CN110448531A - A kind of preparation method of the sustained release preparation of the pellet containing brufen - Google Patents

A kind of preparation method of the sustained release preparation of the pellet containing brufen Download PDF

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Publication number
CN110448531A
CN110448531A CN201910846266.0A CN201910846266A CN110448531A CN 110448531 A CN110448531 A CN 110448531A CN 201910846266 A CN201910846266 A CN 201910846266A CN 110448531 A CN110448531 A CN 110448531A
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fixed
preparation
powder
raw material
case
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CN110448531B (en
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刘显海
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Yunpeng Pharmaceutical Group Co.,Ltd.
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Beijing Yunpeng Pengcheng Pharmaceutical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1664Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Botany (AREA)
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  • Medicinal Preparation (AREA)

Abstract

The invention belongs to field of medicine preparing technology, the preparation method of the sustained release preparation of specifically a kind of pellet containing brufen, raw material brufen powder and microcrystalline cellulose are added in batch mixer stir it is full and uniform after obtain mixed raw material;By lysate in raw material and hydroxypropyl methylcellulose jointly as being stirred in batch mixer, it is continuously added hydroxypropyl methylcellulose in whipping process, is dissolved completely in hydroxypropyl methylcellulose in lysate, obtaining can be by the class paste that spray head sprays as adhesive;Part lysate is sprayed on mixed raw material surface, and after carrying out the drying of 20-35 celsius temperature 5-10 minutes to mixed raw material, it puts into pellet processing machine, and adhesive is uniformly sprayed on by automatic nozzle by mixed raw material surface, pellet is made in centrifugation, while brufen drug effect can be improved in the present invention, sufferer constitution and immunity are improved, assists sufferer rehabilitation, and the mouthfeel of pill is adjusted in orange peel and dried lily powder, it assists old man to swallow, improves pharmacological property.

Description

A kind of preparation method of the sustained release preparation of the pellet containing brufen
Technical field
The invention belongs to field of medicine preparing technology, the preparation of the sustained release preparation of specifically a kind of pellet containing brufen Method.
Background technique
Rheumatic arthritis is a kind of common acute or chronic connective tissue inflammation.Recurrent exerbation and heart can be involved. Clinic one by joint and muscle it is migrans it is miserable, weigh, characterized by pain.Belong to allergic disease.It is the main of rheumatic fever One of performance, mostly with febris acuta and arthralgia onset.
Rheumatic arthritis is a kind of performance of rheumatic fever.Rheumatic fever is caused by the infection of A group beta hemolytic streptococcus Whole body allergic disease, onset of disease have often erysipelas etc. infect medical history.Rheumatic fever onset is anxious, and rheumatic arthritis can invade Violate heart, the performance such as causes rheumatic heart disease, and have fever, subcutaneous nodule and fash.
There are two features for rheumatic arthritis: first is that joint is red, swollen, hot, pain is obvious, stiff, site of pathological change is usually It is the lower limb large joint such as knee, hip, ankle, followed by shoulder, elbow, wrist joint, the Minor articulus of brothers is rare.Second is that pain migration is indefinite, It is the breaking-out of this joint for a period of time, is that joint discomfort for a period of time, but durante dolors are not grown, and can be disappeared within several days It moves back.Blood is chemically examined erythrocyte sedimentation rate and is accelerated, and resists " 0 " titre to increase, rheumatoid factor negative.It is seldom recurred after healing, deformity is not stayed in joint, is had Patient can leave heart disease.
The drug for treating rheumatic arthritis currently on the market has very much, such as Indometacin Enteric-coated Tablets, but these medicines are deposited It is unstable in blood concentration, frequent problem of taking medicine, and side effect is big, therapeutic effect is unobvious, while most drugs are presented Capsule, and the main patient groups of rheumatic arthritis be old man, old man is in taking micelle, the swallow of old man It is weaker, be easy to cause capsule to block larynx Nong, and capsule dissolve rear drug smell it is excessively unpleasant, be easy to cause the vomiting of sufferer, Reduce the therapeutic effect of drug.
Summary of the invention
In order to make up for the deficiencies of the prior art, solve that old man's dysphagia after capsule is made in drug, capsule dissolves rear drug Odor stimulation, cause sufferer vomiting reduce medication effect and drug concentration it is unstable, medication frequently, side effect it is big and extensive The problem of multiple time length, a kind of preparation method of the sustained release preparation of the pellet containing brufen proposed by the present invention.
