CN110448531B - Preparation method of sustained-release preparation containing ibuprofen pellets - Google Patents
Preparation method of sustained-release preparation containing ibuprofen pellets Download PDFInfo
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- CN110448531B CN110448531B CN201910846266.0A CN201910846266A CN110448531B CN 110448531 B CN110448531 B CN 110448531B CN 201910846266 A CN201910846266 A CN 201910846266A CN 110448531 B CN110448531 B CN 110448531B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The invention belongs to the technical field of medicine preparation, in particular to a preparation method of a sustained-release preparation containing ibuprofen pellets, which comprises the steps of adding raw materials of ibuprofen powder and microcrystalline cellulose into a mixer, and stirring the mixture fully and uniformly to obtain mixed raw materials; putting the solution and hydroxypropyl methylcellulose in the raw materials into a mixer together, stirring, and continuously adding the hydroxypropyl methylcellulose in the stirring process to completely dissolve the hydroxypropyl methylcellulose into the solution to obtain a paste-like substance which can be sprayed out by a spray head and is used as an adhesive; spraying partial solution on the surface of the mixed raw material, drying the mixed raw material at the high temperature of 20-35 ℃ for 5-10 minutes, putting the mixed raw material into a pill making machine, uniformly spraying an adhesive on the surface of the mixed raw material through an automatic spray head, and centrifuging to prepare a pellet.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method of a sustained-release preparation containing ibuprofen pellets.
Background
Rheumatoid arthritis is a common acute or chronic inflammation of the connective tissue. Can repeatedly attack and involve the heart. The first clinical aspect is characterized by aching, burning and pain of joints and muscles. Belongs to allergic diseases. It is one of the main manifestations of wind-damp-heat, usually manifested as acute fever and arthralgia.
Rheumatic arthritis is a manifestation of rheumatic fever. Rheumatic fever is a systemic allergic disease caused by group A beta hemolytic streptococcus infection, and the disease has a history of infection such as erysipelas at the beginning. The rheumatic fever is acute, and the rheumatic arthritis can invade the heart to cause rheumatic heart disease and has the symptoms of fever, subcutaneous nodules, rash and the like.
Rheumatic arthritis has two characteristics: firstly, the joints are red, swollen, hot and painful, and cannot move, the diseased parts are the large joints of the lower limbs such as knee, hip and ankle, and the joints of the shoulder, elbow and wrist, and the small joints of the hands and feet are rare. Secondly, the pain wanders away indefinitely, with the joint attacking for some time and the joint discomfort for some time, but the pain does not last long enough to resolve for a few days. Blood sedimentation is accelerated in blood test, the anti-0 titer is increased, and rheumatoid factor is negative. After the disease is cured, the disease rarely recurs, the joints do not have deformity, and some patients can have heart disease.
At present, a lot of drugs for treating rheumatic arthritis exist in the market, such as indometacin enteric-coated tablets and the like, but the drugs have the problems of unstable blood concentration and frequent administration, and have large side effects and unobvious treatment effect.
Disclosure of Invention
In order to make up for the defects of the prior art and solve the problems that after the medicine is prepared into capsules, the old people swallow the medicine difficultly, the smell of the medicine after the capsules are dissolved is stimulated, the vomiting of patients is caused, the medicine treatment effect is reduced, the medicine concentration is unstable, the medicine taking is frequent, the side effect is great and the recovery time is long, the invention provides the preparation method of the sustained-release preparation containing the ibuprofen pellets.
