CN110506922A - A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose - Google Patents
A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose Download PDFInfo
- Publication number
- CN110506922A CN110506922A CN201910902694.0A CN201910902694A CN110506922A CN 110506922 A CN110506922 A CN 110506922A CN 201910902694 A CN201910902694 A CN 201910902694A CN 110506922 A CN110506922 A CN 110506922A
- Authority
- CN
- China
- Prior art keywords
- blood glucose
- adhesive
- preparation
- siraitia grosvenorii
- compound sweetener
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000003599 food sweetener Nutrition 0.000 title claims abstract description 64
- 239000003765 sweetening agent Substances 0.000 title claims abstract description 64
- 239000008280 blood Substances 0.000 title claims abstract description 47
- 210000004369 blood Anatomy 0.000 title claims abstract description 46
- 150000001875 compounds Chemical class 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 title claims abstract description 33
- 239000008103 glucose Substances 0.000 title claims abstract description 31
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 27
- 230000000087 stabilizing effect Effects 0.000 title claims abstract description 26
- 241001409321 Siraitia grosvenorii Species 0.000 title 1
- 239000000853 adhesive Substances 0.000 claims abstract description 50
- 230000001070 adhesive effect Effects 0.000 claims abstract description 50
- 239000000284 extract Substances 0.000 claims abstract description 33
- 244000185386 Thladiantha grosvenorii Species 0.000 claims abstract description 32
- 240000000249 Morus alba Species 0.000 claims abstract description 28
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 28
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 28
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 28
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 28
- 229930182490 saponin Natural products 0.000 claims abstract description 28
- 150000007949 saponins Chemical class 0.000 claims abstract description 28
- 239000000463 material Substances 0.000 claims abstract description 24
- 239000004376 Sucralose Substances 0.000 claims abstract description 22
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 claims abstract description 22
- 235000019408 sucralose Nutrition 0.000 claims abstract description 22
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 22
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940041514 candida albicans extract Drugs 0.000 claims abstract description 19
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 19
- 239000012138 yeast extract Substances 0.000 claims abstract description 19
- 238000001816 cooling Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000004321 preservation Methods 0.000 claims abstract description 13
- 239000012530 fluid Substances 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 244000269722 Thea sinensis Species 0.000 claims abstract 7
- 239000000203 mixture Substances 0.000 claims description 19
- 230000012666 negative regulation of transcription by glucose Effects 0.000 claims description 14
- 239000007921 spray Substances 0.000 claims description 13
- 239000000919 ceramic Substances 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- 229930006000 Sucrose Natural products 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- 229930182470 glycoside Natural products 0.000 claims description 7
- 150000002338 glycosides Chemical class 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 244000276331 Citrus maxima Species 0.000 claims description 2
- 235000001759 Citrus maxima Nutrition 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 150000005846 sugar alcohols Chemical class 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 240000009087 Crescentia cujete Species 0.000 claims 2
- 235000005983 Crescentia cujete Nutrition 0.000 claims 2
- 235000009797 Lagenaria vulgaris Nutrition 0.000 claims 2
- 235000014676 Phragmites communis Nutrition 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 18
- 230000008569 process Effects 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 5
- 238000005507 spraying Methods 0.000 abstract description 5
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 241001122767 Theaceae Species 0.000 description 20
- 239000012141 concentrate Substances 0.000 description 13
- 235000008504 concentrate Nutrition 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 238000013329 compounding Methods 0.000 description 9
- 239000000843 powder Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- 150000004676 glycans Chemical class 0.000 description 6
- 229920001282 polysaccharide Polymers 0.000 description 6
- 239000005017 polysaccharide Substances 0.000 description 6
- 238000011049 filling Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 229930189775 mogroside Natural products 0.000 description 5
- 230000002218 hypoglycaemic effect Effects 0.000 description 4
- 244000228451 Stevia rebaudiana Species 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 235000019605 sweet taste sensations Nutrition 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000006092 Stevia rebaudiana Nutrition 0.000 description 2
- 102000006463 Talin Human genes 0.000 description 2
- 108010083809 Talin Proteins 0.000 description 2
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 235000018927 edible plant Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 2
- QSRAJVGDWKFOGU-WBXIDTKBSA-N rebaudioside c Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]1(CC[C@H]2[C@@]3(C)[C@@H]([C@](CCC3)(C)C(=O)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)CC3)C(=C)C[C@]23C1 QSRAJVGDWKFOGU-WBXIDTKBSA-N 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 description 1
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- PVXPPJIGRGXGCY-TZLCEDOOSA-N 6-O-alpha-D-glucopyranosyl-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)C(O)(CO)O1 PVXPPJIGRGXGCY-TZLCEDOOSA-N 0.000 description 1
- 240000004246 Agave americana Species 0.000 description 1
- 235000008754 Agave americana Nutrition 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- BJHIKXHVCXFQLS-PUFIMZNGSA-N D-psicose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C(=O)CO BJHIKXHVCXFQLS-PUFIMZNGSA-N 0.000 description 1
- LXBIFEVIBLOUGU-UHFFFAOYSA-N Deoxymannojirimycin Natural products OCC1NCC(O)C(O)C1O LXBIFEVIBLOUGU-UHFFFAOYSA-N 0.000 description 1
- 239000001329 FEMA 3811 Substances 0.000 description 1
