CN110573617A - 细菌甘露聚糖酶 - Google Patents
细菌甘露聚糖酶 Download PDFInfo
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Abstract
本发明涉及新的甘露聚糖酶、包含甘露聚糖酶的组合物、制备甘露聚糖酶的方法、以及使用甘露聚糖酶降解或改性含甘露聚糖的材料的方法。
Description
技术领域
本发明涉及细菌甘露聚糖酶。甘露聚糖酶可用于需要降解或改性甘露聚糖的工业应用中,如洗衣和清洁应用、饲料、食品、纸浆和石油工业中。本发明还提供了有用的甘露聚糖酶、编码这些酶的多核苷酸、酶组合物以及它们的制备和使用方法。
背景技术
甘露聚糖是在很多植物中都存在的含有甘露糖的多糖。甘露聚糖在水性环境中不易溶解,且其物理化学性质导致粘性耗散。此外,甘露聚糖的水结合能力高。所有这些特性在一些行业(包括酿造、烘焙、动物营养以及洗衣和清洁应用)中引起问题。
在植物性饮食中存在不同的β-甘露聚糖,取决于它们的量和性质,它们可以损害营养物消化、微生物定植和生长行为。甘露聚糖的酶促降解使高水溶性的甘露聚糖的消化物粘度降低,并导致甘露寡糖的生成,甘露寡糖可能会形成豆科植物中存在的不溶于水的线性甘露聚糖。甘露聚糖酶可增加所有单胃动物的平均日增重、饲料效率、重量均匀度和存活率。
对于动物饲料应用,比如吃谷物日粮的单胃动物的饲料,甘露聚糖是肠内容物粘度的一个贡献因素,因此它对饲料消化率和动物生长速率产生不利影响。对于反刍动物,甘露聚糖代表了纤维摄入的重要组成部分,甘露聚糖的更完全消化会利于饲料转化效率提高。
对于洗衣和清洁应用,包含甘露聚糖酶的酶组合物可用于降解甘露聚糖。然而,提供在不同的储存和使用条件下稳定同时仍显示出良好的甘露聚糖降解活性的甘露聚糖酶是有难度的。
本发明的目的在于提供在不同工业加工中应用时表现出甘露聚糖酶活性的新酶、以及用于甘露聚糖降解或改性的酶组合物。
发明内容
根据本发明的第一方面,提供了一种酶组合物,其包含至少一种甘露聚糖酶,所述甘露聚糖酶具有的氨基酸序列与SEQ ID NO:16(Man7)具有至少70%的序列同一性,与SEQID NO:12(Man6)具有至少93%的序列同一性,和/或与SEQ ID NO:20(Man14)具有至少79%的序列同一性。
根据本发明的另一方面,提供了一种酶组合物,其包含至少一种甘露聚糖酶,所述甘露聚糖酶的核心区具有的氨基酸序列与Man7SEQ ID NO:16的氨基酸27-331具有至少79%的序列同一性,与Man6SEQ ID NO:12的氨基酸35-324具有至少95%的序列同一性,和/或与Man14SEQ ID NO:20的氨基酸17-314具有至少85%的序列同一性。
在一个实施方式中,所述至少一种甘露聚糖酶具有如上定义的核心区。
该酶组合物的优势在于在洗涤剂和制剂中具有良好的稳定性和甘露聚糖酶活性。它也适用于需要甘露聚糖降解或改性的各种工业应用。本发明的酶组合物的甘露聚糖酶适合用于在各种化学环境中降解或改性含甘露聚糖的材料。
如实施例所证明的,根据本发明的酶组合物中包含的甘露聚糖酶具有允许在重组宿主细胞中生产的结构和性质,使其在用于工业应用的酶组合物中有用武之地。Man6、Man7和Man14共有的共同结构元件是GH5结构域。另一个共有的结构元件是:Man6和Man7之间有60%的序列同一性,Man6和Man14之间有57%的序列同一性,Man7和Man14之间有69%的序列同一性。另一个共有的结构特征是核心区。这些结构元件是本发明的甘露聚糖酶的特征所在。
根据第二方面,提供了一种包含遗传元件的重组宿主细胞,所述遗传元件允许生成至少一种重组多肽,所述重组多肽具有甘露聚糖酶活性且
与SEQ ID NO:16的氨基酸序列具有至少70%的序列同一性,
与SEQ ID NO:12的氨基酸序列具有至少93%的序列同一性,和/或
与SEQ ID NO:20的氨基酸序列具有至少79%的序列同一性,
其中所述宿主细胞选自下组:
真菌细胞,
丝状真菌细胞,其选自子囊菌(Ascomycota)门、盘菌(Pezizomycotina)亚门,优选地选自粪壳菌(Sordariomycetes)纲、肉座菌(Hypocreomycetidae)亚纲、肉座菌(Hypocreales)目、小囊菌(Microascales)目的成员、以及曲霉(Aspergillus)、金孢霉(Chrysosporium)、毁丝霉(Myceliophthora)和腐质霉(Humicola);
更优选地选自:肉座菌(Hypocreacea)科、丛赤壳(Nectriaceae)科、麦角菌(Clavicipitaceae)科、小囊菌(Microascaceae)科、木霉属(Trichoderma,其为肉座菌(Hypocrea)属的无性型)、镰刀菌(Fusarium)属、赤霉(Gibberella)属、丛赤壳(Nectria)属、穗霉(Stachybotrys)属、麦角菌(Claviceps)属、绿僵菌(Metarhizium)属、稻曲菌(Villosiclava)属、蛇形虫草(Ophiocordyceps)属、头孢菌(Cephalosporium)属和丝孢菌(Scedosporium)属;
更优选地选自:里氏木霉(Trichoderma reesei,红褐肉座菌(Hypocreajecorina))、桔绿木霉(Trichoderma citrinoviridae)、长枝木霉(Trichodermalongibrachiatum)、绿木霉(Trichoderma virens)、哈茨木霉(Trichoderma harzianum)、棘孢木霉(Trichoderma asperellum)、深绿木霉(Trichoderma atroviridae)、拟里氏木霉(Trichoderma parareesei)、尖孢镰刀菌(Fusarium oxysporum)、禾谷镰刀菌(Fusariumgramineanum)、小麦冠腐病菌(Fusarium pseudograminearum)、镰孢霉(Fusariumvenenatum)、藤仓赤霉菌(Gibberella fujikuroi)、串珠状赤霉(Gibberellamoniliformis)、玉蜀黍赤霉(Gibberella zeaea)、红球丛赤壳菌(Nectria haematococca,血赤壳菌(Haematonectria haematococca))、黑葡萄穗霉(Stachybotrys chartarum)、穗霉(Stachybotrys chlorohalonata)、紫色麦角菌(Claviceps purpurea)、蝗绿僵菌(Metarhizium acridum)、金龟子绿僵菌(Metarhizium anisopliae)、稻曲病菌(Villosiclava virens)、冬虫夏草菌(Ophiocordyceps sinensis)、顶头孢霉(Acremoniumchrysogenum,产黄头孢霉(Cephalosporium chrysogenum))、尖端赛多孢子菌(Scedosporium apiospermum)、黑曲霉(Aspergillus niger)、泡盛曲霉(Aspergillusawamori)、米曲霉(Aspergillus oryzae)、金孢子菌(Chrysosporium lucknowense)、嗜热毁丝霉(Myceliophthora thermophila)、腐质霉(Humicola nigrescens)和灰腐质霉(Humicola grisea);
细菌细胞,优选为革兰氏阳性杆菌如枯草芽孢杆菌(Bacilli subtilis)、地衣芽孢杆菌(Bacilli licheniformis)、巨大芽孢杆菌(Bacilli megaterium)、解淀粉芽孢杆菌(Bacilli amyloliquefaciens)、短小芽孢杆菌(Bacilli pumilus),革兰氏阴性细菌比如大肠杆菌(Escherichia coli),放线菌比如链霉菌(Streptomyces sp.);以及
酵母,如酿酒酵母(Saccharomyces cerevisiae)、毕赤酵母(Pichia pastoris)、解脂耶罗维亚酵母(Yarrowia lipolytica);
最优选为里氏木霉或芽孢杆菌。
重组宿主细胞可用于制备甘露聚糖酶并运送编码甘露聚糖酶的多核苷酸。重组宿主细胞也可用于制备具有不同性质的甘露聚糖酶。例如,可以选择这样的宿主细胞,其提供有利于稳定性或活性的翻译后修饰,或其有利于宿主细胞中生成的甘露聚糖酶的后处理和制剂化。
根据第三方面,提供了一种重组多肽,其具有甘露聚糖酶活性,且能够通过使用第二方面所述的宿主细胞获得。
重组多肽可具有将其与具有相同或相似氨基酸序列的天然多肽区分开的结构或功能特性。例如,可以选择这样的宿主细胞,其为所制备的重组多肽提供翻译后修饰、使其缺少翻译后修饰、或定位以促进重组多肽的制备和/或制剂化。
根据第四方面,提供了一种制备甘露聚糖酶的方法,包括:
a、培养第二方面所述的重组宿主细胞,其中
i、所述遗传元件包含至少一种控制序列,该控制序列控制在允许生成所述多肽的条件下在所述重组宿主细胞中生成所述重组多肽;
ii、所述遗传元件选择性地包含至少一个对用于将所述多肽转运到所述宿主细胞外的信号序列进行编码的序列;和
iii、在允许生成所述多肽的条件下进行培养;以及
b、回收所述多肽。
该方法提供了有效的制备甘露聚糖酶的方法。因为甘露聚糖酶是在重组宿主细胞中生成的,所以提供了可以以所需方式进行优化、定制和控制的甘露聚糖酶制备系统。通过该方法制备的甘露聚糖酶可以在结构层面上不同于天然甘露聚糖酶。通过该方法制备的甘露聚糖酶可以,例如,具有糖基化模式或其它翻译后修饰,当与天然甘露聚糖酶(比如具有相似或相同氨基酸序列的甘露聚糖酶)相比或与具有相同氨基酸序列但在另一个宿主细胞中生成的甘露聚糖酶相比时,其导致结构和/或功能的差异。通过该方法制备的甘露聚糖酶可以原样使用或配制成所选定的制剂。
根据另一方面,提供了一种包含重组多肽的酶制剂,该重组多肽具有甘露聚糖酶活性,且能够通过使用第二方面所述的宿主细胞获得。
酶制剂或组合物可进一步包含其它酶和合适的添加剂,所述其它酶选自有或没有介质的蛋白酶、淀粉酶、纤维素酶、脂肪酶、木聚糖酶、甘露聚糖酶、角质酶、酯酶、植酸酶、DNA酶、果胶酶、果胶分解酶、黄原胶酶、木葡聚糖酶、漆酶、过氧化物酶和氧化酶,所述合适的添加剂选自稳定剂、缓冲剂、表面活性剂、漂白剂、介质、抗腐蚀剂、助洗剂、抗再沉积剂、荧光增白剂、染料、颜料、香料、腐蚀剂、研磨剂和防腐剂。
根据第五方面,提供了一种降解或改性含甘露聚糖的材料的方法,包括:用有效量的本发明的酶组合物或重组多肽处理所述含甘露聚糖的材料。
根据第六方面,提供了一种动物饲料,其包含本发明的酶组合物或重组宿主细胞;至少一种源于植物的蛋白质源或含甘露聚糖的制品或副产品;以及a、选择性地,至少一种酶,选自蛋白酶、淀粉酶、植酸酶、木聚糖酶、内切葡聚糖酶、β-葡聚糖酶或其组合;和b、选择性地,至少一种填充剂,选自麦芽糊精、面粉、盐、氯化钠、硫酸盐、硫酸钠或其组合。
根据第七方面,提供了一种饲料添加剂,其包含本发明的酶组合物或能够从宿主细胞获得的酶;以及a、选择性地,至少一种酶,选自蛋白酶、淀粉酶、植酸酶、木聚糖酶、内切葡聚糖酶、β-葡聚糖酶或其组合;和b、选择性地,至少一种填充剂,选自麦芽糊精、面粉、盐、氯化钠、硫酸盐、硫酸钠或其组合。
与不含甘露聚糖酶的饲料相比,该饲料和饲料添加剂改善了饲料的营养价值。本发明的酶组合物降解饲料中存在的甘露聚糖,从而使其更容易被动物消化。特别是对于含有豆粕的饲料,由酶消化生成的甘露寡糖对肠道微生物具有有益作用,因此对动物的行为具有有益作用。通过包含木聚糖酶来消化玉米大豆日粮中存在的阿拉伯木聚糖,可以增强甘露聚糖酶的作用。甘露聚糖酶也可用于改变湿饲料的流变性质。
在一个实施方式中,饲料可以包含动物蛋白,例如肉粉或骨粉。
根据第八方面,提供了第六方面的动物饲料或第七方面的饲料添加剂在以下方面的用途和使用方法:a、饲喂动物,优选为单胃动物或反刍动物;和/或b、促进动物增加体重。
根据第九方面,提供了本发明的酶组合物或能够从宿主细胞中获得的酶在洗涤剂中的用途和使用方法。
在本发明的一个实施方式中,洗涤剂组合物还包含一种或多种附加酶,附加酶选自:蛋白酶、脂肪酶、角质酶、淀粉酶、糖酶、纤维素酶、果胶酶、果胶水解酶、果胶裂解酶、酯酶、甘露聚糖酶、阿拉伯糖酶、半乳糖酶、木聚糖酶、氧化酶、黄原胶酶、木葡聚糖酶、漆酶、DNA酶和/或过氧化物酶,优选地,选自蛋白酶、淀粉酶、纤维素酶和脂肪酶。
在本发明的另一个实施方式中,洗涤剂组合物为以下形式:条(bar)、均质片剂、具有两层或更多层的片剂、具有一个或多个隔室的小袋、常规的或致密的粉末、细粒、糊剂、凝胶、或者常规的、致密的或浓缩的液体。在一个实施方式中,洗涤剂组合物可以是衣物洗涤剂组合物,优选为液体的或固体的衣物洗涤剂组合物。
本发明还涉及本文公开的酶组合物或洗涤剂组合物用于降解甘露聚糖的用途。
在另一个实施方式中,本发明涉及本文公开的酶组合物或洗涤剂组合物在洗衣过程中的用途。
本发明还涉及从表面除去污渍的方法,包括:使表面与本文公开的酶组合物或洗涤剂组合物接触。
本发明还涉及降解甘露聚糖的方法,包括:将本文公开的酶组合物或洗涤剂组合物施加到甘露聚糖,优选地,其中甘露聚糖在纺织品的表面上或至少部分地嵌入纺织品中。
根据第十方面,提供了第一方面的本发明的酶组合物或能够从第三方面的宿主细胞中获得的酶在石油钻探中的用途和使用方法。
本发明的酶组合物有利于改变石油钻井液的流变性质并改善石油的采收。
根据第十一方面,提供了第一方面的本发明酶组合物或能从第三方面的宿主细胞获得的酶在加工咖啡提取物、果汁、菠萝汁或豆浆中的用途和其使用方法。
使用本发明的酶组合物或能够从宿主细胞中获得的酶有利于加工咖啡提取物,因为它降低了咖啡提取物的粘度。
使用本发明的酶组合物或能够从宿主细胞获得的酶有利于加工和制造果汁,因为它降低了粘度,改善了过滤速率、稳定性,并有助于提取水果组分。
使用本发明的酶组合物或能够从宿主细胞中获得的酶有利于加工和制造豆浆,因为它改善了豆浆的产量、颜色、蛋白质含量和味道。
在另一方面,本文公开的序列信息涉及编码本发明的甘露聚糖酶的多核苷酸序列,可用作鉴定其它同源甘露聚糖酶的工具。例如,聚合酶链反应(PCR)可用于扩增对来自多种生物来源的其它同源甘露聚糖酶进行编码的序列。此外,基因组挖掘方法可用于鉴定对来自基因组数据库的其它同源甘露聚糖酶进行编码的序列。
附图说明
图1示出用于在芽孢杆菌中复制的载体pEV1的示意图。
图2示意性地示出用于转化里氏木霉原生质体以过量生成重组甘露聚糖酶蛋白(Man6、Man7和Man14)的表达盒。甘露聚糖酶基因受里氏木霉cel7A/cbh1启动子(pcbh1)控制,并且通过使用里氏木霉cel7A/cbh1终止子序列(tcbh1)确保转录的终止。包含amdS基因作为转化标记。
图3描述了pH值对40mM伯瑞坦-罗宾森(Britton-Robinson)缓冲液(pH4至pH11)中的重组Man6、Man7和Man14(由芽孢杆菌生成的)甘露聚糖酶蛋白活性的影响。反应温度为50℃,反应时间为10分钟。使用天青蛋白交联的角豆半乳甘露聚糖(azurine-crosslinkedcarob galactomannan)作为底物。所有测量至少重复一次。数据点是各单独测量的平均值。
图4示出使用10分钟反应时间在40mM伯瑞坦-罗宾森缓冲液(pH7)中测定的重组Man6、Man7和Man14(由芽孢杆菌生成的)甘露聚糖酶的温度曲线,使用天青蛋白交联的角豆半乳甘露聚糖作为底物。所有测量至少重复一次。数据点是各单独测量的平均值。
图5示出细菌甘露聚糖酶的SDS PAGE(十二烷基硫酸钠-聚丙烯酰胺凝胶电泳)分析。
图6描述了在存在4.4g/l市售重垢液体洗涤剂A的情况下,在40℃、16°dH、60分钟、pH值约8.3和酶作为活性单位添加时,(在芽孢杆菌和木霉属中生成的)Man6和Man7的去污性能,去污性能即亮度的增加(4种污渍的ΔL*的总和)。市售制剂4.0L用于对比。
图7描述了在存在4.4g/l市售重垢液体洗涤剂A的情况下,在40℃、16°dH、60分钟、pH值约8.3和酶作为活性酶蛋白(AEP)添加时,(在芽孢杆菌中生成的)Man6和Man7的去污性能,去污性能即亮度的增加(4种污渍的ΔL*的总和)。市售制剂4.0L用于对比。
图8描述了在存在3.8g/l市售彩色洗涤剂粉末的情况下,在40℃、16°dH、60分钟、pH值约10和酶作为活性单位添加时,(在芽孢杆菌中生成的)Man6和Man7的去污性能,去污性能即亮度的增加(4种污渍的ΔL*的总和)。市售制剂4.0L用于比较。
图9描述了在存在3.8g/l市售彩色洗涤剂粉末的情况下,在40℃、16°dH、60分钟、pH值约10和酶作为活性酶蛋白添加时,(在芽孢杆菌中生成的)Man6和Man7的去污性能,去污性能即亮度的增加(4种污渍的ΔL*的总和)。市售制剂4.0L用于比较。
图10描述了在存在4.2g/l市售漂白洗涤剂粉末的情况下,在40℃、16°dH、60分钟、pH值约9.5和酶作为活性酶蛋白添加时,(在芽孢杆菌中生成的)Man6和Man7的去污性能,去污性能即亮度的增加(3种污渍的ΔL*的总和)。市售制剂4.0L用于比较。
图11描述了在存在5g/l市售重垢液体洗涤剂B的情况下,在40℃、16°dH、60分钟、pH值约8.3和酶作为活性单元添加时,(在芽孢杆菌中生成的)Man14的去污性能,去污性能即亮度的增加(两种污渍的ΔL*的总和)。市售制剂4.0L用于比较。
图12描述了在存在5g/l市售重垢液体洗涤剂B的情况下,在40℃、16°dH、60分钟、pH值约8.3和酶作为活性酶蛋白添加时,(在芽孢杆菌中生成的)Man14的去污性能,去污性能即亮度的增加(两种污渍的ΔL*的总和)。市售制剂4.0L用于比较。
图13描述了在37℃下(在芽孢杆菌中生成的)Man6和Man7在液体洗涤剂(OMOColor)中的稳定性。市售制剂4.0L用于比较。
图14描述了市售重垢液体洗涤剂A中(在芽孢杆菌和木霉属中生成的)Man7和(在芽孢杆菌中生成的)Man6的稳定性。市售制剂4.0L用于比较。
图15示出与使用本发明的甘露聚糖酶有关的速溶咖啡生产的流程图。
序列表
SEQ ID NO:1寡核苷酸引物Man6_1的序列
SEQ ID NO:2寡核苷酸引物Man6_2的序列
SEQ ID NO:3寡核苷酸引物Man7_1的序列
SEQ ID NO:4寡核苷酸引物Man7_2的序列
SEQ ID NO:5寡核苷酸引物Man14_1的序列
SEQ ID NO:6寡核苷酸引物Man14_2的序列
SEQ ID NO:7寡核苷酸引物Vec_1的序列
SEQ ID NO:8寡核苷酸引物Vec_2的序列
SEQ ID NO:9克劳氏芽孢杆菌的核苷酸序列man6
SEQ ID NO:10不含信号肽编码序列且按里氏木霉密码子优化的克劳氏芽孢杆菌的核苷酸序列man6
SEQ ID NO:11克劳氏芽孢杆菌的推导的氨基酸序列Man6
SEQ ID NO:12不含信号肽的克劳氏芽孢杆菌的推导的氨基酸序列Man6
SEQ ID NO:13解半纤维素芽孢杆菌(Bacillus hemicellulosilyticus)的核苷酸序列man7
SEQ ID NO:14不含信号肽编码序列且按里氏木霉密码子优化的解半纤维素芽孢杆菌的核苷酸序列man7
SEQ ID NO:15解半纤维素芽孢杆菌的推导的氨基酸序列Man7
SEQ ID NO:16不含信号肽的解半纤维素芽孢杆菌的推导的氨基酸序列Man7
SEQ ID NO:17土壤枝芽孢杆菌(Virgibacillus soli)的核苷酸序列man14
SEQ ID NO:18不含信号肽编码序列且按里氏木霉密码子优化的土壤枝芽孢杆菌的核苷酸序列man14
SEQ ID NO:19土壤枝芽孢杆菌的推导的氨基酸序列Man14
SEQ ID NO:20不含信号肽的土壤枝芽孢杆菌的推导的氨基酸序列Man14
SEQ ID NO:21寡核苷酸引物BMAN1的序列
SEQ ID NO:22寡核苷酸引物BMAN2的序列
SEQ ID NO:23寡核苷酸引物BMAN3的序列
SEQ ID NO:24寡核苷酸引物BMAN4的序列
SEQ ID NO:25短小芽孢杆菌的核苷酸序列man31
SEQ ID NO:26短小芽孢杆菌的推导的氨基酸序列Man31
SEQ ID NO:27解淀粉芽孢杆菌的核苷酸序列man32
SEQ ID NO:28解淀粉芽孢杆菌的推导的氨基酸序列Man32
SEQ ID NO:29木聚糖兼性芽孢杆菌(Amphibacillus xylanus)的核苷酸序列man33
SEQ ID NO:30木聚糖兼性芽孢杆菌(Amphibacillus xylanus)的推导的氨基酸序列Man33
SEQ ID NO:31多粘类芽孢杆菌(Paenibacillus polymyxa)的核苷酸序列man34
SEQ ID NO:32多粘类芽孢杆菌的推导的氨基酸序列Man34
SEQ ID NO:33解半纤维素酶芽孢杆菌的核苷酸序列man35
SEQ ID NO:34解半纤维素酶芽孢杆菌的推导的氨基酸序列Man35
SEQ ID NO:35嗜碱芽孢杆菌(Bacillus alcalophilus)的核苷酸序列man36
SEQ ID NO:36嗜碱芽孢杆菌的推导的氨基酸序列Man36
SEQ ID NO:37芽孢杆菌属菌种(Bacillus sp.)的核苷酸序列man37
SEQ ID NO:38芽孢杆菌属菌种的推导的氨基酸序列Man37