The technical scheme adopted by the invention for solving the technical problems is as follows: the invention relates to a preparation method of a sustained-release preparation containing ibuprofen pellets, which comprises the following raw materials: 30-40 parts of ibuprofen powder,
The molecular formula of ibuprofen is as follows:
5-15 parts of additive I, 10-15 parts of additive II, 1-3 parts of microcrystalline cellulose (the main component of the microcrystalline cellulose is a linear chain polysaccharide substance combined by beta-1, 4-glucoside bonds), 1-3 parts of hydroxypropyl methylcellulose (prepared by selecting high-purity cotton cellulose as a raw material and carrying out special etherification under an alkaline condition), and 10-15 parts of a dissolving solution; the preparation method comprises the following steps:
s1: adding the ibuprofen powder and the microcrystalline cellulose into a mixer, stirring for 10-15 minutes, adding the additive, continuously stirring, and mixing and stirring uniformly to obtain a mixed raw material;
s2: the dissolving solution and the hydroxypropyl methylcellulose in the raw materials are jointly placed in a mixer to be stirred for 30-50 minutes, the hydroxypropyl methylcellulose is continuously added in the stirring process, so that the hydroxypropyl methylcellulose is completely dissolved in the dissolving solution, a paste-like substance which can be sprayed out by a spray head is obtained to be used as an adhesive, and the dosage of the hydroxypropyl methylcellulose can be better controlled by adding the hydroxypropyl methylcellulose while stirring and mixing so as to reach the most suitable concentration and improve the bonding effect of the adhesive;
s3: spraying partial solution on the surface of the mixed raw material obtained in the step S1, drying the mixed raw material at the high temperature of 20-35 ℃ for 5-10 minutes, putting the dried mixed raw material into a pill making machine, uniformly spraying the adhesive obtained in the step S2 on the surface of the mixed raw material through an automatic spray head, centrifuging the mixture to prepare pellets, adding the solution into the mixed raw material before introducing the mixed raw material into the pill making machine, so that partial nutrient substances in the solution can enter the mixed raw material, the drug effect of the mixed raw material is improved, and meanwhile, the adhesive can be prevented from being too sticky and affecting the adhesive effect of the mixed raw material;
s4: placing the pellets prepared in the step S3 in an extrusion barrel of a slurry packaging device, placing an additive II in a material supplementing bin of the slurry packaging device, adding the additive I into a powder box, and starting the slurry packaging device;
the additive I is a mixture of powder obtained by naturally drying and crushing orange peels or dried lily powder obtained by drying and crushing lily petals at 25-35 ℃ and mixing the powder according to the proportion of 1:3, the volatile oil content in the orange peels can be effectively reduced and the content of flavonoid compounds in the orange peels can be increased through natural air drying of the orange peels, so that the medicinal value of the orange peels is improved, the orange peels have the effects of promoting qi circulation, invigorating stomach, eliminating dampness and phlegm and the like, and can assist ibuprofen to improve the treatment effect of the ibuprofen on rheumatic diseases, the dried lily has the effects of detoxifying, regulating spleen, invigorating stomach, promoting diuresis, removing food retention, calming the heart, soothing the nerves, promoting blood circulation and the like, and can assist the ibuprofen to treat rheumatism and assist patients to expel toxin and enhance the physique of patients.
The dissolving solution is a filtrate obtained by mixing orange peel and lily petals according to a ratio of 3:1 after the orange peel and the lily petals are sterilized under the condition of full drying, and filtering after fermenting for 10-30 days by alcohol, the orange peel and the dried lily are fermented, ethanol is generated in the fermentation process, the hydroxypropyl methylcellulose can be fully dissolved by the ethanol to obtain an adhesive, and the ethanol contains more beneficial substances in the orange peel and the dried lily, so that the recovery speed of patients can be improved, the drug effect is improved, the recovery of the patients is benefited, and the pain feeling of the patients can be reduced by the ethanol, so that the sleep of the patients is assisted.
Ethanol
The second additive is a sticky substance obtained by mixing orange peel and lily petals according to the proportion of 3:1 after being sterilized under the condition of fully drying, fermenting for 10-30 days by alcohol, filtering to obtain filter residue, drying the filter residue at the high temperature of 30-50 ℃, crushing to obtain powder, and intermittently adding a dissolving solution into the powder in a stirrer; the citrus peel and lily petals still contain a large amount of beneficial substances after fermentation, and viruses and bacteria contained in the citrus peel and lily petals can be greatly killed after double operations of fermentation and drying, so that the treatment and recovery of patients are assisted after the citrus peel and lily petals are taken, and the physique of the patients is enhanced.
