CN110436026B - System for storing biological samples - Google Patents
System for storing biological samples Download PDFInfo
- Publication number
- CN110436026B CN110436026B CN201910890835.1A CN201910890835A CN110436026B CN 110436026 B CN110436026 B CN 110436026B CN 201910890835 A CN201910890835 A CN 201910890835A CN 110436026 B CN110436026 B CN 110436026B
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- China
- Prior art keywords
- cavity
- central
- tank body
- storing
- biological sample
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- 239000012472 biological sample Substances 0.000 title claims abstract description 56
- 238000004321 preservation Methods 0.000 claims abstract description 35
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 238000007710 freezing Methods 0.000 claims abstract description 3
- 230000008014 freezing Effects 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims abstract description 3
- 230000008569 process Effects 0.000 claims abstract description 3
- 230000007246 mechanism Effects 0.000 claims description 27
- 238000009413 insulation Methods 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 4
- 230000001276 controlling effect Effects 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000001816 cooling Methods 0.000 description 3
- 239000012774 insulation material Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
- A01N1/0268—Carriers for immersion in cryogenic fluid, both for slow-freezing and vitrification, e.g. open or closed "straws" for embryos, oocytes or semen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N3/00—Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves or protection against physical influences such as UV radiation using chemical compositions; Grafting wax
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/04—Partitions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/38—Devices for discharging contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/38—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
- B65D81/3837—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container in the form of a bottle, jar or like container
- B65D81/3846—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container in the form of a bottle, jar or like container formed of different materials, e.g. laminated or foam filling between walls
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
- Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics
Abstract
The invention discloses a system for storing biological samples, which comprises a tank body, wherein the tank body is provided with a cavity, and the cavity is vertically divided into a first cavity and a second cavity by a heat preservation piece; the upper end of the tank body is opened and is closed by a heat-insulating cover; the heat preservation piece is used for partially thermally isolating the first cavity and the second cavity, so that heat transfer still exists between the first cavity and the second cavity in the freezing process of the biological sample, and when the storage rack generates lifting movement, the storage rack only moves from the second cavity to the first cavity and is always positioned in the tank body. According to the system for storing biological samples, the space inside the tank body is divided into the plurality of cavities through the arrangement of the heat preservation piece, so that the whole cavity of the whole large-volume tank body can be prevented from being cooled before the storage rack is lifted, the loss of liquid nitrogen is reduced, and the excessive rapid dissipation of cold energy can be prevented after the storage rack is lifted, so that the biological samples in the second cavity can be protected.
Description
Technical Field
The present invention relates to a biological material preservation apparatus, and more particularly, to a system for storing biological samples.
Background
The biological sample storage plays an important role in various links of basic medicine, clinical detection and transformation research. In storing a biological sample, the biological sample is generally stored in a low-temperature environment.
The prior art systems for storing biological samples have a tank that is a complete space within which the biological sample is placed; and an opening is formed on the tank body for feeding and taking out the biological sample; however, such a system for storing a biological sample causes a loss of nitrogen gas and wastes a lot of energy when the biological sample is fed in and taken out in use.
Disclosure of Invention
The invention aims to provide a system for storing biological samples, which can avoid cooling the whole cavity of the whole large-volume tank body before lifting the storage rack, reduce liquid nitrogen loss, and prevent cold from dissipating too quickly after the storage rack is lifted so as to protect the biological samples in the second cavity.
The invention solves the technical problems by adopting the following technical scheme: a system for storing a biological sample comprising a canister body having a cavity vertically separated by a thermal insulation into a first cavity and a second cavity; the first cavity is positioned above the second cavity;
the upper end of the tank body is opened and is closed by a heat-insulating cover;
the inner part of the tank body is provided with a top fixing plate, the top fixing plate is positioned below the heat insulation cover, the center of the top fixing plate is provided with a through hole, and the upper end of the central shaft is rotatably arranged in the through hole of the top fixing plate;
the middle part of the central shaft penetrates through the heat preservation piece, the lower end of the central shaft is fixedly provided with a lifting mechanism, the lifting mechanism comprises a plurality of storage racks, the storage racks are uniformly distributed around the axial direction of the central shaft and are all located in the second cavity, and the lifting mechanism can drive the lifting mechanism to realize lifting movement; the heat preservation piece is provided with an opening for the storage rack to pass through;
the controller controls the central shaft to rotate after receiving the access request, and rotates the corresponding storage rack to the position right below the opening; then controlling the lifting mechanism to act, so as to lift the storage rack to the lifting well and execute the access operation on the biological samples; after the access operation is finished, the controller controls the lifting mechanism to act, and the storage rack positioned in the lifting well is put into the second cavity again;
the heat preservation piece is used for partially thermally isolating the first cavity and the second cavity, so that heat transfer still exists between the first cavity and the second cavity in the freezing process of the biological sample, and when the storage rack generates lifting movement, the storage rack only moves from the second cavity to the first cavity and is always positioned in the tank body.
