CN105748560A - Combinatorial compounded medicine for treating high swine fever - Google Patents
Combinatorial compounded medicine for treating high swine fever Download PDFInfo
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- 238000002360 preparation method Methods 0.000 claims abstract description 39
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims abstract description 22
- 229960003957 dexamethasone Drugs 0.000 claims abstract description 22
- 229960001931 ampicillin sodium Drugs 0.000 claims abstract description 18
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- 239000002994 raw material Substances 0.000 claims abstract description 11
- 208000001647 Renal Insufficiency Diseases 0.000 claims abstract description 9
- 201000006370 kidney failure Diseases 0.000 claims abstract description 9
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
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- 229960000223 tilmicosin Drugs 0.000 description 1
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a combinatorial compounded medicine for treating high swine fever. The combinatorial compounded medicine is prepared from the following raw materials: a heat-clearing and pain-stopping medicine, ampicillin sodium, dexamethasone, a traditional Chinese medicine preparation and a renal failure preventing medicine, wherein the mass ratio of the heat-clearing and pain-stopping medicine to dexamethasone is (1000-3000):(4-12); the mass ratio of ampicillin sodium to the traditional Chinese medicine preparation to the renal failure preventing medicine is (10-20):(50-100):(0.5-1.5). The combinatorial compounded medicine has a very good treatment effect on high swine fever caused by virus and bacterial infection except swine fever and African swine fever, generally the disease can be treated within 2-3 days and does not reoccur easily, abuse of antibiotics is reduced, influence of medicinal residues on human bodies can be reduced, environmental pollution can be reduced, and very high popularization values can be made.
Description
Technical field
The present invention relates to field of veterinary, be specifically related to a kind of compound combination medicine treating porcine hyperthermia
Thing.
Background technology
Porcine hyperthermia is to be mixed by the viruses such as high-pathogenicity blue ear disease and many cause of diseases such as bacterium, parasite
It is acute, hot that conjunction or scabies secondary infection cause, the highly pathogenic and communicable disease of lethal.
Porcine hyperthermia is the disease that a kind of M & M is the highest, occurs mainly in finishing period pig
With part sow, sick pig clinic mainly shows as early stage body temperature and is up to 41～43 DEG C, spirit
Depressed, jumpbogroup performance apocleisis, rubefaction, there are erythema, muscle tremors, eye under four limbs and abdomen
Conjunctiva flush, having tear spot, discharge of eye to increase, asoscope is dried, serosity secretion is flowed out in nostril
Thing, the asthma of part pig, has difficulty in breathing into serious abdominal respiration, oliguria and yellow, ight soil is stiff,
Color is black.Indivedual pigs occur that four limbs are struck the nervous symptoms of sample, and whole body is septicemia change.Sick
The fur that journey is slightly grown is unglazed, and happiness is sleeping, and whole body is pale, shakiness of walking, and finally dies of exhaustion.Have
Cornea xanthochromia, the initial stage uses antipyretic and antibiosis to have certain curative effect.Symptom has been delayed
Solving, but recur after drug withdrawal, body temperature quickly rises, and dies from septicaemia.The appearance miscarriage of susceptible sow,
Stillborn foetus and weak young phenomenon.
For preventing and treating porcine hyperthermia, many employing some antibiotic preventing and treatings and injection Chinese medicine system clinically
Agent.But, western medicine antibiotics the first pin can be brought down a fever, but can not effect a radical cure porcine hyperthermia, also
Bounce-back being produced, can not bring down a fever even if having an injection again.And the existing Chinese medicine length course for the treatment of, take effect slow,
Cure rate is low.
Summary of the invention
It is an object of the invention to provide a kind of compound composite medicament treating porcine hyperthermia, take effect
Hurry up, cure rate is high, and does not recurs.
For realizing object above, the present invention is achieved by the following technical programs:
A kind of compound composite medicament treating porcine hyperthermia, is made up of following raw material: antipyretic analgesic medicine,
Ampicillin sodium, dexamethasone, Chinese medicine preparation, prevention kidney failure medicine, wherein antipyretic analgesic medicine
It is 1000-3000:4-12 with the mass ratio of dexamethasone, ampicillin sodium, Chinese medicine preparation, pre-
The mass ratio of anti-kidney failure medicine is 10-20:50-100:0.5-1.5.
