CN110584132A - 一种肾脏病特殊医学用途营养配方食品及其制备方法 - Google Patents
一种肾脏病特殊医学用途营养配方食品及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种肾脏病特殊医学用途营养配方食品,由以下重量份的原料组成:9‑12份高生物价蛋白质、9‑14份具有保健功能的油脂、50‑62份碳水化合物、4‑7份膳食纤维、0.9‑2.5份人体必需维生素矿物质、1‑4份药食两用的中药提取物。配方中的原料按照一定顺序和比例混合,加入10倍量蒸馏水溶解,用混合仪搅拌乳化,采用喷雾干燥技术干燥,获得干粉,或者采用湿法喷雾制粒的工艺制备成粉末状颗粒,并灌装成500‑1000g每罐,每100g含有的能量为1892KJ。本发明提供的营养配方食品不仅可作为单一营养来源满足肾病患者的营养需求,还有补肾益精、健脾滋肝、益气补血、利湿消肿及防治肾病的功能。
Description
技术领域
本发明属于肾病营养食品技术领域,尤其涉及一种肾脏病特殊医学用途营养配方食 品及其制备方法。
背景技术
慢性肾脏病(CKD)是由各种原因引起的肾脏组织结构和功能的障碍,包括肾小球过 滤率GFR的正常或不正常的病理损伤、血液或尿液成分异常,及影像学检查异常,或不明原因GFR下降(<60ml/min·1.73m2)超过3个月,都可以称为慢性肾脏病,最近的调 查显示,一般人群中CKD患病率显著不同,各国的患病率从5%到13%不等。在发达国 家,糖尿病肾病、高血压肾小动脉硬化已成为慢性肾脏病的主要原因;在我国,CKD也 有明显增高趋势。根据GFR可以将慢性肾脏病分为5期。CKD的易患因素主要有:年 龄(如老年)、CKD家族史(包括遗传性和非遗传性肾病)、糖尿病、高血压、肥胖- 代谢综合征、高蛋白饮食、高血脂症、高尿酸血症等。随着肾脏功能的慢慢衰竭,可能 出现的并发症营养不良、尿毒症、贫血代谢性酸中毒、心血管疾病、糖尿病、高血压等 等症状。
广泛认为及时和适当的饮食是CKD患者护理的一个重要方面。饮食干预取决于肾脏 疾病的类型和阶段。因此,需要定期评估,营养师监测的膳食处方对患者康复十分重要,合适的营养在减缓肾功能衰退中起重要作用。CKD营养干预的目标包括解决CKD的根 本原因(如糖尿病和高血压);实现和维持最佳营养状况和氮平衡;防止有毒代谢产物 的堆积,从而最大限度地降低尿毒症的风险。营养支持是降低肾病并发症的主要策略。 废物积累和电解质,液体和激素稳态的紊乱都可以通过饮食调整来限制,对于患有CKD 的个体的营养干预,应该降低继发性甲状旁腺功能亢进、恶心、肌肉萎缩、心力衰竭、 高血压、疲劳、呼吸短促、恶心和生活质量差的风险。建立全面的健康饮食模式促进液 体、电解质和矿物质平衡,预防血脂异常、血糖升高、微量营养素缺乏和蛋白质能量营 养不良,保持适当的体重,如磷粘合剂,铁和碳酸氢盐。
目前国内外均提倡采用特殊营养食品,对肾病患者等特定人群进行营养补充和改善。 因此,根据肾病患者的代谢特点和营养需求,选择适宜的食物原料和营养素,制备供肾病患者食用的特殊营养食品,对改善CDK患者的生活质量具有重要意义。
药食同源性食物在我国历史悠久、应用广泛。这类食物不仅可作为食物,为人体提供营养功能,而且还具有很高的药用价值,提供一定的治疗作用。国家卫生部于2002年 颁布了“既是食品又是药品的物品名单(卫法监发[2002]51号)”,为传统中草药在食品中的应用提供的依据。
目前用于肾功能改善的特殊营养食品的补肾补血以及其他肝脏滋补效果不佳,且缺 少强筋健骨以及防治肾病的功能。
发明内容
