CN210654207U - System for storing biological samples - Google Patents
System for storing biological samples Download PDFInfo
- Publication number
- CN210654207U CN210654207U CN201921568221.3U CN201921568221U CN210654207U CN 210654207 U CN210654207 U CN 210654207U CN 201921568221 U CN201921568221 U CN 201921568221U CN 210654207 U CN210654207 U CN 210654207U
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- Prior art keywords
- cavity
- heat
- tank body
- storing
- biological sample
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
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- 239000012472 biological sample Substances 0.000 title claims abstract description 54
- 238000004321 preservation Methods 0.000 claims abstract description 43
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 230000033001 locomotion Effects 0.000 claims abstract description 9
- 238000007710 freezing Methods 0.000 claims abstract description 3
- 230000008014 freezing Effects 0.000 claims abstract description 3
- 238000009413 insulation Methods 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 208000002925 dental caries Diseases 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses a system for storing biological samples, which comprises a tank body, wherein the tank body is provided with a cavity which is vertically divided into a first cavity and a second cavity by a heat preservation piece; the upper end of the tank body is opened and is sealed by a heat-insulating cover; the heat preservation piece partially thermally isolates the first cavity and the second cavity, so that heat transfer still exists in the first cavity and the second cavity during the freezing storage of the biological sample, and when the storage rack generates lifting motion, the storage rack only moves from the second cavity to the first cavity and is always located in the tank body. The utility model discloses a system for storing biological sample passes through the setting of heat preservation piece, cuts apart into a plurality of cavitys with the inside space of jar body, can avoid cooling the whole cavity of the internal body of jar of whole bulky before promoting the storage rack, reduces the liquid nitrogen loss, promotes the back at the storage rack, also can prevent cold volume and dissipate too fast to the protection is located the biological sample of second cavity.
Description
Technical Field
The utility model relates to a biomaterial storage device especially relates to a system for storing biological sample.
Background
Biological sample storage plays an important role in each link of basic medicine, clinical detection and transformation research. In storing biological samples, the biological samples are generally stored in a low temperature environment.
In the prior art, the tank body of the system for storing the biological sample is a complete space, and the biological sample is placed in the space; the tank body is provided with an opening for feeding and taking out the biological sample; however, such a system for storing a biological sample is used, and when the biological sample is taken in and out, nitrogen is lost, and a large amount of energy is wasted.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a system for save biological sample, it can avoid cooling the whole cavity of the internal body of the jar of whole bulky body before promoting the storage rack, reduces the liquid nitrogen loss, promotes the back at the storage rack, also can prevent cold volume too fast dissipation to the protection is located the biological sample of second cavity.
The utility model provides a technical problem adopt following technical scheme: a system for storing a biological sample, comprising a canister body having a cavity vertically separated by a thermal insulation into a first cavity and a second cavity; the first cavity is positioned above the second cavity;
the upper end of the tank body is opened and is sealed by a heat-insulating cover;
a top fixing plate is arranged inside the tank body and is positioned below the heat-insulating cover, a through hole is formed in the center of the top fixing plate, and the upper end of a central shaft is rotatably arranged in the through hole of the top fixing plate;
the middle part of the central shaft penetrates through the heat insulation part, a lifting mechanism is fixed at the lower end of the central shaft and comprises a plurality of storage racks, the storage racks are uniformly distributed around the axial direction of the central shaft, are all positioned in the second cavity and can be driven by the lifting mechanism to realize lifting movement; the heat preservation piece is provided with an opening for the storage rack to pass through;
after receiving the access request, the controller controls the central shaft to rotate and rotates the corresponding storage rack to be right below the opening; then controlling the lifting mechanism to act so as to lift the storage rack to the lifting well and carry out the access operation of the biological samples; after the storing and taking operation is finished, the controller controls the lifting mechanism to act, and the storage rack in the lifting well is placed into the second cavity again;
the heat preservation piece partially thermally isolates the first cavity and the second cavity, so that heat transfer still exists in the first cavity and the second cavity during the freezing storage of the biological sample, and when the storage rack generates lifting motion, the storage rack only moves from the second cavity to the first cavity and is always located in the tank body.
Optionally, two first heat preservation plates are arranged on the heat preservation piece, an included angle is formed between the two first heat preservation plates, and the opening is located in a space enclosed by the two first heat preservation plates; the upper ends of the two first heat-preservation plates are provided with cover plates, and the cover plates seal the upper ends of the two first heat-preservation plates.
