CN110604749A - 动物双歧杆菌及其在控制糖尿病或高血脂症特别是体重增加或肥胖中的应用 - Google Patents
动物双歧杆菌及其在控制糖尿病或高血脂症特别是体重增加或肥胖中的应用 Download PDFInfo
- Publication number
- CN110604749A CN110604749A CN201910818555.XA CN201910818555A CN110604749A CN 110604749 A CN110604749 A CN 110604749A CN 201910818555 A CN201910818555 A CN 201910818555A CN 110604749 A CN110604749 A CN 110604749A
- Authority
- CN
- China
- Prior art keywords
- bifidobacterium animalis
- product
- bifidobacterium
- increasing
- hyperlipidemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001134770 Bifidobacterium animalis Species 0.000 title claims abstract description 104
- 229940118852 bifidobacterium animalis Drugs 0.000 title claims abstract description 104
- 208000031226 Hyperlipidaemia Diseases 0.000 title claims abstract description 17
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 15
- 208000008589 Obesity Diseases 0.000 title claims abstract description 13
- 235000020824 obesity Nutrition 0.000 title claims abstract description 13
- 230000004584 weight gain Effects 0.000 title claims abstract description 11
- 235000019786 weight gain Nutrition 0.000 title claims abstract description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 37
- 239000008103 glucose Substances 0.000 claims abstract description 37
- 230000000694 effects Effects 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 32
- 230000001965 increasing effect Effects 0.000 claims abstract description 30
- 102100024295 Maltase-glucoamylase Human genes 0.000 claims abstract description 27
- 108010028144 alpha-Glucosidases Proteins 0.000 claims abstract description 27
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 23
- 239000002207 metabolite Substances 0.000 claims abstract description 21
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims abstract description 19
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims abstract description 18
- 101800000224 Glucagon-like peptide 1 Proteins 0.000 claims abstract description 18
- 102100040918 Pro-glucagon Human genes 0.000 claims abstract description 18
- 102000016267 Leptin Human genes 0.000 claims abstract description 17
- 108010092277 Leptin Proteins 0.000 claims abstract description 17
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims abstract description 17
- 229940039781 leptin Drugs 0.000 claims abstract description 17
- 230000006377 glucose transport Effects 0.000 claims abstract description 15
- 210000004153 islets of langerhan Anatomy 0.000 claims abstract description 15
- 230000028327 secretion Effects 0.000 claims abstract description 15
- 239000000126 substance Substances 0.000 claims abstract description 15
- 206010022489 Insulin Resistance Diseases 0.000 claims abstract description 12
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 12
- 238000004321 preservation Methods 0.000 claims abstract description 7
- 210000004027 cell Anatomy 0.000 claims description 48
- 230000001580 bacterial effect Effects 0.000 claims description 20
- 235000013305 food Nutrition 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 208000021017 Weight Gain Diseases 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 230000000813 microbial effect Effects 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 3
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 208000029078 coronary artery disease Diseases 0.000 claims description 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 3
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 241000186000 Bifidobacterium Species 0.000 abstract description 14
