CN110575413A - Preparation method of pepper extract and application of pepper extract in cosmetics - Google Patents
Preparation method of pepper extract and application of pepper extract in cosmetics Download PDFInfo
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- CN110575413A CN110575413A CN201911014609.3A CN201911014609A CN110575413A CN 110575413 A CN110575413 A CN 110575413A CN 201911014609 A CN201911014609 A CN 201911014609A CN 110575413 A CN110575413 A CN 110575413A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
the invention relates to a preparation method of a pepper extract and application thereof in cosmetics, which comprises the following steps: d1 preparing pricklyash peel powder, D2 steam distilling to remove volatile oil, D3 separating the cooking liquor, D4 alcohol extracting, D5 removing numb substance, D6 preparing alcohol extract B, D7 preparing pricklyash peel extract, the powdered pricklyash peel extract and paste pricklyash peel extract prepared by the above method can be applied to cosmetics to provide the effects of anti-allergy, relieving itching, antibiosis, antiphlogosis and spot lightening. The pepper extract prepared by the method removes volatile oil and numb-taste substances, removes anesthetic action and irritant substances of the extract, and retains antibacterial and antiallergic substances of the pepper extract.
Description
Technical Field
The invention relates to the technical field of plant cosmetics, in particular to a preparation method of a pepper extract and application of the pepper extract in cosmetics.
Background
The zanthoxylum bungeanum is a spice plant of zanthoxylum of Rutaceae, contains volatile oil, numb substances, alkaloid, protein, lignin, unsaturated fatty acid and other bioactive components, has various pharmacological actions of resisting bacteria and diminishing inflammation, easing pain, calming, stopping bleeding, resisting arteriosclerosis, resisting blood coagulation, reducing blood fat, expelling ascaris and the like, can improve the immunity of organisms in the aspects of resisting bacteria, viruses, tumors and the like, and has higher research and utilization values as one of traditional Chinese medicinal materials along with the rapid development of the traditional Chinese medicine and pharmacy, and the attention of various countries in the world on research, development and utilization and the like of the traditional Chinese medicinal materials.
According to researches, different extraction methods can influence the components and the content in the extract, wherein the volatile oil mainly comprises olefins, alcohols, aldehydes, ketones, esters, epoxy compounds, aromatic hydrocarbons and the like, the medicinal effects mainly comprise anesthesia, bacteriostasis, cancer resistance, disinsection, platelet aggregation resistance and the like, and the anesthesia effect of 20% of UI hair oil is almost the same as the local anesthesia effect of 5% of procaine; the numb-taste substances are mainly chain unsaturated fatty acid amides, a part of the numb-taste substances are acid amides connected with aromatic rings, the representative substance is sanshool, and the numb-taste substances have very strong irritation and have the functions of anesthesia, analgesia, bacteriostasis, disinsection, wind dispelling, dampness removing and the like; the alkaloid compound has various remarkable physiological effects, and mainly has the effects of reaching one platelet, having cytotoxic activity, inhibiting DNA isomerase and selectively inhibiting bacteria; the pricklyash seed kernel oil is rich in unsaturated fatty acid, and can effectively regulate blood fat, prevent lipid peroxidation, improve blood rheology and the like.
The alcohol extract of the pricklyash peel has stronger antioxidation, has certain defense and treatment effects on senile skin spots, senile dementia and various senile cardiovascular and cerebrovascular diseases caused by lipofuscin deposition, but contains more volatile oil substances and numb substances, has large stimulation effect on skin anesthesia, has strong pungent smell, and has larger harm when the crude alcohol extract of the pricklyash peel is directly applied to cosmetics.
disclosure of Invention
In order to overcome the defects, the invention aims to provide a preparation method of a pepper extract and application of the pepper extract in cosmetics.
The technical scheme adopted by the invention for solving the technical problems is as follows: a preparation method of a pepper extract comprises the following steps:
d1 preparation of pepper powder: selecting clean and disease-free dry pepper seeds with peel, crushing, and sieving by a sieve of 80-100 meshes;
D2 steam distillation to remove volatile oil: adding fructus Zanthoxyli powder into a steam distillation extractor, soaking in deionized water at a ratio of 1-3g/mL at normal temperature for 1-2h, heating to boil, performing steam distillation for 2-4h, distilling to collect distillate, and collecting the distillate;
D3 separation of cooking liquor: solid-liquid separation of the cooking liquor to obtain water extract A and residue A;
d4 alcohol extraction: mixing the residue A with 100% wt ethanol solution with a material-liquid ratio of 1-3g/mL, extracting by leaching, percolating, decocting, reflux extracting, and continuous extracting, and separating solid and liquid to obtain ethanol extractive solution A and residue B;
D5 removal of numb substances: adding petroleum ether 8-10 times the amount of the ethanol extract A, performing reverse extraction, standing for 12-24h, and filtering to obtain petroleum ether extract and pungent substance solid;
d6 recovering petroleum ether to obtain alcoholic extract B: removing petroleum ether in the petroleum ether extracting solution by rotary evaporation, and recovering the petroleum ether for later use to obtain an alcohol extracting solution B;
d7 preparation of pepper extract: distilling the water extractive solution A under reduced pressure, removing water to obtain amorphous powdered fructus Zanthoxyli extract A, distilling the alcohol extractive solution B under reduced pressure, removing ethanol, and concentrating to obtain pasty fructus Zanthoxyli extract B.
