CN110585355A - Preparation method of traditional Chinese medicine decoction pieces for preventing and treating oral ulcer - Google Patents
Preparation method of traditional Chinese medicine decoction pieces for preventing and treating oral ulcer Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine decoction pieces, in particular to a preparation method of traditional Chinese medicine decoction pieces for preventing and treating oral ulcer, which is different from the traditional preparation method of decoction piece tablets, adopts a technical method of film-coated emulsion tape casting molding, quickly prepares decoction pieces with high efficiency, quickness, dust free and low cost, adopts traditional Chinese medicine clinker and traditional Chinese medicine extract, can reduce the permeability of capillary cells, weaken hyperemia and edema and improve the oxygen tension of local tissues, can accelerate cell division activity, synthesis of collagen fiber and new blood vessel, improve formation of granulation tissue and epithelium, prevent and treat oral ulcer, clean oral cavity, maintain oral nutrition balance, the decoction pieces are easy to dry, have low water content, good effect of preventing and treating dental ulcer, wide raw material source, simple preparation method, easy storage and prolonged storage life.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine decoction pieces, and particularly relates to a preparation method of traditional Chinese medicine decoction pieces for preventing and treating dental ulcer.
Background
The traditional Chinese medicine decoction pieces are prepared from plants, animals and ores, most of the traditional Chinese medicine decoction pieces are processed, or sliced, or smashed or processed into powder, and the traditional Chinese medicine decoction pieces have heavy smell and large dust. The bulk traditional Chinese medicine decoction pieces are dispensed in the traditional Chinese medicine room, various dusts in the whole traditional Chinese medicine room are scattered, the medicinal flavor is diffused, leakage, overflow easily occur in the bulk traditional Chinese medicine decoction piece dispensing, and the decoction pieces are often scattered on a dispensing table and a floor to cause waste. In addition, in the dispensing process of bulk decoction pieces, dispensing personnel need to touch the prescription taken by different patients and take medicines, which is not in accordance with the sanitary requirement. The decoction pieces are exposed in the air for a long time and are easy to taint with odor and deteriorate. The dust is reduced, the working environment is greatly improved, and the labor intensity of workers is also reduced; because each package of the tablets is marked with name, quantity, production place, production batch number and the like, the supervision and rechecking of patients are convenient, the standards of water, impurities and the like during processing by a tablet drinking factory are correspondingly improved, and the quality of the tablets is improved from another aspect. Oral ulcer is a superficial ulcer occurring on the oral mucosa, and is a common disease of the oral mucosa, and the size of the ulcer varies from rice grains to soybeans. It is caused by vitamin B deficiency or pungent food. The main symptoms are red swelling inflammation or blister formation, ulcer erosion and the like of the parts such as lips, tongue and the like. The disease is one of the most common diseases in oral mucosa, is common in young and strong years and is equivalent to recurrent oral ulcer, and the technical personnel in the field need to develop a preparation method of a traditional Chinese medicine beverage for preventing and treating oral ulcer so as to meet higher requirements in practical production and use.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a preparation method of traditional Chinese medicine decoction pieces for preventing and treating oral ulcer, which can effectively reduce the incidence rate of oral ulcer, improve the cure rate of oral ulcer, clean the oral cavity and avoid generating drug resistance.