SEQ ID NO:39环状芽孢杆菌(Bacillus circulans)的核苷酸序列man38
SEQ ID NO:40环状芽孢杆菌的推导的氨基酸序列Man38
SEQ ID NO:41类芽孢杆菌属菌种(Paenibacillus sp.)的核苷酸序列man39
SEQ ID NO:42类芽孢杆菌属菌种的推导的氨基酸序列Man39
SEQ ID NO:43环状芽孢杆菌的核苷酸序列man40
SEQ ID NO:44环状芽孢杆菌的推导的氨基酸序列Man40
SEQ ID NO:45尼氏芽孢杆菌(Bacillus nealsonii)的核苷酸序列man41
SEQ ID NO:46尼氏芽孢杆菌Man41的推导的氨基酸序列Man41
SEQ ID NO:47环状芽孢杆菌的核苷酸序列man42
SEQ ID NO:48环状芽孢杆菌的核苷酸序列Man42
具体实施方式
甘露聚糖是指由通过β-1,4键连接在一起的甘露糖主链构成的多糖,其中半乳糖的侧链通过α-1,6键连接到主链上。甘露聚糖包含植物性材料如瓜尔胶和刺槐豆胶。葡甘露聚糖是这样的多糖:其具有或多或少规则交替的β-1,4连接的甘露糖和葡萄糖的主链。半乳甘露聚糖和半乳葡甘露聚糖是具有α-1,6连接的半乳糖侧链的甘露聚糖和葡甘露聚糖。
如本文所用,术语“甘露聚糖酶”或“半乳甘露聚糖酶”是指根据本领域已知的甘露聚糖内切-1,4-β-甘露糖苷酶定义的甘露聚糖酶,具有别名β-甘露聚糖酶和内切-1,4-甘露聚糖酶,且促进甘露聚糖、半乳甘露聚糖、葡甘露聚糖和半乳葡甘露聚糖中的1,4-β-D-甘露糖苷键的水解。根据酶命名法甘露聚糖酶被分类为EC 3.2.1.78。
如本文所用,“分离的”是指在具有自然界中不存在的形式或自然界中不存在的环境中的物质。分离的物质的非限制性例子包括:(1)任何非天然存在的物质,(2)从一个或多个或所有与自然有关的天然存在的成分至少部分地除去的任何物质,包括任何酶、变体、核酸,蛋白质、肽或辅因子;(3)相对于在自然界中发现的物质,任何经人的手改变的物质;或者(4)任何通过相对于与其天然相关的其它成分增加或减少该物质的量而被改变的物质,例如,宿主细胞中的重组生成;编码该物质的基因的一个或多个拷贝;以及对与编码该物质的基因天然相关的启动子使用替代性启动子。在一个实施方式中,本发明的多肽、酶、多核苷酸、宿主细胞或组合物是分离的。
如本文所用,术语“包括”既包括广义的“包括”、“包含”和“含有”,也包括狭义的表达“由...组成”和“仅由......组成”。
如本文所用,“片段”指缺失一个或多个氨基酸或核苷酸的蛋白质或多核苷酸。在DNA的背景下,片段包括任何长度的单链DNA和双链DNA。片段可以是活性片段,其具有蛋白质或多核苷酸的生物学功能,如酶活性或调节活性。片段也可以是无活性片段,即它不具有天然蛋白质或多核苷酸的一种或多种生物学效应。
如本文所用,“肽”和“多肽”是包括多个连续的聚合氨基酸残基的氨基酸序列。为了本发明的目的,肽是包含不多于20个氨基酸残基的分子,多肽则包含超过20个氨基酸残基。肽或多肽可以包括修饰了的氨基酸残基、未由密码子编码的天然存在的氨基酸残基、和非天然存在的氨基酸残基。如本文所用,“蛋白质”可以指任何大小的肽或多肽。蛋白质可以是酶、蛋白、抗体、膜蛋白、肽激素、调节剂或任何其它蛋白。
术语“多核苷酸”是指从5’至3’端读码的脱氧核糖核苷酸或核糖核苷酸碱基的单链或双链聚合物。多核苷酸包括RNA和DNA,且可以从天然来源分离、在体外合成、或者由天然和合成分子的组合来制备。
如本文所用,多核苷酸背景下的“修饰”、“修饰的”和类似术语是指多核苷酸的编码或非编码区(如调节序列、5’非翻译区、3’非翻译区、上调遗传元件、下调遗传元件、增强子、抑制子、启动子、外显子或内含子区域)中的修饰。在一些实施方式中,修饰可以仅是结构性的,对多核苷酸的生物效应、作用或功能没有影响。在其它实施方式中,修饰是提供多核苷酸的生物效应、作用或功能变化的结构修饰。这种修饰可以增强、抑制或改变多核苷酸的生物学功能。
如本文所用,“同一性”是指两个比对序列之间的氨基酸残基的精确匹配数除以存在于两个序列的残基所处位置的总数所得的百分比。当一个序列具有的残基在另一个序列中没有相应残基时,比对程序允许比对中有间隙,且该位置不计入计算同一性的分母中。同一性是在EMBL-EBI网站上用成对序列比对工具EMBOSS Needle确定的值(www.ebi.ac.uk/Tools/psa/emboss_needle/)。
如本文所用,“宿主细胞”是指对核酸构建体或包含多核苷酸的表达载体易于转化、转染、转导、交配、杂交等的任何细胞类型。术语“宿主细胞”包括由于复制过程中发生的突变而不相同的任何后代。宿主细胞的非限制性例子有:真菌细胞,选自子囊菌门、盘菌亚门的细丝真菌细胞,优选地选自粪壳菌纲、肉座菌亚纲、肉座菌目、小囊菌目的成员、以及曲霉、金孢霉、毁丝霉和腐质霉;更优选地选自:肉座菌科、丛赤壳科、麦角菌科、小囊菌科、木霉属(肉座菌属的无性型)、镰刀菌属、赤霉属、丛赤壳属、穗霉属、麦角菌属、绿僵菌属、稻曲菌(Villosiclava)属、蛇形虫草属、头孢菌属和丝孢菌属;更优选地选自:里氏木霉(红褐肉座菌)、桔绿木霉、长枝木霉、绿木霉、哈茨木霉、棘孢木霉、深绿木霉、拟里氏木霉、尖孢镰刀菌、禾谷镰刀菌、小麦冠腐病菌、镰孢霉、藤仓赤霉、串珠状赤霉、玉蜀黍赤霉、红球丛赤壳菌(血赤壳菌)、黑葡萄穗霉、穗霉(Stachybotrys chlorohalonata)、紫色麦角菌、蝗绿僵菌、金龟子绿僵菌、稻曲病菌、冬虫夏草菌、顶头孢霉(产黄头孢霉)、尖端赛多孢子菌、黑曲霉、泡盛曲霉、米曲霉、金孢子菌(Chrysosporium lucknowense)、嗜热毁丝霉、腐质霉和灰腐质霉;最优选为里氏木霉。宿主细胞的非限制性例子有:细菌细胞,优选为革兰氏阳性杆菌(例如枯草芽孢杆菌、地衣芽孢杆菌、巨大芽孢杆菌、解淀粉芽孢杆菌、短小芽孢杆菌)、革兰氏阴性细菌(例如大肠杆菌)、放线菌(例如链霉菌),以及酵母(例如酿酒酵母、毕赤酵母、解脂耶罗维亚酵母)。
在一个实施方式中,宿主细胞是真菌细胞,优选为丝状真菌细胞,如木霉属或里氏木霉。在一个实施方式中,宿主细胞是细菌细胞,优选为革兰氏阳性芽孢杆菌细胞,如枯草芽孢杆菌、地衣芽孢杆菌、巨大芽孢杆菌、解淀粉芽孢杆菌、短小芽孢杆菌。
“重组细胞”或“重组宿主细胞”是指这样的细胞或宿主细胞:其已被遗传修饰或改变以包含不是所述细胞或宿主细胞天然具有的核酸序列。在一个实施方式中,遗传修饰包括将多核苷酸整合到宿主细胞的基因组中。在另一个实施方式中,多核苷酸在宿主细胞中是外源的。
如本文所用,“表达”包括在宿主细胞中生成多肽所涉及的任何步骤,包括但不限于转录、翻译、翻译后修饰和分泌。表达之后可以收集,即回收宿主细胞或被表达的产物。
术语“表达载体”是指包含编码目的多肽的片段的线性或环状DNA分子,该编码目的多肽的片段与为其转录提供的其它片段可操作地连接。这些附加片段可包括启动子序列和终止子序列,并且可以选择性地包括一个或多个复制起点、一个或多个选择标记、增强子、多腺苷酸化信号、载体等。表达载体通常衍生自质粒或病毒DNA,或可以含有两者的元件。表达载体可以是任何方便地进行重组DNA操作的表达载体,载体的选择通常取决于载体将被导入的宿主细胞。因此,载体可以是自主复制载体,即,作为染色体外实体存在的载体,其复制独立于染色体复制,例如质粒。或者,载体可以是这样的载体:当其被导入宿主细胞时,其被整合到宿主细胞基因组中并和与其整合的染色体一起被复制。
本文所用的与多肽或蛋白质的生成有关的术语“重组生成的”根据本领域的标准定义来定义。
本文所用的与特定微生物来源有关的术语“从......获得的”和“能够获得的”是指多核苷酸由特定来源进行表达(同源表达),或由其中插入了来自来源的基因的细胞进行表达(异源表达)。
术语“酶组合物”是指来自单一种类的微生物的常规酶发酵产物,可能是分离和纯化的,这种制剂通常包含许多不同的酶活性;或者是单组分酶的混合物,优选为通过使用常规重组技术从细菌或真菌物种衍生的酶,所述酶已经发酵并且可能已经分离和分别纯化,而且可以源自不同物种,优选为真菌或细菌物种,或者微生物的发酵产物,该微生物用作生成重组甘露聚糖酶的宿主细胞,但该微生物同时生成其它酶。
当提及DNA片段时,术语“可操作地连接”是指片段被排列成,为了它们的预期目的它们一致地起作用,例如,转录在启动子中开始并通过编码片段进入终止子。
术语“启动子”是指含有为RNA聚合酶结合和转录起始提供的DNA序列的基因的一部分。启动子序列通常(但不总是)存在于基因的5’非编码区中。
术语“分泌信号序列”是指编码多肽(“分泌肽”)的DNA序列,该多肽作为较大多肽的组分,指导较大的多肽通过生成它的宿主细胞的分泌途径。分泌信号序列可以是天然的,或者也可以用来自另一来源的分泌信号序列或载体序列替换。取决于宿主细胞,较大的肽可以在运送过程中通过分泌途径被切割以除去分泌肽。
术语“核心区”是指酶的结构域,其可以经过或者不经过修饰或改变,但保留了其原始活性的至少一部分;催化结构域在本领域中公知保持了功能性。根据本发明的甘露聚糖酶的核心区对应于以以下氨基酸序列排列的氨基酸:Man7(SEQ ID NO:16)的氨基酸27-331,Man6(SEQ ID NO:12)的氨基酸35-324,或者Man14(SEQ ID NO:20)的氨基酸17-314。
术语“接头”或“间隔基”是指包含至少两个氨基酸的多肽,其可存在于多结构域蛋白质(例如,包含酶核心和结构域比如碳水化合物结合模块(CBM)的酶或任何其它酶杂合体)的结构域之间,或者存在于作为融合多肽(例如包含两种核心酶的融合蛋白)生成的两种蛋白或多肽之间。例如,通过将编码酶核心的DNA序列,编码接头的DNA序列和编码CBM的DNA序列依次连接到一个开放读码框架中并表达该构建体来提供酶核心与CBM的融合蛋白。
有效量是指足以使所选应用中的甘露糖被降解的量。
除非另有说明,术语“洗涤剂组合物”和“洗涤剂”包括:固体、颗粒或粉末形式的全效或重垢洗涤剂,尤其是清洁洗涤剂;液体、凝胶或糊剂形式的全效洗涤剂,尤其是所谓的重垢液体(HDL)类型;精细织物液体洗涤剂;手洗餐具或轻型餐具洗涤剂,特别是高发泡型的;机器洗碗剂,包括家用和机构用的各种片剂、颗粒剂、液体剂和漂洗助剂;液体清洁和消毒剂,汽车或地毯香波,浴室清洁剂;金属清洁剂;以及清洁辅助剂,如漂白添加剂和“去污渍棒(stain-stick)”或预处理类型。术语“洗涤剂”、“洗涤剂组合物”和“洗涤剂制剂”用于指这样的混合物,其旨在用于洗涤介质中以清洁被污染物体。在一些实施方式中,该术语用于指洗涤织物和/或衣服(例如“衣物洗涤剂”)。在替代实施方式中,该术语指其它洗涤剂,例如用于清洁器皿、餐具等的洗涤剂(例如“餐具洗涤剂”)。并不试图将本发明限于任何特定的洗涤剂制剂或组合物。除了根据本发明的甘露聚糖酶之外,该术语涵盖的洗涤剂还可含有:例如表面活性剂、助洗剂、螯合剂、漂白剂系统或漂白剂组分、聚合物、织物整理剂、泡沫促进剂、抑泡剂、染料、香料、色暗抑制剂、荧光增白剂、杀细菌剂、杀真菌剂、污物悬浮剂、抗腐蚀剂、助水溶剂、织物调色剂、分散剂、染料转移抑制剂、荧光增白剂、去污聚合物、抗再沉积剂、抗收缩剂、抗皱剂、杀细菌剂、粘合剂、载体、染料、酶稳定剂、织物柔软剂、填料、泡沫调节剂、香料、颜料、草渍抑制剂、溶剂以及液体洗涤剂结构剂、结构弹性剂、酶抑制剂或稳定剂、酶活化剂、转移酶、水解酶、氧化还原酶、上蓝剂和荧光染料、抗氧化剂和增溶剂。
术语“纺织品”是指任何纺织材料,包括纱线、纱线中间体、纤维、无纺材料、天然材料、合成材料和任何其它纺织材料、由这些材料制成的织物和由织物制成的产品(例如服装、亚麻织品和其它物品)。所述纺织品或织物可以采取编织物、机织物、牛仔布、无纺织物、毡、纱线和毛巾布的形式。所述纺织品可以是基于纤维素的例如天然纤维素,包括棉、亚麻/亚麻布、黄麻、苎麻、剑麻或椰壳纤维,或人造纤维素(例如源自于木浆),包括粘胶纤维/人造丝、苎麻、醋酸纤维素纤维(tricell)、莱赛尔纤维或其混合物。纺织品或织物也可以是非纤维素基的,例如天然聚酰胺包括羊毛、驼毛、羊绒、马海毛、兔毛和蚕丝,或者合成聚合物如尼龙、芳族聚酰胺、聚酯、丙烯酸、聚丙烯和氨纶/弹性纤维,或它们的混合物,以及纤维素基纤维和非纤维素基纤维的混合物。混合物的例子有棉和/或人造丝/粘胶与一种或多种伴纺材料的混合物,伴纺材料例如羊毛、合成纤维(例如聚酰胺纤维、丙烯酸纤维、聚酯纤维、聚乙烯醇纤维、聚氯乙烯纤维、聚氨酯纤维、聚脲纤维、芳族聚酰胺纤维)和含纤维素的纤维(例如人造丝/粘胶纤维、苎麻、亚麻/亚麻布、黄麻、醋酸纤维素纤维、莱赛尔纤维)。织物可以是常规的可洗衣物,例如染色的家用衣物。当使用术语织物或服装时,它旨在也包括更广义的术语纺织品。
术语“稳定性”包括储存稳定性和使用期间(例如在洗涤过程中)的稳定性(洗涤中稳定性),反映出根据本发明的甘露聚糖酶的稳定性随时间的变化,例如,在将甘露聚糖酶置于溶液中(尤其洗涤剂溶液中)时保留了多少活性。影响稳定性的因素很多,例如pH值、温度、洗涤剂组合物,例如蛋白酶、稳定剂、助洗剂、表面活性剂等。可以使用在实施例中描述的“活性测定”来测量甘露聚糖酶稳定性。
如本文所用的“甘露聚糖酶活性”是指多肽的甘露聚糖降解活性。如本文所用的降解或修饰是指甘露糖单元被甘露聚糖酶从甘露聚糖水解。可以根据本领域已知的标准测试方法测试根据本发明的多肽的甘露聚糖降解活性。实施例7提供了用于确定甘露聚糖酶活性的标准方法的例子。
在本发明的另一个实施方式中,至少一种酶具有甘露聚糖酶活性。本发明的酶组合物中包含的甘露聚糖酶适合用于在各种化学环境中(优选地,在洗涤剂组合物中)降解和改性含甘露聚糖的材料。
在本发明的一个实施方式中,酶组合物还包含一种或多种附加酶,附加酶选自:蛋白酶、脂肪酶、角质酶、淀粉酶、糖酶、纤维素酶、果胶酶、果胶水解酶、果胶裂解酶、酯酶、植酸酶、甘露聚糖酶、阿拉伯糖酶、半乳糖酶、木聚糖酶、氧化酶、黄原胶酶、木葡聚糖酶、DNA酶、漆酶和/或过氧化物酶,优选地,选自蛋白酶、淀粉酶、纤维素酶和脂肪酶。
包含甘露聚糖酶和附加酶的本发明的酶组合物有利于提供协同效应。当本发明的包含甘露聚糖酶的酶组合物用于洗涤剂时,例如洗涤污渍时,需要这些附加酶。与甘露聚糖酶一起使用的特别有利的协同酶是淀粉酶、蛋白酶和纤维素酶,或它们的组合,如包含甘露聚糖酶、淀粉酶和蛋白酶的组合物。
通常,所选择的酶的性质应与所选择的洗涤剂相容(即,最佳pH值、与其它酶和非酶成分的相容性等),而且应当有有效量的该酶。
例如,用于固体衣物洗涤剂的组合物可以包含,按组合物的重量计,0.000001%-5%,如0.000005-2%,如0.00001%-1%,如0.00001%-0.1%的酶蛋白。
例如,用于洗衣液的组合物可以包含,按组合物的重量计,0.000001%-3%,如0.000005%-1%,如0.00001%-0.1%的酶蛋白。
例如,用于自动餐具清洁的组合物可以包含,按组合物的重量计,0.000001%-5%,如0.000005%-2%,如0.00001%-1%,如0.00001%-0.1%的酶蛋白。
在本发明的另一个实施方式中,洗涤剂组合物为以下形式:条、均质片剂、具有两层或更多层的片剂、具有一个或多个隔室的小袋、常规的或致密的粉末、细粒、糊剂、凝胶、或者常规的、致密的或浓缩的液体。在一个实施方式中,洗涤剂组合物可以是衣物洗涤剂组合物,优选为液体的或固体的衣物洗涤剂组合物。洗涤剂制剂的形式有很多种,例如层(相同的相或不同的相)、小袋、以及用于机器加料单元的形式。
在一个实施方式中,本发明的酶组合物还包含:
a、至少一种防腐剂,选自苯甲酸、苯甲酸钠、羟基苯甲酸酯、柠檬酸、抗坏血酸或其组合;
b、选择性地,至少一种多元醇,选自丙二醇、甘油、糖、糖醇、乳酸、硼酸、硼酸衍生物、芳香硼酸酯、苯基硼酸衍生物、肽或其组合;
c、选择性地,至少一种酶,选自有或没有介质的蛋白酶、淀粉酶、纤维素酶、脂肪酶、木聚糖酶、甘露聚糖酶、角质酶、酯酶、植酸酶、DNA酶、果胶酶、果胶水解酶、果胶裂解酶、糖苷酶、阿拉伯糖酶、半乳糖酶、黄原胶酶、木葡聚糖酶、漆酶、过氧化物酶和氧化酶或其组合;以及
d、选择性地,至少一种填充剂,选自麦芽糊精、面粉、氯化钠、硫酸盐、硫酸钠或其组合。
附加组分a-d为本发明的酶组合物提供了改进的性质。酶组合物与附加组分相容并改善酶组合物在各种用途中的适用性。
盐,比如氯化钠和硫酸钠,起到干燥助剂的作用。
在第一方面的一个实施方式中,本发明的酶组合物为液体组合物或固体组合物的形式,如溶液、分散剂、糊剂、粉末、细粒、颗粒、包衣颗粒、片剂、糕剂、晶体、晶体浆液、凝胶或丸粒。
本发明还涉及本文公开的酶组合物的不同用途,例如用于降解甘露聚糖和用于洗衣过程。
酶组合物也可用于清洁剂或增效剂中,所述清洁剂或增效剂在洗涤期间或之前添加到洗涤剂之上,并且是以例如液体、凝胶、粉末、颗粒或片剂的形式。酶组合物和洗涤剂组分也可以浸泡在诸如纺织品的载体中。
在一个实施方式中,甘露聚糖酶在5.5至8.5的pH范围内具有至少50%的相对活性。相对活性可以通过实施例7中描述的方法确定。
在本发明的一个实施方式中,甘露聚糖酶在45℃-65℃的温度范围内具有至少30%的相对活性。
提供在高于环境温度的温度下依然保持活性的甘露聚糖酶对于需要在这种条件下降解甘露聚糖的应用是有利的。此外,根据本发明的甘露聚糖酶在碱性条件下可具有良好的稳定性和活性,这在洗涤剂用途和生物质加工中是有利的。
在一个实施方式中,甘露聚糖酶具有的氨基酸序列与SEQ ID NO:12具有至少或大约93%、94%、95%、96%、97%、98%、99%或100%的序列同一性。
在一个实施方式中,甘露聚糖酶具有的氨基酸序列与SEQ ID NO:16具有至少或大约70%、71%、72%、73%、74%、75%、76%、77%、78%、79%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%的序列同一性。
在一个实施方式中,甘露聚糖酶具有的氨基酸序列与SEQ ID NO:20具有至少或大约79%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%的序列同一性。
在一个实施方式中,甘露聚糖酶具有与SEQ ID NO:12[Man6]、SEQ ID NO:16[Man7]或SEQ ID NO:20[Man14]不是100%相同的氨基酸序列。
在一个实施方式中,本发明的酶组合物包含第二方面的重组宿主细胞。
在第二方面的一个实施方式中,重组多肽是融合蛋白,其除了包含具有甘露聚糖酶活性的氨基酸序列外,还包含下列中的至少一种:
提供分泌信号序列的氨基酸序列,如解淀粉芽孢杆菌木聚糖酶信号肽;
促进纯化的氨基酸序列,如亲和标签、组氨酸标签;
促进制备的氨基酸序列,如作为载体的氨基酸序列,比如CBM;
具有酶活性的氨基酸序列;以及
为具有结合亲和力的融合蛋白提供的氨基酸序列,如碳水化合物结合部分。
CBM,碳水化合物结合部分,作为载体例如在木霉制备中是有利的。
在一个实施方式中,宿主细胞是非致病性的。这对于在饲料中使用宿主细胞以及在家用洗衣洗涤剂等洗涤剂应用中使用宿主细胞是特别有利的。
在第五方面的一个实施方式中,含甘露聚糖的材料选自植物性材料、纺织品、废水、污水、油或其其组合。
在另一个实施方式中,含甘露聚糖的材料是回收的废纸;机械浆、化学浆、半化学浆、牛皮纸浆或其它造纸浆;经过浸沤加工的纤维;或者,含瓜尔胶或刺槐豆胶的材料。
在另一个实施方式中,降解或修饰在水性环境中进行,甘露聚糖酶在该水性环境中显示出活性。
在一个优选的实施方式中,在该方法中被降解或改性的含甘露聚糖的材料在纺织品或织物上,选择性地,该纺织品或织物具有甘露聚糖污渍。通过降解附着在织物或织物上的甘露聚糖,与甘露聚糖结合的污物或污垢被释放,而且不能再结合到甘露聚糖或甘露聚糖污渍上。纺织品或织物可以是任何材料,例如棉、亚麻/亚麻布、黄麻、苎麻、剑麻或椰壳纤维,或者人造纤维素(例如源自于木浆),包括粘胶纤维/人造丝、苎麻、醋酸纤维素纤维(tricell)、莱赛尔纤维、铜氨纤维或其混合物。
在第六方面的一个实施方式中,动物是单胃动物或反刍动物。在另一个实施方式中,动物是肉鸡、蛋鸡、猪、火鸡或水产养殖生物比如鱼。在另一个实施方式中,动物是反刍动物。
在一个实施方式中,饲料包含玉米和豆粕,或者由玉米和豆粕组成。
在一个实施方式中,植物来源的蛋白质源包含大豆,谷类如大麦、小麦、黑麦、燕麦或玉米,或者由它们组成。
在一个实施方式中,含甘露聚糖的制品或副产品包含棕榈仁、瓜尔豆粉或椰子粉,或者由它们组成。
在第六方面或第七方面的一个实施方式中,动物饲料或饲料添加剂被制成湿组合物或干组合物的形式。
在第九方面的一个实施方式中,洗涤剂是液体洗涤剂或固体洗涤剂,优选为粉末、条、片剂、小袋、糊剂、凝胶、液体、细粒或颗粒的形式。
在一个实施方式中,包含至少一种甘露聚糖酶的组合物用于纸浆和造纸工业、生物漂白、纤维改性、排水改进,以及用于石油工业,即,用于石油钻探或石油维修工业中用于水力压裂或控制钻井液的粘度。
在一个实施方式中,包含至少一种甘露聚糖酶的组合物用于纺织品和洗涤剂工业、生物质加工和生物质水解,优选地,用于生物燃料、淀粉、纸浆和纸、食品、烘焙、饲料或饮料工业。
在一个实施方式中,甘露聚糖酶随机水解内切-β-1,4-甘露糖苷键。
在一个实施方式中,甘露聚糖酶是可从细菌来源获得或衍生的。
在一个实施方式中,甘露聚糖酶可以与至少一种其它多肽融合,从而形成融合多肽。除了对甘露聚糖酶的催化或结合活性之外,所述融合多肽或其它多肽可以具有其它的催化或结合活性。在一个实施方式中,所述其它多肽包含碳水化合物结合模块或由碳水化合物结合模块组成,其选择性地是衍生自与甘露聚糖酶相同或不同的有机物的另一种蛋白或酶的片段。
在一个实施方式中,甘露聚糖酶通过接头与所述其它多肽连接。
