CN110506922A - A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose - Google Patents
A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose Download PDFInfo
- Publication number
- CN110506922A CN110506922A CN201910902694.0A CN201910902694A CN110506922A CN 110506922 A CN110506922 A CN 110506922A CN 201910902694 A CN201910902694 A CN 201910902694A CN 110506922 A CN110506922 A CN 110506922A
- Authority
- CN
- China
- Prior art keywords
- blood glucose
- adhesive
- preparation
- siraitia grosvenorii
- compound sweetener
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 238000002360 preparation method Methods 0.000 title claims abstract description 40
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- 239000008103 glucose Substances 0.000 title claims abstract description 31
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- 230000000087 stabilizing effect Effects 0.000 title claims abstract description 26
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/34—Sugar alcohols
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A23P10/20—Agglomerating; Granulating; Tabletting
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- A—HUMAN NECESSITIES
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Abstract
A kind of Siraitia grosvenorii compound sweetener and preparation method thereof for stabilizing blood glucose.Compound sweetener of the present invention includes Fructus Monordicae extract, antierythrite, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, aurantiin and Sucralose.The preparation method comprises the following steps: the raw material outside antierythrite is dissolved in hot water by (1), filter vacuum is concentrated under reduced pressure the present invention for filtering, keeps the temperature, obtains adhesive;(2) by the fluidized bed of antierythrite investment fluid bed granulator, blower is opened, and heat;(3) adhesive interval is sprayed into the fluidized bed, and material in the fluidized bed is kept to boil, be uniformly mixed;(4) after spraying into adhesive, heat preservation and dryness stands cooling, obtains compound sweetener.Siraitia grosvenorii compound sweetener of the invention, in addition to the compound sweetener itself the advantages of other than, also have and stabilize the beneficial physiological action such as blood glucose.Preparation method process stabilizing of the present invention, equipment is simple, Environmental Safety, pollution-free, is suitble to large-scale production.
Description
Technical field
The present invention relates to Siraitia grosvenorii compound sweeteners and preparation method thereof, and in particular to a kind of Siraitia grosvenorii for stabilizing blood glucose is multiple
With sweetener and preparation method thereof.
Background technique
Compound sweetener, refer to two or more natural or synthetic sweetener is compound, to reach comprehensive
Close a kind of sweetener of sweetening effects.This compounding does not instead of simply mix various sweetener monomers, in conjunction with
The technology compounding that the physilogical characteristics of synergistic effect and the sense of taste between various sweeteners carry out.
Since the sweetener of all kinds of single components cannot all meet safety, mouthfeel, technique, four Xiang Yaoqiu of cost simultaneously, all
There are different aspect, in varying degrees the shortcomings that, but by compounding, mutual disadvantage can be made up, play mutual advantage.
In addition, compounding between various sweeteners, there is likely to be synergistic effects, further promote the quality of sweetener.Therefore multiple
An important development direction of sweetener exploitation, application will be become with sweetener.
But current compound sweetener production cost, flavour mouthfeel, health-care effect and in terms of all still
In the presence of there are segmental defects.Such as:
CN102084982A discloses a kind of sweetener composition, and the composition contains Fructus Monordicae extract, STEVIA REBAUDIANA mentions
Take object, neohesperidin dihydrochalcone and auxiliary material.The inventive method causes the composition to have due to having used qualities of stevia extract
There is the defect in terms of the flavours such as rear bitter taste, metallic taste, and the composition is without nutrition health-care functions.
CN105338827A discloses a kind of composition and food, includes mogroside and antierythrite and rebaudioside
A, rebaudioside B, rebaudioside C, Stevia rebaudiana D, rebaudioside E, rebaudioside M, sucrose, monatin, Talin, not in
At least one of woods, Bu Laqiyin, l-Alanine, glycine, D-Psicose, hernandulcin, leaf stripe, trilobatin at
Point.The compound sweetener complex process, it is with high costs, it is not suitable for industrialized production.
