CN110396133B - 一种以白介素12为活性成分的融合蛋白型药物前体 - Google Patents

一种以白介素12为活性成分的融合蛋白型药物前体 Download PDF

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CN110396133B
CN110396133B CN201810376920.1A CN201810376920A CN110396133B CN 110396133 B CN110396133 B CN 110396133B CN 201810376920 A CN201810376920 A CN 201810376920A CN 110396133 B CN110396133 B CN 110396133B
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CN110396133A (zh
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傅阳心
彭华
薛娣媛
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Shanghai Kangkang Biotechnology Co.,Ltd.
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Immune Targeting Inc
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Priority to CN201810376920.1A priority Critical patent/CN110396133B/zh
Application filed by Immune Targeting Inc filed Critical Immune Targeting Inc
Priority to BR112020021791-3A priority patent/BR112020021791A2/pt
Priority to CA3097995A priority patent/CA3097995A1/en
Priority to EA202092459A priority patent/EA202092459A1/ru
Priority to CN201980042842.4A priority patent/CN112638938A/zh
Priority to EP19792585.2A priority patent/EP3810639A4/en
Priority to KR1020207033158A priority patent/KR20210024446A/ko
Priority to US17/049,021 priority patent/US12473337B2/en
Priority to PCT/US2019/028933 priority patent/WO2019209965A2/en
Priority to AU2019261411A priority patent/AU2019261411B2/en
Priority to JP2020559408A priority patent/JP2021521822A/ja
Publication of CN110396133A publication Critical patent/CN110396133A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN201810376920.1A 2018-04-25 2018-04-25 一种以白介素12为活性成分的融合蛋白型药物前体 Active CN110396133B (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN201810376920.1A CN110396133B (zh) 2018-04-25 2018-04-25 一种以白介素12为活性成分的融合蛋白型药物前体
PCT/US2019/028933 WO2019209965A2 (en) 2018-04-25 2019-04-24 Interleukin 12 fusion proteins, and compositions and therapeutic methods thereof
EA202092459A EA202092459A1 (ru) 2018-04-25 2019-04-24 Гибридные белки интерлейкина 12, композиции и способы терапевтического применения, которые их включают
CN201980042842.4A CN112638938A (zh) 2018-04-25 2019-04-24 白介素12融合蛋白及其组合物和治疗方法
EP19792585.2A EP3810639A4 (en) 2019-04-24 Interleukin 12 fusion proteins, and compositions and therapeutic methods thereof
KR1020207033158A KR20210024446A (ko) 2018-04-25 2019-04-24 인터루킨 12 융합 단백질 및 이의 조성물 및 치료 방법
BR112020021791-3A BR112020021791A2 (pt) 2018-04-25 2019-04-24 proteínas de fusão de interleucina 12 e composições e métodos terapêuticos das mesmas
CA3097995A CA3097995A1 (en) 2018-04-25 2019-04-24 Interleukin 12 fusion proteins, and compositions and therapeutic methods thereof
AU2019261411A AU2019261411B2 (en) 2018-04-25 2019-04-24 Interleukin 12 fusion proteins, and compositions and therapeutic methods thereof
JP2020559408A JP2021521822A (ja) 2018-04-25 2019-04-24 インターロイキン１２融合タンパク質および組成物、ならびにその治療方法
US17/049,021 US12473337B2 (en) 2018-04-25 2019-04-24 Homodimeric or heterodimeric interleukin 12 fusion proteins, and compositions and therapeutic methods thereof
JP2024197045A JP2025032113A (ja) 2018-04-25 2024-11-11 インターロイキン１２融合タンパク質および組成物、ならびにその治療方法

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CN201810376920.1A CN110396133B (zh) 2018-04-25 2018-04-25 一种以白介素12为活性成分的融合蛋白型药物前体

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CN110396133A CN110396133A (zh) 2019-11-01
CN110396133B true CN110396133B (zh) 2021-07-23

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CN201810376920.1A Active CN110396133B (zh) 2018-04-25 2018-04-25 一种以白介素12为活性成分的融合蛋白型药物前体
CN201980042842.4A Pending CN112638938A (zh) 2018-04-25 2019-04-24 白介素12融合蛋白及其组合物和治疗方法

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US (1) US12473337B2 (enExample)
JP (2) JP2021521822A (enExample)
KR (1) KR20210024446A (enExample)
CN (2) CN110396133B (enExample)
AU (1) AU2019261411B2 (enExample)
BR (1) BR112020021791A2 (enExample)
CA (1) CA3097995A1 (enExample)
EA (1) EA202092459A1 (enExample)
WO (1) WO2019209965A2 (enExample)