The pulp wrapping device used in the step S4 comprises a fixed box, an extrusion barrel and a controller; the extrusion barrel is fixedly connected to the top of the fixed box through a fixed rod; the upper surface of the right end of the extrusion barrel is fixedly connected with a fixed plate; the upper surface of the fixed plate is fixedly connected with a motor, and the motor is electrically connected with a controller; a driving shaft of the motor penetrates through the fixing plate and is fixedly connected with a screw rod in the extrusion barrel; the bottom of the extrusion barrel is provided with an extrusion hole; the arc surface of the side wall of the extrusion hole is designed; a cavity is formed in the fixing plate; a first gear is fixedly sleeved on the surface of the rotating shaft of the motor in the cavity; a second gear is rotationally connected in the cavity; the second gear is meshed with the first gear; the lower surface of the second gear is fixedly connected with a transmission shaft; the lower end of the transmission shaft extends to the bottom of the extrusion barrel, uniformly distributed cutting knives are fixedly sleeved on the surface of the transmission shaft, and the upper surfaces of the cutting knives are designed to be close to the bottom of the extrusion barrel; the fixed box is internally and fixedly connected with a partition plate which is designed in an inclined manner; the space in the fixed box is divided into a material supplementing bin and a material discharging bin by the partition board; the material supplementing bin is arranged above the clapboard; the top of the fixed box is provided with a feed inlet corresponding to the extrusion hole; the inner wall of the left side of the fixed box is fixedly connected with an electric telescopic rod through a fixed seat, and the electric telescopic rod is electrically connected with the controller; the driving end of the electric telescopic rod is rotatably connected with a roller, and the roller is partially soaked in the additive II in an initial state; the surface of the roller is wrapped with a water-absorbing cotton cloth layer; the electric telescopic rod is positioned in the material supplementing bin and is designed in parallel with the partition plate; the left side of the fixed box is provided with a feed inlet, and the feed inlet is positioned above the electric telescopic rod; the surface of the clapboard is provided with a pulp wrapping port corresponding to the position of the feed inlet; a sliding plate is fixedly connected in the fixed box; the sliding plate is designed to be inclined, and the inclined part is designed to be close to the pulp wrapping port; the outer wall of the left side of the fixed box is fixedly connected with a discharge port, and the left end of the sliding plate extends to the discharge port; when the device works, when a pellet is placed in an extrusion barrel of a slurry wrapping device, an additive II is placed in a material supplementing bin of the slurry wrapping device, the additive I is added into a powder box, a motor is controlled by a controller to be started, the motor rotates to drive a screw to rotate, the pellet is extruded, mixed and extruded through a screw to form a drug cluster, meanwhile, the drug cluster is extruded through an extrusion hole, a cutting knife is driven to rotate through the meshing of a first gear and a second gear in the rotating process of the motor, the cutting knife intermittently cuts the drug cluster extruded from the extrusion hole, the cut drug cluster falls into a fixed box through a feed inlet and passes through the slurry wrapping port, the controller controls an electric telescopic rod to complete a group of stretching before the drug cluster passes through the slurry wrapping port, the roller rotates in the extending process of the electric telescopic rod, the additive II is positioned at the slurry wrapping port through a water absorption cotton layer on the surface of the roller, when the drug cluster passes through the slurry wrapping port, a film formed by, the content of citrus peel powder and lily petal powder in the medicinal mass can be improved, so that the bitter taste of the medicinal mass is reduced, the medicinal property of the medicinal mass is improved, the medicinal mass drops to the surface of the sliding plate after the pulp coating port and rolls on the surface of the sliding plate, and the medicinal mass can form more regular pills in the rolling process, so that the color value of the pills is improved, and the pills are more mellow and smooth.
The outer wall of the right side of the fixed box is fixedly connected with a connecting plate; the upper surface of the connecting plate is fixedly connected with a blower, and the blower is electrically connected with a controller; a powder box is arranged at the air outlet of the air blower; the powder box is fixedly connected to the outer wall of the right side of the fixed box, communicated to a gap between the partition plate and the sliding plate and communicated with an air outlet of the air blower, an opening is formed in the top of the powder box, and a sealing plug is arranged in the opening; the during operation, when electric telescopic handle stretches out, controller control air-blower starts, the air-blower drives additive in the powder case and blows to the slide surface once, the pellet rolls surface adhesion additive one at the slide surface, thereby improve the content of citrus peel and dry lily powder in the pellet, thereby reach the improvement pellet drug effect of maximize, citrus peel and lily petal powder adhesion are on the pellet surface simultaneously, can prevent the pellet adhesion on the slide surface, cause the condition of medicine content reduction in the pellet, pollute the slide surface simultaneously, cause the pellet can't form comparatively regular pellet after the slide surface, influence the pellet shape.
The upper surface of the sliding plate is provided with a slideway; the slideway is designed in an oval shape at the position corresponding to the pulp wrapping port, and is designed in a bending way from right to left; during operation, when pills fall to the surface of the sliding plate, the pills enter the slide way and roll through the slide way, and the pills can roll in multiple directions through the bending design of the slide way, so that the first additives are uniformly adhered to the surfaces of the pills, and the degree of roundness of the pills after forming can be improved.
The upper surface of the sliding plate is provided with a flow groove; the flow grooves are communicated with the upper end of the slide way, and the widths of the flow grooves are increased from right to left in sequence; during operation, the first additive is uniformly blown into the surface of the slide way when the fan works, so that the uniformity of the first additive on the surface of the pill is improved, and meanwhile, the air speed can be reduced through the width change of the flow groove, so that the influence of the air blower on the first additive is reduced, and the first additive is prevented from being raised.
The invention has the following beneficial effects:
1. according to the preparation method of the sustained-release preparation containing the ibuprofen pellet, disclosed by the invention, the addition of the additive I and the additive II can improve the drug effect of the ibuprofen, improve the physique and immunity of patients and assist the recovery of the patients, and the citrus peel and the dried lily powder can adjust the taste of the pill, assist the old to swallow the pill and improve the drug property.