The invention is realized by the following technical scheme:
a preparation method of traditional Chinese medicine decoction pieces for preventing and treating oral ulcer comprises the following steps:
(1) crushing 4.3 parts of badam without impurities into coarse powder, sieving with a 100-mesh sieve, removing impurities and Bisika by 2.7 parts of ~.9 parts, sieving with a 100-mesh sieve, crushing 2.7 parts of phoenix tree seed by 2.7 parts of ~.9 parts, sieving with a 100-mesh sieve, drying in the sun, crushing 4.2 parts of abalone fruit seed by 4.2 ~.4 parts, putting the crushed raw materials into a clean container, adding 33 ~ parts of water, stopping heating after boiling for 1 ~.5 hours according to boiling time, discharging minced meat, putting the cooked minced meat into a barrel, mixing a leavening agent of lactobacillus bulgaricus and streptococcus thermophilus according to a ratio of 1:1 at 45 ~ ℃, adding 0.1 ~.4 parts of mixed leavening agent, fermenting for 25 hours at 40 ℃, and fermenting for 40 ~ hours;
(2) stirring 7.4 ~ 7.8.8 parts of winter cherry juice and 8.9 ~ 9.5.5 parts of compound mangosteen juice in a lump machine, adding 95 ~ 100 parts of the fermented paste obtained in the step (1), stirring uniformly for 3 ~ 5 minutes, taking out the mixture, piling the mixture into a pile, covering the pile with PVDC plastic cloth, fermenting for 42 ~ 65 hours at 33 ~ 35 ℃ and 70 ~ 80% relative humidity, after cracks appear on the surface of the pile, crushing the pile, putting 5.1 ~ 5.5 parts of American ginseng and 3.4 ~ 3.6.6 parts of ganoderma spore powder into warm water at 50 ~ 52 ℃ for soaking for 24 ~ 28 minutes at constant temperature, draining, covering an EVOH plastic film, sealing the pile for 19 ~ 21 hours, crushing, putting into a frying pan at 74 ~ 80 ℃ for frying for 6 ~ 7 minutes at constant temperature, naturally cooling at room temperature, and obtaining traditional Chinese medicine clinker for later use;
(3) then 19 parts by weight of ~ parts by weight of smoke tree wax, 4 parts by weight of insect wax, 0.4 part by weight of ~.9 parts by weight of plant latex, 11 ~ parts by weight of polyvinylpyrrolidone, 2 ~ parts by weight of sodium dodecyl benzene sulfonate and 0.4 part by weight of sodium alginate ~ are placed in a reaction vessel provided with a reflux device, the reaction vessel is heated to 60 ~ ℃ to be melted, stirring is started, the rotating speed is controlled to be 1000 ~ rpm and is controlled to be uniform, then 48 ~ parts by weight of distilled water and 0.04 ~.1 part by weight of vitamin C are added, stirring and emulsification is carried out for 40 ~ min, and vinegar is added to ensure that the pH value is 7.2 ~.5, thus obtaining a film-coated emulsion;
(4) cleaning and crushing 3.7 ~ 3.9.9 parts of guava, 4.9 ~ 5.3.3 parts of fresh eucommia leaves, 6.2 ~ 6.8.8 parts of dogwood and 5.9 ~ 6.3.3 parts of coriander, adding 37 ~ 45 parts of water, decocting in an iron pot at 100 ℃ for 1 ~ 2 hours, filtering to obtain filter residue and a first decoction liquid, uniformly mixing the filter residue and 0.38 ~ 0.42.42 part of edible salt, fermenting in a closed manner at 33 ~ 35 ℃ for 30 ~ 32 hours, adding water, decocting, filtering to obtain a second decoction liquid, uniformly mixing the first decoction liquid and the second decoction liquid, decocting for 4 ~ 5 minutes, and spray drying to obtain a traditional Chinese medicine extract;
(5) mixing and stirring 20 ~ parts of the traditional Chinese medicine extract obtained in the step (4), 30 ~ parts of the film-coated emulsion obtained in the step (3) and 33 ~ parts of the clinker obtained in the step (2) uniformly, adding 0.03 ~.05 part of citric acid, 0.05 ~.1 part of thyme powder, 0.04 ~.08 part of calcium citrate and 0.02 ~.1 part of calcium chloride, mixing uniformly, feeding into a 40 ~ ℃ screw film forming machine, passing through a homogenizer, a filter, conveying to a casting die lip, continuously running from the casting die lip to 15 ~ cm away from the die lip at the temperature of 15 ~ ℃ to cool the polytetrafluoroethylene casting support at ~ ℃, carrying out air knife 30-degree angle of 40 ~ mm and gap of 1.6 ~.0 mm, carrying out compressed air of 0.3 ~.38 MPa, volatilizing 24 ~ hours at 35 9640 ℃ to obtain a casting support, cutting into slices, and drying the slices at ~ ℃ to 394% of water content of ~% to form tablets;
(6) sterilizing, packaging, and labeling.
Further, the plant latex is a mixture of eucommia ulmoides latex and Russian dandelion latex, wherein the solid content of the emulsion is 34 ~ 43%, the viscosity of the emulsion is 10 ~ 70 mPa.s, the centrifugal stability, the storage stability and the dilution stability of the emulsion are grade 1, and the ratio of the eucommia ulmoides latex to the dandelion latex is 1:1 in parts by weight.