Preferably, described antipyretic analgesic medicine is analgin injection, aminopyrine parenteral solution and peace pain
Determine the one in parenteral solution.
Preferably, described prevention kidney failure medicine is frusemide.
Preferably, the raw material of described Chinese medicine preparation includes Radix Isatidis, honeysuckle, scutelloside, buffalo
Angle.
Preferably, the preparation method of described Chinese medicine preparation is by Radix Isatidis, honeysuckle, scutelloside,
Cornu bubali weighs according to 2:3:1:4 ratio, after adding 3 times of water soaking 2h of quality of medicinal material, adds water
Obtain after decocting 3h.
The using method of the compound composite medicament for the treatment of porcine hyperthermia: by antipyretic analgesic medicine, ammonia benzyl west
Woods sodium, dexamethasone and prevention kidney failure medicine mixing side intramuscular injection, Chinese medicine preparation opposite side intramuscular injection.
The method have the benefit that and the invention provides a kind of medicine treating porcine hyperthermia, for
Body temperature, more than 38.5 DEG C, is infected by the virus in addition to swine fever and African swine fever and bacterium and causes
Hyperpyrexia disease have good curative effect, within general 2-3 days, disease pig can be fully recovered, and be difficult to recurrence, effectively
Rate relatively traditional therapy can improve nearly 40%, decreases the economic loss of raiser, the present invention
Also reduce the abuse of antibiotic, reduce the medicament residue impact on people, reduce environmental pollution,
There is good promotional value.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below will knot
Close the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely retouched
State, it is clear that described embodiment is a part of embodiment of the present invention rather than whole realities
Execute example.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creation
The every other embodiment obtained under property work premise, broadly falls into the scope of protection of the invention.
Embodiment 1:
A kind of compound composite medicament treating porcine hyperthermia, is made up of following raw material: analgin is injected
Liquid, ampicillin sodium, dexamethasone, Chinese medicine preparation, frusemide, wherein analgin injection
It is 2000:8 with the mass ratio of dexamethasone, ampicillin sodium, Chinese medicine preparation, the matter of frusemide
Amount ratio is 15:80:1.Wherein the preparation method of Chinese medicine preparation is by Radix Isatidis, honeysuckle, yellow
A kind of reed mentioned in ancient books glycosides, cornu bubali weigh according to 2:3:1:4 ratio, add 3 times of water soaking 2h of quality of medicinal material
After, obtain after boiling 3h.
Embodiment 2:
A kind of compound composite medicament treating porcine hyperthermia, is made up of following raw material: aminopyrine is noted
Penetrate liquid, ampicillin sodium, dexamethasone, Chinese medicine preparation, frusemide, wherein aminopyrine note
The mass ratio penetrating liquid and dexamethasone is 1000:4, ampicillin sodium, Chinese medicine preparation, frusemide
Mass ratio be 20:100:0.5.Wherein the preparation method of Chinese medicine preparation is by Radix Isatidis, gold
Honeysuckle flower, scutelloside, cornu bubali weigh according to 2:3:1:4 ratio, add 3 times of water of quality of medicinal material
After soaking 2h, obtain after boiling 3h.
Embodiment 3:
A kind of compound composite medicament treating porcine hyperthermia, is made up of following raw material: antondin is injected
Liquid, ampicillin sodium, dexamethasone, Chinese medicine preparation, frusemide, wherein Components In Antongding Injectate
It is 3000:12 with the mass ratio of dexamethasone, ampicillin sodium, Chinese medicine preparation, frusemide
Mass ratio is 20:50:1.5.Wherein the preparation method of Chinese medicine preparation is by Radix Isatidis, honeysuckle,
Scutelloside, cornu bubali weigh according to 2:3:1:4 ratio, add 3 times of water soaking 2h of quality of medicinal material
After, obtain after boiling 3h.
