CN110381942B - 包含珀奈莫德的药物组合 - Google Patents

包含珀奈莫德的药物组合 Download PDF

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Publication number
CN110381942B
CN110381942B CN201880017102.0A CN201880017102A CN110381942B CN 110381942 B CN110381942 B CN 110381942B CN 201880017102 A CN201880017102 A CN 201880017102A CN 110381942 B CN110381942 B CN 110381942B
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China
Prior art keywords
active ingredient
pharmaceutical composition
teriflunomide
treatment
leflunomide
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CN201880017102.0A
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Chinese (zh)
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CN110381942A (zh
Inventor
马丁尼·克劳泽
蕾蒂西娅·普佐
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Zhuvies Pharmaceutical Laboratory Co Ltd
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Actelion Pharmaceuticals Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
CN201880017102.0A 2017-03-14 2018-03-13 包含珀奈莫德的药物组合 Active CN110381942B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2017055994 2017-03-14
EPPCT/EP2017/055994 2017-03-14
PCT/EP2018/056185 WO2018167030A1 (en) 2017-03-14 2018-03-13 Pharmaceutical combination comprising ponesimod

Publications (2)

Publication Number Publication Date
CN110381942A CN110381942A (zh) 2019-10-25
CN110381942B true CN110381942B (zh) 2022-12-27

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CN201880017102.0A Active CN110381942B (zh) 2017-03-14 2018-03-13 包含珀奈莫德的药物组合

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US (2) US11723896B2 (enExample)
EP (1) EP3595657A1 (enExample)
JP (3) JP7281406B2 (enExample)
KR (1) KR102574562B1 (enExample)
CN (1) CN110381942B (enExample)
AU (2) AU2018233109B2 (enExample)
BR (1) BR112019018894A2 (enExample)
CA (1) CA3056301C (enExample)
CL (1) CL2019002525A1 (enExample)
CO (1) CO2019008510A2 (enExample)
CR (1) CR20190464A (enExample)
DO (1) DOP2019000257A (enExample)
EA (1) EA201992117A1 (enExample)
EC (1) ECSP19073317A (enExample)
IL (1) IL269239B2 (enExample)
JO (1) JOP20190207A1 (enExample)
MA (1) MA49822A (enExample)
MX (1) MX390941B (enExample)
NI (1) NI201900092A (enExample)
PE (1) PE20191489A1 (enExample)
PH (1) PH12019502110A1 (enExample)
SG (1) SG11201907308UA (enExample)
UA (1) UA125756C2 (enExample)
WO (1) WO2018167030A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof

Citations (2)

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CN104684553A (zh) * 2012-08-03 2015-06-03 前进制药公司 治疗多发性硬化症的组合疗法
WO2016091996A1 (en) * 2014-12-11 2016-06-16 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist

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ES448386A1 (es) 1975-06-05 1978-04-16 Hoechst Ag Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
US5268382A (en) 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
DE60110043T2 (de) * 2000-02-15 2006-03-02 Teva Pharmaceutical Industries Ltd. Methode zur synthetisierung von leflunomid
GB0123571D0 (en) * 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
SI1381356T1 (sl) * 2001-04-05 2008-12-31 Aventis Pharma Inc Uporaba (Z)-2-ciano-3-hidroksi-but-2-enojska kislina-(4'-trifluorometilfenil)-amida za zdravljenje multiple skleroze
US6894184B2 (en) 2003-03-18 2005-05-17 Aventis Pharma Deutschland Gmbh Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides
CA2545582C (en) 2003-11-21 2013-04-16 Actelion Pharmaceuticals Ltd 5-(benz-(z)-ylidene)-thiazolidin-4-one derivatives as immunosuppressant agents
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
MX2007004265A (es) 2004-10-19 2008-03-04 Aventis Pharma Inc Uso de (4'trifluorometilfenil) -amida del acido (z) - 2 - ciano - 3 - hidroxi-but - 2- enoico para tratar la enfermedad inflamatoria del intestino.
DE102006017896A1 (de) 2006-04-13 2007-10-25 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Leflunomid enthaltende pharmazeutische Zusammensetzungen
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CN101541772B (zh) 2006-11-23 2013-04-17 埃科特莱茵药品有限公司 一种制备2-亚氨基-四氢噻唑-4-酮衍生物的新方法
PT2278960T (pt) 2008-03-17 2017-03-09 Actelion Pharmaceuticals Ltd Regime de dosagem para um agonista seletivo do recetor s1p1
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
UA107582C2 (uk) 2009-09-18 2015-01-26 Таблетований препарат (4'-трифторметилфеніл)аміду (z)-2-ціано-гідроксибут-2-еноєвої кислоти з поліпшеною стійкістю
WO2012015758A2 (en) 2010-07-30 2012-02-02 Saint Louis University Methods of treating pain
AR082436A1 (es) 2010-08-02 2012-12-05 Sanofi Aventis Us Llc Uso de teriflunomida para tratar la esclerosis multiple
RS60408B1 (sr) 2012-08-17 2020-07-31 Actelion Pharmaceuticals Ltd Postupak za pripremanje (2z,5z)-5-(3-hloro-4-((r)-2,3-dihidroksipropoksi)benziliden)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona i međujedinjenja upotrebljena u pomenutom postupku
WO2016079687A1 (en) 2014-11-18 2016-05-26 Lupin Limited Oral pharmaceutical composition of teriflunomide
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
CN107920991A (zh) 2015-06-18 2018-04-17 马丁尼斯生物制药纳米技术公司 治疗炎性疾病或病状的组合物和方法
JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود

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CN104684553A (zh) * 2012-08-03 2015-06-03 前进制药公司 治疗多发性硬化症的组合疗法
WO2016091996A1 (en) * 2014-12-11 2016-06-16 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist

Also Published As

Publication number Publication date
CR20190464A (es) 2019-11-26
PE20191489A1 (es) 2019-10-21
CN110381942A (zh) 2019-10-25
AU2023274118B2 (en) 2024-12-12
MX2019010874A (es) 2019-12-11
NI201900092A (es) 2020-03-11
JP2020510045A (ja) 2020-04-02
CA3056301A1 (en) 2018-09-20
KR102574562B1 (ko) 2023-09-04
AU2018233109A1 (en) 2019-08-22
JP2024096962A (ja) 2024-07-17
IL269239B2 (en) 2023-07-01
MA49822A (fr) 2020-06-17
AU2023274118A1 (en) 2023-12-21
CA3056301C (en) 2024-10-01
US11723896B2 (en) 2023-08-15
ECSP19073317A (es) 2019-11-30
IL269239A (en) 2019-11-28
JOP20190207A1 (ar) 2019-09-10
US20200069655A1 (en) 2020-03-05
EA201992117A1 (ru) 2020-02-17
AU2018233109B2 (en) 2023-09-28
JP7281406B2 (ja) 2023-05-25
SG11201907308UA (en) 2019-09-27
BR112019018894A2 (pt) 2020-04-14
JP2023030091A (ja) 2023-03-07
IL269239B1 (en) 2023-03-01
MX390941B (es) 2025-03-21
PH12019502110A1 (en) 2020-03-16
EP3595657A1 (en) 2020-01-22
CO2019008510A2 (es) 2019-10-21
KR20190122716A (ko) 2019-10-30
UA125756C2 (uk) 2022-06-01
DOP2019000257A (es) 2020-09-15
WO2018167030A1 (en) 2018-09-20
CL2019002525A1 (es) 2020-02-07
US20240139161A1 (en) 2024-05-02

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Effective date of registration: 20250924

Address after: Villeurbanne, France

Patentee after: Zhuvies Pharmaceutical Laboratory Co., Ltd.

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Address before: Swiss A Skei Weil

Patentee before: ACTELION PHARMACEUTICALS Ltd.

Country or region before: Switzerland