CN110538089B - 一种抑菌祛口臭的宠物牙膏 - Google Patents

一种抑菌祛口臭的宠物牙膏 Download PDF

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CN110538089B
CN110538089B CN201910841241.1A CN201910841241A CN110538089B CN 110538089 B CN110538089 B CN 110538089B CN 201910841241 A CN201910841241 A CN 201910841241A CN 110538089 B CN110538089 B CN 110538089B
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童星
徐志良
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Abstract

本发明涉及一种抑菌祛口臭的宠物牙膏,由保湿剂、抗菌剂、驱虫剂、增稠剂、维生素B族、香精、防腐剂、水按一定的重量比配制而成,该抑菌祛口臭的宠物牙膏以甲硫腺苷作为抗菌成分,香茅酸作为驱虫成分。本发明的抑菌祛口臭的宠物牙膏对宠物口腔常见致病菌、体内寄生虫有良好的抑制作用,能从源头上控制臭味物质产生,长期使用不产生抗性和耐药性;不含摩擦剂、发泡剂、山梨醇和木糖醇保湿剂,吞咽后不会引起结石和肠道不适;含有宠物易缺乏的维生素B族,可以改善宠物的消化、口腔溃疡、皮肤炎症等问题,清洁口腔的同时,为宠物补充营养物质。