CN103906437A discloses a kind of sweetener composition, and for mitigating diabetes, the sweetener composition contains
There are slowly digestible polysaccharide or anti-digestion polysaccharide as active constituent, further includes high intensity sweetner.Slowly digestible polysaccharide or
The anti-digestion polysaccharide includes selecting from the group being made of isomaltulose, trehalose, anti-digestion maltodextrin and oligosaccharides
At least one polysaccharide;High intensity sweetner includes from by steviol glycoside, Sucralose, aspartame, Fructus Monordicae extract, sweet
At least one high intensity sweetner selected in the group that careless extract, Talin and American aloe syrup are constituted.The sweetener
Composition heat is higher, is not suitable for diabetes patient's long-term consumption.
CN104996970A discloses a kind of compounding crystallization sweetener and preparation method thereof, and this method is successively by 0.8 weight
100-500 parts by weight water is added in part mogroside, 32-48 parts by weight antierythrite, 32-48 parts by weight isomalt
In, it mixes, filtering, obtains compound sweetener solution, then program cooling, make compound sweetener solution sufficient crystallising, finally filter,
Vacuum drying obtains compounding crystallization sweetener.The inventive method is adhered to mogroside on crystal by crystallization, there is knot
Crystalline substance must generate mother liquor, there is mother liquor inherently shrink goals ingredient, and therefore, this method is to mogroside and other auxiliary materials
Utilization rate is lower, and complex process, high production cost.
Summary of the invention
The technical problem to be solved by the present invention is to provide a kind of tool to overcome the above problem of the existing technology
There is the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect.
The present invention is further the technical problem to be solved is that, provide a kind of with the Siraitia grosvenorii compounding for stabilizing blood glucose effect
The preparation method of sweetener.Preparation method of the present invention is easy to operate, and used equipment is simple, is suitble to large-scale production.
The technical solution used to solve the technical problems of the present invention is that
It is a kind of with the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect, including following components: Fructus Monordicae extract, red moss
Sugar alcohol, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, aurantiin, Sucralose.
In the present invention, Fructus Monordicae extract derives from medicinal and edible plant --- Siraitia grosvenorii, has sugariness multiple height, zero
Heat does not improve the advantages that blood glucose level.
In the present invention, antierythrite has the spies such as sugariness is low, stability is high, heat of solution is high, solubility is high, hygroscopicity is low
Point, main function are to dilute the sugariness of the high Fructus Monordicae extract of sugariness multiple, and heat is almost nil, cool taste.
In the present invention, mulberry leaf DNJ, i.e. 1-DNJ are a kind of natural alkaloids derived from mulberry leaf, have and prolong
Slow polysaccharide degradation process reduces Postprandial peak glucose, stablizes the physiological actions such as fasting blood-glucose.DNJ has other hypoglycemic products
Incomparable advantage.
In the present invention, faenum graecum saponin(e derives from medicinal and edible plant --- faenum graecum, equally has hypoglycemic work
With, in addition there are Adjust-blood lipid, weight-reducing the effect of.
In the present invention, tea polyphenols have blood pressure lowering, anticoagulation, reducing blood lipid obesity, prevent and treat artery sclerosis, is hypoglycemic, anti-
The effects of controlling diabetes, sterilizing and anti-virus.
In the present invention, yeast extract has the function of fresh adding savoury, balance peculiar smell.
In the present invention, aurantiin has anti-inflammatory, antiviral, anticancer, antimutation, antiallergy, antiulcer, analgesia, drop blood
The effects of pressure activity, energy hypercholesterolemia, the formation for reducing thrombus, improvement local microcirculation and nutrition supply.
In the present invention, Sucralose has the characteristics that empty calory, sugariness are high, sweet taste is pure, safe, to it is puckery, bitter etc. no
Happy taste has cover effect.
In the present invention, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols synergistic effect have the function of stabilizing blood glucose.
In the present invention, faenum graecum saponin(e, tea polyphenols, yeast extract, aurantiin, Sucralose synergistic effect have and change
The effect of the rear sweet taste of kind mogroside, can make the mouthfeel of compound sweetener identical with sucrose.
Including following components preferably, by weight: 0.1~11 part of Fructus Monordicae extract, 10~95 parts of antierythrite,
0.01~10 part of mulberry leaf DNJ, 0.01~10 part of faenum graecum saponin(e, 0.01~10 part of tea polyphenols, yeast extract 0.01~10
Part, 0.01~10 part of aurantiin, 0.01~10 part of Sucralose.
