CN110420194A - A kind of condensed pill preparation process - Google Patents
A kind of condensed pill preparation process Download PDFInfo
- Publication number
- CN110420194A CN110420194A CN201910617072.3A CN201910617072A CN110420194A CN 110420194 A CN110420194 A CN 110420194A CN 201910617072 A CN201910617072 A CN 201910617072A CN 110420194 A CN110420194 A CN 110420194A
- Authority
- CN
- China
- Prior art keywords
- powder
- fried
- medicinal material
- preparation process
- pill preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of condensed pill preparation processes, are related to condensed pill preparation technical field comprising following steps: S1, medicinal material configuration；S2, powder pulverizing medicinal materials processed；S3, medicinal material are fried；S4, medical fluid concentration；S5, softwood is prepared；S6, granulation operation；S7, whole grain operation；S8, powder are dry.The present invention helps to ensure that the perfectly round property of powder, and the advantages of help to ensure that the aesthetics of powder.
Description
Technical field
The present invention relates to condensed pill preparation technical fields, more particularly, to a kind of condensed pill preparation process.
Background technique
Condensed pill means that the decocting liquid of drug or some drugs or extraction are condensed into medicinal extract, with suitable auxiliary material or fine drug powder
Manufactured pill.It has many advantages, such as it is small in size, convenient for taking.
Existing invention patent mandate notification number is the Chinese patent of CN102133239B, it discloses a kind of medicine pill and
Preparation method, including the preparation method of traditional Chinese drug inspissation ball, blood-nourishing and brain-refreshing extract dry powder is ground into fine powder by (1), sieves powder；
(2) microcrystalline cellulose or/and powdered cellulose, polyethylene glycol-6000 are ground into fine powder, sieve powder；(3) by above-mentioned (1), (2)
In fine powder be uniformly mixed；(4) mixed material that step (3) generate is squeezed or is heated extruding, form medicine and stick together；(5) medicine
Stick together be made with the matched medicinal strip of drug specifications, twist pelletization；(6) coating of pill made of.
In the production of actual condensed pill, staff often sticks together progress into item and stranding ball to medicine using full automatic machine for producing pills
Operation.However, using pill made of pellet processing machine, surface often has more pit, sternly due to pellet processing machine defect itself
Ghost image rings the aesthetics of condensed pill appearance, and there are places to be modified.
Summary of the invention
In view of the above technical problems, present invention aims at a kind of condensed pill preparation process is proposed, by being carried out to powder
Whole grain operation, and whole grain powder is served as by spare dry powder, thus help to ensure that the perfectly round property of powder, and help to ensure that powder
Aesthetics.
Above-mentioned technical purpose of the invention has the technical scheme that a kind of condensed pill preparation process,
Include the following steps: S1, medicinal material configuration: various medicinal materials weigh by staff and are taken, and are separated according to quantity from medicinal material
Fried medicinal material and powder medicinal material processed, and fried medicinal material is packed into fried medicine bag；S2, powder pulverizing medicinal materials processed: powder is carried out to powder medicinal material processed
It is broken, and it is screened obtain thinner medicinal powder, and medicinal powder is separated to mixed powder and spare dry powder according to quantity；S3, medicinal material are fried: will decoct
In pharmacy bag and fried medicinal material merging decocting pot, and it is fried to fill the water progress；S4, medical fluid concentration: it after medicinal material is fried, will decoct
Pharmacy bag and fried medicinal material take out, and continue to heat to the medical fluid in decocting pot, are concentrated, stopping pair after the completion of concentration
Decocting pot is heated；S5, it prepares softwood: mixed powder is placed in decocting pot and mixed with the concentrated medicament in decocting pot
It closes, and by stirring to get softwood；S6, granulation operation: it by softwood item obtained and rubs ball with the hands, powder is made；S7, whole grain are made
Industry: powder being placed in coating pan, and is gradually added spare dry powder in coating pan operational process, and simultaneously to spraying in coating pan
Enter to bond liquid；S8, powder are dry: powder being put into drying box and is dried, finished product powder is obtained.
By using above-mentioned technical proposal, in real work, spare dry powder is reserved in step s 2, and in step s3 will
Backup dry powder is gradually added into coating pan with the operation of coating pan, and simultaneously to penetrating bonding liquid in coating pan.Pass through
This mode helps to ensure that the perfectly round property of powder, guarantees the aesthetics of powder, and reduce being mixed into for useless material, facilitate
Guarantee the pharmacological property of powder.