Optionally, two first heat-insulating plates are arranged on the heat-insulating piece, an included angle is formed between the two first heat-insulating plates, and the opening is located in a space enclosed by the two first heat-insulating plates; the upper ends of the two first heat preservation boards are provided with cover boards, and the cover boards seal the upper ends of the two first heat preservation boards.
Optionally, a liquid nitrogen tank center seat is arranged in the tank body; the central ball seat is rotatably arranged on the central seat of the liquid nitrogen tank, and the lower end of the central shaft penetrates through the central ball seat; a central rotating ball is slidably arranged on the central shaft, and the central rotating ball is positioned in the central ball seat; the central shaft and the central rotating ball are coaxially arranged; the central shaft is sleeved with a spring, one end of the spring is propped against a stop block arranged on the central shaft, and the other end of the spring is propped against a central rotating ball.
Optionally, the upper end of the center ball seat is in an inverted cone shape.
Optionally, the central swivel ball is located in an inverted conical portion in the central tee; the outer surface of the central rotating ball is spherical, a through hole is formed in the middle of the central rotating ball, and the central rotating ball is slidably sleeved on the central shaft; and the central swivel ball is also rotatable relative to the central axis.
Optionally, the tank body comprises a tank outer wall and a tank inner wall positioned in the tank outer wall, and a vacuum cavity is formed between the tank outer wall and the tank inner wall; the tank is characterized in that a connecting pipe and a flange plate are formed on the outer wall of the tank body, the flange plate is connected to one end of the heat-insulating pipe, the other end of the heat-insulating pipe is connected to the inner wall of the tank body, and an access opening formed in the inner wall of the tank body corresponds to one end of the heat-insulating pipe.
Optionally, the heat preservation pipe is a corrugated pipe; the wave peaks of the corrugated pipe are at least 2, and the distance between adjacent wave peaks is 2-20mm; the inside of the heat preservation pipe is provided with a heat preservation material, and a channel for the entry and exit of biological samples is formed in the heat preservation material.
Optionally, when the system for storing biological samples is in a storage state, the first cavity and the second cavity have a first temperature difference, and before the storage rack carrying the biological samples to be extracted performs lifting movement, the controller controls the temperature adjusting device to cool the first cavity so that the first cavity and the second cavity have a second temperature difference, and the second temperature difference is smaller than the first temperature difference.
Optionally, when the system for storing biological samples is in a storage state, the temperature within the first cavity is lower than the ambient temperature outside the insulated housing, and the temperature within the second cavity is lower than the temperature within the first cavity.
The invention has the following beneficial effects: according to the system for storing biological samples, the space inside the tank body is divided into the plurality of cavities through the arrangement of the heat preservation piece, so that the whole cavity of the whole large-volume tank body can be prevented from being cooled before the storage rack is lifted, the loss of liquid nitrogen is reduced, and the excessive rapid dissipation of cold energy can be prevented after the storage rack is lifted, so that the biological samples in the second cavity can be protected.
Drawings
FIG. 1 is a schematic diagram of a system for storing biological samples according to the present invention;
fig. 2 is a schematic structural view (with the tank body removed) of the system for storing a biological sample according to the present invention;
FIG. 3 is a schematic diagram of a system for storing biological samples (with the tank body removed) according to the present invention;
FIG. 4 is a schematic view of the structure of the central shaft and lifting mechanism of the present invention;
FIG. 5 is an enlarged schematic view of portion A in FIG. 4;
the labels in the figures are: 101-the outer wall of the tank body; 102-the inner wall of the tank body; 103-a heat preservation piece; 104-a first heat preservation plate; 105-storage rack; 106-cover plate; 107-a second insulation board; 108-connecting pipes; 109-flange plate; 110-insulating pipes; 111-a thermal insulation material; 112-a heat preservation cover; 113-a ventilation valve; 114-top fixed plate; 115-a lifting mechanism; 116-a pressure relief valve; 221-a liquid nitrogen tank center seat; 222-center tee; 223-a center spin ball; 224-a spring; 225-stop; 226-central axis.