Further, the preparation method comprises removing core and skin from fresh mangosteen pulp 12 ~ 14 weight parts, pulverizing, adding Jerusalem artichoke juice 17.8 ~ 18.8.8 weight parts and at 49 ~ 51 deg.C, grinding, filtering, and collecting juice to obtain composite mangosteen juice.
Further, the sour berry juice is prepared by the following steps of taking 23 ~ parts by weight of fresh sour berry, adding 25 ~ parts by weight of water and sterile water with the temperature of 54 ~ ℃, grinding, filtering and taking juice to obtain the sour berry juice.
Further, the wall-broken spore powder produced by green lucid ganoderma or black lucid ganoderma originally produced at east foot of Zhangguangdingjie mountain is selected as the spore powder, the wall-broken rate is greater than 98%, the lucid ganoderma spore powder produced in the current year is selected, all the spore powder needs to be stored at the temperature of-20 ℃, the lucid ganoderma spore powder has no peculiar smell, is not rotten and mildewed, the total number of colonies meets the national standard, the spore powder is sampled and inspected, the spore powder is plump under a microscope, the abnormal particles are less than 1 ~ 5%, and the impurities of the non-spore powder in the raw materials are less than 1 ~ 3%.
The invention has the beneficial effects that:
the invention is a traditional Chinese medicine drink which takes medicinal raw materials such as almonds, bristlegrass, sour berries, guavas, fresh eucommia leaves, dogwoods, coriander and the like as main raw materials, is rich in health beneficial components such as compound vitamins, mineral trace elements and the like, is added with other pure natural ingredients without any toxic or side effect, is prepared by reasonable proportion, can supplement human body energy, remarkably enhance the oxygen carrying capacity of red blood cells, improve the degree of oxygen saturation of oral blood in an anoxic environment, accelerate the discharge of sports lactic acid, quickly prevent and relieve oral inflammation reaction, and can directly inhibit the growth and the propagation of anaerobic bacteria; on the other hand, the medicinal components cause the contraction of capillary vessels, the reduction of permeability, the reduction of wound surface exudation, edema and congestion degrees, can greatly reduce secondary infection and prevent the ulcer surface from aggravating; the improvement of local tissue oxygen tension can accelerate the activation of cell division, accelerate the synthesis of collagen fiber and new blood vessel, and improve the formation of granulation tissue and epithelium. Easy carrying, good sealing performance, long shelf life, convenient drinking and no toxic or side effect. The acidic berries contain jerusalem artichoke components, so that the antibacterial function is well coordinated, such as flavonoid components, the pain feeling of the oral ulcer is relieved, and the mild and soft effects are rapid. The PVDC and the EVOH are adopted to block gas, so that the further improvement of fermentation conditions is realized, the migration and absorption of medicinal components are facilitated, and the combination of the extracts of the guava, the fresh eucommia ulmoides, the dogwood and the coriander can promote the rapid healing of wounds, relieve pain, improve metabolism and protect the normal structural function of cells. Promoting skin and subcutaneous tissue to absorb sufficient nutrition, and promoting tissue mucosa repair. Calcium citrate and calcium chloride are used for film-covering forming to play a role in crosslinking, so that the mechanical strength of the decoction pieces is improved. The decoction pieces consist of plant emulsion of eucommia ulmoides and Russian dandelion, Chinese wax, cotinus coggygria wax and other auxiliary materials, the traditional Chinese medicine extract is subjected to coating tape casting by adopting the film-coated emulsion, so that the remarkable defects of large dust and low preparation efficiency of the conventional tabletting method are overcome, and the preparation method is simple, has low equipment requirement, can realize automatic industrial production, has low cost and the like and has the outstanding advantages. The plant emulsion and the wax component in the emulsion are nontoxic and edible, and have good synergistic effect, so that the decoction pieces have good toughness, are not easy to break, and have good medicinal value. The effective components of the raw materials interact with each other, so that the immunity and the resistance to oral ulcer can be effectively enhanced, and if the decoction pieces prepared by the invention are drunk for a long time, the breeding of pathogenic putrefying bacteria in the oral cavity can be inhibited, the oral cavity function can be adjusted, so that the incidence rate of the oral ulcer is reduced, the effect of effectively preventing and treating the oral ulcer is achieved, and the decoction pieces can be drunk into the abdomen to play the roles of tonifying qi and enriching the blood, tonifying the spleen and warming the stomach.
