CN110507703A - Improve the pharmaceutical composition and preparation method thereof of animal immunizing power - Google Patents
Improve the pharmaceutical composition and preparation method thereof of animal immunizing power Download PDFInfo
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- CN110507703A CN110507703A CN201910879040.0A CN201910879040A CN110507703A CN 110507703 A CN110507703 A CN 110507703A CN 201910879040 A CN201910879040 A CN 201910879040A CN 110507703 A CN110507703 A CN 110507703A
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- pharmaceutical composition
- fermented product
- radix astragali
- folium artemisiae
- artemisiae argyi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The invention discloses a kind of pharmaceutical compositions and preparation method thereof for improving animal immunizing power, include following component according to weight percent: folium artemisiae argyi grass 12~60%, Radix Astragali 5~45%, Herba Epimedii 1~38%, cortex cinnamomi 2~32%, 0.1%~10% compound probiotic agent.The present invention provides a kind of pharmaceutical compositions of herb fermenting object (folium artemisiae argyi grass, Radix Astragali, Herba Epimedii, citron and cortex cinnamomi etc.) and compound probiotic agent, its advantage that can play herb fermenting object and compound probiotic agent, it is formed complementary, the immunity of animal can be significantly improved, it is curative for effect, cost has natural advantage, can preferably serve husbandry sector.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions for improving animal immunizing power, and in particular to a kind of agent containing compound probiotic
Improve the pharmaceutical composition and preparation method thereof of animal immunizing power.
Background technique
Folium artemisiae argyi grass is bitter in taste, pungent, warm, enters spleen, liver, kidney.Compendium of Material Medica is recorded: Ai Yiye is used as medicine, warm-natured, bitter, nothing
The property of malicious, pure sun, logical 12 warp have Hui Yang, rationale blood, by raw, arresting bleeding and miscarriage prevention and other effects, and modern pharmacology finds that folium artemisiae argyi is waved
Hair oil content is more, and 1.8- Cineole (accounts for 50% or more), other to have α-absinthol, sesquiterpene alcohols and its ester.Air dried leaves contain mine
Substance 10.13%, fat 2.59%, protein 25.85% and vitamin A, B1, B2, C etc..
Radix Astragali is the Chinese medicine for being widely used in invigorating qi for strengthening superficies and promoting immunity.Herba Epimedii has kidney-replenishing, strengthening the bones and muscles, wind-dispelling
Wet Chinese medicine effect, cortex cinnamomi have supplementing Yuanyang, reinforce the effect of metabolism.
The Chinese medicines such as folium artemisiae argyi grass, Radix Astragali, Herba Epimedii, cortex cinnamomi are applied to promotion animal immunizing power model in reality and gather, In
Obtaining in treatment disease has extraordinary effect, by peculiar taste reason, in addition to Radix Astragali is widely used farm,
He is rarely used in Animal diseases and health care prevention, and does not have and significantly improve the effect of animal intestinal tract digestive function and improve
Feed conversion rate and improvement swine manure taste effect.The shortcoming of purposes based on Chinese medicine and effect thus, is specifically added
Compound probiotic agent and other additive components, are configured using different proportion, obtain different using effects.
Wherein bacillus subtilis is the prebiotic strain often added in animal feed, and animal feeding is made an addition in the form of gemma
In material.Gemma is living cells in a dormant state, the poor environment being resistant to during feed processing, after being prepared into microbial inoculum
Stablize and easily store, and can recover and breed rapidly after entering animal intestinal tract.Bacillus subtilis thalli growth process
Subtilin, polymyxins, nystatin, the gramicidins isoreactivity substance of middle generation, these active materials to pathogenic bacteria or
The conditioned pathogen of autogenous infection has apparent inhibiting effect.And there is the growth hair of stimulation animal (human body) immune organ
It educates, activates T, bone-marrow-derived lymphocyte, improve immunoglobulin and antibody level, enhance cellular immunity and humoral immune function, improve group
Body immunity.
