CN110381975A - 一种硼替佐米药物组合物及其应用 - Google Patents

一种硼替佐米药物组合物及其应用 Download PDF

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Publication number
CN110381975A
CN110381975A CN201780075214.7A CN201780075214A CN110381975A CN 110381975 A CN110381975 A CN 110381975A CN 201780075214 A CN201780075214 A CN 201780075214A CN 110381975 A CN110381975 A CN 110381975A
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parts
bortezomib
acid
release
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甘勇
朱全垒
朱春柳
季亮
金宇良
郭仕艳
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Ningbo Ningrong Biopharma Co ltd
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Ningbo Ningrong Biopharma Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

一种硼替佐米药物组合物及其应用，该组合物包含0.1‑200重量份的硼替佐米、0.1‑500重量份的释放速率调节用辅料，0‑1000重量份的小分子调节剂，和0‑2000重量份的药用可注射溶剂。硼替佐米药物组合物在制备用于治疗难治/复发多发性骨髓瘤的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201780075214.7A 2016-12-16 2017-12-15 一种硼替佐米药物组合物及其应用 Pending CN110381975A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016111686998 2016-12-16
CN201611168699.8A CN108201622A (zh) 2016-12-16 2016-12-16 一种硼替佐米药物组合物及其应用
PCT/CN2017/116587 WO2018108164A1 (zh) 2016-12-16 2017-12-15 一种硼替佐米药物组合物及其应用

Publications (1)

Publication Number Publication Date
CN110381975A true CN110381975A (zh) 2019-10-25

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CN201611168699.8A Pending CN108201622A (zh) 2016-12-16 2016-12-16 一种硼替佐米药物组合物及其应用
CN201780075214.7A Pending CN110381975A (zh) 2016-12-16 2017-12-15 一种硼替佐米药物组合物及其应用

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CN (2) CN108201622A (zh)
WO (1) WO2018108164A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024067840A1 (zh) * 2022-09-30 2024-04-04 上海济煜医药科技有限公司 一种脂质体及其制备方法和应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108201622A (zh) * 2016-12-16 2018-06-26 宁波宁融生物医药有限公司 一种硼替佐米药物组合物及其应用
CN109045272A (zh) * 2018-08-01 2018-12-21 厦门市壳聚糖生物科技有限公司 一种硼替佐米磷脂复合物及其制备方法与应用
CN110063932A (zh) * 2019-04-12 2019-07-30 浙江大学 一种多肽蛋白类药物的缓释组合物制剂及其制备方法
CN115990134B (zh) * 2022-11-08 2024-05-10 四川大学华西医院 一种可注射水凝胶/纳米凝胶载药缓释体系及其制备方法和用途

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Publication number Priority date Publication date Assignee Title
CN101204365A (zh) * 2007-11-29 2008-06-25 济南帅华医药科技有限公司 一种治疗实体肿瘤的植入剂
US20110178470A1 (en) * 2008-10-01 2011-07-21 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions comprising boronic acid compounds
CN104548116A (zh) * 2013-10-11 2015-04-29 程树海 一种稳定的蛋白质载药微粒系统制备方法
CN105496960A (zh) * 2015-12-19 2016-04-20 江苏亚邦强生药业有限公司 一种硼替佐米注射剂及其制备方法
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CN101336926A (zh) * 2008-07-28 2009-01-07 济南基福医药科技有限公司 同载硼替佐米和烷化剂的抗癌组合物

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US20110178470A1 (en) * 2008-10-01 2011-07-21 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions comprising boronic acid compounds
CN104548116A (zh) * 2013-10-11 2015-04-29 程树海 一种稳定的蛋白质载药微粒系统制备方法
CN105496960A (zh) * 2015-12-19 2016-04-20 江苏亚邦强生药业有限公司 一种硼替佐米注射剂及其制备方法
CN108201622A (zh) * 2016-12-16 2018-06-26 宁波宁融生物医药有限公司 一种硼替佐米药物组合物及其应用

Non-Patent Citations (2)

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AMIN GHAVAMINEJAD等: "pH/NIR Light-Controlled Multidrug Release via a Mussel-Inspired Nanocomposite Hydrogel for Chemo-Photothermal Cancer Therapy", 《SCIENTIFIC REPORTS》 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024067840A1 (zh) * 2022-09-30 2024-04-04 上海济煜医药科技有限公司 一种脂质体及其制备方法和应用

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WO2018108164A1 (zh) 2018-06-21
CN108201622A (zh) 2018-06-26

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Application publication date: 20191025