CN110507829B - 铁钨复合氧化物纳米晶团簇的制备方法及其应用 - Google Patents
铁钨复合氧化物纳米晶团簇的制备方法及其应用 Download PDFInfo
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- CN110507829B CN110507829B CN201910702198.0A CN201910702198A CN110507829B CN 110507829 B CN110507829 B CN 110507829B CN 201910702198 A CN201910702198 A CN 201910702198A CN 110507829 B CN110507829 B CN 110507829B
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- water
- tungsten
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- iron
- oxide nanoparticles
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- 239000002131 composite material Substances 0.000 title claims abstract description 35
- JHOPGIQVBWUSNH-UHFFFAOYSA-N iron tungsten Chemical compound [Fe].[Fe].[W] JHOPGIQVBWUSNH-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 67
- 239000002105 nanoparticle Substances 0.000 claims abstract description 63
- 239000008367 deionised water Substances 0.000 claims abstract description 62
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 62
- 238000006243 chemical reaction Methods 0.000 claims abstract description 57
- SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims abstract description 28
- QGLKJKCYBOYXKC-UHFFFAOYSA-N nonaoxidotritungsten Chemical compound O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1 QGLKJKCYBOYXKC-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229910001930 tungsten oxide Inorganic materials 0.000 claims abstract description 28
- 229920002873 Polyethylenimine Polymers 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 239000004094 surface-active agent Substances 0.000 claims abstract description 10
- 239000003513 alkali Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 150000003657 tungsten Chemical class 0.000 claims abstract description 8
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 8
- 125000000129 anionic group Chemical group 0.000 claims abstract description 7
- 239000005416 organic matter Substances 0.000 claims abstract description 7
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims abstract description 4
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 4
- 238000000975 co-precipitation Methods 0.000 claims abstract description 3
- 238000001338 self-assembly Methods 0.000 claims abstract description 3
- 238000005979 thermal decomposition reaction Methods 0.000 claims abstract description 3
- 238000003756 stirring Methods 0.000 claims description 32
- 238000005406 washing Methods 0.000 claims description 19
- 239000002159 nanocrystal Substances 0.000 claims description 15
- 238000003384 imaging method Methods 0.000 claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 239000004584 polyacrylic acid Substances 0.000 claims description 7
- 239000001509 sodium citrate Substances 0.000 claims description 7
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 7
- 229910052742 iron Inorganic materials 0.000 claims description 4
- -1 iron ions Chemical class 0.000 claims description 4
- 239000002872 contrast media Substances 0.000 claims description 3
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 2
- 230000002902 bimodal effect Effects 0.000 claims description 2
- 229910001447 ferric ion Inorganic materials 0.000 claims description 2
- 229910001448 ferrous ion Inorganic materials 0.000 claims description 2
- 238000007885 magnetic separation Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 238000013170 computed tomography imaging Methods 0.000 abstract description 5
- 239000000243 solution Substances 0.000 description 95
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 239000006185 dispersion Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 6
- 235000011114 ammonium hydroxide Nutrition 0.000 description 6
- 229940044631 ferric chloride hexahydrate Drugs 0.000 description 6
- 229960002089 ferrous chloride Drugs 0.000 description 6
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical group Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 6
- NQXWGWZJXJUMQB-UHFFFAOYSA-K iron trichloride hexahydrate Chemical group O.O.O.O.O.O.[Cl-].Cl[Fe+]Cl NQXWGWZJXJUMQB-UHFFFAOYSA-K 0.000 description 6
- 238000002595 magnetic resonance imaging Methods 0.000 description 6
- YOUIDGQAIILFBW-UHFFFAOYSA-J tetrachlorotungsten Chemical compound Cl[W](Cl)(Cl)Cl YOUIDGQAIILFBW-UHFFFAOYSA-J 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 239000011259 mixed solution Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000012299 nitrogen atmosphere Substances 0.000 description 5
- 229920005862 polyol Polymers 0.000 description 5
- 150000003077 polyols Chemical class 0.000 description 5
- 238000000527 sonication Methods 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000003917 TEM image Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 238000002059 diagnostic imaging Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 239000002114 nanocomposite Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- SDDGNMXIOGQCCH-UHFFFAOYSA-N 3-fluoro-n,n-dimethylaniline Chemical group CN(C)C1=CC=CC(F)=C1 SDDGNMXIOGQCCH-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012984 biological imaging Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- XAYGUHUYDMLJJV-UHFFFAOYSA-Z decaazanium;dioxido(dioxo)tungsten;hydron;trioxotungsten Chemical compound [H+].[H+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O XAYGUHUYDMLJJV-UHFFFAOYSA-Z 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229960002413 ferric citrate Drugs 0.000 description 1
- 239000011640 ferrous citrate Substances 0.000 description 1
- 235000019850 ferrous citrate Nutrition 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 1
- XNCMOUSLNOHBKY-UHFFFAOYSA-H iron(3+);trisulfate;heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O XNCMOUSLNOHBKY-UHFFFAOYSA-H 0.000 description 1
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 1
- APVZWAOKZPNDNR-UHFFFAOYSA-L iron(ii) citrate Chemical compound [Fe+2].OC(=O)CC(O)(C([O-])=O)CC([O-])=O APVZWAOKZPNDNR-UHFFFAOYSA-L 0.000 description 1
- 238000000707 layer-by-layer assembly Methods 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- VVRQVWSVLMGPRN-UHFFFAOYSA-N oxotungsten Chemical class [W]=O VVRQVWSVLMGPRN-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- XMVONEAAOPAGAO-UHFFFAOYSA-N sodium tungstate Chemical compound [Na+].[Na+].[O-][W]([O-])(=O)=O XMVONEAAOPAGAO-UHFFFAOYSA-N 0.000 description 1
- 238000004729 solvothermal method Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- ITRNXVSDJBHYNJ-UHFFFAOYSA-N tungsten disulfide Chemical compound S=[W]=S ITRNXVSDJBHYNJ-UHFFFAOYSA-N 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 229910006297 γ-Fe2O3 Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1887—Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G41/00—Compounds of tungsten
- C01G41/02—Oxides; Hydroxides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
- C01G49/08—Ferroso-ferric oxide [Fe3O4]
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Iron (AREA)
Abstract