Specifically, the solid-liquid separation process adopts 8000r/min centrifugation for 10min, and the residue A or B is removed through filtering with 200-mesh and 400-mesh filter cloth in sequence.
specifically, the water extract A is subjected to deproteinization treatment and then is subjected to reduced pressure distillation, the deproteinization process comprises the steps of carrying out reduced pressure concentration to 3/10 of the original volume, adding sevage reagent (the volume ratio of chloroform to n-butanol is 5: 1) into the concentrated solution, adding 1/2 of the concentrated solution, fully stirring, standing for layering, removing protein, repeating the operation for at least 3 times, and collecting the upper solution.
specifically, before reduced pressure distillation, the alcohol extract B is decolorized by using activated carbon to remove pigments in the pure extract B.
The application of the pricklyash peel extract in cosmetics provides the effects of resisting allergy, relieving itching, resisting bacteria, diminishing inflammation and lightening spots by applying the powdery pricklyash peel extract and the pasty pricklyash peel extract prepared by the method to the cosmetics.
specifically, the powdery pepper extract and the pasty pepper extract are mixed and applied to cosmetics.
specifically, the powdered pepper extract: the pasty pepper extract is 1: (1-50).
The invention has the following beneficial effects: the pepper extract prepared by the method removes volatile oil and numb-taste substances, removes anesthetic action and irritant substances of the extract, and retains antibacterial and antiallergic substances of the pepper extract.
Detailed Description
The present invention will now be described in further detail.
Example 1
a preparation method of a pepper extract comprises the following steps:
d1 preparation of pepper powder: selecting clean and disease-free dry pepper seeds with peel, crushing, and sieving by a sieve of 80-100 meshes;
D2 steam distillation to remove volatile oil: weighing 1000g of pepper powder, adding into a steam distillation extractor, adding 1L of deionized water, soaking at normal temperature for 2h, heating to boil, carrying out steam distillation for 2h, distilling to collect distillate, and leaving the distillate to be the cooking liquor;
d3 separation of cooking liquor: solid-liquid separation of the cooking liquor to obtain water extract A and residue A;
d4 alcohol extraction: mixing the residue A with 100% wt ethanol solution with a material-liquid ratio of 1g/mL, extracting by an extraction method, and carrying out solid-liquid separation to obtain an alcohol extract A and a residue B;
d5 removal of numb substances: adding 8 times of petroleum ether into the alcohol extract A, carrying out reverse extraction, standing for 16h, and filtering to obtain a petroleum ether extract and a spicy substance solid;
d6 recovering petroleum ether to obtain alcoholic extract B: removing petroleum ether in the petroleum ether extracting solution by rotary evaporation, and recovering the petroleum ether for later use to obtain an alcohol extracting solution B;
D7 preparation of pepper extract: performing deproteinization treatment on the water extract A, then performing reduced pressure distillation, wherein the deproteinization process comprises the steps of performing reduced pressure concentration to 3/10 of the original volume, adding sevage reagent (chloroform: n-butanol volume ratio is 5: 1) into the concentrated solution, fully stirring the concentrated solution with 1/2 of the concentrated solution, standing for layering, removing protein, repeating the operation for at least 3 times, collecting the upper layer solution, performing reduced pressure distillation on the concentrated water extract A, drying the concentrated water extract A by using anhydrous sodium sulfate, and removing water to obtain 1.26g of amorphous powdery pepper extract A;
and (3) decoloring the alcohol extract B by using active carbon before reduced pressure distillation, removing pigments in the pure extract B, and carrying out reduced pressure distillation on the alcohol extract B, removing ethanol and concentrating to obtain 110.28g of pasty pepper extract B.
specifically, the solid-liquid separation process adopts 8000r/min centrifugation for 10min, and the residue A or B is removed through filtering with 200-mesh and 400-mesh filter cloth in sequence.