- 239000001512 FEMA 4601 Substances 0.000 description 1
- 239000001689 FEMA 4674 Substances 0.000 description 1
- 239000001776 FEMA 4720 Substances 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- HYQNKKAJVPMBDR-HIFRSBDPSA-N Hernandulcin Chemical compound CC(C)=CCC[C@](C)(O)[C@@H]1CCC(C)=CC1=O HYQNKKAJVPMBDR-HIFRSBDPSA-N 0.000 description 1
- HYQNKKAJVPMBDR-UHFFFAOYSA-N Hernandulcin Natural products CC(C)=CCCC(C)(O)C1CCC(C)=CC1=O HYQNKKAJVPMBDR-UHFFFAOYSA-N 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 description 1
- RLLCWNUIHGPAJY-RYBZXKSASA-N Rebaudioside E Natural products O=C(O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)[C@@H](O)[C@@H](O)[C@H](CO)O1)[C@]1(C)[C@@H]2[C@@](C)([C@@H]3[C@@]4(CC(=C)[C@@](O[C@@H]5[C@@H](O[C@@H]6[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O6)[C@H](O)[C@@H](O)[C@H](CO)O5)(C4)CC3)CC2)CCC1 RLLCWNUIHGPAJY-RYBZXKSASA-N 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 239000004383 Steviol glycoside Substances 0.000 description 1
- 208000025371 Taste disease Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 229930182647 Trilobatin Natural products 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002019 anti-mutation Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000013118 diabetic mouse model Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010812 external standard method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 125000003051 glycosyloxy group Chemical group 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 235000019656 metallic taste Nutrition 0.000 description 1
- 229960004329 metformin hydrochloride Drugs 0.000 description 1
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 description 1
- 235000010434 neohesperidine DC Nutrition 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 235000019203 rebaudioside A Nutrition 0.000 description 1
- RLLCWNUIHGPAJY-SFUUMPFESA-N rebaudioside E Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RLLCWNUIHGPAJY-SFUUMPFESA-N 0.000 description 1
- GSGVXNMGMKBGQU-PHESRWQRSA-N rebaudioside M Chemical compound C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13CC(=C)[C@@](C1)(CC[C@@H]23)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GSGVXNMGMKBGQU-PHESRWQRSA-N 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 235000019411 steviol glycoside Nutrition 0.000 description 1
- 229930182488 steviol glycoside Natural products 0.000 description 1
- 150000008144 steviol glycosides Chemical class 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- GSTCPEBQYSOEHV-QNDFHXLGSA-N trilobatin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C=C1O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 GSTCPEBQYSOEHV-QNDFHXLGSA-N 0.000 description 1
- DRSKVOAJKLUMCL-MMUIXFKXSA-N u2n4xkx7hp Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DRSKVOAJKLUMCL-MMUIXFKXSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/34—Sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose.Compound sweetener of the present invention includes Fructus Monordicae extract, antierythrite, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, aurantiin and Sucralose.The preparation method comprises the following steps: the raw material outside antierythrite is dissolved in hot water by (1), filter vacuum is concentrated under reduced pressure the present invention for filtering, keeps the temperature, obtains adhesive；(2) by the fluidized bed of antierythrite investment fluid bed granulator, blower is opened, and heat；(3) adhesive interval is sprayed into the fluidized bed, and material in the fluidized bed is kept to boil, be uniformly mixed；(4) after spraying into adhesive, heat preservation and dryness stands cooling, obtains compound sweetener.Siraitia grosvenorii compound sweetener of the invention, in addition to the compound sweetener itself the advantages of other than, also have and stabilize the beneficial physiological action such as blood glucose.Preparation method process stabilizing of the present invention, equipment is simple, Environmental Safety, pollution-free, is suitble to large-scale production.
Description
Technical field
The present invention relates to Siraitia grosvenorii compound sweeteners and preparation method thereof, and in particular to a kind of Siraitia grosvenorii for stabilizing blood glucose is multiple
With sweetener and preparation method thereof.
Background technique
Compound sweetener, refer to two or more natural or synthetic sweetener is compound, to reach comprehensive
Close a kind of sweetener of sweetening effects.This compounding does not instead of simply mix various sweetener monomers, in conjunction with
The technology compounding that the physilogical characteristics of synergistic effect and the sense of taste between various sweeteners carry out.
Since the sweetener of all kinds of single components cannot all meet safety, mouthfeel, technique, four Xiang Yaoqiu of cost simultaneously, all
There are different aspect, in varying degrees the shortcomings that, but by compounding, mutual disadvantage can be made up, play mutual advantage.
In addition, compounding between various sweeteners, there is likely to be synergistic effects, further promote the quality of sweetener.Therefore multiple
An important development direction of sweetener exploitation, application will be become with sweetener.
But current compound sweetener production cost, flavour mouthfeel, health-care effect and in terms of all still
In the presence of there are segmental defects.Such as:
CN102084982A discloses a kind of sweetener composition, and the composition contains Fructus Monordicae extract, STEVIA REBAUDIANA mentions
Take object, neohesperidin dihydrochalcone and auxiliary material.The inventive method causes the composition to have due to having used qualities of stevia extract
There is the defect in terms of the flavours such as rear bitter taste, metallic taste, and the composition is without nutrition health-care functions.
CN105338827A discloses a kind of composition and food, includes mogroside and antierythrite and rebaudioside
A, rebaudioside B, rebaudioside C, Stevia rebaudiana D, rebaudioside E, rebaudioside M, sucrose, monatin, Talin, not in
At least one of woods, Bu Laqiyin, l-Alanine, glycine, D-Psicose, hernandulcin, leaf stripe, trilobatin at
Point.The compound sweetener complex process, it is with high costs, it is not suitable for industrialized production.