Preferably, by weight, including following components: 2~20 parts of Fructus Monordicae extract, 10~95 parts of antierythrite, mulberry
0.1~0.2 part of leaf DNJ, 0.1~0.5 part of faenum graecum saponin(e, 0.1~0.5 part of tea polyphenols, 0.01~10 part of yeast extract,
0.01~10 part of aurantiin, 0.01~10 part of Sucralose.
Preferably, by weight, including following components: 2~20 parts of Fructus Monordicae extract, 60~90 parts of antierythrite, mulberry
0.1~0.2 part of leaf DNJ, 0.1~0.5 part of faenum graecum saponin(e, 0.1~0.5 part of tea polyphenols, 0.02~0.1 part of yeast extract,
0.02~0.1 part of aurantiin, 0.05~4 part of Sucralose.
Preferably, the glycosides V content in the Fructus Monordicae extract is 1.0~90.0%, and the content of the mulberry leaf DNJ is
0.5~50%, the content of the faenum graecum saponin(e is 10~50%.
Preferably, the content of the tea polyphenols is 40~99%, and the content of the aurantiin is 95~99%, the trichlorine
The content of sucrose is 98~100%
The present invention further solves its technical problem the technical scheme adopted is that a kind of with sieve for stabilizing blood glucose effect
The preparation method of Chinese fruit compound sweetener, comprising the following steps:
(1) preparation of adhesive: by Fructus Monordicae extract, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract,
Aurantiin and Sucralose mixing, obtain mixed material, and after then mixed material is dissolved in hot water, filter vacuum is depressurized in filtering
Concentration, heat preservation, obtains adhesive;
(2) it preheats: by the fluidized bed of antierythrite investment fluid bed granulator, opening blower, and heat;
(3) it sprays into adhesive: the adhesive interval in step (1) being sprayed into the fluidized bed, and keeps the fluidized bed
Interior material boiling, is uniformly mixed;
(4) dry and cooling: after having sprayed adhesive, heat preservation and dryness shuts down and stands cooling, obtains Siraitia grosvenorii compound sweetener.
Further, in step (1), the dosage of the hot water is 10~20 times of mixed material gross mass;The hot water
Temperature is 60~70 DEG C.
Further, in step (1), the filtering uses ceramic membrane filter, and the aperture of ceramic membrane is 0.05~0.5 μm.
Further, in step (1), the condition of the vacuum-concentrcted is: temperature be 60~80 DEG C, vacuum degree be-
0.06~-0.08MPa, be concentrated into solid content be 20~55% until.
Further, in step (1), the temperature of the heat preservation is 90~100 DEG C, and the time is 1~2 hour.
In the present invention, the first purpose of soak is to make to interact between each ingredient, to play its collaboration
Effect;The second purpose is sterilizing.
Further, in step (2), the temperature of the heating is 100~120 DEG C.
Further, in step (3), described adhesive is divided into be sprayed into three times, for the first time spray into adhesive total amount 40~
50%, mix 8~10min;The 20~30% of second of penetrating adhesive total amount, mix 5~10min;Third time is viscous by residue
Mixture all sprays into, and mixes 10~20min.
In the present invention, heat preservation and dryness, standing cooling can be realized by fluid bed granulator.
Compared with prior art, the invention has the following advantages: in (1) sweetener of the present invention, mulberry leaf DNJ, cucurbit
Bar saponin(e and tea polyphenols compounding have synergistic effect to blood glucose is stabilized, under lower content, still stabilize blood glucose with excellent
Effect can be used as the sucrose that sweetener substitution heat is high, sugar content is high and add in daily bread or functional health-care food, with
It is edible for diabetic population and obese people;(2) raw material that sweetener of the present invention is selected is green, environmentally friendly, safe, and nontoxic pair is made
With, alternative sucrose, and the adverse consequences such as blood glucose rise, obesity, saprodontia because of caused by sucrose will not be brought;
(3) preparation method Fructus Monordicae extract of the present invention, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, shaddock
The concentrate of the hydrothermal solution of skin glycosides and Sucralose is adhesive, so that each raw material is easier to be uniformly mixed;Further, also right
Adhesive has carried out continuing to keep the temperature, it has been investigated that, this insulating process also further promoted mulberry leaf DNJ, faenum graecum saponin(e and
Tea polyphenols three to stabilize blood glucose synergistic effect;
(4) process stabilizing of preparation method of the present invention, required equipment is simple, and Environmental Safety is pollution-free, is suitble to extensive raw
It produces.