The technical solution adopted by the present invention to solve the technical problems is: a kind of pellet containing brufen of the present invention The preparation method of sustained release preparation, the raw material include: 30-40 parts of brufen powder,
Ibuprofen molecule formula is as follows:
(microcrystalline cellulose, main component are for one 5-15 parts of additive, two 10-15 parts of additive, 1-3 parts of microcrystalline cellulose With β -1,4- glucoside bond combine straight chain formula polysaccharose substance), 1-3 part of hydroxypropyl methylcellulose (selection high purity cotton Cellulose is specially etherified and is made under alkaline condition as raw material), 10-15 parts of lysate;The preparation method step is such as Under:
S1: raw material brufen powder and microcrystalline cellulose are added in batch mixer after stirring 10-15 minutes and additive is added One continues to stir, and obtains mixed raw material after stirring to be mixed is full and uniform;
S2: it by lysate in raw material and hydroxypropyl methylcellulose jointly as being stirred in batch mixer 30-50 minutes, stirs It is continuously added hydroxypropyl methylcellulose in the process, is dissolved completely in hydroxypropyl methylcellulose in lysate, obtains to spray by spray head Class paste out can preferably control hypromellose as adhesive, by the way that hydroxypropyl methylcellulose is added when being stirred The bonding effect of adhesive can be improved to reach most suitable concentration in the dosage of element;
S3: part lysate is sprayed on mixed raw material surface obtained in S1, and 20-35 degrees Celsius is carried out to mixed raw material High temperature dry 5-10 minute after, put into pellet processing machine in, and pass through automatic nozzle adhesive obtained in S2 is uniformly sprayed on it is mixed Raw material surface is closed, centrifugation is made pellet, by the way that lysate is added in mixed raw material before being passed through pellet processing machine, can make inside lysate Divide nutriment to enter inside mixed raw material, improves the drug effect of mixed raw material, while adhesive can be prevented excessively sticky, influence to mix Close the bonding effect of raw material;
S4: pellet manufactured in S3 is placed in the extrusion bucket of packet sizing device, additive two is placed in the benefit of packet sizing device In feed bin, additive one is added in powder case and starting packet sizing device;
The additive one is that the smashed powder of orange peel natural drying or lily petal are dried under 25-35 degrees Celsius The dried lily powder crushed afterwards can effectively be dropped according to the mixture that the ratio of 1:3 mixes by the natural air drying of orange peel Volatile oil content in low orange peel improves flavones internalization in orange peel and closes the rising of object content, to improve the medicinal valence of orange peel Value, orange peel has promoting the circulation of qi and invigorating stomach, eliminating dampness and eliminating phlegm and other effects, and brufen can be assisted to improve treatment of the brufen to rheumatism Effect, dried lily have removing toxic substances, reason spleen stomach invigorating, dampness removing disperse accumulation, antitoxic heart-soothing and sedative, promote blood circulation and other effects, can assist cloth Lip river Sufferer toxin expelling is assisted while sweet smell treatment rheumatism, enhances sufferer constitution.
The lysate is after orange peel and lily petal are disinfected in the case where abundant drying, according to the ratio of 3:1 The filtrate that example is obtained by filtration after mixed merga pass alcoholic fermentation 10-30 days, is fermented by orange peel and dried lily, In Ethyl alcohol is generated in fermentation process, ethyl alcohol can be such that hydroxypropyl methylcellulose sufficiently dissolves and obtain adhesive, and containing more in ethyl alcohol Benefit materials in orange peel and dried lily, can be improved the resume speed of sufferer, thus beneficial to sufferer while improving drug effect Restore, while ethyl alcohol can reduce patient to the feeling ability of pain, assist patient sleeps.
Ethyl alcohol
The additive two is after orange peel and lily petal are disinfected in the case where abundant drying, according to 3:1's The filter residue that ratio is obtained by filtration after mixing merga pass alcoholic fermentation 10-30 days, filter residue are dried by 30-50 celsius temperature The powder crushed afterwards, powder are placed in the dope that intermittent addition lysate obtains in blender;Orange peel and lily Still contain a large amount of benefit materials after valve fermentation in it, while after everfermentation and drying dual operation, can significantly kill citrus The virus and bacterium that skin and lily petal include are reinforcing patient after taking and then while assisting sufferer treatment and recovery Matter.
