CN110575523A

CN110575523A - yangsheng snow chrysanthemum sleeping water and preparation method thereof

Info

Publication number: CN110575523A
Application number: CN201810586358.5A
Authority: CN
Inventors: 杨明林
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-06-08
Filing date: 2018-06-08
Publication date: 2019-12-17

Abstract

the invention discloses a male semiaquilegia sleeping water and a preparation method thereof, wherein the sleeping water comprises the following components in parts by weight: 3-5 parts of lotus, 3-5 parts of snow chrysanthemum, 5-10 parts of spina date seeds, 3-5 parts of albizia flowers, 3-5 parts of lily, 3-5 parts of medlar, 4-8 parts of mulberry, 3-5 parts of poria cocos, 3-5 parts of dried orange peel and 2-3 parts of ginseng. The invention fully applies the theory of five elements generating and restraining each other, and based on the wood-soil restraining relationship and the wood-fire restraining relationship utilized by the existing nerve-soothing preparation, on the basis of the water-wood restraining relationship, the invention can tonify the kidney to nourish the liver, nourish water and protect the wood, and further tonify the deficiency of liver blood; treating both symptoms and root causes of deficiency-excess inclusion, tonifying deficiency of liver blood, clearing away excess pathogenic heat, and fundamentally treating or improving insomnia caused by liver depression, blood deficiency, fire and spleen qi deficiency; the selected lotus, snow chrysanthemum, medlar, mulberry and the like are both edible and medicinal foods, are safer compared with traditional Chinese medicine preparations, basically have no toxic or side effect on human bodies, and have better mouthfeel.

Description

Yangsheng snow chrysanthemum sleeping water and preparation method thereof

Technical Field

The invention relates to the technical field of composition formulas, in particular to a nerve-soothing preparation, and especially relates to a male-lotus-snow chrysanthemum sleeping water and a preparation method thereof.

Background

Insomnia refers to a subjective experience that a patient does not meet the sleep time and/or quality and affects day-to-day social functions, and the patient has the following clinical manifestations: (1) sleep process disorders such as difficulty in falling asleep, decreased sleep quality, and decreased sleep time; (2) daytime cognitive dysfunction such as memory decline and attention decline; (3) peripheral brain systems such as cardiovascular system and motor system and peripheral vegetative nerve functional disturbance; (4) immune system, endocrine system, and other system symptoms.

The causes of insomnia are multifaceted and often a composite effect of multiple causes. Modern medicine considers that the cause of the insomnia mainly comprises environmental insomnia, psychological behavior disorder, mental diseases, physical diseases, medicament induction and the like; the theory of traditional Chinese medicine considers that the causes of insomnia mainly include external six excesses, internal seven emotions, overeating and deficiency of qi and blood, which are basically consistent with the understanding of modern medicine on the causes of insomnia. The traditional Chinese medicine theory is used for analyzing the insomnia pathology, the insomnia is mainly divided into insomnia caused by yin-yang disharmony, insomnia caused by ying-wei disharmony, insomnia caused by deficiency of qi and blood and insomnia caused by viscera dysfunction, the insomnia treatment mainly aims at coordinating yin and yang and harmonizing ying-wei, aims at tonifying deficiency of viscera and eliminating excess of pathogenic factors, adopts a non-pathogenic factor (pathogenic factors are not obvious) to treat the root according to the specific conditions of a patient, and has a pathogenic factor to treat the root and the root.

The prescriptions for treating insomnia throughout the generations and the existing preparations for treating insomnia are directed at deficiency syndromes such as deficiency of heart-qi, liver-blood, heart-yin and heart-yang, tangible and intangible pathogens, and deficiency-excess complications such as disharmony between heart and kidney, liver depression, obstruction of triple energizer, and disharmony between liver and spleen. Wherein the incoordination between liver and spleen is insomnia caused by liver depression, blood deficiency, fire, and spleen qi deficiency, the traditional treatment formula or preparation is DANZHIXIAOYAO powder, and bupleuri radix is used for dispersing stagnated liver qi and relieving qi stagnation; angelica and white peony root have the functions of enriching blood and nourishing liver; poria, Atractylodis rhizoma, and radix Glycyrrhizae Preparata for invigorating spleen; cortex moutan and fructus Gardeniae clear heat and purge fire. The medicines are used together to play the effects of soothing liver, nourishing blood, strengthening spleen, tonifying qi, clearing heat and purging fire.