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910702198.0A CN110507829B (zh) | 2019-07-31 | 2019-07-31 | 铁钨复合氧化物纳米晶团簇的制备方法及其应用 |
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| CN201910702198.0A CN110507829B (zh) | 2019-07-31 | 2019-07-31 | 铁钨复合氧化物纳米晶团簇的制备方法及其应用 |
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| CN110507829A CN110507829A (zh) | 2019-11-29 |
| CN110507829B true CN110507829B (zh) | 2021-08-31 |
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| CN114053966A (zh) * | 2021-03-04 | 2022-02-18 | 中国科学院宁波材料技术与工程研究所 | 一种亲水性磁性纳米材料及其制备方法与应用 |
| CN114229898A (zh) * | 2021-12-09 | 2022-03-25 | 沈阳化工大学 | 一种用模板制备多面体三氧化钨方法 |
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| CN103341183B (zh) * | 2013-06-13 | 2015-03-18 | 上海师范大学 | 纳米氧化钨wo2.9在ct造影剂材料中的应用 |
| CN107899023A (zh) * | 2017-12-28 | 2018-04-13 | 山西省肿瘤医院 | 一种纳米造影剂及其制备方法 |
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Application publication date: 20191129 Assignee: Yunnan Benyi Biotechnology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023530000011 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230403 Application publication date: 20191129 Assignee: Kunming Junxiang Pharmaceutical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023530000013 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230403 Application publication date: 20191129 Assignee: Kunming Daren Medical Equipment Co.,Ltd. Assignor: Hubei University Contract record no.: X2023530000012 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230403 |
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Application publication date: 20191129 Assignee: Hubei Yueming Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000151 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230608 Application publication date: 20191129 Assignee: BORUNCHENG (WUHAN) PHARMACEUTICAL CO.,LTD. Assignor: Hubei University Contract record no.: X2023420000155 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230608 Application publication date: 20191129 Assignee: Wuhan Dorman Health Technology Partnership (L.P.) Assignor: Hubei University Contract record no.: X2023420000149 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230607 Application publication date: 20191129 Assignee: Wuhan Zhencai Intelligent Manufacturing Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000150 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230608 Application publication date: 20191129 Assignee: Wuhan Hengtai Bainian Trading Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000157 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230609 Application publication date: 20191129 Assignee: Wuhan Yihui Medical Technology Service Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000158 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230609 Application publication date: 20191129 Assignee: Hubei Wanhai Saikang Life Science Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000154 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230608 Application publication date: 20191129 Assignee: Wuhan golden Jirui Medical Technology Development Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000152 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230608 Application publication date: 20191129 Assignee: Wuhan Zero Action Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000148 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230607 Application publication date: 20191129 Assignee: Wuhan Weier Laibo Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000153 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230608 Application publication date: 20191129 Assignee: Wuhan Ruixin Zetai Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000156 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230608 |
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Application publication date: 20191129 Assignee: Wuhan Kaikang Technology Development Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000164 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230612 Application publication date: 20191129 Assignee: Wuhan Lingyi Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000160 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230612 Application publication date: 20191129 Assignee: Hubei Zeshunzhi Science and Trade Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000174 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230614 Application publication date: 20191129 Assignee: Wuhan Jingdong Medical Technology Partnership (L.P.) Assignor: Hubei University Contract record no.: X2023420000159 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230612 Application publication date: 20191129 Assignee: Wuhan Warmth Medical Services Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000178 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230615 Application publication date: 20191129 Assignee: Wuhan Zhencai Zhizao Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000162 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230612 Application publication date: 20191129 Assignee: Hubei Zheshunkai Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000177 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230615 Application publication date: 20191129 Assignee: Hubei Shengrui Medical Equipment Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000163 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230612 Application publication date: 20191129 Assignee: Wuhan Dorman Health Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000161 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230612 Application publication date: 20191129 Assignee: WUHAN JUNAN YOULIAN MEDICAL TECHNOLOGY Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000165 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230612 |
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Application publication date: 20191129 Assignee: Wuhan Shuidi 1872 Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000180 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230616 Application publication date: 20191129 Assignee: Wuhan Youyimo Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000179 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230616 Application publication date: 20191129 Assignee: Hanli Kechuang (Wuhan) Medical Service Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000182 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230616 Application publication date: 20191129 Assignee: Wuhan Yiran Biotechnology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000181 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230616 Application publication date: 20191129 Assignee: Wuhan Youyimo Hankou Medical Management Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000184 Denomination of invention: Preparation Method and Application of Iron Tungsten Composite Oxide Nanocrystalline Clusters Granted publication date: 20210831 License type: Common License Record date: 20230616 |
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