Summary of the invention
It is excellent it is an object of the invention to solve at least the above problems and/or defect, and provide at least to will be described later
Point.
In order to realize these purposes and other advantages according to the present invention, a kind of drug for improving animal immunizing power is provided
Composition includes following component according to weight percent:
Folium artemisiae argyi grass 12~60%, Radix Astragali 5~45%, Herba Epimedii 1~38%, cortex cinnamomi 2~32%, 0.1%~10% are compound
Probiotics.
Preferably, include following component according to weight percent:
Folium artemisiae argyi grass 30%, Radix Astragali 30%, Herba Epimedii 18%, cortex cinnamomi 21%, 1% compound probiotic agent.
Preferably, the compound probiotic agent is enterococcus faecalis, saccharomyces cerevisiae, bacillus subtilis, clostridium butyricum, coagulates
Tie bacillus, enterococcus faecium it is one or more.
Preferably, the content of the compound probiotic agent >=100,000,000,000 CFU/g.
It preferably, further include the component of following percentage: 5~10% citrons, 1~3% lecithin, 0.1~0.5% egg
Propylhomoserin zinc, 0.1~0.5% taurine, 1~2% glycine betaine, 0.3~0.8% konjaku glucomannan, 0.1~0.3% sargassum thunbergii
Powder, 0.05~0.15% chitosan.
Preferably, include following component according to weight percent:
Folium artemisiae argyi grass 32%, Radix Astragali 21%, Herba Epimedii 15%, cortex cinnamomi 18%, 1% compound probiotic agent, 8% citron, 2.5%
Lecithin, 0.3% zinc methionine, 0.4% taurine, 1% glycine betaine, 0.5% konjaku glucomannan, 0.2% sargassum thunbergii powder,
0.1% chitosan.
The preparation method for the pharmaceutical composition that the present invention also provides a kind of such as above-mentioned raising animal immunizing power, including it is following
Step:
Step 1: folium artemisiae argyi grass, Radix Astragali, Herba Epimedii and cortex cinnamomi is taken to crush respectively, 50~80 meshes are crossed, medicinal material weight is separately added into
The water of 10~15 times of amount impregnates 2~3 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 30~35 DEG C, point
Not Jie Ru the good bacillus bacterium solution of preculture, inoculum concentration is volume ratio 5%, cultivates 24~28 hours, then is respectively connected to pre- training
At least one plant or more the saccharomycete bacterium solution supported, every plant of bacterium inoculum concentration are volume ratio 3%, 30 DEG C of cultivation temperature, fermentation 24~36
Hour, 100 DEG C are heated to, and kept for 10 minutes, centrifugation obtains supernatant, supernatant is concentrated under reduced pressure respectively, ethanol precipitation, sinks
Starch drying, respectively obtains folium artemisiae argyi grass fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 12~60%, Radix Astragali fermented product 5~45%, Herba Epimedii according to weight percent
Fermentation material 1~38%, Cortex Cinnamomi fermented product 2~32% and compound probiotic agent 0.1%~10% mix, and use ball mill ball milling system
Powder is improved the pharmaceutical composition of animal immunizing power.