in the theory of mutual generation and restriction of five elements in traditional Chinese medicine, there is a mutual relationship between five zang organs.

in the relationship of mutual restriction, the liver qi can remove the stagnation of spleen dampness, which is named as mu ke soil; when the restriction of the liver and spleen is too strong, the liver-qi will transverse to the stomach or pass the spleen, resulting in the syndrome of disharmony between the liver and stomach (or) the liver and spleen, which is called wood-hyperactivity over earth. For therapeutic reasons, the method of soothing liver and calming liver should be used to strengthen the body resistance, while the method of tonifying spleen qi should be used to strengthen the body resistance.

In the relationship of generation, the liver stores blood, the heart governs blood vessels, and the liver has normal functions of storing blood and regulating blood volume, which is helpful for normal exertion of the functions of heart governing blood vessels, namely, the liver wood can be used for treating heart fire, namely, wood can be used for generating fire; when liver blood is deficient, it can not nourish heart, resulting in endogenous deficient heat and malnutrition of heart-mind; for therapeutic principle, tonify blood, nourish heart, clear heat and purge fire should be used.

The prescription or the preparation conforms to the theory of mutual generation and mutual inhibition of five elements in the traditional Chinese medicine, treats both symptoms and root causes, and has certain efficacy on treating insomnia caused by liver depression, blood deficiency, fire transformation and spleen qi deficiency. However, for deficiency of liver blood, the prescription or preparation only uses angelica and white peony root to enrich and nourish the liver, and does not nourish the liver from the mutual relationship of five elements, because the kidney can store essence, the kidney essence can generate liver blood, namely kidney water nourishes liver wood, namely water grows wood, and when the liver blood is deficient, the kidney also needs to be nourished to nourish the liver, namely a water nourishing wood method; most of the prescription or preparation is traditional Chinese medicinal materials, the medicinal properties are strong, and the prescription for recuperating both food and medicine is needed to promote sleep and improve insomnia symptoms caused by liver depression, blood deficiency, fire transformation and spleen qi deficiency.

Disclosure of Invention

The invention provides a sleep water containing Yangsheng, snow chrysanthemum, medlar and mulberry, which fully applies the theory of five elements growing together, tonifies the kidney to nourish the liver, nourishes water and wood, further tonifies liver and blood deficiency and improves insomnia symptoms; and the selected lotus, snow chrysanthemum, medlar, mulberry and the like are both edible and medicinal foods, and compared with traditional Chinese medicine preparations, the traditional Chinese medicine preparation is safer, basically has no toxic or side effect on human bodies, and has better mouthfeel.

The technical scheme adopted for solving the technical problem is as follows:

The sleep water containing the following components in parts by weight: 3-5 parts of lotus, 3-5 parts of snow chrysanthemum, 5-10 parts of spina date seed, 3-5 parts of albizia flower, 3-5 parts of lily, 3-5 parts of medlar, 4-8 parts of mulberry, 3-5 parts of poria cocos, 3-5 parts of dried orange peel and 2-3 parts of ginseng.

Preferably, the weight ratio is as follows: 4 parts of wild lotus, 3 parts of snow chrysanthemum, 7 parts of spina date seed, 4 parts of albizia flower, 5 parts of lily, 5 parts of medlar, 7 parts of mulberry, 4 parts of poria cocos, 3 parts of dried orange peel and 3 parts of ginseng.

