CN110420244A - A kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule - Google Patents
A kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule Download PDFInfo
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The present invention relates to a kind of preparation methods with calming soporific, anti-inflammatory analgetic pet soft capsule.The soft capsule is made of capsule skin and capsule 's content, wherein every part of capsule liquid is made of the raw material of following weight percent: 1%~10% industrial hemp composes oil, 15%~45% fish oil, 0.5%~1% vitamin D oil, 0.5%~5% vitamin E oil entirely, and surplus is fiery sesame oil；Every part of capsule skin is made of medical gelatin, purified water, glycerol according to 1:0.5~2:0.2~1, by weight.Industrial hemp composes oil cannboid and terpene phenol containing there are many entirely in the present invention, has protection nerve, antianxiety, calming soporific and other effects；Fiery sesame oil contains antioxidant, vitamin E can be cooperateed with to play anti-oxidation function, so that fish oil be avoided to be oxidized；Fiery sesame oil and fish oil unsaturated fatty acid rich in have the effect for resisting inflammation, and this product prescription compatibility is preferable, has preferable health-care efficacy to pet.
Description
Technical field
The invention belongs to pet care product technical fields, and in particular to one kind has effects that calming soporific, anti-inflammatory analgetic are doted on
The preparation method of composition soft capsule.
Background technique
According to conservative estimation, China a minimum of pet 100,000,000 at present, the market potential of pets economy may be up to 15,000,000,000 or more,
And in lasting ascendant trend.No matter the elderly or young man, pet can bring joy to them, relieve stress and eliminate
Sense tired out, pet play an increasingly important role in the family.Pet care product are formulated according to the physiological status of pet
Nutrition recuperating product, be conducive to the healthy development and growth of pet, while it is extensive for illness pet also to can be used as adjuvant treatment
It is multiple.
It is the Chinese fried dough twist leaf extract without further isolating and purifying that industrial hemp composes oil entirely, all containing industrial hemp
Ingredient, including terpenes, cannboid, flavone compound and fatty acid etc., all these substances have the medical valence of itself
Value, helps to create so-called retinue's response to treatment.Wherein, main active cannabidiol (CBD) has guarantor in cannboid
Protect nerve effect, it is no additive and have anti-spasm, antirheumatic arthritis and effect antianxity.The study found that the mankind are big
GABA neurotransmitter in brain has sedation effect, inhibits the excitability of brain centres, and cannabidiol can help to control GABA mind
Consumption through mediator inhibits brain excitement, reduces epileptic attack, may also help in the curative effect for improving other antiepileptics.
Currently, in the world multiple studies have shown that: insomnia can be effectively relieved in cannabidiol (CBD).SaoPaulo State,Brazil in 1981
One studies have shown that CBD may be due to its angst resistance effect, to prevent the duration REM sleep induced by anxiety.This
Outside, cannabidiol can play analgesic and anti-inflammatory effect by the double inhibition to cyclooxygenase and lipoxygenase, and effect is strong
Known to the people and the aspirin of extensive utilization.
Fiery sesame oil is the oily mixture that fructus cannabis is extracted by techniques such as low-temperature cold pressing, subcritical low-temperature extractions.Fire
Flaxseed oil is full of nutrition, contains antioxidant, protein, carrotene, phytosterol, phosphatide and several mineral materials and abundant
Unsaturated fatty acid has anti-inflammatory, anti-aging, processing skin infection, helps to cure skin injury and anti-oxidation efficacy.
Fish oil is a kind of grease extracted from greasiness fish, is rich in eicosapentaenoic acid (EPA) and two dodecahexaenes
Acid (DHA) a variety of ω -3 are polyunsaturated fatty acid, natural omega-3 unsaturated fatty acid, are indispensable in a kind of pet body
It is few but cannot oneself generate essential fatty acid.The rate of metabolism of body can be improved, so pet is taking ω -3
Afterwards, skin, hair quality, constitution have extremely apparent improvement and raising.In addition, ω -3 also has excellent anti-inflammatory effect, and
There is no many side effects of anti-inflammatory drug, therefore referred to as most effective natural anti-inflammatory medicine.And compared to plant origin
ω -3 is easy by body conversion, therefore is become to supplement the first choice of ω -3, but fish oil is easy to oxidize.
Industrial hemp composes oil cannboid and terpene phenol containing there are many entirely, can be with main active-cannabidiol in full spectrum oil
(CBD) synergistic effect is played, there is protection nerve, antianxiety, calming soporific and other effects；Fiery sesame oil contains antioxidant, can be with
Vitamin E is cooperateed with to play anti-oxidation function, so that fish oil be avoided to be oxidized；Fiery sesame oil and fish oil unsaturated lipid rich in
Fat acid has the effect for resisting inflammation, plays the role of preferable anti-inflammatory analgetic, calming soporific after pets, can assist in the treatment of class
Rheumatic arthritis, and pet immunity of organisms can be improved, multivitamin is supplemented, is had obviously to skin, the hair of pet
Improvement.