The present invention is further arranged to: S9, powder coating: powder being placed in coating pan again, is coated to powder
Processing.
By using above-mentioned technical proposal, finished product powder is coated again, is further ensured that the beauty of powder, and had
Help reduce powder flavour of a drug distribute with part drug effect scatter and disappear.
The present invention is further arranged to: before step S1, prescription is analyzed, choose wherein simply content of starch compared with
More medicinal materials is adjutant；In step sl, adjutant is individually separated；In step s 2, adjutant is smashed, obtains coating powder；
In step s 9, as coating powder is gradually placed in coating pan by the operating of coating pan.
By using above-mentioned technical proposal, in real work, by the more medicinal material of content of starch is selected as helping simply in prescription
Medicine, and coating powder is made；Then, coating powder is gradually placed in coating pan by the operating of coating pan.In this way, facilitate
It is further reduced powder flavour of a drug and distributes and scatter and disappear with part drug effect, and reduce being mixed into for useless material, help to ensure that powder
Pharmacological property.
The present invention is further arranged to: in S3, decocting pot is tilting-type steam double boiler, and liquid boils in decocting pot
Afterwards, then constant temperature cooks 1-2 hours.
By using above-mentioned technical proposal, on the one hand, use tilting-type steam double boiler, facilitate staff to medicinal material
The control operation of heating operation and temperature, and staff is facilitated to take out operation, to the cleaning work of decocting pot to subsequent softwood
Industry；On the other hand, by after liquid boils in decocting pot, then constant temperature cooks 1-2 hours, helps to ensure that fried to medicinal material abundant
Property.
The present invention is further arranged to: in step s3, during medicinal material is fried, decocting pot is in closed state.
By using above-mentioned technical proposal, decocting pot is closed during medicinal material is fried, facilitates the stream for reducing drug effect
It loses.
The present invention is further arranged to: in S4, carrying out controlling operation to the medical fluid in fried medicine bag by strainer, and make
The medical fluid that must be controlled out is instilled into decocting pot, while the mode that pressing can be used squeezes out the medical fluid in fried medicine bag.
By using above-mentioned technical proposal, the medical fluid control in fried medicine bag is gone out and is extruded, medicinal material drug effect is further reduced
Loss, help to ensure that the drug effect of final powder.
The present invention is further arranged to: in S6, be sieved to powder, mesh density according to powder customize size and
Determine, and the larger powder screened out is back to softwood, again pill.
By using above-mentioned technical proposal, on the one hand, powder is sieved, helps to ensure that powder is uniform in size, guarantees disease
The precision of people's dose；On the other hand, the powder produced in granulation operation is wet grain, and the powder screened out directly returns to softwood weight
New pill helps to reduce the waste to medicinal material, save the cost.
The present invention is further arranged to: in step s 6, spare dry powder being sprinkled upon on the softwood rubbed with the hands in grain operation.
By using above-mentioned technical proposal, spare dry powder is sprinkled upon on the softwood rubbed with the hands in grain operation, is put to reduce powder
Glutinous situation is glued when setting to occur.
The present invention is further arranged to: in the step s 7, being blown by hair dryer into the coating pan of operation.
It by using above-mentioned technical proposal, is blown from hair dryer into the coating pan of operation, helps to reduce whole grain operation
Middle powder is glued glutinous situation and is occurred.
The present invention is further arranged to: in step s 8, drying box temperature is maintained at 60-70 degrees Celsius, and powder is dry
It is 10 hours dry in dry case.
By using above-mentioned technical proposal, drying box is maintained at 60-70 degrees Celsius, so that it is excessively high to facilitate reduction temperature
The case where causing powder face checking generation reduces the situation that powder goes bad at high operating temperatures and occurs.
Compared with prior art, beneficial effects of the present invention are as follows:
(1) by carrying out whole grain operation to powder, and whole grain powder is served as by spare dry powder, thus helps to ensure that the perfectly round of powder
Property, and help to ensure that the aesthetics of powder；
(2) by the way that spare dry powder is served as whole grain powder, high-ranking officer's medicinal powder is broken to obtain coating powder, and coating is applied to the packet to powder
In clothing operation, being mixed into for useless material is reduced, helps to ensure that the pharmacological property of powder；
(3) it is cooked 1-2 hours by the way that medicinal material is boiled rear constant temperature, and closes decocting pot during medicinal material is fried, and to pan-fried
Medical fluid in pharmacy bag carries out controlling operation, reduces the loss of medicinal material drug effect, helps to ensure that the drug effect of final powder；
(4) it by the way that spare dry powder to be sprinkled upon on the softwood rubbed with the hands in grain operation, and is blown by hair dryer into the coating pan of operation,
Glutinous situation generation is glued between powder to reduce；
(5) it by carrying out controlling operation to the medical fluid in fried medicine bag, and is sieved to wet grain, and the larger medicine that will be screened out
Grain is back to softwood pill again, helps to reduce the waste to medicinal material, save the cost.