Also a kind of preparation method of the pharmaceutical composition of such as above-mentioned raising animal immunizing power of the present invention, including following step
It is rapid:
Step I takes folium artemisiae argyi grass, Radix Astragali, Herba Epimedii, citron and cortex cinnamomi to crush respectively, crosses 50~80 meshes, is separately added into medicine
The water that 10~15 times of material weight impregnates 2~3 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；Cool the temperature to 30~35 DEG C
When, it is respectively connected to the good bacillus bacterium solution of preculture, inoculum concentration is volume ratio 5%, is cultivated 24~28 hours, then be respectively connected to
Good at least one plant or more the saccharomycete bacterium solution of preculture, every plant of bacterium inoculum concentration are volume ratio 3%, 30 DEG C of cultivation temperature, fermentation 24
~36 hours, 100 DEG C are heated to, and kept for 10 minutes, centrifugation obtains supernatant, and supernatant is concentrated under reduced pressure respectively, and ethyl alcohol is heavy
It forms sediment, sediment drying respectively obtains folium artemisiae argyi grass fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product, citron fermentation material and cortex cinnamomi hair
Ferment object；
Step 2: taking folium artemisiae argyi grass fermentation material 12~60%, Radix Astragali fermented product 5~45%, Herba Epimedii according to weight percent
Fermentation material 1~38%, citron fermentation material 5~10%, Cortex Cinnamomi fermented product 2~32%, lecithin 1~3%, zinc methionine 0.1~
0.5%, taurine 0.1~0.5%, glycine betaine 1~2%, konjaku glucomannan 0.3~0.8%, sargassum thunbergii powder 0.1~
0.3%, chitosan 0.05~0.15% and compound probiotic agent 0.1%~10% mix, and using ball mill ball powder-grinding, obtain
Improve the pharmaceutical composition of animal immunizing power.
Also a kind of application method of the pharmaceutical composition of such as above-mentioned raising animal immunizing power of the present invention, comprising: by drug
Composition is used in mixed way with feed；Described pharmaceutical composition and quality of the fodder ratio are 1~3:100~120.
The present invention is include at least the following beneficial effects: it is (folium artemisiae argyi grass, Radix Astragali, excessive that the present invention provides a kind of herb fermenting objects
The sheep leaves of pulse plants, citron and cortex cinnamomi etc.) with the pharmaceutical composition of compound probiotic agent, herb fermenting object and compound probiotic agent can be played
Advantage, formed complementary, the immunity of animal can be significantly improved, curative for effect, cost has natural advantage, can be preferably
Serve husbandry sector.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Specific embodiment:
The present invention will be further described in detail below with reference to the embodiments, to enable those skilled in the art referring to specification
Text can be implemented accordingly.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more
The presence or addition of a other elements or combinations thereof.
Embodiment 1:
A kind of pharmaceutical composition improving animal immunizing power, includes following component according to weight percent:
Folium artemisiae argyi grass 12%, Radix Astragali 35%, Herba Epimedii 20%, cortex cinnamomi 32%, 1% bacillus subtilis；The withered grass gemma
The content of bacillus >=100,000,000,000 CFU/g；
The preparation method of the pharmaceutical composition of above-mentioned raising animal immunizing power, comprising the following steps:
Step 1: folium artemisiae argyi grass, Radix Astragali, Herba Epimedii and cortex cinnamomi is taken to crush respectively, 60 meshes are crossed, medicinal material weight 15 is separately added into
Water again impregnates 3 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 35 DEG C, it is good to be respectively connected to preculture
Bacillus bacterium solution, inoculum concentration is volume ratio 5%, is cultivated 28 hours, then be respectively connected to good at least one plant or more of preculture
Saccharomycete bacterium solution, every plant of bacterium inoculum concentration are volume ratio 3%, 30 DEG C of cultivation temperature, ferment 36 hours, are heated to 100 DEG C, and keep
10 minutes, centrifugation obtained supernatant, supernatant was concentrated under reduced pressure respectively, ethanol precipitation, and sediment drying respectively obtains folium artemisiae argyi grass
Fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 12%, Radix Astragali fermented product 35%, Herba Epimedii fermented product according to weight percent
32%, Cortex Cinnamomi fermented product 32% and bacillus subtilis 1% mix, and using ball mill ball powder-grinding, are improved animal immune
The pharmaceutical composition of power.