本发明的目的在于克服上述现有技术的不足之处,而提供一种慢性肾炎非全营养配 方食品,采用一种或几种药食两用的中药提取物精华、优质蛋白质、碳水化合物、油脂及膳食纤维为主要原料,以维生素、矿物质辅料,不仅可作为单一营养来源满足肾病患 者的营养需求,还有补肾益精、健脾滋肝、益气补血、利湿消肿及防治肾病的功能。
为实现上述目的,本发明第一方面提供一种肾脏病特殊医学用途营养配方食品,由 以下重量份的原料组成:9-12份高生物价蛋白质、9-14份具有保健功能的油脂、50-62份碳水化合物、4-7份膳食纤维、0.9-2.5份人体必需维生素矿物质、1-4份药食两用的中 药提取物;所述药食两用的中药原料选自黄芪、党参、白术、茯苓、山茱萸、芡实、淫 羊藿、肉苁蓉、熟地黄、菟丝子、甘草、葛根、五味子中的一种或一种以上。
高生物价蛋白质如乳清蛋白和大豆蛋白,这类蛋白质中的氨基酸利用率高,各种氨 基酸的比率符合人体蛋白质氨基酸的比率,产生代谢废物如氨、尿素等少;容易被人体吸收、消化;优选的,所述高生物价蛋白质为乳清蛋白、大豆蛋白、酪蛋白、白蛋白中 的一种或几种混合而成;
具有保健功能的油脂为脂肪或者脂肪酸,脂肪或脂肪酸是指其含有的脂肪及脂肪酸 除了能够为患者提供足够的能量之外,还能够降血脂和降血压、预防糖尿病、防脑中风和心肌梗塞等功效牡丹籽油富含n-3多不饱和脂肪酸是大脑和脑神经的重要营养成分, 可提高婴幼儿智力发育,预防老年人痴呆症;具有促进细胞再生,抗衰老,活血化瘀, 消炎杀菌,预防心脑血管病,降血脂,防癌,抗过敏等作用,还可以消除色素沉淀,减 少皱纹,使肌肤细腻光洁、富有弹性等等的功效;因此,本发明优选的,所述具有保健 功能的油脂为鱼油及其提取物、大豆油、菜籽油、花生油、玉米油、稻米油、橄榄油、 棕榈油、菜籽油、亚麻籽油、葵花籽油、牡丹籽油、高锌花生油、核桃油、粟米油、火 麻油、山茶油、芥花子油、芝麻油、葡萄籽油、中长链脂肪酸油、没食子油的其中一种 或者几种的混合油。
本发明中添加的维生素和矿物质,是人体所必需的微量元素,其中,优选的,必需矿物质为钙、磷、钾、钠、镁、氯、铁、锌、硒、铜、锰、碘、氟、铬和钼中的一种、 几种或全部混合;必需维生素为维生素A、维生素D、维生素E、维生素K、维生素C、 维生素B、维生素B1、维生素B2、维生素B6、维生素B12、烟酸、叶酸、泛酸、胆碱和 生物素中的一种、几种或全部混合。
对于特殊营养食品,在美国、欧盟等发达国家都有相应的规定和开发应用;而我国GB29922-2013《特殊医学用途配方食品通则》食品安全国家标准中医学食品明确规定:2.1.1医学配方食品:可作为单一营养来源满足目标人群营养需求的特殊医学用途配方食品;2.1.2特定医学配方食品:可作为单一营养来源满足目标人群在特定疾病或医学状况下营养需求的特殊医学用途配方食品。
本发明中的维生素及矿物质按照《特殊医学用途配方食品通则》规定,确定适合于肾脏病患者最佳的配方比例,例如:以每100g为例,具体含量添加如下:维生素A323.6μg、维生素C61.7mg、维生素D3.0μg、维生素B10.7mg、维生素B20.7mg、维生素B60.7mg、 维生素B121.4μg、维生素E8.8mg、烟酸8.4mg、叶酸254.7μg、泛酸3.1mg、生物素18.2μg、 钙267.3mg、镁123.8mg、铁9.3mg、锌6.8mg、铜1.2mg、β-胡萝卜素193.4μg、锰21.mg、 铬31.3μg、硒31.1μg。
优选的,所述膳食纤维是低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖和低聚木糖其中的一种、几种或全部混合。
