CN102198169A - Alcohol-relieving and liver-protecting product made of rosemary, root of kudzu vine and lily and process - Google Patents
Alcohol-relieving and liver-protecting product made of rosemary, root of kudzu vine and lily and process Download PDFInfo
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- CN102198169A CN102198169A CN 201010132426 CN201010132426A CN102198169A CN 102198169 A CN102198169 A CN 102198169A CN 201010132426 CN201010132426 CN 201010132426 CN 201010132426 A CN201010132426 A CN 201010132426A CN 102198169 A CN102198169 A CN 102198169A
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Abstract
The invention relates to a pure natural alcohol-relieving and liver-protecting product and a preparation method thereof. The alcohol-relieving and liver-protecting product is prepared from rosemary liposoluble extract containing 20 to 40 percent of carnosic acid and effective ingredients extracted from root of kudzu vine and lily, and by ultralow-temperature extraction by a modern biological technique and by mixing. The product uses the antioxidant, antihepatitis, liver-protecting and alcohol-relieving capacities of rosemary liposoluble extract, the body fluid secretion promoting and thirsty-quenching effects of root of root of kudzu vine, and the yin-tonifying, lung-nourishing, hearfire-clearing and nerve-soothing effects of lily and can improve the activity of enzyme in liver; and thus, the product can conduct the functions of reliving alcohol, protecting liver, soothing the liver, regulating qi, promoting secretion of body fluid, quenching thirsty, clearing heat and fire, clearing hearfire and soothing nerves to quickly eliminate the symptoms of dizziness, headache, drowsiness, fatigue and the like, to effectively repair damaged liver cells and to inhibit the damage of alcohol to the liver. The product is made by the active ingredients extracted from pure natural plants and therefore is free from toxic and side effects and is an alcohol-relieving and liver-protecting product with remarkable effect.
Description
Technical field:
The invention belongs to the pure natural relieving alcoholism and protecting the liver product that derives from plant material, particularly a kind ofly can relieve the effect of alcohol, protect the liver, hepatoprotective and stabilize liver-fire, accelerate a kind of relieving alcoholism and protecting the liver product that excessive consumption of alcohol person recovers clear-headed consciousness and preparation method thereof.
Background technology:
Long-term excessive consumption of alcohol can cause major injury to human liver and cardiovascular system.The result of study of World Health Organization (WHO) shows: alcohol consumption is one of the most serious worldwide problem that causes the human health infringement, and ethanol is second killer who is only second to the mankind of Nicotiana tabacum L..This product is to be primary raw material with the pure natural plant Herba Rosmarini Officinalis, be aided with Radix Puerariae, Bulbus Lilii, can reach fundamentally improve body immunity, comprehensively regulate and improve liver operation and fast decomposing alcohol and vivotoxin, stabilize liver-fire, thereby play protect the liver, the pure natural of liver-protecting function relieves the effect of alcohol, liver-protecting product.
Herba Rosmarini Officinalis oxidation resistance have anti-aging effects, the Chinese medicine voluminous dictionary: Herba Rosmarini Officinalis has strong function.Anti-hepatitis and hepatoprotective effect and the ability of relieving the effect of alcohol.Enzyme falls, the turbid descending effect is remarkable, the fine selection of treatment fatty liver alcoholic liver, prevention liver cirrhosis.
Rosemary antioxidant is in animal and plant fat, rich oil food and meat product, has the effect that prevention and delay are become sour or prolonged storage life, and the toxic and side effects of synthetized oxidation preventive agent and the weakness that high temperature adds thermal decomposition have thoroughly been avoided, the fried test of toxicological experiment and high temperature shows for 240 ℃, safe, efficient, heat-resisting, characteristics such as antioxidant effect is good, wide spectrum that rosemary antioxidant has, LD50 is the 20g/kg body weight.
Modern pharmacological research proves: contained diterpene phenols composition in the Herba Rosmarini Officinalis, have tangible antioxidation, antitumor, anti AIDS virus, anophelifuge and other multiple activation of microorganism, except that using, be expected to develop medicines such as the antitumor that becomes high-efficiency low-toxicity, anti-AIDS, anophelifuge as antioxidant.
Current relieving alcoholism and protecting the liver series products technological deficiency:
Be generally simple pulverizing, but not extraction of substance, dose is big, and bioavailability is low, and the time is long, weak effect.