2. According to the preparation method of the sustained-release preparation containing the ibuprofen pellets, the medicine bolus passing through the pulp coating port is automatically coated with pulp by arranging the electric telescopic rod, the roller and the pulp coating port, so that the taste of the medicine is improved while manpower and material resources are saved, and the conflict psychology of patients on the medicine is reduced.
Drawings
The invention will be further explained with reference to the drawings.
FIG. 1 is a flow chart of a method of the present invention;
FIG. 2 is a cross-sectional view of a slurry containment apparatus used in the present invention;
FIG. 3 is a perspective view of the skateboard of FIG. 2;
in the figure: the device comprises a fixed box 1, a partition plate 11, a material supplementing bin 12, a material discharging bin 13, a material inlet 14, an electric telescopic rod 15, a roller 16, a water-absorbing cotton cloth layer 17, a pulp coating port 18, a sliding plate 19, a slide way 191, a flow groove 192, an extrusion barrel 2, a screw 21, an extrusion hole 22, a fixed plate 3, a cavity 31, a second gear 32, a first gear 33, a transmission shaft 34, a cutting knife 35, a connecting plate 4, a blower 41 and a powder box 42.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
As shown in figures 1 to 3, the sustained release preparation containing ibuprofen pellet of the present inventionThe preparation method of the sustained release preparation containing ibuprofen pellets comprises the following raw materials: 30-40 parts of ibuprofen powder, wherein the molecular formula of the ibuprofen is as follows:
5-15 parts of additive I, 10-15 parts of additive II, 1-3 parts of microcrystalline cellulose (the main component of the microcrystalline cellulose is a linear chain polysaccharide substance combined by beta-1, 4-glucoside bonds), 1-3 parts of hydroxypropyl methylcellulose (prepared by selecting high-purity cotton cellulose as a raw material and carrying out special etherification under an alkaline condition), and 10-15 parts of a dissolving solution; the preparation method comprises the following steps:
s1: adding the ibuprofen powder and the microcrystalline cellulose into a mixer, stirring for 10-15 minutes, adding the additive, continuously stirring, and mixing and stirring uniformly to obtain a mixed raw material;
s2: the dissolving solution and the hydroxypropyl methylcellulose in the raw materials are jointly placed in a mixer to be stirred for 30-50 minutes, the hydroxypropyl methylcellulose is continuously added in the stirring process, so that the hydroxypropyl methylcellulose is completely dissolved in the dissolving solution, a paste-like substance which can be sprayed out by a spray head is obtained to be used as an adhesive, and the dosage of the hydroxypropyl methylcellulose can be better controlled by adding the hydroxypropyl methylcellulose while stirring and mixing so as to reach the most suitable concentration and improve the bonding effect of the adhesive;
s3: spraying partial solution on the surface of the mixed raw material obtained in the step S1, drying the mixed raw material at the high temperature of 20-35 ℃ for 5-10 minutes, putting the dried mixed raw material into a pill making machine, uniformly spraying the adhesive obtained in the step S2 on the surface of the mixed raw material through an automatic spray head, centrifuging the mixture to prepare pellets, adding the solution into the mixed raw material before introducing the mixed raw material into the pill making machine, so that partial nutrient substances in the solution can enter the mixed raw material, the drug effect of the mixed raw material is improved, and meanwhile, the adhesive can be prevented from being too sticky and affecting the adhesive effect of the mixed raw material;
s4: placing the pellets prepared in the step S3 in an extrusion barrel 2 of a slurry packaging device, placing an additive II in a material supplementing bin 12 of the slurry packaging device, adding the additive I into a powder box 42, and starting the slurry packaging device;
the additive I is a mixture obtained by mixing powder obtained by naturally drying and crushing orange peels and dried lily powder obtained by drying and crushing lily petals at 25-35 ℃ according to a ratio of 1:3, the volatile oil content in the orange peels can be effectively reduced and the content of compounds in flavonoid in the orange peels can be increased through natural air drying of the orange peels, so that the medicinal value of the orange peels is improved, the orange peels have the effects of promoting qi circulation, invigorating stomach, eliminating dampness and phlegm and the like, and can assist ibuprofen to improve the treatment effect of the ibuprofen on rheumatic diseases, the dried lily has the effects of detoxifying, strengthening spleen and stomach, promoting diuresis, removing food retention, calming the heart and tranquilizing the mind, promoting blood circulation and the like, and can assist the ibuprofen to treat rheumatism and assist patients to expel toxins and enhance the physique of patients.