在一个实施方式中,提供了一种织物的机器处理方法,该方法包括:在机器洗涤过程的洗涤循环期间,采用含有第一方面的酶组合物、可从第二方面的重组宿主细胞获得的酶或第三方面的重组多肽的洗涤溶液处理织物。
在一个实施方式中,提供了第一方面的酶组合物、可从第二方面的重组宿主细胞获得的酶、或第三方面的多肽与选自以下的酶一起在用于织物清洗和/或织物去污的清洁组合物中的用途:有或没有介质的蛋白酶、淀粉酶、纤维素酶、脂肪酶、木聚糖酶、甘露聚糖酶、角质酶、酯酶、植酸酶、DNA酶、果胶酶、果胶水解酶、果胶裂解酶、糖苷酶、阿拉伯糖酶、半乳糖酶、黄原胶酶、木葡聚糖酶、漆酶、过氧化物酶和氧化酶。
在一个实施方式中,提供了第一方面的酶组合物、可从第二方面的重组宿主细胞获得的酶、或第三方面的多肽与选自以下的酶一起在用于清洁硬表面如地板、墙壁、浴室瓷砖等的清洁组合物中的用途:有或没有介质的蛋白酶、淀粉酶、纤维素酶、脂肪酶、木聚糖酶、甘露聚糖酶、角质酶、酯酶、植酸酶、DNA酶、果胶酶、果胶水解酶、果胶裂解酶、糖苷酶、阿拉伯糖酶、半乳糖酶、黄原胶酶、木葡聚糖酶、漆酶、过氧化物酶和氧化酶。
在一个实施方式中,提供了第一方面的酶组合物、可从第二方面的重组宿主细胞获得的酶、或第三方面的多肽与选自以下的酶一起在用于手洗和机洗餐具的的清洁组合物中的用途:有或没有介质的蛋白酶、淀粉酶、纤维素酶、脂肪酶、木聚糖酶、甘露聚糖酶、角质酶、酯酶、植酸酶、DNA酶、果胶酶、果胶水解酶、果胶裂解酶、糖苷酶、阿拉伯糖酶、半乳糖酶、黄原胶酶、木葡聚糖酶、漆酶、过氧化物酶和氧化酶。
实施例
提供以下实施例以说明本发明的各个方面。它们并非用来限制本发明,本发明由所附权利要求限定。
实施例1:筛选
为了鉴定新的β-1,4-甘露聚糖酶,筛选公共数据库(NCBI,EBI)和选定的专有和公共基因组。表1列出了在这项工作中使用的所有专有和公共基因组。将所有中选的基因组分组,最后根据相互之间的群落谱系距离(phylogenetic distance)选择15个细菌来源基因,用于在芽孢杆菌中进行克隆(表2)。
表1:用于筛选β-1,4-甘露聚糖酶的专有和公共基因组的列表
菌种 | 菌株 | 来源 |
短小芽胞杆菌 | MS8 | ABE |
木聚糖兼性芽孢杆菌 | NBRC 15112 | NCBI |
解半纤维素芽孢杆菌 | JCM 9152 | NCBI |
克劳氏芽孢杆菌 | KSM-K16 | NCBI |
解淀粉芽孢杆菌 | RH1330 | ABE |
土壤枝芽孢杆菌 | PL205 | NCBI |
表2:为了在芽孢杆菌中克隆而选择的基因列表。示出预测的PFAM结构域和蛋白质的氨基酸长度
实施例2:芽孢杆菌中的细菌甘露聚糖酶的克隆
除非另有说明,包括DNA操作和转化的分子生物学方法如Sambrook和Russell(2001)以及Harwood和Cutting(1990)中所述的进行。使用Pfx Accu Prime聚合酶(Invitrogen公司)通过PCR扩增基因man6、man7和man14。按照制造商的说明书书进行PCR。以下PCR条件用于构建表达质粒:在94℃下初始变性120秒,然后在94℃下进行35个15秒循环,在以下50/55℃之一退火30秒:,在68℃下延伸110/290秒,最后在68℃下延伸10分钟。为了扩增man7,使用半纤维素芽孢杆菌JCM9152的基因组DNA。订购man6和man14,作为未进行密码子优化的合成基因(Eurofins MWG公司,德国)。用于克隆的引物的序列在表3中表示。对用于杂交的突出部分加下划线。
表3:用于扩增man6、man7和man14的引物列表
通过使用高保真DNA组装预混液(Hifi DNA AssemblyMaster Mix,NEB公司,法兰克福),将基因克隆到标准载体pEV1pEV1(图1)中,标准载体pEV1是包括来自地衣芽孢杆菌的启动子PaprE和来自解淀粉芽孢杆菌的木聚糖酶信号肽的pUB110衍生物。克隆时使用的载体与插入片段的比率为1:3。片段的总量为0.2pmol,总体积为20μl。将样品在50℃下培养40分钟。为了构建的目的,如Zhang和Zhang 2011中所述,通过枯草芽孢杆菌SCK6中的诱导能力来转化表达质粒。将转化的细胞接种到添加了10mg/l卡那霉素的LB(Luria-Bertani)培养板上。将培养板在37℃下培养20小时。挑取出现的菌落,用QiaPrep MiniPrep试剂盒(Qiagen公司,Hilden)分离质粒。根据制造商对革兰氏阳性质粒制剂的推荐说明进行分离程序。通过Sanger测序(GATC公司,德国)对插入片段进行测序,并揭示了对应于甘露聚糖酶Man6、Man7和Man14的成熟部分的DNA序列。使用ClustalW序列比对进行序列比较(Thompson等人,1994)。最后,通过电穿孔将表达质粒转化到合适的芽孢杆菌生产菌株中。芽孢杆菌生产菌株在含有20g/l胰蛋白胨、10g/l酵母提取物、10g NaCl和2M蔗糖的电穿孔培养基中生长,且在OD(600nm)值为0.4时收集10ml。用含有0.272M蔗糖、1mMMgCl2和7mM KH2PO4的电穿孔缓冲液洗涤细胞,最后重悬于250μl电穿孔缓冲液中。使用以下条件进行电穿孔:1.2kV、150Ω、50μF。然后加入1ml电穿孔培养基,将细胞在37℃下培养3小时。将细胞接种在添加了20mg/l卡那霉素的LB培养板上,并在37℃下培养18小时。克隆被如上所述地验证,并用于生成用于分析测试的材料。因此,菌株在蛋白质诱导条件下以标准表达接种,并在37℃下培养30小时。收集上清液,用于分析和应用测试。基因和酶的特性如表4和表5所示。
表4:关于来自克劳氏芽孢杆菌KSM-K16、解半纤维芽孢杆菌JCM 9152和土壤枝芽孢杆菌PL205的GH5家族甘露聚糖酶编码基因的概述
基因 | 包括SP的长度(bp) | SEQ ID NO |
man6 | 975 | 9 |
man7 | 1473 | 13 |
man14 | 1449 | 17 |
表5:从来自克劳氏芽孢杆菌KSM-K16、半纤维芽孢杆菌JCM 9152和土壤枝芽孢杆菌PL205的GH5甘露聚糖酶编码基因序列推导出的氨基酸序列概述
实施例3:里氏木霉中的细菌甘露聚糖酶man6和man7的PCR克隆
在DNA的分离和酶处理(例如质粒DNA的分离、DNA的消化以生成DNA片段)、大肠杆菌转化、测序等中使用标准分子生物学方法。使用的基本方法要么如酶、试剂或试剂盒的制造商所述,要么如标准分子生物学手册(例如,Sambrook和Russell(2001))中所述。基因组DNA的分离如Raeder和Broda(1985)详细描述的进行。
分别来自克劳氏芽孢杆菌和半纤维芽孢杆菌的man6和man7也被克隆,用于在里氏木霉中表达。使用按里氏木霉密码子优化的合成基因对基因进行PCR克隆。通过使用PCR除去编码信号肽的DNA序列man6和man7,生成新的克隆位点。引物的序列在表6中表示(SEQ IDNO:21-24)。
表6:用作PCR引物以扩增解半纤维素芽孢杆菌和克劳氏芽孢杆菌甘露聚糖酶基因的寡核苷酸
(a括号中的“s”=有义链,“as”=反义链。
用表6中所述的引物且使用合成的DNA作为反应中的模板,通过PCR扩增基因。克劳氏芽孢杆菌man6和解半纤维素芽孢杆菌man7的PCR混合物分别包含:用于Phusion HF聚合酶(NEB/BioNordika公司,芬兰)的1×HF缓冲液、0.2mM dNTP混合物(Thermo FisherScientific公司,芬兰)、1μM每种引物、3%DMSO(Thermo Fisher Scientific公司)、1单位Phusion高保真聚合酶(NEB/BioNordika公司,芬兰)和50ng相应的质粒DNA。PCR反应的条件如下:在98℃下初始变性30秒,然后在98℃下进行28个10秒循环,在45/50/55/60℃中的一个温度下退火30秒,在72℃下延伸45秒,最后在72℃下延伸7分钟。
表6中描述的引物组合生成了具有所期望大小的特定DNA产物。按照制造商的说明书用GenJet Gel Extraction试剂盒(Thermo Fisher Scientific公司)从琼脂糖凝胶中分离PCR产物,用NruI和BamHI限制酶(Thermo Fisher Scientific公司)消化PCR产物并克隆到用NruI和BamHI切割的表达载体中。将连接混合物(ligation mixture)转化到大肠杆菌XL1-Blue(AH Diagnostics公司)中并涂布在含有50-100μg/ml氨苄青霉素的LB培养板上。从培养板收集几个大肠杆菌菌落,用GenJet Plasmid Miniprep试剂盒(Thermo FisherScientific公司)分离DNA。使用限制性消化筛选阳性克隆。对编码克劳氏芽孢杆菌(man6)和解半纤维素芽孢杆菌(man7)GH5甘露聚糖酶的基因(没有它们自身的信号肽编码序列)进行测序,并将质粒分别命名为pALK4274和pALK4273(详情参见实施例6)。
实施例4:合成细菌甘露聚糖酶man14的克隆
在DNA的分离和酶处理(例如质粒DNA的分离、DNA的消化以生成DNA片段)、大肠杆菌转化、测序等中使用标准分子生物学方法。使用的基本方法要么如酶、试剂或试剂盒的制造商所述,要么如标准分子生物学手册(例如,Sambrook和Russell(2001))中所述。基因组DNA的分离如Raeder和Broda(1985)详细描述的进行。
还克隆了来自土壤枝芽孢杆菌的甘露聚糖酶基因man14用于木霉属的表达。从GenScript公司订购来自土壤枝芽孢杆菌的编码GH5家族甘露聚糖酶Man14的基因,作为具有里氏木霉密码子优化的合成构建体。
将从GenScript公司获得的包含man14基因的质粒DNA重悬于无菌水中,按照制造商的说明书用NruI和BamI限制酶(Thermo Fisher Scientific公司)消化,并克隆到用NruI和BamI切割的表达载体中。将连接混合物转化到大肠杆菌XL1-Blue(AH Diagnostics公司)中,并涂布在含有50-100μg/ml氨苄青霉素的LB培养板上。从培养板收集几个大肠杆菌菌落,用GenJet Plasmid Miniprep试剂盒(Thermo Fisher Scientific公司)分离DNA。使用限制性消化筛选阳性克隆,显示出它们含有所期望的大小的插入片段。对土壤枝芽孢杆菌man14与表达质粒的融合位点进行测序,并将质粒命名为pALK4414(详情参见实施例6)。
实施例5:在芽孢杆菌中生成重组细菌GH5甘露聚糖酶蛋白
构建表达质粒,用于从克劳氏芽孢杆菌、半纤维芽孢杆菌和土壤枝芽孢杆菌生成重组GH5甘露聚糖酶(Man6、Man7和Man14)蛋白。构建的表达质粒列于表7中。重组GH5基因(man6、man7和man14)没有它们自己的信号序列,与地衣芽孢杆菌PaprE启动子和解淀粉芽孢杆菌木聚糖酶信号肽融合。通过强终止子确保转录终止,使用卡那霉素抗性标记选择转化体。转化如实施例2中所述的进行。
表7:构建表达质粒以在适当的芽孢杆菌表达菌株中生成来自克劳氏芽孢杆菌、半纤维芽孢杆菌和土壤枝芽孢杆菌的Man6、Man7和Man14重组蛋白。
甘露聚糖酶(GH5)蛋白 | 表达质粒 |
Man6 | pEV1 Man6 |
Man7 | pEV1 Man7 |
Man14 | pEV1 Man14 |
从摇瓶培养的培养上清液中分析转化体的GH5生成。将转化体从LB培养板接种到含有2%葡萄糖、6%玉米浆、1.3%(NH4)2HPO4、0.05%MgSO4·7H2O和0.5%CaCl2的摇瓶中。将pH值调节至pH 7.5。在37℃,180rpm下培养30小时后,从培养物上清液中分析转化体的GH5蛋白生成。通过SDS-PAGE分析重组蛋白的异源生成,随后进行考马斯(Coomassie)染色。
选择产量最高的转化体在实验室规模的生物反应器中培养。转化体以37℃、蛋白质诱导条件在生物反应器中培养,并且追加补料直至达到合适的产量。通过离心或过滤回收上清液用于应用测试。
实施例6:在里氏木霉中生成重组细菌GH5甘露聚糖酶蛋白
在里氏木霉中构建表达质粒,用于从克劳氏芽孢杆菌、解半纤维芽孢杆菌和土壤枝芽孢杆菌(参见实施例3和4)生成重组GH5甘露聚糖酶(Man6、Man7和Man14)蛋白。构建的表达质粒列于表8中。重组GH5基因(man6、man7和man14)不含其自身信号序列,与具有里氏木霉cel6Acbh2CBM载体和接头的里氏木霉cel7A/cbh1启动子连接,后面是Kex2蛋白酶识别位点。通过里氏木霉cel7A/cbh1终止子确保转录终止,构巢曲霉(Aspergillus nidulans)amdS标记基因用于选择转化体,如Paloheimo等人(2003)中所述。在NotI消化后,线性表达盒(图2)从载体主链分离,并被转化到里氏木霉原生质体中。使用的宿主菌株不生成四种主要的里氏木霉纤维素酶(CBHI,CBHII,EGI,EGII)中的任何一种。转化如等人(1987)所述地进行,其改进在Karhunen等人(1993)中有描述,选择乙酰胺酶作为唯一的氮源(amdS标记基因)。在选择培养板上通过单个分生孢子纯化转化体,然后使它们在PD上形成孢子。
表8:在里氏木霉中构建表达质粒,以从克劳氏芽孢杆菌、解半纤维芽孢杆菌和土壤枝芽孢杆菌生成Man6、Man7和Man14重组蛋白。表达盒的总体结构如图2所示。
甘露聚糖酶(GH5)蛋白 | 表达质粒 | 表达盒<sup>(a</sup> |
Man6 | pALK4274 | 7.0kb NotI |
Man7 | pALK4273 | 7.5kb NotI |
Man14 | pALK4414 | 7.6kb NotI |
(a通过使用NotI消化从载体主链中分离用于里氏木霉转化的表达盒。
从摇瓶培养的培养上清液中分析转化体的甘露聚糖酶生成。将转化体从PD斜面接种到含有50ml用5%KH2PO4缓冲的复合乳糖基纤维素酶诱导培养基(Joutsjoki等人,1993)的摇瓶中。在30℃、250rpm下生长7天后,从培养物上清液中分析转化体的GH5蛋白产量。通过SDS-PAGE分析重组蛋白的异源生成,随后进行考马斯染色。
选择产量最高的转化体在实验室规模的生物反应器中培养。转化体以典型的嗜温真菌培养温度和微酸性条件,在蛋白质诱导条件下,通过批量或通过追加补料型工艺在生物反应器中培养。培养一直持续到培养基糖耗尽或达到合适的产量。通过离心或过滤回收上清液用于应用测试。
实施例7:通过DNS方法测定半乳甘露聚糖酶活性
甘露聚糖酶活性(MNU)测量为在50℃和pH 7.0下在5分钟内从半乳甘露聚糖(0.3w/w-%)释放的还原糖。使用二硝基水杨酸通过分光光度法测定释放的还原性碳水化合物的量。
测定中使用的底物(0.3w/w-%)如下制备:0.6g刺槐豆胶(Sigma G-0753)在约80℃50mM pH7柠檬酸钠缓冲液(或pH7柠檬酸盐磷酸盐缓冲液)中,使用加热磁搅拌器加热至沸点。将溶液冷却并在冷室(2-8℃)中溶解过夜,同时连续搅拌,通过离心除去不溶的残余物。之后,通过缓冲液将溶液填充至200ml。将底物冷冻保存并在沸水浴中加热融化至约80℃,冷却至室温并在使用前小心混合。
通过将50g的3,5-二硝基水杨酸(Sigma D-550)溶解在约4升水中来制备测定中使用的DNS试剂。在连续磁力搅拌下,逐步加入80.0g NaOH并使其溶解。在连续搅拌下分小份加入1500g罗谢尔盐(酒石酸钾钠,Merck 8087)。将小心地加热至最高温度45℃的溶液冷却至室温并填充至5000ml。之后,将其通过Whatman 1滤纸过滤并在室温下储存在深色瓶中。
首先通过向两个试管中的每一个试管都加入1.8ml底物溶液开始反应,并使其在50℃下平衡5分钟,之后将200μl适当稀释的酶溶液加入其中一个试管中,用漩涡混合器充分混合,并在50℃下精准培养5分钟。酶空白不需要平衡或培养。通过向两个管中都加入3.0ml DNS试剂使反应终止并混合。将200μl样品溶液加入酶空白样试管中。将两个试管置于沸水浴中。煮沸恰好5分钟后,将试管置于冷却水浴中并使其冷却至室温。在540nm处测量样品的吸光度与酶空白样对比,从校准曲线读取活性并乘以稀释因子。合适的稀释样品出现0.15-0.4的吸光度差异。
通过将360mg甘露糖(SigmaM-6020,储存在干燥器中)溶解在测定缓冲液中并将其稀释成含有3、6、10和14μmol/ml甘露糖的溶液,从甘露糖原液制备标准曲线20mM。除了在50℃下培养外,标准的处理方式与样品相同。在540nm处测量吸光度与试剂空白样(含有缓冲液,而不是甘露糖的标准稀释品)。对每个系列的测定构建校准曲线。
一个甘露聚糖酶单位(MNU)定义为:在测定条件下在1秒钟内生成如下还原性碳水化合物所需的酶量,即,该还原性碳水化合物具有的还原能力与1nmol来自半乳甘露聚糖的甘露糖相对应(1MNU=1nkat)。
实施例8:Man6甘露聚糖酶的纯化
通过在4℃、4000g离心10分钟,从发酵培养基中除去细胞和固体。将10ml上清液用于蛋白质纯化。将样品通过0.44μm的PVDF膜(Millex-HV,Merck Millipore公司,Carrigtwohill,IRL)过滤。将滤液加样到在20mM HEPES pH 7中平衡的HiPrep 26/10脱盐柱(GE Healthcare公司,Uppsala,瑞典)上。然后将脱盐的样品上样到用20mM HEPES pH7预平衡的5ml HiTrap Q HP柱(GE Healthcare公司,Uppsala,瑞典)上。样品上样后,用相同缓冲液洗柱至20ml。以20mM HEPES、500mM NaCl pH7线性盐梯度,15个柱体积洗脱蛋白。收集5ml的级分并在SDS-PAGE上分析。将含有靶蛋白的级分合并,并使用Vivaspin 20,10kDaMWCO超滤装置(GE Healthcare公司)浓缩至2ml。使用用20mM MES,200mM NaCl pH6.5平衡的Superdex 75 26/60凝胶过滤柱,进一步分离被浓缩的样品。收集2ml的级分并通过SDS-PAGE分析。将含有纯甘露聚糖酶的级分合并。使用相同的规程纯化其它甘露聚糖酶,但在脱盐和离子交换步骤中改变缓冲液组成。缓冲液组合物在表9中表示。
表9:用于离子交换色谱的缓冲剂
甘露聚糖酶 | 离子交换分光光度法中使用的缓冲液 |
Man6 | 20mM HEPES pH 7 |
Man7 | 20mM HEPES pH 7 |
Man14 | 20mM MES pH 6 |
被纯化的样品纯度高于95%。
使用UV吸光度280nm测量法确定纯化样品的酶含量。通过使用ExPASy(服务器http://web.expasy.org/protparam/),基于酶的氨基酸序列计算每种甘露聚糖酶的激发系数。(Gasteiger等人,2005年)。
如实施例7中所述,将纯化样品的酶活性(MNU)测量为还原糖的释放量。
通过将纯化样品的MNU活性除以纯化酶的量来计算甘露聚糖酶的比活性(MNU/mg)。将获得的数值用于计算实施例10和11中使用的酶剂量。
甘露聚糖酶的pH曲线
使用来自Megazyme公司的β-甘露糖酶片剂测试天青蛋白交联的角豆半乳甘露聚糖(T-MNZ11/14),确定纯化的甘露聚糖酶的pH曲线,对所建议的规程进行了微小修改。已经用每种纯化的酶检查了测定的线性。该测定在pH值调节至在4和11之间的40mM伯瑞坦-罗宾森缓冲液中进行。将酶溶液在测定缓冲液中稀释,并在加入一个底物片剂之前将500μl酶溶液在50℃水浴中平衡5分钟。10分钟后,通过加入10ml 2%三羟甲基氨基甲烷(Tris)pH 12使反应终止。将反应管在室温下放置5分钟,搅拌,并将液体通过Whatman No.1纸过滤器过滤。通过测量595nm处的吸光度来量化从底物释放的蓝色染料。每种pH值下的酶活性被报告为相对活性,其中最适pH值下的活性设定为100%。pH曲线如图3所示。
通过将样品的甘露聚糖酶活性除以参比样品的甘露聚糖酶活性来计算甘露聚糖酶的相对活性(%)。在pH曲线的情况下,参比样品是最佳pH值下的样品。在温度曲线的情况下,参比样品是在最佳温度下的样品。
甘露聚糖酶的温度曲线
使用来自Megazyme公司的β-甘露糖酶片剂测试天青蛋白交联的角豆半乳甘露聚糖(T-MNZ11/14),测定纯化的甘露聚糖酶的最适温度,对所建议的规程进行了微小修改。该测定,在40mM伯瑞坦-罗宾森缓冲液pH7中,在30-90℃之间变化的温度下进行10分钟。将酶活性报告为相对活性,其中最佳温度下的活性设定为100%。温度曲线如图4所示。
甘露聚糖酶的温度和pH特性
Man6的分子量在30-35kDa之间。该酶在pH 7下的最佳温度为50℃至70℃。所述酶在50℃下在至少pH 6至pH 9的pH范围内具有最佳pH值。使用10分钟反应时间和天青蛋白交联的角豆半乳甘露聚糖作为底物,测定最佳温度和最佳pH值。
Man7的分子量在50-55kDa之间。酶在pH 7下的最佳温度为40℃至60℃。所述酶在50℃下在至少pH 7至pH 10的pH范围内具有最佳pH值。使用10分钟反应时间和天青蛋白交联的角豆半乳甘露聚糖作为底物测定最佳温度和最佳pH值。
Man14的分子量在30-40kDa之间。酶在pH 7下的最佳温度为50℃至60℃。所述酶在50℃下在至少pH 7至pH 8的pH范围内具有最佳pH值。使用10分钟反应时间和天青蛋白交联的角豆半乳甘露聚糖作为底物测定最佳温度和最佳pH值。
实施例9:与不含漂白剂的市售洗涤剂一起使用时,Man6和Man7甘露聚糖酶的去污性能