Detailed Description
The technical scheme of the invention is further described below with reference to the embodiment and the attached drawings.
Example 1
The present embodiment provides a system for storing biological samples, which comprises a tank body having a cavity vertically divided into a first cavity and a second cavity by a thermal insulation member 103, and preferably, a pressure release valve 116 is provided on the thermal insulation member 103, so that the pressure of the second cavity is kept within a reasonable range by the pressure release valve 116.
The upper end of the tank body is opened and is closed by a heat-insulating cover 112; the heat preservation cover 112 is provided with an air-permeable valve 113.
A top fixing plate 114 is arranged in the tank body, the top fixing plate 114 is positioned below the heat insulation cover 112, a through hole is formed in the center of the top fixing plate 114, and the upper end of the central shaft is rotatably arranged in the through hole of the top fixing plate 114; the upper end of the central shaft 116 is also in transmission connection with an output shaft of a motor, so that the central shaft 226 can rotate under the drive of the motor; preferably, the shaft body is sleeved outside the central shaft 226, a gap exists between the central shaft 226 and the shaft body, and nitrogen can flow in the gap between the central shaft 226 and the shaft body, so that cold insulation of the central shaft 226 and other components is realized.
The inside of the tank body is provided with a liquid nitrogen tank center seat 221, the center ball seat 222 is rotatably arranged on the liquid nitrogen tank center seat 221, the lower end of the center shaft penetrates through the center ball seat, and the upper end of the center ball seat 222 is in an inverted cone shape.
A center rotating ball 223 is slidably disposed on the center shaft 226, and the center rotating ball 223 is located in the center tee 222; more preferably, the central swivel 223 is located in an inverted conical portion of the central tee 222.
The central shaft 226 is arranged coaxially with the central rotating ball 223; the central shaft 226 is sleeved with a spring 224, one end of the spring 224 is propped against a stop 225 arranged on the central shaft 226, and the other end is propped against a central rotating ball 223.
In this embodiment, the outer surface of the central rotating ball 223 is spherical, a through hole is provided in the middle of the central rotating ball 223, and the central rotating ball 223 is slidably sleeved on the central shaft 226; and the center rotating ball 223 is also rotatable with respect to the center shaft 226 such that the center rotating ball 223 is held in the inverted cone-shaped portion of the center tee 222 by the spring 224 to stabilize the center shaft 226.
In this embodiment, use center swivel ball and center ball seat to replace the bearing, and the reliability is good, and not fragile, in addition in the use, center swivel ball wearing and tearing back also can remain to remain the contact with center ball seat all the time under the promotion of compressed spring, stability is good.
The first cavity is located above the second cavity, the middle part of the central shaft passes through the heat insulation part 103, a lifting mechanism 115 is fixed at the lower end of the central shaft 226, the lifting mechanism 115 comprises a plurality of storage frames, the storage frames are uniformly distributed around the axial direction of the central shaft, are located in the second cavity, and can be driven by a lifting mechanism to realize lifting movement; the lifting mechanism can adopt a structure common in the art, and the lifting mechanism can be realized in a mode of driving the ball screw by adopting a motor, and the details are not repeated here.
And the driving mechanism for driving the central shaft to rotate and the driving mechanism for driving the lifting mechanism to lift are arranged on the heat preservation cover, so that the driving mechanism is positioned outside the first cavity.
Preferably, the thermal insulation member 103 is provided with an opening for passing the storage rack, and preferably, the opening may be fan-shaped.
The heat preservation piece 103 is provided with two first heat preservation boards 104, an included angle is formed between the two first heat preservation boards 104, and the opening is located in a space enclosed by the two first heat preservation boards 104, so that a lifting well is formed through the two first heat preservation boards 104, and the storage rack 105 moves from the second cavity to the first cavity through the lifting well and is conveyed to the outside of the tank body, or moves from the first cavity to the second cavity, so that the biological sample is stored in the second cavity.