In the formula of the sleep water, the yangshi, the poria cocos and the dried orange peel have the effects of strengthening the spleen and stomach, and the ginseng has the effects of strengthening the spleen and replenishing qi; the combination of yang lotus, tuckahoe, dried orange peel and ginseng strengthens spleen and qi and harmonizes stomach to tonify spleen qi deficiency. Wherein:

(1) Yangsheng is a perennial herb of Zingiber of Zingiberaceae, the whole plant has unique fragrance, the tender bud and stem fruit of the Yangsheng are delicious, and the Yangshen is a rare dietary fiber which contains abundant vitamins, a plurality of amino acids and a seventh nutrient element and is called as mountain delicacy; it is warm in nature and pungent in flavor, and enters lung, spleen and stomach meridians, and its branches, leaves, roots, flowers and fruits can clear swelling, remove toxicity, relieve cough and asthma, resolve food stagnation and invigorate stomach. Compared with ginger, the yang lotus has the advantages of mild drug property, stomach harmonization, adverse qi lowering without over-temperature, excellent medicinal value, delicious taste, rich nutrition and higher edible value.

Furthermore, the tender bud of the lotus can be used as a prescription, so that the stomach and adverse qi can be harmonized more gently.

(2) Poria has mild nature and sweet and bland taste, and can enter spleen, kidney, heart and lung channels, has the effect of invigorating spleen, can be used with pericarpium Citri Tangerinae and rhizoma Pinelliae for nourishing heart and tranquilizing mind, and can be used for treating uneasiness, cardiopalmus, insomnia, etc. According to modern pharmacological analysis, the poria cocos contains polysaccharide and triterpenoid, and has health-care effects of resisting tumors, enhancing immunity and the like.

(3) The dried orange peel is warm in nature, bitter and pungent in taste, enters spleen and lung channels, can be used for regulating the middle warmer and harmonizing stomach, harmonizing stomach and lowering adverse qi, and regulating qi and tonifying spleen, and according to modern pharmacological analysis, the effects of the dried orange peel on regulating the stomach and lowering adverse qi, and regulating qi and tonifying spleen are mainly derived from volatile oil compounds contained in the dried orange peel, and the volatile oil can alleviate and stimulate the digestive tract.

(4) Ginseng is warm, sweet and bitter, and has effects of invigorating spleen, heart and kidney channels, invigorating primordial qi, invigorating spleen, benefiting lung, tranquilizing mind and improving intelligence.

Furthermore, the ginseng is red ginseng, and the processing of the ginseng into the red ginseng is more suitable for strengthening the spleen and replenishing qi.

The yang lotus, the poria cocos, the dried orange peel and the ginseng are both used as medicine and food, and the yang lotus is mainly used as food material and has mild effect.

In the formula of the sleep water, the spina date seeds nourish heart and liver and calm nerves, the lily has the effects of clearing away heart-fire and calming nerves, and the albizia flower has the effects of resolving depression and calming nerves; the spina date seed, the lily and the albizia flower are combined to soothe liver, relieve depression, nourish heart and calm nerves. Wherein:

(1) The spina date seed has mild nature, sweet and sour taste, nourishes the liver, enters liver and heart channels, calms the heart and soothes the nerves. The semen Ziziphi Spinosae contains heavy fatty oil and protein, and contains sterol, triterpenes, semen Ziziphi Spinosae saponin, and vitamin C; according to the pharmacological research of the present generation, the medicine has the functions of tranquilizing, hypnotizing, easing pain and resisting convulsion.

Furthermore, the spina date seeds are fried spina date seeds, and the efficacy of the fried spina date seeds is exerted to the maximum extent.

(2) Lily is cold in nature and sweet in taste, and enters heart and lung meridians, and can clear heart and tranquilize mind, nourish yin and moisten lung. Can be used for treating insomnia, dreaminess, absentmindedness, and dry cough due to yin deficiency.

(3) Albizia flower is neutral in nature and sweet in taste, and has the effects of nourishing heart and liver channel, resolving stagnation, tranquilizing mind, regulating qi-flowing and promoting appetite. The albizzia julibrissin contains quercetin, is used for treating melancholy insomnia and uneasiness, and is a good product for treating neurasthenia.