对于在芽孢杆菌(如实施例5中所述)和木霉属(如实施例6中所述)中生成的Man6和Man7甘露聚糖酶,测试了与不含漂白剂的洗涤剂一起使用时,在40℃和16°dH的水硬度下去除甘露聚糖酶敏感性标准污渍的能力,并与市售甘露聚糖酶制剂4.0L(诺维信(Novozymes)公司)进行比较。使用来自Center for test material B.V.(荷兰)的以下人工污染的测试布:带对甘露聚糖酶敏感的巧克力布丁的棉布(E-165)、带刺槐豆胶和颜料的棉布(C-S-73)和带刺槐豆胶和颜料的聚酯/棉布(PC-S-73)、以及带瓜尔胶和炭黑的棉布(C-S-43)。将织物切成6cm×6cm的小样布,并将每一种的2个小样布用于测试。
含有除甘露聚糖酶以外的所有其它酶的市售重垢液体洗涤剂A以每升洗涤水(wash liquor)4.4g的浓度使用,不含酶的市售彩色洗涤剂粉末以3.8g/l使用。在硬度为16°dH的合成自来水中制备含有洗涤剂的洗涤水。将蛋白酶16L(0.5w/w%)和淀粉酶12L(0.4w/w%)加入与市售彩色洗涤剂粉末一起使用的硬水中,液体洗涤剂已经含有淀粉酶和蛋白酶。彩色洗涤剂粉末的洗涤水的pH值约为10,液体洗涤剂的洗涤水的pH值约为8.3。
甘露聚糖酶的剂量在洗涤剂重量的0-0.2/0.25%范围内,但是为了进行评价,把剂量计算为每毫升洗涤水有多少个酶活性单位(MNU)或每升洗涤水有多少毫克活性酶蛋白(AEP)。如实施例7中所述测量活性。如实施例8中定义的,通过将酶活性除以比活性来计算每种制剂的AEP含量。对照样品含有洗涤剂溶液但不含甘露聚糖酶。
对于硬度为16°dH的合成自来水,在去离子水(Milli-Q或等效物)中制备以下储用溶液:
1000°d钙硬度的储用溶液:CaCl2·2H2O(1.02382.1000,Merck KGaA公司,德国)26.22g/l
200°d镁硬度的储用溶液:MgSO4·7H2O(1.05856.1000,Merck KGaA公司,德国)8.79g/l H2O
NaHCO3储用溶液:NaHCO3(1.06329.1000Merck KGaA公司,德国)29.6g/l
将13.3ml CaCl2溶液、13.3ml MgSO4溶液和10.0ml新制备的NaHCO3溶液以给定的顺序加入容量瓶中,用去离子水补足至1升并混合。通过络合滴定测定水的硬度,发现是正确的。
如下所述在Atlas LP-2Launder-Ometer水洗色牢度测试仪中进行去污处理。首先将水洗色牢度测试仪预热至40℃。然后将洗涤剂、250ml硬度为16°dH的合成自来水和稀释的酶(<1.0ml)加入1.2升容器中。添加污渍,将水洗色牢度测试仪在40℃下运行60分钟,转速为42rpm。之后,将小样布在流水下小心冲洗,并在室内空气中在防止日光照射的栅格上干燥过夜。
通过使用Konica Minolta CM-3610A分光光度计,使用L*a*b*颜色空间坐标(光源D65/10°,420nm切割)把颜色测量为反射率值,评价去污效果。污渍褪色,作为表示甘露聚糖酶性能(去污效率)的指标,计算为ΔL*,ΔL*指被酶处理的织物的亮度值L*减去用不含甘露聚糖酶的洗涤水(对照)处理的织物的亮度值L*。最终结果(总去污效果)显示为每种污渍的ΔL*的总和。每种污渍的颜色值是2个小样布的平均值。
用市售液体洗涤剂获得的结果在图6-7中表示。与市售甘露聚糖酶制剂4.0L相比,根据本发明的甘露聚糖酶在作为活性单位或作为活性酶蛋白添加时,与液体洗涤剂一起使用,具有类似的(Man6)或相当好的(Man7)去污性能。不论表达宿主是芽孢杆菌还是木霉属,用Man6和Man7都得到了同样的性能(图6)。
用市售色彩洗涤剂粉末获得的结果(图8-9)表明,与市售甘露聚糖酶制剂4.0L相比,根据本发明的甘露聚糖酶在作为活性单位或作为活性酶蛋白添加时,与彩色洗涤剂粉末一起使用,具有更好的去污性能。
实施例10:与含漂白剂的洗涤剂一起使用时,Man6和Man7甘露聚糖酶的去污性能
对于在芽孢杆菌中生成的Man6和Man7甘露聚糖酶(如实施例5中所述),在40℃和16°dH的水硬度下,测试了它们与市售漂白洗涤剂粉末一起使用时的去除甘露聚糖酶敏感性标准污渍的能力,并与市售甘露聚糖酶制剂4.0L(诺维信公司)进行比较。测试系统类似于实施例9中所述,但是使用了来自Center for test material B.V.(荷兰)的三种不同的人工污染的测试布:带对甘露聚糖酶敏感的巧克力布丁的棉布(E-165)、带刺槐豆胶和颜料的棉布(C-S-73)、以及带瓜尔胶和炭黑的棉布(C-S-43)。市售彩色洗涤剂粉末以每升洗涤水4.2g的浓度使用,洗涤水的pH值约为9.5。将蛋白酶16L(0.5w/w%)和淀粉酶12L(0.4w/w%)加入用于测试的硬水中,因为洗涤剂不含任何酶。
测量处理后的小样布的颜色,并将结果计算为实施例9中所述的每3种污渍的ΔL*的总和。
用市售的含漂白剂的洗涤剂得到的结果(图10)表明,与市售甘露聚糖酶4.0L相比,本发明的甘露聚糖酶(Man7)在作为活性酶蛋白添加时,具有明显更好的去污性能。与市售细菌甘露聚糖酶相比,Man6得到了至少相似的性能。
实施例11:与市售液体洗涤剂一起使用时,Man14甘露聚糖酶的去污性能
对于在芽孢杆菌中生成的Man14甘露聚糖酶(如实施例5中所述),在40℃和16°dH的水硬度下,测试了它们与市售重垢液体洗涤剂B一起使用时的去除甘露聚糖酶敏感性标准污渍的能力,并与市售甘露聚糖酶制剂4.0L(诺维信公司)进行比较。测试系统类似于实施例9中所述,但是使用了来自Center for test material B.V.(荷兰)的两种不同的人工污染的测试布:带对甘露聚糖酶敏感的巧克力布丁的棉布(E-165)、以及带刺槐豆胶和颜料的棉布(C-S-73)。市售重垢液体洗涤剂B以每升洗涤水5g的浓度使用,洗涤水的pH值约为8.3。将蛋白酶16L(0.5w/w%)和淀粉酶12L(0.4w/w%)加入用于测试的硬水中,因为洗涤剂不含任何酶。
测量处理后的小样布的颜色,并将结果计算为实施例9中所述的每两种污渍的ΔL*的总和。
用市售的含液体的洗涤剂得到的结果(图11-12)表明,与市售产品相比,在作为活性单位或作为活性酶蛋白添加时,Man14在液体洗涤剂中具有良好的性能。
实施例12:Man6和Man7甘露聚糖酶在市售液体洗涤剂中的稳定性
在从当地超市获得的OMO Color液体中测试在芽孢杆菌中生成的Man6和Man7甘露聚糖酶制剂的稳定性,并与市售甘露聚糖酶制剂4.0L进行比较。将0.5%w/w-%甘露聚糖酶制剂加入洗涤剂,样品在带有帽的塑料管中在37℃下培养5个星期。除了使用30分钟的培养时间外,通过在实施例7中描述的活性测定法以一定间隔测量了活性。结果计算为残余活性(%),通过将在特定时间点取得的样品的活性除以样品的初始活性获得。
还是在含有蛋白酶但不含甘露聚糖酶的市售液体重垢洗涤剂A中,对分别在芽孢杆菌和木霉属中生成的Man7以及在木霉属中生成的Man6的稳定性进行了测试,并与4.0L相对照。在该试验中,使用1%-(w/w)的甘露聚糖酶,样品在37℃下培养12个星期。
Omo Color中的结果(图13)表明,与4.0L相比,Man6具有比它好得多的稳定性,而Man7具有与它相似的稳定性。在与另一种市售液体洗涤剂A一起使用时,Man7和Man6(尤其是Man6)均比4.0L更稳定,如图14所示。在相同条件下在另一个测试中获得的结果表明,不管表达宿主是芽孢杆菌还是木霉属,Man6都具有相似的稳定性(数据未示出)。
稳定性实验的结果表明,即使在诸如37℃的高温下储存,根据本发明的甘露聚糖酶在洗涤剂中也稳定数个星期。与市售的液体洗涤剂中的细菌甘露聚糖酶相比,根据本发明的甘露聚糖酶(Man6和Man7)的稳定性提高了。
实施例13:在肉鸡中单独使用和与非淀粉多糖(NSP)降解酶组合使用甘露聚糖酶的效率研究
研究了本发明的重组甘露聚糖酶对肉鸡生长的影响。将包含重组甘露聚糖酶的发酵液的超滤液干燥,并以目标水平单独或与市售的基于木聚糖酶的产品组合用于颗粒状肉鸡日粮。
在没有酶的情况下、或者在通过单独添加或与标准剂量的市售木聚糖酶组合添加不同水平的本发明的重组甘露聚糖酶的情况下,饲喂基于玉米和去壳的用溶剂萃取的大豆粉的对照日粮。
肉鸡的初始重量在30g至50g之间。试验持续三到五个星期。每次处理包括至少6次重复,每次10只肉鸡。在每种情况下,分析饮食中的水分、粗蛋白、粗纤维、脂肪、灰分和酶蛋白。
准备了五种日粮:
1)不含添加的对照(基础日粮BD)
2)BD+甘露聚糖酶1-500mg/kg
3)BD+甘露聚糖酶1-1000mg/kg
4)BD+甘露聚糖酶1-500mg/kg+木聚糖酶1-10mg/kg
5)BD+木聚糖酶1-10mg/kg
每天通过目测检查动物的健康状况和死亡率。在第0、14和35天测量体重增加(BW)、进食量(F1)和饲料转化率(FCR)。FCR计算为消耗的总饲料除以同一时期的体重增加。基于与饲喂相同日粮或饲喂相同日粮但添加了木聚糖酶的那些动物进行比较,确定重组甘露聚糖酶的效果。
实施例14:速溶咖啡生产
纯的甘露聚糖是咖啡胚乳中的主要储存多糖成分,并为其带来高粘度,这对速溶咖啡的技术加工产生负面影响并且增加干燥期间的能量消耗。这些效果归因于甘露聚糖形成坚硬的、不能溶解的晶体结构,在速溶咖啡生产的浓缩步骤中加入β-甘露聚糖酶(通常与其它酶如果胶酶和纤维素酶一起加入),以降低咖啡提取物中的粘度。甘露聚糖酶也用于水解液体咖啡提取物中存在的半乳甘露聚糖,以抑制速溶咖啡冷冻干燥过程中的凝胶形成。此外,由于酶处理的使用,咖啡豆提取物可以通过低成本程序比如蒸发进行浓缩。
根据下面图15的流程图以10℃温度和0.15%d.s.的酶剂量下进行测试。
在包含不同酶(比如果胶酶和纤维素酶)的混合物中测试本发明的甘露聚糖酶。
在标准工艺条件下,咖啡提取物的粘度随时间显着增加。然而,使用含有本发明甘露聚糖酶的酶混合物显著降低了粘度,从而改进了下游加工,例如喷雾或冷冻干燥。
实施例15:菠萝加工
特别地,甘露聚糖酶可用于菠萝榨汁提取和澄清,因为菠萝含有比例较大的甘露聚糖,包括葡甘露聚糖和半乳甘露聚糖。
甘露聚糖酶有助于改善有价值的水果成分的提取,在浓缩前降低果汁的粘度,并提高过滤速率和最终产品的稳定性。
在绞肉机中将菠萝压碎,并将500g果糊加入1000ml烧杯中。在21℃下施加酶,反应时间为60分钟。然后根据挤压规程用小型Hafico压机挤压果糊:0巴2分钟-50巴2分钟-100巴2分钟-150巴2分钟-200巴1分钟-300巴1分钟-400巴1分钟。然后,将获得的果汁以4500rpm离心5分钟,分析浊度和粘度。
在酶混合物A、B和C中测试本发明的甘露聚糖酶(表10)。
在加入菠萝果糊之前,首先将酶用自来水稀释。
表10:酶混合物
应用本发明的甘露聚糖酶可以提高菠萝加工中果汁的产量并降低浊度。
实施例16:甘露聚糖酶处理大豆,用于豆浆生产
对于为了获得豆浆的大豆的酶处理,通常使用“热工艺”。对于热豆浆工艺,将干燥的大豆混合并在混合器中用沸腾自来水以1:7(浸泡的豆:水)的比例粉碎。在加入酶之前,将整个大豆浆液冷却至50℃-55℃。大豆浆液的pH值应在pH6.5附近,并可用NaHCO3调节。以1kg/t干燥大豆的剂量,将甘露聚糖酶加入浆液中,并搅拌30分钟。在反应时间结束后,使用实验室压机挤压浆液以获得最终产品:豆浆。为了确保相同的挤压曲线,规定压力以及相应的挤压时间,如表11所示。除了用于酶促反应的样品外,还制备不含任何酶的对照样品,其中酶溶液被水替代。
表11:压榨方案
压强[巴] | 0 | 50 | 100 | 300 |
时间[分钟] | 2 | 2 | 2 | 1 |
压榨后,将豆浆在微波炉中加热至沸腾以使酶反应停止。
豆浆分析:
·以克/时间为单位的产量
·用折光仪测定白利糖度,它与豆浆中的糖含量直接相关
·用NTU光度计测量果汁的浊度,NTU光度计测量比浊法浊度
·通过LAB测量法测量亮度
·用CN分析仪测定蛋白质含量(燃烧法)
·味道
用本发明的甘露聚糖酶处理的豆浆显示出产量增加,颜色更白,白利糖度增加,浊度更低,蛋白质含量更高,味道更好(去除了异味)。
实施例17:根据本发明的液体洗涤剂组合物的洗涤性能
通过使用可从CFT(Center for Testmaterials)B.V.,Vlaardingen,荷兰(“CFT”),Material-und Prüfanstalt Testmaterialien AG(联邦材料和测试机构,Testmaterials),St.Gallen,瑞士(“EMPA”)和Warwick Equest公司,Unit 55,Consett Business Park,Consett,County Durham(“Equest”)获得的标准化污渍,确定根据本发明的液体洗涤剂组合物的洗涤性能。
使用具有下列组成的液体清洗剂作为基础配方(所有值为重量百分比):
表12
洗涤剂组合物的pH值在8.2-8.6之间。
基于该基础配方,通过添加如下所示的各种酶来制备液体洗涤剂组合物1和2:
组合物1:根据SEQ ID NO:12(Man6)的酶
组合物2:根据SEQ ID NO:16(Man7)的酶
根据AISE方法如下进行洗涤:3.5kg清洁压载布,4个SBL布,Miele洗衣机,20℃和40℃短程序。
基于总蛋白质含量,以相同的量添加所有甘露聚糖酶。
液体洗涤剂的剂量比为每升洗涤水4.0克。洗涤程序为在20℃和40℃的温度下进行60分钟,水的硬度在15.5°到16.5°(德国硬度)之间。
得到的结果是用洗涤剂得到的缓解单位(remission unit)和用含有市售参比甘露聚糖酶(Mannaway 4.0L,获自诺维信公司)的洗涤剂得到的缓解单位之间的差值。因此,正的值表示与包含参比甘露聚糖酶的相同洗涤剂组合物相比,包含本发明的甘露聚糖酶的洗涤剂组合物的洗涤性能得到改善。在洗涤测试中,测试了大范围的污渍。
白度,即污渍变得亮白,通过光度法测定,作为洗涤性能的指标。使用MinoltaCM508d光谱仪装置,事先使用随装置提供的白色标准进行校准。
得到的结果是用洗涤剂得到的缓解单位和用含有酶组合的洗涤剂得到的缓解单位之间的差值。因此,正的值表示洗涤性能因洗涤剂中存在酶组合而得到改善。洗涤剂组合物中的本发明的甘露聚糖酶对于各种含有甘露聚糖的污渍都显示出性能改善。
表13
例18:根据本发明的粉末洗涤剂组合物的洗涤性能
通过使用可从CFT(Center for Testmaterials)B.V.,Vlaardingen,荷兰(“CFT”),Material-und Prüfanstalt Testmaterialien AG(联邦材料和测试机构,Testmaterials),St.Gallen,瑞士(“EMPA”)和Warwick Equest公司,Unit 55,Consett Business Park,Consett,County Durham(“Equest”)获得的标准化污渍,确定根据本发明的粉末洗涤剂组合物的洗涤性能。
使用具有下列组成的固体清洗剂作为基础配方(所有值为重量百分比):
表14
基于该基础配方,通过添加如下所示的各种酶制备固体洗涤剂组合物3和4:
组合物3:根据SEQ ID NO:12(Man6)的酶
组合物4:根据SEQ ID NO:16(Man7)的酶
根据AISE方法如下进行洗涤:3.5kg清洁压载布,4个SBL布,Miele洗衣机,20℃和40℃短程序。基于总蛋白质含量,以相同的量添加所有甘露聚糖酶。
粉末洗涤剂的剂量比为每升洗涤水3.8克。洗涤剂的组成列于表14中。洗涤程序为在20℃和40℃的温度下进行60分钟,水的硬度在15.5°到16.5°(德国硬度)之间。
白度,即污渍变得亮白,通过光度法测定,作为洗涤性能的指标。使用MinoltaCM508d光谱仪装置,事先使用随装置提供的白色标准进行校准。
得到的结果是用洗涤剂得到的缓解单位和用含有参比甘露聚糖酶(Mannaway4.0L,获自诺维信公司)的洗涤剂得到的缓解单位之间的差值。因此,正的值表示洗涤剂中的甘露聚糖酶的洗涤性能得到改善。本发明的甘露聚糖酶对表15中的几种污渍都显示出性能改善。因此,很显然,根据本发明的甘露聚糖酶与Mannaway相比显示出洗涤性能改善。
表15:20/40℃粉末
在不限制专利权利要求的范围和解释的情况下,以下列出了本文公开的一个或多个方面或实施方式的某些技术效果。一个技术效果是甘露聚糖的降解或改性。另一技术效果是提供具有良好储存稳定性的甘露聚糖酶。
前面的描述通过本发明的特定实现方式和实施方式的非限制性示例的方式,提供了发明人目前想到的用于实现本发明的最佳模式的完整且信息丰富的描述。然而,对于本领域技术人员来说清楚的是,本发明不限于上面举出的实施方式的细节,而是可以在不脱离本发明的特征的情况下使用等同手段在其它实施方式中实现它。
而且,可以有利地使用本发明的上面公开的方面和实施方式的一些特征而无需相应地使用其它特征。因此,前面的描述应该被认为仅仅是对本发明原理的说明,而不是对其的限制。因此,本发明的范围仅受所附专利权利要求的限制。
在一个实施方式中,本发明组合物的至少一种组分,与衍生出该至少一种组分的相应天然组分相比,具有不同的化学、结构或物理特性。在一个实施方式中,所述特性是以下项目中的至少一种:大小均匀、分散均匀、异构体不同、密码子简并性不同、翻译后修饰不同、甲基化不同、三级或四级结构不同、酶活性不同、亲和力不同、结合活性不同、以及免疫原性不同。
参考文献:
Gasteiger E.,Hoogland C.,Gattiker A.,Duvaud S.,Wilkins M.R.,AppelR.D.,Bairoch A.;Protein Identification and Analysis Tools on the ExPASyServer(ExPASy服务器上的蛋白质鉴定和分析工具);(In)John M.Walker(ed):TheProteomics Protocols Handbook,Humana Press(2005).pp.571-607.
Harwood,C.R(Ed.)(1990):Molecular biological methods for bacillus(芽孢杆菌的分子生物学方法).Chichester:Wiley&Sons(Modern microbiological methods现代微生物学方法).
Joutsjoki VV,Torkkeli TK,and Nevalainen KMH.(1993)Transformation ofTrichoderma reesei with the Hormoconis resinae glucoamylase P(gamP)gene:production of a heterologous glucoamylase by Trichoderma reesei(用Hormoconisresinae葡糖淀粉酶P(gamP)基因转化里氏木霉:由里氏木霉生成异源葡糖淀粉酶).Curr.Genet.24:223-228.
Karhunen T,M,Nevalainen KMH,and Suominen PL.(1993)Highfrequency one-step gene replacement in Trichoderma reesei.I.Endoglucanase Ioverproduction(里氏木霉的高频一步基因置换:I.内切葡聚糖酶I过量生成).Mol.Gen.Genet.241:515-522.
Paloheimo M,A,Kallio J,and Suominen P.(2003)Highyieldproduction of a bacterial xylanase in the filamentous fungus Trichodermareesei requires a carrier polypeptide with an intact domain structure(在丝状真菌里氏木霉中高产量生成细菌木聚糖酶需要具有完整结构域结构的载体多肽).Appl.Env.Microbiol.69:7073-7082.
M,Nevalainen H,M,Salminen E,and Knowles J.(1987)A versatiletransformation system for the cellulolytic filamentous fungus Trichodermareesei(用于纤维素分解丝状真菌里氏木霉的多功能转化系统).Gene 61:155-164.
Raeder U,and Broda P.(1985)Rapid preparation of DNAfrom filamentousfungi(从丝状真菌中快速制备DNA).Lett.Appl.Microbiol.1:17-20.
Sambrook J,and Russell DW.(2001)Molecular cloning,a laboratory manual(分子克隆,实验室手册).Cold Spring Harbor Laboratory,New York,US.
Thompson JD,Higgins DG,Gibson TJ(1994)CLUSTAL W.Improving thesensitivity of progressive multiple sequence alignment through sequenceweighting,position-specific gap penalties and weight matrix choice(通过序列加权、位置特异性空位罚分和权重矩阵选择来提高渐进多序列比对的灵敏度).NucleicAcids Research 22(22):4673-4680.DOI:10.1093/nar/22.22.4673.