Specific embodiment
The present invention will be described in detail by the following examples.In following embodiment, ceramic membrane is purchased from Nanjing forint moral
Environmental Protection Technology Co., Ltd;
Fluid bed granulator is purchased from Changzhou drying equipment Co., Ltd step by step;
Glycosides V content in Fructus Monordicae extract is measured by high performance liquid chromatography (HPLC) external standard method method;
Fructus Monordicae extract is purchased from Hunan Hua Cheng living resources limited liability company, and the form of Fructus Monordicae extract is concentration
Liquid or dry powder, wherein the content of glycosides V is 3.52% in Fructus Monordicae extract concentrate, and glycosides V's contains in Fructus Monordicae extract dry powder
Amount is 51.02%;
In case of no particular description, other materials is all made of ordinary commercial products.Wherein, the content of antierythrite
It is 98.25%, the content of mulberry leaf DNJ is 25.30%, and the content of faenum graecum saponin(e is 15.06%, and the content of tea polyphenols is
60.52%, the content of aurantiin is 98.72%, and the content of Sucralose is 99.96%.
Embodiment 1
A kind of preparation method of Siraitia grosvenorii compound sweetener that stabilizing blood glucose, comprising the following steps:
(1) preparation of adhesive: by 2 parts of Fructus Monordicae extract (dry powder), 0.1 part of mulberry leaf DNJ, faenum graecum saponin(e 0.2
Part, 0.2 part of tea polyphenols, 0.05 part of yeast extract, 0.05 part of aurantiin, 0.1 part of Sucralose mix to obtain mixed material, then
It is dissolved in 70 DEG C of hot water for being equivalent to 10 times of quality of mixed material, the ceramic membrane filter for being 0.1 μm with aperture, by filtrate in temperature
70 DEG C of degree, vacuum degree are concentrated under reduced pressure under conditions of being -0.07MPa, are concentrated into solid content as 30% and obtain concentrate;Concentrate is existed
Temperature is 95 DEG C, keeps the temperature 1.5 hours, obtains adhesive;
(2) it preheats: by the fluidized bed of 80 parts of antierythrite investment fluid bed granulators, opening blower, and be heated to 105
℃;
(3) it sprays into adhesive: step (1) resulting adhesive intermittently being sprayed into fluidized bed in three times, is sprayed into for the first time viscous
The 40% of mixture total amount mixes 8min;The 20% of second of penetrating adhesive total amount, mixes 6min;Third time bonds residue
Agent all sprays into, and mixes 15min.Material boiling in fluidized bed is kept, is uniformly mixed;
(4) dry and cooling: after adhesive is spraying, heat preservation and dryness shuts down and stands cooling, and it is multiple to obtain Siraitia grosvenorii of the present invention
With sweetener.
Embodiment 2
A kind of preparation method of Siraitia grosvenorii compound sweetener that stabilizing blood glucose, comprising the following steps:
(1) preparation of adhesive: by 5 parts of Fructus Monordicae extract (dry powder), 0.2 part of mulberry leaf DNJ, faenum graecum saponin(e 0.2
Part, 0.1 part of tea polyphenols, 0.1 part of yeast extract, 0.08 part of aurantiin, 0.05 part of Sucralose mix to obtain mixed material, then
It is dissolved in 65 DEG C of hot water for being equivalent to 15 times of quality of mixed material, the ceramic membrane filter for being 0.5 μm with aperture will be in temperature 75
DEG C, vacuum degree be -0.07MPa under conditions of be concentrated under reduced pressure, be concentrated into solid content be 35%, obtain concentrate;By concentrate in temperature
Degree is 100 DEG C, keeps the temperature 1 hour, obtains adhesive;
(2) it preheats: by the fluidized bed of 90 parts of antierythrite investment fluid bed granulators, opening blower, and be heated to 100
℃;
(3) it sprays into adhesive: step (1) resulting adhesive intermittently being sprayed into the fluidized bed in three times, is sprayed for the first time
Enter the 50% of adhesive total amount, mixes 10min;The 25% of second of penetrating adhesive total amount, mixes 8min;Third time will be remaining
Adhesive all sprays into, and mixes 12min.Material boiling in fluidized bed is kept, is uniformly mixed;
(4) dry and cooling: after adhesive is spraying, heat preservation and dryness shuts down and stands cooling, and it is multiple to obtain Siraitia grosvenorii of the present invention
With sweetener.