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CN111094330A (zh) 2017-07-03 2020-05-01 转矩医疗股份有限公司 编码免疫刺激融合分子的多核苷酸及其用途
CN112534052B (zh) 2018-07-25 2024-09-20 奥美药业有限公司 全新il-21前药及使用方法
CN121971599A (zh) 2019-02-25 2026-05-05 芝加哥大学 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物
WO2020252264A1 (en) 2019-06-12 2020-12-17 AskGene Pharma, Inc. Novel il-15 prodrugs and methods of use thereof
JP7682150B2 (ja) * 2019-07-25 2025-05-23 ザ・ユニバーシティ・オブ・シカゴ プロテアーゼ活性化治療剤を含む組成物および方法
JP7767290B2 (ja) 2020-01-11 2025-11-11 アスクジーン・ファーマ・インコーポレイテッド 新規なマスクされたサイトカインおよびその使用方法
CN115734806A (zh) * 2020-04-01 2023-03-03 西里欧发展公司 掩蔽的il-12细胞因子和其切割产物
JP2023553323A (ja) * 2020-11-25 2023-12-21 エクシリオ デベロップメント， インコーポレイテッド 腫瘍特異的に切断可能なリンカー
CN116601175A (zh) * 2020-12-18 2023-08-15 豪夫迈·罗氏有限公司 用于靶向疗法的前体蛋白和试剂盒
EP4314073A4 (en) * 2021-03-24 2025-02-19 Alkermes, Inc. Upar antibodies and fusion proteins with the same
JP2024516610A (ja) * 2021-04-21 2024-04-16 キュー バイオファーマ， インコーポレイテッド Ｍｈｃクラスｉｉ ｔ細胞調節ポリペプチド及びその使用方法
CA3226924A1 (en) 2021-07-19 2023-01-26 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
EP4419545A4 (en) 2021-10-20 2025-10-22 Synthekine Inc HETERODIMERIC FC CYTOKINES AND THEIR USES
IL322055A (en) * 2023-01-13 2025-09-01 Regeneron Pharma IL12 receptor agonists and methods of using them
AU2024251934A1 (en) 2023-04-12 2025-10-30 Shanghai Kangabio Co., Limited Multifunctional molecules comprising masked interleukin 12 and methods of use
TW202523680A (zh) * 2023-12-07 2025-06-16 大陸商上海藥明生物技術有限公司 針對ｉｌ－１２受體的異二聚體蛋白
WO2025256578A1 (zh) * 2024-06-12 2025-12-18 龙启生物制药(杭州)有限公司 Treg细胞靶向IL12融合蛋白及其制备、治疗方法
WO2026020161A1 (en) * 2024-07-19 2026-01-22 Cytomx Therapeutics, Inc. Activatable il-12 constructs and related compositions and methods

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CN105218682A (zh) * 2015-10-26 2016-01-06 深圳精准医疗科技有限公司 经il-12/cd62l融合蛋白改造的肿瘤治疗剂及其制法和用途
CN105543279A (zh) * 2014-10-30 2016-05-04 常州卡斯比生物科技有限公司 一种防治辐射线损伤、肿瘤治疗的IL-12/Fc融合蛋白的制备方法及其药剂
WO2018030806A1 (ko) * 2016-08-10 2018-02-15 아주대학교산학협력단 항체 중쇄불변부위 이종이중체에 융합된 사이토카인 및 이를 포함하는 약제학적 조성물

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EP1418184A1 (en) * 2002-11-08 2004-05-12 Cell Center Cologne GmbH Recombinant fusion protein consisting of the p40 and p35 subunits of IL-12 and a ScFv and use thereof
CN105543279A (zh) * 2014-10-30 2016-05-04 常州卡斯比生物科技有限公司 一种防治辐射线损伤、肿瘤治疗的IL-12/Fc融合蛋白的制备方法及其药剂
CN105218682A (zh) * 2015-10-26 2016-01-06 深圳精准医疗科技有限公司 经il-12/cd62l融合蛋白改造的肿瘤治疗剂及其制法和用途
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BR112020021791A2 (pt) 2021-02-23
WO2019209965A3 (en) 2019-12-05
AU2019261411A1 (en) 2020-11-26
JP2025032113A (ja) 2025-03-11
US20220162280A1 (en) 2022-05-26
WO2019209965A2 (en) 2019-10-31
CA3097995A1 (en) 2019-10-31
KR20210024446A (ko) 2021-03-05
JP2021521822A (ja) 2021-08-30
EA202092459A1 (ru) 2021-06-15
US12473337B2 (en) 2025-11-18
CN110396133A (zh) 2019-11-01
CN112638938A (zh) 2021-04-09
AU2019261411B2 (en) 2024-11-14
EP3810639A2 (en) 2021-04-28

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