Zhang XZ and Zhang Y-HP(2011)Simple,fast and high-efficiencytransformation system or directed evolution of cellulose in Bacillus subtilis(简单、快速、高效的转化系统或纤维素在枯草芽孢杆菌中的定向进化).MicrobialBiotechnology 4(1):98-105
SEQUENCE LISTING
<110> 生化酶股份有限公司(AB Enzymes)
<120> 细菌甘露聚糖酶
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gcctctgatg gtcatagcca aacacattct ggtttttata tcgaaggttc aaccctttat 120
gacgccaacg gagagccctt tgtaatgaga ggtatcaatc atggacatgc ctggtataaa 180
catgattcta acgtcgctat accagctatt gctaatcaag gagcaaatac aattcgtatt 240
gttctgtcag atggtggtca atgggcaaaa gatgatataa acacattaaa tcaagtgctc 300
gatttagcag aggaacatga gatgattgct gttgttgagg ttcacgatgc aacaggatct 360
aattctatgg ctgacttaaa tcgtgctgtc gattattgga ttgaaatgaa agacgcttta 420
attggaaaag aagatcgcgt cataattaac attgccaatg aatggtatgg agcatgggac 480
ggacaaggct gggcaaatgg ctataaggag gttattccac gtttacgaaa tgctggcttc 540
actcatacat taatggtaga tgcagctggt tggggacaat accctcaatc gattcatgat 600
tatggtcaag aggtatttaa tgctgatcct ttagcaaata cgatgttttc catccatatg 660
tatgaatatg ctggcggaaa tgcttcaatg gtacaatcta atatcgatgg tgtcgtcgat 720
caagggttag ctcttgtaat aggagaattt gggcatatgc atacggacgg agatgttgat 780
gaagcaacga tattgagcta ctcgcaacaa agaggagtcg gttggctagc ttggtcttgg 840
aaaggcaatg ggactcaatg ggaatatcta gatttatctt atgattggca aggaacaaac 900
ttaacttctt ggggaaatac cattgtccac gggcctaatg gattactcga aacatccatt 960
ccaagctcga ttttccatac cgctccaaac aatggagatc cccctcctca taacggtaat 1020
gaaacgatct tatatgattt cgaacatggc actcaaggct ggtcaggttc ttcacttctt 1080
ggaggacctt ggacgacgaa tgaatggagt acaaatggta accattcatt aaaggccgat 1140
attttcttat cagctaactc caaacatgaa ttagcaaaag ttgaaaatcg aaatttatca 1200
ggctactcta ctttacaagc cactgtccgc catgcacatt ggggaaatgt tggtaattta 1260
acggcgagaa tgtatgtaaa aacgggctca aactatagct ggtttaatgg tgatcctatc 1320
ccagtaaact cagcaaatgg tacgactgtc actttgcctc tttcatctat tccaaaccta 1380
aatgacgtaa aagaaattgg cgttgaattt attggagctt caaatagcaa tggacaaacc 1440
gccatttatt tagatcatgt aacaatccaa taa 1473
<210> 14
<211> 1395
<212> DNA
<213> Bacillus hemicellulosilyticus
<400> 14
cagacccact cgggcttcta catcgagggc tcgacgctct acgacgctaa cggcgagcct 60
tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgct 120
atccctgcta tcgctaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc 180
cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac 240
gagatgatcg ctgtcgtcga ggtccacgac gctaccggct ccaacagcat ggccgacctc 300
aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc 360
gtcatcatca acatcgctaa cgagtggtac ggcgcttggg acggccaggg ctgggccaac 420
ggctacaagg aagtcatccc tcgcctgcgc aacgctggct tcacccacac cctcatggtc 480
gacgctgccg gctggggcca gtaccctcag agcatccacg actacggcca agaggtcttc 540
aacgccgacc ctctggccaa caccatgttc tccatccaca tgtacgagta cgctggcggc 600
aacgcctcca tggtccagag caacatcgac ggcgtcgtcg accagggcct cgctctggtc 660
atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgagc 720
tactcgcagc agcgcggcgt cggctggctg gcctggtcgt ggaagggcaa cggcacccag 780
tgggagtacc tcgacctgag ctacgactgg cagggcacca acctcacgtc gtggggcaac 840
acgatcgtcc acggccctaa cggcctcctg gagacgtcca tcccttccag catctttcac 900
accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac 960
ttcgagcacg gcacgcaggg ctggtcgggc tcgtccctgc tgggcggccc ttggaccacc 1020
aacgagtggt cgaccaacgg caaccactcc ctcaaggccg acatcttcct gtccgccaac 1080
agcaagcacg agctcgccaa ggtcgagaac cgcaacctca gcggctactc gacgctgcag 1140
gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc 1200
aagacgggca gcaactactc gtggttcaac ggcgacccca tccctgtcaa ctcggctaac 1260
ggcaccaccg tcaccctccc tctgagctcg atccccaacc tcaacgacgt caaggagatc 1320
ggcgtcgagt tcatcggcgc tagcaacagc aacggccaga ccgccatcta cctggaccac 1380
gtcacgatcc agtaa 1395
<210> 15
<211> 490
<212> PRT
<213> Bacillus hemicellulosilyticus
<400> 15
Met Arg Asn Phe Gly Lys Leu Ile Val Ser Ser Cys Leu Leu Phe Ser
1 5 10 15
Phe Phe Leu Phe Ala Ser Asp Gly His Ser Gln Thr His Ser Gly Phe
20 25 30
Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala Asn Gly Glu Pro Phe Val
35 40 45
Met Arg Gly Ile Asn His Gly His Ala Trp Tyr Lys His Asp Ser Asn
50 55 60
Val Ala Ile Pro Ala Ile Ala Asn Gln Gly Ala Asn Thr Ile Arg Ile
65 70 75 80
Val Leu Ser Asp Gly Gly Gln Trp Ala Lys Asp Asp Ile Asn Thr Leu
85 90 95
Asn Gln Val Leu Asp Leu Ala Glu Glu His Glu Met Ile Ala Val Val
100 105 110
Glu Val His Asp Ala Thr Gly Ser Asn Ser Met Ala Asp Leu Asn Arg
115 120 125
Ala Val Asp Tyr Trp Ile Glu Met Lys Asp Ala Leu Ile Gly Lys Glu
130 135 140
Asp Arg Val Ile Ile Asn Ile Ala Asn Glu Trp Tyr Gly Ala Trp Asp
145 150 155 160
Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu Val Ile Pro Arg Leu Arg
165 170 175
Asn Ala Gly Phe Thr His Thr Leu Met Val Asp Ala Ala Gly Trp Gly
180 185 190
Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly Gln Glu Val Phe Asn Ala
195 200 205
Asp Pro Leu Ala Asn Thr Met Phe Ser Ile His Met Tyr Glu Tyr Ala
210 215 220
Gly Gly Asn Ala Ser Met Val Gln Ser Asn Ile Asp Gly Val Val Asp
225 230 235 240
Gln Gly Leu Ala Leu Val Ile Gly Glu Phe Gly His Met His Thr Asp
245 250 255
Gly Asp Val Asp Glu Ala Thr Ile Leu Ser Tyr Ser Gln Gln Arg Gly
260 265 270
Val Gly Trp Leu Ala Trp Ser Trp Lys Gly Asn Gly Thr Gln Trp Glu
275 280 285
Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly Thr Asn Leu Thr Ser Trp
290 295 300
Gly Asn Thr Ile Val His Gly Pro Asn Gly Leu Leu Glu Thr Ser Ile
305 310 315 320
Pro Ser Ser Ile Phe His Thr Ala Pro Asn Asn Gly Asp Pro Pro Pro
325 330 335
His Asn Gly Asn Glu Thr Ile Leu Tyr Asp Phe Glu His Gly Thr Gln
340 345 350
Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly Pro Trp Thr Thr Asn Glu
355 360 365
Trp Ser Thr Asn Gly Asn His Ser Leu Lys Ala Asp Ile Phe Leu Ser
370 375 380
Ala Asn Ser Lys His Glu Leu Ala Lys Val Glu Asn Arg Asn Leu Ser
385 390 395 400
Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg His Ala His Trp Gly Asn
405 410 415
Val Gly Asn Leu Thr Ala Arg Met Tyr Val Lys Thr Gly Ser Asn Tyr
420 425 430
Ser Trp Phe Asn Gly Asp Pro Ile Pro Val Asn Ser Ala Asn Gly Thr
435 440 445
Thr Val Thr Leu Pro Leu Ser Ser Ile Pro Asn Leu Asn Asp Val Lys
450 455 460
Glu Ile Gly Val Glu Phe Ile Gly Ala Ser Asn Ser Asn Gly Gln Thr
465 470 475 480
Ala Ile Tyr Leu Asp His Val Thr Ile Gln
485 490
<210> 16
<211> 464
<212> PRT
<213> Bacillus hemicellulosilyticus
<400> 16
Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala
1 5 10 15
Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp
20 25 30
Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly
35 40 45
Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys
50 55 60
Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His
65 70 75 80
Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser
85 90 95
Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp
100 105 110
Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu
115 120 125
Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu
130 135 140
Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val
145 150 155 160
Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly
165 170 175
Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile
180 185 190
His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ser Met Val Gln Ser Asn
195 200 205
Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe
210 215 220
Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser
225 230 235 240
Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly
245 250 255
Asn Gly Thr Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly
260 265 270
Thr Asn Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly
275 280 285
Leu Leu Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn
290 295 300
Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp
305 310 315 320
Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly
325 330 335
Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys
340 345 350
Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val
355 360 365
Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg
370 375 380
His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val
385 390 395 400
Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val
405 410 415
Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro
420 425 430
Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser
435 440 445
Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln
450 455 460
<210> 17
<211> 1449
<212> DNA
<213> Virgibacillus soli
<400> 17
atgttattct ctacttcact gtttacttct acttcaaaag cgaatgcagc aagcgggttt 60
tatgtaaacg gaaacacact ctatgacgca acaggtaccc cttttgtgat aagaggaatc 120
aatcatgctc actcttggtt taaagacgac acagcaaccg caatacctgc cattgcagca 180
actggggcga atactattag aatcgtatta tcggatggca gccaatatag tcgggatgat 240
attgatggcg tgaggaatct aatatcattg gctgaggaaa ataatctaat tgctatgtta 300
gaggtccacg atgctactgg aaaagatgat atcagctcat tagatagtgc ggcagattat 360
tggattagta taaaagaagc acttatcggc aaggaagaca aagtcctaat aaacatcgca 420
aatgaatggt acggtacttg ggatggggct agttgggcgg atggctacaa acaagtgatt 480
cccaaattaa gaaatgcagg acttaaccac acactaatag tagactctgc tggctggggg 540
caatttccgg agtccattca caattacgga aaagaagtat tcaatgctga ccccctacaa 600
aatacaatgt tctctattca tatgtatgaa tatgctggtg gggacgcttc tactgtcaaa 660
gcaaatattg acggtgtatt aaatcaaggt ctagccgtaa tcattggaga atttggacat 720
aggcatacag acggagatgt agatgaagca acaattatga attattccca agagaaaaat 780
gttggctggc tcgcatggtc gtggaaaggt aatggcatgg aatgggatta tttagactta 840
tcctatgatt gggccggaaa taacctaacc gactggggaa ataccattgt aaatagtaca 900
aacggcttaa aagctacatc tgaaataagt ccagtatttg gagatggaga tgacggtgta 960
ggcgacggtg gtcctgggga ttctaacgga actgaaacta cgctttataa cttcgaaacc 1020
gggacagaag gatggagcgg cgaaaatata gaaactggac cttggtcagt gaatgagtgg 1080
gcagcaaaag gtaaccactc tttaaaagct gatgttaatt tgggtgataa ctctgaacat 1140
tatctatacc taactcaaaa cctaaatttt agcggaaagt cacaactcac agcgactgta 1200
aagcatgctg attggggaaa cttcggggat gaaataaatg caaagttata tgtaaaaaca 1260
gaatcagatt ggcaatggtt tgatggagga attgaaaaga tcaattcttc aattggaact 1320
attataacct tagatttatc atcgctctca aacccaagtg atattaaaga agttggtgtt 1380
cagtttacgg gttcttcaaa tagttatggc ctaacagctt tatatgttga taacgttacc 1440
attaaataa 1449
<210> 18
<211> 1401
<212> DNA
<213> Virgibacillus soli
<400> 18
gcctcgggct tctacgtcaa cggcaacact ctctacgacg ccacgggcac cccatttgtc 60
atccgcggca tcaaccacgc tcactcgtgg ttcaaggacg acactgccac cgctatccct 120
gctatcgctg ctacgggcgc caacacgatc cgcatcgtcc tcagcgacgg ctcgcagtac 180
tcccgcgacg acatcgacgg cgtccgcaac ctcatctccc tggccgagga gaacaacctc 240
atcgccatgc tggaggtcca cgacgctacc ggcaaggacg acatcagctc gctggacagc 300
gccgccgact actggatctc gatcaaggaa gccctcatcg gcaaggaaga caaggtcctg 360
atcaacatcg ccaacgagtg gtacggcacc tgggacggcg ctagctgggc tgacggctac 420
aagcaggtca tccctaagct ccgcaacgcc ggcctcaacc acacgctcat cgtcgactcg 480
gctggctggg gccagttccc ggagagcatc cacaactacg gcaaggaagt cttcaacgcc 540
gaccccctgc agaacacgat gttctcgatc cacatgtacg agtacgccgg cggcgacgct 600
tccacggtca aggccaacat cgacggcgtc ctcaaccagg gcctggctgt catcatcggc 660
gagtttggcc accgccacac cgacggcgac gtcgacgagg ccaccatcat gaactacagc 720
caggagaaga acgtcggctg gctggcttgg agctggaagg gcaacggcat ggagtgggac 780
tacctcgacc tgagctacga ctgggccggc aacaacctca ccgactgggg caacacgatc 840
gtcaactcga ccaacggcct gaaggccacc tcggagatca gccctgtctt tggcgacggc 900
gacgacggcg tcggcgacgg tggccccggc gacagcaacg gcaccgagac gacgctgtac 960
aactttgaga cgggcaccga gggctggagc ggcgagaaca tcgagacggg cccttggtcg 1020
gtcaacgagt gggctgccaa gggcaaccac tccctcaagg ccgacgtcaa cctgggcgac 1080
aacagcgagc actacctcta cctgacgcag aacctcaact tctccggcaa gtcgcagctg 1140
acggctaccg tcaagcacgc tgactggggc aacttcggcg acgagatcaa cgccaagctc 1200
tacgtcaaga ccgagagcga ctggcagtgg ttcgacggtg gcatcgagaa gatcaactcc 1260
agcatcggca ccatcatcac gctcgacctg tcgtccctgt cgaacccgtc cgacatcaag 1320
gaagtcggcg tccagttcac tggctcgtct aactcttacg gcctcactgc tctttacgtc 1380
gacaacgtca ctatcaagta g 1401
<210> 19
<211> 482
<212> PRT
<213> Virgibacillus soli
<400> 19
Met Leu Phe Ser Thr Ser Leu Phe Thr Ser Thr Ser Lys Ala Asn Ala
1 5 10 15
Ala Ser Gly Phe Tyr Val Asn Gly Asn Thr Leu Tyr Asp Ala Thr Gly
20 25 30
Thr Pro Phe Val Ile Arg Gly Ile Asn His Ala His Ser Trp Phe Lys
35 40 45
Asp Asp Thr Ala Thr Ala Ile Pro Ala Ile Ala Ala Thr Gly Ala Asn
50 55 60
Thr Ile Arg Ile Val Leu Ser Asp Gly Ser Gln Tyr Ser Arg Asp Asp
65 70 75 80
Ile Asp Gly Val Arg Asn Leu Ile Ser Leu Ala Glu Glu Asn Asn Leu
85 90 95
Ile Ala Met Leu Glu Val His Asp Ala Thr Gly Lys Asp Asp Ile Ser
100 105 110
Ser Leu Asp Ser Ala Ala Asp Tyr Trp Ile Ser Ile Lys Glu Ala Leu
115 120 125
Ile Gly Lys Glu Asp Lys Val Leu Ile Asn Ile Ala Asn Glu Trp Tyr
130 135 140
Gly Thr Trp Asp Gly Ala Ser Trp Ala Asp Gly Tyr Lys Gln Val Ile
145 150 155 160
Pro Lys Leu Arg Asn Ala Gly Leu Asn His Thr Leu Ile Val Asp Ser
165 170 175
Ala Gly Trp Gly Gln Phe Pro Glu Ser Ile His Asn Tyr Gly Lys Glu
180 185 190
Val Phe Asn Ala Asp Pro Leu Gln Asn Thr Met Phe Ser Ile His Met
195 200 205
Tyr Glu Tyr Ala Gly Gly Asp Ala Ser Thr Val Lys Ala Asn Ile Asp
210 215 220
Gly Val Leu Asn Gln Gly Leu Ala Val Ile Ile Gly Glu Phe Gly His
225 230 235 240
Arg His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Met Asn Tyr Ser
245 250 255
Gln Glu Lys Asn Val Gly Trp Leu Ala Trp Ser Trp Lys Gly Asn Gly
260 265 270
Met Glu Trp Asp Tyr Leu Asp Leu Ser Tyr Asp Trp Ala Gly Asn Asn
275 280 285
Leu Thr Asp Trp Gly Asn Thr Ile Val Asn Ser Thr Asn Gly Leu Lys
290 295 300
Ala Thr Ser Glu Ile Ser Pro Val Phe Gly Asp Gly Asp Asp Gly Val
305 310 315 320
Gly Asp Gly Gly Pro Gly Asp Ser Asn Gly Thr Glu Thr Thr Leu Tyr
325 330 335
Asn Phe Glu Thr Gly Thr Glu Gly Trp Ser Gly Glu Asn Ile Glu Thr
340 345 350
Gly Pro Trp Ser Val Asn Glu Trp Ala Ala Lys Gly Asn His Ser Leu
355 360 365
Lys Ala Asp Val Asn Leu Gly Asp Asn Ser Glu His Tyr Leu Tyr Leu
370 375 380
Thr Gln Asn Leu Asn Phe Ser Gly Lys Ser Gln Leu Thr Ala Thr Val
385 390 395 400
Lys His Ala Asp Trp Gly Asn Phe Gly Asp Glu Ile Asn Ala Lys Leu
405 410 415
Tyr Val Lys Thr Glu Ser Asp Trp Gln Trp Phe Asp Gly Gly Ile Glu
420 425 430
Lys Ile Asn Ser Ser Ile Gly Thr Ile Ile Thr Leu Asp Leu Ser Ser
435 440 445
Leu Ser Asn Pro Ser Asp Ile Lys Glu Val Gly Val Gln Phe Thr Gly
450 455 460
Ser Ser Asn Ser Tyr Gly Leu Thr Ala Leu Tyr Val Asp Asn Val Thr
465 470 475 480
Ile Lys
<210> 20
<211> 466
<212> PRT
<213> Virgibacillus soli
<400> 20
Ala Ser Gly Phe Tyr Val Asn Gly Asn Thr Leu Tyr Asp Ala Thr Gly
1 5 10 15
Thr Pro Phe Val Ile Arg Gly Ile Asn His Ala His Ser Trp Phe Lys
20 25 30
Asp Asp Thr Ala Thr Ala Ile Pro Ala Ile Ala Ala Thr Gly Ala Asn
35 40 45
Thr Ile Arg Ile Val Leu Ser Asp Gly Ser Gln Tyr Ser Arg Asp Asp
50 55 60
Ile Asp Gly Val Arg Asn Leu Ile Ser Leu Ala Glu Glu Asn Asn Leu
65 70 75 80
Ile Ala Met Leu Glu Val His Asp Ala Thr Gly Lys Asp Asp Ile Ser
85 90 95
Ser Leu Asp Ser Ala Ala Asp Tyr Trp Ile Ser Ile Lys Glu Ala Leu
100 105 110
Ile Gly Lys Glu Asp Lys Val Leu Ile Asn Ile Ala Asn Glu Trp Tyr
115 120 125
Gly Thr Trp Asp Gly Ala Ser Trp Ala Asp Gly Tyr Lys Gln Val Ile
130 135 140
Pro Lys Leu Arg Asn Ala Gly Leu Asn His Thr Leu Ile Val Asp Ser
145 150 155 160
Ala Gly Trp Gly Gln Phe Pro Glu Ser Ile His Asn Tyr Gly Lys Glu
165 170 175
Val Phe Asn Ala Asp Pro Leu Gln Asn Thr Met Phe Ser Ile His Met
180 185 190
Tyr Glu Tyr Ala Gly Gly Asp Ala Ser Thr Val Lys Ala Asn Ile Asp
195 200 205
Gly Val Leu Asn Gln Gly Leu Ala Val Ile Ile Gly Glu Phe Gly His
210 215 220
Arg His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Met Asn Tyr Ser
225 230 235 240
Gln Glu Lys Asn Val Gly Trp Leu Ala Trp Ser Trp Lys Gly Asn Gly
245 250 255
Met Glu Trp Asp Tyr Leu Asp Leu Ser Tyr Asp Trp Ala Gly Asn Asn
260 265 270
Leu Thr Asp Trp Gly Asn Thr Ile Val Asn Ser Thr Asn Gly Leu Lys
275 280 285
Ala Thr Ser Glu Ile Ser Pro Val Phe Gly Asp Gly Asp Asp Gly Val
290 295 300
Gly Asp Gly Gly Pro Gly Asp Ser Asn Gly Thr Glu Thr Thr Leu Tyr
305 310 315 320
Asn Phe Glu Thr Gly Thr Glu Gly Trp Ser Gly Glu Asn Ile Glu Thr
325 330 335
Gly Pro Trp Ser Val Asn Glu Trp Ala Ala Lys Gly Asn His Ser Leu
340 345 350
Lys Ala Asp Val Asn Leu Gly Asp Asn Ser Glu His Tyr Leu Tyr Leu
355 360 365
Thr Gln Asn Leu Asn Phe Ser Gly Lys Ser Gln Leu Thr Ala Thr Val
370 375 380
Lys His Ala Asp Trp Gly Asn Phe Gly Asp Glu Ile Asn Ala Lys Leu
385 390 395 400
Tyr Val Lys Thr Glu Ser Asp Trp Gln Trp Phe Asp Gly Gly Ile Glu
405 410 415
Lys Ile Asn Ser Ser Ile Gly Thr Ile Ile Thr Leu Asp Leu Ser Ser
420 425 430
Leu Ser Asn Pro Ser Asp Ile Lys Glu Val Gly Val Gln Phe Thr Gly
435 440 445
Ser Ser Asn Ser Tyr Gly Leu Thr Ala Leu Tyr Val Asp Asn Val Thr
450 455 460
Ile Lys
465
<210> 21
<211> 60
<212> DNA
<213> Artificial Sequence
<220>
<223> primer
<400> 21
agtcaatcgc gacaagcgcc agacccactc gggcttctac atcgagggct cgacgctcta 60
<210> 22
<211> 46
<212> DNA
<213> Artificial Sequence
<220>
<223> primer
<400> 22
cgcgccggat ccttactgga tcgtgacgtg gtccaggtag atggcg 46
<210> 23
<211> 60
<212> DNA
<213> Artificial Sequence
<220>
<223> primer
<400> 23
agtcaatcgc gacaagcgcc agaacggctt ccacgtctcc ggcacggagc tcctggacaa 60
<210> 24
<211> 51
<212> DNA
<213> Artificial Sequence
<220>
<223> primer
<400> 24
cgcgccggat ccttagtcgc tcttcaggcc gttctcgccg tagacgatgc g 51
<210> 25
<211> 1846
<212> DNA
<213> Bacillus pumilus
<400> 25
atgaaaaaat gggttcaacg ggtggcttgt tttatgctgc tgatcacttt atgggcgggt 60
tggttcactc tgaccgtaaa ggcctcctcc tatgtgcaaa catctggtac acattttgta 120
ttgaacaacc acccatttta ctttgctggc acaaataatt attatttcca ttacaaatca 180
aaaaagatgg tagatgctgt ttttgacgat atgaaggcaa tggatttaaa ggttattcgt 240
atttggggat ttcacgatgg tacccctcaa gaaaactcag tcttacaatc tcgtccaggt 300
gtttatgaag aatccggttt tcaaaaacta gactatgcga tttataaagc agggcaggaa 360
ggaatcaagc tggtcatacc gctcgtgaac aattgggatg actttggcgg gatgaatcaa 420
tatgtgaagt ggtttcaggc aggatcacat gatcactttt atacagattc tcggattaaa 480
acagcttaca aaaactatgt gcgctatgta ttagagagaa ccaatacgta ctcaggtgtt 540
caatataaag atgaccctgc tattatgaca tgggagctcg ccaatgagcc gcgcgctcag 600
tcagaccctt cgggagatat actagtaaac tgggcagatg aaatgagtgc atggatcaaa 660
tcaattgact cgaatcatct tgttgctgta ggagacgaag ggttctttcg catgacaggt 720
catgatgatt ggttttacag tggaggagaa ggtgttgatt gggatcgttt gactgctctc 780
cctcatattg attatggaac ctatcattta tacccggatc actggaatca gtctgctgca 840
tggggagtga aatggatcaa agatcatatc acccgaggaa acgcaatcgg aaaacctgtt 900
gtattagaag agtttggcta tcaaaatcaa gcagcccgtc ctgatgtata tgatagctgg 960
ctgaagacaa ttgaacagct cggaggcgca ggtagccaat tttggatttt aacaagcatt 1020
caagacgatg attccctcta cccggattat gatggttttc gagttttaaa ggagagccgg 1080
gaggcaggaa ttattcgtga acacgccaaa agaatgaatg aaaagaactg atgaagaatg 1140
cctgtttata aggaacttca tttgcataaa aaaattggat atggtatagt ttttatggaa 1200
atgctaacga ttaccgagac aagagtgggg aaacccgctc ttttgtattg aacaggcaat 1260
ttttgtctcg acattattca tccgttttct gctccccctg ctcacaataa agcagggttt 1320
ttatgcagaa tgattgataa gagcgtttat cgaaagcaca aggaggaaga gaatgagcaa 1380
aaaagtagtg gatatcgtaa gcgacatggt gcagccaatt ttagatggct tacagcttga 1440
actcgttgat gttgaatttg tcaaagaggg tcaaaactgg ttccttcgcg tatttattga 1500
ctctgataaa ggcgtcgata tcgaggagtg tgccaaagtg agcgaagcct tgagcgaaaa 1560
gcttgatgag gcagatccaa ttagccaaaa ctactttctt gaagtgtcct ctcctggagc 1620
ggagcgccca ttaaagaaaa aagctgattt tgaaaaagca cttggaaaaa atgttttcat 1680
gaaaacatac gaaccaattg atggtgaaaa ggcatttgaa ggtgagctta caagctttga 1740
tggtgagatt gcaacagtga cagtgaagat caagacaaga aagaaagaga tcaatattcc 1800
atacgaaaaa attgctaacg caagattagc agtttcgttc aattaa 1846
<210> 26
<211> 376
<212> PRT
<213> Bacillus pumilus
<400> 26
Met Lys Lys Trp Val Gln Arg Val Ala Cys Phe Met Leu Leu Ile Thr
1 5 10 15
Leu Trp Ala Gly Trp Phe Thr Leu Thr Val Lys Ala Ser Ser Tyr Val
20 25 30
Gln Thr Ser Gly Thr His Phe Val Leu Asn Asn His Pro Phe Tyr Phe
35 40 45
Ala Gly Thr Asn Asn Tyr Tyr Phe His Tyr Lys Ser Lys Lys Met Val
50 55 60
Asp Ala Val Phe Asp Asp Met Lys Ala Met Asp Leu Lys Val Ile Arg
65 70 75 80
Ile Trp Gly Phe His Asp Gly Thr Pro Gln Glu Asn Ser Val Leu Gln
85 90 95
Ser Arg Pro Gly Val Tyr Glu Glu Ser Gly Phe Gln Lys Leu Asp Tyr
100 105 110
Ala Ile Tyr Lys Ala Gly Gln Glu Gly Ile Lys Leu Val Ile Pro Leu
115 120 125
Val Asn Asn Trp Asp Asp Phe Gly Gly Met Asn Gln Tyr Val Lys Trp
130 135 140
Phe Gln Ala Gly Ser His Asp His Phe Tyr Thr Asp Ser Arg Ile Lys
145 150 155 160
Thr Ala Tyr Lys Asn Tyr Val Arg Tyr Val Leu Glu Arg Thr Asn Thr
165 170 175
Tyr Ser Gly Val Gln Tyr Lys Asp Asp Pro Ala Ile Met Thr Trp Glu
180 185 190
Leu Ala Asn Glu Pro Arg Ala Gln Ser Asp Pro Ser Gly Asp Ile Leu
195 200 205
Val Asn Trp Ala Asp Glu Met Ser Ala Trp Ile Lys Ser Ile Asp Ser
210 215 220
Asn His Leu Val Ala Val Gly Asp Glu Gly Phe Phe Arg Met Thr Gly
225 230 235 240
His Asp Asp Trp Phe Tyr Ser Gly Gly Glu Gly Val Asp Trp Asp Arg