优选的,所述碳水化合物所述碳水化合物包括单糖、双糖和多糖;如葡萄糖、果糖、半乳糖、乳糖、蔗糖、麦芽糖、L-阿拉伯糖、糊精、淀粉、糖原、多聚果糖中的一种、 几种或者全部混合。食物中的碳水化合物分成两类:人可以吸收利用的有效碳水化合物 如单糖、双糖、多糖和人不能消化的无效碳水化合物,如纤维素,是人体必需的物质; 糖类化合物是一切生物体维持生命活动所需能量的主要来源;它不仅是营养物质,而且 有些还具有特殊的生理活性;例如:肝脏中的肝素有抗凝血作用;血型中的糖与免疫活 性有关;此外,核酸的组成成分中也含有糖类化合物—核糖和脱氧核糖;因此,糖类化 合物对肾脏病患者来说,具有更重要的意义。
优选的,所述药食两用的中药提取物中中药原料包含黄芪、党参、白术、茯苓、山茱萸、芡实、淫羊藿、肉苁蓉、熟地黄、菟丝子、甘草、葛根、五味子中的几种或全部 组合物,将这些药物联合应用,功效产生协同作用,从而能够有效治疗肾病综合征;所 述药食两用的中药原料由以下重量份的原料组成:20-25份黄芪、20-25份党参、13-16 份白术、13-15份茯苓、10-12份山茱萸、9-11份肉苁蓉、10-11份熟地黄、8-10份菟丝 子、8-10份甘草、4-6份葛根、4-6份五味子。
依据中医理论:
黄芪其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿的功能,炙用有补 中益气的功能,治内伤劳倦,脾虚泄泻之症。党参具有补中益气,健脾益肺。用于脾肺 虚弱,气短心悸,食少便溏,与黄芪配伍最好。
白术性温,味甘、苦。归脾经、胃经。功效健脾、益气、燥湿利水、止汗、安胎。 属补虚药下属分类的补气药。用于治脾胃气弱、不思饮食、倦怠少气、虚胀、泄泻、痰 饮、水肿、黄疸、湿痹、小便不利、头晕、自汗、胎气不安等。药理研究有明显且持久 的抗利尿作用,还有解痉、保肝、抗菌等药理作用。还具有促进肠胃蠕动、利胆、抗氧 化、降血糖、抗凝血、抗菌、扩张血管、抑制心脏、镇静等作用。
茯苓既能利水渗湿,又具健脾作用,对于脾虚具有治疗作用;茯苓能养心安神,也具有一定的抗癌、抗肿瘤作用和提高体液免疫功能。
芡实性平,味甘、涩。归脾经、肾经。功效益肾固精,补脾止泻,除湿止带。属收 涩药下属分类的固精缩尿止带药。用治遗精滑精,遗尿尿频,脾虚久泻,白浊,带下。 芡实还可以加强小肠吸收功能,提高尿木糖排泄率,增加血清胡萝卜素浓度;芡实含有 丰富的淀粉,可为人体提供热能,并含有多种维生素和碳物质,保证体内营养所需成分;
山茱萸果入药,为收敛性补血剂及强壮剂;性微温,味酸、涩。归肝经、肾经。功 效补益肝肾,收涩固脱。用于眩晕耳呜,腰膝酸痛,阳痿遗精,遗尿尿频,崩漏带下, 大汗虚脱,内热消渴。药理研究:增强免疫系统功能;抗炎;抗失血性休克;降血糖; 抑制血小板聚集;改善心功能及血流动力学;抗菌;利尿等。
淫羊藿性温,味辛、甘。归肝经、肾经。功效补肾阳、强筋骨、祛风湿。属补虚药 下属分类的补阳药。用治阳痿遗精、筋骨痿软、风湿痹痛、麻木拘挛;更年期高血压。 药理研究:对下丘脑-垂体-性腺轴功能具有调节作用;调节机体免疫功能;对阳虚动物模 型具有“助阳”的作用,可增加冠脉血流量,降低血压等。动物实验表明,有广泛的激素 样作用,有促进性腺功能;水提液可抗衰老与促进物质代谢;淫羊藿多糖和总黄酮有免 疫调节功能;煎剂有强心、降压和增加冠脉流量的作用。
肉苁蓉性温,味甘、咸。归肾经、大肠经。功效补肾阳、益精血、润肠通便。属补 虚药下补阳药。用于腰膝痿软、阳痿、女子不孕、肠燥便秘。药理研究:能增强体液和 细胞免疫功能;具有延缓衰老的作用;具有降压、抗突变等作用。有调整内分泌、促进 代谢及强壮作用。
