CN110448629B - Traditional Chinese medicine composition for treating constipation - Google Patents
Traditional Chinese medicine composition for treating constipation Download PDFInfo
- Publication number
- CN110448629B CN110448629B CN201910800943.5A CN201910800943A CN110448629B CN 110448629 B CN110448629 B CN 110448629B CN 201910800943 A CN201910800943 A CN 201910800943A CN 110448629 B CN110448629 B CN 110448629B
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- traditional chinese
- chinese medicine
- constipation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition for treating constipation, which is prepared from 10-30 parts by weight of rhubarb, 10-30 parts by weight of mirabilite, 10-30 parts by weight of immature bitter orange, 10-30 parts by weight of officinal magnolia bark, 10-30 parts by weight of costus root and 10-30 parts by weight of betel nut. The traditional Chinese medicine composition disclosed by the invention has an excellent effect on treating functional constipation by selecting appropriate traditional Chinese medicinal materials and reasonably combining the traditional Chinese medicinal materials.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine for treating constipation.
Background
Functional Constipation (FC) is a common disease of the digestive system, and is a group of symptoms without obvious organic lesions and mainly manifested by reduced defecation frequency, reduced stool volume, dry stool and hard defecation. Epidemiological data show that the incidence rate of constipation in China is 3% -17%. The incidence rate of chronic functional constipation in 18-70 years old people in Beijing area of China is 6.07%. With the accelerated development of our society, the pace of life of people is increasingly accelerated, the emotional tension degree is increased by the competitive pressure, and the incidence of functional constipation is increased year by year under the influence of various comprehensive factors such as increasingly refined dietary structure and the like, thereby seriously influencing the life quality of modern people. Constipation can not only cause the occurrence of anal diseases such as hemorrhoids, fissures and the like, but also induce and aggravate various cardiovascular and cerebrovascular diseases, even induce colon cancer seriously, and endanger life.
Currently, functional constipation is internationally classified into three types according to the site where constipation occurs and the dynamic characteristics of the colon: slow transit constipation, outlet obstruction constipation, and hybrid constipation, wherein the incidence of slow transit constipation is the highest. Slow transit constipation is constipation caused by a colonic motility disorder resulting in slow discharge of intestinal contents or retention in the colon. Constipation of the outlet obstruction type is constipation caused by abnormality of anus and rectum due to non-organic factors, but the colon dynamics and functions are normal.
As the human society continues to advance, increasingly fine diets have resulted in a decrease in dietary fiber intake; the pace of life is accelerated, so that people generally lack of movement; the public health care knowledge is absent, and a lot of people can easily take the defecate at any time; abuse of laxatives and the like all contribute to the onset of functional constipation. With the transition from the traditional biomedical mode to the biological-psychological-social medical mode, the research on the disease onset increasingly refers to psychological and social factors, and in recent years, the psychopsychological factors are found to be one of the high-risk factors causing functional constipation. Researchers use life event scales and symptom self-rating scales to carry out psychological tests on functional constipation patient groups and healthy people groups, and the obtained psychology factors are one of the factors for the onset of functional constipation.
The traditional Chinese medicine has long known constipation, and constipation is known by various names in ancient medical book, including spleen, yang and yin, wherein the earliest records are in the Huangdi's classic on constipation. The traditional Chinese medicine considers that the food is drunk by people in the stomach and transported and transformed by the spleen and stomach, food essence is used by the body, and the residual dregs are conducted from the large intestine and discharged out of the body through the soul, wherein the dregs are the excrement. For instance, if the spleen and stomach function of transportation and transformation is healthy and the large intestine conducts normally, the stool is natural and smooth, wherein the function of large intestine conduction is the key to normal defecation, as stated in Huangdi's classic questions: the large intestine, the organ of conduction, is so designed. Improper diet, emotional disorder or weakness and fatigue cause dysfunction of viscera, which may cause dysfunction of spleen and stomach in transportation and transformation, dysfunction of large intestine in conduction, dregs in intestinal tract, accumulation for a long time, hard and dry feces, difficult to emerge and constipation.