In the formula of the sleep water, the medlar and the mulberry have the effects of nourishing kidney, liver and blood. Wherein:

(1) fructus Lycii has mild nature and sweet taste, and can enter liver and kidney meridians, and has effects of nourishing liver and kidney, and can be used for treating consumptive disease and essence deficiency, and blood deficiency and withered and yellow. The Chinese wolfberry polysaccharide, the most main active component in Chinese wolfberry, has the effects of promoting immunity, resisting fatigue, protecting liver and the like.

Furthermore, the medlar is black medlar, and compared with red medlar, the medlar has better effect of nourishing liver and kidney.

(2) Mulberry is cold in nature and sweet in taste, and has the effects of tonifying liver and kidney, nourishing yin and enriching blood.

in the formula of the sleep water, the snow chrysanthemum is slightly cold in nature, sweet and bitter in taste, enters liver and lung channels, can clear heat and purge fire and strengthen spleen and stomach, and has milder effects of clearing heat and purging fire compared with common chrysanthemum; and modern pharmacological research shows that the snow chrysanthemum contains various flavonoids, various mineral elements necessary for human bodies, more than 20 amino acids, dozens of aromatic compounds, abundant organic acids, vitamins, enzymes, polysaccharides and the like, has pharmacological effects exceeding those of common scented tea, and can be drunk as a health-care chrysanthemum tea drink for a long time.

The sleep liquid is used for treating insomnia caused by liver depression, blood deficiency, fire transformation and spleen qi deficiency, and is prepared from bupleurum, spina date seed, lily and albizia flower for soothing liver-qi stagnation, nourishing heart and soothing nerves; YANGHUO, Poria, pericarpium Citri Tangerinae, and Ginseng radix have effects in invigorating spleen, invigorating qi, and regulating stomach function; the medlar and the mulberry have the effects of nourishing kidney, liver and blood; the snow chrysanthemum can clear heat and purge fire, and strengthen spleen and stomach. The medicines are combined to play the effects of soothing liver and relieving depression, strengthening spleen and tonifying qi and harmonizing stomach, nourishing kidney and liver, enriching blood and soothing nerves, and clearing heat and purging fire.

The formula of the sleep water fully utilizes the five-element generation and restriction theory of the traditional Chinese medicine, wherein the theory comprises the liver (wood), spleen (earth) restriction relation, the liver (wood), heart (fire) restriction relation and the kidney (water), liver (wood) restriction relation, and each organ is functionally supported by other organs so that the organ can not be damaged; but also restrict other zang organs so that it does not become excessive; if the qi of the main body is excessive, there will be restriction of qi of other zang organs; the deficiency of qi of the main zang organs is accompanied by the deficiency of qi of other zang organs to nourish them. Through the generation and restriction relationship, the viscera are tightly connected into a whole, thereby maintaining the coordination and unification of the internal environment of the human body, treating both symptoms and root causes of deficiency and excess, tonifying deficiency of liver blood, clearing away excess pathogenic factors of heat fire, and fundamentally treating or improving insomnia caused by liver depression, blood deficiency, fire transformation and spleen qi deficiency. In addition, most of the components of the sleep water formula are edible and medicinal foods, so that the sleep water is safer compared with a traditional Chinese medicine preparation and basically has no toxic or side effect on a human body; the ingredients only have the flavor of yang lotus and ginseng which are slightly bitter, and the rest ingredients are sweet, sweet and sour, sweet and salty, so the sleeping water has better sensory experience; the components also have the health-care function of the food material.

the invention also provides a preparation method of the senecio cineraria sleeping water, which comprises the following specific steps:

(1) Moistening the drugs: soaking the raw materials in 6-10 times of water for 0.2-0.6 h;

(2) Water extraction: extracting with 5-8 times of water for 1-2 h, filtering, collecting filtrate, continuously extracting with 3-6 times of water for 0.5-1.5 h, filtering, and collecting filtrate;

(3) Concentration: mixing the two extracted liquids together, concentrating the mixture until the total weight percentage of the dry medicinal materials is 65-75%, and filtering the mixture;

(4) preparation: adding auxiliary materials into the concentrated extracting solution;

(5) homogenizing, and centrifuging to remove impurities;

(6) Sterilizing to obtain the final product.