example 2
A preparation method of a pepper extract comprises the following steps:
d1 preparation of pepper powder: selecting clean and disease-free dry pepper seeds with peel, crushing, and sieving by a sieve of 80-100 meshes;
d2 steam distillation to remove volatile oil: weighing 1000g of pepper powder, adding into a steam distillation extractor, adding 350mL of deionized water, soaking at normal temperature for 2h, heating to boil, carrying out steam distillation for 2h, distilling to collect distillate, and leaving the distillate to be the cooking liquid;
D3 separation of cooking liquor: solid-liquid separation of the cooking liquor to obtain water extract A and residue A;
d4 alcohol extraction: mixing the residue A with 100% wt ethanol solution with a material-liquid ratio of 2g/mL, extracting by an extraction method, and carrying out solid-liquid separation to obtain an alcohol extract A and a residue B;
D5 removal of numb substances: adding 9 times of petroleum ether into the alcohol extract A, carrying out reverse extraction, standing for 20h, and filtering to obtain petroleum ether extract and pungent substance solids;
D6 recovering petroleum ether to obtain alcoholic extract B: removing petroleum ether in the petroleum ether extracting solution by rotary evaporation, and recovering the petroleum ether for later use to obtain an alcohol extracting solution B;
D7 preparation of pepper extract: performing deproteinization treatment on the water extract A, then performing reduced pressure distillation, wherein the deproteinization process comprises the steps of performing reduced pressure concentration to 3/10 of the original volume, adding sevage reagent (chloroform: n-butanol volume ratio is 5: 1) into the concentrated solution, fully stirring the concentrated solution with 1/2 of the concentrated solution, standing for layering, removing protein, repeating the operation for at least 3 times, collecting the upper layer solution, performing reduced pressure distillation on the concentrated water extract A, drying the concentrated water extract A by using anhydrous sodium sulfate, and removing water to obtain 1.07g of amorphous powdery pepper extract A;
and before reduced pressure distillation, decoloring the alcohol extract B by using active carbon, removing pigments in the pure extract B, carrying out reduced pressure distillation on the alcohol extract B, removing ethanol, and concentrating to obtain 112.13g of pasty pepper extract B.
specifically, the solid-liquid separation process adopts 8000r/min centrifugation for 10min, and the residue A or B is removed through filtering with 200-mesh and 400-mesh filter cloth in sequence.
example 3
a preparation method of a pepper extract comprises the following steps:
d1 preparation of pepper powder: selecting clean and disease-free dry pepper seeds with peel, crushing, and sieving by a sieve of 80-100 meshes;
D2 steam distillation to remove volatile oil: weighing 1000g of pepper powder, adding into a steam distillation extractor, adding 500mL of deionized water, soaking at normal temperature for 1.5h, heating to boil, carrying out steam distillation for 1.5h, distilling and collecting distillate, and keeping a cooking solution;
D3 separation of cooking liquor: solid-liquid separation of the cooking liquor to obtain water extract A and residue A;
d4 alcohol extraction: mixing the residue A with 100% wt ethanol solution with a material-liquid ratio of 3g/mL, extracting by an extraction method, and carrying out solid-liquid separation to obtain an alcohol extract A and a residue B;
D5 removal of numb substances: adding 10 times of petroleum ether into the alcohol extract A, carrying out reverse extraction, standing for 24h, and filtering to obtain a petroleum ether extract and a spicy substance solid;
D6 recovering petroleum ether to obtain alcoholic extract B: removing petroleum ether in the petroleum ether extracting solution by rotary evaporation, and recovering the petroleum ether for later use to obtain an alcohol extracting solution B;
d7 preparation of pepper extract: performing deproteinization treatment on the water extract A, then performing reduced pressure distillation, wherein the deproteinization process comprises the steps of performing reduced pressure concentration to 3/10 of the original volume, adding sevage reagent (chloroform: n-butanol volume ratio is 5: 1) into the concentrated solution, fully stirring the concentrated solution with 1/2 of the concentrated solution, standing for layering, removing protein, repeating the operation for at least 3 times, collecting the upper layer solution, performing reduced pressure distillation on the concentrated water extract A, drying the concentrated water extract A by using anhydrous sodium sulfate, and removing water to obtain 1.21g of amorphous powdery pepper extract A;
And (3) decoloring the alcohol extract B by using active carbon before reduced pressure distillation, removing pigments in the pure extract B, carrying out reduced pressure distillation on the alcohol extract B, removing ethanol, and concentrating to obtain 108.24g of pasty pepper extract B.
specifically, the solid-liquid separation process adopts 8000r/min centrifugation for 10min, and the residue A or B is removed through filtering with 200-mesh and 400-mesh filter cloth in sequence.