The treatment of functional constipation is generally based on syndrome differentiation, the disease location of constipation is in the large intestine, and is closely related to the dysfunction of spleen, stomach, liver, kidney and other viscera, and the pathological nature of constipation includes four aspects of deficiency, excess, cold and heat. Therefore, in treatment, deficiency and excess are first distinguished, and then cold and heat are distinguished. The excess secret is classified into heat secret and qi secret, the heat secret can clear heat and moisten intestines, and the recipe is modified by fructus Cannabis pill; modified Liumo Tang is used for the recipe for qi stagnation. The formula is modified with Huangqi decoction for treating constipation due to deficiency syndrome manifested as qi deficiency, blood deficiency, yin deficiency and yang deficiency, or qi deficiency and constipation; for constipation due to blood deficiency, blood-nourishing and dryness-moistening, modified Changchun Wan is used in the recipe; for constipation due to yin deficiency, add or subtract Zengye Tang in the recipe; for constipation due to yang deficiency, it is added or subtracted with Jichuan decoction.
The radix et rhizoma Rhei is rhizome of Rheum palmatum L., Rheum tanguticum Maxim. or Rheum officinale Baill. of Polygonaceae, and is used for spleen, stomach, large intestine, liver and pericardium channels. Rhubarb, radix et rhizoma Rhei purges heat and unblocks intestines, cools blood and detoxifies, dispels blood stasis and promotes menstruation, and is mainly used for excess heat constipation, accumulated abdominal pain, dyschezia, damp-heat jaundice, blood heat hematemesis and epistaxis, conjunctival congestion, pharyngeal swelling, intestinal carbuncle abdominal pain, carbuncle swelling and furuncle, blood stasis amenorrhea, traumatic injury and external treatment of water and fire scald; upper gastrointestinal hemorrhage.
The mirabilite is crystal which is prepared by processing and refining sulfate mineral mirabilite of mirabilite family, and enters stomach and large intestine channels. Natrii sulfas has effects of clearing heat, relaxing bowels, moistening dryness, softening hard masses, clearing pathogenic fire and relieving swelling, and is mainly used for excess heat constipation, abdominal pain due to stagnation, and intestinal abscess with swelling and pain; it is indicated for acute mastitis, hemorrhoid with swelling and pain.
The fructus Aurantii Immaturus is young fruit of Poncirus trifoliata, Citrus aurantium or Citrus aurantium of Rutaceae, and enters spleen and stomach channels. Immature bitter orange has the effects of breaking qi and removing food retention, and resolving phlegm and dispersing mass, and is mainly used for stagnation and stagnation, mass and fullness and distending pain, diarrhea and dysentery with heaviness, constipation, phlegm stagnation and qi obstruction in chest and chest stagnation; gastroptosis, rectocele, uterine prolapse.
Hou Po is bitter and pungent in flavor and warm in nature, entering the stomach meridian of foot yangming. Hou Po can lower Chong and checking cough, break and obstruct obstruction to relieve dyspnea, relieve pain and relieve fullness in chest.
Radix aucklandiae is dried root of Compositae plant radix aucklandiae, and is effective in invigorating spleen, stomach, large intestine, triple warmer, and gallbladder channel. Mu Xiang can move qi and alleviate pain, invigorate spleen and promote digestion, and is mainly indicated for distending pain in chest and epigastrium, diarrhea and dysentery, food stagnation and anorexia. Roasted mu Xiang can relieve diarrhea and abdominal pain.
Arecae semen is the dried mature seed of Arecae semen of Palmae, and enters stomach and large intestine meridians. Areca catechu kills parasites and removes food retention, lowers qi, moves water and intercepts malaria, and is mainly used for tapeworm, ascarid and fasciolopsiasis, abdominal pain due to parasitic infestation, stagnation and diarrhea, tenesmus, edema and beriberi and malaria.
The radix Cynanchi Paniculati is root and rhizome of Cynanchum Paniculatum of Asclepiadaceae or whole plant with root, and enters liver and stomach channels. The paniculate swallowwort root has the effects of easing pain, relieving cough, inducing diuresis to alleviate edema, promoting blood circulation and removing toxicity, and is mainly used for treating stomachache, toothache, rheumatic pain, menstrual abdominal pain, chronic tracheitis, ascites, edema, dysentery, enteritis, traumatic injury, eczema, urticaria and venomous snake bite.