Packet sizing device used in S4 step includes fixed case, squeezes out bucket and controller;The extrusion bucket passes through fixation Bar is fixed at the top of fixed case;The right end upper surface for squeezing out bucket is fixed with fixed plate;The fixed plate upper surface is fixed with Motor, motor are electrically connected with the controller;The drive shaft of the motor is arranged across fixed plate, and is fixed with spiral shell in squeezing out in bucket Bar;The extrusion bucket bottom offers extrusion cavities;The extrusion cavities side wall cambered surface design;Cavity is offered in the fixed plate; The shaft of the motor is connected to first gear in the part of the surface fixing sleeve in cavity;The second tooth is rotatably connected in the cavity Wheel;The second gear is engaged with first gear;The second gear lower surface is fixed with transmission shaft;Prolong the transmission shaft lower end It extends to and squeezes out bucket bottom, and transmission shaft surface fixing sleeve is connected to the cutter being evenly arranged, and the upper surface of cutter is close to crowded Bucket bottom is designed out;Partition, and partition inclined design are fixed in the fixed case;Space in fixed case is divided by the partition Feed supplement storehouse and discharging bin two parts;Above the feed supplement position in storehouse partition;At the top of the fixed case it is corresponding with extrusion cavities offer into Material mouth;The fixed case inner left wall is fixedly connected with electric telescopic rod by fixing seat, and electric telescopic rod is electrically connected with controller It connects;The driving end of the electric telescopic rod is rotatably connected to idler wheel, and original state bottom roller part is immersed in additive two;Institute It states roller surface and is enclosed with water suction cotton layer;The electric telescopic rod is located in feed supplement storehouse, and with partition Parallel Design;It is described solid Determine to offer feed opening on the left of case, feed opening is located above electric telescopic rod;The baffle surface offers and gating location Corresponding packet starches mouth;Slide plate is fixed in the fixed case;The slide plate inclined design, and close to packet slurry mouth design at inclination; Outer wall is fixed with discharge port on the left of the fixed case, and slide plate left end extends to discharge port design;When work, when pellet is placed in packet slurry It is placed in the feed supplement storehouse of packet sizing device in the extrusion bucket of device, by additive two, in the addition to powder case of additive one, passes through control Device control electric motor starting processed, pellet squeeze mixing to squeeze by motor rotation drive screw rod rotation by screw rod forms bolus, It is squeezed out simultaneously by extrusion cavities, cutter rotation is driven by first gear and second gear engagement in motor rotation process, is made Cutter intermittence cuts the bolus that extrusion cavities squeeze out, and the bolus after cutting is fallen in fixed case and worn by feed inlet It crosses packet and starches mouth, in bolus before packet slurry mouth, controller controls one group of electric telescopic rod completion and stretches, and stretches out in electric telescopic rod Idler wheel rotates in the process, starches mouth by packet, makes additive two in packet slurry degree of lip-rounding film forming by the absorbent cotton layer of roller surface, in medicine When group is by packet slurry mouth, the film that additive two is formed is wrapped in bolus surface, and orange peel powder and lily in bolus can be improved The content of valve powder, to improve bolus pharmacological property while reducing the bitter taste of bolus, bolus falls to cunning after packet starches mouth Plate surface rolls in sled surface, bolus can be made to form more regular pill during scrolling, improves pill face value, make Pill is more mellow and fuller.
The fixed case outer right wall is fixed with connecting plate;The connecting plate upper surface is fixed with air blower, air blower with Controller electrical connection;Powder case is equipped at the air outlet of the air blower;The powder case is fixed on fixed case outer right wall, and Powder case is connected to the gap between partition and slide plate, while the air outlet of powder case connection air blower, and powder box top is opened Equipped with opening, opening is equipped with sealing-plug;When work, when electric telescopic rod is stretched out, controller controls air blower starting, air blower The additive one in powder case is driven to be blown to sled surface, bolus surface adhesion additive one in sled surface rolling process, To improve the content of orange peel and dried lily powder in bolus, so that reaching maximized improves pill drug effect, while citrus Skin and lily petal powder are adhered to bolus surface, bolus can be prevented to be adhered to sled surface, and medicament contg in bolus is caused to drop Low situation, while sled surface is polluted, it causes bolus that can not form more regular pill after sled surface, influences Pill shape.