熟地黄味甘,性温;归肝;肾经;具有补血滋润,益精填髓;属补虚药下分类的补 血药。用于血虚萎黄,心悸怔忡,月经不调,崩漏下血,肝肾阴虚,腰膝酸软,骨蒸潮 热,盗汗遗精,内热消渴,眩晕,耳鸣,须发早白。
菟丝子性平,味辛、甘。归肝经、肾经、脾经。功效补肾益精,养肝明日。属补虚 药下分类的补阳药。用于肾虚腰痛,阳痿,早泄,尿浊,带下,小便频数;胎动不安, 先兆流产;肝肾不足,视物昏花,视力减退。此外,本品还可用于脾虚食少,大便不实。 药理研究:对下丘脑-垂体-性腺有兴奋作用;促进造血;增强免疫功能;防治心肌缺血; 抑制肿瘤发生;抗肝损害等。
甘草可以补脾益气:用于心气虚,心悸怔忡,脉结代,以及脾胃气虚,倦怠乏力等;可以缓急止痛,常与芍药同用,能显著增强治挛急疼痛的疗效。
葛根性凉,味甘、辛。归脾经、胃经。功效解肌退热、生津、透疹、升阳止泻。用 治伤寒、温热头痛项强、烦热消渴、泄泻、痢疾、癍疹不透、高血压、心绞痛、耳聋等。 药理实验表明,葛根具有p-受体阻断剂作用,是心血管作用的基础;具有明显的解热作 用;可收缩或舒张平滑肌;还具有扩张冠状动脉血管和脑血管,增加冠状动脉血流量和 脑血流量,降低心肌耗氧量,增加氧供应,降低血压、降血糖和解除肠管痉挛等作用。
五味子具有敛肺,滋肾,生津,收汗,涩精;可治肺虚喘咳,口干作渴,自汗,盗 汗,劳伤羸瘦,梦遗滑精,久泻久痢。
慢性肾脏病以“虚损”为本,肾藏精气,精气充则五脏六腑气血旺盛,精气虚则五脏不足,故“精气夺则虚”。肾脏劳损,阴阳气血皆以虚损,施治当以补益肾元为要;而肾 元虚损病及五脏,五脏所伤穷必及肾,故调治五脏亦可安肾。脾胃为后天之本,气血生 化之源,脾胃气虚,受纳与健运乏力,脾胃运化不利则湿浊内生。慢性肾脏病基本病机 是本虚标实,在其发展过程中,以脾、肾亏虚为本,湿热、痰浊、瘀血为标;多虚实夹 杂,故治疗时一般应以标本兼顾,且须多考虑治本,宜以补益脾肾为主,兼以利湿消肿。 本发明是根据生命科学和实践应用,结合中医理论,淫羊藿补肾阳、强筋骨、祛风湿; 肉苁蓉具有补肾阳、益精血;菟丝子补肾益精、养肝明日;熟地黄有补血滋润、益精填 髓;山茱萸补益肝肾,收涩固脱;五味子具有敛肺滋肾,生津涩精;芡实滋养强壮、补 中益气、固肾养精;奏补肾固精之功,为君药。黄芪益卫固表、利水消肿,党参补中益 气、健脾益肺;白术健脾益气、燥湿利水,加强益气助运之力;茯苓利水渗湿、健脾安 神,苓术相配,则健脾祛湿之功益著;奏益气健脾、利湿消肿之功,共为臣药。反佐甘 辛而凉葛根,既能解表退热,又能升发脾胃清阳之气而治下利;甘草甘缓和中,调和诸药, 共为佐使。全方标本兼治,共奏补肾益精、健脾滋肝、益气补血、利湿消肿、防治肾病 之功。以适合中老年人的身体的演变过程,并以肠胃、肾脏、泌尿性功能障碍为主攻, 从局部到整体,依补虚,治血理证,可以有效地预防治疗中老年肾盂、肾衰、泌尿、性 功能障碍等疾病。
本发明的另一方面,提供了一种肾脏病特殊医学用途营养配方食品的制备方法,包 括以下步骤:
(1)将药食两用的中药原料组分除杂,粉碎,过80-100目筛,得细粉;加入重量 为原料重量的6-8倍的水进行浸泡1-1.5h,煎煮30-60min,过滤,滤液备用;药渣在加 入重量为原料重量的6-8倍的水进行第二次煎煮30min,过滤,合并两次煎煮液,浓缩干 燥制备成粉状或颗粒状中药提取物;
(2)将步骤(1)所得中药提取物、高生物价蛋白质、具有保健功能的油脂、碳水 化合物、膳食纤维素、人体必需维生素及矿物质按配比混合在一起(根据《特殊医学用 途配方食品通则》确定适合于肾脏病患者较佳的配方比例),加入10倍量蒸馏水溶解, 用混合仪搅拌乳化,然后采用喷雾干燥技术干燥制备成干粉,或者采用湿法喷雾制粒技 术制备成粉末状颗粒,进行包装。例如灌装成500-1000g每罐,其中每100g含有的能量 为1892KJ。