Embodiment 2:
A kind of pharmaceutical composition improving animal immunizing power, includes following component according to weight percent:
Folium artemisiae argyi grass 18%, Radix Astragali 38%, Herba Epimedii 23%, cortex cinnamomi 20.5%, 0.5% bacillus subtilis；The withered grass
The content of bacillus >=100,000,000,000 CFU/g；
The preparation method of the pharmaceutical composition of above-mentioned raising animal immunizing power, comprising the following steps:
Step 1: folium artemisiae argyi grass, Radix Astragali, Herba Epimedii and cortex cinnamomi is taken to crush respectively, 70 meshes are crossed, medicinal material weight 12 is separately added into
Water again impregnates 2 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 35 DEG C, it is good to be respectively connected to preculture
Bacillus bacterium solution, inoculum concentration is volume ratio 5%, is cultivated 26 hours, then be respectively connected to good at least one plant or more of preculture
Saccharomycete bacterium solution, every plant of bacterium inoculum concentration are volume ratio 3%, 30 DEG C of cultivation temperature, ferment 30 hours, are heated to 100 DEG C, and keep
10 minutes, centrifugation obtained supernatant, supernatant was concentrated under reduced pressure respectively, ethanol precipitation, and sediment drying respectively obtains folium artemisiae argyi grass
Fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 18%, Radix Astragali fermented product 38%, Herba Epimedii fermented product according to weight percent
23%, Cortex Cinnamomi fermented product 20.5% and bacillus subtilis 0.5% mix, and using ball mill ball powder-grinding, are improved animal
The pharmaceutical composition of immunity.
Embodiment 3:
A kind of pharmaceutical composition improving animal immunizing power, includes following component according to weight percent:
Folium artemisiae argyi grass fermentation material 50%, Radix Astragali fermented product 30%, Herba Epimedii fermented product 10%, Cortex Cinnamomi fermented product 9%, 1% are withered
Careless bacillus；The content of the bacillus subtilis >=100,000,000,000 CFU/g；
The preparation method of the pharmaceutical composition of above-mentioned raising animal immunizing power, comprising the following steps:
Step 1: folium artemisiae argyi grass, Radix Astragali, Herba Epimedii and cortex cinnamomi is taken to crush respectively, 80 meshes are crossed, medicinal material weight 10 is separately added into
Water again impregnates 3 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 35 DEG C, it is good to be respectively connected to preculture
Bacillus bacterium solution, inoculum concentration is volume ratio 5%, is cultivated 26 hours, then be respectively connected to good at least one plant or more of preculture
Saccharomycete bacterium solution, every plant of bacterium inoculum concentration are volume ratio 3%, 30 DEG C of cultivation temperature, ferment 28 hours, are heated to 100 DEG C, and keep
10 minutes, centrifugation obtained supernatant, supernatant was concentrated under reduced pressure respectively, ethanol precipitation, and sediment drying respectively obtains folium artemisiae argyi grass
Fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 50%, Radix Astragali fermented product 30%, Herba Epimedii fermented product according to weight percent
10%, Cortex Cinnamomi fermented product 9% and bacillus subtilis 1% mix, and using ball mill ball powder-grinding, are improved animal immunizing power
Pharmaceutical composition.
