CN110548214A - 微型智能海藻酸钙水凝胶末端操作器的制备方法 - Google Patents
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Abstract
本发明提供了一种基于不同微电极的微型智能海藻酸钙水凝胶末端操作器的制备方法。该方法包括电沉积步骤,令沉积溶液在非均匀磁场作用下沉积与阳极表面;处理步骤,将所得水凝胶微结构转移到氯化钙溶液中,令水凝胶微结构充分自卷;拾取步骤,将自卷的藻酸盐单层膜微结构收集在培养皿中,置于特定环境下保存。本发明能够提供一种可降解的、方便的微操作器,它可以被局部地制成不同的功能部件。
Description
技术领域
本发明属于药物微载体技术领域,具体涉及一种基于不同微电极的微型智能海藻酸钙水凝胶末端操作器的制备方法。
背景技术
药物输送是指将药物以某种特定的途径输送至病灶部位,从而达到治疗疾病的目的。常见的临床药物输送方式有肠内给药方式,肠外给药和局部给药等。口服给药和直肠给药是两种肠内给药方式,药物被肠胃粘膜、肝脏或直肠粘膜等吸收后进入血液,经过血液循环运送至全身,从而达到治疗疾病的目的。静脉注射、肌内注射和皮下注射是三种常见的肠外给药方式,是指将药物直接注射至静脉、肌肉组织和皮下组织。局部给药方式包括通过眼、肺、腹腔和皮肤等进行药物输送、直接将药物输送至病灶部位从而达到治疗疾病的目的,局部用药相比全身用药可以获得更高的药物浓度,副作用更小,具有显著的优越性。传统的药物输送虽然可以对某些特定疾病的诊疗起到一定的效果,但是大都面临药物释放速度快、药物作用时间短、需要长期、多次给药等问题。为了解决这些问题,近些年来,随着医药、化学、材料、工程、信息、生命等科学的快速发展,药物微载体制备技术已受到国内外研究人员越来越多的关注,药物与微载体相结合形成微载体药物递送系统,其拥有靶向控释、安全可靠及可修饰等特性,按照临床需要选取适当种类的药物微载体,不但能够将药物定点运送至靶器官,而且可以有效地调节药物的物理化学特性,从而达到提高治疗效果、减小毒副作用和降低治疗成本等效果。目前,药物微载体的研究主要集中于微球、微囊、纳米粒、脂质体、微乳、微泡以及包合物等方面。
然而,已有的药物载体制备技术有着装置复杂、制备困难、不可降解等技术屏障。因此,在精确的医学和组织工程领域,我们需要一种可降解的、方便的微操作器,它可以被局部地制成不同的功能部件。
发明内容
本发明的目的是:提出一种基于不同微电极的微型智能海藻酸钙水凝胶末端操作器的制备方法。
本发明的技术方案如下:
本发明提出了一种基于不同微电极加工出不同结构的微操作器,以实现不同功能的微型智能海藻酸钙水凝胶末端操作器的制备方法,包括:电沉积、处理、拾取。该方法的特征在于:
优选地,所述电沉积进一步包括:
S1:通过旋涂机在FTO玻璃上涂覆光刻胶,并通过光刻技术形成不同微电极;
S2:将沉积溶液填充到两个电极之间,由两个高度为1mm厚的绝缘垫片维持;
S3:向电极施加直流电压,维持时间为1-5秒;
S4:将阳极在HEPES缓冲液中洗涤5分钟,直到所有的水凝胶微结构从ITO 玻璃上分离。
优选地,所述处理进一步包括:
S1:将所述水凝胶微结构转移到氯化钙溶液中,持续2分钟,令水凝胶微结构充分自卷;
优选地,所述拾取进一步包括:
S1:将所述微结构收集在培养皿中;
S2:将培养皿置于特定环境中保存。
优选地,所述沉积溶液包括CaCO3、药物、细胞、磁性纳米粒子及监测装备。
通过以上技术方案,本发明通过所述电沉积模块产生特定的水凝胶,然后将所述水凝胶经过所述处理形成自卷的藻酸盐单层膜微结构。该微结构能够通过磁场定位,并在柠檬酸钠溶液中降解。本发明能够提供一种可降解的、方便的微载体,它可以被局部地制成不同的功能部件。