The dissolving solution is a filtrate obtained by mixing orange peel and lily petals according to a ratio of 3:1 after the orange peel and the lily petals are sterilized under the condition of full drying, and filtering after fermenting for 10-30 days by alcohol, the orange peel and the dried lily are fermented, ethanol is generated in the fermentation process, the hydroxypropyl methylcellulose can be fully dissolved by the ethanol to obtain an adhesive, and the ethanol contains more beneficial substances in the orange peel and the dried lily, so that the recovery speed of patients can be improved, the drug effect is improved, the recovery of the patients is benefited, and the pain feeling of the patients can be reduced by the ethanol, so that the sleep of the patients is assisted.
Ethanol
The second additive is a sticky substance obtained by mixing orange peel and lily petals according to the proportion of 3:1 after being sterilized under the condition of fully drying, fermenting for 10-30 days by alcohol, filtering to obtain filter residue, drying the filter residue at the high temperature of 30-50 ℃, crushing to obtain powder, and intermittently adding a dissolving solution into the powder in a stirrer; the citrus peel and lily petals still contain a large amount of beneficial substances after fermentation, and viruses and bacteria contained in the citrus peel and lily petals can be greatly killed after double operations of fermentation and drying, so that the treatment and recovery of patients are assisted after the citrus peel and lily petals are taken, and the physique of the patients is enhanced.
The pulp wrapping device used in the step S4 comprises a fixed box 1, an extrusion barrel 2 and a controller; the extrusion barrel 2 is fixedly connected to the top of the fixed box 1 through a fixed rod; the upper surface of the right end of the extrusion barrel 2 is fixedly connected with a fixed plate 3; the upper surface of the fixed plate 3 is fixedly connected with a motor, and the motor is electrically connected with a controller; a driving shaft of the motor penetrates through the fixing plate 3 and is fixedly connected with a screw rod 21 in the extrusion barrel 2; the bottom of the extrusion barrel 2 is provided with an extrusion hole 22; the side wall of the extrusion hole 22 is designed into a cambered surface; a cavity 31 is formed in the fixing plate 3; a first gear 33 is fixedly sleeved on the surface of the part of the rotating shaft of the motor in the cavity 31; a second gear 32 is rotationally connected in the cavity 31; the second gear 32 is meshed with the first gear 33; the lower surface of the second gear 32 is fixedly connected with a transmission shaft 34; the lower end of the transmission shaft 34 extends to the bottom of the extrusion barrel 2, uniformly arranged cutting knives 35 are fixedly sleeved on the surface of the transmission shaft 34, and the upper surfaces of the cutting knives 35 are designed to be close to the bottom of the extrusion barrel 2; a partition plate 11 is fixedly connected in the fixed box 1, and the partition plate 11 is designed to be inclined; the space in the fixed box 1 is divided into a material supplementing bin 12 and a material discharging bin 13 by the partition plate 11; the material supplementing bin is 12 above the partition plate 11; the top of the fixed box 1 is provided with a feeding hole 14 corresponding to the extrusion hole 22; the inner wall of the left side of the fixed box 1 is fixedly connected with an electric telescopic rod 15 through a fixed seat, and the electric telescopic rod 15 is electrically connected with a controller; the driving end of the electric telescopic rod 15 is rotatably connected with a roller 16, and the roller 16 is partially soaked in the additive II in an initial state; the surface of the roller 16 is wrapped with a water-absorbing cotton cloth layer 17; the electric telescopic rod 15 is positioned in the material supplementing bin 12 and is designed in parallel with the partition plate 11; a charging hole is formed in the left side of the fixed box 1 and is positioned above the electric telescopic rod 15; the surface of the clapboard 11 is provided with a pulp coating port 18 corresponding to the position of the feed port 14; a sliding plate 19 is fixedly connected in the fixed box 1; the sliding plate 19 is designed to be inclined, and the inclined part is designed to be close to the pulp wrapping port 18; the outer wall of the left side of the fixed box 1 is fixedly connected with a discharge hole, and the left end of the sliding plate 19 extends to the discharge hole; when the device works, when the pellets are placed in the extrusion barrel 2 of the slurry coating device, the additive II is placed in the supplement bin 12 of the slurry coating device, the additive I is added into the powder box 42, the motor is controlled by the controller to be started, the motor rotates to drive the screw 21 to rotate, the pellets are extruded and mixed through the screw 21 to form a drug mass, the drug mass is extruded through the extrusion hole 22, the cutting knife 35 is driven to rotate through the meshing of the first gear 33 and the second gear 32 in the rotating process of the motor, the drug mass extruded from the extrusion hole 22 is cut intermittently by the cutting knife 35, the cut drug mass falls into the fixed box 1 through the feeding hole 14 and passes through the slurry coating port 18, the controller controls the electric telescopic rod 15 to complete one group of expansion and contraction before the drug mass passes through the slurry coating port 18, the roller 16 rotates in the extending process of the electric telescopic rod 15 and passes through the slurry coating port 18, the water absorption cotton layer on the surface of the roller 16 is used, when the medicinal mass passes through the pulp coating port 18, the film formed by the additive II is wrapped on the surface of the medicinal mass, so that the content of citrus peel powder and lily petal powder in the medicinal mass can be increased, the bitter taste of the medicinal mass is reduced, the medicinal property of the medicinal mass is improved, the medicinal mass drops to the surface of the sliding plate 19 after passing through the pulp coating port 18 and rolls on the surface of the sliding plate 19, and more regular pills can be formed in the rolling process of the medicinal mass, so that the color value of the pills is increased, and the medicinal pills are more mellow.