245 250 255
Leu Thr Ala Leu Pro His Ile Asp Tyr Gly Thr Tyr His Leu Tyr Pro
260 265 270
Asp His Trp Asn Gln Ser Ala Ala Trp Gly Val Lys Trp Ile Lys Asp
275 280 285
His Ile Thr Arg Gly Asn Ala Ile Gly Lys Pro Val Val Leu Glu Glu
290 295 300
Phe Gly Tyr Gln Asn Gln Ala Ala Arg Pro Asp Val Tyr Asp Ser Trp
305 310 315 320
Leu Lys Thr Ile Glu Gln Leu Gly Gly Ala Gly Ser Gln Phe Trp Ile
325 330 335
Leu Thr Ser Ile Gln Asp Asp Asp Ser Leu Tyr Pro Asp Tyr Asp Gly
340 345 350
Phe Arg Val Leu Lys Glu Ser Arg Glu Ala Gly Ile Ile Arg Glu His
355 360 365
Ala Lys Arg Met Asn Glu Lys Asn
370 375
<210> 27
<211> 1083
<212> DNA
<213> Bacillus amyloliquefaciens
<400> 27
atgctcaaaa agttcgcagt ctgtctgtct atcattttat tactcatctc agccgcccgt 60
ccgatatcgg ctcacaccgt ttaccctgtc aatcccaatg cccagcagac gacaaaagac 120
gtcatgaact ggctggcgca tttgcccaac cgttcagaaa acagggtcat gtccggtgca 180
ttcggcgggt acagcgatgt caccttttca atgacggagg aaaaccgctt gaaaaacgcg 240
acgggacagt ctcccgccat ctacggctgt gattatggga gagggtggct ggaaacatcg 300
gatatcaccg attctatcga ctacagctgc aacagcagcc tcatttcgta ctggaaaagc 360
ggcggcctcc ctcaggtcag cctgcatctc gcaaatccgg cctttccatc aggacactat 420
aaaacggcca tttcaaacag ccagtataaa aatatcctga acccttcaac tgttgaagga 480
cggcggcttg aggccttgct cagcaaaatc gccgacggcc ttactcagct gaaaaatcaa 540
ggcgtcaccg ttctgttcag gccgctgcat gagatgaacg gtgaatggtt ctggtggggg 600
ctgacaggct acaaccaaaa agacactgag agaatctcgc tgtacaaaga gctttacaag 660
aagatatacc gctatatgac agagacaaga ggattggata atcttttgtg ggtgtattcg 720
cctgatgcca acagagactt caaaacagac ttctacccag gctcatctta tgtggatatt 780
accggactgg atgcttactt caccgacccg tatgcgatat caggctatga tgaaatgctg 840
tctctgaaaa aaccgtttgc ctttgccgag accggtccgt ccggtaatat cggaagcttt 900
gattacgctg tttttatcaa tgcgatcagg caaaagtatc ccgagacaac ctactttttg 960
acatgggatg aacaattaag cccggcagcc aatcaaggcg cgcaaagcct ttatcaaaac 1020
agctggacgc tgaacaaggg cgaaatgtgg aatggcggaa ccttgacgcc gatcgcggaa 1080
taa 1083
<210> 28
<211> 360
<212> PRT
<213> Bacillus amyloliquefaciens
<400> 28
Met Leu Lys Lys Phe Ala Val Cys Leu Ser Ile Ile Leu Leu Leu Ile
1 5 10 15
Ser Ala Ala Arg Pro Ile Ser Ala His Thr Val Tyr Pro Val Asn Pro
20 25 30
Asn Ala Gln Gln Thr Thr Lys Asp Val Met Asn Trp Leu Ala His Leu
35 40 45
Pro Asn Arg Ser Glu Asn Arg Val Met Ser Gly Ala Phe Gly Gly Tyr
50 55 60
Ser Asp Val Thr Phe Ser Met Thr Glu Glu Asn Arg Leu Lys Asn Ala
65 70 75 80
Thr Gly Gln Ser Pro Ala Ile Tyr Gly Cys Asp Tyr Gly Arg Gly Trp
85 90 95
Leu Glu Thr Ser Asp Ile Thr Asp Ser Ile Asp Tyr Ser Cys Asn Ser
100 105 110
Ser Leu Ile Ser Tyr Trp Lys Ser Gly Gly Leu Pro Gln Val Ser Leu
115 120 125
His Leu Ala Asn Pro Ala Phe Pro Ser Gly His Tyr Lys Thr Ala Ile
130 135 140
Ser Asn Ser Gln Tyr Lys Asn Ile Leu Asn Pro Ser Thr Val Glu Gly
145 150 155 160
Arg Arg Leu Glu Ala Leu Leu Ser Lys Ile Ala Asp Gly Leu Thr Gln
165 170 175
Leu Lys Asn Gln Gly Val Thr Val Leu Phe Arg Pro Leu His Glu Met
180 185 190
Asn Gly Glu Trp Phe Trp Trp Gly Leu Thr Gly Tyr Asn Gln Lys Asp
195 200 205
Thr Glu Arg Ile Ser Leu Tyr Lys Glu Leu Tyr Lys Lys Ile Tyr Arg
210 215 220
Tyr Met Thr Glu Thr Arg Gly Leu Asp Asn Leu Leu Trp Val Tyr Ser
225 230 235 240
Pro Asp Ala Asn Arg Asp Phe Lys Thr Asp Phe Tyr Pro Gly Ser Ser
245 250 255
Tyr Val Asp Ile Thr Gly Leu Asp Ala Tyr Phe Thr Asp Pro Tyr Ala
260 265 270
Ile Ser Gly Tyr Asp Glu Met Leu Ser Leu Lys Lys Pro Phe Ala Phe
275 280 285
Ala Glu Thr Gly Pro Ser Gly Asn Ile Gly Ser Phe Asp Tyr Ala Val
290 295 300
Phe Ile Asn Ala Ile Arg Gln Lys Tyr Pro Glu Thr Thr Tyr Phe Leu
305 310 315 320
Thr Trp Asp Glu Gln Leu Ser Pro Ala Ala Asn Gln Gly Ala Gln Ser
325 330 335
Leu Tyr Gln Asn Ser Trp Thr Leu Asn Lys Gly Glu Met Trp Asn Gly
340 345 350
Gly Thr Leu Thr Pro Ile Ala Glu
355 360
<210> 29
<211> 1494
<212> DNA
<213> Amphibacillus xylanus
<400> 29
gtgaagttaa ctaaactaaa actattgagt agtgtatttt ttgttgtatt aactgtgtta 60
atgttgtttg tccctgggaa tattgtgaat gtaaaagctg ctaacggctt ttatgtaagc 120
gattccaatc tgtatgatgc aaatggaaat caatttgtta tgcgtggggt taatcatgcc 180
cattcatggt ataaggacac gtataccgag gcaattcctg caattgcggc tacaggagcg 240
aatactatcc gaattgtatt atctgatgga gggcaatacc aaaaagatga tataaacata 300
gtcagaaatt tgattgaaac cgcagaagcc aataatttag tcgctgtact tgaggttcat 360
gatgctactg ggtcggattc attatcggat ttgaaccggg ctgtagatta ttggattgaa 420
attaaagatg cgttaattgg taaagaagat acggtgatca taaacattgt caatgaatgg 480
tatggcactt gggatggtcg tctctgggca gatggttata aacaggcgat accgagatta 540
agagatgctg gattaacaca tacgttgatg attgatgcag caggttgggg gcaatttcct 600
agctcgatcc atcaatatgg tagagaagta tttaatgcag atcgtttagg gaatacaatg 660
ttttcgattc atatgtatga atatgctggc ggtgatgatc aaatggttag agataatatt 720
aacggtgtga tcaatcaaga cttagctcta gtgattggtg aatttggtca ttatcacaca 780
gatggcgatg ttgatgaaga tacgattttg agttacgcgg agcagacagg tgttggttgg 840
ttagcatggt catggaaagg caatggaact gagtgggagt atcttgatct atcaaatgat 900
tggggaggaa attatttaac atcttggggt gacaggattg taaatggagc aaatggatta 960
agagaaacga gtcaaattgc ttctgttttt tcaggaaaca atggcgggac tcctggaaat 1020
ggtgaggaag agactcctgg tgatgtaagt catttcgcaa acttcgagaa tggtactgaa 1080
ggttgggaag caagcaatgt atctggtgga ccttgggcaa caaatgaatg gagtgctagt 1140
ggttcatatg ctttaaaagc cgatgcgcaa ttagcatctg gaagagaaca ctatttatat 1200
cgaatcggtc cctttaattt atctgggtca acattaaacg caacggtaag gggtgctaat 1260
tgggggaatt atggatctgg tatcgacgtg aagctatacg ttaagtacgg agatggctgg 1320
acgtggagag atagtggtgt acagacaatt agagcgggag aatctattga tctatcacta 1380
gatttatcaa atgttgatcg ctcaaacatt agagaagttg gtatccagtt tattggtgga 1440
aatcattcat ctggaaaaac cgctttttat gttgatcatg tttattcaca ttag 1494
<210> 30
<211> 497
<212> PRT
<213> Amphibacillus xylanus
<400> 30
Val Lys Leu Thr Lys Leu Lys Leu Leu Ser Ser Val Phe Phe Val Val
1 5 10 15
Leu Thr Val Leu Met Leu Phe Val Pro Gly Asn Ile Val Asn Val Lys
20 25 30
Ala Ala Asn Gly Phe Tyr Val Ser Asp Ser Asn Leu Tyr Asp Ala Asn
35 40 45
Gly Asn Gln Phe Val Met Arg Gly Val Asn His Ala His Ser Trp Tyr
50 55 60
Lys Asp Thr Tyr Thr Glu Ala Ile Pro Ala Ile Ala Ala Thr Gly Ala
65 70 75 80
Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Tyr Gln Lys Asp
85 90 95
Asp Ile Asn Ile Val Arg Asn Leu Ile Glu Thr Ala Glu Ala Asn Asn
100 105 110
Leu Val Ala Val Leu Glu Val His Asp Ala Thr Gly Ser Asp Ser Leu
115 120 125
Ser Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Ile Lys Asp Ala
130 135 140
Leu Ile Gly Lys Glu Asp Thr Val Ile Ile Asn Ile Val Asn Glu Trp
145 150 155 160
Tyr Gly Thr Trp Asp Gly Arg Leu Trp Ala Asp Gly Tyr Lys Gln Ala
165 170 175
Ile Pro Arg Leu Arg Asp Ala Gly Leu Thr His Thr Leu Met Ile Asp
180 185 190
Ala Ala Gly Trp Gly Gln Phe Pro Ser Ser Ile His Gln Tyr Gly Arg
195 200 205
Glu Val Phe Asn Ala Asp Arg Leu Gly Asn Thr Met Phe Ser Ile His
210 215 220
Met Tyr Glu Tyr Ala Gly Gly Asp Asp Gln Met Val Arg Asp Asn Ile
225 230 235 240
Asn Gly Val Ile Asn Gln Asp Leu Ala Leu Val Ile Gly Glu Phe Gly
245 250 255
His Tyr His Thr Asp Gly Asp Val Asp Glu Asp Thr Ile Leu Ser Tyr
260 265 270
Ala Glu Gln Thr Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly Asn
275 280 285
Gly Thr Glu Trp Glu Tyr Leu Asp Leu Ser Asn Asp Trp Gly Gly Asn
290 295 300
Tyr Leu Thr Ser Trp Gly Asp Arg Ile Val Asn Gly Ala Asn Gly Leu
305 310 315 320
Arg Glu Thr Ser Gln Ile Ala Ser Val Phe Ser Gly Asn Asn Gly Gly
325 330 335
Thr Pro Gly Asn Gly Glu Glu Glu Thr Pro Gly Asp Val Ser His Phe
340 345 350
Ala Asn Phe Glu Asn Gly Thr Glu Gly Trp Glu Ala Ser Asn Val Ser
355 360 365
Gly Gly Pro Trp Ala Thr Asn Glu Trp Ser Ala Ser Gly Ser Tyr Ala
370 375 380
Leu Lys Ala Asp Ala Gln Leu Ala Ser Gly Arg Glu His Tyr Leu Tyr
385 390 395 400
Arg Ile Gly Pro Phe Asn Leu Ser Gly Ser Thr Leu Asn Ala Thr Val
405 410 415
Arg Gly Ala Asn Trp Gly Asn Tyr Gly Ser Gly Ile Asp Val Lys Leu
420 425 430
Tyr Val Lys Tyr Gly Asp Gly Trp Thr Trp Arg Asp Ser Gly Val Gln
435 440 445
Thr Ile Arg Ala Gly Glu Ser Ile Asp Leu Ser Leu Asp Leu Ser Asn
450 455 460
Val Asp Arg Ser Asn Ile Arg Glu Val Gly Ile Gln Phe Ile Gly Gly
465 470 475 480
Asn His Ser Ser Gly Lys Thr Ala Phe Tyr Val Asp His Val Tyr Ser
485 490 495
His
<210> 31
<211> 1767
<212> DNA
<213> Paenibacillus polymyxa
<400> 31
atgaaaaaac tactgtcttg tctcatttcg ctgtcaatgc ttgtgtatat cttaccgaca 60
atgatagtgt ccgctaacaa tgatggcgta acgaaccttg ctcttgattc aacacctagt 120
gcgcaaagtg atattatttc tgatgctgtc tacaaaatca cagctcagca ttcaggaaaa 180
agccttgagg ttgaaggcgg ttctaaagat gacggcgcga atgttcaaca atggacagat 240
aacgggaaag aacagcagaa atggagagtt gtggacgtcg gtggcggata ttacaagctc 300
atcagtcaat ctagcggaaa agcactggat gtggcaggtg gtaatacaca tgatggtgcc 360
aatgtgcaac agtggacgga caacggaaat gctcagcaaa agtggaagat catcgatgta 420
ggaggaggct attataagtt gatctcacaa agctctggaa aggcactcga cgtcgttggt 480
ggttatacgc acgacggggc caatgtgcag caatgggcag acaatggatc tgctcaacag 540
cgctggcgtt tcacacaaat tgatacaacc acggatacga cgccgccaac agcaccaacg 600
aatttacaat catcatcgaa aacaagtacc tctgtaacat tgacttggac cacaagcatt 660
gataatgtag gtgtgacagg ctatgtcatt tataatggaa cagatttggt cgggacttct 720
acaactacat cttatattgt tacaggatta acagcgaaca cttcctataa cttcactgtc 780
aaagcgaagg atgccgctgg gaatatttca gaaccatcaa atgtcttgaa agtcacaacg 840
agttcagatt cttctcaaaa cacaggtttt tatgtgaagg gcacaacatt atatgatgga 900
aacggtaatc catttgtgat gagaggaatc aatcatgcat acacatggta taaagggcaa 960
gaatcagtag caattcctgc gattgcgaaa acgggtgcaa acaccatccg gattgtctta 1020
tctgacggac agcagtggac aaaagatgat ttaagcgcgc ttcaaaattt gattacactc 1080
agtgagcaaa acaaacttgt agtgatttta gaggtgcacg acggtactgg caatgacaat 1140
gccgcagttt taaataaaat tgctgattat tggattgaaa tgaagtcagc tttaattggg 1200
aaggaaaata cagttatttt aaacatcgca aatgaatggt ttggtacatg ggatggaaac 1260
ggctgggcgc agggctacaa atcagtcata ccaaagctgc gaaatgcggg catcaaaaac 1320
acgattatgg tggatgcggc tggatgggga caatatccaa aatcgatttt tgattacgga 1380
acgcaagtgt tcgatgcaga tccgctcaag aatacgatgt tttccattca tatgtatgaa 1440
tacgcaggcg gcaacgcaga aacagtgaaa agtaatatcg acaacgtcct gaataaaaat 1500
cttgcactca tcattggaga atttggaatt aaacatacaa acggagatgt tgatgaagca 1560
acgatcatgt catacgcaca gcaaaaaggt gttgggtatc ttggctggtc atggaaagga 1620
aatggttcag gtcttgaata tttagatatg agtaacgatt gggctggcag cagttataca 1680
gagcaaggac atgccattat cgaaggacca aatggcattc gtgcaacatc aaaattatca 1740
accatttaca gcaatgggaa acaataa 1767
<210> 32
<211> 588
<212> PRT
<213> Paenibacillus polymyxa
<400> 32
Met Lys Lys Leu Leu Ser Cys Leu Ile Ser Leu Ser Met Leu Val Tyr
1 5 10 15
Ile Leu Pro Thr Met Ile Val Ser Ala Asn Asn Asp Gly Val Thr Asn
20 25 30
Leu Ala Leu Asp Ser Thr Pro Ser Ala Gln Ser Asp Ile Ile Ser Asp
35 40 45
Ala Val Tyr Lys Ile Thr Ala Gln His Ser Gly Lys Ser Leu Glu Val
50 55 60
Glu Gly Gly Ser Lys Asp Asp Gly Ala Asn Val Gln Gln Trp Thr Asp
65 70 75 80
Asn Gly Lys Glu Gln Gln Lys Trp Arg Val Val Asp Val Gly Gly Gly
85 90 95
Tyr Tyr Lys Leu Ile Ser Gln Ser Ser Gly Lys Ala Leu Asp Val Ala
100 105 110
Gly Gly Asn Thr His Asp Gly Ala Asn Val Gln Gln Trp Thr Asp Asn
115 120 125
Gly Asn Ala Gln Gln Lys Trp Lys Ile Ile Asp Val Gly Gly Gly Tyr
130 135 140
Tyr Lys Leu Ile Ser Gln Ser Ser Gly Lys Ala Leu Asp Val Val Gly
145 150 155 160
Gly Tyr Thr His Asp Gly Ala Asn Val Gln Gln Trp Ala Asp Asn Gly
165 170 175
Ser Ala Gln Gln Arg Trp Arg Phe Thr Gln Ile Asp Thr Thr Thr Asp
180 185 190
Thr Thr Pro Pro Thr Ala Pro Thr Asn Leu Gln Ser Ser Ser Lys Thr
195 200 205
Ser Thr Ser Val Thr Leu Thr Trp Thr Thr Ser Ile Asp Asn Val Gly
210 215 220
Val Thr Gly Tyr Val Ile Tyr Asn Gly Thr Asp Leu Val Gly Thr Ser
225 230 235 240
Thr Thr Thr Ser Tyr Ile Val Thr Gly Leu Thr Ala Asn Thr Ser Tyr
245 250 255
Asn Phe Thr Val Lys Ala Lys Asp Ala Ala Gly Asn Ile Ser Glu Pro
260 265 270
Ser Asn Val Leu Lys Val Thr Thr Ser Ser Asp Ser Ser Gln Asn Thr
275 280 285
Gly Phe Tyr Val Lys Gly Thr Thr Leu Tyr Asp Gly Asn Gly Asn Pro
290 295 300
Phe Val Met Arg Gly Ile Asn His Ala Tyr Thr Trp Tyr Lys Gly Gln
305 310 315 320
Glu Ser Val Ala Ile Pro Ala Ile Ala Lys Thr Gly Ala Asn Thr Ile
325 330 335
Arg Ile Val Leu Ser Asp Gly Gln Gln Trp Thr Lys Asp Asp Leu Ser
340 345 350
Ala Leu Gln Asn Leu Ile Thr Leu Ser Glu Gln Asn Lys Leu Val Val
355 360 365
Ile Leu Glu Val His Asp Gly Thr Gly Asn Asp Asn Ala Ala Val Leu
370 375 380
Asn Lys Ile Ala Asp Tyr Trp Ile Glu Met Lys Ser Ala Leu Ile Gly
385 390 395 400
Lys Glu Asn Thr Val Ile Leu Asn Ile Ala Asn Glu Trp Phe Gly Thr
405 410 415
Trp Asp Gly Asn Gly Trp Ala Gln Gly Tyr Lys Ser Val Ile Pro Lys
420 425 430
Leu Arg Asn Ala Gly Ile Lys Asn Thr Ile Met Val Asp Ala Ala Gly
435 440 445
Trp Gly Gln Tyr Pro Lys Ser Ile Phe Asp Tyr Gly Thr Gln Val Phe
450 455 460
Asp Ala Asp Pro Leu Lys Asn Thr Met Phe Ser Ile His Met Tyr Glu
465 470 475 480
Tyr Ala Gly Gly Asn Ala Glu Thr Val Lys Ser Asn Ile Asp Asn Val
485 490 495
Leu Asn Lys Asn Leu Ala Leu Ile Ile Gly Glu Phe Gly Ile Lys His
500 505 510
Thr Asn Gly Asp Val Asp Glu Ala Thr Ile Met Ser Tyr Ala Gln Gln
515 520 525
Lys Gly Val Gly Tyr Leu Gly Trp Ser Trp Lys Gly Asn Gly Ser Gly
530 535 540
Leu Glu Tyr Leu Asp Met Ser Asn Asp Trp Ala Gly Ser Ser Tyr Thr
545 550 555 560
Glu Gln Gly His Ala Ile Ile Glu Gly Pro Asn Gly Ile Arg Ala Thr
565 570 575
Ser Lys Leu Ser Thr Ile Tyr Ser Asn Gly Lys Gln
580 585
<210> 33
<211> 1470
<212> DNA
<213> Bacillus hemicellulosilyticus
<400> 33
atggatatat taagaaagtg tgtacttgta ctattggcct tactattgtt gttacctacg 60
acatcaacgg cattttctga aagcgcttct actaatgaga gagtgctaaa tttatctgat 120
ccgaatgcga cacgctatac gaaggaattg tttgcgtttc ttcaagacgt gagtggtgag 180
caagtgttgt tcgggcaaca gcatgcaaca gatgaagggt tgactctgac aggtgaagga 240
aatcgaattg gttcaactga gtcggaggtg aagaatgcag taggtgatta tccagctgtt 300
tttgggtggg atacgaacag cttggatggt cgtgaaaagc caggtacaga tgtggaaagt 360
caagagcaac gaattttaaa tacagcagaa tcgatgaaag tggcacatga attaggaggg 420
atcatcacat taagtatgca tccggataac tttgttaccg gtcattacta tggcgatacg 480
gatggtaacg tcgttcaaga aatattgcca ggtggctcca agcacaatga atttaacgct 540
tggctagata atattgctgc cctagcacat gaattagttg atgataatgg agagcctatt 600
ccggttatct tccgtccatt ccatgagcaa acaggttcgt ggttttggtg gggtgcgagc 660
acaacaactc ctgagcaata caaagcgatt tttcgatata cagtcgaata cttaagagat 720
gcaaagggtg ttcataactt tttatatgga ttctcccctg gtgcgggtcc tgctggcgat 780
ctagatcgat atttagaaac gtacccaggt gataattatg tcgatatctt aggtattgat 840
aattatgata gtaagtcaaa tgcggggtca gacgcttggt tatctggaat ggtaaaagat 900
ttagcgatga tctcgaaatt agcagaggaa agagggaagg tatcagcctt tactgaattt 960
ggatacagcg ctgaagggat gagtcaaacg ggtgatgcgt tagattggta tacacgtgtg 1020
ttaaatgcga taaaagcaga tgaagatgcg cgaaacatat cctacatgct aacgtgggct 1080
aactttgggt ggcctaataa tatatttgtt ccgtatcgtg atgtgaatgg ggatttaggt 1140
ggagatcatg agttattacc tgactttgta cagttttatg aagatgaata ctcagcattt 1200
cgtgaagata taaatgaaag tgtttacaat cgtaatgaga gttatattgt tgcggatcat 1260
gagccattta tgtatgttgt ttcccctacg acaggtacat atataacagg ctcgtctgtt 1320
gtcttacgag cgaaagtagt taacgatgag gatccgtccg ttacgtatca agtggcgggt 1380
tctgaagaag tctatgagat gactttagat gaaaatgggt attactctgc tgattatatt 1440
cctactgctc ctaagaatgg agctctgtag 1470
<210> 34
<211> 489
<212> PRT
<213> Bacillus hemicellulosilyticus
<400> 34
Met Asp Ile Leu Arg Lys Cys Val Leu Val Leu Leu Ala Leu Leu Leu
1 5 10 15
Leu Leu Pro Thr Thr Ser Thr Ala Phe Ser Glu Ser Ala Ser Thr Asn
20 25 30
Glu Arg Val Leu Asn Leu Ser Asp Pro Asn Ala Thr Arg Tyr Thr Lys
35 40 45
Glu Leu Phe Ala Phe Leu Gln Asp Val Ser Gly Glu Gln Val Leu Phe
50 55 60
Gly Gln Gln His Ala Thr Asp Glu Gly Leu Thr Leu Thr Gly Glu Gly
65 70 75 80
Asn Arg Ile Gly Ser Thr Glu Ser Glu Val Lys Asn Ala Val Gly Asp
85 90 95
Tyr Pro Ala Val Phe Gly Trp Asp Thr Asn Ser Leu Asp Gly Arg Glu
100 105 110
Lys Pro Gly Thr Asp Val Glu Ser Gln Glu Gln Arg Ile Leu Asn Thr
115 120 125
Ala Glu Ser Met Lys Val Ala His Glu Leu Gly Gly Ile Ile Thr Leu
130 135 140
Ser Met His Pro Asp Asn Phe Val Thr Gly His Tyr Tyr Gly Asp Thr
145 150 155 160
Asp Gly Asn Val Val Gln Glu Ile Leu Pro Gly Gly Ser Lys His Asn
165 170 175
Glu Phe Asn Ala Trp Leu Asp Asn Ile Ala Ala Leu Ala His Glu Leu
180 185 190
Val Asp Asp Asn Gly Glu Pro Ile Pro Val Ile Phe Arg Pro Phe His
195 200 205
Glu Gln Thr Gly Ser Trp Phe Trp Trp Gly Ala Ser Thr Thr Thr Pro
210 215 220
Glu Gln Tyr Lys Ala Ile Phe Arg Tyr Thr Val Glu Tyr Leu Arg Asp
225 230 235 240
Ala Lys Gly Val His Asn Phe Leu Tyr Gly Phe Ser Pro Gly Ala Gly
245 250 255
Pro Ala Gly Asp Leu Asp Arg Tyr Leu Glu Thr Tyr Pro Gly Asp Asn
260 265 270
Tyr Val Asp Ile Leu Gly Ile Asp Asn Tyr Asp Ser Lys Ser Asn Ala
275 280 285
Gly Ser Asp Ala Trp Leu Ser Gly Met Val Lys Asp Leu Ala Met Ile
290 295 300
Ser Lys Leu Ala Glu Glu Arg Gly Lys Val Ser Ala Phe Thr Glu Phe
305 310 315 320
Gly Tyr Ser Ala Glu Gly Met Ser Gln Thr Gly Asp Ala Leu Asp Trp
325 330 335
Tyr Thr Arg Val Leu Asn Ala Ile Lys Ala Asp Glu Asp Ala Arg Asn
340 345 350
Ile Ser Tyr Met Leu Thr Trp Ala Asn Phe Gly Trp Pro Asn Asn Ile
355 360 365
Phe Val Pro Tyr Arg Asp Val Asn Gly Asp Leu Gly Gly Asp His Glu
370 375 380
Leu Leu Pro Asp Phe Val Gln Phe Tyr Glu Asp Glu Tyr Ser Ala Phe
385 390 395 400
Arg Glu Asp Ile Asn Glu Ser Val Tyr Asn Arg Asn Glu Ser Tyr Ile
405 410 415
Val Ala Asp His Glu Pro Phe Met Tyr Val Val Ser Pro Thr Thr Gly
420 425 430
Thr Tyr Ile Thr Gly Ser Ser Val Val Leu Arg Ala Lys Val Val Asn
435 440 445
Asp Glu Asp Pro Ser Val Thr Tyr Gln Val Ala Gly Ser Glu Glu Val
450 455 460
Tyr Glu Met Thr Leu Asp Glu Asn Gly Tyr Tyr Ser Ala Asp Tyr Ile
465 470 475 480
Pro Thr Ala Pro Lys Asn Gly Ala Leu
485
<210> 35
<211> 1110
<212> DNA
<213> Bacillus alcalophilus
<400> 35
atgagaagta tgaagctttt atttgctatg tttattttag ttttttcctc ttttactttt 60
aacttagtag ttgcgcaagc tagtggacat ggacaaatgc ataaagtacc ttgggcaccc 120
caagctgaag cacctggaaa aacggctgag aatggagtct gggataaagt tagaaataat 180
cctggaaaag ccaatcctcc agcaggaaaa gtcaatggtt tttatataga tggaacaacc 240
ttatatgatg caaatggtaa gccatttgtg atgcgcggaa ttaaccacgc tcattcctgg 300
tacaagcctc acatagaaac cgcgatggag gcaattgctg atactggagc aaactccatt 360
cgtgtagttc tctcagatgg acaacagtgg accaaagatg atgttgacga agtagcaaaa 420
attatatctt tagcagaaaa acattcttta gttgctgttc ttgaggtaca tgatgcactc 480
ggaacagatg atattgaacc attacttaaa acagtcgatt actggattga gatcaaagat 540
gctttaatcg gaaaagagga caaagtaatt attaacattt ctaatgaatg gtttggttct 600
tggagcagtg aaggttgggc agaaggatat aaaaaagcaa ttcctttact aagagaggcg 660
ggtctaaaac atacacttat ggttgacgca gctgggtggg gacaatttcc tagatctatt 720
catgaaaaag gattagacgt ttttaactca gacccattaa agaatacaat gttttccatt 780
catatgtatg aatgggcagc gggtaatcct caacaagtaa aagacaatat tgacggtgtt 840
cttgaaaaga atttagctgt agtaattggt gagttcggtc atcatcacta cggaagagat 900
gttgctgttg atacgatctt aagtcattca gagaagtatg atgtaggttg gcttgcctgg 960
tcttggcacg gaaatagtgg tggtgtagag tatcttgact tagcaacaga tttttcaggg 1020
acgcaactaa ctgaatgggg agaaagaatt gtgtacggtc cgaatggttt aaaagaaact 1080
tctgaaatcg ttagtgtata caaaaaataa 1110
<210> 36
<211> 369
<212> PRT
<213> Bacillus alcalophilus
<400> 36
Met Arg Ser Met Lys Leu Leu Phe Ala Met Phe Ile Leu Val Phe Ser
1 5 10 15
Ser Phe Thr Phe Asn Leu Val Val Ala Gln Ala Ser Gly His Gly Gln
20 25 30
Met His Lys Val Pro Trp Ala Pro Gln Ala Glu Ala Pro Gly Lys Thr
35 40 45
Ala Glu Asn Gly Val Trp Asp Lys Val Arg Asn Asn Pro Gly Lys Ala
50 55 60
Asn Pro Pro Ala Gly Lys Val Asn Gly Phe Tyr Ile Asp Gly Thr Thr
65 70 75 80
Leu Tyr Asp Ala Asn Gly Lys Pro Phe Val Met Arg Gly Ile Asn His
85 90 95
Ala His Ser Trp Tyr Lys Pro His Ile Glu Thr Ala Met Glu Ala Ile
100 105 110
Ala Asp Thr Gly Ala Asn Ser Ile Arg Val Val Leu Ser Asp Gly Gln
115 120 125
Gln Trp Thr Lys Asp Asp Val Asp Glu Val Ala Lys Ile Ile Ser Leu
130 135 140
Ala Glu Lys His Ser Leu Val Ala Val Leu Glu Val His Asp Ala Leu
145 150 155 160
Gly Thr Asp Asp Ile Glu Pro Leu Leu Lys Thr Val Asp Tyr Trp Ile
165 170 175
Glu Ile Lys Asp Ala Leu Ile Gly Lys Glu Asp Lys Val Ile Ile Asn
180 185 190
Ile Ser Asn Glu Trp Phe Gly Ser Trp Ser Ser Glu Gly Trp Ala Glu
195 200 205
Gly Tyr Lys Lys Ala Ile Pro Leu Leu Arg Glu Ala Gly Leu Lys His
210 215 220
Thr Leu Met Val Asp Ala Ala Gly Trp Gly Gln Phe Pro Arg Ser Ile
225 230 235 240
His Glu Lys Gly Leu Asp Val Phe Asn Ser Asp Pro Leu Lys Asn Thr
245 250 255
Met Phe Ser Ile His Met Tyr Glu Trp Ala Ala Gly Asn Pro Gln Gln
260 265 270
Val Lys Asp Asn Ile Asp Gly Val Leu Glu Lys Asn Leu Ala Val Val
275 280 285
Ile Gly Glu Phe Gly His His His Tyr Gly Arg Asp Val Ala Val Asp
290 295 300
Thr Ile Leu Ser His Ser Glu Lys Tyr Asp Val Gly Trp Leu Ala Trp
305 310 315 320
Ser Trp His Gly Asn Ser Gly Gly Val Glu Tyr Leu Asp Leu Ala Thr
325 330 335
Asp Phe Ser Gly Thr Gln Leu Thr Glu Trp Gly Glu Arg Ile Val Tyr
340 345 350
Gly Pro Asn Gly Leu Lys Glu Thr Ser Glu Ile Val Ser Val Tyr Lys
355 360 365
Lys
<210> 37
<211> 1482
<212> DNA
<213> Bacillus sp.