Summary of the invention:
The present invention adopts ultrasonic adverse current and membrance separation (molecular sieve) technical method, in the bright branch and leaf of Herba Rosmarini Officinalis, add 30～85% and use ethanol, the solid-liquid ratio is 1: 10～1: 30, extract 15～75 ℃ of temperature, 30 minutes extraction times, super countercurrent extraction Herba Rosmarini Officinalis fat-soluble (carnosic acid is representative) antioxidant has reduced the conversion of carnosic acid to carnosol under lower temperature; Add 80～85% edible ethanols in the Radix Puerariae, the solid-liquid ratio is 1: 15, extracts 65 ℃ of temperature, 45～60 minutes extraction times, super countercurrent extraction total flavones under lower temperature.Add 45～65% edible ethanols in the Bulbus Lilii, the solid-liquid ratio is 1: 15, extracts 65 ℃ of temperature, 45～60 minutes extraction times.
The strong cavitation effect that ultrasound wave produces forms many little holes in the medium, several thousand atmospheric pressure of these little hole closed generations of moment impel plant cell tissue's breaking cellular wall, quicken stripping, the diffusion of effective ingredient.
Membrane separation technique can separate under the room temperature in molecular range and concentrate, and this process is a kind of physical process, the variation of phase need not take place and add auxiliary agent, according to the difference (or being called molecular cut off) in its aperture, film can be divided into micro-filtration membrane, ultrafilter membrane, the sharp reverse osmosis membrane of NF membrane; Chlorophyll is the major impurity composition of plant amedica extract, and molecular weight is bigger, adopts membrance separation to remove effectively, and the efficient in operation under the room temperature prevents the conversion of carnosic acid.
Overall this invented technology is simple, energy consumption is low, production efficiency increases substantially, because overall process is only used edible ethanol, so the exhausted deleterious vehicle substance of noresidue of extract, thereby prevented the existence of harmful thing in the leaching process and, guaranteed 100% pure natural property the pollution of environment.
1, the Herba Rosmarini Officinalis raw material directly adopts bright leaf or bright branch and leaf, be cut into section with bright leaf or with the bright branch and leaf of Herba Rosmarini Officinalis greater than 0.25cm, use ultrasonic countercurrent extraction, extraction solvent is 30～85% edible ethanols, the solid-liquid ratio is 1: 10～1: 30, extract 15～65 ℃ of temperature, 30 minutes extraction times, (membrane aperture is at 10nm～50nm) filter, and filtrate refilters and the sodium filter through rolled film, obtains holding back of different molecular weight through tubular membrane or ceramic membrane for extracting solution, the non-permeate of Herba Rosmarini Officinalis is evaporated to and precipitation occurs or do not have the ethanol flavor, solid-liquid separation, the solid content A that obtains, spray drying obtains Herba Rosmarini Officinalis fat-soluble antioxidant (carnosic acid content 20～40%).
2, powder of Radix Puerariae is broken into coarse powder, extraction solvent is 80～85% edible ethanols, the solid-liquid ratio is 1: 15, extract 65 ℃ of temperature, 45～60 minutes extraction times, (membrane aperture is at 10nm～50nm) filter through tubular membrane or ceramic membrane for extracting solution, filtrate is filtered through sodium, obtain the different compositions of holding back, non-permeate is evaporated to and precipitation occurs or do not have the ethanol flavor, and spray drying obtains Radix Puerariae and extracts (general flavone content is greater than 40%)
3, Bulbus Lilii powder is broken into coarse powder, extraction solvent is 45～65% edible ethanols, the solid-liquid ratio is 1: 15, extract 65 ℃ of temperature, 45～60 minutes extraction times, (membrane aperture is at 10nm～50nm) filter through tubular membrane or ceramic membrane for extracting solution, filtrate is filtered through sodium, obtain the different compositions of holding back, non-permeate is evaporated to and precipitation occurs or do not have the ethanol flavor, and spray drying gets Bulbus Lilii extract.
Case study on implementation 1
(1) the bright leaf of Herba Rosmarini Officinalis is 100 kilograms, is cut into the section that is about 2.5c m, and ultrasonic counter-current extraction, extraction solvent are 65% ethanol, extract 40 ℃ of temperature, solid-liquid ratio 1: 25, extracting solution centrifugalize.
(2) with 50nm aperture membrane filtration, filtrate is through 50000 molecular weight and 10000 molecular weight, again to 500 molecular weight, do not see through liquid and be evaporated to alcohol-free flavor, solid-liquid separation, the appropriate amount of deionized water washing, resulting liquid is deposited standby in addition, the solid content spray drying obtains carnosic acid content and is 3.5 kilograms of 20～40% Herba Rosmarini Officinalis fat-soluble antioxidants (crude product).