Description

一种抑菌祛口臭的宠物牙膏
技术领域
本发明属于口腔清洁护理用品技术领域,具体涉及一种抑菌祛口臭的宠物牙膏。
背景技术
动物的牙齿跟人类的十分相似,从组织结构到颚骨结构都是一样,由于动物不能经常做口腔清洁,长期的食物残渣附着于牙齿表面积累形成牙垢,加上细菌不断繁殖,导致牙龈发炎,引起牙龈红肿、疼痛。随着年岁的增加,牙石会增厚,损伤牙龈和牙根,甚至使牙齿过早脱落或引起动物口腔变形。饮食营养不均衡,缺乏B族维生素时会引起口腔溃疡或糜烂,严重及免疫缺陷时伴有口臭、流涎、咀嚼障碍,饮食量下降、甚至拒食,严重影响胃肠功能。
另外,宠物口臭与口腔健康、饮食习惯、胃肠道健康有关,例如患有口腔疾病如牙周病、牙结石时,唾液会更粘稠,不仅带来强烈异味,还会产生大量有害菌,这些有害菌在口腔温暖、潮湿的环境中大量繁殖,会产生硫磺成分,形成臭味;当宠物胃肠道菌群失调、粮食代谢异常时,会发酵产生异常的氨味,同时进食腐败食物、高蛋白质、含硫量高的氨基酸食物,会产生带有臭味的胃气。
刷牙、漱口或者咀嚼洁牙骨可以帮助宠物清除牙垢和口腔异味,但一般宠物不喜欢刷牙,而且犬猫不会像人一样能将泡沫吐出来,所以要求宠物牙膏对宠物无危害,吞咽后不会引起不适。
目前市场上的宠物牙膏存在以下问题:一、现有的添加化学抗菌剂的宠物牙膏虽然抑菌效果明显,但长期使用存在安全性问题,易产生抗性和耐药性;二、市场上的宠物牙膏多数沿用人牙膏配方,由水、摩擦剂、保湿剂、发泡剂、增稠剂、防腐剂、香味剂、功能性成分等构成,但宠物身体状况、饮食结构、卫生状况与人存在差异,不能直接使用人牙膏,例如碳酸钙、磷酸钙类摩擦剂,吞咽后容易形成结石,对宠物身体有害,常用的木糖醇、山梨糖醇类保湿剂易引起宠物肠道不适,其中木糖醇会引发胰岛素大量释放,随之血糖降低,宠物就会变得虚弱、嗜睡,甚至出现昏迷、急性肝坏死等情况。另外驱虫剂一般用于香皂、洗涤剂、膏霜等产品中达到驱虫的效果,但目前市场上还鲜见采用驱虫物质在口腔疗效保健方面达到显效的宠物保健牙膏。
甲硫腺苷是腺苷的衍生物,天然存在于哺乳动物的各类组织中,参与多种生化活动,对口腔致病菌有广谱的抑制作用,如变异链球菌、黏放线菌、内氏放线菌、牙龈二氧化碳嗜纤维菌、具核梭杆菌的最小抑菌浓度分别为63μg/mL、63μg/mL、32μg/mL、125μg/mL、500μg/mL,目前还未应用于口腔护理产品中。
香茅酸有抗菌性和驱虫性,对金黄色葡萄球菌、枯草杆菌、大肠杆菌的最小抑菌浓度为500×10-6,对绿脓杆菌和黑色弗状菌的最小抑菌浓度为1000×10-6,2%香茅酸对蚊子的驱除率(0.5h内测定)达到100%,0.1%香茅酸对屋尘螨的杀死率达到92%,早就应用于如软饮料冰制食品、胶冻布丁、糖果烘烤食品等食品中,也可作为驱虫剂、抗菌剂用于香皂、洗涤剂、膏霜等产品中,目前还未应用于口腔护理产品中。
专利号为CN 107441019 A的中国专利公开了一种宠物用牙膏及其制备方法,该发明宠物牙膏含有摩擦剂、发泡剂、保湿剂、香味剂、功效成分(中药和酵素)等,专利号为CN107049810 A的中国专利公开了一种宠物可食用牙膏及生产方法,该发明宠物牙膏由烷基糖苷、碳酸钙、山梨酸钾、宠物清洁诱食料、益生元添加剂等成分组成。上述两个专利的配方中都含有摩擦剂和发泡剂,宠物吞咽后容易形成结石,对身体有害;同时上述两个专利的保湿剂均含有山梨糖醇,易引起宠物肠道不适。
专利号为CN 10888558 A的中国专利公开了一种宠物洁牙凝胶及其制备方法,该发明宠物洁齿凝胶由绿茶提取物、芦荟提取物、西砒氯铵、保湿剂、增稠剂、防腐剂等组成,其中的化学抗菌剂易产生抗性和耐药性。
发明内容
本发明的目的是提供一种抑菌祛口臭的宠物牙膏,对宠物口腔常见致病菌、体内寄生虫有良好的抑制作用,能从源头上控制臭味物质产生,不产生抗性和耐药性,吞咽后不会引起结石和肠道不适,可以改善宠物的消化、口腔溃疡、皮肤炎症等问题,清洁口腔的同时,为宠物补充营养物质,温和安全。
本发明解决上述问题所采用的技术方案为:一种抑菌祛口臭的宠物牙膏配方,所述抑菌祛口臭的宠物牙膏由以下重量百分比的组分组成:
保湿剂 10-20%
天然抗菌剂 0.02-0.5%
驱虫剂 0.1-0.5%
增稠剂 0.5-2%
维生素B族 0.5-2%
香精 0.2-1%
防腐剂 0.1-0.5%
水 余量,
各组分的重量百分比之和为100%。
优选地,所述保湿剂为赤藓醇。
优选地,所述天然抗菌剂为甲硫腺苷。
优选地,所述驱虫剂为香茅酸。
优选地,所述增稠剂为纤维素类增稠剂。
优选地,所述维生素B族为维生素B1、维生素B2、维生素B3
与现有技术相比,本发明的优点在于:
(1)结合宠物的口腔环境及生理特性,优选天然抗菌、驱虫物质,对宠物口腔常见变异链球菌、黏放线菌、内氏放线菌、牙龈二氧化碳嗜纤维菌、具核梭杆菌等致病菌、螨虫等寄生虫有良好的抑制作用,配合牙刷的物理摩擦作用,减少口腔食物残渣和牙垢,从源头上控制臭味物质产生,长期使用不产生抗性和耐药性。
(2)不含摩擦剂、发泡剂,优选纤维素类增稠剂和赤藓醇作为保湿剂,不会引起宠物肠道不适,吞咽对宠物无副作用。
(3)维生素B族可以改善宠物的消化、口腔溃疡、皮肤炎症等问题,清洁口腔的同时,为宠物补充营养物质。
具体实施方式
以下结合实施例对本发明作进一步详细描述。
实施例1
实施例1中抑菌祛口臭的宠物牙膏由以下重量百分比的组分组成:
赤藓醇 10%
甲硫腺苷 0.05%
香茅酸 0.1%
羧甲基纤维素钠 1%
维生素B1 0.2%
维生素B2 0.2%
维生素B3 0.2%
鸡肉味香精 0.3%
苯甲酸钠 0.1%
水 余量,
各组分的重量百分比之和为100%。
实施例2
实施例2中抑菌祛口臭的宠物牙膏由以下重量百分比的组分组成:
赤藓醇 12%
甲硫腺苷 0.1%
香茅酸 0.15%
羟乙基纤维素 1%
维生素B1 0.25%
维生素B2 0.25%
维生素B3 0.25%
牛肉味香精 0.3%
苯甲酸钠 0.1%
水 余量,
各组分的重量百分比之和为100%。
实施例3
实施例3中抑菌祛口臭的宠物牙膏由以下重量百分比的组分组成:
赤藓醇 15%
甲硫腺苷 0.1%
香茅酸 0.2%
羧甲基纤维素钠 0.6%
羟乙基纤维素 0.4%
维生素B1 0.3%
维生素B2 0.3%
维生素B3 0.3%
鱼肉味香精 0.3%
苯甲酸钠 0.1%
水 余量,
各组分的重量百分比之和为100%。
对比例1,与实施例3的区别仅在于:不含甲硫腺苷。
对比例2,与实施例3的区别仅在于:不含香茅酸。
1、采用本发明所制备的抑菌祛口臭的宠物牙膏抑菌效果评价:
选取变异链球菌、黏放线菌、牙龈二氧化碳嗜纤维菌、具核梭杆菌、金黄色葡萄球菌、大肠杆菌作为试验菌株,观察实施例和对比例配制的牙膏对这些细菌是否起作用。
Figure DEST_PATH_IMAGE001
上述结果说明,添加甲硫腺苷的宠物牙膏对口腔有害菌变异链球菌、黏放线菌、牙龈二氧化碳嗜纤维菌、具核梭杆菌有抑制生长作用,当甲硫腺苷浓度达到0.1%时抑菌率>90%,具有较强的抑菌效果。添加香茅酸的宠物牙膏对肠道致病菌金黄色葡萄球菌、大肠杆菌有抑制生长作用,当香茅酸浓度达到0.1%时抑菌率>90%,具有较强的抑菌效果。
2、采用本发明所制备的抑菌祛口臭的宠物牙膏除螨效果评价:
参照NY/T 1151.2-2006《农药登记卫生用杀虫剂室内药效试验方法及评价 第二部分:灭螨和驱螨剂》,观察实施例和对比例配制牙膏的除螨效果,供试昆虫为尘螨,试验条件为25±2℃培养箱,相对湿度75±5%。
Figure DEST_PATH_IMAGE003
上述结果说明,添加香茅酸的宠物牙膏对口腔螨虫具有良好的杀灭效果,当香茅酸浓度达到0.15%时灭螨率可达到100%。
除上述实施例外,本发明还包括有其他实施方式,凡采用等同变换或者等效替换方式形成的技术方案,均应落入本发明权利要求的保护范围之内。