Embodiment 4:
A kind of pharmaceutical composition improving animal immunizing power, includes following component according to weight percent:
Folium artemisiae argyi grass fermentation material 12%, Radix Astragali fermented product 28%, Herba Epimedii fermented product 18%, Cortex Cinnamomi fermented product 31%, 1% are withered
Careless bacillus, 5% citron, 2% lecithin, 0.5% zinc methionine, 0.5% taurine, 1% glycine betaine, 0.7% konjaku Portugal
Sweet glycan, 0.2% sargassum thunbergii powder, 0.1% chitosan；The content of the bacillus subtilis >=100,000,000,000 CFU/g；
The preparation method of the pharmaceutical composition of above-mentioned raising animal immunizing power, comprising the following steps:
Step 1: folium artemisiae argyi grass, Radix Astragali, Herba Epimedii, citron and cortex cinnamomi is taken to crush respectively, 60 meshes are crossed, medicinal material is separately added into
The water that 15 times of weight impregnates 3 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 35 DEG C, it is respectively connected to pre-
Cultured bacillus bacterium solution, inoculum concentration be volume ratio 5%, cultivate 28 hours, then be respectively connected to preculture it is good at least one
Plant or more saccharomycete bacterium solution, every plant of bacterium inoculum concentration be volume ratio 3%, 30 DEG C of cultivation temperature, ferment 36 hours, be heated to 100 DEG C,
And kept for 10 minutes, centrifugation obtains supernatant, supernatant is concentrated under reduced pressure respectively, ethanol precipitation, and sediment drying respectively obtains
Folium artemisiae argyi grass fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product, citron fermentation material and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 12%, Radix Astragali fermented product 28%, Herba Epimedii fermented product according to weight percent
18%, Cortex Cinnamomi fermented product 31%, 1% bacillus subtilis, 5% citron, 2% lecithin, 0.5% zinc methionine, 0.5% N of sulphur
Acid, the mixing of 1% glycine betaine, 0.7% konjaku glucomannan, 0.2% sargassum thunbergii powder, 0.1% chitosan, use ball mill ball milling system
Powder is improved the pharmaceutical composition of animal immunizing power.
Embodiment 5:
A kind of pharmaceutical composition improving animal immunizing power, includes following component according to weight percent:
Folium artemisiae argyi grass fermentation material 18%, Radix Astragali fermented product 30.5%, Herba Epimedii fermented product 20%, Cortex Cinnamomi fermented product 20%,
0.5% bacillus subtilis, 6% citron, 1% lecithin, 0.5% zinc methionine, 0.5% taurine, 2% glycine betaine, 0.7%
Konjaku glucomannan, 0.2% sargassum thunbergii powder, 0.1% chitosan；The content of the bacillus subtilis >=100,000,000,000 CFU/g；
The preparation method of the pharmaceutical composition of above-mentioned raising animal immunizing power, comprising the following steps:
Step 1: folium artemisiae argyi grass, Radix Astragali, Herba Epimedii, citron and cortex cinnamomi is taken to crush respectively, 70 meshes are crossed, medicinal material is separately added into
The water that 12 times of weight impregnates 2 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 35 DEG C, it is respectively connected to pre-
Cultured bacillus bacterium solution, inoculum concentration be volume ratio 5%, cultivate 26 hours, then be respectively connected to preculture it is good at least one
Plant or more saccharomycete bacterium solution, every plant of bacterium inoculum concentration be volume ratio 3%, 30 DEG C of cultivation temperature, ferment 30 hours, be heated to 100 DEG C,
And kept for 10 minutes, centrifugation obtains supernatant, supernatant is concentrated under reduced pressure respectively, ethanol precipitation, and sediment drying respectively obtains
Folium artemisiae argyi grass fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product, citron fermentation material and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 18%, Radix Astragali fermented product 30.5%, Herba Epimedii fermentation according to weight percent
Object 20%, Cortex Cinnamomi fermented product 20%, 0.5% bacillus subtilis, 6% citron, 1% lecithin, 0.5% zinc methionine, 0.5%
Taurine, 2% glycine betaine, 0.7% konjaku glucomannan, 0.2% sargassum thunbergii powder, the mixing of 0.1% chitosan, use ball mill ball
Powder-grinding is improved the pharmaceutical composition of animal immunizing power.