Summary of the invention
Relatively lack for the pet care product currently on the market with calming soporific, anti-inflammatory analgetic, mesh of the invention
Be prepare it is a containing active skull cap components, formula is simple and the apparent pet soft capsule of effect.The prescription compatibility of this product
Property it is preferable, industrial hemp composes oil entirely to play synergistic effect with main active-cannabidiol (CBD) in full spectrum oil, have
The effect of protecting nerve, antianxiety, calming soporific；Fiery sesame oil contains antioxidant, and vitamin E can be cooperateed with to play anti-oxidant function
Can, so that fish oil be avoided to be oxidized；Fiery sesame oil and fish oil unsaturated fatty acid rich in have the effect for resisting inflammation,
Comprehensive various composition, makes this product have the effect of preferable calming soporific, anti-inflammatory analgetic, and can improve pet immunity of organisms,
There is preferable health-care efficacy to pet.
The specific steps of the present invention are as follows:
(1) preparation of interior feed liquid
By weight percentage by 1%~10% industrial hemp compose full oil, 15%~45% fish oil, 0.5%~1% vitamin D oil, 0.5%~
5% vitamin E oil, surplus are fiery sesame oil, and the above ingredient is uniformly mixed, and are filtered to get feed liquid in soft capsule, spare.
(2) preparation of gelatin solution
Gelatin, purified water, glycerol are added sequentially in flask with the ratio of 1:0.5~2:0.2~1 in formula, heating stirring is molten
Solution；Dissolved gelatin mixed liquor is filtered, vacuum outgas；Slow breaking vacuum after degassing filters glue again；
Then glue is kept the temperature spare.
(3) pelleting
Rubber is made in glue after the heat preservation, feed liquid in soft capsule, compacting are filled under conditions of certain temperature and humidity
At soft capsule.
(4) dryness finalization
By the just soft capsule processed soft capsule sizing drying machine dryness finalization；After being formed, capsule is cleaned with ethyl alcohol, it is dry,
Soft capsule is made.
Step (1) filtering uses 50~200 mesh filter clothes.
Step (2) heating temperature is 60~90 DEG C, vacuum outgas -0.08~-0.1MPa of vacuum degree, temperature 60 C；
12~36h is kept the temperature at 30~70 DEG C.
The step (3) carries out in soft capsule pellet press, glue and content is placed in pellet press, capsule skin thickness
In 0.4~0.5mm, controlling content loading amount is 0.3~0.5g/ for control, and room temperature is controlled at 18~30 DEG C, relative humidity 25
~40%.
Step (4) setting temperature is 18~30 DEG C, and relative humidity is 25~40%, 3~6h of setting time；Ethyl alcohol is dense
Degree 70~95%, at 25~40 DEG C, under conditions of relative humidity is 25~40%, dry 12~48h.
Beneficial effects of the present invention:
1, industrial hemp composes oil containing there are many active constituents for having medical value, including terpenes, cannboid, flavone compound entirely
With fatty acid etc., these substances help to create so-called retinue's response to treatment, than cannabidiol sterling effect is used alone more
It is good.
2, fiery sesame oil and industrial hemp compose oil entirely and belong to industrial hemp converted products, and synergistic effect is good, can give full play to guarantor
The effect of protecting nerve, antianxiety, calming soporific；Fiery sesame oil and vitamin E have stronger anti-oxidation characteristics, can be to avoid fish oil quilt
Oxidation；Fish oil and fiery sesame oil are rich in omega-3 unsaturated fatty acid, there is preferable antiphlogistic effects.
3, soft capsule ingredient of the present invention is simple, and compatibility is preferable, is animals and plants active skull cap components, takes safety for a long time
It is without side-effects, have the effect of preferable calming soporific, anti-inflammatory analgetic, can adjuvant therapy rheumatoid arthritis, and can improve and dote on
Object immunity of organisms supplements multivitamin, improves pet skin and hair quality.
Specific embodiment
With reference to embodiments, the present invention will be described in further detail.(by feed liquid in 1kg soft capsule, 1kg gelatin
Liquid calculates)
Embodiment 1
1) preparation of feed liquid in
10g industrial hemp is composed into oil, 5g vitamine D3 acetate, 5g Vitwas E, 830g fire sesame oil, 150g fish oil entirely
It is mixed evenly to get feed liquid in soft capsule, it is spare.