(3) be dissolved in the liposoluble extract that obtains in the step (3) in the soybean oil and make soft capsule, carry out plastic-aluminum bubble-cap pressing plate then and handle, the packing warehouse-in.
Case study on implementation 2
(1) the bright branch and leaf of Herba Rosmarini Officinalis are picked, and after the cut-out, produce 20～40% Herba Rosmarini Officinalis liposoluble extract by step (1) (2) in " case study on implementation 1 ".
(2) Radix Puerariae directly is ground into coarse powder, and ultrasonic counter-current extraction, extraction solvent are 85% edible ethanol, and the solid-liquid ratio is 1: 15, extracts 65 ℃ of temperature, 50 minutes extraction times, extracting solution centrifugalize.Extracting solution filters through tubular membrane or ceramic membrane (membrane aperture is at 30nm), and filtrate is evaporated to and precipitation occurs or do not have the ethanol flavor, solid-liquid separation, and spray drying obtains solid content, detects Radix Puerariae total flavones greater than 40%.
(3) extract that step (1) (2) is obtained stirs by 7: 3 usefulness mixers, is made into hard capsule preparation, carries out plastic-aluminum bubble-cap pressing plate then and handles, the packing warehouse-in.
Case study on implementation 3
(1) the bright branch and leaf of Herba Rosmarini Officinalis are picked, and after the cut-out, produce 20～40% Herba Rosmarini Officinalis liposoluble extract by step (1) (2) in " case study on implementation 1 ".
(2) Radix Puerariae directly is ground into coarse powder, produces general flavone content greater than 40% Radix Puerariae extract by the step (2) in " case study on implementation 2 ".
(3) the Bulbus Lilii raw material directly is ground into coarse powder, uses ultrasonic countercurrent extraction, and extraction solvent is 60% edible ethanol, and the solid-liquid ratio is 1: 15, extracts 65 ℃ of temperature, 50 minutes extraction times.Extracting solution filters through tubular membrane or ceramic membrane (membrane aperture is at 30nm), and filtrate decompression concentrates, spray drying obtains Bulbus Lilii extract.
(4) extract that step (1) (2) (3) is obtained stirs by 7: 2: 1 usefulness mixers, mixes an amount of amylum pregelatinisatum and makes soft material, is pressed into the label of 0.25g, carries out coating, is packaged into finished product then.
Claims (10)
1. fill a prescription and component ratio
(1) the Herba Rosmarini Officinalis liposoluble extract 100%;
(2) Herba Rosmarini Officinalis liposoluble extract 20～80%, Radix Puerariae extract 20～80%;
(3) Herba Rosmarini Officinalis liposoluble extract 20～80%, Radix Puerariae extract 20～80%, Bulbus Lilii extract 10%.
2. manufacturing process
(1) Herba Rosmarini Officinalis liposoluble constituent extraction process:
(a) the Herba Rosmarini Officinalis raw material directly adopts bright leaf or bright branch and leaf, is cut into section greater than 0.25cm with the bright leaf of Herba Rosmarini Officinalis or with the bright branch and leaf of Herba Rosmarini Officinalis;
(b), to use ultrasonic countercurrent extraction, extraction solvent be 30～85% edible ethanols, the solid-liquid ratio is 1: 10～1: 30, extracts 15～75 ℃ of temperature, 30 minutes extraction times;
(c), (membrane aperture is at 10nm～50nm) filter, and filtrate refilters and the sodium filter through rolled film, obtains holding back of different molecular weight through tubular membrane or ceramic membrane for extracting solution;
(d), non-permeate is evaporated to and precipitation occurs or do not have the ethanol flavor, solid-liquid separation obtains solid content;
(e), the spray-dried Herba Rosmarini Officinalis fat-soluble antioxidant that obtains of solid content, carnosic acid content 20～40%;
(2) Radix Puerariae extraction process
(a) the Radix Puerariae raw material directly is ground into coarse powder;
(b), to use ultrasonic countercurrent extraction, extraction solvent be 80～85% edible ethanols, the solid-liquid ratio is 1: 15, extracts 65 ℃ of temperature, 45～60 minutes extraction times;
(c), extracting solution filters through tubular membrane or ceramic membrane (membrane aperture is at 30nm), filtrate refilters and the sodium filter through rolled film, obtains holding back of different molecular weight;
(d), non-permeate is evaporated to and precipitation occurs or do not have the ethanol flavor, solid-liquid separation, drying obtains solid content, detects Radix Puerariae total flavones greater than 40%;
(3) Bulbus Lilii extraction process
(a) the Bulbus Lilii raw material directly is ground into coarse powder;
(b) use ultrasonic countercurrent extraction, extraction solvent is 45～65% edible ethanols, and the solid-liquid ratio is 1: 15, extracts 65 ℃ of temperature, 45～60 minutes extraction times;
(c) extracting solution filters through tubular membrane or ceramic membrane (membrane aperture is at 30nm), and filtrate decompression concentrates, spray drying;
(4),, be made into tablet, hard capsule, software capsule according to the prescription ratio with the said extracted thing.