Optionally, a liquid nitrogen tank center seat is arranged inside the tank body; the center ball seat is rotatably arranged on the center seat of the liquid nitrogen tank, and the lower end of the center shaft penetrates through the center ball seat; a central rotating ball is slidably arranged on the central shaft and is positioned in the central ball seat; the central shaft and the central rotating ball are coaxially arranged; the central shaft is sleeved with a spring, one end of the spring is propped against a stop block arranged on the central shaft, and the other end of the spring is propped against a central rotating ball.
Optionally, the upper end of the central ball seat is in an inverted cone shape.
Optionally, the central rotating ball is located within an inverted conical portion within the central ball seat; the outer surface of the central rotating ball is spherical, a through hole is formed in the middle of the central rotating ball, and the central rotating ball is slidably sleeved on the central shaft; and the central rotating ball is also able to rotate relative to the central shaft.
Optionally, the tank body comprises a tank outer wall and a tank inner wall located in the tank outer wall, and a vacuum cavity is formed between the tank outer wall and the tank inner wall; the tank body is characterized in that a connecting pipe and a flange plate are formed on the outer wall of the tank body, the flange plate is connected to one end of the heat-insulating pipe, the other end of the heat-insulating pipe is connected to the inner wall of the tank body, and the access opening formed in the inner wall of the tank body corresponds to one end of the heat-insulating pipe.
Optionally, the heat preservation pipe is a corrugated pipe; the number of the wave crests of the corrugated pipe is at least 2, and the distance between the adjacent wave crests is 2-20 mm; the heat preservation pipe is internally provided with a heat preservation material, and a channel for the biological sample to enter and exit is formed in the heat preservation material.
Optionally, when the system for storing the biological sample is in a storage state, the first cavity and the second cavity have a first temperature difference, and before the storage rack carrying the biological sample to be extracted performs lifting motion, the controller controls the temperature adjustment device to cool the first cavity so that the first cavity and the second cavity have a second temperature difference, and the second temperature difference is smaller than the first temperature difference.
Optionally, when the system for storing a biological sample is in a storage state, the temperature in the first cavity is lower than the ambient temperature outside the heat-insulating housing, and the temperature in the second cavity is lower than the temperature in the first cavity.
The utility model discloses following beneficial effect has: the utility model discloses a system for storing biological sample passes through the setting of heat preservation piece, cuts apart into a plurality of cavitys with the inside space of jar body, can avoid cooling the whole cavity of the internal body of jar of whole bulky before promoting the storage rack, reduces the liquid nitrogen loss, promotes the back at the storage rack, also can prevent cold volume and dissipate too fast to the protection is located the biological sample of second cavity.
Drawings
Fig. 1 is a schematic structural view of a system for storing biological samples according to the present invention;
fig. 2 is a schematic structural view of the system for storing biological samples according to the present invention (with the tank body removed);
fig. 3 is a schematic structural view of the system for storing biological samples according to the present invention (with the tank body removed);
fig. 4 is a schematic structural view of the central shaft and the lifting mechanism of the present invention;
FIG. 5 is an enlarged view of portion A of FIG. 4;
the notation in the figures means: 101-the outer wall of the tank body; 102-inner wall of tank body; 103-heat preservation pieces; 104-a first heat preservation plate; 105-a storage rack; 106-cover plate; 107-a second insulation board; 108-connecting tube; 109-flange plate; 110-insulating tube; 111-insulating material; 112-heat preservation cover; 113-a vent valve; 114-top fixation plate; 115-a lifting mechanism; 116-a pressure relief valve; 221-liquid nitrogen tank center seat; 222-a center ball seat; 223-a central rotating ball; 224-a spring; 225-a stop block; 226-center axis.
Detailed Description
The technical solution of the present invention will be further explained with reference to the following embodiments and accompanying drawings.
Example 1
The embodiment provides a system for storing a biological sample, which comprises a tank body, wherein the tank body is provided with a cavity, the cavity is vertically divided into a first cavity and a second cavity by an insulating piece 103, preferably, a pressure relief valve 116 is arranged on the insulating piece 103, so that the pressure of the second cavity is kept within a reasonable range through the pressure relief valve 116.