In this embodiment, the upper ends of the two first heat preservation plates 104 are provided with a cover plate 106, and the cover plate seals the upper ends of the two first heat preservation plates 104; therefore, the function of sealing the lifting well can be achieved, so that when the storage rack is taken out of or put into the second cavity, the space in the first cavity can be cooled as little as possible, namely, only the part in the lifting well can be cooled for the part of the first cavity.
The second heat-insulating plates 107 are arranged at the radial outer ends of the two first heat-insulating plates 104, so that a third chamber is formed among the two first heat-insulating plates 104, the second heat-insulating plates 107 and the cover plate, and a preset gap exists between the lower ends of the second heat-insulating plates 107 and the heat-insulating piece 103, so that a container for storing biological samples enters and exits the tank body through the gap; the opening of the thermal insulation member 103 is formed as an access window, or the lower end of the second thermal insulation plate 107 is formed with an access window, so that a container holding a biological sample can be moved into and out of the can body through the access window.
A channel for the entry and exit of biological samples is formed on the tank body; one end of the channel corresponds to the position of the lifting well; preferably, the tank body includes a tank outer wall 101 and a tank inner wall 102 located in the tank outer wall 101, and a vacuum cavity is formed between the tank outer wall 101 and the tank inner wall 102, so that the tank body has a higher heat insulation effect.
The tank body outer wall 101 is provided with a connecting pipe 108 and a flange plate 109, one end of the connecting pipe 108 is connected with the tank body outer wall 101, the other end of the connecting pipe 108 is connected to the flange plate 109, and an opening and closing door mechanism is fixed on the flange plate 109 so as to close or open the connecting pipe 108 through the opening and closing door mechanism.
The flange plate 109 is connected to one end of the heat insulation pipe 110, and the other end of the heat insulation pipe 110 is connected to the inner wall 102 of the tank body, so that the access opening formed in the inner wall 102 of the tank body corresponds to one end of the heat insulation pipe.
Preferably, the heat-insulating tube 110 is a corrugated tube, i.e. is corrugated, with at least 2 peaks and a peak distance of 20mm; and a thermal insulation material 111 can be arranged in the thermal insulation pipe 110, and a channel for the entry and exit of biological samples is formed in the thermal insulation material, so that the cooling distance is increased through the thermal insulation pipe, and the loss of liquid nitrogen is reduced.
In this embodiment, through setting up of heat preservation spare and first heated board, cut apart into a plurality of cavitys with the inside space of jar body, can avoid cooling the whole cavity of whole bulky jar internal body before promoting the storage rack, reduce liquid nitrogen loss, after the storage rack promotes, also can prevent that the cold volume from dissipating too fast to the biological sample that the protection is located the second cavity.
Preferably, the system for storing biological samples further comprises a controller, which controls the central shaft to rotate and rotates the corresponding storage rack to the position right below the opening after receiving the access request; then controlling the lifting mechanism to act, so as to lift the storage rack to the lifting well and execute the access operation on the biological samples; after the access operation is finished, the controller controls the lifting mechanism to act, and the storage rack positioned in the lifting well is put into the second cavity again, so that the biological sample is saved again.
When the system for storing biological samples is in a storage state, the first cavity and the second cavity have a first temperature difference, and before the storage rack carrying the biological samples to be extracted performs lifting movement, the controller controls the temperature regulating device to cool the first cavity so that the first cavity and the second cavity have a second temperature difference, and the second temperature difference is smaller than the first temperature difference.
In the storage state, the temperature in the first cavity is lower than the ambient temperature outside the insulated housing, and the temperature in the second cavity is lower than the temperature in the first cavity.