Claims (3)

1.一种抑菌祛口臭的宠物牙膏,其特征在于:所述抑菌祛口臭的宠物牙膏由以下重量百分比的组分组成:
保湿剂 10-20%
天然抗菌剂 0.02-0.5%
驱虫剂 0.1-0.5%
增稠剂 0.5-2%
维生素B族 0.5-2%
香精 0.2-1%
防腐剂 0.1-5%
水 余量,
各组分的重量百分比之和为100%;
所述天然抗菌剂为甲硫腺苷;
所述驱虫剂为香茅酸;
所述增稠剂为纤维素类增稠剂。
2.根据权利要求1所述的抑菌祛口臭的宠物牙膏,其特征在于:所述保湿剂为赤藓醇。
3.根据权利要求1所述的抑菌祛口臭的宠物牙膏,其特征在于:所述维生素B族为维生素B1、维生素B2和维生素B3
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US4948783A (en) * 1985-01-24 1990-08-14 Kabushiki Kaisya Advance Kaihatsu Kenkyujo Anticariogenic or antiperidontitic method
JPH111404A (ja) * 1997-06-11 1999-01-06 Dainippon Jochugiku Co Ltd 新規害虫忌避剤

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US4948783A (en) * 1985-01-24 1990-08-14 Kabushiki Kaisya Advance Kaihatsu Kenkyujo Anticariogenic or antiperidontitic method
JPH111404A (ja) * 1997-06-11 1999-01-06 Dainippon Jochugiku Co Ltd 新規害虫忌避剤

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