The slide plate upper surface offers slideway;The slideway starches mouth corresponding position elliptic design in packet, and described Slideway curved design from right to left;When work, when pill falls to sled surface, rolls, lead into slideway, and through slideway The curved design of slideway is crossed, the multi-direction rolling of bolus can be made, to make pill surface uniform adhesion additive one, can be improved simultaneously Pill mellow and full degree after molding.
The slide plate upper surface offers flowing groove;The flowing groove is connected to slideway upper end, and flowing groove is wide from right to left Degree successively increases;When work, additive one is set uniformly to be blown into ramp surface in blower work, to improve pill surface additive One uniformity, while wind speed can be reduced by the change width of flowing groove, so that influence of the air blower to additive one is reduced, Prevent additive one from raising.
Beneficial effects of the present invention are as follows:
1. a kind of preparation method of the sustained release preparation of pellet containing brufen of the present invention passes through additive one and addition The addition of agent two while brufen drug effect can be improved, improves sufferer constitution and immunity, assists sufferer rehabilitation, and orange peel The mouthfeel of pill is adjusted with dried lily powder, old man is assisted to swallow, improves pharmacological property.
2. the preparation method of the sustained release preparation of a kind of pellet containing brufen of the present invention, by the way that electric expansion is arranged Bar, idler wheel and packet slurry mouth make to wrap slurry automatically by the bolus of packet slurry mouth, while using manpower and material resources sparingly, improve drug mouthfeel, from And sufferer is reduced to the conflict psychology of drug.
Detailed description of the invention
The present invention will be further explained below with reference to the attached drawings.
Fig. 1 is flow chart of the method for the present invention;
Fig. 2 is the cross-sectional view of packet sizing device used in the present invention;
Fig. 3 is the perspective view of Fig. 2 middle slide plate;
In figure: fixed case 1, feed supplement storehouse 12, discharging bin 13, feed inlet 14, electric telescopic rod 15, idler wheel 16, is inhaled partition 11 Water cotton layer 17, packet slurry mouth 18, slide plate 19, slideway 191, flowing groove 192, squeeze out bucket 2, screw rod 21, extrusion cavities 22, fixed plate 3, Cavity 31, second gear 32, first gear 33, transmission shaft 34, cutter 35, connecting plate 4, air blower 41, powder case 42.
Specific embodiment
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below Specific embodiment is closed, the present invention is further explained.
As shown in Figure 1 to Figure 3, the preparation method of the sustained release preparation of a kind of pellet containing brufen of the present invention, this hair A kind of preparation method of the sustained release preparation of bright pellet containing brufen, the raw material include: 30-40 parts of brufen powder, Ibuprofen molecule formula is as follows:
(microcrystalline cellulose, main component are for one 5-15 parts of additive, two 10-15 parts of additive, 1-3 parts of microcrystalline cellulose With β -1,4- glucoside bond combine straight chain formula polysaccharose substance), 1-3 part of hydroxypropyl methylcellulose (selection high purity cotton Cellulose is specially etherified and is made under alkaline condition as raw material), 10-15 parts of lysate;The preparation method step is such as Under:
S1: raw material brufen powder and microcrystalline cellulose are added in batch mixer after stirring 10-15 minutes and additive is added One continues to stir, and obtains mixed raw material after stirring to be mixed is full and uniform;
S2: it by lysate in raw material and hydroxypropyl methylcellulose jointly as being stirred in batch mixer 30-50 minutes, stirs It is continuously added hydroxypropyl methylcellulose in the process, is dissolved completely in hydroxypropyl methylcellulose in lysate, obtains to spray by spray head Class paste out can preferably control hypromellose as adhesive, by the way that hydroxypropyl methylcellulose is added when being stirred The bonding effect of adhesive can be improved to reach most suitable concentration in the dosage of element;
S3: part lysate is sprayed on mixed raw material surface obtained in S1, and 20-35 degrees Celsius is carried out to mixed raw material High temperature dry 5-10 minute after, put into pellet processing machine in, and pass through automatic nozzle adhesive obtained in S2 is uniformly sprayed on it is mixed Raw material surface is closed, centrifugation is made pellet, by the way that lysate is added in mixed raw material before being passed through pellet processing machine, can make inside lysate Divide nutriment to enter inside mixed raw material, improves the drug effect of mixed raw material, while adhesive can be prevented excessively sticky, influence to mix Close the bonding effect of raw material;
S4: pellet manufactured in S3 is placed in the extrusion bucket 2 of packet sizing device, additive two is placed in the benefit of packet sizing device In feed bin 12, additive one is added in powder case 42 and starting packet sizing device;
The additive one is that the smashed powder of orange peel natural drying and lily petal are dried under 25-35 degrees Celsius The mixture that the dried lily powder crushed afterwards obtains after mixing according to 1:3 ratio can have by the natural air drying of orange peel Effect reduces volatile oil content in orange peel, improves flavones internalization conjunction object content in orange peel and rises, to improve the medicine of orange peel With value, orange peel has promoting the circulation of qi and invigorating stomach, eliminating dampness and eliminating phlegm and other effects, and brufen can be assisted to improve brufen to rheumatism Therapeutic effect, dried lily have removing toxic substances, reason spleen stomach invigorating, dampness removing disperse accumulation, antitoxic heart-soothing and sedative, promote blood circulation and other effects, can assist Sufferer toxin expelling is assisted while ibuprofen rheumatism, enhances sufferer constitution.