Compared with the prior art, the invention has the following advantages:
the preparation method of the traditional Chinese medicine decoction pieces for preventing and treating dental ulcer disclosed by the invention is different from the traditional decoction piece preparation method, adopts the tape casting technical method, quickly prepares the decoction pieces with high efficiency, quickness, dust-free property and low cost, and most of the used raw materials are medicinal raw materials, and if the emulsion with the coating also has medicinal efficacy, the outstanding problem of overlarge dust generated by the preparation of the traditional decoction pieces is solved, the prepared decoction pieces contain clinker, have anti-inflammatory effects of reducing capillary cell permeability, weakening congestion and edema, inhibiting inflammatory cell transfer to inflammatory parts, preventing inflammatory mediator from reacting and the like, do not cause the problems of dyspepsia and the like, ensure safety and sanitation, the decoction pieces are easy to dry, have low water content, good effect of preventing and treating dental ulcer, wide raw material sources, simple preparation method, easy storage and prolonged storage life, and can be taken together with decoction without changing the traditional administration form; the taste of the decoction pieces is changed when the decoction pieces are swallowed after being taken with water, and the traditional decoction pieces which are swallowed after being taken with water have larger grain diameters.
Detailed Description
The invention is illustrated by the following specific examples, which are not intended to be limiting.
Example 1
A preparation method of traditional Chinese medicine decoction pieces for preventing and treating oral ulcer comprises the following steps:
(1) crushing 4.7 parts of badam without impurities into coarse powder, sieving with a 100-mesh sieve, removing impurities and crushing 2.9 parts of barnyard, sieving with a 100-mesh sieve, crushing 2.9 parts of phoenix tree seeds, sieving with a 100-mesh sieve, drying in the sun, crushing 4.4 parts of abalone fruit seeds, putting the crushed raw materials into a clean container, adding 39 parts of water, stopping heating after boiling for 1.5 hours, discharging minced meat, putting the cooked minced meat into a barrel, mixing lactobacillus bulgaricus and streptococcus thermophilus according to a ratio of 1:1 at 50 ℃, adding 0.4 part of mixed leavening agent, fermenting for 25 hours at 40 ℃, and fermenting for 45 hours;
(2) stirring 7.8 parts of sour pulp juice and 9.5 parts of compound mangosteen juice in a lump machine, taking 100 parts of fermented paste, adding the fermented paste, stirring uniformly for 5 minutes, taking out the mixture, piling the mixture, covering the mixture with PVDC plastic cloth, fermenting for 65 hours at 35 ℃ and 80% relative humidity, after cracks appear on the surface of the pile, crushing the pile, putting 5.5 parts of American ginseng and 3.6 parts of ganoderma spore powder into warm water with the temperature of 50 ~ 52 ℃ for soaking at constant temperature for 28 minutes, draining, taking out, covering an EVOH plastic film, sealing and piling for 21 hours, crushing, putting into a frying pan with the temperature of 80 ℃ for frying at constant temperature for 7 minutes, and naturally cooling at room temperature to obtain traditional Chinese medicine clinker for later use;
(3) 22 parts of cotinus coggygria wax, 6 parts of Chinese insect wax, 1.9 parts of plant latex, 13 parts of polyvinylpyrrolidone, 5 parts of sodium dodecyl benzene sulfonate and 1 part of sodium alginate by weight are placed in a reaction container provided with a reflux device, heated to 100 ℃ to be melted, stirred, controlled at the rotating speed of 2000rpm to uniformly mix the materials, 48 ~ 77 parts of distilled water and 0.1 part of vitamin C are added, stirred and emulsified for 120min, and vinegar is added to ensure that the pH value is 7.2, so that a film-coated emulsion is obtained;