Detailed description of the invention
Fig. 1 is the flow diagram of the present embodiment major embodiment condensed pill preparation process.
Specific embodiment
Below with reference to examples and drawings, the present invention is described in further detail, but embodiments of the present invention are not only
It is limited to this.
Embodiment one:
Referring to attached drawing 1, a kind of condensed pill preparation process includes the following steps:
Prescription analysis before producing: analyzing prescription, and choosing wherein the more medicinal material of content of starch simply is adjutant.
S1, medicinal material configuration: various medicinal materials weigh by staff and are taken, are separated according to quantity from the medicinal material taken pan-fried
Pharmacy material and powder medicinal material processed, and fried medicinal material is packed into fried medicine bag；Meanwhile part adjutant is individually taken out from medicinal material.
S2, powder pulverizing medicinal materials processed: crushing powder medicinal material processed, screened to obtain thinner medicinal powder, and according to quantity by medicinal powder
Separate mixed powder and spare dry powder；Meanwhile adjutant is crushed, it is screened to obtain thinner coating powder.Wherein, medicine is mixed
Powder, spare dry powder and coating powder cross 100-110 mesh, by sieve from larger particles powder return and crush again.
S3, medicinal material are fried: fried medicine bag and fried medicinal material being placed in decocting pot, and it is fried to fill the water progress；Specifically,
Decocting pot is tilting-type steam double boiler, and after liquid boils in decocting pot, then constant temperature cooks 1-2 hours；Meanwhile the fried mistake of medicinal material
Cheng Zhong, decocting pot keep closed state.
S4, medical fluid concentration: after medicinal material is fried, staff can first be taken fried medicine bag and fried medicinal material
Out, the medical fluid in fried medicine bag is carried out by strainer controlling operation, and the medical fluid controlled out is instilled into decocting pot；Together
When, the medical fluid in fried medicine bag can be squeezed out by the way of pressing；Then, the medical fluid in decocting pot is continued to heat,
It is concentrated, medical fluid concentration is become into the ointment that 80-100 degrees Celsius of measured value is relative density 1.3-1.4, measuring tool can be with
It is densitometer, stops heating decocting pot after the completion of concentration；
S5, it prepares softwood: mixed powder is placed in decocting pot and mixed with the concentrated medicament in decocting pot, and by stirring
It mixes to obtain softwood；
S6, granulation operation: it by softwood item obtained and rubs ball with the hands, powder is made；Specifically, can by full automatic machine for producing pills into
Row granulation.Meanwhile spare dry powder obtained in S2 being sprinkled upon on the softwood rubbed with the hands in grain operation, it is viscous glutinous to reduce the powder in wet shape
The case where occur.
S6.1, it is sieved in the powder of wet shape, depending on mesh density customizes size according to powder, and will screen out
Larger powder is back to softwood, again pill.
S7, whole grain operation: powder being placed in coating pan, and is gradually added spare dry powder in coating pan operational process,
And simultaneously to bonding liquid is sprayed into coating pan, bonding liquid can be water, be also possible to yellow rice wine；Meanwhile by hair dryer to
It blows in the coating pan of operation, air blowing separation is carried out to pill, reduce to glue sticking between powder.Wherein, when bonding liquid uses Huang
When wine, yellow rice wine has the effect of promoting the circulation of qi, deodorization, can remove some peculiar smell in powder.
S8, powder are dry: powder be put into drying box and is dried, drying box temperature is maintained at 60-70 degrees Celsius, and
Powder is 10 hours dry in drying box, obtains finished product powder.
S9, powder coating: finished product powder is placed in coating pan again, as the operating of coating pan gradually sets coating powder
Enter in coating pan, powder is coated, reduction powder flavour of a drug distribute lost with part drug effect.At the same time, to coating pan
Middle penetrating bonds liquid, and from hair dryer into coating pan blowing hot-air, the powder in coating operation is dried.
S10, powder pack: the finished product powder after coating is sent into particles packing machine, and powder is quantified loading one by one
Packaging bag in.
Embodiment two:
A kind of condensed pill preparation process, the difference with embodiment one are:
In step s 4, fraction is isolated from the medical fluid of concentration obtains bonding liquid.
In the step s 7, to bonding liquid is sprayed into coating pan, that is, concentrated medicament is sprayed into.
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of condensed pill preparation process, which comprises the steps of:
S1, medicinal material configuration: various medicinal materials weigh by staff and are taken, and separate fried medicine in medicinal material according to quantity from taking
Material and powder medicinal material processed, and fried medicinal material is packed into fried medicine bag；
S2, powder pulverizing medicinal materials processed: crushing powder medicinal material processed, and it is screened obtain thinner medicinal powder, and medicinal powder is divided according to quantity
Mixed powder and spare dry powder out；
S3, medicinal material are fried: fried medicine bag and fried medicinal material being placed in decocting pot, and it is fried to fill the water progress；
S4, medical fluid concentration: after medicinal material is fried, fried medicine bag and fried medicinal material being taken out, to the medical fluid in decocting pot after
It is continuous to be heated, it is concentrated, stops heating decocting pot after the completion of concentration；
S5, it prepares softwood: mixed powder is placed in decocting pot and mixed with the concentrated medicament in decocting pot, and by stirring
It mixes to obtain softwood；
S6, granulation operation: it by softwood item obtained and rubs ball with the hands, powder is made；
S7, whole grain operation: powder being placed in coating pan, and is gradually added spare dry powder in coating pan operational process, and same
When in coating pan spray into bonding liquid；
S8, powder are dry: powder being put into drying box and is dried, finished product powder is obtained.
2. a kind of condensed pill preparation process according to claim 1, which is characterized in that S9, powder coating: again by powder
It is placed in coating pan, processing is coated to powder.
3. a kind of condensed pill preparation process according to claim 2, which is characterized in that before step S1, to prescription into
Row analysis, choosing wherein the more medicinal material of content of starch simply is adjutant；
In step sl, adjutant is individually separated；
In step s 2, adjutant is smashed, obtains coating powder；
In step s 9, as coating powder is gradually placed in coating pan by the operating of coating pan.
4. a kind of condensed pill preparation process according to claim 1, which is characterized in that in step s3, decocting pot is to steam
Vapour double boiler, after liquid boils in decocting pot, then constant temperature cooks 1-2 hours.
5. a kind of condensed pill preparation process according to claim 1, which is characterized in that in step s3, the fried mistake of medicinal material
Cheng Zhong, decocting pot are in closed state.
6. a kind of condensed pill preparation process according to claim 1, which is characterized in that in step s 4, by strainer pair
Medical fluid in fried medicine bag carries out controlling operation, and the medical fluid controlled out is instilled into decocting pot.
7. a kind of condensed pill preparation process according to claim 1, which is characterized in that in step s 6, carried out to powder
The larger powder screened out is back to softwood depending on powder customization size by sieving, mesh density, again pill.
8. a kind of condensed pill preparation process according to claim 1, which is characterized in that in step s 6, by spare dry powder
It is sprinkled upon on the softwood rubbed with the hands in grain operation.
9. a kind of condensed pill preparation process according to claim 1, which is characterized in that in the step s 7, pass through hair dryer
It blows into the coating pan of operation.
10. a kind of condensed pill preparation process according to claim 1, which is characterized in that in step s 8, drying box temperature
It is maintained at 60-70 degrees Celsius, and powder is 10 hours dry in drying box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910617072.3A CN110420194A (en) | 2019-07-09 | 2019-07-09 | A kind of condensed pill preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910617072.3A CN110420194A (en) | 2019-07-09 | 2019-07-09 | A kind of condensed pill preparation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110420194A true CN110420194A (en) | 2019-11-08 |
Family
ID=68410410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910617072.3A Pending CN110420194A (en) | 2019-07-09 | 2019-07-09 | A kind of condensed pill preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110420194A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB523594A (en) * | 1938-05-02 | 1940-07-18 | Israel Lipowski | A process for producing carriers for medicinal substances |
| CN1943737A (en) * | 2005-10-08 | 2007-04-11 | 刘国飞 | A Chinese traditional medicinal composition used for treatment of nephritis and its preparation method |
| CN102309412A (en) * | 2011-10-19 | 2012-01-11 | 祖畅 | Low-temperature-boiling decocting (extracting) machine |
| CN103083546A (en) * | 2013-02-23 | 2013-05-08 | 盛翔 | Method for processing condensed pill for regaining sight |
| CN104224726A (en) * | 2013-06-17 | 2014-12-24 | 天士力制药集团股份有限公司 | Preparation method of traditional Chinese medicine pellet |
| CN104383713A (en) * | 2014-09-23 | 2015-03-04 | 泰山医学院 | Extraction method for medical tea active components |
| CN105943390A (en) * | 2016-05-03 | 2016-09-21 | 上海和黄药业有限公司 | Method for improving mechanical pelleting yield and applications of method |
| CN109718353A (en) * | 2019-03-15 | 2019-05-07 | 吴佳玲 | The traditional Chinese medicine pill and preparation method thereof for treating constipation |
-
2019
- 2019-07-09 CN CN201910617072.3A patent/CN110420194A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB523594A (en) * | 1938-05-02 | 1940-07-18 | Israel Lipowski | A process for producing carriers for medicinal substances |
| CN1943737A (en) * | 2005-10-08 | 2007-04-11 | 刘国飞 | A Chinese traditional medicinal composition used for treatment of nephritis and its preparation method |
| CN102309412A (en) * | 2011-10-19 | 2012-01-11 | 祖畅 | Low-temperature-boiling decocting (extracting) machine |
| CN103083546A (en) * | 2013-02-23 | 2013-05-08 | 盛翔 | Method for processing condensed pill for regaining sight |
| CN103083546B (en) * | 2013-02-23 | 2014-04-30 | 盛翔 | Method for processing condensed pill for regaining sight |
| CN104224726A (en) * | 2013-06-17 | 2014-12-24 | 天士力制药集团股份有限公司 | Preparation method of traditional Chinese medicine pellet |
| CN104383713A (en) * | 2014-09-23 | 2015-03-04 | 泰山医学院 | Extraction method for medical tea active components |
| CN105943390A (en) * | 2016-05-03 | 2016-09-21 | 上海和黄药业有限公司 | Method for improving mechanical pelleting yield and applications of method |
| CN109718353A (en) * | 2019-03-15 | 2019-05-07 | 吴佳玲 | The traditional Chinese medicine pill and preparation method thereof for treating constipation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108926028A (en) | Heat the preparation method and its sucked material of cigarette sucked material of not burning | |
| NO146660B (en) | PROCEDURE FOR MANUFACTURING THE SOFT DINATE CHROMOGLYCLE PELLET | |
| CN102423049B (en) | Instant fern powder and production method thereof | |
| CN107115309A (en) | A kind of Chinese medicine water pill preparation method | |
| JP2021031488A (en) | Pellet formulation containing single or complex herbal extract at high concentration and manufacturing method therefor | |
| CN110420194A (en) | A kind of condensed pill preparation process | |
| CN109874904A (en) | A kind of blueberry pomace pressed candy and preparation method thereof | |
| CN108244511B (en) | Preparation method of rubber beads | |
| CN1330318C (en) | Preparation of pills by pressing process | |
| CN112515100A (en) | Instant cereal dry fruit meal replacement porridge (powder) and preparation method thereof | |
| CN110051818A (en) | A kind of preparation method of the direct oral traditional Chinese medicine medicine materical crude slice of nourishing the stomach reducing internal heat | |
| CN107468655B (en) | Lentinan particles and preparation method thereof | |
| CN101708173B (en) | Soft capsule and application thereof | |
| CN105664790B (en) | A kind of tea polyphenols fluidized bed granulation method | |
| CN103520225B (en) | A kind of Folium Ginkgo capsule and preparation method thereof | |
| CN108185415A (en) | A kind of preparation method of the glue bead containing volatile materials | |
| CN106727809B (en) | A kind of preparation method of ginseng ultra micro pure powder tablet | |
| CN110075080A (en) | A kind of 3D printing rapidly dissolving tablet of Chinese medical extract and preparation method thereof | |
| CN101439107B (en) | Chinese medicine granule containing haw thorn extract and preparation method thereof | |
| CN106924192A (en) | A kind of Chinese herbal granules and preparation method thereof | |
| CN100441112C (en) | Method for preparing health food for alleviating physical strength fatigue | |
| CN104997869B (en) | The preparation method of Lear dormancy piece | |
| CN109303880A (en) | Smilax china L coated pellet and its preparation process | |
| CN100540032C (en) | A kind of preparation method for the treatment of the pharmaceutical preparation of cough | |
| CN100548330C (en) | A kind of preparation method for the treatment of the pharmaceutical preparation of intestinal tract disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191108 |
|
| RJ01 | Rejection of invention patent application after publication |