The lysate is after orange peel and lily petal are disinfected in the case where abundant drying, according to the ratio of 3:1 The filtrate that example is obtained by filtration after mixed merga pass alcoholic fermentation 10-30 days, is fermented by orange peel and dried lily, In Ethyl alcohol is generated in fermentation process, ethyl alcohol can be such that hydroxypropyl methylcellulose sufficiently dissolves and obtain adhesive, and containing more in ethyl alcohol Benefit materials in orange peel and dried lily, can be improved the resume speed of sufferer, thus beneficial to sufferer while improving drug effect Restore, while ethyl alcohol can reduce patient to the feeling ability of pain, assist patient sleeps.
Ethyl alcohol
The additive two is after orange peel and lily petal are disinfected in the case where abundant drying, according to 3:1's The filter residue that ratio is obtained by filtration after mixing merga pass alcoholic fermentation 10-30 days, filter residue are dried by 30-50 celsius temperature The powder crushed afterwards, powder are placed in the dope that intermittent addition lysate obtains in blender;Orange peel and lily Still contain a large amount of benefit materials after valve fermentation in it, while after everfermentation and drying dual operation, can significantly kill citrus The virus and bacterium that skin and lily petal include are reinforcing patient after taking and then while assisting sufferer treatment and recovery Matter.
Packet sizing device used in S4 step includes fixed case 1, squeezes out bucket 2 and controller;The extrusion bucket 2 passes through solid Fixed pole is fixed on 1 top of fixed case;The right end upper surface for squeezing out bucket 2 is fixed with fixed plate 3;3 upper surface of fixed plate It is fixed with motor, motor is electrically connected with the controller;The drive shaft of the motor is arranged across fixed plate 3, and solid in bucket 2 in squeezing out It is connected with screw rod 21;2 bottom of extrusion bucket offers extrusion cavities 22;22 side wall cambered surface of the extrusion cavities design;The fixed plate 3 Inside offer cavity 31;The shaft of the motor is connected to first gear 33 in the part of the surface fixing sleeve in cavity 31;The sky Second gear 32 is rotatably connected in chamber 31;The second gear 32 is engaged with first gear 33;32 following table of second gear Face is fixed with transmission shaft 34;34 lower end of transmission shaft, which extends to, squeezes out 2 bottom of bucket, and 34 surface fixing sleeve of transmission shaft is connected to The cutter 35 of even arrangement, and the upper surface of cutter 35 is designed close to 2 bottom of bucket is squeezed out;Be fixed in the fixed case 1 every Plate 11, and 11 inclined design of partition;Space in fixed case 1 is divided into 13 two parts of feed supplement storehouse 12 and discharging bin by the partition 11; 12 partitions of the feed supplement storehouse, 11 top;1 top of fixed case is corresponding with extrusion cavities 22 to offer feed inlet 14;The fixation 1 inner left wall of case is fixedly connected with electric telescopic rod 15 by fixing seat, and electric telescopic rod 15 is electrically connected with the controller;The electricity The driving end of dynamic telescopic rod 15 is rotatably connected to idler wheel 16, and 16 part of original state bottom roller is immersed in additive two;It is described Idler wheel 16 is coated with water suction cotton layer 17;The electric telescopic rod 15 is located in feed supplement storehouse 12, and parallel with partition 11 sets Meter;Feed opening is offered on the left of the fixed case 1, feed opening is located at 15 top of electric telescopic rod;11 surface of partition opens up There is packet slurry mouth 18 corresponding with 14 position of feed inlet;Slide plate 19 is fixed in the fixed case 1;19 inclined design of slide plate, And it is designed at inclination close to packet slurry mouth 18;The 1 left side outer wall of fixed case is fixed with discharge port, and 19 left end