Embodiment 3
A kind of preparation method of Siraitia grosvenorii compound sweetener that stabilizing blood glucose, comprising the following steps:
(1) preparation of adhesive: by 10 parts of Fructus Monordicae extract (concentrate), 0.1 part of mulberry leaf DNJ, faenum graecum saponin(e
0.1 part, 0.1 part of tea polyphenols, 0.02 part of yeast extract, 0.02 part of aurantiin, 4 parts of the Sucralose mixed materials mixed, so
It is dissolved in 70 DEG C of hot water for being equivalent to 10 times of quality of mixed material afterwards, the ceramic membrane filter for being 0.1 μm with aperture will be in temperature
80 DEG C, vacuum degree be -0.065MPa under conditions of be concentrated under reduced pressure, be concentrated into solid content be 42% concentrate;Concentrate is existed
Temperature is 95 DEG C, keeps the temperature 2 hours, obtains adhesive;
(2) it preheats: by the fluidized bed of 60 parts of antierythrite investment fluid bed granulators, opening blower, and be heated to 105
℃;
(3) it sprays into adhesive: step (1) resulting adhesive intermittently being sprayed into fluidized bed in three times, is sprayed into for the first time viscous
The 40% of mixture total amount mixes 8min;The 20% of second of penetrating adhesive total amount, mixes 6min;Third time bonds residue
Agent all sprays into, and mixes 18min.Material boiling in fluidized bed is kept, is uniformly mixed;
(4) dry and cooling: after adhesive is spraying, heat preservation and dryness shuts down and stands cooling, and it is multiple to obtain Siraitia grosvenorii of the present invention
With sweetener.
Embodiment 4
A kind of preparation method of Siraitia grosvenorii compound sweetener that stabilizing blood glucose, comprising the following steps:
(1) preparation of adhesive: by 20 parts of Fructus Monordicae extract (concentrate), 0.15 part of mulberry leaf DNJ, faenum graecum saponin(e
0.5 part, 0.5 part of tea polyphenols, 0.1 part of yeast extract, 0.1 part of aurantiin, 2 parts of Sucralose mix to obtain mixed material, then
It is dissolved in 65 DEG C of hot water for being equivalent to 20 times of quality of mixed material, the ceramic membrane filter for being 0.5 μm with aperture will be in temperature 75
DEG C, vacuum degree be -0.07MPa under conditions of be concentrated under reduced pressure, be concentrated into solid content be 25%, concentrate;By concentrate in temperature
Degree is 98 DEG C, keeps the temperature 1 hour, obtains adhesive;
(2) it preheats: by the fluidized bed of 70 parts of antierythrite investment fluid bed granulators, opening blower, and be heated to 100
℃;
(3) it sprays into adhesive: step (1) resulting adhesive intermittently being sprayed into fluidized bed in three times, is sprayed into for the first time viscous
The 50% of mixture total amount mixes 10min;The 25% of second of penetrating adhesive total amount, mixes 8min;Third time bonds residue
Agent all sprays into, and mixes 15min.Material boiling in fluidized bed is kept, is uniformly mixed;
(4) dry and cooling: after adhesive is spraying, heat preservation and dryness shuts down and stands cooling, and it is multiple to obtain Siraitia grosvenorii of the present invention
With sweetener.