The upper end of the tank body is opened and is closed by a heat-insulating cover 112; the heat preservation cover 112 is provided with a ventilation valve 113.
A top fixing plate 114 is arranged in the tank body, the top fixing plate 114 is positioned below the heat-insulating cover 112, a through hole is formed in the center of the top fixing plate 114, and the upper end of a central shaft is rotatably arranged in the through hole of the top fixing plate 114; the upper end of the central shaft 116 is also in transmission connection with an output shaft of a motor, so that the central shaft 226 can rotate under the driving of the motor; preferably, a shaft body is sleeved outside the central shaft 226, a gap exists between the central shaft 226 and the shaft body, and nitrogen can flow in the gap between the central shaft 226 and the shaft body, so as to cool the components such as the central shaft 226.
The liquid nitrogen tank central seat 221 is arranged in the tank body, the central ball seat 222 is rotatably arranged on the liquid nitrogen tank central seat 221, the lower end of the central shaft penetrates through the central ball seat, and the upper end of the central ball seat 222 is in an inverted cone shape.
A central rotating ball 223 is slidably disposed on the central shaft 226, and the central rotating ball 223 is located in the central ball seat 222; more preferably, the central rotating ball 223 is located within an inverted conical portion of the central ball seat 222.
The central shaft 226 is coaxially disposed with the central rotary ball 223; the central shaft 226 is sleeved with a spring 224, one end of the spring 224 is propped against a stopper 225 arranged on the central shaft 226, and the other end is propped against a central rotating ball 223.
In this embodiment, the outer surface of the central rotating ball 223 is spherical, a through hole is formed in the middle of the central rotating ball 223, and the central rotating ball 223 is slidably sleeved on the central shaft 226; and the central rotary ball 223 can also rotate with respect to the central shaft 226, so that the central rotary ball 223 is pressed and held by the spring 224 in the reverse tapered portion of the central ball seat 222 to stabilize the central shaft 226.
In this embodiment, use center swivel ball and center ball seat to replace the bearing, and the good reliability, it is not fragile, in the use moreover, the center swivel ball wearing and tearing back also can keep all the time with center ball seat keep in contact under the promotion of the spring of compression, stability is good.
The first cavity is positioned above the second cavity, the middle part of the central shaft penetrates through the heat preservation part 103, the lower end of the central shaft 226 is fixed with a lifting mechanism 115, the lifting mechanism 115 comprises a plurality of storage racks, the storage racks are uniformly distributed around the axial direction of the central shaft, are positioned in the second cavity and can be driven by the lifting mechanism to realize lifting movement; the lifting mechanism can adopt a structure common in the field, and the lifting mechanism can be realized by adopting a mode that a motor drives a ball screw, so that the details are not repeated.
And the driving mechanism for driving the central shaft to rotate and the driving mechanism for driving the lifting mechanism to lift are arranged on the heat-insulating cover, so that the driving mechanism is positioned outside the first cavity.
Preferably, the heat preservation member 103 is provided with an opening for passing the storage rack, and preferably, the shape of the opening may be a sector.
Two first heat preservation plates 104 are arranged on the heat preservation part 103, an included angle is formed between the two first heat preservation plates 104, the opening is located in a space enclosed by the two first heat preservation plates 104, so that a lifting well is formed by the two first heat preservation plates 104, and the storage rack 105 moves from the second cavity to the first cavity through the lifting well and is conveyed to the outside of the tank body, or moves from the first cavity to the second cavity, so that a biological sample is stored in the second cavity.
In this embodiment, the upper ends of the two first heat-insulating plates 104 are provided with a cover plate 106, and the cover plate seals the upper ends of the two first heat-insulating plates 104; therefore, the storage rack can play a role in sealing the lifting well, so that when the storage rack is taken out of the second cavity or put into the second cavity, the space in the first cavity can be cooled as little as possible, namely, the part in the lifting well can be cooled only aiming at the part of the first cavity.
A second heat-insulation plate 107 is arranged at the radial outer ends of the two first heat-insulation plates 104, so that a third chamber is formed among the two first heat-insulation plates 104, the second heat-insulation plate 107 and the cover plate, and a preset gap is formed between the lower end of the second heat-insulation plate 107 and the heat-insulation piece 103, so that a container for storing a biological sample can enter and exit the tank body through the gap; or the opening of the heat preservation member 103 is formed as an access window, or the lower end of the second heat preservation plate 107 is formed with an access window, so that the container for preserving the biological sample can enter and exit the tank body through the access window.