of slide plate extends to discharging Mouth design;When work, when the feed supplement storehouse 12 for being placed in packet sizing device in the extrusion bucket 2 that pellet is placed in packet sizing device, by additive two Interior, additive one is added to powder case 42, controls electric motor starting by controller, motor rotation drives the rotation of screw rod 21 to pass through Pellet squeeze mixing to squeeze by screw rod 21 forms bolus, while being squeezed out by extrusion cavities 22, passes through in motor rotation process First gear 33 and the engagement of second gear 32 drive cutter 35 to rotate, and make the intermittent medicine for squeezing out extrusion cavities 22 of cutter 35 Group is cut, and the bolus after cutting falls in fixed case 1 by feed inlet 14 and pass through packet slurry mouth 18, passes through packet slurry in bolus Before mouth 18, controller controls electric telescopic rod 15 and completes one group of flexible, rotation of idler wheel 16 during electric telescopic rod 15 is stretched out, Mouth 18 is starched by packet, so that additive two is formed film in packet slurry mouth 18 by the absorbent cotton layer on 16 surface of idler wheel, in bolus by wrapping When starching mouth 18, the film that additive two is formed is wrapped in bolus surface, can be improved in bolus, orange peel powder and lily petal powder Content, thus while reducing the bitter taste of bolus improve bolus pharmacological property, bolus by packet starch mouth 18 after fall to slide plate 19 Surface can make bolus form more regular pill during scrolling in 19 surface scrolls of slide plate, improve pill face value, make Pill is more mellow and fuller.
1 outer right wall of fixed case is fixed with connecting plate 4;4 upper surface of connecting plate is fixed with air blower 41, air blast Machine 41 is electrically connected with the controller;Powder case 42 is equipped at the air outlet of the air blower 41;The powder case 42 is fixed on fixation 1 outer right wall of case, and powder case 42 is connected to the gap between partition 11 and slide plate 19, while powder case 42 is connected to air blower 41 Air outlet, and opening is offered at the top of powder case 42, opening is equipped with sealing-plug;When work, when electric telescopic rod 15 is stretched out, Controller controls air blower 41 and starts, and air blower 41 drives the additive one in powder case 42 to be blown to 19 surface of slide plate, and bolus exists Surface adhesion additive one during 19 surface scrolls of slide plate, so that the content of orange peel and dried lily powder in bolus is improved, Pill drug effect is improved to reach maximized, while orange peel and lily petal powder are adhered to bolus surface, can prevent medicine The case where group is adhered to 19 surface of slide plate, and medicament contg is caused in bolus to reduce, while polluting 19 surface of slide plate, cause bolus without Method is forming more regular pill behind 19 surface of slide plate, influences pill shape.
19 upper surface of slide plate offers slideway 191;The slideway 191 is set in packet slurry 18 corresponding position ellipse of mouth Meter, and the curved design from right to left of the slideway 191;When work, when pill falls to 19 surface of slide plate, into slideway 191, And rolled by slideway 191, by the curved design of slideway 191, the multi-direction rolling of bolus can be made, to keep pill surface uniform Adhesive additive one, while pill mellow and full degree after molding can be improved.
19 upper surface of slide plate offers flowing groove 192;The flowing groove 192 is connected to 191 upper end of slideway, and flowing groove 192 from right to left width successively increase;When work, additive one is set uniformly to be blown into 191 surface of slideway in blower work, to mention The uniformity of high pill surface additive one, while wind speed can be reduced by the change width of flowing groove 192, to reduce air blast Influence of the machine 41 to additive one, prevents additive one from raising.