(4) cleaning and crushing 3.9 parts of guava, 5.3 parts of fresh eucommia leaves, 6.8 parts of dogwood and 6.3 parts of coriander, adding 45 parts of water, decocting for 2 hours in an iron pan at 100 ℃, and filtering to obtain filter residue and a first decoction liquid; mixing the filter residue and 0.42 part of edible salt uniformly, fermenting in a sealed manner at the temperature of 35 ℃ for 32 hours, adding water for decocting, filtering, and taking the decoction to obtain a second decoction; mixing the first decoction and the second decoction, decocting for 5min, and spray drying to obtain Chinese medicinal extract;
(5) mixing 23 parts of the traditional Chinese medicine extract obtained in the step (4), 36 parts of the film-coated emulsion obtained in the step (3) and 35 parts of the traditional Chinese medicine clinker obtained in the step (2) uniformly, adding 0.05 part of citric acid, 0.1 part of thyme powder, 0.08 part of calcium citrate and 0.1 part of calcium chloride, uniformly mixing, feeding into a 45 ℃ screw film forming machine, homogenizing by a homogenizer, filtering, conveying to a casting die lip, cooling and casting a polytetrafluoroethylene support body at 20 ℃ which is continuously operated at a distance of 20cm from the die lip by the casting die lip, cooling and casting the polytetrafluoroethylene support body by an air knife at an angle of 30 degrees of 55mm, performing compressed air at 0.38MPa, volatilizing at 40 ℃ for 32 hours to obtain a sheet, cutting into decoction pieces, and drying at 45 ℃ to obtain formed decoction pieces with the water content of 6%;
(6) sterilizing, packaging, and labeling.
Further, the plant latex is a mixture of eucommia ulmoides latex and Russian dandelion latex, wherein the solid content of the emulsion is 43%, the viscosity of the emulsion is 70 mPa.s, the centrifugal stability, the storage stability and the dilution stability of the emulsion are grade 1, and the ratio of the eucommia ulmoides latex to the dandelion latex is 1:1 in parts by weight.
Further, the preparation method comprises removing core and skin from fresh mangosteen pulp 12 ~ 14 weight parts, pulverizing, adding Jerusalem artichoke juice 18.8 weight parts at 51 deg.C, grinding, filtering, and collecting juice to obtain composite mangosteen juice.
Further, the sour berry juice is prepared by the following steps: taking 24 parts by weight of fresh berry, adding 26 parts by weight of water and sterile water with the temperature of 56 ℃, grinding, filtering, and taking juice to obtain the berry juice.
Further, the spore powder is wall-broken spore powder of green lucid ganoderma originally produced at eastern foot of Zhang Guangdong mountain or lucid ganoderma produced by black lucid ganoderma, and the wall-breaking rate is more than 98%; selecting ganoderma lucidum spore powder produced in the current year, and storing all the spore powder at the temperature of minus 20 ℃; the ganoderma lucidum spore powder has no peculiar smell, no rot and no mildew, and the total number of colonies meets the national standard; performing spot check on spore powder, wherein the spore powder has plump particles under a microscope, and the number of abnormal particles is less than 5%; the non-spore powder impurity in the raw material is less than 3%.
Example 2
A preparation method of traditional Chinese medicine decoction pieces for preventing and treating oral ulcer comprises the following steps:
(1) crushing 4.3 parts of badam without impurities into coarse powder, sieving with a 100-mesh sieve, removing impurities and crushing 2.7 parts of barnyard, sieving with a 100-mesh sieve, crushing 2.7 parts of phoenix tree seeds, sieving with a 100-mesh sieve, drying in the sun, crushing 4.2 parts of abalone seeds, putting the crushed raw materials into a clean container, adding 33 parts of water, boiling for 1 hour, stopping heating, discharging minced meat, putting the cooked minced meat into a barrel, mixing lactobacillus bulgaricus and streptococcus thermophilus according to a ratio of 1:1 at the temperature of 45 ~ 50 ℃, adding 0.1 part of mixed leavening agent, fermenting for 25 hours at the temperature of 40 ℃, and fermenting for 40 hours;