2) preparation of gelatin solution
400g gelatin, 400g purified water, 200g glycerol are added sequentially in flask, be heated to 75 DEG C and are stirred continuously to complete
Dissolution, is made gelatin mixed liquor；By 100 mesh filter-cloth filtering of gelatin mixed liquor, filtrate is in vacuum degree -0.08MPa, and 60.0 DEG C of temperature
Under the conditions of, stirring to solution bubble-free is released；Slow breaking vacuum, gained gelatin solution carry out 100 mesh filter-cloth filterings again；Filtrate
14 hours are kept the temperature under the conditions of being placed in 60 DEG C, it is spare.
3) pelleting
Interior feed liquid and gelatin solution made from step 1) and step 2 are placed in soft capsule pellet press, discharging speed, control are adjusted
Interior feed liquid loading amount is 0.4g/, and at 22 DEG C, relative humidity is controlled 35% for room temperature control.
4) dryness finalization
By step 3), just soft capsule processed is fixed under conditions of temperature is 22 DEG C, relative humidity is 35% with soft capsule sizing drying machine
Type 3.5 hours, soft capsule surface was cleaned with the ethanol solution of mass fraction 95%；At 26 DEG C, condition that relative humidity is 25%
Under, dry 30h.Soft capsule is made.
Embodiment 2
1) preparation of feed liquid in
50g industrial hemp is composed into oil, 5g vitamine D3 acetate, 5g 25(OH)VD 3,20g VE succinic acid entirely
Ester, 700g fire sesame oil, 220g fish oil are mixed evenly to get feed liquid in soft capsule, spare.
2) preparation of gelatin solution
500g gelatin, 300g purified water, 200g glycerol are added sequentially in flask, be heated to 75 DEG C and are stirred continuously to complete
Dissolution, is made gelatin mixed liquor；By 100 mesh filter-cloth filtering of gelatin mixed liquor, filtrate is in vacuum degree -0.08MPa, and 60.0 DEG C of temperature
Under the conditions of, stirring to solution bubble-free is released；Slow breaking vacuum, gained gelatin solution carry out 100 mesh filter-cloth filterings again；Filtrate
14 hours are kept the temperature under the conditions of being placed in 60 DEG C, it is spare.
3) pelleting
Interior feed liquid and gelatin solution made from step 1) and step 2 are placed in soft capsule pellet press, discharging speed, control are adjusted
Interior feed liquid loading amount is 0.4g/, and at 22 DEG C, relative humidity is controlled 35% for room temperature control.
4) dryness finalization
By step 3), just soft capsule processed is fixed under conditions of temperature is 22 DEG C, relative humidity is 35% with soft capsule sizing drying machine
Type 3.5 hours, soft capsule surface was cleaned with the ethanol solution of mass fraction 95%；At 26 DEG C, condition that relative humidity is 25%
Under, dry 30h.Soft capsule is made.
Embodiment 3
1) preparation of feed liquid in
100g industrial hemp is composed into oil, 10g 25(OH)VD 3,20g Vitamin E succinate, 30g vitamin E niacin entirely
Ester, 540g fire sesame oil, 300g fish oil are mixed evenly to get feed liquid in soft capsule, spare.
2) preparation of gelatin solution
425g gelatin, 400g purified water, 175g glycerol are added sequentially in flask, be heated to 75 DEG C and are stirred continuously to complete
Dissolution, is made gelatin mixed liquor；By 100 mesh filter-cloth filtering of gelatin mixed liquor, filtrate is in vacuum degree -0.08MPa, and 60.0 DEG C of temperature
Under the conditions of, stirring to solution bubble-free is released；Slow breaking vacuum, gained gelatin solution carry out 100 mesh filter-cloth filterings again；Filtrate
14 hours are kept the temperature under the conditions of being placed in 60 DEG C, it is spare.
3) pelleting
Interior feed liquid and gelatin solution made from step 1) and step 2 are placed in soft capsule pellet press, discharging speed, control are adjusted
Interior feed liquid loading amount is 0.5g/, and at 22 DEG C, relative humidity is controlled 35% for room temperature control.
4) dryness finalization
By step 3), just soft capsule processed is fixed under conditions of temperature is 22 DEG C, relative humidity is 35% with soft capsule sizing drying machine
Type 3.5 hours, soft capsule surface was cleaned with the ethanol solution of mass fraction 95%；At 26 DEG C, condition that relative humidity is 25%
Under, dry 30h.Soft capsule is made.
Embodiment 4
1) preparation of feed liquid in
70g industrial hemp is composed into oil, 10g vitamine D3 acetate, 20g Vitamin E succinate, 20g vitamin E acetic acid entirely
Ester, 490g fire sesame oil, 400g fish oil are mixed evenly to get feed liquid in soft capsule, spare.