Ramulus Uncariae cum uncis is ramulus Uncariae cum uncis of Rubiaceae, ramulus Uncariae cum uncis of the same genus, and enters liver and pericardium channels. Ramulus Uncariae cum uncis has effects of clearing heat and calming liver, calming endogenous wind and arresting convulsion, and can be used for treating headache, giddiness, common cold with convulsion, convulsive epilepsy, convulsion, gestational eclampsia, hypertension, etc.
At present, no report related to the use of the traditional Chinese medicine composition for treating functional constipation exists.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition which can effectively treat functional constipation and has low toxic and side effects.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a traditional Chinese medicine composition for treating constipation, which is prepared from rhubarb, mirabilite, immature bitter orange, magnolia officinalis, costustoot and areca nut.
Preferably, the traditional Chinese medicine composition is prepared from 10-30 parts by weight of rhubarb, 10-30 parts by weight of mirabilite, 10-30 parts by weight of immature bitter orange, 10-30 parts by weight of magnolia officinalis, 10-30 parts by weight of costus root and 10-30 parts by weight of betel nut.
More preferably, the traditional Chinese medicine composition is prepared from 15-25 parts by weight of rhubarb, 15-25 parts by weight of mirabilite, 15-25 parts by weight of immature bitter orange, 15-25 parts by weight of magnolia officinalis, 15-25 parts by weight of costus root and 15-25 parts by weight of betel nut.
Further preferably, the traditional Chinese medicine composition is prepared from 10 parts by weight of rhubarb, 10 parts by weight of mirabilite, 10 parts by weight of immature bitter orange, 10 parts by weight of magnolia officinalis, 10 parts by weight of costus root and 10 parts by weight of betel nut.
Preferably, the traditional Chinese medicine composition further comprises one or more of paniculate swallowwort root and uncaria. More preferably, the traditional Chinese medicine composition further comprises paniculate swallowwort root and uncaria.
Further preferably, the traditional Chinese medicine composition is prepared from 10 parts by weight of rheum officinale, 10 parts by weight of mirabilite, 10 parts by weight of immature bitter orange, 10 parts by weight of mangnolia officinalis, 10 parts by weight of elecampane, 10 parts by weight of areca nut, 1-10 parts by weight of cynanchum paniculatum and 1-10 parts by weight of uncaria.
Most preferably, the traditional Chinese medicine composition is prepared from 10 parts by weight of rheum officinale, 10 parts by weight of mirabilite, 10 parts by weight of immature bitter orange, 10 parts by weight of mangnolia officinalis, 10 parts by weight of elecampane, 10 parts by weight of areca nut, 5 parts by weight of cynanchum paniculatum and 5 parts by weight of uncaria.
The second aspect of the present invention provides a preparation method of the above traditional Chinese medicine composition, comprising the following steps: the traditional Chinese medicines with the prescription dose are respectively ground into fine powder and then fully mixed, the fine powder is sieved by a 80-mesh sieve, and proper amount of vaseline is added for even mixing, thus obtaining the traditional Chinese medicine composition.
Preferably, the weight ratio of the traditional Chinese medicine to the vaseline is 1 (1-2).
The third aspect of the invention provides an application of the traditional Chinese medicine composition in preparing a medicine for treating constipation.
Preferably, the constipation is functional constipation.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for accelerating the colon myoelectric slow wave frequency.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for increasing the amplitude of colon myoelectric slow waves.
The invention has the positive and beneficial effects that:
repeated experiments show that the combination of rhubarb, mirabilite, immature bitter orange, magnolia officinalis, costus root and betel nut according to a specific proportion has an excellent effect on treating functional constipation, and the effect is better when the combination is matched with traditional Chinese medicines such as paniculate swallowwort root and uncaria.
Detailed Description
The present invention will be further described with reference to the following examples, but the embodiments of the present invention are not limited thereto. The experimental procedures used in the following examples are all conventional procedures unless otherwise specified.
Example 1
10g of rhubarb, 10g of mirabilite, 10g of immature bitter orange, 10g of magnolia officinalis, 10g of costustoot and 10g of betel nut are respectively ground into fine powder and then are fully mixed, the mixture is sieved by a 80-mesh sieve, and 100g of vaseline is added and uniformly mixed to obtain the traditional Chinese medicine ointment O1.