CN103906437A discloses a kind of sweetener composition, and for mitigating diabetes, the sweetener composition contains
There are slowly digestible polysaccharide or anti-digestion polysaccharide as active constituent, further includes high intensity sweetner.Slowly digestible polysaccharide or
The anti-digestion polysaccharide includes selecting from the group being made of isomaltulose, trehalose, anti-digestion maltodextrin and oligosaccharides
At least one polysaccharide；High intensity sweetner includes from by steviol glycoside, Sucralose, aspartame, Fructus Monordicae extract, sweet
At least one high intensity sweetner selected in the group that careless extract, Talin and American aloe syrup are constituted.The sweetener
Composition heat is higher, is not suitable for diabetes patient's long-term consumption.
CN104996970A discloses a kind of compounding crystallization sweetener and preparation method thereof, and this method is successively by 0.8 weight
100-500 parts by weight water is added in part mogroside, 32-48 parts by weight antierythrite, 32-48 parts by weight isomalt
In, it mixes, filtering, obtains compound sweetener solution, then program cooling, make compound sweetener solution sufficient crystallising, finally filter,
Vacuum drying obtains compounding crystallization sweetener.The inventive method is adhered to mogroside on crystal by crystallization, there is knot
Crystalline substance must generate mother liquor, there is mother liquor inherently shrink goals ingredient, and therefore, this method is to mogroside and other auxiliary materials
Utilization rate is lower, and complex process, high production cost.
Summary of the invention
The technical problem to be solved by the present invention is to provide a kind of tool to overcome the above problem of the existing technology
There is the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect.
The present invention is further the technical problem to be solved is that, provide a kind of with the Siraitia grosvenorii compounding for stabilizing blood glucose effect
The preparation method of sweetener.Preparation method of the present invention is easy to operate, and used equipment is simple, is suitble to large-scale production.
The technical solution used to solve the technical problems of the present invention is that
It is a kind of with the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect, including following components: Fructus Monordicae extract, red moss
Sugar alcohol, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, aurantiin, Sucralose.
In the present invention, Fructus Monordicae extract derives from medicinal and edible plant --- Siraitia grosvenorii, has sugariness multiple height, zero
Heat does not improve the advantages that blood glucose level.
In the present invention, antierythrite has the spies such as sugariness is low, stability is high, heat of solution is high, solubility is high, hygroscopicity is low
Point, main function are to dilute the sugariness of the high Fructus Monordicae extract of sugariness multiple, and heat is almost nil, cool taste.
In the present invention, mulberry leaf DNJ, i.e. 1-DNJ are a kind of natural alkaloids derived from mulberry leaf, have and prolong
Slow polysaccharide degradation process reduces Postprandial peak glucose, stablizes the physiological actions such as fasting blood-glucose.DNJ has other hypoglycemic products
Incomparable advantage.
In the present invention, faenum graecum saponin(e derives from medicinal and edible plant --- faenum graecum, equally has hypoglycemic work
With, in addition there are Adjust-blood lipid, weight-reducing the effect of.
In the present invention, tea polyphenols have blood pressure lowering, anticoagulation, reducing blood lipid obesity, prevent and treat artery sclerosis, is hypoglycemic, anti-
The effects of controlling diabetes, sterilizing and anti-virus.
In the present invention, yeast extract has the function of fresh adding savoury, balance peculiar smell.
In the present invention, aurantiin has anti-inflammatory, antiviral, anticancer, antimutation, antiallergy, antiulcer, analgesia, drop blood
The effects of pressure activity, energy hypercholesterolemia, the formation for reducing thrombus, improvement local microcirculation and nutrition supply.
In the present invention, Sucralose has the characteristics that empty calory, sugariness are high, sweet taste is pure, safe, to it is puckery, bitter etc. no
Happy taste has cover effect.
In the present invention, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols synergistic effect have the function of stabilizing blood glucose.
In the present invention, faenum graecum saponin(e, tea polyphenols, yeast extract, aurantiin, Sucralose synergistic effect have and change
The effect of the rear sweet taste of kind mogroside, can make the mouthfeel of compound sweetener identical with sucrose.
Including following components preferably, by weight: 0.1~11 part of Fructus Monordicae extract, 10~95 parts of antierythrite,
0.01~10 part of mulberry leaf DNJ, 0.01~10 part of faenum graecum saponin(e, 0.01~10 part of tea polyphenols, yeast extract 0.01~10
Part, 0.01~10 part of aurantiin, 0.01~10 part of Sucralose.
Preferably, by weight, including following components: 2~20 parts of Fructus Monordicae extract, 10~95 parts of antierythrite, mulberry
0.1~0.2 part of leaf DNJ, 0.1~0.5 part of faenum graecum saponin(e, 0.1~0.5 part of tea polyphenols, 0.01~10 part of yeast extract,
0.01~10 part of aurantiin, 0.01~10 part of Sucralose.
Preferably, by weight, including following components: 2~20 parts of Fructus Monordicae extract, 60~90 parts of antierythrite, mulberry
0.1~0.2 part of leaf DNJ, 0.1~0.5 part of faenum graecum saponin(e, 0.1~0.5 part of tea polyphenols, 0.02~0.1 part of yeast extract,
0.02~0.1 part of aurantiin, 0.05~4 part of Sucralose.
Preferably, the glycosides V content in the Fructus Monordicae extract is 1.0~90.0%, and the content of the mulberry leaf DNJ is
0.5~50%, the content of the faenum graecum saponin(e is 10~50%.