Siraitia grosvenorii compound sweetener of the present invention stabilizes hypoglycemic effect experiment:
1. the preparation of given the test agent:
Sample 1: Siraitia grosvenorii compound sweetener prepared by the embodiment of the present invention 1;
Sample 2: including 2 parts of Fructus Monordicae extract (dry powder), 0.3 part of faenum graecum saponin(e, 0.2 part of tea polyphenols, extraction from yeast
0.1 part and 80 parts 0.05 part of object, 0.05 part of aurantiin, Sucralose antierythrites, preparation side of the preparation method with embodiment 1
Method;
Sample 3: including 2 parts of Fructus Monordicae extract (dry powder), 0.3 part of mulberry leaf DNJ, 0.2 part of tea polyphenols, yeast extract
0.05 part, 0.1 part and 80 parts 0.05 part of aurantiin, Sucralose antierythrites, preparation side of the preparation method with embodiment 1
Method;
Sample 4: it is taken out including 2 parts of Fructus Monordicae extract (dry powder), 0.3 part of mulberry leaf DNJ, 0.2 part of faenum graecum saponin(e, yeast
0.1 part and 80 parts 0.05 part of extract, 0.05 part of aurantiin, Sucralose antierythrites, preparation of the preparation method with embodiment 1
Method;
Sample 5: the Siraitia grosvenorii compound sweetener that its component is prepared with embodiment 1 is identical, in preparation process not except concentrate
Experience insulating process obtains outside adhesive, remaining preparation process is identical as the preparation process of embodiment 1;
2. diabetic mouse model is established: taking KM mouse 160, randomly select 20 and be only used as Normal group, remaining is small
After mouse continuously feeds 1 week, it is deprived of food but not water 16h, injects 180mg/kg alloxan normal saline solution.Fasting 12h after 3d, tail
Extracting vein blood measures fasting blood-glucose, using blood glucose value >=11.1mmol/L as model Success criteria.
3. grouping: KM mouse being taken to be divided into Normal group (20), the physiological saline of stomach-filling corresponding amount;Modeling is successful
Mouse is randomly divided into 7 groups, is divided into model control group (20), the corresponding physiological saline of stomach-filling;1~5 group of experimental group, by 3g/kg agent
(each 20) sample 1~5 is taken in amount stomach-filling;Positive controls (20) are taken by Metformin hydrochloride 400mg/g dosage stomach-filling
With.
Normal group and model group give same amount of normal saline, daily stomach-filling 1 time, and continuous gavage 28 days.
Before taking, take 10d, 20d and 28 days detection mouse fasting blood glucose levels.Before taking for 0 time, before taking for 10 times,
Before taking for 20 times and before last takes, it is deprived of food but not water 12h, after taking 3h, orbital venous plexus takes blood, then uses grape glycosyloxy
Chemical-enzyme method measures mouse fasting blood glucose level.
4. influencing on diabetic mice fasting blood-glucose for different compound sweeteners is different, the compounding sweet taste of embodiment 1 is given
The mouse fasting blood glucose level of agent is obviously improved.Each group model mice blood glucose level is significantly raised before taking, each experimental group
Blood glucose level no significant difference.After taking 28d, model group mouse blood sugar level is high, but after the treatment of sample 1~5, blood
Sugar level has different degrees of decline, referring specifically to 1 data of table, analyzes it is found that the effect that sample 1 stabilizes blood glucose is apparently higher than
Sample 5, the effect that sample 5 stabilizes blood glucose are apparently higher than sample 2~4.As a result, it is found that mulberry in compound sweetener of the invention
Leaf DNJ, faenum graecum saponin(e and tea polyphenols have synergistic effect, stabilize blood glucose effect and are apparently higher than any two kinds of combination, make
Obtaining still has the function of stabilizing blood glucose in the case where low dose, is suitable for the sweetener as functional health-care food;This
The operation of heat preservation adhesive in invention preparation method, it helps the collaboration of mulberry leaf DNJ, faenum graecum saponin(e and tea polyphenols are made
With blood glucose is stabilized in promotion.
The different compound sweeteners of table 1 influence diabetic mice fasting blood-glucose
Compared with model group, 1) P < 0.05,2) P < 0.01;N=20.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (10)
1. a kind of Siraitia grosvenorii compound sweetener for stabilizing blood glucose, which is characterized in that including following components: Fructus Monordicae extract, red
Moss sugar alcohol, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, aurantiin and Sucralose.