The sequence of the above embodiments is only for convenience of description, and does not represent the advantages and disadvantages of the embodiments.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (9)
1. A system for storing a biological sample, comprising a canister body having a cavity vertically separated by a thermal insulation member into a first cavity and a second cavity; the first cavity is positioned above the second cavity;
the upper end of the tank body is opened and is closed by a heat-insulating cover;
the inner part of the tank body is provided with a top fixing plate, the top fixing plate is positioned below the heat insulation cover, the center of the top fixing plate is provided with a through hole, and the upper end of the central shaft is rotatably arranged in the through hole of the top fixing plate;
the middle part of the central shaft penetrates through the heat preservation piece, the lower end of the central shaft is fixedly provided with a lifting mechanism, the lifting mechanism comprises a plurality of storage racks, the storage racks are uniformly distributed around the axial direction of the central shaft and are all located in the second cavity, and the lifting mechanism can drive the lifting mechanism to realize lifting movement; the heat preservation piece is provided with an opening for the storage rack to pass through;
the controller controls the central shaft to rotate after receiving the access request, and rotates the corresponding storage rack to the position right below the opening; then controlling the lifting mechanism to act, so as to lift the storage rack to the lifting well and execute the access operation on the biological samples; after the access operation is finished, the controller controls the lifting mechanism to act, and the storage rack positioned in the lifting well is put into the second cavity again;
the heat preservation piece is used for partially thermally isolating the first cavity and the second cavity, so that heat transfer still exists between the first cavity and the second cavity in the freezing process of the biological sample, and when the storage rack generates lifting movement, the storage rack only moves from the second cavity to the first cavity and is always positioned in the tank body.
2. The system for storing a biological sample according to claim 1, wherein the thermal insulation member is provided with two first thermal insulation plates, an included angle is formed between the two first thermal insulation plates, and the opening is located in a space enclosed by the two first thermal insulation plates; the upper ends of the two first heat preservation boards are provided with cover boards, and the cover boards seal the upper ends of the two first heat preservation boards.
3. The system for storing biological samples according to claim 1, wherein a liquid nitrogen tank center seat is provided inside the tank body; the central ball seat is rotatably arranged on the central seat of the liquid nitrogen tank, and the lower end of the central shaft penetrates through the central ball seat; a central rotating ball is slidably arranged on the central shaft, and the central rotating ball is positioned in the central ball seat; the central shaft and the central rotating ball are coaxially arranged; the central shaft is sleeved with a spring, one end of the spring is propped against a stop block arranged on the central shaft, and the other end of the spring is propped against a central rotating ball.
4. A system for storing biological samples according to claim 3 wherein the upper end of the central tee is inverted cone shaped.
5. The system for storing a biological sample according to claim 4, wherein the central spin ball is located within an inverted conical portion within the central tee; the outer surface of the central rotating ball is spherical, a through hole is formed in the middle of the central rotating ball, and the central rotating ball is slidably sleeved on the central shaft; and the central swivel ball is also rotatable relative to the central axis.
6. The system for storing a biological sample according to claim 5, wherein the canister body comprises a canister outer wall and a canister inner wall within the canister outer wall, the canister outer wall and the canister inner wall forming a vacuum chamber therebetween; the tank is characterized in that a connecting pipe and a flange plate are formed on the outer wall of the tank body, the flange plate is connected to one end of the heat-insulating pipe, the other end of the heat-insulating pipe is connected to the inner wall of the tank body, and an access opening formed in the inner wall of the tank body corresponds to one end of the heat-insulating pipe.
7. The system for storing a biological sample according to claim 6, wherein the insulating tube is a bellows; the wave peaks of the corrugated pipe are at least 2, and the distance between adjacent wave peaks is 2-20mm; the inside of the heat preservation pipe is provided with a heat preservation material, and a channel for the entry and exit of biological samples is formed in the heat preservation material.
8. The system for storing a biological sample according to claim 1, wherein the first and second cavities have a first temperature difference when the system for storing a biological sample is in a storage state, and the controller controls the temperature regulating device to cool the first cavity so that the first and second cavities have a second temperature difference, which is smaller than the first temperature difference, before the storage rack carrying the biological sample to be extracted is subjected to the lifting motion.
9. The system for storing a biological sample according to claim 1, wherein the temperature within the first cavity is lower than the ambient temperature outside the insulated housing and the temperature within the second cavity is lower than the temperature within the first cavity when the system for storing a biological sample is in a storage state.
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| CN111937857B (en) * | 2020-07-03 | 2021-12-10 | 吉林省煜晖生物科技有限公司 | Biological medicine storage device convenient to use |
| CN217625232U (en) * | 2022-05-16 | 2022-10-21 | 上海原能细胞生物低温设备有限公司 | Lifting basket guide mechanism, lifting basket and lifting basket type sample low-temperature storage equipment |
| CN115416978B (en) * | 2022-10-12 | 2023-03-17 | 青岛奥克生物开发有限公司 | Biological tissue suspension type low temperature storage equipment |
| CN116040094B (en) * | 2023-03-28 | 2023-07-14 | 基点生物科技(成都)有限公司 | Sample storage device |
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