Preferably, the content of the tea polyphenols is 40~99%, and the content of the aurantiin is 95~99%, the trichlorine
The content of sucrose is 98~100%
The present invention further solves its technical problem the technical scheme adopted is that a kind of with sieve for stabilizing blood glucose effect
The preparation method of Chinese fruit compound sweetener, comprising the following steps:
(1) preparation of adhesive: by Fructus Monordicae extract, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract,
Aurantiin and Sucralose mixing, obtain mixed material, and after then mixed material is dissolved in hot water, filter vacuum is depressurized in filtering
Concentration, heat preservation, obtains adhesive；
(2) it preheats: by the fluidized bed of antierythrite investment fluid bed granulator, opening blower, and heat；
(3) it sprays into adhesive: the adhesive interval in step (1) being sprayed into the fluidized bed, and keeps the fluidized bed
Interior material boiling, is uniformly mixed；
(4) dry and cooling: after having sprayed adhesive, heat preservation and dryness shuts down and stands cooling, obtains Siraitia grosvenorii compound sweetener.
Further, in step (1), the dosage of the hot water is 10~20 times of mixed material gross mass；The hot water
Temperature is 60~70 DEG C.
Further, in step (1), the filtering uses ceramic membrane filter, and the aperture of ceramic membrane is 0.05~0.5 μm.
Further, in step (1), the condition of the vacuum-concentrcted is: temperature be 60~80 DEG C, vacuum degree be-
0.06~-0.08MPa, be concentrated into solid content be 20~55% until.
Further, in step (1), the temperature of the heat preservation is 90~100 DEG C, and the time is 1~2 hour.
In the present invention, the first purpose of soak is to make to interact between each ingredient, to play its collaboration
Effect；The second purpose is sterilizing.
Further, in step (2), the temperature of the heating is 100~120 DEG C.
Further, in step (3), described adhesive is divided into be sprayed into three times, for the first time spray into adhesive total amount 40~
50%, mix 8~10min；The 20~30% of second of penetrating adhesive total amount, mix 5~10min；Third time is viscous by residue
Mixture all sprays into, and mixes 10~20min.
In the present invention, heat preservation and dryness, standing cooling can be realized by fluid bed granulator.
Compared with prior art, the invention has the following advantages: in (1) sweetener of the present invention, mulberry leaf DNJ, cucurbit
Bar saponin(e and tea polyphenols compounding have synergistic effect to blood glucose is stabilized, under lower content, still stabilize blood glucose with excellent
Effect can be used as the sucrose that sweetener substitution heat is high, sugar content is high and add in daily bread or functional health-care food, with
It is edible for diabetic population and obese people；(2) raw material that sweetener of the present invention is selected is green, environmentally friendly, safe, and nontoxic pair is made
With, alternative sucrose, and the adverse consequences such as blood glucose rise, obesity, saprodontia because of caused by sucrose will not be brought；
(3) preparation method Fructus Monordicae extract of the present invention, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, shaddock
The concentrate of the hydrothermal solution of skin glycosides and Sucralose is adhesive, so that each raw material is easier to be uniformly mixed；Further, also right
Adhesive has carried out continuing to keep the temperature, it has been investigated that, this insulating process also further promoted mulberry leaf DNJ, faenum graecum saponin(e and
Tea polyphenols three to stabilize blood glucose synergistic effect；
(4) process stabilizing of preparation method of the present invention, required equipment is simple, and Environmental Safety is pollution-free, is suitble to extensive raw
It produces.
Specific embodiment
The present invention will be described in detail by the following examples.In following embodiment, ceramic membrane is purchased from Nanjing forint moral
Environmental Protection Technology Co., Ltd；
Fluid bed granulator is purchased from Changzhou drying equipment Co., Ltd step by step；
Glycosides V content in Fructus Monordicae extract is measured by high performance liquid chromatography (HPLC) external standard method method；
Fructus Monordicae extract is purchased from Hunan Hua Cheng living resources limited liability company, and the form of Fructus Monordicae extract is concentration
Liquid or dry powder, wherein the content of glycosides V is 3.52% in Fructus Monordicae extract concentrate, and glycosides V's contains in Fructus Monordicae extract dry powder
Amount is 51.02%；
In case of no particular description, other materials is all made of ordinary commercial products.Wherein, the content of antierythrite
It is 98.25%, the content of mulberry leaf DNJ is 25.30%, and the content of faenum graecum saponin(e is 15.06%, and the content of tea polyphenols is
60.52%, the content of aurantiin is 98.72%, and the content of Sucralose is 99.96%.
Embodiment 1
A kind of preparation method of Siraitia grosvenorii compound sweetener that stabilizing blood glucose, comprising the following steps:
(1) preparation of adhesive: by 2 parts of Fructus Monordicae extract (dry powder), 0.1 part of mulberry leaf DNJ, faenum graecum saponin(e 0.2
Part, 0.2 part of tea polyphenols, 0.05 part of yeast extract, 0.05 part of aurantiin, 0.1 part of Sucralose mix to obtain mixed material, then
It is dissolved in 70 DEG C of hot water for being equivalent to 10 times of quality of mixed material, the ceramic membrane filter for being 0.1 μm with aperture, by filtrate in temperature
70 DEG C of degree, vacuum degree are concentrated under reduced pressure under conditions of being -0.07MPa, are concentrated into solid content as 30% and obtain concentrate；Concentrate is existed
Temperature is 95 DEG C, keeps the temperature 1.5 hours, obtains adhesive；
(2) it preheats: by the fluidized bed of 80 parts of antierythrite investment fluid bed granulators, opening blower, and be heated to 105
℃；
(3) it sprays into adhesive: step (1) resulting adhesive intermittently being sprayed into fluidized bed in three times, is sprayed into for the first time viscous
The 40% of mixture total amount mixes 8min；The 20% of second of penetrating adhesive total amount, mixes 6min；Third time bonds residue
Agent all sprays into, and mixes 15min.Material boiling in fluidized bed is kept, is uniformly mixed；
(4) dry and cooling: after adhesive is spraying, heat preservation and dryness shuts down and stands cooling, and it is multiple to obtain Siraitia grosvenorii of the present invention
With sweetener.