(2) stirring 7.4 parts of winter cherry juice and 8.9 parts of compound mangosteen juice in a lump machine, taking 95 parts of the fermented paste obtained in the step (1), adding, stirring and mixing uniformly for 3 ~ 5 minutes, taking out the mixture, stacking the mixture into a pile, covering the pile with PVDC plastic cloth, fermenting for 42 hours at 33 ℃ and 70% of relative humidity until cracks appear on the surface of the pile, crushing the pile, soaking 5.1 parts of American ginseng and 3.4 parts of ganoderma spore powder in warm water at 50 ℃ for 24 minutes at constant temperature, draining, taking out, covering an EVOH plastic film, sealing, stacking for 19 hours, crushing, frying in a frying pan at 74 ℃ at constant temperature for 6 ~ 7 minutes, and naturally cooling at room temperature to obtain Chinese medicine clinker for later use;
(3) then 19 parts of cotinus coggygria wax, 4 parts of Chinese insect wax, 0.4 part of plant latex, 11 parts of polyvinylpyrrolidone, 2 parts of sodium dodecyl benzene sulfonate and 0.4 part of sodium alginate by weight are placed in a reaction vessel provided with a reflux device, heated to 100 ℃ to be melted, started to stir, controlled at the rotating speed of 1000rpm to uniformly mix the materials, then 48 parts of distilled water and 0.04 part of vitamin C are added, stirred and emulsified for 40min, and vinegar is added to ensure that the pH value is 7.2, thus obtaining a film-coated emulsion;
(4) cleaning and crushing 3.7 parts of guava, 4.9 parts of fresh eucommia leaves, 6.2 parts of dogwood and 5.9 parts of coriander, adding 37 parts of water, decocting for 1 hour at 100 ℃ in an iron pot, filtering to obtain filter residue and a first decoction liquid, uniformly mixing the filter residue and 0.38 ~ 0.42.42 parts of edible salt, fermenting for 30 hours in a closed manner at the temperature of 33 ~ 35 ℃, adding water, decocting, filtering, taking a second decoction liquid, uniformly mixing the first decoction liquid and the second decoction liquid, decocting for 4 minutes, and spray-drying to obtain a traditional Chinese medicine extract;
(5) mixing and stirring 20 parts of the traditional Chinese medicine extract obtained in the step (4), 30 parts of the film-coated emulsion obtained in the step (3) and 33 parts of the traditional Chinese medicine clinker obtained in the step (2) uniformly, adding 0.03 ~.05 part of citric acid, 0.1 part of thyme powder, 0.04 part of calcium citrate and 0.02 part of calcium chloride, uniformly mixing, feeding into a 40 ℃ screw film forming machine, homogenizing by a homogenizer and a filter, conveying to a casting die lip, continuously running by 15 cm away from the die lip by 15 cm, cooling polytetrafluoroethylene on a casting support body at 15 ℃, keeping a gap of 30 degrees at an angle of 40mm by an air knife of 1.6mm, compressing air of 0.3MPa, volatilizing for 24 hours at 35 ℃ to obtain a sheet, cutting into decoction pieces, and drying at 40 ℃ to obtain formed decoction pieces with the water content of 6%;
(6) sterilizing, packaging, and labeling.
Further, the plant latex is a mixture of eucommia ulmoides latex and Russian dandelion latex, wherein the solid content of the emulsion is 43%, the viscosity of the emulsion is 70 mPa.s, the centrifugal stability, the storage stability and the dilution stability of the emulsion are grade 1, and the ratio of the eucommia ulmoides latex to the dandelion latex is 1:1 in parts by weight.
Further, the preparation method comprises removing core and skin from fresh mangosteen pulp 12 ~ 14 weight parts, pulverizing, adding Jerusalem artichoke juice 17.8 ~ weight parts at 49 deg.C, grinding, filtering, and collecting juice to obtain compound mangosteen juice.
Further, the sour berry juice is prepared by the following steps: taking 23 parts by weight of fresh berry, adding 25 parts by weight of water and sterile water with the temperature of 54 ℃, grinding, filtering, and taking juice to obtain the berry juice.
Further, the spore powder is wall-broken spore powder of green lucid ganoderma originally produced at eastern foot of Zhang Guangdong mountain or lucid ganoderma produced by black lucid ganoderma, and the wall-breaking rate is more than 98%; selecting ganoderma lucidum spore powder produced in the current year, and storing all the spore powder at the temperature of minus 20 ℃; the ganoderma lucidum spore powder has no peculiar smell, no rot and no mildew, and the total number of colonies meets the national standard; performing spot check on spore powder, wherein the spore powder has plump particles under a microscope, and the number of abnormal particles is less than 5%; the non-spore powder impurity in the raw material is less than 3%.