The outer wall of the right side of the fixed box 1 is fixedly connected with a connecting plate 4; the upper surface of the connecting plate 4 is fixedly connected with a blower 41, and the blower 41 is electrically connected with a controller; a powder box 42 is arranged at an air outlet of the air blower 41; the powder box 42 is fixedly connected to the outer wall of the right side of the fixed box 1, the powder box 42 is communicated to a gap between the partition plate 11 and the sliding plate 19, meanwhile, the powder box 42 is communicated with an air outlet of the air blower 41, an opening is formed in the top of the powder box 42, and a sealing plug is arranged in the opening; during operation, when electric telescopic handle 15 stretches out, controller control air-blower 41 starts, air-blower 41 drives the additive in the powder case 42 and blows to slide 19 surface once, the pellet is at slide 19 surface roll in-process surface adhesion additive one on the surface, thereby improve the content of citrus peel and dry lily powder in the pellet, thereby reach the improvement pellet drug effect of maximize, citrus peel and lily petal powder adhesion are in the pellet surface simultaneously, can prevent that the pellet from adhering to slide 19 surface, cause the circumstances of the interior medicine content reduction of pellet, pollute slide 19 surface simultaneously, cause the pellet can't form comparatively regular pellet after slide 19 surface, influence the pellet shape.
The upper surface of the sliding plate 19 is provided with a slideway 191; the slideway 191 is designed in an oval shape at the position corresponding to the pulp coating port 18, and the slideway 191 is designed in a bending way from right to left; when the pill dropping device works, pills fall onto the surface of the sliding plate 19, enter the slide way 191 and roll through the slide way 191, and the pills can roll in multiple directions through the bending design of the slide way 191, so that the first additive is uniformly adhered to the surfaces of the pills, and the degree of smoothness of the pills after forming can be improved.
The upper surface of the sliding plate 19 is provided with a flow groove 192; the flow grooves 192 are communicated with the upper end of the slide channel 191, and the widths of the flow grooves 192 increase from right to left; during operation, the first additive is uniformly blown into the surface of the slideway 191 when the fan works, so that the uniformity of the first additive on the surface of the pill is improved, and meanwhile, the air speed can be reduced through the width change of the flow groove 192, so that the influence of the blower 41 on the first additive is reduced, and the first additive is prevented from being raised.
When the mixing machine works, the ibuprofen powder and the microcrystalline cellulose which are used as raw materials are added into the mixing machine to be stirred for 10-15 minutes, then the additive is added to be continuously stirred, and mixed raw materials are obtained after the materials are fully and uniformly mixed and stirred; putting the solution and hydroxypropyl methylcellulose in the raw materials into a mixer together, stirring for 30-50 minutes, and continuously adding the hydroxypropyl methylcellulose in the stirring process to completely dissolve the hydroxypropyl methylcellulose in the solution to obtain a paste-like substance which can be sprayed out by a spray head and is used as an adhesive; spraying partial solution on the surface of the obtained mixed raw material, drying the mixed raw material at the high temperature of 20-35 ℃ for 5-10 minutes, putting the dried mixed raw material into a pill making machine, uniformly spraying an adhesive on the surface of the mixed raw material through an automatic spray head, and centrifuging to prepare pellets; placing the pellets in an extrusion barrel 2 of a slurry packaging device, placing an additive II in a feeding bin 12 of the slurry packaging device, adding the additive I into a powder box 42, controlling a motor to start through a controller, driving a screw 21 to rotate through the rotation of the motor, extruding and mixing the pellets through the screw 21 to form a drug mass, extruding the drug mass through an extrusion hole 22, driving a cutting knife 35 to rotate through the meshing of a first gear 33 and a second gear 32 in the rotation process of the motor, enabling the cutting knife 35 to intermittently cut the drug mass extruded from the extrusion hole 22, enabling the cut drug mass to fall into a fixed box 1 through a feeding hole 14 and pass through a slurry packaging port 18, controlling an electric telescopic rod 15 to complete a group of expansion and contraction through the controller before the drug mass passes through the slurry packaging port 18, enabling a roller 16 to rotate in the extension process of the electric telescopic rod 15 and pass through the slurry packaging port 18, and enabling the additive II to form a film at the slurry packaging port 18 through a water, when the medicine group passes through the pulp coating port 18, a film formed by the additive II wraps the surface of the medicine group, the medicine group drops to the surface of the sliding plate 19 after passing through the pulp coating port 18 and rolls on the surface of the sliding plate 19, so that the medicine group can form pills in the rolling process, when the electric telescopic rod 15 extends out, the controller controls the air blower 41 to be started, the air blower 41 drives the additive in the powder box 42 to blow to the surface of the sliding plate 19, the additive I is adhered to the surface of the medicine group in the rolling process of the surface of the sliding plate 19, and the pills drop to the surface of the sliding plate 19, enter the slideway 191 and roll to the discharge port through the slideway 191.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (1)