Example 4
A preparation method of a pepper extract comprises the following steps:
D1 preparation of pepper powder: selecting clean and disease-free dry pepper seeds with peel, crushing, and sieving by a sieve of 80-100 meshes;
d2 steam distillation to remove volatile oil: weighing 1000g of pepper powder, adding into a steam distillation extractor, adding 800mL of deionized water, soaking at normal temperature for 1h, heating to boil, carrying out steam distillation for 1h, distilling to collect distillate, and leaving the distillate to be the cooking liquid;
d3 separation of cooking liquor: solid-liquid separation of the cooking liquor to obtain water extract A and residue A;
d4 alcohol extraction: mixing the residue A with 100% wt ethanol solution with a material-liquid ratio of 2g/mL, extracting by an extraction method, and carrying out solid-liquid separation to obtain an alcohol extract A and a residue B;
d5 removal of numb substances: adding 9 times of petroleum ether into the alcohol extract A, carrying out reverse extraction, standing for 12h, and filtering to obtain petroleum ether extract and pungent substance solid;
d6 recovering petroleum ether to obtain alcoholic extract B: removing petroleum ether in the petroleum ether extracting solution by rotary evaporation, and recovering the petroleum ether for later use to obtain an alcohol extracting solution B;
d7 preparation of pepper extract: performing deproteinization treatment on the water extract A, then performing reduced pressure distillation, wherein the deproteinization process comprises the steps of performing reduced pressure concentration to 3/10 of the original volume, adding sevage reagent (chloroform: n-butanol volume ratio is 5: 1) into the concentrated solution, fully stirring the concentrated solution with 1/2 of the concentrated solution, standing for layering, removing protein, repeating the operation for at least 3 times, collecting the upper layer solution, performing reduced pressure distillation on the concentrated water extract A, drying the concentrated water extract A by using anhydrous sodium sulfate, and removing water to obtain 0.97g of amorphous powdery pepper extract A;
And (3) decoloring the alcohol extract B by using active carbon before reduced pressure distillation, removing pigments in the pure extract B, carrying out reduced pressure distillation on the alcohol extract B, removing ethanol, and concentrating to obtain 102.13g of pasty pepper extract B.
Specifically, the solid-liquid separation process adopts 8000r/min centrifugation for 10min, and the residue A or B is removed through filtering with 200-mesh and 400-mesh filter cloth in sequence.
The beneficial effects of the present application are further illustrated by the following tests:
Dissolving fructus Zanthoxyli extract A in deionized water to obtain aqueous solution containing fructus Zanthoxyli extract A0.01%, 0.05%, 0.1%, 0.15%, and 0.2%, and dissolving fructus Zanthoxyli extract B in 1, 2-propylene glycol solution to obtain propylene glycol solution containing fructus Zanthoxyli extract B0.01%, 0.05%, 0.1%, 0.15%, and 0.2%, wherein the concentration of propylene glycol is 10%.
1. Irritation test (corneal irritation method)
Taking white rabbits, dripping into left eyes of aqueous solution A and propylene glycol solution B of the pepper extract with different concentrations, taking corresponding aqueous solution and propylene glycol solution as reference groups, dripping into right eyes, wherein the dripping amount is 1 drop, and the results are shown in tables 1 and 2:
experiments show that the pepper extract A has no local irritation symptom to the eye cornea of the white rabbit, and the pepper extract B has no local irritation symptom to the eye cornea of the white rabbit at low concentration (0.01-0.15%), and has some irritation symptoms at high concentration.
2. antibacterial test
The minimum inhibitory concentration of the pepper extract A and the pepper extract B to the microorganisms and the comparison of the inhibitory concentration of ethylparaben to the microorganisms are shown in the table 3:
The tested medicine has the effect of inhibiting the growth and development of 4 pathogenic bacteria under a series of concentration gradient conditions, so that the pepper extract A and the pepper extract B can achieve good antibacterial effect.