Further, the filtration of step (3) adopts ultrafiltration or membrane filtration.

Detailed Description

the technical solution of the present invention will be described in detail with reference to the following examples. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.

Example 1

The sleep water containing the following components in parts by weight: 3 parts of yangsheng rhizome, 4 parts of snow chrysanthemum, 8 parts of raw wild jujube kernel, 4 parts of albizia flower, 4 parts of lily, 5 parts of red wolfberry, 5 parts of mulberry, 3 parts of poria cocos, 5 parts of dried orange peel and 3 parts of sun-dried ginseng.

Example 2

The sleep water containing the following components in parts by weight: 4 parts of tender buds of lotus, 5 parts of snow chrysanthemum, 6 parts of raw wild jujube kernels, 3 parts of albizia flowers, 4 parts of lily, 5 parts of red wolfberry, 7 parts of mulberry, 4 parts of poria cocos, 4 parts of dried orange peel and 3 parts of sun-dried ginseng.

Example 3

The sleep water containing the following components in parts by weight: 4 parts of tender buds of lotus, 3 parts of snow chrysanthemum, 7 parts of fried spina date seeds, 4 parts of albizia flowers, 5 parts of lily, 5 parts of red wolfberry, 7 parts of mulberry, 4 parts of poria cocos, 3 parts of dried orange peel and 2.5 parts of sun-dried ginseng.

Example 4

The sleep water containing the following components in parts by weight: 5 parts of tender buds of lotus, 4 parts of snow chrysanthemum, 9 parts of fried spina date seeds, 3 parts of albizia flowers, 5 parts of lily, 3 parts of lycium ruthenicum, 6 parts of mulberry, 5 parts of poria cocos, 4 parts of dried orange peel and 3 parts of sun-dried ginseng.

example 5

The sleep water containing the following components in parts by weight: 3 parts of tender buds of lotus, 5 parts of snow chrysanthemum, 8 parts of fried spina date seeds, 4 parts of albizia flowers, 3 parts of lily, 3 parts of black wolfberry, 8 parts of mulberry, 4 parts of poria cocos, 4 parts of dried orange peel and 2 parts of red ginseng.

Example 6

A preparation method of a sleep water containing Asarum ageratoides and Helichrysum cinerariifolium comprises the following specific steps:

(1) Moistening the drugs: soaking the raw materials in 6 times of water for 0.5 h;

(2) water extraction: extracting with 7 times of water for 1.5 hr, filtering, collecting filtrate, extracting with 5 times of water for 1.5 hr, filtering, and collecting filtrate;

(3) concentration: mixing the two extractive solutions, concentrating to 65% of the total weight of the dry medicinal materials, and vacuum filtering;

(5) homogenizing, and centrifuging to remove impurities;

(6) sterilizing to obtain the final product.

example 7

(1) Moistening the drugs: soaking the raw materials in 9 times of water for 0.4 h;

(2) Water extraction: extracting with 5 times of water for 2 hr, filtering, collecting filtrate, extracting with 3 times of water for 1.5 hr, filtering, and collecting filtrate;

(3) Concentration: mixing the two extractive solutions, concentrating to 75 wt% of the dry medicinal materials, and ultrafiltering;

(5) Homogenizing, and centrifuging to remove impurities;

(6) Sterilizing to obtain the final product.

example 8

(1) moistening the drugs: soaking the raw materials in 8 times of water for 0.5 h;

(2) Water extraction: extracting with 6 times of water for 1.5 hr, filtering, collecting filtrate, extracting with 5 times of water for 1 hr, filtering, and collecting filtrate;

(3) Concentration: mixing the two extractive solutions, concentrating to 70% of the total weight of the dry medicinal materials, and membrane filtering;

(5) homogenizing, and centrifuging to remove impurities;

(6) sterilizing to obtain the final product.