Embodiment 6:
A kind of pharmaceutical composition improving animal immunizing power, includes following component according to weight percent:
Folium artemisiae argyi grass fermentation material 40%, Radix Astragali fermented product 24%, Herba Epimedii fermented product 10%, Cortex Cinnamomi fermented product 9%, 1% are withered
Careless bacillus, 8% citron, 3% lecithin, 0.5% zinc methionine, 0.5% taurine, 2% glycine betaine, 0.7% konjaku Portugal
Sweet glycan, 0.2% sargassum thunbergii powder, 0.1% chitosan；The content of the bacillus subtilis >=100,000,000,000 CFU/g；
The preparation method of the pharmaceutical composition of above-mentioned raising animal immunizing power, comprising the following steps:
Step 1: folium artemisiae argyi grass, Radix Astragali, Herba Epimedii, citron and cortex cinnamomi is taken to crush respectively, 80 meshes are crossed, medicinal material is separately added into
The water that 10 times of weight impregnates 3 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 35 DEG C, it is respectively connected to pre-
Cultured bacillus bacterium solution, inoculum concentration be volume ratio 5%, cultivate 26 hours, then be respectively connected to preculture it is good at least one
Plant or more saccharomycete bacterium solution, every plant of bacterium inoculum concentration be volume ratio 3%, 30 DEG C of cultivation temperature, ferment 28 hours, be heated to 100 DEG C,
And kept for 10 minutes, centrifugation obtains supernatant, supernatant is concentrated under reduced pressure respectively, ethanol precipitation, and sediment drying respectively obtains
Folium artemisiae argyi grass fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product, citron fermentation material and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 40%, Radix Astragali fermented product 24%, Herba Epimedii fermented product according to weight percent
10%, Cortex Cinnamomi fermented product 9%, 1% bacillus subtilis, 8% citron, 3% lecithin, 0.5% zinc methionine, 0.5% N of sulphur
Acid, the mixing of 2% glycine betaine, 0.7% konjaku glucomannan, 0.2% sargassum thunbergii powder, 0.1% chitosan, use ball mill ball milling system
Powder is improved the pharmaceutical composition of animal immunizing power.
Application example:
The beneficial performance in terms of pig:
In September, 2017, applicant are connected to one pig farm response situation of Neijiang City, and key reaction growth of growing-finishing pigs is slow,
Often there is morbidity, it is not known that reason, by knowing the real situation, main problem is piggy by sickness influence, restores bad, digests and exempt from
Epidemic disease function is poor.Scene is added in 100kg feed by the pharmaceutical composition 1kg of embodiment 1 and is uniformly mixed thus, is fed,
Feeding 7 days, swinery feed intake rise, and fur is bright, the fluffy free from extraneous odour of excrement.Long-term Feeding afterwards, significant effect improve feed and turn
Rate improves 12% or more efficiency of feed utilization, and disease incidence is remarkably decreased, and using the pharmaceutical composition of embodiment 1, is on the one hand promoted
The gas of the Yuanyang of pig promotes immunity, and bacillus subtilis, which is added, improves function of intestinal canal, promotes digestion power.
In March, 2018, one home farm of Sichuan Province's Guangyuan City, feeding mother pig 50, key reaction heat is bad, it is not easy to
Breeding.By examining discovery, prevention of sow constipation, dorsal body setae is unglazed, and ambient light is bad, and cold air is heavier.Use embodiment 4
Pharmaceutical composition 2kg is added in 100 kg diets, carries out full group and feeds, and pays a return visit within 10 days, and constipation improves, and dorsal body setae improves, and sends out successively
Feelings are easy to get mating.After the amount of halving use always, observation sow state it is very good.
Use in terms of sheep:
There are more than 300 Fattening Sheeps on September 18th, 2018, the field of putting sheep out to pasture of Sichuan Province's Guangyuan City one, wherein have more fattening
Sheep, but the speed of growth is bad, is easy to generate heat sick, drove worm and be good for stomach, it is contemplated that flock of sheep are easy incidence and colony house
Low-lying humidity, 1 kilogram of pharmaceutical composition, 100 kilograms of mixed concentrate prepared by preferred embodiment 5 are used continuously one month.10 days
It was found that the excrement of sheep changes, gloss has brightness, energetic, in good condition.It will use to the end of the year always and delivers for sale.