图1为本发明的基于电沉积的微组织构建装置示意图;图1(a)为条带状水凝胶电沉积示意图,图1(b)为放射状水凝胶电沉积示意图。
图2为海藻酸盐单层膜微结构示意图,图2(a)和图2(b)分别为电沉积后条带状和放射状水凝胶微结构。
图3为海藻酸盐单层膜微结构自卷变形示意图;图3(a)和图3(b)分别为条带状水凝胶微结构自卷曲后形状示意图,图3(c)为放射状水凝胶微结构自卷曲后形状示意图。
具体实施方式
下面给出的实施例对本发明作进一步阐述,但实施例不对本发明构成任何限制。
本发明提供了一种可降解自卷的微型智能海藻酸钙水凝胶末端操作器的制备方法,包括电沉积、处理、拾取。
优选地,所述电沉积进一步包括:
在一优选的实施方式中,所述S11进一步包括:
S1:通过旋涂机在50mm×50mm尺寸的FTO玻璃上涂覆10μm左右厚的光刻胶,在FTO玻璃上形成特定形状的凹陷图案,作为阳极;
S2:将2ml沉积溶液填充到两个3.5-4V的电极之间,由两个高度为1mm厚的绝缘垫片维持;
S3:向电极施加直流电压,维持时间为1-5秒;
S4:将阳极在HEPES缓冲液中洗涤5分钟,直到所有的水凝胶微结构从FTO 玻璃上分离。
在一优选的实施方式中,所述处理进一步包括:
S1:将所述水凝胶微结构转移到0.5%的氯化钙溶液中,持续2分钟,令水凝胶微结构充分自卷,该水凝胶微结构可在柠檬酸钠溶液中自行还原形状并溶解;
在一优选的实施方式中,所述拾取进一步包括:
S1:将所述微结构收集在培养皿中;
S2:将培养皿置于特定环境中保存。
在一优选的实施方式中,所述所需成分包括CaCO3、药物、细胞、磁性纳米粒子及监测装备等。
以上所述仅为本发明的一种具体实施例,以上实施例仅用于对本发明的技术方案和发明构思做说明而非限制本发明的权利要求范围。凡本技术领域中技术人员在本专利的发明构思基础上结合现有技术,通过逻辑分析、推理或有限实验可以得到的其他技术方案,也应该被认为落在本发明的权利要求保护范围之内。
Claims (5)
1.一种可降解自卷微型智能海藻酸钙水凝胶末端操作器的制备方法,包括:电沉积、处理、拾取。
2.根据权利要求1所述的可降解自卷微型智能海藻酸钙水凝胶末端操作器的制备方法,其特征在于,所述电沉积步骤进一步包括:
S1:通过旋涂机在FTO玻璃上涂覆光刻胶,在FTO玻璃上形成特定形状的凹陷图案,作为阳极;
S2:将沉积溶液填充到两个电极之间,由两个高度为1mm厚的绝缘垫片维持;
S3:向电极施加直流电压,维持时间为1-5秒;
S4:将阳极在HEPES缓冲液中洗涤5分钟,直到所有的水凝胶微结构从FTO玻璃上分离。
3.根据权利要求1所述的可降解自卷微型智能海藻酸钙水凝胶末端操作器的制备方法,其特征在于,所述处理步骤进一步包括:
S1:将所述水凝胶微结构转移到氯化钙溶液中,持续2分钟,令水凝胶微结构充分自卷。
4.根据权利要求1所述的可降解自卷微型智能海藻酸钙水凝胶末端操作器的制备方法,其特征在于,所述拾取步骤进一步包括:
S1:将所述微结构收集在培养皿中;
S2:将培养皿置于特定环境中保存。
5.根据权利要求1-4中任一项所述的可降解自卷微型智能海藻酸钙水凝胶末端操作器的制备方法,其特征在于,所述沉积溶液成分包括CaCO3、药物、细胞、磁性纳米粒子及监测装备等。
通过以上技术方案,本发明通过所述电沉积模块产生特定的水凝胶,然后将所述水凝胶经过所述处理形成自卷的藻酸盐单层膜微结构。该微结构能够通过磁场定位,并在柠檬酸钠溶液中降解。本发明能够提供一种可降解的、方便的微载体,它可以被局部地制成不同的功能部件。
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