3. according to the prescription and the prescription ratio of claims 1.
4. (a) bright leaf and bright branch and leaf are cut into section greater than 0.25cm according to (1) of claims 2.
5. according to (1) of claims 2 (b) ultrasonic countercurrent extraction method and alcohol concentration 30～85%, extract liquid measure by strengthening, reverse flow technique obtains the concentration difference of bigger Herba Rosmarini Officinalis with extracting solution, reduces Herba Rosmarini Officinalis extraction time, thereby reduces the carnosol that is converted into of carnosic acid.
According to (1) of claims 2 (c) membrance separation concentrate and separation method.
7. according to (1) spray drying process (e) of claims 2.
8. according to (2) membrane separating method and relevant parameter (c) of claims 2.
9. according to (3) membrane separating method and relevant parameter (c) of claims 2.
10. according to the those set forth of (4) of claims 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010132426 CN102198169A (en) | 2010-03-26 | 2010-03-26 | Alcohol-relieving and liver-protecting product made of rosemary, root of kudzu vine and lily and process |
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| CN 201010132426 CN102198169A (en) | 2010-03-26 | 2010-03-26 | Alcohol-relieving and liver-protecting product made of rosemary, root of kudzu vine and lily and process |
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| CN102198169A true CN102198169A (en) | 2011-09-28 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102948750A (en) * | 2012-11-23 | 2013-03-06 | 乔德京 | Stranded radix puerariae pseudo-ginseng lilium brownii capsule |
| CN103875848A (en) * | 2014-02-26 | 2014-06-25 | 湖南农业大学 | Herbal Fu tea capable of alleviating hangover and protecting liver |
| CN107827738A (en) * | 2017-10-27 | 2018-03-23 | 湖南鑫利生物科技有限公司 | A kind of method that carnosic acid is separated from Rosmarinus officinalis extract |
| CN110237155A (en) * | 2019-07-31 | 2019-09-17 | 王鹏 | One kind sober up patch and preparation method thereof |
| CN117860813A (en) * | 2024-03-13 | 2024-04-12 | 云南邦纳科技有限公司 | Composition with liver protection function and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1371732A (en) * | 2002-02-28 | 2002-10-02 | 傅强 | Beverage for relieving alcoholism |
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2010
- 2010-03-26 CN CN 201010132426 patent/CN102198169A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1371732A (en) * | 2002-02-28 | 2002-10-02 | 傅强 | Beverage for relieving alcoholism |
Non-Patent Citations (3)
| Title |
|---|
| 《国外医药 植物药分册》 20070228 王雪超等 绒毛迷迭香醇提物对硫代乙酰胺诱导的大鼠肝硬化的干保护作用 第79页 1-10 第22卷, 第2期 * |
| 《彝族药材现代研究》 20090430 云南省楚雄彝族自治州食品药品监督管理局，昆明医学院 迷迭香 云南科技出版社 第277-290页 1-10 , * |
| 《食品研究与开发》 20070131 肖香等 迷迭香水溶性和脂溶性抗氧化剂的分离 第189页左栏"2 实验方法"项下 1，3 第28卷, 第1期 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102948750A (en) * | 2012-11-23 | 2013-03-06 | 乔德京 | Stranded radix puerariae pseudo-ginseng lilium brownii capsule |
| CN103875848A (en) * | 2014-02-26 | 2014-06-25 | 湖南农业大学 | Herbal Fu tea capable of alleviating hangover and protecting liver |
| CN107827738A (en) * | 2017-10-27 | 2018-03-23 | 湖南鑫利生物科技有限公司 | A kind of method that carnosic acid is separated from Rosmarinus officinalis extract |
| CN110237155A (en) * | 2019-07-31 | 2019-09-17 | 王鹏 | One kind sober up patch and preparation method thereof |
| CN117860813A (en) * | 2024-03-13 | 2024-04-12 | 云南邦纳科技有限公司 | Composition with liver protection function and preparation method and application thereof |
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Application publication date: 20110928 |