is 6g, and the pigs are fed for three times in the morning, in the middle and in the evening.

When the veterinary drug composition is fed, for sick pigs with remarkably reduced appetite and even dead eating, the veterinary drug composition is added into a certain amount of concentrated feed, is uniformly stirred, is kept at a moderate temperature (no cold or no hot), and is then drenched. For sick pigs with better appetite, the traditional Chinese veterinary medicine composition can be mixed in complete formula feed for the sick pigs to eat. Three days is a course of treatment, and generally, the patients can be cured after being fed for 1-2 courses of treatment. In the treatment process, sick pigs need to be isolated and treated independently, and uninfected pigs can also be prevented by using the medicine.

This example is suitable for the treatment of chronic African swine fever with mild epidemic.

Example two

17g of pseudo-ginseng, 10g of ginseng leaves, 8g of acanthopanax, 9g of gynostemma pentaphylla, 9g of cortex lycii radicis, 12g of cogongrass rhizome, 9g of radix pseudostellariae, 11g of sculellaria barbata, 9g of barberry root, 6g of moutan bark, 9g of spearmint, 8g of saffron crocus and 9g of liquorice which are not damaged by worms or rotten moulds are respectively taken for later use.

When the veterinary drug composition is fed, for sick pigs with remarkably reduced appetite and even dead eating, the veterinary drug composition is added into a certain amount of concentrated feed, is uniformly stirred, is kept at a moderate temperature (no cold or no hot), and is then drenched. Three days is a course of treatment, and the patient can be cured by feeding the medicine for 2 courses generally. In the treatment process, sick pigs need to be isolated and treated independently, and uninfected pigs can also be prevented by using the medicine.

This example is applicable to the treatment of moderate epidemic african swine fever or sub-acute african swine fever.

EXAMPLE III

19g of pseudo-ginseng, 10g of ginseng leaf, 12g of acanthopanax, 10g of gynostemma pentaphylla, 8g of cortex lycii radicis, 10g of cogongrass rhizome, 9g of radix pseudostellariae, 12g of sculellaria barbata, 10g of barberry root, 7g of moutan bark, 10g of spearmint, 7g of saffron crocus and 9g of liquorice which are not damaged by worms or rotten moulds are respectively taken for later use.

When the veterinary drug composition is fed, for sick pigs with remarkably reduced appetite and even dead eating, the veterinary drug composition is added into a certain amount of concentrated feed, is uniformly stirred, is kept at a moderate temperature (no cold or no hot), and is then drenched. Three days is a course of treatment, and the patient can be cured after 2 courses of treatment generally. In the treatment process, sick pigs need to be isolated and treated independently, and uninfected pigs can also be prevented by using the medicine.

This example is suitable for the treatment of severe epidemic african swine fever or acute african swine fever.

The above detailed description of the veterinary drug composition for treating African swine fever with reference to the examples is illustrative and not restrictive, and several examples may be cited within the limits thereof, so that variations and modifications without departing from the general concept of the present invention shall fall within the scope of the present invention.

Claims

1. A traditional Chinese veterinary medicine composition for treating African swine fever is characterized by being prepared from the following raw materials in parts by weight: 15-19 parts of pseudo-ginseng, 10-12 parts of ginseng leaf, 8-12 parts of acanthopanax, 9-12 parts of gynostemma pentaphylla, 6-8 parts of cortex lycii radicis, 10-12 parts of cogongrass rhizome, 9-11 parts of radix pseudostellariae, 8-12 parts of barbed skullcap herb, 8-10 parts of barberry root, 6-9 parts of tree peony bark, 6-10 parts of spearmint, 6-8 parts of saffron crocus and 8-10 parts of liquorice.

2. The veterinary drug composition for treating non-Zhou swine fever according to claim 1, is prepared from the following raw materials in parts by weight: 15 parts of pseudo-ginseng, 12 parts of ginseng leaf, 9 parts of acanthopanax, 11 parts of gynostemma pentaphylla, 8 parts of cortex lycii radicis, 10 parts of cogongrass rhizome, 11 parts of radix pseudostellariae, 9 parts of barbed skullcap herb, 8 parts of barberry root, 6 parts of moutan bark, 7 parts of spearmint, 6 parts of saffron and 8 parts of liquorice.

3. The veterinary drug composition for treating non-Zhou swine fever according to claim 1, is prepared from the following raw materials in parts by weight: 17 parts of pseudo-ginseng, 10 parts of ginseng leaf, 8 parts of acanthopanax, 9 parts of gynostemma pentaphylla, 9 parts of cortex lycii radicis, 12 parts of cogongrass rhizome, 9 parts of radix pseudostellariae, 11 parts of barbed skullcap herb, 9 parts of root of Chinese barberry, 6 parts of moutan bark, 9 parts of spearmint, 8 parts of saffron crocus and 9 parts of liquorice.

4. The veterinary drug composition for treating non-Zhou swine fever according to claim 1, is prepared from the following raw materials in parts by weight: 19 parts of pseudo-ginseng, 10 parts of ginseng leaf, 12 parts of acanthopanax, 10 parts of gynostemma pentaphylla, 8 parts of cortex lycii radicis, 10 parts of cogongrass rhizome, 9 parts of radix pseudostellariae, 12 parts of barbed skullcap herb, 10 parts of root of Chinese barberry, 7 parts of moutan bark, 10 parts of spearmint, 7 parts of saffron and 9 parts of liquorice.