CN110420296A - 一种气虚型体质健脾益气、养血止痒的中药组合物 - Google Patents

一种气虚型体质健脾益气、养血止痒的中药组合物 Download PDF

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CN110420296A
CN110420296A CN201910836729.5A CN201910836729A CN110420296A CN 110420296 A CN110420296 A CN 110420296A CN 201910836729 A CN201910836729 A CN 201910836729A CN 110420296 A CN110420296 A CN 110420296A
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Prior art keywords
parts
radix
fruit
chinese medicine
rhizoma
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丁群
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Guizhou Cimingtang Health Management Co Ltd
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Guizhou Cimingtang Health Management Co Ltd
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Abstract

一种气虚型体质健脾益气、养血止痒的中药组合物，中药组合物由下述重量份的药材配制而成：党参，焦白术，茯苓，山药，焦扁豆，炙黄芪，制首乌，熟地黄，当归，大白芍，山萸肉，金樱子，制黄精，枸杞子，女贞子，旱莲草，丹参，川芎，仙鹤草，肥玉竹，知母，鸡内金，桔梗，姜半夏，陈皮，夜交藤，酸枣仁，柏子仁，白鲜皮，防风，火麻仁，大腹皮，瓜蒌皮，焦山楂，焦六曲，生甘草，淮小麦，大枣，生晒参，西洋参。本发明的中药组合物尤其适用于气血两虚之皮肤干燥瘙痒的老年人群。

Description

一种气虚型体质健脾益气、养血止痒的中药组合物
技术领域
本发明涉及一种气虚型体质健脾益气、养血止痒的中药组合物，具体为中药制备技术领域。
背景技术
老年性皮肤瘙痒症是临床常见病、多发病。祖国医学属于“风瘙痒”、“痒风”范畴。主要是由于风、湿、热之邪客于皮肤肌表，引起皮肉间气血不和，或由于血虚风燥阻于皮肤间，肤失濡养而成。早在《诸病源候论·风瘙痒候》既有“风瘙痒者，是体虚受风，风入腠理，与气血相搏，而俱往来在于皮肤之间。邪气微，不能冲击为痛，故但瘙痒也。”此症的发生主要由于年老体虚，肝肾不足，精血亏损，皮肤得不到精血的濡养而致皮肤干燥、粗糙、瘙痒，加之湿性牯腻与风邪相搏于肌肤腠理之间，阻碍气血运行，使瘙痒更甚。
老年人瘙痒症的治疗是一个很棘手的问题。由于患者体力和智力减退，不能使用外用药物，依从性下降成为主要问题。并且多数患者多种疾病并存，特别是肝肾功能障碍和服用多种药物的副作用。目前，还没有针对每个人都可以接受的治疗方案。老年人瘙痒的控制，要考虑到人体的一般健康状况、症状的严重程度、治疗的副作用。找到和去除诱发因素是有效治疗的关键。局部治疗以止痒和防止感染为原则。目前临床上以外用抗炎、抗过敏、止痒软膏，如百多邦、宝龙康、艾洛松等，口服抗组胺药如开瑞坦、氯雷他定等，镇静剂安定，复合维生素、钙剂等为主。中药是我国宝贵的资源，国内多家文献报道表明中医药治疗老年性皮肤瘙痒病具有良好的临床疗效和优势。
发明内容
本发明的目的在于提供一种气虚型体质健脾益气、养血止痒的中药组合物。
为实现上述目的，本发明提供如下技术方案：一种气虚型体质健脾益气、养血止痒的中药组合物由下述重量份的药材配制而成：党参10-150份，焦白术10-150份，茯苓10-150份，山药10-150份，焦扁豆10-150份，炙黄芪200-300，制首乌10-150份，熟地黄100-200份，当归10-120份，大白芍10-150份，山萸肉10-90份，金樱子10-900份，制黄精10-120份，枸杞子10-120份，女贞子10-100份，旱莲草100-300份，丹参20-200份，川芎10-90份，仙鹤草100-300份，肥玉竹10-120份，知母10-90份，鸡内金10-120份，桔梗10-90份，姜半夏10-90份，陈皮10-90份，夜交藤5-30份，酸枣仁10-90份，柏子仁10-90份，白鲜皮10-150份，防风10-90份，火麻仁10-90份，大腹皮10-90份，瓜蒌皮10-150份，焦山楂10-120份，焦六曲10-150份，生甘草5-30份，淮小麦100-200份，大枣100-200份，生晒参5-50份，西洋参5-50份。
作为优选，所述的气虚型体质健脾益气、养血止痒的中药组合物由下述重量份的药材配制而成：党参120份，焦白术120份，茯苓120份，山药120份，焦扁豆120份，炙黄芪150份，制首乌120份，熟地黄150份，当归80份，大白芍120份，山萸肉70份，金樱子600份，制黄精80份，枸杞子80份，女贞子80份，旱莲草200份，丹参100份，川芎80份，仙鹤草200份，肥玉竹80份，知母80份，鸡内金100份，桔梗80份，姜半夏80份，陈皮80份，夜交藤25份，酸枣仁70份，柏子仁70份，白鲜皮120份，防风80份，火麻仁80份，大腹皮80份，瓜蒌皮120份，焦山楂100份，焦六曲120份，生甘草20份，淮小麦150份，大枣150份，生晒参35份，西洋参35份。
一种气虚型体质健脾益气、养血止痒的中药组合物的制备方法为：步骤一、将中药组合物按照重量份原料配比，将党参，焦白术，茯苓，山药，焦扁豆，炙黄芪，制首乌，熟地黄，当归，大白芍，山萸肉，金樱子，制黄精，枸杞子，女贞子，旱莲草，丹参，川芎，仙鹤草，肥玉竹，知母，鸡内金，桔梗，姜半夏，陈皮，夜交藤，酸枣仁，柏子仁，白鲜皮，防风，火麻仁，大腹皮，瓜蒌皮，焦山楂，焦六曲，生甘草，淮小麦，大枣，生晒参，西洋参全部粉碎成粉末，将粉碎的药材粉末全部投入超临界流体萃取反应釜中，然后加入改性剂乙醇0.3ml，萃取条件为压力34.5mPa，温度60℃，静态萃取时间10min，动态萃取量10ml，以水作为吸引，得到纯度很高的药粉；
步骤二、炼蜜，熬炼蜂蜜，先用武火，熬沸腾后改为文火缓熬；
步骤三、调药，将熬炼好的蜂蜜用勺子倒入步骤一制备的药粉内，同时用粗竹筷在药粉内成圆周搅动，边倒步骤二熬炼的蜂蜜边调药粉，以基本上看不到药粉时停止加蜜，调好后，用消毒的双手在盆中和为药团；
步骤四、搓条、和丸，和丸时用少许芝麻油、点掌心以使药丸光亮；
步骤五、包装：将药丸晒干或红外线灯烤干，用无毒瓶密储干燥阴凉处。
本方主要是对血虚风燥之症的患者。“虚者补之”而治，宜养血润肤，祛风止痒。方用当归饮子加减为主，用之治疗血虚风燥的顽疾。服药时注意保持居处的适当温度，防皮肤干燥和突然受冷，多食蔬菜、水果，忌食辛辣刺激食品和酒类。
与现有技术相比，本发明的有益效果如下：本发明的中药组合物尤其适用于气血两虚之皮肤干燥瘙痒的老年人群。
具体实施方式
下面将结合本发明实施例中对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
一种气虚型体质健脾益气、养血止痒中药组合物的制备方法为：步骤一、将中药组合物按照重量份原料配比，将党参10-150份，焦白术10-150份，茯苓10-150份，山药10-150份，焦扁豆10-150份，炙黄芪200-300，制首乌10-150份，熟地黄100-200份，当归10-120份，大白芍10-150份，山萸肉10-90份，金樱子10-900份，制黄精10-120份，枸杞子10-120份，女贞子10-100份，旱莲草100-300份，丹参20-200份，川芎10-90份，仙鹤草100-300份，肥玉竹10-120份，知母10-90份，鸡内金10-120份，桔梗10-90份，姜半夏10-90份，陈皮10-90份，夜交藤5-30份，酸枣仁10-90份，柏子仁10-90份，白鲜皮10-150份，防风10-90份，火麻仁10-90份，大腹皮10-90份，瓜蒌皮10-150份，焦山楂10-120份，焦六曲10-150份，生甘草5-30份，淮小麦100-200份，大枣100-200份，生晒参5-50份，西洋参5-50份全部粉碎成粉末，将粉碎的药材粉末全部投入超临界流体萃取反应釜中，然后加入改性剂乙醇0.3ml，萃取条件为压力34.5mPa，温度60℃，静态萃取时间10min，动态萃取量10ml，以水作为吸引，得到纯度很高的药粉；
步骤二、炼蜜，熬炼蜂蜜，先用武火，熬沸腾后改为文火缓熬；
步骤三、调药，将熬炼好的蜂蜜用勺子倒入步骤一制备的药粉内，同时用粗竹筷在药粉内成圆周搅动，边倒步骤二熬炼的蜂蜜边调药粉，以基本上看不到药粉时停止加蜜，调好后，用消毒的双手在盆中和为药团；
步骤四、搓条、和丸，和丸时用少许芝麻油、点掌心以使药丸光亮；
步骤五、包装：将药丸晒干或红外线灯烤干，用无毒瓶密储干燥阴凉处。
本中药组合物服用方法为：1次9克，1天2次，20天为1疗程。
实施例1：
一种气虚型体质健脾益气、养血止痒的中药组合物由下述重量份的药材配制而成：党参10份，焦白术10份，茯苓10份，山药10份，焦扁豆10份，炙黄芪200份，制首乌10份，熟地黄100份，当归10份，大白芍10份，山萸肉10份，金樱子10份，制黄精10份，枸杞子10份，女贞子10份，旱莲草100份，丹参20份，川芎10份，仙鹤草100份，肥玉竹10份，知母10份，鸡内金10份，桔梗10份，姜半夏10份，陈皮10份，夜交藤5份，酸枣仁10份，柏子仁10份，白鲜皮10份，防风10份，火麻仁10份，大腹皮10份，瓜蒌皮10份，焦山楂10份，焦六曲10份，生甘草5份，淮小麦100份，大枣100份，生晒参5份，西洋参5份。
实施例2：
一种气虚型体质健脾益气、养血止痒的中药组合物由下述重量份的药材配制而成：党参150份，焦白术150份，茯苓150份，山药150份，焦扁豆150份，炙黄芪300份，制首乌150份，熟地黄200份，当归120份，大白芍150份，山萸肉90份，金樱子900份，制黄精120份，枸杞子120份，女贞子100份，旱莲草300份，丹参200份，川芎90份，仙鹤草300份，肥玉竹120份，知母90份，鸡内金120份，桔梗90份，姜半夏90份，陈皮90份，夜交藤30份，酸枣仁90份，柏子仁90份，白鲜皮150份，防风90份，火麻仁90份，大腹皮90份，瓜蒌皮150份，焦山楂120份，焦六曲150份，生甘草30份，淮小麦200份，大枣200份，生晒参50份，西洋参50份。
实施例3：
一种气虚型体质健脾益气、养血止痒的中药组合物由下述重量份的药材配制而成：党参120份，焦白术120份，茯苓120份，山药120份，焦扁豆120份，炙黄芪150份，制首乌120份，熟地黄150份，当归80份，大白芍120份，山萸肉70份，金樱子600份，制黄精80份，枸杞子80份，女贞子80份，旱莲草200份，丹参100份，川芎80份，仙鹤草200份，肥玉竹80份，知母80份，鸡内金100份，桔梗80份，姜半夏80份，陈皮80份，夜交藤25份，酸枣仁70份，柏子仁70份，白鲜皮120份，防风80份，火麻仁80份，大腹皮80份，瓜蒌皮120份，焦山楂100份，焦六曲120份，生甘草20份，淮小麦150份，大枣150份，生晒参35份，西洋参35份。
疗效检测方法
一般资料：选取2018年1月～2019年1月在皮肤科门诊就诊的患者共2000例。平均年龄62岁。本组入选病例标准：①皮肤瘙痒发生于老年人年龄55岁以上；②没有原发性皮疹；③可以继发抓痕，血痂，甚至苔癣化，色素沉着。病程最短1个月，最长6年。
将所有患者随机分为实验组1、实验组2、实验组3、对照组。三组患者在年龄、性别、发病时间、既往健康史、一般情况等方面无统计学差异(P＞0.05)具有可比性。
2、治疗方法：实验组1、实验组2、实验组3服用本发明药物；
3、对照组1患者采皮肤科常规药物治疗，口服盐酸酮替芬，每日2次口服，每次剂量1mg；服药期间禁食辛辣刺激性食物，避免日光浴。
4、疗效标准：参照《实用中西医结合诊断治疗学》皮肤瘙痒症疗效标准。①治愈：瘙痒及皮肤继发损害抓痕、血痂、皮肤粗糙消失；②显效：无明显瘙痒，继发性皮损消退80％以上；③无效：瘙痒无减轻，继发皮损消退不足20％，治疗期间仍有加重。
表1
治疗后实施例1、实施例2和实施例3半年后症状全部消失，且无复发。
对比例半年后有一半复发，由此可见本发明中药组合物对气血两虚之皮肤干燥瘙痒患者具有较好的疗效。
案型病例：
李某，男，65岁，主诉：全身皮肤瘙痒不适近2年。经血常规、生化、肝功、血脂、血糖、胸片、腹部B超等检查后都未见异常。查体：全身未见明显皮疹，皮肤干燥，可见大量散在抓痕、血痂，部分皮肤呈苔癣样变，颈部、腋窝、腹股沟等浅表淋巴结未触及明显肿大。经中西医治疗15天后后瘙痒减轻，全身未见新有抓痕、血痂，治疗3个疗程后瘙痒完全消除。
柯某，男，70岁，患者全身皮肤瘙痒，反复发作十多年，患者十年前冬季起病，其后反复发作，皮肤瘙痒，夜痒难眠，头晕乏力，时有便溏，曾服各种抗组胺药物无效。伴冠心病，夜眠多梦，舌淡红，苔少，脉濡涩，服用本方一个月后瘙痒止，未再发疹，再服用两月后，舌苔红，苔薄，脉濡细，痊愈。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。

Claims (3)

1.一种气虚型体质健脾益气、养血止痒的中药组合物，其特征在于：所述的中药组合物由下述重量份的药材配制而成：党参10-150份，焦白术10-150份，茯苓10-150份，山药10-150份，焦扁豆10-150份，炙黄芪200-300，制首乌10-150份，熟地黄100-200份，当归10-120份，大白芍10-150份，山萸肉10-90份，金樱子10-900份，制黄精10-120份，枸杞子10-120份，女贞子10-100份，旱莲草100-300份，丹参20-200份，川芎10-90份，仙鹤草100-300份，肥玉竹10-120份，知母10-90份，鸡内金10-120份，桔梗10-90份姜半夏10-90份，陈皮10-90份，夜交藤5-30份，酸枣仁10-90份，柏子仁10-90份，白鲜皮10-150份，防风10-90份，火麻仁10-90份，大腹皮10-90份，瓜蒌皮10-150份，焦山楂10-120份，焦六曲10-150份，生甘草5-30份，淮小麦100-200份，大枣100-200份，生晒参5-50份，西洋参5-50份。
2.根据权利要求1所述的一种气虚型体质健脾益气、养血止痒的中药组合物，其特征在于：所述的中药组合物由下述重量份的药材配制而成：党参120份，焦白术120份，茯苓120份，山药120份，焦扁豆120份，炙黄芪150份，制首乌120份，熟地黄150份，当归80份，大白芍120份，山萸肉70份，金樱子600份，制黄精80份，枸杞子80份，女贞子80份，旱莲草200份，丹参100份，川芎80份，仙鹤草200份，肥玉竹80份，知母80份，鸡内金100份，桔梗80份，姜半夏80份，陈皮80份，夜交藤25份，酸枣仁70份，柏子仁70份，白鲜皮120份，防风80份，火麻仁80份，大腹皮80份，瓜蒌皮120份，焦山楂100份，焦六曲120份，生甘草20份，淮小麦150份，大枣150份，生晒参35份，西洋参35份。
3.一种气虚型体质健脾益气、养血止痒的中药组合物的制备方法，其特征在于：具体制备方法为：步骤一、将中药组合物按照重量份原料配比，将党参，焦白术，茯苓，山药，焦扁豆，炙黄芪，制首乌，熟地黄，当归，大白芍，山萸肉，金樱子，制黄精，枸杞子，女贞子，旱莲草，丹参，川芎，仙鹤草，肥玉竹，知母，鸡内金，桔梗，姜半夏，陈皮，夜交藤，酸枣仁，柏子仁，白鲜皮，防风，火麻仁，大腹皮，瓜蒌皮，焦山楂，焦六曲，生甘草，淮小麦，大枣，生晒参，西洋参全部粉碎成粉末，将粉碎的药材粉末全部投入超临界流体萃取反应釜中，然后加入改性剂乙醇0.3ml，萃取条件为压力34.5mPa，温度60℃，静态萃取时间10min，动态萃取量10ml，以水作为吸引，得到纯度很高的药粉；
步骤二、炼蜜，熬炼蜂蜜，先用武火，熬沸腾后改为文火缓熬；
步骤三、调药，将熬炼好的蜂蜜用勺子倒入步骤一制备的药粉内，同时用粗竹筷在药粉内成圆周搅动，边倒步骤二熬炼的蜂蜜边调药粉，以基本上看不到药粉时停止加蜜，调好后，用消毒的双手在盆中和为药团；
步骤四、搓条、和丸，和丸时用少许芝麻油、点掌心以使药丸光亮；
步骤五、包装：将药丸晒干或红外线灯烤干，用无毒瓶密储干燥阴凉处。
CN201910836729.5A 2019-09-05 2019-09-05 一种气虚型体质健脾益气、养血止痒的中药组合物 Withdrawn CN110420296A (zh)

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