Comparative example 1
This comparative example compares to example 2 in step (5) the clinker ingredient of the traditional Chinese medicine of step (2) is omitted, except that the process steps are otherwise the same.
Comparative example 2
This comparative example is compared with example 2 in that in step (5), the ingredients of the chinese medicinal extract obtained in step (4) are the same except for the other process steps.
Table 1 experimental results of the examples and comparative examples
Note: the sensory organs take a proper amount of samples to be placed in a white porcelain dish, and the samples are viewed by the moon and smelled by the nose under natural light, wherein the samples are taken and soaked without abnormal taste in the eyes, the nose and the mouth; the moisture content was measured according to the method specified in GB 5009.3; ash content is measured according to the method specified in GB 5009.4; sulfur dioxide is measured according to the method specified in GBT 50093.4; the food additive is used within a range, the variety and the using amount of the food additive meet the requirements of GB2760, the mycotoxin limit meets the requirements of GB2761, the pollutant limit meets the requirements of GB2762, and the maximum pesticide residue limit in the food meets the requirements of GB2763 and meets the requirements of Chinese pharmacopoeia 2015 edition, namely the food is qualified in sanitation; the safety acute oral toxicity test is of actual non-toxic grade, and the mucosa irritation test has no obvious irritation.
As can be seen from Table 1, the medicine provided by the invention can effectively reduce the incidence rate of oral ulcer, improve the cure rate of oral ulcer, reduce the incidence rate of oral ulcer, and reduce the relative usage of oral ulcer powder, so that the cure rate of oral ulcer is obviously improved.
Claims (5)
1. A preparation method of traditional Chinese medicine decoction pieces for preventing and treating oral ulcer is characterized by comprising the following steps:
(1) crushing 4.3 parts of badam without impurities into coarse powder, sieving with a 100-mesh sieve, removing impurities and Bisika by 2.7 parts of ~.9 parts, sieving with a 100-mesh sieve, crushing 2.7 parts of phoenix tree seed by 2.7 parts of ~.9 parts, sieving with a 100-mesh sieve, drying in the sun, crushing 4.2 parts of abalone fruit seed by 4.2 ~.4 parts, putting the crushed raw materials into a clean container, adding 33 ~ parts of water, stopping heating after boiling for 1 ~.5 hours according to boiling time, discharging minced meat, putting the cooked minced meat into a barrel, mixing a leavening agent of lactobacillus bulgaricus and streptococcus thermophilus according to a ratio of 1:1 at 45 ~ ℃, adding 0.1 ~.4 parts of mixed leavening agent, fermenting for 25 hours at 40 ℃, and fermenting for 40 ~ hours;
(2) stirring 7.4 ~ 7.8.8 parts of winter cherry juice and 8.9 ~ 9.5.5 parts of compound mangosteen juice in a lump machine, adding 95 ~ 100 parts of the fermented paste obtained in the step (1), stirring uniformly for 3 ~ 5 minutes, taking out the mixture, piling the mixture into a pile, covering the pile with PVDC plastic cloth, fermenting for 42 ~ 65 hours at 33 ~ 35 ℃ and 70 ~ 80% relative humidity, after cracks appear on the surface of the pile, crushing the pile, putting 5.1 ~ 5.5 parts of American ginseng and 3.4 ~ 3.6.6 parts of ganoderma spore powder into warm water at 50 ~ 52 ℃ for soaking for 24 ~ 28 minutes at constant temperature, draining, covering an EVOH plastic film, sealing the pile for 19 ~ 21 hours, crushing, putting into a frying pan at 74 ~ 80 ℃ for frying for 6 ~ 7 minutes at constant temperature, naturally cooling at room temperature, and obtaining traditional Chinese medicine clinker for later use;