3. Skin test of white rabbits
Shearing hair at the left and right sides of the back of 15 white rabbits with a diameter of 4-5cm, exposing the back skin sufficiently, and performing UVB (300 mJ/cm)2) Irradiating the white rabbits once a day for 3 days continuously, dividing the skin on the back of the successfully molded white rabbits into 3 groups, wherein each group comprises 5 white rabbits, the left side of the first group is dripped with 2mL of a 10% pepper extract A aqueous solution, the right side of the first group is dripped with 2mL of deionized water, the left side of the second group is dripped with 2mL of a 10% pepper extract B propylene glycol solution, the right side of the second group is dripped with 2mL of a propylene glycol solution, the left side of the third group is dripped with 2mL of a 2% pepper extract A and 2mL of a 8% pepper extract B propylene glycol,the right propylene glycol solution is 2mL, the skin condition is observed after 12h, the skin condition is observed after the propylene glycol solution is continuously smeared for 15 days, the skin condition is observed, and the results are shown in a table 5 in a table 4 which is a scoring standard of the skin damage condition of a UVB irradiated area on the back.
As can be seen from table 5, the mixture of zanthoxylum bungeanum extract a, zanthoxylum bungeanum extract B and zanthoxylum bungeanum extract A, B can significantly reduce skin damage, and the mixture of zanthoxylum bungeanum extract A, B has a synergistic effect, so that the effect of reducing skin damage is better.
the present invention is not limited to the above embodiments, and any structural changes made under the teaching of the present invention shall fall within the protection scope of the present invention, which is similar or similar to the technical solutions of the present invention.
the techniques, shapes, and configurations not described in detail in the present invention are all known techniques.
Claims (7)
1. a preparation method of a pepper extract is characterized by comprising the following steps: the method comprises the following steps:
D1 preparation of pepper powder: selecting clean and disease-free dry pepper seeds with peels;
d2 steam distillation to remove volatile oil: adding fructus Zanthoxyli powder into a steam distillation extractor, soaking in deionized water at a ratio of 1-3g/mL at normal temperature for 1-2h, heating to boil, performing steam distillation for 2-4h, distilling to collect distillate, and collecting the distillate;
D3 separation of cooking liquor: solid-liquid separation of the cooking liquor to obtain water extract A and residue A;
d4 alcohol extraction: mixing the residue A with 100% wt ethanol solution with a material-liquid ratio of 1-3g/mL, extracting by leaching, percolating, decocting, reflux extracting, and continuous extracting, and separating solid and liquid to obtain ethanol extractive solution A and residue B;
d5 removal of numb substances: adding petroleum ether 8-10 times the amount of the ethanol extract A, performing reverse extraction, standing for 12-24h, and filtering to obtain petroleum ether extract and pungent substance solid;
d6 recovering petroleum ether to obtain alcoholic extract B: removing petroleum ether in the petroleum ether extracting solution by rotary evaporation, and recovering the petroleum ether for later use to obtain an alcohol extracting solution B;
d7 preparation of pepper extract: distilling the water extractive solution A under reduced pressure, removing water to obtain amorphous powdered fructus Zanthoxyli extract A, distilling the alcohol extractive solution B under reduced pressure, removing ethanol, and concentrating to obtain pasty fructus Zanthoxyli extract B.
2. The method for preparing the pepper extract as claimed in claim 1, wherein: the solid-liquid separation process adopts 8000r/min centrifugation for 10min, and the residue A or B is removed by filtering through 200-mesh and 400-mesh filter cloth in sequence.
3. The method for preparing the pepper extract as claimed in claim 1, wherein: and (3) performing deproteinization treatment on the water extract A, then performing reduced pressure distillation, wherein the deproteinization process comprises the steps of concentrating under reduced pressure to 3/10 of the original volume, adding sevage reagent (the volume ratio of chloroform to n-butanol is 5: 1) into the concentrated solution, adding 1/2 of the concentrated solution, fully stirring, standing for layering, removing protein, repeating the operation for at least 3 times, and collecting the upper solution.
4. the method for preparing the pepper extract as claimed in claim 1,2 or 3, wherein: and before reduced pressure distillation, decoloring the alcohol extract B by using active carbon to remove pigments in the alcohol extract B.
5. the application of the pepper extract in cosmetics is characterized in that: the powdered pricklyash peel extract obtained by removing pricklyash peel oil and water extraction and the pasty pricklyash peel extract obtained by alcohol extraction and removing numb-taste substances are applied to cosmetics to provide the effects of resisting allergy, relieving itching, resisting bacteria, diminishing inflammation and lightening spots.
6. The use of the pepper extract as claimed in claim 5 in cosmetics, characterized in that: the powdery pepper extract and the pasty pepper extract are mixed and applied to cosmetics.
7. The use of the pepper extract according to claim 6 in cosmetics, characterized in that: the powdered pepper extract: the pasty pepper extract is 1: (1-50).
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| CN114468345A (en) * | 2021-12-28 | 2022-05-13 | 四川三联新材料有限公司 | Electronic cigarette liquid with pepper flavor and preparation method thereof |
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