利用上述制备方法制成的营养配方食品,可以根据患者具体病情及需求分早中晚三 餐食用。
本发明的有益效果:
本发明提供了一种慢性肾脏病非全营养食品配方,采用一种或几种药食两用的中药 提取物精华、优质蛋白质、碳水化合物、油脂及膳食纤维为主要原料,以维生素、矿物 质辅料,不仅可作为单一营养来源满足肾病患者的营养需求,还有补肾壮阳、益精补血、 滋补肝肾,强筋健骨、固精缩尿及防治肾病的功能。
具体实施方式
为了能够更清楚地理解本发明的上述目的、特征和优点,下面结合具体实施例对本 发明进行详细描述。需要说明的是,在不冲突的情况下,本申请的实施例及实施例中的特征可以相互组合。
除非另有定义,本文所使用的所有的技术和科学术语与属于本发明的技术领域的技 术人员通常理解的含义相同。本文中在本发明的说明书中所使用的术语只是为了描述具 体的实施例的目的,不是旨在于限制本发明。
实施案例1
一种肾脏病特殊医学用途营养配方食品,由以下重量份的原料组成:10份高生物价 蛋白、14份油脂、62份碳水化合物、6份膳食纤维素、6份药食两用的中药提取物、2 份人体必需维生素及矿物质;
其中,药食两用的中药提取物中中药原料包括:黄芪25份、党参20份、白术16份、茯苓14份、山茱萸12份、肉苁蓉9份、熟地黄10份、菟丝子9份、甘草8份、葛根5 份、五味子5份。
上述营养配方食品制备过程如下:
(1)先将各中药原料组分除杂,粉碎,过80-100目筛,得细粉;加入重量为原料 重量的6-8倍的水进行浸泡1-1.5h,对浸泡液进行煎煮30-60min,过滤,滤液备用;药 渣在加入重量为原料重量的6-8倍的水进行第二次煎煮30min,过滤,合并两次煎煮液, 浓缩干燥制备成粉状或颗粒状中药提取物。
(2)首先将10份高生物价蛋白、14份脂肪(脂肪酸)、62份碳水化合物、6份膳 食纤维素、6份中药提取物、2份人体必需维生素及矿物质混合在一起,加入10倍量蒸 馏水溶解,用混合仪搅拌乳化,采用喷雾干燥技术干燥,获得干粉,进行包装;或者采 用湿法喷雾制粒的工艺制备成粉末状颗粒,并灌装成500/1000g每罐,也可适量加入其 他辅料制备成胶囊、块状等易于携带的食品种类。
实施案例2
一种肾脏病特殊医学用途营养配方食品,由以下重量份的原料组成:12份高生物价 蛋白、15份脂肪(脂肪酸)、63份碳水化合物、4份膳食纤维素、4.5份药食两用的中药 提取物、1.5份人体必需维生素及矿物质;
其中,药食两用的中药提取物中中药原料包括:黄芪20份、党参20份、白术15份、茯苓15份、山茱萸10份、肉苁蓉10份、熟地黄10份、菟丝子10份、甘草10份、葛 根5份、五味子5份。
上述营养配方食品制备过程如下:
(1)先将各中药原料组分除杂,粉碎,过80-100目筛,得细粉;加入重量为原料 重量的6-8倍的水进行浸泡1-1.5h,对浸泡液进行煎煮30-60min,过滤,滤液备用;药 渣在加入重量为原料重量的6-8倍的水进行第二次煎煮30min,过滤,合并两次煎煮液, 浓缩干燥制备成粉状或颗粒状中药提取物。
(2)首先将12份高生物价蛋白、15份脂肪(脂肪酸)、63份碳水化合物、4份膳 食纤维素、4.5份药食两用的中药提取物、1.5份人体必需维生素及矿物质混合在一起, 加入10倍量蒸馏水溶解,用混合仪搅拌乳化,采用喷雾干燥技术干燥,获得干粉,进行 包装;或者采用湿法喷雾制粒的工艺制备成粉末状颗粒,并灌装成500/1000g每罐,也 可适量加入其他辅料制备成胶囊、块状等易于携带的食品种类。
实施案例3
一种肾脏病特殊医学用途营养配方食品,由以下重量份的原料组成:9份高生物价蛋 白、12份脂肪(脂肪酸)、66份碳水化合物、8份膳食纤维素、3.5份药食两用的中药提 取物、1.5份人体必需维生素及矿物质;
其中,药食两用的中药提取物中中药原料包括:黄芪25份、党参25份、白术13份、茯苓13份、山茱萸12份、肉苁蓉11份、熟地黄11份、菟丝子8份、甘草9份、葛根5 份、五味子5份。
上述营养配方食品制备过程如下:
(1)先将各中药原料组分除杂,粉碎,过80-100目筛,得细粉;加入重量为原料 重量的6-8倍的水进行浸泡1-1.5h,对浸泡液进行煎煮30-60min,过滤,滤液备用;药 渣在加入重量为原料重量的6-8倍的水进行第二次煎煮30min,过滤,合并两次煎煮液, 浓缩干燥制备成粉状或颗粒状中药提取物。
(2)首先将9份高生物价蛋白、12份脂肪(脂肪酸)、66份碳水化合物、8份膳食 纤维素、3.5份药食两用的中药提取物、1.5份人体必需维生素及矿物质混合在一起,加 入10倍量蒸馏水溶解,用混合仪搅拌乳化,采用喷雾干燥技术干燥,获得干粉,进行包 装;或者采用湿法喷雾制粒的工艺制备成粉末状颗粒,并灌装成500/1000g每罐,也可 适量加入其他辅料制备成胶囊、块状等易于携带的食品种类。
不同配方食品对模型大鼠慢性肾病的保护作用评价:
将30只雄性SD大鼠在实验动物中心SPF级环境下喂养,12h昼夜循环照明,温 度26℃,湿度50%,自由摄食及饮水,适应性喂养1周后。按随机数字表随机分为5组, 每组6只:正常对照组(正常大鼠,正常饮食);阴性对照组(模型大鼠,正常饮食);阳 性对照组(模型大鼠,广州邦世迪医用食品公司产品“匀浆膳”);样品1组(模型大鼠, 样品1);样品2组(模型大鼠,样品2);其中的样品1和样品2分别为采用实施例1 和2制备而成的营养配方食品。
正常对照组每日基础饲料喂养;造模组每日给予腺嘌呤300mg/kg/d,灌胃10d,第11天起改为250mg/kg/d,连续灌胃11d,共计21d。实验组大鼠尿量大于对照组50%, 另外,检验24h尿蛋白,明显升高,确定造模成功。
造模成后开始给药。正常组及阴性对照组均给予基础饲料喂养,阳性对照组及样品 组按照样品与基础饲料1:1混合喂养,持续喂养2周。给药期间每周检测一次大鼠血糖、体重、24h尿量及尿蛋白量等常规指标。
表1各组大鼠造模前后指标变化
表2.一周后大鼠指标变化
表3.两周后大鼠指标变化
结果如表1所示,显示各模型组大鼠的尿蛋白明显高于造模前,说明造模成功。喂养几周后可以发现阳性对照组及样品组大鼠24小时尿蛋白含量等各项指标均显著改善,说明样品对肾脏具有显著的保护作用。
典型病例:
病例1:
李某,男,54岁,患者因“反复颜面及双下肢水肿2年,加重1周”被诊断为:慢性 肾炎,给予强的松治疗,患者病情反复不愈,在服用本发明的营养食品前,查血压 130/80mmHg,双下肢凹陷性水肿,查尿常规示尿蛋白3+,诊断为慢性肾炎,而服用本 发明实例2制备的颗粒药剂,每次30g,分早中晚三餐食用,一周后患者水肿症状消失。 两个月后复查尿常规示尿蛋白为微量,三个月后复诊复查尿蛋白为阴性,患者一般情况 良好,随诊至今病情稳定。
病例2:
刘某,男,47岁,患者因“头晕不适一周”就诊,查体:血压180/110mmHg,双下肢 凹陷性水肿,查尿常规示尿蛋白3+。眼底检查未见异常。诊断:慢性肾炎,肾性高血压。 而服用本发明实例2制备的颗粒药剂,每次40g,分早中晚三餐食用。一周后患者水肿症 状消失,继续坚持服用三个月后,复查尿常规,结果尿蛋白波动于微量及阴性之间,患 者病情稳定。
最后应说明的是,以上实施例仅用以说明本发明的技术方案而非限制,尽管参照较 佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或等同替换,而不脱离本发明技术方案的精神和范围。
Claims (9)
1.一种肾脏病特殊医学用途营养配方食品,其特征在于:由以下重量份的原料组成:9-12份高生物价蛋白质、9-14份具有保健功能的油脂、50-62份碳水化合物、4-7份膳食纤维、0.9-2.5份人体必需维生素矿物质、1-4份药食两用的中药提取物;所述药食两用的中药原料选自黄芪、党参、白术、茯苓、山茱萸、芡实、淫羊藿、肉苁蓉、熟地黄、菟丝子、甘草、葛根、五味子中的一种或一种以上。
2.根据权利要求1所述的一种肾脏病特殊医学用途营养配方食品,其特征在于:所述高生物价蛋白质为乳清蛋白、大豆蛋白、酪蛋白、白蛋白中的一种或几种混合而成。
3.根据权利要求1所述的一种肾脏病特殊医学用途营养配方食品,其特征在于:所述具有保健功能的油脂为鱼油及其提取物、大豆油、菜籽油、花生油、玉米油、稻米油、橄榄油、棕榈油、菜籽油、亚麻籽油、葵花籽油、牡丹籽油、高锌花生油、核桃油、粟米油、火麻油、山茶油、芥花子油、芝麻油、葡萄籽油、中长链脂肪酸油、没食子油的其中一种或者几种的混合油。
4.根据权利要求1所述的一种肾脏病特殊医学用途营养配方食品,其特征在于:所述矿物质为钙、磷、钾、钠、镁、氯、铁、锌、硒、铜、锰、碘、氟、铬和钼中的一种、几种或全部混合。
5.根据权利要求1所述的一种肾脏病特殊医学用途营养配方食品,其特征在于:所述维生素为维生素A、维生素D、维生素E、维生素K、维生素C、维生素B、维生素B1、维生素B2、维生素B6、维生素B12、烟酸、叶酸、泛酸、胆碱和生物素中的一种、几种或全部混合。
6.根据权利要求1所述的一种肾脏病特殊医学用途营养配方食品,其特征在于:所述膳食纤维是低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖和低聚木糖其中的一种、几种或全部混合。
7.根据权利要求1所述的一种肾脏病特殊医学用途营养配方食品,其特征在于:所述碳水化合物包括单糖、双糖和多糖;如葡萄糖、果糖、半乳糖、乳糖、蔗糖、麦芽糖、L-阿拉伯糖、糊精、淀粉按照一定比例混合。
8.根据权利要求1所述的一种肾脏病特殊医学用途营养配方食品,其特征在于:所述药食两用的中药原料由以下重量份的原料组成:20-25份黄芪、20-25份党参、13-16份白术、13-15份茯苓、10-12份山茱萸、9-11份肉苁蓉、10-11份熟地黄、8-10份菟丝子、8-10份甘草、4-6份葛根、4-6份五味子。
9.根据权利要求1所述的一种肾脏病特殊医学用途营养配方食品的制备方法,其特征在于:包括以下步骤:
(1)将药食两用的中药原料组分除杂,粉碎,过80-100目筛,得细粉;加入重量为原料重量的6-8倍的水进行浸泡1-1.5h,煎煮30-60min,过滤,滤液备用;药渣在加入重量为原料重量的6-8倍的水进行第二次煎煮30min,过滤,合并两次煎煮液,浓缩干燥制备成粉状或颗粒状中药提取物;
(2)将步骤(1)所得中药提取物、高生物价蛋白质、具有保健功能的油脂、碳水化合物、膳食纤维素、人体必需维生素及矿物质按配比混合在一起,加入10倍量蒸馏水溶解,用混合仪搅拌乳化,然后采用喷雾干燥技术干燥制备成干粉,或者采用湿法喷雾制粒技术制备成粉末状颗粒,进行包装。
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Application publication date: 20191220 |