Embodiment 2
A kind of preparation method of Siraitia grosvenorii compound sweetener that stabilizing blood glucose, comprising the following steps:
(1) preparation of adhesive: by 5 parts of Fructus Monordicae extract (dry powder), 0.2 part of mulberry leaf DNJ, faenum graecum saponin(e 0.2
Part, 0.1 part of tea polyphenols, 0.1 part of yeast extract, 0.08 part of aurantiin, 0.05 part of Sucralose mix to obtain mixed material, then
It is dissolved in 65 DEG C of hot water for being equivalent to 15 times of quality of mixed material, the ceramic membrane filter for being 0.5 μm with aperture will be in temperature 75
DEG C, vacuum degree be -0.07MPa under conditions of be concentrated under reduced pressure, be concentrated into solid content be 35%, obtain concentrate；By concentrate in temperature
Degree is 100 DEG C, keeps the temperature 1 hour, obtains adhesive；
(2) it preheats: by the fluidized bed of 90 parts of antierythrite investment fluid bed granulators, opening blower, and be heated to 100
℃；
(3) it sprays into adhesive: step (1) resulting adhesive intermittently being sprayed into the fluidized bed in three times, is sprayed for the first time
Enter the 50% of adhesive total amount, mixes 10min；The 25% of second of penetrating adhesive total amount, mixes 8min；Third time will be remaining
Adhesive all sprays into, and mixes 12min.Material boiling in fluidized bed is kept, is uniformly mixed；
(4) dry and cooling: after adhesive is spraying, heat preservation and dryness shuts down and stands cooling, and it is multiple to obtain Siraitia grosvenorii of the present invention
With sweetener.
Embodiment 3
A kind of preparation method of Siraitia grosvenorii compound sweetener that stabilizing blood glucose, comprising the following steps:
(1) preparation of adhesive: by 10 parts of Fructus Monordicae extract (concentrate), 0.1 part of mulberry leaf DNJ, faenum graecum saponin(e
0.1 part, 0.1 part of tea polyphenols, 0.02 part of yeast extract, 0.02 part of aurantiin, 4 parts of the Sucralose mixed materials mixed, so
It is dissolved in 70 DEG C of hot water for being equivalent to 10 times of quality of mixed material afterwards, the ceramic membrane filter for being 0.1 μm with aperture will be in temperature
80 DEG C, vacuum degree be -0.065MPa under conditions of be concentrated under reduced pressure, be concentrated into solid content be 42% concentrate；Concentrate is existed
Temperature is 95 DEG C, keeps the temperature 2 hours, obtains adhesive；
(2) it preheats: by the fluidized bed of 60 parts of antierythrite investment fluid bed granulators, opening blower, and be heated to 105
℃；
(3) it sprays into adhesive: step (1) resulting adhesive intermittently being sprayed into fluidized bed in three times, is sprayed into for the first time viscous
The 40% of mixture total amount mixes 8min；The 20% of second of penetrating adhesive total amount, mixes 6min；Third time bonds residue
Agent all sprays into, and mixes 18min.Material boiling in fluidized bed is kept, is uniformly mixed；
(4) dry and cooling: after adhesive is spraying, heat preservation and dryness shuts down and stands cooling, and it is multiple to obtain Siraitia grosvenorii of the present invention
With sweetener.
Embodiment 4
A kind of preparation method of Siraitia grosvenorii compound sweetener that stabilizing blood glucose, comprising the following steps:
(1) preparation of adhesive: by 20 parts of Fructus Monordicae extract (concentrate), 0.15 part of mulberry leaf DNJ, faenum graecum saponin(e
0.5 part, 0.5 part of tea polyphenols, 0.1 part of yeast extract, 0.1 part of aurantiin, 2 parts of Sucralose mix to obtain mixed material, then
It is dissolved in 65 DEG C of hot water for being equivalent to 20 times of quality of mixed material, the ceramic membrane filter for being 0.5 μm with aperture will be in temperature 75
DEG C, vacuum degree be -0.07MPa under conditions of be concentrated under reduced pressure, be concentrated into solid content be 25%, concentrate；By concentrate in temperature
Degree is 98 DEG C, keeps the temperature 1 hour, obtains adhesive；
(2) it preheats: by the fluidized bed of 70 parts of antierythrite investment fluid bed granulators, opening blower, and be heated to 100
℃；
(3) it sprays into adhesive: step (1) resulting adhesive intermittently being sprayed into fluidized bed in three times, is sprayed into for the first time viscous
The 50% of mixture total amount mixes 10min；The 25% of second of penetrating adhesive total amount, mixes 8min；Third time bonds residue
Agent all sprays into, and mixes 15min.Material boiling in fluidized bed is kept, is uniformly mixed；
(4) dry and cooling: after adhesive is spraying, heat preservation and dryness shuts down and stands cooling, and it is multiple to obtain Siraitia grosvenorii of the present invention
With sweetener.