Use in terms of broiler chicken:
2 months 2019, weather cold-dampness was heavier, led to high-volume chicken flu diarrhea, one broiler chicken pig farm of Sichuan Province's Deyang City
Help is found, has what good recipe to carry out prevention and control, the pharmaceutical composition 1kg prepared in applicant's preferred embodiment 6 is added
Fed in 100kg feed, at the same a small amount of growing way it is relatively good without feed carry out for.As a result embodiment 6 is fed
The chicken group of pharmaceutical composition not only the speed of growth is fabulous, but also without nothing any and catch a cold, the generation of diarrhea disease.Control group
It falls ill more than half, the pharmaceutical composition for then all using embodiment 6 instead is fed, and is retrieved a loss.
Clinical case 1:
1 test grouping and processing
The almost the same 1 age in days broiler chicks 300 of one farm of Sichuan Province's Guangyuan City health, weight are chosen, are randomly divided into 3
A group, every group 100；
First group is blank control group (not being administered)；
The pharmaceutical composition that the embodiment of the present invention 3 is added in the feed for nursing of second group of broiler chicks, according to every 1kg present invention
100 kilograms of Chinese medicine composition spice uses；
The pharmaceutical composition that the embodiment of the present invention 6 is added in the feed for nursing of third group broiler chicks, according to every 1kg present invention
100 kilograms of Chinese medicine composition spice uses；
Experimental period are as follows: 5~42 ages in days, to enter the young same day as 1 age in days；
According to China, large-scale broiler feeding standard preparation, daily ration are once got all the ready fastly；Test chicken is all using the double-deck cage, certainly
By searching for food and drinking water, henhouse keeps hygienically clean, well-ventilated.It weighs before test, when 42 age in days by only empty stomach, daily
Weigh broiler fodder consumption, statistical comparison each group average weight, daily gain etc..Table 2 shows test result；
Table 2
| Whole process weight gain (g) | Average daily gain (g) | |
| First group | 2095.72 | 55.15 |
| Second group | 2295.58 | 61.89 |
| Third group | 2385.65 | 62.68 |
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and example shown and described herein.
Claims (9)
1. a kind of pharmaceutical composition for improving animal immunizing power, which is characterized in that according to weight percent include following component:
Folium artemisiae argyi grass 12~60%, Radix Astragali 5~45%, Herba Epimedii 1~38%, cortex cinnamomi 2~32%, 0.1%~10% are compound prebiotic
Microbial inoculum.
2. improving the pharmaceutical composition of animal immunizing power as described in claim 1, which is characterized in that according to weight percent packet
Include following component:
Folium artemisiae argyi grass 30%, Radix Astragali 30%, Herba Epimedii 18%, cortex cinnamomi 21%, 1% compound probiotic agent.
3. improving the pharmaceutical composition of animal immunizing power as claimed in claim 1 or 2, which is characterized in that described compound prebiotic
Microbial inoculum be enterococcus faecalis, saccharomyces cerevisiae, bacillus subtilis, clostridium butyricum, bacillus coagulans, enterococcus faecium one kind or more
Kind.
4. improving the pharmaceutical composition of animal immunizing power as described in claim 1, which is characterized in that the compound probiotic agent
Content >=100,000,000,000 CFU/g.
5. improving the pharmaceutical composition of animal immunizing power as described in claim 1, which is characterized in that further include following percentage
Component: 5~10% citrons, 1~3% lecithin, 0.1~0.5% zinc methionine, 0.1~0.5% taurine, 1~2% sweet tea
Dish alkali, 0.3~0.8% konjaku glucomannan, 0.1~0.3% sargassum thunbergii powder, 0.05~0.15% chitosan.