Embodiment 4:
A kind of compound composite medicament treating porcine hyperthermia, is made up of following raw material: aminopyrine is noted
Penetrate liquid, ampicillin sodium, dexamethasone, Chinese medicine preparation, frusemide, wherein aminopyrine note
The mass ratio penetrating liquid and dexamethasone is 1500:10, ampicillin sodium, Chinese medicine preparation, furan plug
The mass ratio of rice is 15:60:0.8.Wherein the preparation method of Chinese medicine preparation is by Radix Isatidis, gold
Honeysuckle flower, scutelloside, cornu bubali weigh according to 2:3:1:4 ratio, add 3 times of water of quality of medicinal material
After soaking 2h, obtain after boiling 3h.
Embodiment 5:
A kind of compound composite medicament treating porcine hyperthermia, is made up of following raw material: analgin is injected
Liquid, ampicillin sodium, dexamethasone, Chinese medicine preparation, frusemide, wherein analgin injection
It is 2500:9 with the mass ratio of dexamethasone, ampicillin sodium, Chinese medicine preparation, the matter of frusemide
Amount ratio is 18:80:1.2.Wherein the preparation method of Chinese medicine preparation is by Radix Isatidis, honeysuckle,
Scutelloside, cornu bubali weigh according to 2:3:1:4 ratio, add 3 times of water soaking 2h of quality of medicinal material
After, obtain after boiling 3h.
Embodiment 6:
A kind of compound composite medicament treating porcine hyperthermia, is made up of following raw material: antondin is injected
Liquid, ampicillin sodium, dexamethasone, Chinese medicine preparation, frusemide, wherein Components In Antongding Injectate
It is 2000:10 with the mass ratio of dexamethasone, ampicillin sodium, Chinese medicine preparation, frusemide
Mass ratio is 12:70:1.3.Wherein the preparation method of Chinese medicine preparation is by Radix Isatidis, honeysuckle,
Scutelloside, cornu bubali weigh according to 2:3:1:4 ratio, add 3 times of water soaking 2h of quality of medicinal material
After, obtain after boiling 3h.
Clinical case: select 200 examples to suffer from by the virus in addition to swine fever and African swine fever with thin
Bacterium infects the sick pig of the hyperpyrexia disease caused, and clinical manifestation has early stage body temperature to be up to 41-43 DEG C,
Spirit is depressed, and apocleisis is thirsty, and mouth and nose breathe heavily thick gas, astasia, rubefaction, four limbs
There is erythema with under abdomen, be randomly divided into two groups, experimental group and control group, often organize 100 examples, and often
In group, the number of the numerous sow of energy is 30 examples, and two groups there was no significant difference.
Methods for the treatment of: use the medicine of the embodiment of the present invention 1, according to the body weight of sick pig, according to peace
Be nearly parenteral solution 2000mg/ time, ampicillin sodium 15mg/kg body weight, dexamethasone 8mg/ time,
Chinese medicine preparation 80mg/kg body weight, frusemide 1mg/kg body weight, by analgin injection, ammonia
Benzyl XiLin sodium, dexamethasone and frusemide mixing give the side intramuscular injection of disease pig, and Chinese medicine preparation gives
Sick pig opposite side intramuscular injection；Control group uses 2000mg/ analgin injection, 20mg/kg body weight
Tilmicosin, 8mg/ dexamethasone and 3g/kg body weight Radix Isatidis injection side intramuscular injection.Experiment
Group and control group regard disease pig the situation that is in a bad way, 1-2 time on the one drug therapy, 3 days is a treatment
Journey.
Criterion of therapeutical effect:
Cure: the full recoveries such as the sick body temperature of pig, body colour, spirit are normal, and do not recur；
Effective: the sick body temperature of pig, body colour, spirit, appetite progressively recover normal；
Invalid: symptom is not improved, seriously there is death.
Result for the treatment of is shown in Table 1:
The porcine hyperthermia result for the treatment of of table 1 experimental group and control group
As can be seen from Table 1, the curative effect control group to be substantially better than of experimental group, effectively
Rate exceeds control group 39%, and the inefficiency of experimental group is only 5%, this imply that the death rate of disease pig
Low, decrease the economic loss of raiser.
