CN110520444A - 用于制备多特异性抗体的多肽接头 - Google Patents
用于制备多特异性抗体的多肽接头 Download PDFInfo
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- CN110520444A CN110520444A CN201880009175.5A CN201880009175A CN110520444A CN 110520444 A CN110520444 A CN 110520444A CN 201880009175 A CN201880009175 A CN 201880009175A CN 110520444 A CN110520444 A CN 110520444A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
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| EP17305022 | 2017-01-09 | ||
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| PCT/EP2018/050481 WO2018127608A1 (en) | 2017-01-09 | 2018-01-09 | A polypeptide linker for preparing multispecific antibodies |
Publications (1)
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| CN110520444A true CN110520444A (zh) | 2019-11-29 |
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|---|---|
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| EP (1) | EP3565847A1 (de) |
| JP (2) | JP2020503873A (de) |
| KR (1) | KR102589422B1 (de) |
| CN (1) | CN110520444A (de) |
| AU (1) | AU2018206229B2 (de) |
| BR (1) | BR112019014147A2 (de) |
| CA (1) | CA3052084A1 (de) |
| IL (1) | IL267886B1 (de) |
| MX (1) | MX2019008241A (de) |
| SG (1) | SG11201906313SA (de) |
| WO (1) | WO2018127608A1 (de) |
| ZA (1) | ZA201905160B (de) |
Cited By (1)
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| CN115724986A (zh) * | 2022-07-11 | 2023-03-03 | 惠和生物技术(上海)有限公司 | 三特异性抗体及其用途 |
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| CN109476741B (zh) | 2016-03-25 | 2023-02-24 | 拜奥穆尼克斯制药 | 与cd38和pd-l1结合的分子 |
| US12054550B2 (en) | 2016-04-28 | 2024-08-06 | Biomunex Pharmaceuticals | Bispecific antibodies targeting EGFR and HER2 |
| SG11201906313SA (en) * | 2017-01-09 | 2019-08-27 | Biomunex Pharmaceuticals | A polypeptide linker for preparing multispecific antibodies |
| CN111094355A (zh) | 2017-03-27 | 2020-05-01 | 拜奥穆尼克斯制药 | 稳定的多特异性抗体 |
| WO2020136566A1 (en) | 2018-12-24 | 2020-07-02 | Sanofi | Multispecific binding proteins with mutant fab domains |
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| WO2013005194A2 (en) * | 2011-07-07 | 2013-01-10 | Centre National De La Recherche Scientifique | Multispecific antibodies |
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| KR20020093029A (ko) * | 2000-04-11 | 2002-12-12 | 제넨테크, 인크. | 다가 항체 및 그의 용도 |
| RU2349340C2 (ru) * | 2002-10-10 | 2009-03-20 | Мерк Патент Гмбх | Биспецифические антитела к erb-b и их применение для лечения опухолей |
| US7910101B2 (en) * | 2004-10-25 | 2011-03-22 | Centocor, Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
| WO2009097325A1 (en) * | 2008-01-28 | 2009-08-06 | Medimmune Limited | Stabilized angiopoietin-2 antibodies and uses thereof |
| US9409950B2 (en) | 2010-12-23 | 2016-08-09 | Biogen Ma Inc. | Linker peptides and polypeptides comprising same |
| DK2771022T3 (da) * | 2011-10-11 | 2020-09-28 | Viela Bio Inc | Cd40l-specifikke tn3-afledte skeletter (scaffolds) og fremgangsmåder til anvendelse deraf |
| BR112015009070A2 (pt) * | 2012-10-23 | 2017-07-04 | Statens Seruminstitut | proteína de fusão ou coquetel de antígenos; uso de uma proteína de fusão ou um coquetel de antígenos; vacina; e método para imunizar um animal, que inclui um ser humano, contra tuberculose causada por microbactérias virulentas |
| DE102014213460B4 (de) * | 2014-07-10 | 2022-10-20 | Bayerische Motoren Werke Aktiengesellschaft | Klappenanordnung für ein Kraftfahrzeug |
| GB201500319D0 (en) * | 2015-01-09 | 2015-02-25 | Agency Science Tech & Res | Anti-PD-L1 antibodies |
| PL3313441T3 (pl) * | 2015-06-24 | 2024-08-19 | Janssen Biotech, Inc. | Immunomodulacja i leczenie guzów litych przeciwciałami swoiście wiążącymi cd38 |
| CN109476741B (zh) | 2016-03-25 | 2023-02-24 | 拜奥穆尼克斯制药 | 与cd38和pd-l1结合的分子 |
| US12054550B2 (en) | 2016-04-28 | 2024-08-06 | Biomunex Pharmaceuticals | Bispecific antibodies targeting EGFR and HER2 |
| SG11201906313SA (en) * | 2017-01-09 | 2019-08-27 | Biomunex Pharmaceuticals | A polypeptide linker for preparing multispecific antibodies |
| CN111094355A (zh) | 2017-03-27 | 2020-05-01 | 拜奥穆尼克斯制药 | 稳定的多特异性抗体 |
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Patent Citations (1)
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| WO2013005194A2 (en) * | 2011-07-07 | 2013-01-10 | Centre National De La Recherche Scientifique | Multispecific antibodies |
Non-Patent Citations (1)
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| JOSÉE GOLAY ET AL.,: ""Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies"", 《THE JOURNAL OF IMMUNOLOGY》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115724986A (zh) * | 2022-07-11 | 2023-03-03 | 惠和生物技术(上海)有限公司 | 三特异性抗体及其用途 |
| WO2024012457A1 (zh) * | 2022-07-11 | 2024-01-18 | 惠和生物技术(上海)有限公司 | 三特异性抗体及其用途 |
| CN115724986B (zh) * | 2022-07-11 | 2024-07-19 | 惠和生物技术(上海)有限公司 | 三特异性抗体及其用途 |
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| AU2018206229B2 (en) | 2024-09-19 |
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| ZA201905160B (en) | 2021-05-26 |
| AU2018206229A1 (en) | 2019-08-29 |
| BR112019014147A2 (pt) | 2020-02-11 |
| JP2020503873A (ja) | 2020-02-06 |
| RU2019125228A (ru) | 2021-02-09 |
| CA3052084A1 (en) | 2018-07-12 |
| MX2019008241A (es) | 2019-12-09 |
| IL267886B1 (en) | 2024-07-01 |
| US20240209118A1 (en) | 2024-06-27 |
| SG11201906313SA (en) | 2019-08-27 |
| IL267886A (en) | 2019-09-26 |
| KR102589422B1 (ko) | 2023-10-13 |
| US11958913B2 (en) | 2024-04-16 |
| JP2023027215A (ja) | 2023-03-01 |
| US20190330377A1 (en) | 2019-10-31 |
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