Siraitia grosvenorii compound sweetener of the present invention stabilizes hypoglycemic effect experiment:
1. the preparation of given the test agent:
Sample 1: Siraitia grosvenorii compound sweetener prepared by the embodiment of the present invention 1；
Sample 2: including 2 parts of Fructus Monordicae extract (dry powder), 0.3 part of faenum graecum saponin(e, 0.2 part of tea polyphenols, extraction from yeast
0.1 part and 80 parts 0.05 part of object, 0.05 part of aurantiin, Sucralose antierythrites, preparation side of the preparation method with embodiment 1
Method；
Sample 3: including 2 parts of Fructus Monordicae extract (dry powder), 0.3 part of mulberry leaf DNJ, 0.2 part of tea polyphenols, yeast extract
0.05 part, 0.1 part and 80 parts 0.05 part of aurantiin, Sucralose antierythrites, preparation side of the preparation method with embodiment 1
Method；
Sample 4: it is taken out including 2 parts of Fructus Monordicae extract (dry powder), 0.3 part of mulberry leaf DNJ, 0.2 part of faenum graecum saponin(e, yeast
0.1 part and 80 parts 0.05 part of extract, 0.05 part of aurantiin, Sucralose antierythrites, preparation of the preparation method with embodiment 1
Method；
Sample 5: the Siraitia grosvenorii compound sweetener that its component is prepared with embodiment 1 is identical, in preparation process not except concentrate
Experience insulating process obtains outside adhesive, remaining preparation process is identical as the preparation process of embodiment 1；
2. diabetic mouse model is established: taking KM mouse 160, randomly select 20 and be only used as Normal group, remaining is small
After mouse continuously feeds 1 week, it is deprived of food but not water 16h, injects 180mg/kg alloxan normal saline solution.Fasting 12h after 3d, tail
Extracting vein blood measures fasting blood-glucose, using blood glucose value >=11.1mmol/L as model Success criteria.
3. grouping: KM mouse being taken to be divided into Normal group (20), the physiological saline of stomach-filling corresponding amount；Modeling is successful
Mouse is randomly divided into 7 groups, is divided into model control group (20), the corresponding physiological saline of stomach-filling；1~5 group of experimental group, by 3g/kg agent
(each 20) sample 1~5 is taken in amount stomach-filling；Positive controls (20) are taken by Metformin hydrochloride 400mg/g dosage stomach-filling
With.
Normal group and model group give same amount of normal saline, daily stomach-filling 1 time, and continuous gavage 28 days.
Before taking, take 10d, 20d and 28 days detection mouse fasting blood glucose levels.Before taking for 0 time, before taking for 10 times,
Before taking for 20 times and before last takes, it is deprived of food but not water 12h, after taking 3h, orbital venous plexus takes blood, then uses grape glycosyloxy
Chemical-enzyme method measures mouse fasting blood glucose level.
4. influencing on diabetic mice fasting blood-glucose for different compound sweeteners is different, the compounding sweet taste of embodiment 1 is given
The mouse fasting blood glucose level of agent is obviously improved.Each group model mice blood glucose level is significantly raised before taking, each experimental group
Blood glucose level no significant difference.After taking 28d, model group mouse blood sugar level is high, but after the treatment of sample 1~5, blood
Sugar level has different degrees of decline, referring specifically to 1 data of table, analyzes it is found that the effect that sample 1 stabilizes blood glucose is apparently higher than
Sample 5, the effect that sample 5 stabilizes blood glucose are apparently higher than sample 2~4.As a result, it is found that mulberry in compound sweetener of the invention
Leaf DNJ, faenum graecum saponin(e and tea polyphenols have synergistic effect, stabilize blood glucose effect and are apparently higher than any two kinds of combination, make
Obtaining still has the function of stabilizing blood glucose in the case where low dose, is suitable for the sweetener as functional health-care food；This
The operation of heat preservation adhesive in invention preparation method, it helps the collaboration of mulberry leaf DNJ, faenum graecum saponin(e and tea polyphenols are made
With blood glucose is stabilized in promotion.
The different compound sweeteners of table 1 influence diabetic mice fasting blood-glucose
Compared with model group, 1) P < 0.05,2) P < 0.01；N=20.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (10)
1. a kind of Siraitia grosvenorii compound sweetener for stabilizing blood glucose, which is characterized in that including following components: Fructus Monordicae extract, red
Moss sugar alcohol, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, aurantiin and Sucralose.
2. having the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim 1, which is characterized in that by weight
Meter, including following components: 0.1~11 part of Fructus Monordicae extract, 10~95 parts of antierythrite, 0.01~10 part of mulberry leaf DNJ, calabash
0.01~10 part of reed bar saponin(e, 0.01~10 part of tea polyphenols, 0.01~10 part of yeast extract, 0.01~10 part of aurantiin and three
0.01~10 part of chlorine sucrose.
3. according to claim 1 or claim 2 have the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect, which is characterized in that by weight
Meter, including following components: 2~20 parts of Fructus Monordicae extract, 10~95 parts of antierythrite, 0.1~0.2 part of mulberry leaf DNJ, calabash
0.1~0.5 part of reed bar saponin(e, 0.1~0.5 part of tea polyphenols, 0.01~10 part of yeast extract, 0.01~10 part of aurantiin, three
0.01~10 part of chlorine sucrose.
4. having the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect described in -3 any one according to claim 1, which is characterized in that
By weight, including following components: 2~20 parts of Fructus Monordicae extract, 60~90 parts of antierythrite, mulberry leaf DNJ 0.1~0.2
Part, 0.1~0.5 part of faenum graecum saponin(e, 0.1~0.5 part of tea polyphenols, 0.02~0.1 part of yeast extract, aurantiin 0.02~
0.1 part, 0.05~4 part of Sucralose；Preferably, the glycosides V content in the Fructus Monordicae extract is 1.0~90.0%, the mulberry
The content of leaf DNJ is 0.5~50%, and the content of the faenum graecum saponin(e is 10~50%；Preferably, the content of the tea polyphenols is
40~99%, the content of the aurantiin is 95~99%, and the content of the Sucralose is 98~100%.
5. there is the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect described in claim any one of 1-4, it is special
Sign is, comprising the following steps:
(1) preparation of adhesive: by Fructus Monordicae extract, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, shaddock ped
Glycosides and Sucralose mixing, obtain mixed material, and after then mixed material is dissolved in hot water, filtering is depressurized filter vacuum dense
Contracting, heat preservation, obtains adhesive；
(2) it preheats: by the fluidized bed of antierythrite investment fluid bed granulator, opening blower, and heat；
(3) it sprays into adhesive: the interval of adhesive obtained by step (1) being sprayed into the fluidized bed, and keeps object in the fluidized bed
Material boiling, is uniformly mixed；
(4) dry and cooling: after having sprayed adhesive, heat preservation and dryness shuts down and stands cooling, obtains Siraitia grosvenorii compound sweetener.
6. having the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim 5, feature exists
In in step (1), the dosage of the hot water is 10~20 times of mixed material gross mass；Preferably, the temperature of the hot water is
60~70 DEG C；Preferably, the filtering uses ceramic membrane filter, and the aperture of ceramic membrane is 0.05~0.5 μm.
7. having the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect, feature according to claim 5 or 6
Be, the condition of the vacuum-concentrcted is: temperature is 60~80 DEG C, and vacuum degree is -0.06~-0.08MPa, is concentrated into solid
Until shape object content is 20~55%.
8. there is the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim any one of 5-7,
It is characterized in that, the temperature of the heat preservation is 90~100 DEG C in step (1), the time is 1~2 hour.
9. there is the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim any one of 5-8,
It is characterized in that, the temperature of the heating is 100~120 DEG C in step (2).
10. there is the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim any one of 5-8,
It is characterized in that, described adhesive is divided into be sprayed into three times in step (3), the 40~50% of adhesive total amount is sprayed into for the first time, is mixed
Close 8~10min；The 20~30% of second of penetrating adhesive total amount, mix 5~10min；Third time is whole by remaining adhesive
It sprays into, mixes 10~20min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910902694.0A CN110506922A (en) | 2019-09-24 | 2019-09-24 | A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910902694.0A CN110506922A (en) | 2019-09-24 | 2019-09-24 | A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110506922A true CN110506922A (en) | 2019-11-29 |
Family
ID=68633416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910902694.0A Pending CN110506922A (en) | 2019-09-24 | 2019-09-24 | A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110506922A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110897136A (en) * | 2019-12-06 | 2020-03-24 | 湖南华诚生物资源股份有限公司 | Sweetening agent compound composition capable of keeping flavor of momordica grosvenori |
| CN112042917A (en) * | 2020-09-21 | 2020-12-08 | 湖南华诚生物资源股份有限公司 | Sugar-reducing sweetener product and preparation method and application thereof |
| CN112056539A (en) * | 2020-09-21 | 2020-12-11 | 湖南华诚生物资源股份有限公司 | Preparation method of sugar-reducing sweetener |
| CN112120204A (en) * | 2020-10-27 | 2020-12-25 | 湖南华诚生物资源股份有限公司 | Sweet composition for reducing blood fat and preparation method thereof |
| CN112493459A (en) * | 2020-11-30 | 2021-03-16 | 湖南华诚生物资源股份有限公司 | Compound sweetener for improving lasting sweet taste of momordica grosvenori extract and preparation method thereof |
| CN112826072A (en) * | 2020-12-18 | 2021-05-25 | 石家庄润启生物科技有限公司 | Natural food additive |
| CN113475702A (en) * | 2021-07-20 | 2021-10-08 | 安琪酵母股份有限公司 | Natural sugar substitute yeast extract composition, preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706281A (en) * | 2004-12-09 | 2005-12-14 | 桂林莱茵生物制品有限公司 | Health food with subsidiary function of lowering blood sugar and lowering blood fat and its production process |
| US20120064218A1 (en) * | 2010-09-10 | 2012-03-15 | Sunshine Valley International Co., Ltd. | Optimized sugar substitute composition |
| JP2012060897A (en) * | 2010-09-14 | 2012-03-29 | Sunshine Valley Internatl Co Ltd | Excellent sugar substitute composition |
| CN102415548A (en) * | 2011-12-09 | 2012-04-18 | 苏州工业园区尚融科技有限公司 | Fluffy powder particle composite low-sugar and low-calorie sweetener and preparation method thereof |