Example 2
Grinding 5g of rhubarb, 5g of mirabilite, 15g of immature bitter orange, 15g of magnolia officinalis, 10g of elecampane and 10g of betel nut into fine powder respectively, fully mixing, sieving by a 80-mesh sieve, and adding 100g of vaseline to mix uniformly to obtain the traditional Chinese medicine ointment O2.
Example 3
10g of rhubarb, 10g of mirabilite, 5g of immature bitter orange, 5g of magnolia officinalis, 15g of costustoot and 15g of areca nut are respectively ground into fine powder and then are fully mixed, the fine powder is sieved by a 80-mesh sieve, and 100g of vaseline is added and uniformly mixed to obtain the traditional Chinese medicine ointment O3.
Example 4
Taking 15g of rhubarb, 15g of mirabilite, 10g of immature bitter orange, 10g of magnolia officinalis, 5g of costustoot and 5g of areca nut, grinding the raw materials into fine powder respectively, fully mixing the fine powder, sieving the fine powder by a 80-mesh sieve, and adding 100g of vaseline to mix uniformly to obtain the traditional Chinese medicine ointment O4.
Example 5
10g of rhubarb, 10g of mirabilite, 10g of immature bitter orange, 10g of magnolia officinalis, 10g of costustoot, 10g of betel nut and 10g of paniculate swallowwort root are respectively ground into fine powder and then are fully mixed, the fine powder is sieved by a 80-mesh sieve, and 100g of vaseline is added and uniformly mixed to obtain the traditional Chinese medicine ointment O5.
Example 6
10g of rhubarb, 10g of mirabilite, 10g of immature bitter orange, 10g of magnolia officinalis, 10g of costustoot, 10g of areca and 10g of uncaria are respectively ground into fine powder and then fully mixed, the fine powder is sieved by a 80-mesh sieve, and 100g of vaseline is added and uniformly mixed to obtain the traditional Chinese medicine ointment O6.
Example 7
The preparation method comprises the following steps of grinding 10g of rheum officinale, 10g of mirabilite, 10g of immature bitter orange, 10g of mangnolia officinalis, 10g of elecampane, 10g of betel nut, 5g of paniculate swallowwort root and 5g of uncaria into fine powder respectively, fully mixing, sieving with a 80-mesh sieve, and adding 100g of vaseline for uniformly mixing to obtain the traditional Chinese medicine ointment O7.
Test example 1: therapeutic effect of traditional Chinese medicine composition on functional constipation model rats
1. Test grouping and animal model preparation
Healthy SD rats are fed with basal feed adaptively for 1 week, and are randomly divided into 9 groups according to body constitution, namely a normal control group, a model group and 1-7 groups of the traditional Chinese medicine composition (namely the traditional Chinese medicine composition prepared in the embodiment 1-7 of the invention) in sequence, wherein each group comprises 10 animals. And fasting is not forbidden for 24 hours in the morning before the molding is carried out. Except for the normal control group, the other groups were administered daily gavage with compound diphenoxylate suspension (20mg/kg) for 2 weeks. After the model building is successful, the rats of the normal control group and the model group are gazed with 2mL of physiological saline; the Chinese medicinal composition 1-7 groups of rats are subjected to intragastric administration for 2mL by using the Chinese medicinal composition 1-7 (Chinese medicaments without vaseline are added into distilled water in a subdivided manner to prepare intragastric administration liquid medicine of 200 mg/mL), and the administration is carried out for 7 days and 1 time every day.
2. Test method
2.1 Observation of defecation amount
After the last treatment administration, the body mass is measured, animals are fasted and are not forbidden to drink for 12 hours, rats are placed in a metabolic cage one by one for observation, and the total defecation amount of the rats within 8 hours is recorded.