(3) then 19 parts by weight of ~ parts by weight of smoke tree wax, 4 parts by weight of insect wax, 0.4 part by weight of ~.9 parts by weight of plant latex, 11 ~ parts by weight of polyvinylpyrrolidone, 2 ~ parts by weight of sodium dodecyl benzene sulfonate and 0.4 part by weight of sodium alginate ~ are placed in a reaction vessel provided with a reflux device, the reaction vessel is heated to 60 ~ ℃ to be melted, stirring is started, the rotating speed is controlled to be 1000 ~ rpm and is controlled to be uniform, then 48 ~ parts by weight of distilled water and 0.04 ~.1 part by weight of vitamin C are added, stirring and emulsification is carried out for 40 ~ min, and vinegar is added to ensure that the pH value is 7.2 ~.5, thus obtaining a film-coated emulsion;
(4) cleaning and crushing 3.7 ~ 3.9.9 parts of guava, 4.9 ~ 5.3.3 parts of fresh eucommia leaves, 6.2 ~ 6.8.8 parts of dogwood and 5.9 ~ 6.3.3 parts of coriander, adding 37 ~ 45 parts of water, decocting in an iron pot at 100 ℃ for 1 ~ 2 hours, filtering to obtain filter residue and a first decoction liquid, uniformly mixing the filter residue and 0.38 ~ 0.42.42 part of edible salt, fermenting in a closed manner at 33 ~ 35 ℃ for 30 ~ 32 hours, adding water, decocting, filtering to obtain a second decoction liquid, uniformly mixing the first decoction liquid and the second decoction liquid, decocting for 4 ~ 5 minutes, and spray drying to obtain a traditional Chinese medicine extract;
(5) mixing and stirring 20 ~ parts of the traditional Chinese medicine extract obtained in the step (4), 30 ~ parts of the film-coated emulsion obtained in the step (3) and 33 ~ parts of the clinker obtained in the step (2) uniformly, adding 0.03 ~.05 part of citric acid, 0.05 ~.1 part of thyme powder, 0.04 ~.08 part of calcium citrate and 0.02 ~.1 part of calcium chloride, mixing uniformly, feeding into a 40 ~ ℃ screw film forming machine, passing through a homogenizer, a filter, conveying to a casting die lip, continuously running from the casting die lip to 15 ~ cm away from the die lip at the temperature of 15 ~ ℃ to cool the polytetrafluoroethylene casting support at ~ ℃, carrying out air knife 30-degree angle of 40 ~ mm and gap of 1.6 ~.0 mm, carrying out compressed air of 0.3 ~.38 MPa, volatilizing 24 ~ hours at 35 9640 ℃ to obtain a casting support, cutting into slices, and drying the slices at ~ ℃ to 394% of water content of ~% to form tablets;
(6) sterilizing, packaging, and labeling.
2. The herbal pieces-for-medicine for preventing and treating dental ulcer as claimed in claim 1, wherein said plant latex is a mixture of eucommia latex and Russian dandelion latex, wherein the emulsion has a solid content of 34 ~ 43%, a viscosity of 10 ~ 70 mPa.s, and a centrifugal stability, a storage stability and a dilution stability of grade 1, and the ratio of eucommia and dandelion is 1:1 by weight.
3. The decoction pieces of Chinese herbal medicine for preventing and treating dental ulcer as claimed in claim 1, wherein the compound mangosteen juice is prepared by taking 12 ~ 14 parts by weight of fresh mangosteen flesh, removing kernels and skins, crushing, adding 17.8 parts by weight of 17.8 ~ 18.8.8 parts by weight of jerusalem artichoke juice with the temperature of 49 ~ 51 ℃, grinding, filtering and taking juice to obtain the compound mangosteen juice.
4. The decoction pieces of Chinese medicine for preventing and treating oral ulcer as claimed in claim 1, wherein said berry juice is prepared by taking 23 ~ 24 parts by weight of fresh berries, adding 25 ~ 26 parts by weight of water and sterile water at 54 ~ 56 ℃ for grinding, filtering and getting juice.
5. The traditional Chinese medicine decoction pieces for preventing and treating oral ulcer as claimed in claim 1, wherein the spore powder is wall-broken spore powder of green ganoderma lucidum or black ganoderma lucidum originally produced at east foot of Zhang Guangdong mountain in Changbai mountain, the wall-broken rate is greater than 98%, the ganoderma lucidum spore powder produced in the current year is selected, all the spore powder is stored at-20 ℃ in a refrigeration mode, the ganoderma lucidum spore powder has no peculiar smell and no rot and mildew, the total number of bacterial colonies meets the national standard, the spore powder is selected by spot inspection, the spore powder is plump under a microscope, the abnormal particle is less than 1 ~ 5%, and the impurities of the non-spore powder in the raw materials are less than 1 ~ 3%.
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