Sow medication result for the treatment of numerous for the energy in experimental group and control group is shown in Table 2.
Table 2 experimental group and the control group result for the treatment of to the numerous sow hyperpyrexia disease of energy
From Table 2, it can be seen that the numerous sow hyperpyrexia disease of energy is had by the present invention well treats effect
Really, it is substantially reduced the death rate of the numerous sow of energy, alleviates the economic loss of raiser.
It can be seen that the present invention has good curative effect for porcine hyperthermia from experimental result,
Efficient up to 95%.
Detection and clinical case through drug effect find, the medicine effect in embodiment 1 is optimal.
It should be noted that in this article, the relational terms of such as first and second or the like is only
Only it is used for separating an entity or operation with another entity or operating space, and not necessarily
Require or imply and there is the relation of any this reality or suitable between these entities or operation
Sequence.And, term " includes ", " comprising " or its any other variant are intended to nonexcludability
Comprise, so that include the process of a series of key element, method, article or equipment not only
Including those key elements, but also include other key elements being not expressly set out, or also include
The key element intrinsic for this process, method, article or equipment.There is no more restriction
In the case of, statement " including ... " key element limited, it is not excluded that including described wanting
Process, method, article or the equipment of element there is also other identical element.
Above example only in order to technical scheme to be described, is not intended to limit；Although
With reference to previous embodiment, the present invention is described in detail, those of ordinary skill in the art
It is understood that the technical scheme described in foregoing embodiments still can be modified by it,
Or wherein portion of techniques feature is carried out equivalent；And these amendments or replacement, not
The essence making appropriate technical solution departs from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (5)
1. the compound composite medicament treating porcine hyperthermia, it is characterised in that by following raw material
Composition: antipyretic analgesic medicine, ampicillin sodium, dexamethasone, Chinese medicine preparation, prevention kidney failure
Medicine, wherein the mass ratio of antipyretic analgesic medicine and dexamethasone is 1000-3000:4-12, ammonia benzyl west
Woods sodium, Chinese medicine preparation, the mass ratio of prevention kidney failure medicine are 10-20:50-100:0.5-1.5.
2. the compound composite medicament treating porcine hyperthermia as claimed in claim 1, its feature exists
In, described antipyretic analgesic medicine is analgin injection, aminopyrine parenteral solution and antondin injection
One in liquid.
3. the compound composite medicament treating porcine hyperthermia as claimed in claim 1, its feature exists
In, described prevention kidney failure medicine is frusemide.
4. the compound composite medicament treating porcine hyperthermia as claimed in claim 1, its feature exists
In, the raw material of described Chinese medicine preparation includes Radix Isatidis, honeysuckle, scutelloside, cornu bubali.
5. the compound composite medicament treating porcine hyperthermia as claimed in claim 4, its feature exists
In, the preparation method of described Chinese medicine preparation is by Radix Isatidis, honeysuckle, scutelloside, cornu bubali
Weigh according to 2:3:1:4 ratio, after adding 3 times of water soaking 2h of quality of medicinal material, boiling
Obtain after 3h.
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| CN110604793A (en) * | 2019-06-17 | 2019-12-24 | 刘华西 | Traditional Chinese veterinary medicine composition for treating African swine fever |
| WO2020252757A1 (en) * | 2019-06-19 | 2020-12-24 | 海南今珠农业发展有限公司 | Pharmaceutical composition for controlling african swine fever, and extraction, injection and use thereof |
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| CN102048749A (en) * | 2009-11-05 | 2011-05-11 | 胡友忠 | Medicament for treating swine high fever |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110604793A (en) * | 2019-06-17 | 2019-12-24 | 刘华西 | Traditional Chinese veterinary medicine composition for treating African swine fever |
| WO2020252757A1 (en) * | 2019-06-19 | 2020-12-24 | 海南今珠农业发展有限公司 | Pharmaceutical composition for controlling african swine fever, and extraction, injection and use thereof |
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Application publication date: 20160713 |