<400> 37
atgaaaaaaa agttatcaca gatttatcat ttaattattt gcacacttat aataagtgtg 60
ggaataatgg ggattacaac gtccccatca gaagcaagtt caggctttta tgttgatggc 120
aatacgttat atgacgcaaa cgggcaacca tttgtcatga aaggcattaa ccatggacat 180
gcttggtata aagacaccgc ttcaacagct attcctgcca ttgcagagca aggcgcgaac 240
acgatacgta ttgttttatc agatggcggt caatgggaaa aagacgacat tgacaccgtt 300
cgtgaagtta ttgagcttgc ggagcaaaat aaaatggtgg ctgtcgttga agttcatgat 360
gccacgggcc gtgattcacg cagtgattta gatcgggcag tcgattattg gatagagatg 420
aaagatgcac ttatcggcaa agaggatact gtcattatta acattgcaaa cgaatggtat 480
ggcagttggg atggcgccgc ttgggctgat ggctacattg atgtcattcc gaagcttcgc 540
gatgccggct taacacacac cttaatggtt gatgcagcag gatgggggca atatccgcaa 600
tctattcatg attacggaca agatgtgttt aatgcagatc cgttaaaaaa tacgatattc 660
tccatccata tgtatgagta tgctggtggt gatgctaaca ctgttagatc aaatattgat 720
agagtcatag atcaagacct tgctctcgta ataggtgagt tcggtcatag acacactgat 780
ggcgatgttg atgaagatac aatccttagt tattctgaag aaactggcac aggatggctc 840
gcttggtctt ggaaaggcaa cagtgccgaa tgggattatt tagacctttc agaagattgg 900
gctggtaacc atttaactga ttggggaaat aggattgtcc acggggcaaa tggcttgcag 960
gaaacctcca aaccatccac cgtatttaca gatgataacg gtggtgcccc tgaaccgcca 1020
actactacta ccttgtatga ctttgaagga agcacacaag ggtggcatgg aagcaacgtg 1080
atgggtggcc cttggtccgt aacagaatgg ggtgcgtcag gcaactactc tttaaagggc 1140
gatgtcaatt taagctcaaa ttcttcacat gaactgtata gtgaacaaag tcgtaatcta 1200
cacggatact ctcagctaaa tgcaaccgtt cgccatgcca attggggaaa tcccggtaat 1260
ggcatgaatg caagacttta cgtgaaaacg ggctctgatt atacatggta tagcggtcct 1320
tttacacgta tcaatagctc caactcaggt acaacgttat cttttgattt aaacaacatc 1380
gaaaatagtc atcatgttag ggaaataggt gtgcaatttt cagctgcaga taatagcagc 1440
ggtcaaactg ctctatacgt tgataatgtt actttaagat aa 1482
<210> 38
<211> 493
<212> PRT
<213> Bacillus sp.
<400> 38
Met Lys Lys Lys Leu Ser Gln Ile Tyr His Leu Ile Ile Cys Thr Leu
1 5 10 15
Ile Ile Ser Val Gly Ile Met Gly Ile Thr Thr Ser Pro Ser Glu Ala
20 25 30
Ser Ser Gly Phe Tyr Val Asp Gly Asn Thr Leu Tyr Asp Ala Asn Gly
35 40 45
Gln Pro Phe Val Met Lys Gly Ile Asn His Gly His Ala Trp Tyr Lys
50 55 60
Asp Thr Ala Ser Thr Ala Ile Pro Ala Ile Ala Glu Gln Gly Ala Asn
65 70 75 80
Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Glu Lys Asp Asp
85 90 95
Ile Asp Thr Val Arg Glu Val Ile Glu Leu Ala Glu Gln Asn Lys Met
100 105 110
Val Ala Val Val Glu Val His Asp Ala Thr Gly Arg Asp Ser Arg Ser
115 120 125
Asp Leu Asp Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp Ala Leu
130 135 140
Ile Gly Lys Glu Asp Thr Val Ile Ile Asn Ile Ala Asn Glu Trp Tyr
145 150 155 160
Gly Ser Trp Asp Gly Ala Ala Trp Ala Asp Gly Tyr Ile Asp Val Ile
165 170 175
Pro Lys Leu Arg Asp Ala Gly Leu Thr His Thr Leu Met Val Asp Ala
180 185 190
Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly Gln Asp
195 200 205
Val Phe Asn Ala Asp Pro Leu Lys Asn Thr Ile Phe Ser Ile His Met
210 215 220
Tyr Glu Tyr Ala Gly Gly Asp Ala Asn Thr Val Arg Ser Asn Ile Asp
225 230 235 240
Arg Val Ile Asp Gln Asp Leu Ala Leu Val Ile Gly Glu Phe Gly His
245 250 255
Arg His Thr Asp Gly Asp Val Asp Glu Asp Thr Ile Leu Ser Tyr Ser
260 265 270
Glu Glu Thr Gly Thr Gly Trp Leu Ala Trp Ser Trp Lys Gly Asn Ser
275 280 285
Ala Glu Trp Asp Tyr Leu Asp Leu Ser Glu Asp Trp Ala Gly Asn His
290 295 300
Leu Thr Asp Trp Gly Asn Arg Ile Val His Gly Ala Asn Gly Leu Gln
305 310 315 320
Glu Thr Ser Lys Pro Ser Thr Val Phe Thr Asp Asp Asn Gly Gly Ala
325 330 335
Pro Glu Pro Pro Thr Thr Thr Thr Leu Tyr Asp Phe Glu Gly Ser Thr
340 345 350
Gln Gly Trp His Gly Ser Asn Val Met Gly Gly Pro Trp Ser Val Thr
355 360 365
Glu Trp Gly Ala Ser Gly Asn Tyr Ser Leu Lys Gly Asp Val Asn Leu
370 375 380
Ser Ser Asn Ser Ser His Glu Leu Tyr Ser Glu Gln Ser Arg Asn Leu
385 390 395 400
His Gly Tyr Ser Gln Leu Asn Ala Thr Val Arg His Ala Asn Trp Gly
405 410 415
Asn Pro Gly Asn Gly Met Asn Ala Arg Leu Tyr Val Lys Thr Gly Ser
420 425 430
Asp Tyr Thr Trp Tyr Ser Gly Pro Phe Thr Arg Ile Asn Ser Ser Asn
435 440 445
Ser Gly Thr Thr Leu Ser Phe Asp Leu Asn Asn Ile Glu Asn Ser His
450 455 460
His Val Arg Glu Ile Gly Val Gln Phe Ser Ala Ala Asp Asn Ser Ser
465 470 475 480
Gly Gln Thr Ala Leu Tyr Val Asp Asn Val Thr Leu Arg
485 490
<210> 39
<211> 1551
<212> DNA
<213> Bacillus circulans
<400> 39
atggggtggt ttttagtgat tttacgcaag tggttgattg cttttgtcgc atttttactg 60
atgttctcgt ggactggaca acttacgaac aaagcacatg ctgcaagcgg attttatgta 120
agcggtacca aattattgga tgctacagga caaccatttg tgatgcgagg agtcaatcat 180
gcgcacacat ggtataaaga tcaactatcc accgcaatac cagccattgc taaaacaggt 240
gccaacacga tacgtattgt actggcgaat ggacacaaat ggacgcttga tgatgtaaac 300
accgtcaaca atattctcac cctctgtgaa caaaacaaac taattgccgt tttggaagta 360
catgacgcta caggaagcga tagtctttcc gatttagaca acgccgttaa ttactggatt 420
ggtattaaaa gcgcgttgat cggcaaggaa gaccgtgtaa tcattaatat agctaacgag 480
tggtacggaa catgggatgg agtcgcctgg gctaatggtt ataagcaagc catacccaaa 540
ctgcgtaatg ctggtctaac tcatacgctg attgttgact ccgctggatg gggacaatat 600
ccagattcgg tcaaaaatta tgggacagaa gtactgaatg cagacccgtt aaaaaacaca 660
gtattctcta tccatatgta tgaatatgct gggggcaatg caagtaccgt caaatccaat 720
attgacggtg tgctgaacaa gaatcttgca ctgattatcg gcgaatttgg tggacaacat 780
acaaacggtg atgtggatga agccaccatt atgagttatt cccaagagaa gggagtcggc 840
tggttggctt ggtcctggaa gggaaatagc agtgatttgg cttatctcga tatgacaaat 900
gattgggctg gtaactccct cacctcgttc ggtaataccg tagtgaatgg cagtaacggc 960
attaaagcaa cttctgtgtt atccggcatt tttggaggtg ttacgccaac ctcaagccct 1020
acttctacac ctacatctac gccaacctca actcctactc ctacgccaag tccgaccccg 1080
agtccaggta ataacgggac gatcttatat gatttcgaaa caggaactca aggctggtcg 1140
ggaaacaata tttcgggagg cccatgggtc accaatgaat ggaaagcaac gggagcgcaa 1200
actctcaaag ccgatgtctc cttacaatcc aattccacgc atagtctata tataacctct 1260
aatcaaaatc tgtctggaaa aagcagtctg aaagcaacgg ttaagcatgc gaactggggc 1320
aatatcggca acgggattta tgcaaaacta tacgtaaaga ccgggtccgg gtggacatgg 1380
tacgattccg gagagaatct gattcagtca aacgacggta ccattttgac actatccctc 1440
agcggcattt cgaatttgtc ctcagtcaaa gaaattgggg tagaattccg cgcctcctca 1500
aacagtagtg gccaatcagc tatttatgta gatagtgtta gtctgcaata a 1551
<210> 40
<211> 516
<212> PRT
<213> Bacillus circulans
<400> 40
Met Gly Trp Phe Leu Val Ile Leu Arg Lys Trp Leu Ile Ala Phe Val
1 5 10 15
Ala Phe Leu Leu Met Phe Ser Trp Thr Gly Gln Leu Thr Asn Lys Ala
20 25 30
His Ala Ala Ser Gly Phe Tyr Val Ser Gly Thr Lys Leu Leu Asp Ala
35 40 45
Thr Gly Gln Pro Phe Val Met Arg Gly Val Asn His Ala His Thr Trp
50 55 60
Tyr Lys Asp Gln Leu Ser Thr Ala Ile Pro Ala Ile Ala Lys Thr Gly
65 70 75 80
Ala Asn Thr Ile Arg Ile Val Leu Ala Asn Gly His Lys Trp Thr Leu
85 90 95
Asp Asp Val Asn Thr Val Asn Asn Ile Leu Thr Leu Cys Glu Gln Asn
100 105 110
Lys Leu Ile Ala Val Leu Glu Val His Asp Ala Thr Gly Ser Asp Ser
115 120 125
Leu Ser Asp Leu Asp Asn Ala Val Asn Tyr Trp Ile Gly Ile Lys Ser
130 135 140
Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu
145 150 155 160
Trp Tyr Gly Thr Trp Asp Gly Val Ala Trp Ala Asn Gly Tyr Lys Gln
165 170 175
Ala Ile Pro Lys Leu Arg Asn Ala Gly Leu Thr His Thr Leu Ile Val
180 185 190
Asp Ser Ala Gly Trp Gly Gln Tyr Pro Asp Ser Val Lys Asn Tyr Gly
195 200 205
Thr Glu Val Leu Asn Ala Asp Pro Leu Lys Asn Thr Val Phe Ser Ile
210 215 220
His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ser Thr Val Lys Ser Asn
225 230 235 240
Ile Asp Gly Val Leu Asn Lys Asn Leu Ala Leu Ile Ile Gly Glu Phe
245 250 255
Gly Gly Gln His Thr Asn Gly Asp Val Asp Glu Ala Thr Ile Met Ser
260 265 270
Tyr Ser Gln Glu Lys Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly
275 280 285
Asn Ser Ser Asp Leu Ala Tyr Leu Asp Met Thr Asn Asp Trp Ala Gly
290 295 300
Asn Ser Leu Thr Ser Phe Gly Asn Thr Val Val Asn Gly Ser Asn Gly
305 310 315 320
Ile Lys Ala Thr Ser Val Leu Ser Gly Ile Phe Gly Gly Val Thr Pro
325 330 335
Thr Ser Ser Pro Thr Ser Thr Pro Thr Ser Thr Pro Thr Ser Thr Pro
340 345 350
Thr Pro Thr Pro Ser Pro Thr Pro Ser Pro Gly Asn Asn Gly Thr Ile
355 360 365
Leu Tyr Asp Phe Glu Thr Gly Thr Gln Gly Trp Ser Gly Asn Asn Ile
370 375 380
Ser Gly Gly Pro Trp Val Thr Asn Glu Trp Lys Ala Thr Gly Ala Gln
385 390 395 400
Thr Leu Lys Ala Asp Val Ser Leu Gln Ser Asn Ser Thr His Ser Leu
405 410 415
Tyr Ile Thr Ser Asn Gln Asn Leu Ser Gly Lys Ser Ser Leu Lys Ala
420 425 430
Thr Val Lys His Ala Asn Trp Gly Asn Ile Gly Asn Gly Ile Tyr Ala
435 440 445
Lys Leu Tyr Val Lys Thr Gly Ser Gly Trp Thr Trp Tyr Asp Ser Gly
450 455 460
Glu Asn Leu Ile Gln Ser Asn Asp Gly Thr Ile Leu Thr Leu Ser Leu
465 470 475 480
Ser Gly Ile Ser Asn Leu Ser Ser Val Lys Glu Ile Gly Val Glu Phe
485 490 495
Arg Ala Ser Ser Asn Ser Ser Gly Gln Ser Ala Ile Tyr Val Asp Ser
500 505 510
Val Ser Leu Gln
515
<210> 41
<211> 984
<212> DNA
<213> Paenibacillus sp.
<400> 41
atgagacaac ttttagcaaa aggtatttta gctgcactgg tcatgatgtt agcgatgtat 60
ggattgggga atctctcttc taaagcttcg gctgcaacag gtttttatgt aagcggtacc 120
actctatatg attctactgg taaacctttt gtaatgcgcg gtgtcaatca ttcgcatacc 180
tggttcaaaa atgatctaaa tgcagccatc cctgctattg ccaaaacagg tgcaaataca 240
gtacgtatcg ttttatctaa tggtgttcag tatactagag atgatgtaaa ctcagtcaaa 300
aatattattt ccctggttaa ccaaaacaaa atgattgctg ttcttgaggt gcatgatgct 360
accggtaaag acgattacgc ttctcttgat gccgctgtaa actactggat cagcatcaaa 420
gatgccttga ttggcaagga agatcgagtc attgttaata ttgccaatga atggtacggt 480
acatggaatg gcagtgcttg ggcagatggt tataagcagg ctattcccaa actaagaaat 540
gcaggcatca aaaacacttt aatcgttgat gccgccggct ggggacaatg tcctcaatcg 600
atcgttgatt acgggcaaag tgtatttgca gcagattcgc ttaaaaatac aattttctct 660
attcacatgt atgaatatgc aggcggtaca gatgcgatcg tcaaaagcaa tatggaaaat 720
gtactgaaca aaggacttcc tttgatcatc ggtgaatttg gcgggcagca tacaaacggc 780
gatgtagatg aacatgcaat tatgcgttat ggtcagcaaa aaggtgtagg ttggctggca 840
tggtcgtggt atggcaacaa tagtgaactc agttatctgg atttggctac aggtcccgcc 900
ggtagtctga caagtatcgg caatacgatt gtaaatgatc catatggtat caaagctacc 960
tcgaaaaaag cgggtatctt ctaa 984
<210> 42
<211> 327
<212> PRT
<213> Paenibacillus sp.