When work, it is added and adds after being stirred 10-15 minutes in raw material brufen powder and microcrystalline cellulose addition batch mixer Add agent one to continue to stir, obtains mixed raw material after stirring to be mixed is full and uniform;By lysate in raw material and hydroxypropyl methylcellulose Jointly as being stirred in batch mixer 30-50 minutes, it is continuously added hydroxypropyl methylcellulose in whipping process, makes hypromellose Element is dissolved completely in lysate, and obtaining can be by the class paste that spray head sprays as adhesive;The mixed raw material that will be obtained Surface spray part lysate, and to mixed raw material carry out 20-35 celsius temperature dry 5-10 minute after, investment pellet processing machine It is interior, and adhesive is uniformly sprayed on by automatic nozzle by mixed raw material surface, pellet is made in centrifugation;Pellet is placed in packet slurry dress It is placed in the feed supplement storehouse 12 of packet sizing device, in the addition to powder case 42 of additive one, leads in the extrusion bucket 2 set, by additive two Controller control electric motor starting is crossed, motor rotation drives the rotation of screw rod 21 that pellet is carried out extruding mixing by screw rod 21 and squeezes shape It squeezes out at bolus, while by extrusion cavities 22, is driven in motor rotation process by first gear 33 and the engagement of second gear 32 Cutter 35 rotate, and make cutter 35 are intermittent to cut the bolus that extrusion cavities 22 squeeze out, the bolus after cutting by into Material mouth 14 falls in fixed case 1 and passes through packet slurry mouth 18, and before bolus passes through packet slurry mouth 18, controller controls electric telescopic rod 15 It completes one group of flexible, rotation of idler wheel 16 during electric telescopic rod 15 is stretched out and passes through 16 surface of idler wheel by packet slurry mouth 18 Absorbent cotton layer makes additive two in the packet slurry formation film of mouth 18, and when bolus is by packet slurry mouth 18, the film that additive two is formed is wrapped up In bolus surface, bolus falls to 19 surface of slide plate after packet starches mouth 18, in 19 surface scrolls of slide plate, bolus can be made to roll Pill is formed in the process, and when electric telescopic rod 15 is stretched out, controller controls air blower 41 and starts, and air blower 41 drives powder case Additive one in 42 is blown to 19 surface of slide plate, bolus surface adhesion additive one, pill during 19 surface scrolls of slide plate When falling to 19 surface of slide plate, roll into slideway 191, and through slideway 191 to discharge port.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should Understand, the present invention is not limited to the above embodiments, and the above embodiments and description only describe originals of the invention Reason, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes and improvements It all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent circle It is fixed.

Claims (8)

1. a kind of preparation method of the sustained release preparation of pellet containing brufen, it is characterised in that: the raw material includes: brufen powder 30-40 parts, one 5-15 parts of additive, two 10-15 parts of additive, 1-3 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose, dissolution 10-15 parts of liquid;Steps are as follows for the preparation method:
S1: raw material brufen powder and microcrystalline cellulose are added in batch mixer after stir 10-15 minutes addition additive one after Continuous stirring obtains mixed raw material after stirring to be mixed is full and uniform;
S2: by lysate in raw material and hydroxypropyl methylcellulose jointly as being stirred 30-50 minutes in batch mixer, whipping process In be continuously added hydroxypropyl methylcellulose, be dissolved completely in hydroxypropyl methylcellulose in lysate, obtain can by spray head spray Class paste is as adhesive;
S3: part lysate is sprayed on mixed raw material surface obtained in S1, and 20-35 celsius temperature is carried out to mixed raw material It after drying 5-10 minutes, puts into pellet processing machine, and adhesive obtained in S2 is uniformly sprayed on to mixing original by automatic nozzle Expect surface, pellet is made in centrifugation;
S4: pellet manufactured in S3 is placed in the extrusion bucket (2) of packet sizing device, additive two is placed in the feed supplement of packet sizing device In storehouse (12), the addition of additive one is interior to powder case (42) and starts packet sizing device.
2. a kind of preparation method of the sustained release preparation of pellet containing brufen according to claim 1, it is characterised in that: described Additive one is that crushing obtains after the smashed powder of orange peel natural drying and lily petal drys under 25-35 degrees Celsius The mixture that dried lily powder is mixed according to the ratio of 1:3.
3. a kind of preparation method of the sustained release preparation of pellet containing brufen according to claim 1, it is characterised in that: described Lysate is that orange peel and lily petal after disinfection treatment, mix merga pass according to the ratio of 3:1 in the case where abundant drying The filtrate being obtained by filtration after alcoholic fermentation 10-30 days.