2. having the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim 1, which is characterized in that by weight
Meter, including following components: 0.1~11 part of Fructus Monordicae extract, 10~95 parts of antierythrite, 0.01~10 part of mulberry leaf DNJ, calabash
0.01~10 part of reed bar saponin(e, 0.01~10 part of tea polyphenols, 0.01~10 part of yeast extract, 0.01~10 part of aurantiin and three
0.01~10 part of chlorine sucrose.
3. according to claim 1 or claim 2 have the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect, which is characterized in that by weight
Meter, including following components: 2~20 parts of Fructus Monordicae extract, 10~95 parts of antierythrite, 0.1~0.2 part of mulberry leaf DNJ, calabash
0.1~0.5 part of reed bar saponin(e, 0.1~0.5 part of tea polyphenols, 0.01~10 part of yeast extract, 0.01~10 part of aurantiin, three
0.01~10 part of chlorine sucrose.
4. having the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect described in -3 any one according to claim 1, which is characterized in that
By weight, including following components: 2~20 parts of Fructus Monordicae extract, 60~90 parts of antierythrite, mulberry leaf DNJ 0.1~0.2
Part, 0.1~0.5 part of faenum graecum saponin(e, 0.1~0.5 part of tea polyphenols, 0.02~0.1 part of yeast extract, aurantiin 0.02~
0.1 part, 0.05~4 part of Sucralose;Preferably, the glycosides V content in the Fructus Monordicae extract is 1.0~90.0%, the mulberry
The content of leaf DNJ is 0.5~50%, and the content of the faenum graecum saponin(e is 10~50%;Preferably, the content of the tea polyphenols is
40~99%, the content of the aurantiin is 95~99%, and the content of the Sucralose is 98~100%.
5. there is the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect described in claim any one of 1-4, it is special
Sign is, comprising the following steps:
(1) preparation of adhesive: by Fructus Monordicae extract, mulberry leaf DNJ, faenum graecum saponin(e, tea polyphenols, yeast extract, shaddock ped
Glycosides and Sucralose mixing, obtain mixed material, and after then mixed material is dissolved in hot water, filtering is depressurized filter vacuum dense
Contracting, heat preservation, obtains adhesive;
(2) it preheats: by the fluidized bed of antierythrite investment fluid bed granulator, opening blower, and heat;
(3) it sprays into adhesive: the interval of adhesive obtained by step (1) being sprayed into the fluidized bed, and keeps object in the fluidized bed
Material boiling, is uniformly mixed;
(4) dry and cooling: after having sprayed adhesive, heat preservation and dryness shuts down and stands cooling, obtains Siraitia grosvenorii compound sweetener.
6. having the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim 5, feature exists
In in step (1), the dosage of the hot water is 10~20 times of mixed material gross mass;Preferably, the temperature of the hot water is
60~70 DEG C;Preferably, the filtering uses ceramic membrane filter, and the aperture of ceramic membrane is 0.05~0.5 μm.
7. having the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect, feature according to claim 5 or 6
Be, the condition of the vacuum-concentrcted is: temperature is 60~80 DEG C, and vacuum degree is -0.06~-0.08MPa, is concentrated into solid
Until shape object content is 20~55%.
8. there is the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim any one of 5-7,
It is characterized in that, the temperature of the heat preservation is 90~100 DEG C in step (1), the time is 1~2 hour.
9. there is the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim any one of 5-8,
It is characterized in that, the temperature of the heating is 100~120 DEG C in step (2).
10. there is the preparation method for the Siraitia grosvenorii compound sweetener for stabilizing blood glucose effect according to claim any one of 5-8,
It is characterized in that, described adhesive is divided into be sprayed into three times in step (3), the 40~50% of adhesive total amount is sprayed into for the first time, is mixed
Close 8~10min;The 20~30% of second of penetrating adhesive total amount, mix 5~10min;Third time is whole by remaining adhesive
It sprays into, mixes 10~20min.
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CN112493459A (en) * | 2020-11-30 | 2021-03-16 | 湖南华诚生物资源股份有限公司 | Compound sweetener for improving lasting sweet taste of momordica grosvenori extract and preparation method thereof |
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