<400> 42
Met Arg Gln Leu Leu Ala Lys Gly Ile Leu Ala Ala Leu Val Met Met
1 5 10 15
Leu Ala Met Tyr Gly Leu Gly Asn Leu Ser Ser Lys Ala Ser Ala Ala
20 25 30
Thr Gly Phe Tyr Val Ser Gly Thr Thr Leu Tyr Asp Ser Thr Gly Lys
35 40 45
Pro Phe Val Met Arg Gly Val Asn His Ser His Thr Trp Phe Lys Asn
50 55 60
Asp Leu Asn Ala Ala Ile Pro Ala Ile Ala Lys Thr Gly Ala Asn Thr
65 70 75 80
Val Arg Ile Val Leu Ser Asn Gly Val Gln Tyr Thr Arg Asp Asp Val
85 90 95
Asn Ser Val Lys Asn Ile Ile Ser Leu Val Asn Gln Asn Lys Met Ile
100 105 110
Ala Val Leu Glu Val His Asp Ala Thr Gly Lys Asp Asp Tyr Ala Ser
115 120 125
Leu Asp Ala Ala Val Asn Tyr Trp Ile Ser Ile Lys Asp Ala Leu Ile
130 135 140
Gly Lys Glu Asp Arg Val Ile Val Asn Ile Ala Asn Glu Trp Tyr Gly
145 150 155 160
Thr Trp Asn Gly Ser Ala Trp Ala Asp Gly Tyr Lys Gln Ala Ile Pro
165 170 175
Lys Leu Arg Asn Ala Gly Ile Lys Asn Thr Leu Ile Val Asp Ala Ala
180 185 190
Gly Trp Gly Gln Cys Pro Gln Ser Ile Val Asp Tyr Gly Gln Ser Val
195 200 205
Phe Ala Ala Asp Ser Leu Lys Asn Thr Ile Phe Ser Ile His Met Tyr
210 215 220
Glu Tyr Ala Gly Gly Thr Asp Ala Ile Val Lys Ser Asn Met Glu Asn
225 230 235 240
Val Leu Asn Lys Gly Leu Pro Leu Ile Ile Gly Glu Phe Gly Gly Gln
245 250 255
His Thr Asn Gly Asp Val Asp Glu His Ala Ile Met Arg Tyr Gly Gln
260 265 270
Gln Lys Gly Val Gly Trp Leu Ala Trp Ser Trp Tyr Gly Asn Asn Ser
275 280 285
Glu Leu Ser Tyr Leu Asp Leu Ala Thr Gly Pro Ala Gly Ser Leu Thr
290 295 300
Ser Ile Gly Asn Thr Ile Val Asn Asp Pro Tyr Gly Ile Lys Ala Thr
305 310 315 320
Ser Lys Lys Ala Gly Ile Phe
325
<210> 43
<211> 981
<212> DNA
<213> Bacillus circulans
<400> 43
atggccaagt tgcaaaaggg tacaatctta acagtcattg cagcactgat gtttgtcatt 60
ttggggagcg cggcgcccaa agccgcagca gctacaggtt tttacgtgaa tggaggcaaa 120
ttgtacgatt ctacgggtaa accattttac atgaggggta tcaatcatgg gcactcctgg 180
tttaaaaatg atttgaacac ggctatccct gcgatcgcaa aaacgggtgc caatacggta 240
cgaattgttt tatcaaacgg tacacaatac accaaggatg atctgaattc cgtaaaaaac 300
atcattaatg tcgtaaatgc aaacaagatg attgctgtgc ttgaagtaca cgatgccact 360
gggaaagatg acttcaactc gttggatgca gcggtcaact actggataag catcaaagaa 420
gcactgatcg ggaaggaaga tcgggttatt gtaaacattg caaacgagtg gtacggaaca 480
tggaacggaa gcgcgtgggc tgacgggtac aaaaaagcta ttccgaaatt aagagatgcg 540
ggtattaaaa ataccttgat tgtagatgca gcaggctggg gtcagtaccc tcaatcgatc 600
gtcgattacg gacaaagcgt attcgccgcg gattcacaga aaaatacggc gttttccatt 660
cacatgtatg agtatgcagg caaggatgcg gccaccgtca aatccaatat ggaaaatgtg 720
ctgaataagg ggctggcctt aatcattggt gagttcggag gatatcacac caatggagat 780
gtcgatgaat atgcaatcat gaaatatggt ctggaaaaag gggtaggatg gcttgcatgg 840
tcttggtacg gtaatagctc tggattaaac tatcttgatt tggcaacagg acctaacggc 900
agtttgacga gctatggtaa tacggttgtc aatgatactt acggaattaa aaatacgtcc 960
caaaaagcgg gaatctttta a 981
<210> 44
<211> 326
<212> PRT
<213> Bacillus circulans
<400> 44
Met Ala Lys Leu Gln Lys Gly Thr Ile Leu Thr Val Ile Ala Ala Leu
1 5 10 15
Met Phe Val Ile Leu Gly Ser Ala Ala Pro Lys Ala Ala Ala Ala Thr
20 25 30
Gly Phe Tyr Val Asn Gly Gly Lys Leu Tyr Asp Ser Thr Gly Lys Pro
35 40 45
Phe Tyr Met Arg Gly Ile Asn His Gly His Ser Trp Phe Lys Asn Asp
50 55 60
Leu Asn Thr Ala Ile Pro Ala Ile Ala Lys Thr Gly Ala Asn Thr Val
65 70 75 80
Arg Ile Val Leu Ser Asn Gly Thr Gln Tyr Thr Lys Asp Asp Leu Asn
85 90 95
Ser Val Lys Asn Ile Ile Asn Val Val Asn Ala Asn Lys Met Ile Ala
100 105 110
Val Leu Glu Val His Asp Ala Thr Gly Lys Asp Asp Phe Asn Ser Leu
115 120 125
Asp Ala Ala Val Asn Tyr Trp Ile Ser Ile Lys Glu Ala Leu Ile Gly
130 135 140
Lys Glu Asp Arg Val Ile Val Asn Ile Ala Asn Glu Trp Tyr Gly Thr
145 150 155 160
Trp Asn Gly Ser Ala Trp Ala Asp Gly Tyr Lys Lys Ala Ile Pro Lys
165 170 175
Leu Arg Asp Ala Gly Ile Lys Asn Thr Leu Ile Val Asp Ala Ala Gly
180 185 190
Trp Gly Gln Tyr Pro Gln Ser Ile Val Asp Tyr Gly Gln Ser Val Phe
195 200 205
Ala Ala Asp Ser Gln Lys Asn Thr Ala Phe Ser Ile His Met Tyr Glu
210 215 220
Tyr Ala Gly Lys Asp Ala Ala Thr Val Lys Ser Asn Met Glu Asn Val
225 230 235 240
Leu Asn Lys Gly Leu Ala Leu Ile Ile Gly Glu Phe Gly Gly Tyr His
245 250 255
Thr Asn Gly Asp Val Asp Glu Tyr Ala Ile Met Lys Tyr Gly Leu Glu
260 265 270
Lys Gly Val Gly Trp Leu Ala Trp Ser Trp Tyr Gly Asn Ser Ser Gly
275 280 285
Leu Asn Tyr Leu Asp Leu Ala Thr Gly Pro Asn Gly Ser Leu Thr Ser
290 295 300
Tyr Gly Asn Thr Val Val Asn Asp Thr Tyr Gly Ile Lys Asn Thr Ser
305 310 315 320
Gln Lys Ala Gly Ile Phe
325
<210> 45
<211> 1110
<212> DNA
<213> Bacillus nealsonii
<400> 45
atggttgtga aaaaattatc aagttttatt ctaattttac tgttagttac ttctgctttg 60
tttattactg attcaaaagc aagtgctgct tcgggatttt atgtaagcgg taccacttta 120
tatgatgcaa cgggtaaacc gtttactatg agaggtgtaa atcatgctca ttcttggttt 180
aaagaagatt cagcagctgc tattccagca atagcagcaa ctggagcaaa cacagtaaga 240
attgttttat ctgatggtgg acaatacacc aaagatgata ttaatactgt taaaagcctt 300
ttgtcattgg cagaaaaaat aaacttgcat tctggagtca tgacgcacag aaaagacgat 360
gtggaatctt taaatcgtgc agtcgattat tggatcagct taaaagacac attgataggc 420
aaagaagata aagtgataat aaacattgcg aatgaatggt atggtacttg ggatggtgcg 480
gcatgggcag ctggttataa acaagctatt ccaaagttac ggaatgcagg cttaaatcat 540
actctaataa ttgattctgc tggatgggga caatacccag cttccattca taattatgga 600
aaagaggtat ttaatgcgga tccattgaaa aatacaatgt tctccataca tatgtatgag 660
tacgctggtg gggatgcagc aactgttaag tcaaatattg atggtgtctt aaaccaagga 720
ttagctttaa taataggaga gtttggacaa aaacatacaa atggagatgt agatgaagca 780
accatcatga gttattcaca gcaaaaaaat atcggttggc ttgcatggtc ttggaaagga 840
aatagcacag attggagcta tctggattta agcaacgatt ggtctggtaa cagtttaact 900
gattggggta atacggttgt taatggggca aatgggttaa aagccacttc aaaactaagc 960
ggagtattcg gtagctcagc aggaacaaat aatatattgt atgattttga aagcggtaat 1020
caaaactgga ctggatcaaa tatcgcgggt ggaccttgga acgaattcaa gcttgatatc 1080
attcaggacg agcctcagac tccagcgtaa 1110
<210> 46
<211> 369
<212> PRT
<213> Bacillus nealsonii
<400> 46
Met Val Val Lys Lys Leu Ser Ser Phe Ile Leu Ile Leu Leu Leu Val
1 5 10 15
Thr Ser Ala Leu Phe Ile Thr Asp Ser Lys Ala Ser Ala Ala Ser Gly
20 25 30
Phe Tyr Val Ser Gly Thr Thr Leu Tyr Asp Ala Thr Gly Lys Pro Phe
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Thr Met Arg Gly Val Asn His Ala His Ser Trp Phe Lys Glu Asp Ser
50 55 60
Ala Ala Ala Ile Pro Ala Ile Ala Ala Thr Gly Ala Asn Thr Val Arg
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Ile Val Leu Ser Asp Gly Gly Gln Tyr Thr Lys Asp Asp Ile Asn Thr
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Val Lys Ser Leu Leu Ser Leu Ala Glu Lys Ile Asn Leu His Ser Gly
100 105 110
Val Met Thr His Arg Lys Asp Asp Val Glu Ser Leu Asn Arg Ala Val
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Asp Tyr Trp Ile Ser Leu Lys Asp Thr Leu Ile Gly Lys Glu Asp Lys
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Val Ile Ile Asn Ile Ala Asn Glu Trp Tyr Gly Thr Trp Asp Gly Ala
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Ala Trp Ala Ala Gly Tyr Lys Gln Ala Ile Pro Lys Leu Arg Asn Ala
165 170 175
Gly Leu Asn His Thr Leu Ile Ile Asp Ser Ala Gly Trp Gly Gln Tyr
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Pro Ala Ser Ile His Asn Tyr Gly Lys Glu Val Phe Asn Ala Asp Pro
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Asp Ala Ala Thr Val Lys Ser Asn Ile Asp Gly Val Leu Asn Gln Gly
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Leu Ala Leu Ile Ile Gly Glu Phe Gly Gln Lys His Thr Asn Gly Asp
245 250 255
Val Asp Glu Ala Thr Ile Met Ser Tyr Ser Gln Gln Lys Asn Ile Gly
260 265 270
Trp Leu Ala Trp Ser Trp Lys Gly Asn Ser Thr Asp Trp Ser Tyr Leu
275 280 285
Asp Leu Ser Asn Asp Trp Ser Gly Asn Ser Leu Thr Asp Trp Gly Asn
290 295 300
Thr Val Val Asn Gly Ala Asn Gly Leu Lys Ala Thr Ser Lys Leu Ser
305 310 315 320
Gly Val Phe Gly Ser Ser Ala Gly Thr Asn Asn Ile Leu Tyr Asp Phe
325 330 335
Glu Ser Gly Asn Gln Asn Trp Thr Gly Ser Asn Ile Ala Gly Gly Pro
340 345 350
Trp Asn Glu Phe Lys Leu Asp Ile Ile Gln Asp Glu Pro Gln Thr Pro
355 360 365
Ala
<210> 47
<211> 984
<212> DNA
<213> Bacillus circulans
<400> 47
atgatgttga tatggatgca gggatggaag tctattctag tcgcgatctt ggcgtgtgtg 60
tcagtaggcg gtgggcttcc tagtccagaa gcagccacag gattttatgt aaacggtacc 120
aagctgtatg attcaacggg caaggccttt gtgatgaggg gtgtaaatca tccccacacc 180
tggtacaaga atgatctgaa cgcggctatt ccggctatcg cgcaaacggg agccaatacc 240
gtacgagtcg tcttgtcgaa cgggtcgcaa tggaccaagg atgacctgaa ctccgtcaac 300
agtatcatct cgctggtgtc gcagcatcaa atgatagccg ttctggaggt gcatgatgcg 360
acaggcaaag atgagtatgc ttcccttgaa gcggccgtcg actattggat cagcatcaaa 420
ggggcattga tcggaaaaga agaccgcgtc atcgtcaata ttgctaatga atggtatgga 480
aattggaaca gcagcggatg ggccgatggt tataagcagg ccattcccaa attaagaaac 540
gcgggcatta agaatacgtt gatcgttgat gcagcgggat gggggcaata cccgcaatcc 600
atcgtggatg agggggccgc ggtatttgct tccgatcaac tgaagaatac ggtattctcc 660
atccatatgt atgagtatgc cggtaaggat gccgctacgg tgaaaacgaa tatggacgat 720
gttttaaaca aaggattgcc tttaatcatt ggggagttcg gcggctatca tcaaggtgcc 780
gatgtcgatg agattgctat tatgaagtac ggacagcaga aggaagtggg ctggctggct 840
tggtcctggt acggaaacag cccggagctg aacgatttgg atctggctgc agggccaagc 900
ggaaacctga ccggctgggg aaacacggtg gttcatggaa ccgacgggat tcagcaaacc 960
tccaagaaag cgggcattta ttaa 984
<210> 48
<211> 327
<212> PRT
<213> Bacillus circulans
<400> 48
Met Met Leu Ile Trp Met Gln Gly Trp Lys Ser Ile Leu Val Ala Ile
1 5 10 15
Leu Ala Cys Val Ser Val Gly Gly Gly Leu Pro Ser Pro Glu Ala Ala
20 25 30
Thr Gly Phe Tyr Val Asn Gly Thr Lys Leu Tyr Asp Ser Thr Gly Lys
35 40 45
Ala Phe Val Met Arg Gly Val Asn His Pro His Thr Trp Tyr Lys Asn
50 55 60
Asp Leu Asn Ala Ala Ile Pro Ala Ile Ala Gln Thr Gly Ala Asn Thr
65 70 75 80
Val Arg Val Val Leu Ser Asn Gly Ser Gln Trp Thr Lys Asp Asp Leu
85 90 95
Asn Ser Val Asn Ser Ile Ile Ser Leu Val Ser Gln His Gln Met Ile
100 105 110
Ala Val Leu Glu Val His Asp Ala Thr Gly Lys Asp Glu Tyr Ala Ser
115 120 125
Leu Glu Ala Ala Val Asp Tyr Trp Ile Ser Ile Lys Gly Ala Leu Ile
130 135 140
Gly Lys Glu Asp Arg Val Ile Val Asn Ile Ala Asn Glu Trp Tyr Gly
145 150 155 160
Asn Trp Asn Ser Ser Gly Trp Ala Asp Gly Tyr Lys Gln Ala Ile Pro
165 170 175
Lys Leu Arg Asn Ala Gly Ile Lys Asn Thr Leu Ile Val Asp Ala Ala
180 185 190
Gly Trp Gly Gln Tyr Pro Gln Ser Ile Val Asp Glu Gly Ala Ala Val
195 200 205
Phe Ala Ser Asp Gln Leu Lys Asn Thr Val Phe Ser Ile His Met Tyr
210 215 220
Glu Tyr Ala Gly Lys Asp Ala Ala Thr Val Lys Thr Asn Met Asp Asp
225 230 235 240
Val Leu Asn Lys Gly Leu Pro Leu Ile Ile Gly Glu Phe Gly Gly Tyr
245 250 255
His Gln Gly Ala Asp Val Asp Glu Ile Ala Ile Met Lys Tyr Gly Gln
260 265 270
Gln Lys Glu Val Gly Trp Leu Ala Trp Ser Trp Tyr Gly Asn Ser Pro
275 280 285
Glu Leu Asn Asp Leu Asp Leu Ala Ala Gly Pro Ser Gly Asn Leu Thr
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Gly Trp Gly Asn Thr Val Val His Gly Thr Asp Gly Ile Gln Gln Thr
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Ser Lys Lys Ala Gly Ile Tyr
325
Claims (16)
1.一种酶组合物,包含至少一种甘露聚糖酶,所述甘露聚糖酶具有的氨基酸序列与SEQID NO:16(Man7)具有至少70%的序列同一性,与SEQ ID NO:12(Man6)具有至少93%的序列同一性,和/或与SEQ ID NO:20(Man14)具有至少79%的序列同一性。
2.如权利要求1所述的酶组合物,还包含:
a、至少一种防腐剂,选自苯甲酸、苯甲酸钠、羟基苯甲酸酯、柠檬酸、抗坏血酸或其组合;
b、选择性地,至少一种多元醇,选自丙二醇、甘油、糖、糖醇、乳酸、硼酸、硼酸衍生物、芳香硼酸酯、苯基硼酸衍生物、肽或其组合;
c、选择性地,至少一种酶,选自有或没有介质的蛋白酶、淀粉酶、纤维素酶、脂肪酶、木聚糖酶、甘露聚糖酶、角质酶、酯酶、植酸酶、DNA酶、果胶酶、果胶水解酶、果胶裂解酶、糖苷酶、阿拉伯糖酶、半乳糖酶、黄原胶酶、木葡聚糖酶、漆酶、过氧化物酶和氧化酶或其组合;以及
d、选择性地,至少一种填充剂,选自麦芽糊精、面粉、氯化钠、硫酸盐、硫酸钠或其组合。
3.如权利要求1-2所述的酶组合物,其为液体组合物或固体组合物的形式,如溶液、分散剂、糊剂、粉末、细粒、颗粒、包衣颗粒、片剂、糕剂、晶体、晶体浆液、凝胶或丸粒。
4.一种重组宿主细胞,包含允许生成至少一种重组多肽的遗传元件,所述重组多肽具有甘露聚糖酶活性且与SEQ ID NO:16的氨基酸序列具有至少70%的序列同一性,与SEQ IDNO:12的氨基酸序列具有至少93%的序列同一性,和/或与SEQ ID NO:20的氨基酸序列具有至少79%的序列同一性,
其中所述宿主细胞选自下组:
真菌细胞,
丝状真菌细胞,其选自子囊菌门、盘菌亚门;优选地选自粪壳菌纲、肉座菌亚纲、肉座菌目、小囊菌目的成员、以及曲霉、金孢霉、毁丝霉和腐质霉;
更优选地选自:肉座菌科、丛赤壳科、麦角菌科、小囊菌科、木霉属(肉座菌属的无性型)、镰刀菌属、赤霉属、丛赤壳属、穗霉属、麦角菌属、绿僵菌属、稻曲菌(Villosiclava)属、蛇形虫草属、头孢菌属和丝孢菌属;
更优选地选自:里氏木霉(红褐肉座菌)、桔绿木霉、长枝木霉、绿木霉、哈茨木霉、棘孢木霉、深绿木霉、拟里氏木霉(Trichoderma parareesei)、尖孢镰刀菌、禾谷镰刀菌、小麦冠腐病菌、镰孢霉、藤仓赤霉、串珠状赤霉、玉蜀黍赤霉、红球丛赤壳菌(血赤壳菌)、黑葡萄穗霉、穗霉(Stachybotrys chlorohalonata)、紫色麦角菌、蝗绿僵菌、金龟子绿僵菌、稻曲病菌、冬虫夏草菌、顶头孢霉(产黄头孢霉)、尖端赛多孢子菌、黑曲霉、泡盛曲霉、米曲霉、金孢子菌(Chrysosporium lucknowense)、嗜热毁丝霉、腐质霉和灰腐质霉;
细菌细胞,优选为革兰氏阳性杆菌如枯草芽孢杆菌、地衣芽孢杆菌、巨大芽孢杆菌、解淀粉芽孢杆菌、短小芽孢杆菌,革兰氏阴性细菌比如大肠杆菌,放线菌比如链霉菌;以及
酵母,如酿酒酵母、毕赤酵母、解脂耶罗维亚酵母;
最优选为里氏木霉或芽孢杆菌。
5.如权利要求4所述的重组宿主细胞,其中所述重组多肽是融合蛋白,其除了包含具有甘露聚糖酶活性的氨基酸序列外,还包含下列中的至少一种:
提供分泌信号序列的氨基酸序列,如解淀粉芽孢杆菌木聚糖酶信号肽;
促进纯化的氨基酸序列,如亲和标签、组氨酸标签;
促进制备的氨基酸序列,如作为载体的氨基酸序列,比如CBM;
具有酶活性的氨基酸序列;以及
为具有结合亲和力的融合蛋白提供的氨基酸序列,如碳水化合物结合部分。
6.一种重组多肽,具有甘露聚糖酶活性,且能够通过使用如权利要求4-5所述的宿主细胞获得。
7.一种制备甘露聚糖酶的方法,包括:
a、培养如权利要求4-5所述的重组宿主细胞,其中
i、所述遗传元件包含至少一个控制序列,该控制序列控制在允许生成所述多肽的条件下在所述重组宿主细胞中生成所述重组多肽;
ii、所述遗传元件选择性地包含至少一个对用于将所述多肽转运到所述宿主细胞外的信号序列进行编码的序列;和
iii、在允许生成所述多肽的条件下进行培养;以及
b、回收所述多肽。
8.一种降解或改性含甘露聚糖的材料的方法,包括:用有效量的如权利要求1-3所述的酶组合物或如权利要求6所述的重组多肽处理所述含甘露聚糖的材料。
9.如权利要求8所述的方法,其中所述含甘露聚糖的材料是植物材料、纺织品、废水、污水、油或其组合。
10.一种动物饲料,包含:
如权利要求1-3所述的酶组合物或能够从如权利要求4-5所述的重组宿主细胞获得的酶;以及
至少一种源于植物的蛋白质源或者含甘露聚糖的制品或副产品;以及
a、选择性地,至少一种酶,选自蛋白酶、淀粉酶、植酸酶、木聚糖酶、内切葡聚糖酶、β-葡聚糖酶或其组合;和
b、选择性地,至少一种填充剂,选自麦芽糊精、面粉、盐、氯化钠、硫酸盐、硫酸钠或其组合。
11.一种饲料添加剂,包括:
如权利要求1-3所述的酶组合物或能够从如权利要求4-5所述的宿主细胞得到的酶;以及
a、选择性地,至少一种酶,选自蛋白酶、淀粉酶、植酸酶、木聚糖酶、内切葡聚糖酶、β-葡聚糖酶或其组合;和
b、选择性地,至少一种填料,选自麦芽糊精、面粉、盐、氯化钠、硫酸盐、硫酸钠或其组合。
12.如权利要求10所述的动物饲料或如权利要求11所述的饲料添加剂在以下应用中的用途:
a、饲喂动物,优选为单胃动物或反刍动物;和/或
b、促进动物增加体重。
13.如权利要求1-3所述的酶组合物或能够从如权利要求4-5的重组宿主细胞获得的酶在洗涤剂中的用途。
14.如权利要求13所述的用途,其中所述洗涤剂是液体洗涤剂或干燥洗涤剂,优选为粉末、条、片剂、小袋、糊剂、凝胶、液体、细粒或颗粒的形式。
15.如权利要求1-3所述的酶组合物或能够从如权利要求4-5所述的重组宿主细胞获得的酶在石油钻探中的用途。
16.如权利要求1-3所述的酶组合物或能够从如权利要求4-5所述的重组宿主细胞获得的酶在咖啡提取物、果汁、菠萝汁或豆奶加工中的用途。
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PCT/FI2018/050229 WO2018185367A1 (en) | 2017-04-05 | 2018-03-27 | Bacterial mannanases |
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EP3385361B1 (en) | 2017-04-05 | 2019-03-27 | Henkel AG & Co. KGaA | Detergent compositions comprising bacterial mannanases |
EP3760714A1 (en) * | 2019-07-02 | 2021-01-06 | AB Enzymes Oy | Improved mannanase variants |
CN115066496A (zh) * | 2020-02-14 | 2022-09-16 | 巴斯夫欧洲公司 | 甘露聚糖酶变体 |
US20230095147A1 (en) * | 2020-02-14 | 2023-03-30 | Basf Se | Mannanase variants |
CN115066495A (zh) * | 2020-02-14 | 2022-09-16 | 巴斯夫欧洲公司 | 甘露聚糖酶变体 |
EP3926039A1 (en) | 2020-06-17 | 2021-12-22 | AB Enzymes GmbH | Use of a nuclease for reducing the viscosity and/or preventing an increase in viscosity of a fermentation broth |
WO2024012894A1 (en) | 2022-07-15 | 2024-01-18 | Basf Se | Alkanolamine formates for enzyme stabilization in liquid formulations |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064619A2 (en) * | 1998-06-10 | 1999-12-16 | Novozymes A/S | Novel mannanases |
KR20020046227A (ko) * | 2000-12-12 | 2002-06-20 | 나가니시 고고 | 피복형 서방성 농약 입제 |
CN105754970A (zh) * | 2014-12-19 | 2016-07-13 | 中国科学院微生物研究所 | 一种碱性β-甘露聚糖酶及其编码基因和它们的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10676751B2 (en) * | 2008-02-29 | 2020-06-09 | The Trustees Of The University Of Pennsylvania | Production and use of plant degrading materials |
CA2892054A1 (en) * | 2012-12-07 | 2014-06-12 | Ling Hua | Compositions and methods of use |
-
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064619A2 (en) * | 1998-06-10 | 1999-12-16 | Novozymes A/S | Novel mannanases |
CN101024826A (zh) * | 1998-06-10 | 2007-08-29 | 诺沃奇梅兹有限公司 | 新的甘露聚糖酶 |
KR20020046227A (ko) * | 2000-12-12 | 2002-06-20 | 나가니시 고고 | 피복형 서방성 농약 입제 |
CN105754970A (zh) * | 2014-12-19 | 2016-07-13 | 中国科学院微生物研究所 | 一种碱性β-甘露聚糖酶及其编码基因和它们的应用 |
Non-Patent Citations (2)
Title |
---|
佚名: "Q5WL93,Mannan endo-1,4-beta-mannosidase", 《UNIPROT》, 23 November 2004 (2004-11-23), pages 1 - 4 * |
蒋建新等编著: "纺织品清洁染整加工技术", 北京:中国纺织出版社 , pages: 225 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116240007A (zh) * | 2021-12-08 | 2023-06-09 | 天津大港油田滨港集团博弘石油化工有限公司 | 一种生物酶降粘驱油剂的制备方法 |
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