1. A preparation method of a sustained-release preparation containing ibuprofen pellets is characterized in that: the raw materials comprise: 30-40 parts of ibuprofen powder, 5-15 parts of additive I, 10-15 parts of additive II, 1-3 parts of microcrystalline cellulose, 1-3 parts of hydroxypropyl methylcellulose and 10-15 parts of dissolving solution; the preparation method comprises the following steps:
s1: adding the ibuprofen powder and the microcrystalline cellulose into a mixer, stirring for 10-15 minutes, adding the additive, continuously stirring, and mixing and stirring uniformly to obtain a mixed raw material;
s2: putting the solution and hydroxypropyl methylcellulose in the raw materials into a mixer together, stirring for 30-50 minutes, and continuously adding the hydroxypropyl methylcellulose during stirring to completely dissolve the hydroxypropyl methylcellulose into the solution to obtain a paste-like substance which can be sprayed out by a spray head and is used as an adhesive;
s3: spraying partial solution on the surface of the mixed raw material obtained in the step S1, drying the mixed raw material at the high temperature of 20-35 ℃ for 5-10 minutes, putting the dried mixed raw material into a pill making machine, uniformly spraying the adhesive obtained in the step S2 on the surface of the mixed raw material through an automatic spray head, and centrifuging to prepare pellets;
s4: placing the pellets prepared in the S3 into an extrusion barrel (2) of a slurry packaging device, placing an additive II into a replenishing bin (12) of the slurry packaging device, adding the additive I into a powder box (42), and starting the slurry packaging device;
the additive I is a mixture obtained by mixing naturally dried and crushed orange peel powder and dried lily bulb powder obtained by drying and crushing lily petals at 25-35 ℃ according to a ratio of 1: 3;
the dissolving solution is filtrate obtained by sterilizing orange peel and lily petals under the condition of full drying, mixing according to the proportion of 3:1, fermenting for 10-30 days by alcohol and then filtering;
the second additive is a sticky substance obtained by mixing orange peel and lily petals according to the proportion of 3:1 after being sterilized under the condition of fully drying, fermenting for 10-30 days by alcohol, filtering to obtain filter residue, drying the filter residue at the high temperature of 30-50 ℃, crushing to obtain powder, and intermittently adding a dissolving solution into the powder in a stirrer;
the controller controls the motor to start, the motor rotates to drive the screw rod (21) to rotate, the micro-pills are extruded and mixed through the screw rod (21) to be extruded and extruded to form a medicine group, meanwhile, the medicine group is extruded through the extrusion hole (22), the motor rotates to drive the cutting knife (35) to rotate through the meshing of the first gear (33) and the second gear (32), the cutting knife (35) intermittently cuts the medicine group extruded from the extrusion hole (22), the cut medicine group falls into the fixed box (1) through the feed port (14) and penetrates through the pulp coating port (18), before the medicine group penetrates through the pulp coating port (18), the controller controls the electric telescopic rod (15) to complete one group of expansion and contraction, the roller (16) rotates in the extending process of the electric telescopic rod (15), the medicine group passes through the pulp coating port (18), the additive II is formed into a film in the pulp coating port (18) through the water absorption cotton layer on the surface of the roller (16), when the medicine group passes through the pulp, the film formed by the additive II wraps the surface of the drug mass, the drug mass falls to the surface of the sliding plate (19) after passing through the slurry wrapping port (18), rolls on the surface of the sliding plate (19), pills can be formed in the process of rolling of the drug mass, when the electric telescopic rod (15) stretches out, the controller controls the air blower (41) to be started, the air blower (41) drives the additive in the powder box (42) to be blown to the surface of the sliding plate (19), the additive I is adhered to the surface of the drug mass in the process of rolling on the surface of the sliding plate (19), and when the pills fall to the surface of the sliding plate (19), the pills enter the slideway (191) and roll to the discharge port through the slideway (191);