6. improving the pharmaceutical composition of animal immunizing power as claimed in claim 5, which is characterized in that according to weight percent packet
Include following component:
Folium artemisiae argyi grass 32%, Radix Astragali 21%, Herba Epimedii 15%, cortex cinnamomi 18%, 1% compound probiotic agent, 8% citron, 2.5% lecithin
Rouge, 0.3% zinc methionine, 0.4% taurine, 1% glycine betaine, 0.5% konjaku glucomannan, 0.2% sargassum thunbergii powder, 0.1%
Chitosan.
7. a kind of preparation method of the pharmaceutical composition as described in claim 1 for improving animal immunizing power, which is characterized in that packet
Include following steps:
Step 1: folium artemisiae argyi grass, Radix Astragali, Herba Epimedii and cortex cinnamomi is taken to crush respectively, 50~80 meshes are crossed, medicinal material weight 10 is separately added into
~15 times of water impregnates 2~3 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 30~35 DEG C, connect respectively
Enter the good bacillus bacterium solution of preculture, inoculum concentration is volume ratio 5%, is cultivated 24~28 hours, then to be respectively connected to preculture good
At least one plant or more saccharomycete bacterium solution, every plant of bacterium inoculum concentration is volume ratio 3%, 30 DEG C of cultivation temperature, ferment 24~36 hours,
100 DEG C are heated to, and is kept for 10 minutes, centrifugation obtains supernatant, supernatant is concentrated under reduced pressure respectively, ethanol precipitation, sediment
Drying, respectively obtains folium artemisiae argyi grass fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 12~60%, Radix Astragali fermented product 5~45%, Herba Epimedii fermentation according to weight percent
Object 1~38%, Cortex Cinnamomi fermented product 2~32% and compound probiotic agent 0.1%~10% mix, using ball mill ball powder-grinding,
It is improved the pharmaceutical composition of animal immunizing power.
8. a kind of preparation method of the pharmaceutical composition as claimed in claim 5 for improving animal immunizing power, which is characterized in that packet
Include following steps:
Step I takes folium artemisiae argyi grass, Radix Astragali, Herba Epimedii, citron and cortex cinnamomi to crush respectively, crosses 50~80 meshes, is separately added into medicinal material weight
The water of 10~15 times of amount impregnates 2~3 hours, adjusts pH value to be 7,115 DEG C and sterilizes 60 minutes；When cooling the temperature to 30~35 DEG C, point
Not Jie Ru the good bacillus bacterium solution of preculture, inoculum concentration is volume ratio 5%, cultivates 24~28 hours, then is respectively connected to pre- training
At least one plant or more the saccharomycete bacterium solution supported, every plant of bacterium inoculum concentration are volume ratio 3%, 30 DEG C of cultivation temperature, fermentation 24~36
Hour, 100 DEG C are heated to, and kept for 10 minutes, centrifugation obtains supernatant, supernatant is concentrated under reduced pressure respectively, ethanol precipitation, sinks
Starch drying, respectively obtains folium artemisiae argyi grass fermentation material, Radix Astragali fermented product, Herba Epimedii fermented product, citron fermentation material and Cortex Cinnamomi fermented product；
Step 2: taking folium artemisiae argyi grass fermentation material 12~60%, Radix Astragali fermented product 5~45%, Herba Epimedii fermentation according to weight percent
Object 1~38%, citron fermentation material 5~10%, Cortex Cinnamomi fermented product 2~32%, lecithin 1~3%, zinc methionine 0.1~
0.5%, taurine 0.1~0.5%, glycine betaine 1~2%, konjaku glucomannan 0.3~0.8%, sargassum thunbergii powder 0.1~
0.3%, chitosan 0.05~0.15% and compound probiotic agent 0.1%~10% mix, and using ball mill ball powder-grinding, obtain
Improve the pharmaceutical composition of animal immunizing power.
9. a kind of application method of the pharmaceutical composition as claimed in claim 1 or 5 for improving animal immunizing power, feature exist
In, comprising: pharmaceutical composition and feed are used in mixed way；Described pharmaceutical composition and quality of the fodder ratio be 1~3:100~
120。
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