4. a kind of preparation method of the sustained release preparation of pellet containing brufen according to claim 3, it is characterised in that: described Additive two is that orange peel and lily petal after disinfection treatment, mix and lead to according to the ratio of 3:1 in the case where abundant drying The filter residue being obtained by filtration after crossing alcoholic fermentation 10-30 days, crushing obtains after filter residue is dried by 30-50 celsius temperature Powder, powder are placed in the dope that intermittent addition lysate obtains in blender.
5. a kind of preparation method of the sustained release preparation of pellet containing brufen according to claim 1, it is characterised in that: S4 step Packet sizing device used in rapid includes fixed case (1), squeezes out bucket (2) and controller;The extrusion bucket (2) is solid by fixed link It is connected at the top of fixed case (1);The right end upper surface for squeezing out bucket (2) is fixed with fixed plate (3);Table on the fixed plate (3) Face is fixed with motor, and motor is electrically connected with the controller;The drive shaft of the motor is arranged across fixed plate (3), and in extrusion bucket (2) screw rod (21) are fixed in;Extrusion bucket (2) bottom offers extrusion cavities (22);Extrusion cavities (22) the side wall cambered surface Design;Cavity (31) are offered in the fixed plate (3);The shaft of the motor is in the part of the surface fixing sleeve in cavity (31) It is connected to first gear (33);Second gear (32) are rotatably connected in the cavity (31);The second gear (32) and first Gear (33) engagement;Second gear (32) lower surface is fixed with transmission shaft (34);Transmission shaft (34) lower end extends to Bucket (2) bottom is squeezed out, and transmission shaft (34) surface fixing sleeve is connected to the cutter (35) being evenly arranged, and cutter (35) is upper It is designed close to bucket (2) bottom is squeezed out on surface;It is fixed with partition (11) in the fixed case (1), and partition (11) inclined design;Institute It states partition (11) and fixed case (1) interior space is divided into feed supplement storehouse (12) and discharging bin (13) two parts;Feed supplement storehouse (12) position Above partition (11);It is corresponding with extrusion cavities (22) at the top of the fixed case (1) to offer feed inlet (14);The fixed case (1) Inner left wall is fixedly connected with electric telescopic rod (15) by fixing seat, and electric telescopic rod (15) is electrically connected with the controller;It is described The driving end of electric telescopic rod (15) is rotatably connected to idler wheel (16), and original state bottom roller (16) is partially immersed in additive two It is interior;The idler wheel (16) is coated with water suction cotton layer (17);The electric telescopic rod (15) is located in feed supplement storehouse (12), and With partition (11) Parallel Design;Feed opening is offered on the left of the fixed case (1), feed opening is located on electric telescopic rod (15) Side;Partition (11) surface offers packet slurry mouth (18) corresponding with feed inlet (14) position;It is connected in the fixed case (1) There are slide plate (19);Slide plate (19) inclined design, and close to packet slurry mouth (18) design at inclination;On the left of the fixed case (1) Outer wall is fixed with discharge port, and slide plate (19) left end extends to discharge port design.
6. a kind of preparation method of the sustained release preparation of pellet containing brufen according to claim 5, it is characterised in that: described Fixed case (1) outer right wall is fixed with connecting plate (4);Connecting plate (4) upper surface is fixed with air blower (41), air blower (41) it is electrically connected with the controller;Powder case (42) are equipped at the air outlet of the air blower (41);The powder case (42) is connected In fixed case (1) outer right wall, and powder case (42) is connected to the gap between partition (11) and slide plate (19), while powder case (42) it is connected to the air outlet of air blower (41), and offers opening at the top of powder case (42), opening is equipped with sealing-plug.
7. a kind of preparation method of the sustained release preparation of pellet containing brufen according to claim 6, it is characterised in that: described Slide plate (19) upper surface offers slideway (191);The slideway (191) starches mouth (18) corresponding position elliptic design in packet, And the slideway (191) curved design from right to left.
8. a kind of preparation method of the sustained release preparation of pellet containing brufen according to claim 7, it is characterised in that: described Slide plate (19) upper surface offers flowing groove (192);The flowing groove (192) is connected to slideway (191) upper end, and flowing groove (192) width successively increases from right to left.
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