- 241001465754 Metazoa Species 0.000 abstract description 14
- 238000011161 development Methods 0.000 abstract description 4
- 244000005700 microbiome Species 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 239000000047 product Substances 0.000 description 51
- 241000699670 Mus sp. Species 0.000 description 39
- 239000000243 solution Substances 0.000 description 33
- 241000894006 Bacteria Species 0.000 description 29
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 22
- 239000006228 supernatant Substances 0.000 description 12
- 102000004877 Insulin Human genes 0.000 description 11
- 108090001061 Insulin Proteins 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 235000009200 high fat diet Nutrition 0.000 description 11
- 229940125396 insulin Drugs 0.000 description 11
- 102000051325 Glucagon Human genes 0.000 description 9
- 108060003199 Glucagon Proteins 0.000 description 9
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 9
- 229960004666 glucagon Drugs 0.000 description 9
- 230000005764 inhibitory process Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000001963 growth medium Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 238000011160 research Methods 0.000 description 7
- 239000012488 sample solution Substances 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 230000037396 body weight Effects 0.000 description 6
- 230000000968 intestinal effect Effects 0.000 description 6
- 238000013116 obese mouse model Methods 0.000 description 6
- 239000006041 probiotic Substances 0.000 description 6
- 235000018291 probiotics Nutrition 0.000 description 6
- 230000002441 reversible effect Effects 0.000 description 6
- 210000000813 small intestine Anatomy 0.000 description 6
- 108090001126 Furin Proteins 0.000 description 5
- 108090000544 Proprotein convertase 1 Proteins 0.000 description 5
- 102000004085 Proprotein convertase 1 Human genes 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 5
- 238000012258 culturing Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 238000009630 liquid culture Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 4
- 241000186660 Lactobacillus Species 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 235000014590 basal diet Nutrition 0.000 description 4
- 150000001720 carbohydrates Chemical group 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000000855 fermentation Methods 0.000 description 4
- 230000004151 fermentation Effects 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 229940039696 lactobacillus Drugs 0.000 description 4
- 238000013227 male C57BL/6J mice Methods 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 230000004580 weight loss Effects 0.000 description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 3
- 102000007469 Actins Human genes 0.000 description 3
- 108010085238 Actins Proteins 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000001332 colony forming effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 210000004923 pancreatic tissue Anatomy 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 2
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 229920001202 Inulin Polymers 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- 241001052560 Thallis Species 0.000 description 2
- 229940040526 anhydrous sodium acetate Drugs 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 208000029742 colonic neoplasm Diseases 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229960001305 cysteine hydrochloride Drugs 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
- 229940029339 inulin Drugs 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- ISPYRSDWRDQNSW-UHFFFAOYSA-L manganese(II) sulfate monohydrate Chemical compound O.[Mn+2].[O-]S([O-])(=O)=O ISPYRSDWRDQNSW-UHFFFAOYSA-L 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 210000000110 microvilli Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- IFBHRQDFSNCLOZ-IIRVCBMXSA-N 4-nitrophenyl-α-d-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C([N+]([O-])=O)C=C1 IFBHRQDFSNCLOZ-IIRVCBMXSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 description 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000002705 Glucose Intolerance Diseases 0.000 description 1
- 102000004366 Glucosidases Human genes 0.000 description 1
- 108010056771 Glucosidases Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 101710151387 Serine protease 1 Proteins 0.000 description 1
- 102100032491 Serine protease 1 Human genes 0.000 description 1
- 102000003673 Symporters Human genes 0.000 description 1
- 108090000088 Symporters Proteins 0.000 description 1
- 102000000591 Tight Junction Proteins Human genes 0.000 description 1
- 108010002321 Tight Junction Proteins Proteins 0.000 description 1
- 101710119665 Trypsin-1 Proteins 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000010805 cDNA synthesis kit Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 201000010897 colon adenocarcinoma Diseases 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 235000014048 cultured milk product Nutrition 0.000 description 1
- 235000021316 daily nutritional intake Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000005686 eating Nutrition 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000021107 fermented food Nutrition 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000010855 food raising agent Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000021098 high calorie intake Nutrition 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000003125 immunofluorescent labeling Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 235000021231 nutrient uptake Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000002571 pancreatic alpha cell Anatomy 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 201000009104 prediabetes syndrome Diseases 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/515—Animalis
Abstract
Description
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910818555.XA CN110604749B (zh) | 2019-08-30 | 2019-08-30 | 动物双歧杆菌a12及其在控制糖尿病或高血脂症特别是体重增加或肥胖中的应用 |
NL2026360A NL2026360B1 (en) | 2019-08-30 | 2020-08-27 | Uses of Bifidobacterium animalis A12 in the Control of Diabetes or Hyperlipidemia, Especially Weight Gain or Obesity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910818555.XA CN110604749B (zh) | 2019-08-30 | 2019-08-30 | 动物双歧杆菌a12及其在控制糖尿病或高血脂症特别是体重增加或肥胖中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110604749A true CN110604749A (zh) | 2019-12-24 |
CN110604749B CN110604749B (zh) | 2020-08-14 |
Family
ID=68890808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910818555.XA Active CN110604749B (zh) | 2019-08-30 | 2019-08-30 | 动物双歧杆菌a12及其在控制糖尿病或高血脂症特别是体重增加或肥胖中的应用 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN110604749B (zh) |
NL (1) | NL2026360B1 (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111676175A (zh) * | 2020-07-20 | 2020-09-18 | 广东南芯医疗科技有限公司 | 一株动物双歧杆菌nx-6及其在制备降脂减肥药物中的应用 |
CN112725384A (zh) * | 2021-03-16 | 2021-04-30 | 北京农学院 | 利用双歧杆菌特别是a12发酵制备醛类香料的方法及其应用 |
CN112961808A (zh) * | 2021-03-31 | 2021-06-15 | 盐城维康生物科技有限公司 | 一种降脂减肥的乳双岐杆菌制剂及其制备方法 |
CN113018319A (zh) * | 2021-01-21 | 2021-06-25 | 中南大学 | 一种用于缓解因长期低剂量辐射暴露所致胰岛素抵抗的复合菌剂及其应用 |
CN113142303A (zh) * | 2021-01-18 | 2021-07-23 | 重庆市天友乳业股份有限公司 | 一种具有预防肥胖功效的酸奶及其制备方法 |
CN113349375A (zh) * | 2021-01-07 | 2021-09-07 | 中国海洋大学 | 一种改善动脉粥样硬化脂质代谢动物双歧杆菌f1-7和磷虾油组合物制备方法及应用 |
CN114028444A (zh) * | 2021-12-03 | 2022-02-11 | 南京北极光生物科技有限公司 | 一种益生菌组合物及其在缓解抑郁症与减少脂堆积上的应用 |
CN114350547A (zh) * | 2021-12-17 | 2022-04-15 | 四川省医学科学院·四川省人民医院 | 一种乳双歧杆菌菌株b-622及其在制备治疗糖尿病药物中的应用 |
CN115245523A (zh) * | 2021-01-28 | 2022-10-28 | 上海市第六人民医院 | 青春双歧杆菌在制备脂肪吸收抑制剂中的应用 |
CN115990193A (zh) * | 2022-08-17 | 2023-04-21 | 北京农学院 | 动物双歧杆菌在妊娠期高血糖中的应用 |
CN116426442A (zh) * | 2023-06-01 | 2023-07-14 | 内蒙古兰格格乳业有限公司 | 一种降低体脂及提升抗氧化能力的益生菌及其应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009004076A2 (en) * | 2007-07-05 | 2009-01-08 | Nestec S.A. | Supplemention of maternal diet |
EP2318022A1 (en) * | 2008-06-20 | 2011-05-11 | Danisco A/S | New uses of lactic acid bacteria and bifidobacteria |
CN102458415A (zh) * | 2009-06-19 | 2012-05-16 | 丹尼斯科公司 | 治疗糖尿病及相关病症的双歧杆菌 |
CN102670661A (zh) * | 2011-03-08 | 2012-09-19 | 惠宏襄 | 用于刺激胰高血糖素样肽-1分泌的药物 |
CN103619343A (zh) * | 2010-12-07 | 2014-03-05 | 高等科学研究委员会 | 双歧杆菌cect7765及其在预防和/或治疗超重、肥胖和相关病理中的用途 |
CN106617096A (zh) * | 2017-02-15 | 2017-05-10 | 中国农业大学 | 一种增强胰岛功能的双歧杆菌及其应用 |
-
2019
- 2019-08-30 CN CN201910818555.XA patent/CN110604749B/zh active Active
-
2020
- 2020-08-27 NL NL2026360A patent/NL2026360B1/en active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009004076A2 (en) * | 2007-07-05 | 2009-01-08 | Nestec S.A. | Supplemention of maternal diet |
EP2318022A1 (en) * | 2008-06-20 | 2011-05-11 | Danisco A/S | New uses of lactic acid bacteria and bifidobacteria |
CN102458415A (zh) * | 2009-06-19 | 2012-05-16 | 丹尼斯科公司 | 治疗糖尿病及相关病症的双歧杆菌 |
CN104770739A (zh) * | 2009-06-19 | 2015-07-15 | 杜邦营养生物科学有限公司 | 治疗糖尿病及相关病症的双歧杆菌 |
CN103619343A (zh) * | 2010-12-07 | 2014-03-05 | 高等科学研究委员会 | 双歧杆菌cect7765及其在预防和/或治疗超重、肥胖和相关病理中的用途 |
CN102670661A (zh) * | 2011-03-08 | 2012-09-19 | 惠宏襄 | 用于刺激胰高血糖素样肽-1分泌的药物 |
CN106617096A (zh) * | 2017-02-15 | 2017-05-10 | 中国农业大学 | 一种增强胰岛功能的双歧杆菌及其应用 |
Non-Patent Citations (5)
Title |
---|
CHEN, P等: "Screening for potential new probiotic based on probiotic properties and α-glucosidase inhibitory activity", 《FOOD CONTROL》 * |
EBRAHIMI, Z等: "Effect of symbiotic supplementation on glycemic control, lipid profiles and microalbuminuria in patients with non-obese type 2 diabetes: A randomized, double-blind, clinical trial", 《JOURNAL OF DIABETES AND METABOLIC DISORDERS》 * |
MOKKALA, K.等: "Bifidobacterium lactis 420 and fish oil enhance intestinal epithelial integrity in Caco-2 cells", 《NUTRITION RESEARCH》 * |
TONG LI等: "Bifidobacterium from breastfed infant faeces prevent high‐fat‐diet‐induced glucose tolerance impairment, mediated by the modulation of glucose intake and the incretin hormone secretion axis", 《JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE》 * |
朱宗涛等: "两株动物双歧杆菌的潜在干预糖尿病作用", 《食品工业科技》 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111676175B (zh) * | 2020-07-20 | 2022-05-24 | 广东南芯医疗科技有限公司 | 一株动物双歧杆菌nx-6及其在制备降脂减肥药物中的应用 |
CN111676175A (zh) * | 2020-07-20 | 2020-09-18 | 广东南芯医疗科技有限公司 | 一株动物双歧杆菌nx-6及其在制备降脂减肥药物中的应用 |
CN113349375A (zh) * | 2021-01-07 | 2021-09-07 | 中国海洋大学 | 一种改善动脉粥样硬化脂质代谢动物双歧杆菌f1-7和磷虾油组合物制备方法及应用 |
CN113142303A (zh) * | 2021-01-18 | 2021-07-23 | 重庆市天友乳业股份有限公司 | 一种具有预防肥胖功效的酸奶及其制备方法 |
CN113018319A (zh) * | 2021-01-21 | 2021-06-25 | 中南大学 | 一种用于缓解因长期低剂量辐射暴露所致胰岛素抵抗的复合菌剂及其应用 |
CN115245523A (zh) * | 2021-01-28 | 2022-10-28 | 上海市第六人民医院 | 青春双歧杆菌在制备脂肪吸收抑制剂中的应用 |
CN112725384B (zh) * | 2021-03-16 | 2022-02-18 | 北京农学院 | 利用双歧杆菌特别是a12发酵制备醛类香料的方法及其应用 |
CN112725384A (zh) * | 2021-03-16 | 2021-04-30 | 北京农学院 | 利用双歧杆菌特别是a12发酵制备醛类香料的方法及其应用 |
CN112961808A (zh) * | 2021-03-31 | 2021-06-15 | 盐城维康生物科技有限公司 | 一种降脂减肥的乳双岐杆菌制剂及其制备方法 |
CN114028444A (zh) * | 2021-12-03 | 2022-02-11 | 南京北极光生物科技有限公司 | 一种益生菌组合物及其在缓解抑郁症与减少脂堆积上的应用 |
CN114350547A (zh) * | 2021-12-17 | 2022-04-15 | 四川省医学科学院·四川省人民医院 | 一种乳双歧杆菌菌株b-622及其在制备治疗糖尿病药物中的应用 |
CN114350547B (zh) * | 2021-12-17 | 2023-05-16 | 四川省医学科学院·四川省人民医院 | 一种乳双歧杆菌菌株b-622及其在制备治疗糖尿病药物中的应用 |
CN115990193A (zh) * | 2022-08-17 | 2023-04-21 | 北京农学院 | 动物双歧杆菌在妊娠期高血糖中的应用 |
CN115990193B (zh) * | 2022-08-17 | 2024-04-19 | 北京农学院 | 动物双歧杆菌在妊娠期高血糖中的应用 |
CN116426442A (zh) * | 2023-06-01 | 2023-07-14 | 内蒙古兰格格乳业有限公司 | 一种降低体脂及提升抗氧化能力的益生菌及其应用 |
Also Published As
Publication number | Publication date |
---|---|
NL2026360B1 (en) | 2022-07-26 |
CN110604749B (zh) | 2020-08-14 |
NL2026360A (en) | 2021-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110604749B (zh) | 动物双歧杆菌a12及其在控制糖尿病或高血脂症特别是体重增加或肥胖中的应用 | |
CN110150669B (zh) | 一种适于糖尿病患者食用的益生菌组合物及其应用 | |
KR102033031B1 (ko) | 락토바실러스 플란타룸 tci378 및 지방 감소 및 위장 기능 향상에 있어서 그의 용도 | |
CN114717147B (zh) | 一种鼠李糖乳杆菌制备的缓解脂肪肝与肥胖的后生元及其应用 | |
CN111560330B (zh) | 一种具有免疫调节、抗炎和抗宫颈癌作用的干酪乳杆菌及应用 | |
CN114181864B (zh) | 一种鼠李糖乳杆菌hf01及其应用 | |
CN110747146A (zh) | 具有降解尿酸作用的格氏乳杆菌lg08及其应用 | |
CN114107121B (zh) | 一种凝结芽孢杆菌及其在酒精性肝病的治疗中的应用 | |
CN109593678B (zh) | 长双歧杆菌yh295及其在制备降低腹型肥胖风险产品中的应用 | |
CN116790448B (zh) | 一株能够缓解便秘和腹泻的瑞士乳杆菌opb102和应用 | |
CN116286551B (zh) | 长双歧杆菌婴儿亚种在调节体内脂肪代谢、塑形减脂改善肥胖方面的应用 | |
CN115287240A (zh) | 一株具有高尿酸血症及痛风防治作用的植物乳杆菌及其应用 | |
CN117264829A (zh) | 一种用于防治高胆固醇血症的植物乳杆菌及其发酵制品与应用 | |
CN116254190A (zh) | 一种副干酪乳杆菌亚种及其应用 | |
CN113151070B (zh) | 一株可提高肠道中克里斯藤森菌科相对丰度的发酵乳杆菌 | |
CN117004503B (zh) | 一株唾液联合乳杆菌mb1及其在制备助睡眠和调理肠胃食品药品中的应用 | |
CN115074276B (zh) | 一株能够缓解非酒精性脂肪肝的普拉梭菌及其应用 | |
CN114540257B (zh) | 一种卷曲乳杆菌iob901及其在降糖降脂方面的应用 | |
CN113717883B (zh) | 促进机体健康长寿的植物乳杆菌flpl05及其应用 | |
CN115181710A (zh) | 一株唾液乳杆菌b12wu及其应用 | |
CN114617265A (zh) | 一种灭活干酪乳杆菌iob-p9后生元粉在降糖方面的应用 | |
CN116376770B (zh) | 一种鼠李糖乳酪杆菌rh0121在制备降血糖制品中的应用 | |
CN117363524B (zh) | 一株格氏乳杆菌my4及其在制备助睡眠和美白药品中的应用 | |
CN113862168B (zh) | 一种副拟杆菌及其在改善肥胖或其代谢相关疾病中的应用 | |
CN117286045B (zh) | 一株长双歧杆菌长亚种ks2及其在制备抗衰老药品中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20220530 Address after: 102206 room 123, 1st floor, building 57, Southeast of zhuxinzhuang village, Jingchang highway, Huilongguan town, Changping District, Beijing Patentee after: BEIJING BEINONG HONGZE BIOTECHNOLOGY Co.,Ltd. Address before: 215125 Building 8, 3355 sutongli highway, chefangqiangang village, Luzhi Town, Wuzhong District, Suzhou City, Jiangsu Province Patentee before: Suzhou Bohao Food Co.,Ltd. Effective date of registration: 20220530 Address after: 215125 Building 8, 3355 sutongli highway, chefangqiangang village, Luzhi Town, Wuzhong District, Suzhou City, Jiangsu Province Patentee after: Suzhou Bohao Food Co.,Ltd. Address before: 102206 No. 7 Nong Road, Huilongguan, Beijing, Changping District Patentee before: BEIJING University OF AGRICULTURE |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20191224 Assignee: Guangxi Goldenthroat Healthcare Products Co.,Ltd. Assignor: BEIJING BEINONG HONGZE BIOTECHNOLOGY Co.,Ltd. Contract record no.: X2022980010566 Denomination of invention: Animal Bifidobacterium A12 and its application in the control of diabetes or hyperlipidemia, especially weight gain or obesity Granted publication date: 20200814 License type: Common License Record date: 20220715 |