2.2 in vivo Colon myoelectric detection
After the molding is finished, the animals are fasted for 18 hours without water prohibition, and 100g/L chloral hydrate solution is used for intraperitoneal injection anesthesia (4 mL/kg). Fixing the rat in a supine position on an operating table, unhairing the abdomen, disinfecting the rat by a conventional method, opening the abdomen, exposing a colon section, enabling a lead to pass through an intestinal wall muscle layer and enabling a naked metal wire to stay on the intestinal wall muscle layer to serve as a recording electrode, inserting another electrode at a distance of 1cm, respectively connecting 2 electrodes with the positive electrode and the negative electrode of a PowerLab recorder, inserting a reference electrode under the skin of the left forelimb of the rat, and recording the change of the colon myoelectricity of the rat by a Power Lab data acquisition system. 2 colon electromyographic waves were randomly selected from the recorded results for each animal, and the mean values of the frequency and amplitude of each wave were counted using a PowerLab data analysis system.
3. Test results
The effect of the traditional Chinese medicine composition on the defecation quantity of the functional constipation model rat is shown in table 1.
TABLE 1 Effect of the Chinese medicinal composition of the present invention on the defecation amount of rats
The test results show that the defecation amount and the ink propulsion rate of the rats in the model group are obviously reduced compared with those in the normal group; compared with the model group, the defecation amount and the ink propulsion rate of rats of the Chinese medicinal composition 1-7 groups are obviously prolonged. The test results prove that the traditional Chinese medicine composition can increase the small intestine driving force of a model rat and increase the defecation amount of the model rat, and indicates that the traditional Chinese medicine composition can be used as a medicine for treating functional constipation.
The effect of the traditional Chinese medicine composition on the myoelectricity of the colon in the body of a functional constipation model rat is shown in table 2.
TABLE 2 Effect of the Chinese medicinal composition of the present invention on the myoelectric activity of rat colon in vivo
The test results show that compared with the blank control group, the colon myoelectricity slow wave frequency of the rat in the model group is reduced, and the amplitude is reduced. Compared with a model group, the rat colon electromyography slow wave frequency of the Chinese medicinal composition 1-7 groups of the invention is accelerated, and the amplitude is increased, and the Chinese medicinal composition can be also proved to be clinically used for treating habitual constipation.
Claims (3)
1. A traditional Chinese medicine composition for treating constipation is characterized by being prepared from 10 parts by weight of rheum officinale, 10 parts by weight of mirabilite, 10 parts by weight of immature bitter orange, 10 parts by weight of mangnolia officinalis, 10 parts by weight of elecampane, 10 parts by weight of areca nut, 5 parts by weight of cynanchum paniculatum and 5 parts by weight of uncaria.
2. The method for preparing the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: grinding the prescription amount of traditional Chinese medicines into fine powder respectively, mixing thoroughly, sieving with 80 mesh sieve, adding appropriate amount of vaseline, and mixing well to obtain the traditional Chinese medicine composition.
3. Use of the Chinese medicinal composition of claim 1 in the preparation of a medicament for treating functional constipation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910800943.5A CN110448629B (en) | 2019-08-28 | 2019-08-28 | Traditional Chinese medicine composition for treating constipation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910800943.5A CN110448629B (en) | 2019-08-28 | 2019-08-28 | Traditional Chinese medicine composition for treating constipation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110448629A CN110448629A (en) | 2019-11-15 |
| CN110448629B true CN110448629B (en) | 2021-06-04 |
Family
ID=68489576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910800943.5A Active CN110448629B (en) | 2019-08-28 | 2019-08-28 | Traditional Chinese medicine composition for treating constipation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110448629B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641845A (en) * | 2021-01-18 | 2021-04-13 | 广州中医药大学第一附属医院 | Traditional Chinese medicine composition for relieving distension and relaxing bowels and preparation method and application thereof |
| CN113209205A (en) * | 2021-06-18 | 2021-08-06 | 上海市第七人民医院(上海中医药大学附属第七人民医院) | Traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973693A (en) * | 2011-10-27 | 2013-03-20 | 成都中医药大学 | Pharmaceutical composition used for relaxing bowels to lose weight, and preparation method and application thereof |