nerve soothing efficacy test

(1) 56 KM mice, weighing 18-22 g, half male and half female, were randomly divided into blank groups, examples 1-5, and 8 mice per group. In examples 1-5, the sleep water with the crude drug amount of 16g/kg is administrated in a stomach irrigation mode, the diazepam water solution with the dose of 0.002g/kg is administrated in an intraperitoneal injection way after the administration of the 1% sodium carboxymethylcellulose solution for 20min in a positive control group, the 1% sodium carboxymethylcellulose solution is administrated in a blank group, the administration volume is 0.025ml/g (body weight), the administration is carried out for 1 time every day, and the administration lasts for 7 days; pentobarbital sodium is injected into the abdominal cavity to affect sleep, and the number and time of sleep are observed. The experimental result shows that the sleep water has the effect of improving abnormal sleep of the experimental mouse caused by the sodium pentobarbital, and the sleep water of each embodiment can obviously prolong the sleep time of the experimental mouse (table 1), which shows that the sleep water has the nerve soothing effect.

(2) 56 KM mice, weighing 18-22 g, half male and half female, were randomly assigned to the blank group, the positive control group, examples 1-5, and 8 mice per group. Before the gavage, the mice are put into a 40cm/24cm/30cm organic glass box to adapt for 3min, and then the spontaneous activity time and the lifting times of forelimbs of the mice within 2min are respectively measured to be used as normal activity reaction indexes. In examples 1-5, the crude drug amount of 16g/kg of sleep water was administered by gavage, the positive control group was administered with a 1% sodium carboxymethylcellulose solution for 20min, and then administered with a 0.002g/kg dose of diazepam aqueous solution by intraperitoneal injection, and the blank group was administered with a 1% sodium carboxymethylcellulose solution, and the administration volume was 0.025ml/g (body weight) 1 time per day for 7 consecutive days. The above indexes are retested 30min and 60min after the last gastric lavage. The experimental result shows that the sleep water has the function of improving and regulating the spontaneous activity of the mice, and the sleep water of each embodiment can obviously reduce the number of times of forelimb erection and the spontaneous activity time of the experimental mice (table 2), which shows that the sleep water has the function of soothing the nerves.

TABLE 1 influence of sleep water on sleep time of laboratory mice

note: p <0.05, P <0.01, P <0.001, data are shown as mean ± standard deviation, compared to blank group.

TABLE 2 influence of sleep water on spontaneous Activity of laboratory mice

Claims

1. The sleep water containing the ageratum procumbens is characterized by comprising the following raw materials in parts by weight: 3-5 parts of lotus, 3-5 parts of snow chrysanthemum, 5-10 parts of spina date seeds, 3-5 parts of albizia flowers, 3-5 parts of lily, 3-5 parts of medlar, 4-8 parts of mulberry, 3-5 parts of poria cocos, 3-5 parts of dried orange peel and 2-3 parts of ginseng.

2. The senecio cineraria sleeping water as claimed in claim 1, wherein the raw materials comprise, by weight: 4 parts of wild lotus, 3 parts of snow chrysanthemum, 7 parts of spina date seed, 4 parts of albizia flower, 5 parts of lily, 5 parts of medlar, 7 parts of mulberry, 4 parts of poria cocos, 3 parts of dried orange peel and 3 parts of ginseng.

3. the senecio cineraria sleeping water as claimed in claim 1, wherein: the lotus is tender shoot of the lotus.

4. The senecio cineraria sleeping water as claimed in claim 1, wherein: the semen Ziziphi Spinosae is parched semen Ziziphi Spinosae.

5. the senecio cineraria sleeping water as claimed in claim 1, wherein: the fructus Lycii is Lycium ruthenicum Murr.

6. The senecio cineraria sleeping water as claimed in claim 5, wherein: the Ginseng radix is Ginseng radix Rubri.

7. the preparation method of the senecio cineraria sleeping water as claimed in any one of claims 1 to 6, which is characterized by comprising the following steps:

(5) Homogenizing, and centrifuging to remove impurities;

(6) Sterilizing to obtain the final product.

8. the preparation method of the senecio cineraria sleeping water according to claim 7, which is characterized in that: the filtration mode of the step (3) is ultrafiltration or membrane filtration.