2) preparation of gelatin solution
400g gelatin, 400g purified water, 200g glycerol are added sequentially in flask, be heated to 75 DEG C and are stirred continuously to complete
Dissolution, is made gelatin mixed liquor；By 100 mesh filter-cloth filtering of gelatin mixed liquor, filtrate is in vacuum degree -0.08MPa, and 60.0 DEG C of temperature
Under the conditions of, stirring to solution bubble-free is released；Slow breaking vacuum, gained gelatin solution carry out 100 mesh filter-cloth filterings again；Filtrate
14 hours are kept the temperature under the conditions of being placed in 60 DEG C, it is spare.
3) pelleting
Interior feed liquid and gelatin solution made from step 1) and step 2 are placed in soft capsule pellet press, discharging speed, control are adjusted
Interior feed liquid loading amount is 0.5g/, and at 22 DEG C, relative humidity is controlled 35% for room temperature control.
4) dryness finalization
By step 3), just soft capsule processed is fixed under conditions of temperature is 22 DEG C, relative humidity is 35% with soft capsule sizing drying machine
Type 3.5 hours, soft capsule surface was cleaned with the ethanol solution of mass fraction 95%；At 26 DEG C, condition that relative humidity is 25%
Under, dry 30h.Soft capsule is made.
Above embodiments are only the explanations that makes an explanation to the present invention, do not carry out any limit to protection scope of the present invention
System.To those skilled in the art, all to exist without departing from same embodiment or change made by the technology of the present invention spirit
Within protection scope of the present invention.
Claims (9)
1. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule, which is characterized in that including walking as follows
It is rapid:
Step 1, the preparation of interior feed liquid
Industrial hemp is composed to oil, fiery sesame oil, fish oil, vitamin D oil, vitamin E oil entirely to be uniformly mixed according to a certain percentage, mistake
Filter is spare to get feed liquid in soft capsule；
Step 2, the preparation of gelatin solution
Medical gelatin, purified water, glycerol are added sequentially in flask by formula, heating stirring dissolution；By dissolved gelatin
Mixed liquor filtering, vacuum outgas；Slow breaking vacuum after degassing filters glue again；Then glue is kept the temperature standby
With；
Step 3, pelleting
Rubber is made in glue after the heat preservation, feed liquid in soft capsule, compacting are filled under conditions of certain temperature and humidity
At soft capsule；
Step 4, dryness finalization
By the just soft capsule processed soft capsule sizing drying machine dryness finalization；After being formed, capsule is cleaned with ethyl alcohol, it is dry,
Soft capsule is made.
2. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule according to claim 1,
It is characterized in that, in the step 1, interior feed liquid includes that 1%~10% industrial hemp composes oil, 15%~45% fish oil, 0.5%~1% dimension entirely
Raw element D oil, 0.5%~5% vitamin E oil, surplus are fiery sesame oil.
3. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule according to claim 1,
It is characterized in that, in the step 1, vitamin D is selected from one or more of vitamine D3 acetate, 25(OH)VD 3 group
It closes.
4. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule according to claim 1,
It is characterized in that, in the step 1, the vitamin E is selected from Vitwas E, Vitamin E succinate, vitamin E niacin
The combination of one or more of ester.
5. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule according to claim 1,
It is characterized in that, in the step 1, industrial hemp composes cannabidiol content in oil entirely and is not less than 50%.
6. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule according to claim 1,
It is characterized in that, in the step 1, filtering uses 50~200 mesh filter clothes.
7. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule according to claim 1,
It is characterized in that, in the step 2, gelatin, purified water, the ratio of glycerol are 1:0.5~2:0.2~1；Heating temperature is 60~90
DEG C, 100~500r/min of speed of agitator, vacuum outgas -0.08~-0.1MPa of vacuum degree, temperature 60 C；At 30~70 DEG C of glue
Keep the temperature 12~36h.
8. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule according to claim 1,
It is characterized in that, in the step 3, pelleting carries out in soft capsule pellet press；Capsule skin is about 0.4~0.5mm or so；In capsule
Feed liquid loadings are 0.3~0.5g/；Environmental condition is that room temperature is controlled at 18~30 DEG C, and relative humidity is 25~40%.
9. a kind of preparation method with calming soporific, anti-inflammatory analgetic pet soft capsule according to claim 1,
It is characterized in that, in the step 4, setting temperature is 18~30 DEG C, and relative humidity is 25~40%, 3~6h of setting time；Cleaning
Capsule concentration of alcohol is 70~95%；Drying condition is under conditions of relative humidity is 25~40%, to dry at 25~40 DEG C
12~48h.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113750072A (en) * | 2021-08-24 | 2021-12-07 | 云南省工业大麻产业投资有限公司 | CBD full spectrum oil (or broad spectrum oil) soft capsule formula and processing method |
-
2019
- 2019-09-02 CN CN201910821071.0A patent/CN110420244A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113750072A (en) * | 2021-08-24 | 2021-12-07 | 云南省工业大麻产业投资有限公司 | CBD full spectrum oil (or broad spectrum oil) soft capsule formula and processing method |
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