| CN102429203A (en) * | 2011-12-09 | 2012-05-02 | 苏州工业园区尚融科技有限公司 | Fluffy powdery compound sugar-free sweetening agent and preparation method thereof |
| CN109198582A (en) * | 2018-08-03 | 2019-01-15 | 上海悦然生物科技有限公司 | A kind of composite sweetener and preparation method thereof |
-
2019
- 2019-09-24 CN CN201910902694.0A patent/CN110506922A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706281A (en) * | 2004-12-09 | 2005-12-14 | 桂林莱茵生物制品有限公司 | Health food with subsidiary function of lowering blood sugar and lowering blood fat and its production process |
| US20120064218A1 (en) * | 2010-09-10 | 2012-03-15 | Sunshine Valley International Co., Ltd. | Optimized sugar substitute composition |
| JP2012060897A (en) * | 2010-09-14 | 2012-03-29 | Sunshine Valley Internatl Co Ltd | Excellent sugar substitute composition |
| CN102415548A (en) * | 2011-12-09 | 2012-04-18 | 苏州工业园区尚融科技有限公司 | Fluffy powder particle composite low-sugar and low-calorie sweetener and preparation method thereof |
| CN102429203A (en) * | 2011-12-09 | 2012-05-02 | 苏州工业园区尚融科技有限公司 | Fluffy powdery compound sugar-free sweetening agent and preparation method thereof |
| CN109198582A (en) * | 2018-08-03 | 2019-01-15 | 上海悦然生物科技有限公司 | A kind of composite sweetener and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 杜红霞等: "辅助降糖保健食品的研究现状", 《中国食物与营养》 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110897136A (en) * | 2019-12-06 | 2020-03-24 | 湖南华诚生物资源股份有限公司 | Sweetening agent compound composition capable of keeping flavor of momordica grosvenori |
| CN112042917A (en) * | 2020-09-21 | 2020-12-08 | 湖南华诚生物资源股份有限公司 | Sugar-reducing sweetener product and preparation method and application thereof |
| CN112056539A (en) * | 2020-09-21 | 2020-12-11 | 湖南华诚生物资源股份有限公司 | Preparation method of sugar-reducing sweetener |
| WO2022057178A1 (en) * | 2020-09-21 | 2022-03-24 | 湖南华诚生物资源股份有限公司 | Sugar-reducing sweetener product, preparation method therefor and use thereof |
| CN112056539B (en) * | 2020-09-21 | 2023-06-16 | 湖南华诚生物资源股份有限公司 | Preparation method of sugar-reducing sweetener |
| CN112042917B (en) * | 2020-09-21 | 2023-08-25 | 湖南华诚生物资源股份有限公司 | Sugar-reducing sweetener product and preparation method and application thereof |
| CN112120204A (en) * | 2020-10-27 | 2020-12-25 | 湖南华诚生物资源股份有限公司 | Sweet composition for reducing blood fat and preparation method thereof |
| CN112493459A (en) * | 2020-11-30 | 2021-03-16 | 湖南华诚生物资源股份有限公司 | Compound sweetener for improving lasting sweet taste of momordica grosvenori extract and preparation method thereof |
| WO2022110519A1 (en) * | 2020-11-30 | 2022-06-02 | 湖南华诚生物资源股份有限公司 | Compound sweetener for improving lasting sweetness of siraitia grosvenorii extract, and preparation method therefor |
| CN112826072A (en) * | 2020-12-18 | 2021-05-25 | 石家庄润启生物科技有限公司 | Natural food additive |
| CN113475702A (en) * | 2021-07-20 | 2021-10-08 | 安琪酵母股份有限公司 | Natural sugar substitute yeast extract composition, preparation method and application thereof |
| CN113475702B (en) * | 2021-07-20 | 2022-12-16 | 安琪酵母股份有限公司 | Natural sugar substitute extract composition, preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110506922A (en) | A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose | |
| JP6779287B2 (en) | Steviol glycoside sweetener with improved flavor profile | |
| KR101852555B1 (en) | Composition for syrup containing allulose and food comprising the composition | |
| EP2215914B1 (en) | Method of improving sweetness qualities of stevia extract | |
| US11464250B2 (en) | Natural compound sweetener and preparation method therefor | |
| CN102196734B (en) | Low-calorie beverage composition containing luo han guo extract and sucralose | |
| CN100502689C (en) | Sweetener added with momordica grosvenori extract and its preparing method | |
| BR122020009091B1 (en) | METHOD TO PURIFY REB X | |
| CN107048321A (en) | RD sweetener and with the sweetened food of RD | |
| KR101603171B1 (en) | Method for producing red ginseng-concentrated granule with enhanced ginsenoside content | |
| CN110037280A (en) | Compound sweetener low in calories and preparation method thereof | |
| WO2022057178A1 (en) | Sugar-reducing sweetener product, preparation method therefor and use thereof | |
| KR20190007112A (en) | Fruit-vegetable drink | |
| CN102326815A (en) | Worm grass oral liquid and preparation method thereof | |
| WO2022088540A1 (en) | Blood lipid-lowering sweetener composition and preparation method therefor | |
| CN103549361B (en) | A kind of can be used for, contains the sweet composite sweetener of knob in areca nut food | |
| WO2013085974A2 (en) | Fatigue-relieving herbal extracts and beverages comprising the same | |
| WO2005112665A1 (en) | Composition containing processed sweet potato foliage | |
| CN107712807A (en) | A kind of preparation method of compound sweetener | |
| KR20080107924A (en) | Method for producing red-ginseng extract | |
| KR102219193B1 (en) | A composition improving quality of taste comprising allulose | |
| KR100758250B1 (en) | A method for manufacturing of drink type garlic product and drink type garlic product | |
| CN108236094A (en) | A kind of processing method of leaf dish | |
| KR101935861B1 (en) | Functional food composition for removing hangover and improving liver function and manufacturing method for thereof | |
| JPH0466543B2 (en) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191129 |