A channel for the biological sample to enter and exit is formed on the tank body; one end of the passage corresponds to the position of the lifting well; preferably, the tank body comprises an outer tank wall 101 and an inner tank wall 102 located inside the outer tank wall 101, and a vacuum cavity is formed between the outer tank wall 101 and the inner tank wall 102, so that the tank body has a high heat insulation effect.
Be formed with connecting pipe 108 and flange board 109 on jar body outer wall 101, the one end of connecting pipe 108 with jar body outer wall 101 is connected, the other end of connecting pipe 108 connect in on the flange board 109, be fixed with the switching door mechanism on the flange board 109, with pass through the switching door mechanism seals or opens connecting pipe 108.
The flange plate 109 is connected to one end of a heat insulation pipe 110, the other end of the heat insulation pipe 110 is connected to the inner wall 102 of the tank body, and an access opening formed in the inner wall 102 of the tank body corresponds to one end of the heat insulation pipe.
Preferably, the thermal insulation pipe 110 is a corrugated pipe, i.e. corrugated, the number of wave crests is at least 2, and the distance between the wave crests is 20 mm; and the heat preservation material 111 can be arranged in the heat preservation pipe 110, and a passage for the biological sample to enter and exit is formed in the heat preservation material, so that the cold conduction distance is increased through the heat preservation pipe, and the loss of liquid nitrogen is reduced.
In this embodiment, through the setting of heat preservation piece and first heat preservation board, divide into a plurality of cavitys with the inside space of jar body, can avoid cooling the whole cavity of the internal body of the jar of whole bulky body before promoting the storage rack, reduce the liquid nitrogen loss, promote the back at the storage rack, also can prevent cold volume too fast dissipation to the biological sample that the protection is located the second cavity.
Preferably, the system for storing biological samples further comprises a controller, wherein the controller controls the central shaft to rotate and rotate the corresponding storage rack to be right below the opening after receiving the access request; then controlling the lifting mechanism to act so as to lift the storage rack to the lifting well and carry out the access operation of the biological samples; after the storing and taking operation is finished, the controller controls the lifting mechanism to act, the storage rack positioned in the lifting well is placed into the second cavity again, and the biological sample is stored again.
When a system for storing biological samples is in a storage state, the first cavity and the second cavity have a first temperature difference, and before a storage rack carrying the biological samples to be extracted is subjected to lifting motion, the controller controls the temperature adjusting device to cool the first cavity so that the first cavity and the second cavity have a second temperature difference, wherein the second temperature difference is smaller than the first temperature difference.
In a storage state, the temperature in the first cavity is lower than the ambient temperature outside the insulated housing, and the temperature in the second cavity is lower than the temperature in the first cavity.
The sequence of the above embodiments is only for convenience of description and does not represent the advantages and disadvantages of the embodiments.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention in its corresponding aspects.
Claims (9)
1. A system for storing biological samples, which is characterized by comprising a tank body, wherein the tank body is provided with a cavity which is vertically divided into a first cavity and a second cavity by a heat preservation piece; the first cavity is positioned above the second cavity;
the upper end of the tank body is opened and is sealed by a heat-insulating cover;
a top fixing plate is arranged inside the tank body and is positioned below the heat-insulating cover, a through hole is formed in the center of the top fixing plate, and the upper end of a central shaft is rotatably arranged in the through hole of the top fixing plate;
the middle part of the central shaft penetrates through the heat insulation part, a lifting mechanism is fixed at the lower end of the central shaft and comprises a plurality of storage racks, the storage racks are uniformly distributed around the axial direction of the central shaft, are all positioned in the second cavity and can be driven by the lifting mechanism to realize lifting movement; the heat preservation piece is provided with an opening for the storage rack to pass through;
after receiving the access request, the controller controls the central shaft to rotate and rotates the corresponding storage rack to be right below the opening; then controlling the lifting mechanism to act so as to lift the storage rack to the lifting well and carry out the access operation of the biological samples; after the storing and taking operation is finished, the controller controls the lifting mechanism to act, and the storage rack in the lifting well is placed into the second cavity again;
the heat preservation piece partially thermally isolates the first cavity and the second cavity, so that heat transfer still exists in the first cavity and the second cavity during the freezing storage of the biological sample, and when the storage rack generates lifting motion, the storage rack only moves from the second cavity to the first cavity and is always located in the tank body.
2. The system for storing a biological sample according to claim 1, wherein the heat-retaining member is provided with two first heat-retaining plates, and an included angle is formed between the two first heat-retaining plates, so that the opening is located in a space enclosed by the two first heat-retaining plates; the upper ends of the two first heat-preservation plates are provided with cover plates, and the cover plates seal the upper ends of the two first heat-preservation plates.
3. The system for storing biological samples according to claim 1, wherein the tank body is internally provided with a liquid nitrogen tank center seat; the center ball seat is rotatably arranged on the center seat of the liquid nitrogen tank, and the lower end of the center shaft penetrates through the center ball seat; a central rotating ball is slidably arranged on the central shaft and is positioned in the central ball seat; the central shaft and the central rotating ball are coaxially arranged; the central shaft is sleeved with a spring, one end of the spring is propped against a stop block arranged on the central shaft, and the other end of the spring is propped against a central rotating ball.
4. The system for storing biological samples of claim 3, wherein the upper end of the central ball seat is reverse tapered.
5. The system for storing biological samples of claim 4, wherein the central rotating ball is located within an inverted conical portion within the central ball seat; the outer surface of the central rotating ball is spherical, a through hole is formed in the middle of the central rotating ball, and the central rotating ball is slidably sleeved on the central shaft; and the central rotating ball is also able to rotate relative to the central shaft.
6. The system for storing a biological specimen according to claim 5, wherein the canister body comprises an outer canister wall and an inner canister wall within the outer canister wall, the outer canister wall and the inner canister wall forming a vacuum chamber therebetween; the tank body is characterized in that a connecting pipe and a flange plate are formed on the outer wall of the tank body, the flange plate is connected to one end of the heat-insulating pipe, the other end of the heat-insulating pipe is connected to the inner wall of the tank body, and the access opening formed in the inner wall of the tank body corresponds to one end of the heat-insulating pipe.
7. The system for storing a biological specimen of claim 6, wherein the thermal tube is a corrugated tube; the number of the wave crests of the corrugated pipe is at least 2, and the distance between the adjacent wave crests is 2-20 mm; the heat preservation pipe is internally provided with a heat preservation material, and a channel for the biological sample to enter and exit is formed in the heat preservation material.
8. The system for storing a biological sample of claim 1, wherein the first chamber and the second chamber have a first temperature difference when the system for storing a biological sample is in a storage state, and wherein the controller controls the temperature adjustment device to cool the first chamber such that the first chamber and the second chamber have a second temperature difference before the rack carrying the biological sample to be extracted performs the lifting motion, the second temperature difference being less than the first temperature difference.
9. The system for storing a biological sample of claim 1, wherein the temperature within the first cavity is lower than an ambient temperature outside of the insulated housing and the temperature within the second cavity is lower than the temperature within the first cavity when the system for storing a biological sample is in a storage state.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921568221.3U CN210654207U (en) | 2019-09-20 | 2019-09-20 | System for storing biological samples |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921568221.3U CN210654207U (en) | 2019-09-20 | 2019-09-20 | System for storing biological samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210654207U true CN210654207U (en) | 2020-06-02 |
Family
ID=70822226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921568221.3U Withdrawn - After Issue CN210654207U (en) | 2019-09-20 | 2019-09-20 | System for storing biological samples |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210654207U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110436026A (en) * | 2019-09-20 | 2019-11-12 | 上海原能细胞生物低温设备有限公司 | A kind of system for storing biological sample |
| CN115251043A (en) * | 2022-07-29 | 2022-11-01 | 冰山松洋生物科技(大连)有限公司 | Sample storage structure and liquid nitrogen biological container thereof |
-
2019
- 2019-09-20 CN CN201921568221.3U patent/CN210654207U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110436026A (en) * | 2019-09-20 | 2019-11-12 | 上海原能细胞生物低温设备有限公司 | A kind of system for storing biological sample |
| CN110436026B (en) * | 2019-09-20 | 2024-01-23 | 上海原能细胞生物低温设备有限公司 | System for storing biological samples |
| CN115251043A (en) * | 2022-07-29 | 2022-11-01 | 冰山松洋生物科技(大连)有限公司 | Sample storage structure and liquid nitrogen biological container thereof |
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