| CN105232854A (en) * | 2015-11-26 | 2016-01-13 | 河南中医学院 | Traditional Chinese medicine pill treating empirical constipation |
| CN105641137A (en) * | 2014-11-11 | 2016-06-08 | 天津中敖生物科技有限公司 | Traditional Chinese medicinal decoction for treating swine constipation and preparation method of traditional Chinese medicinal decoction |
| CN107441231A (en) * | 2017-08-29 | 2017-12-08 | 成都中医药大学附属医院 | A kind of Chinese medicine composition for being used to treat constipation |
| CN108030818A (en) * | 2017-12-26 | 2018-05-15 | 许书银 | Chinese medicine composition for treating constipation and preparation method thereof |
| CN108114046A (en) * | 2018-02-10 | 2018-06-05 | 哈尔滨市固元科技发展有限公司 | A kind of Aperient suppository and preparation method thereof |
-
2019
- 2019-08-28 CN CN201910800943.5A patent/CN110448629B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973693A (en) * | 2011-10-27 | 2013-03-20 | 成都中医药大学 | Pharmaceutical composition used for relaxing bowels to lose weight, and preparation method and application thereof |
| CN105641137A (en) * | 2014-11-11 | 2016-06-08 | 天津中敖生物科技有限公司 | Traditional Chinese medicinal decoction for treating swine constipation and preparation method of traditional Chinese medicinal decoction |
| CN105232854A (en) * | 2015-11-26 | 2016-01-13 | 河南中医学院 | Traditional Chinese medicine pill treating empirical constipation |
| CN107441231A (en) * | 2017-08-29 | 2017-12-08 | 成都中医药大学附属医院 | A kind of Chinese medicine composition for being used to treat constipation |
| CN108030818A (en) * | 2017-12-26 | 2018-05-15 | 许书银 | Chinese medicine composition for treating constipation and preparation method thereof |
| CN108114046A (en) * | 2018-02-10 | 2018-06-05 | 哈尔滨市固元科技发展有限公司 | A kind of Aperient suppository and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 运脾法治疗儿童功能性便秘;陈文利等;《四川中医》;20050715;第23卷(第07期);第87-88页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110448629A (en) | 2019-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102526616B (en) | Chinese medicinal herb pills for treating cholecystitis and gallstone | |
| CN110448629B (en) | Traditional Chinese medicine composition for treating constipation | |
| CN102357198B (en) | Chinese medicinal composition for treating constipation | |
| CN112138054A (en) | Chinese herbal medicine preparation for treating hemorrhoids and preparation method thereof | |
| CN104288701A (en) | Traditional Chinese medicine composition for treating cholecystitis | |
| CN108853258B (en) | Traditional Chinese medicine composition for treating functional constipation and application thereof | |
| CN107441409A (en) | Chinese medicine composition for treating habitual constipation and preparation method thereof | |
| CN104398654A (en) | Traditional Chinese medicine healthcare product for treating constipation of middle aged and elderly people and preparation method of traditional Chinese medicine healthcare product | |
| CN100579562C (en) | Oral Chinese medicine composition for treating constipation | |
| CN102357197B (en) | Traditional Chinese medicine composition for treating constipation | |
| CN109224039B (en) | Chinese medicinal composition for treating kidney fibrosis and tonifying kidney | |
| CN103655931B (en) | Chinese medicine composition for the treatment of ureteral calculus and preparation method thereof | |
| CN114344422A (en) | Traditional Chinese medicine composition for preventing and treating postoperative constipation caused by qi and blood deficiency and intestinal dryness and application thereof | |
| CN101700390B (en) | Oral traditional Chinese medicine composition for treating fatty liver | |
| CN102430009B (en) | Traditional Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN110141619B (en) | Chinese herbal medicine composition for treating constipation and preparation method of gel patch thereof | |
| CN111249381A (en) | Application of composition in preparation of medicine for preventing and treating constipation | |
| CN104069284A (en) | Traditional Chinese medicine preparation for treating calculus | |
| CN1814131A (en) | Chinese medicine for treating astriction and preparing method | |
| CN108653572A (en) | A kind of extract oral agent that treating constipation and preparation method | |
| CN103720949A (en) | Capsule for relieving constipation and clearing bowels and preparation method thereof | |
| CN105998519A (en) | Oral medicine for treating frequent micturition due to pelvic inflammatory disease | |
| CN114146134B (en) | Traditional Chinese medicine composition with effects of warming channels and relieving pain and application thereof | |
| CN101095759B (en) | Medicine that is coated on the navel for treating constipation | |
| CN114246931B (en) | External application preparation for treating winter diseases in summer and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |