CN110582494A - 碘氟潘的制造方法 - Google Patents

碘氟潘的制造方法 Download PDF

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Publication number
CN110582494A
CN110582494A CN201880027329.3A CN201880027329A CN110582494A CN 110582494 A CN110582494 A CN 110582494A CN 201880027329 A CN201880027329 A CN 201880027329A CN 110582494 A CN110582494 A CN 110582494A
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CN
China
Prior art keywords
radioiodinated
aqueous solution
compound
production method
radioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880027329.3A
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English (en)
Chinese (zh)
Inventor
外山正人
梅原惠美
木野友博
森田武
大畑伸介
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Medical Science Co Ltd
Original Assignee
Japan Medical Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Medical Science Co Ltd filed Critical Japan Medical Science Co Ltd
Publication of CN110582494A publication Critical patent/CN110582494A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880027329.3A 2017-03-17 2018-03-08 碘氟潘的制造方法 Pending CN110582494A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017052700 2017-03-17
JP2017-052700 2017-03-17
PCT/JP2018/008984 WO2018168643A1 (ja) 2017-03-17 2018-03-08 イオフルパンの製造方法

Publications (1)

Publication Number Publication Date
CN110582494A true CN110582494A (zh) 2019-12-17

Family

ID=63522975

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880027329.3A Pending CN110582494A (zh) 2017-03-17 2018-03-08 碘氟潘的制造方法

Country Status (3)

Country Link
JP (1) JP7241013B2 (ja)
CN (1) CN110582494A (ja)
WO (1) WO2018168643A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114487184B (zh) * 2022-01-21 2023-09-22 江苏省原子医学研究所 一种测定2β-甲酯基-3β-(4-氯苯基)托品烷及其有关物质的方法
CN116399984B (zh) * 2023-06-09 2023-08-15 天津辰欣药物研究有限公司 一种利用液相-质谱联用法测定wxtj0262原料药中四丁基碘化铵残留量的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
WO1995001184A1 (en) * 1992-02-25 1995-01-12 Research Biochemicals Limited Partnership An iodinated neuroprobe for mapping monoamine reuptake sites
WO1998057909A1 (en) * 1997-06-16 1998-12-23 Map Medical Technologies Oy Process for the production of radioiodinated neuroreceptor agents
CN102781938A (zh) * 2009-12-17 2012-11-14 通用电气健康护理有限公司 N-单氟烷基莨菪烷的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2579902T2 (sl) * 2010-06-04 2019-10-30 Life Molecular Imaging Sa Postopek za izdelavo amiloidnih beta ligandov, označenih s F-18

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
WO1995001184A1 (en) * 1992-02-25 1995-01-12 Research Biochemicals Limited Partnership An iodinated neuroprobe for mapping monoamine reuptake sites
WO1998057909A1 (en) * 1997-06-16 1998-12-23 Map Medical Technologies Oy Process for the production of radioiodinated neuroreceptor agents
US6365125B1 (en) * 1997-06-16 2002-04-02 Map Medical Technologies Oy Process for the production of radioiodinated neuroreceptor agents
CN102781938A (zh) * 2009-12-17 2012-11-14 通用电气健康护理有限公司 N-单氟烷基莨菪烷的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOHN L.NEUMEYER等: "N-w-Fluoroalkyl Analogs of (lR)-2β-Carbonmethoxy-3β- (4-iodopheny1)-tropane (β-CIT): Radiotracers for Positron Emission Tomography and Single Photon Emission Computed Tomography Imaging of Dopamine Transporters", 《JOURNAL OF MEDICINAL CHEMISTRY》 *

Also Published As

Publication number Publication date
JP7241013B2 (ja) 2023-03-16
JPWO2018168643A1 (ja) 2020-01-16
WO2018168643A1 (ja) 2018-09-20

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