the pulp wrapping device used in the step S4 comprises a fixed box (1), an extrusion barrel (2) and a controller; the extrusion barrel (2) is fixedly connected to the top of the fixed box (1) through a fixed rod; the upper surface of the right end of the extrusion barrel (2) is fixedly connected with a fixed plate (3); the upper surface of the fixed plate (3) is fixedly connected with a motor, and the motor is electrically connected with a controller; a driving shaft of the motor penetrates through the fixing plate (3) and is fixedly connected with a screw rod (21) in the extrusion barrel (2); the bottom of the extrusion barrel (2) is provided with an extrusion hole (22); the side wall of the extrusion hole (22) is designed into a cambered surface; a cavity (31) is formed in the fixing plate (3); a first gear (33) is fixedly sleeved on the partial surface of the rotating shaft of the motor in the cavity (31); a second gear (32) is rotationally connected in the cavity (31); the second gear (32) is meshed with the first gear (33); the lower surface of the second gear (32) is fixedly connected with a transmission shaft (34); the lower end of the transmission shaft (34) extends to the bottom of the extrusion barrel (2), uniformly distributed cutting knives (35) are fixedly sleeved on the surface of the transmission shaft (34), and the upper surfaces of the cutting knives (35) are designed to be close to the bottom of the extrusion barrel (2); a partition plate (11) is fixedly connected in the fixed box (1), and the partition plate (11) is designed in an inclined manner; the space in the fixed box (1) is divided into a material supplementing bin (12) and a material discharging bin (13) by the partition plate (11); the feeding bin (12) is positioned above the partition plate (11); the top of the fixed box (1) is provided with a feed inlet (14) corresponding to the extrusion hole (22); the inner wall of the left side of the fixed box (1) is fixedly connected with an electric telescopic rod (15) through a fixed seat, and the electric telescopic rod (15) is electrically connected with a controller; the driving end of the electric telescopic rod (15) is rotatably connected with a roller (16), and the roller (16) is partially soaked in the additive II in an initial state; the surface of the roller (16) is wrapped with a water absorption cotton cloth layer (17); the electric telescopic rod (15) is positioned in the material supplementing bin (12) and is designed in parallel with the partition plate (11); a charging opening is formed in the left side of the fixed box (1), and is positioned above the electric telescopic rod (15); the surface of the clapboard (11) is provided with a pulp wrapping port (18) corresponding to the position of the feed port (14); a sliding plate (19) is fixedly connected in the fixed box (1); the sliding plate (19) is designed to be inclined, and the inclined part is designed to be close to the pulp wrapping port (18); the outer wall of the left side of the fixed box (1) is fixedly connected with a discharge hole, and the left end of the sliding plate (19) extends to the discharge hole;
the outer wall of the right side of the fixed box (1) is fixedly connected with a connecting plate (4); the upper surface of the connecting plate (4) is fixedly connected with an air blower (41), and the air blower (41) is electrically connected with the controller; a powder box (42) is arranged at an air outlet of the blower (41); the powder box (42) is fixedly connected to the outer wall of the right side of the fixed box (1), the powder box (42) is communicated to a gap between the partition plate (11) and the sliding plate (19), meanwhile, the powder box (42) is communicated with an air outlet of the air blower (41), an opening is formed in the top of the powder box (42), and a sealing plug is arranged in the opening; when the electric telescopic rod works, when the electric telescopic rod (15) extends out, the controller controls the air blower (41) to be started, the air blower (41) drives the additive I in the powder box (42) to be blown to the surface of the sliding plate (19), and the additive I is adhered to the surface of a drug mass in the rolling process of the surface of the sliding plate (19);
the upper surface of the sliding plate (19) is provided with a slideway (191); the slideway (191) is designed in an oval shape at the position corresponding to the pulp coating port (18), and the slideway (191) is designed in a bending way from right to left; when the medicine taking machine works, pills fall onto the surface of the sliding plate (19), enter the slide way (191) and roll through the slide way (191); the upper surface of the sliding plate (19) is provided with a flow groove (192); the flow grooves (192) are communicated with the upper end of the slide rail (191), and the widths of the flow grooves (192) increase from right to left in sequence; when the air blower works, the additive is uniformly blown into the surface of the slideway (191).
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Effective date of registration: 20210610 Address after: No.19 Yunpeng Avenue, Xiangfen Pharmaceutical Industrial Park, Linfen City, Shanxi Province 041500 Patentee after: Yunpeng Pharmaceutical Group Co.,Ltd. Address before: 102600 Beijing Daxing District Zhongguancun Science and Technology Park Daxing Biomedical Industry Base No. 22 Yongwang Road, 4 1-2 floors Patentee before: Beijing Yunpeng Pengcheng Pharmaceutical Technology Co.,Ltd. |
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