CN110376393B

CN110376393B - Reaction disc with solid direct-heating structure and full-automatic biochemical analyzer thereof

Info

Publication number: CN110376393B
Application number: CN201910774506.0A
Authority: CN
Inventors: 郭成哲; 吴海波; 王丹民
Original assignee: Neusoft Weiteman Biotechnology Shenyang Co ltd
Current assignee: Neusoft Weiteman Biotechnology Shenyang Co ltd
Priority date: 2019-08-21
Filing date: 2019-08-21
Publication date: 2023-05-30
Anticipated expiration: 2039-08-21
Also published as: CN110376393A

Abstract

The application discloses a reaction plate with a solid direct-heating structure and a full-automatic biochemical analyzer thereof. The reaction disk includes a disk body and a shutter. The tray body is hollow cylindric, and the surface of tray body evenly is provided with the slot tooth, every the extending direction of slot tooth is parallel with the axial of tray body, and adjacent slot tooth forms the opening. The shielding piece is connected with the groove teeth and shields the opening to form a plurality of cuvette notches with the groove teeth. Because the surface of the disk body is provided with a plurality of adjacent groove teeth, the adjacent groove teeth form openings, and the shielding piece shields the openings to form a plurality of cuvette notches, the processing difficulty of the cuvette notches is low, the cost is low and the structure is simple.

Description

Reaction disc with solid direct-heating structure and full-automatic biochemical analyzer thereof

Technical Field

The application relates to a full-automatic biochemical analyzer, in particular to a reaction disc with a solid direct-heating structure and the full-automatic biochemical analyzer thereof.

Background

At present, the constant temperature incubation mode adopted by the full-automatic biochemical analyzer mainly comprises three modes of air bath, water bath/constant temperature liquid bath and solid direct heating (solid direct contact constant temperature). The constant temperature mode of the air bath has the advantages of simple structure and low cost, and has the defects of slower heating of the system, environmental influence on the temperature and instability. The constant temperature mode of the water bath/constant temperature liquid bath has the advantages of uniform and stable temperature, higher manufacturing cost, longer startup preheating time, influence on light path photometry due to water quality change (such as microorganism and mineral precipitation) and great maintenance work. The constant temperature mode of solid direct heating has the advantages that the reaction liquid in the reaction cup is heated quickly, and is uniform and stable.

The existing reaction plate with a solid direct heating structure generally has the following two modes. The first is that the notch of the cuvette consists of two half-grooves. The reaction disk generally comprises a chassis, a main disk, a reaction cup clamping device and the like, wherein the main disk and the reaction cup clamping device are connected to the chassis, half grooves for placing reaction cups are respectively processed on the main disk and the reaction cup clamping device, rectangular grooves for placing the reaction cups are formed after the main disk and the reaction cup clamping device are arranged on the chassis, and the reaction cups are directly clamped by the clamping device after being placed in the grooves. The second is finish machining treatment after the notch of the cuvette is integrally formed.

The existing reaction plate with the solid direct-heating structure has the following advantages and disadvantages:

1. the notch of the cuvette is in an integrated post-finish machining treatment mode, so that the processing difficulty is high and the cost is high;

2. the notch of the cuvette consists of two half grooves, and has a complex structure and high cost;

3. only the bottom is provided with a heating body, and the heating is uneven.

Disclosure of Invention

To overcome some or all of the problems in the related art, embodiments of the present application provide a reaction tray of a solid direct thermal structure. The reaction disk includes a disk body and a shutter. The tray body is hollow cylindric, and the surface of tray body evenly is provided with the slot tooth, every the extending direction of slot tooth is parallel with the axial of tray body, and adjacent slot tooth forms the opening. The shielding piece is connected with the groove teeth and shields the opening to form a plurality of cuvette notches with the groove teeth.

Optionally, the shield comprises a retainer and a bottom ring, the bottom ring comprising a bottom wall, an outer wall and an inner wall, the outer wall, the inner wall and the bottom wall enclosing a slot. The retainer is hollow cylindrical. The top surface of each groove tooth is flush with the top surface of the tray body, and the height value of each groove tooth is larger than that of the tray body so that each groove tooth is provided with an insertion part. The shielding piece is connected with the groove teeth, shields the opening and is connected with the groove teeth to form a plurality of cuvette notches, and the shielding piece comprises: the insertion part is inserted into the slot, the bottom surface of the retainer is contacted with the outer wall, and the bottom surface of the tray body is contacted with the inner wall.

Optionally, a plurality of first light holes have been seted up to the outer wall, a plurality of second light holes have been seted up to the inner wall, each cuvette notch intercommunication is one first light hole and one the second light hole is located same light path.

Optionally, the shielding piece comprises a retainer and a bottom wall, and the retainer is hollow cylindrical; the bottom wall is in a circular ring shape. The top surface of each groove tooth is flush with the top surface of the tray body, and the height value of each groove tooth is equal to the height value of the tray body. The shielding piece is connected with the groove teeth, shields the opening and is connected with the groove teeth to form a plurality of cuvette notches, and the shielding piece comprises: the guard ring is connected with the side face of each groove tooth, and the bottom wall is connected with the bottom face of the groove tooth, the bottom face of the tray body and the bottom face of the guard ring.

Optionally, a plurality of first light holes have been seted up to the lower part of retainer, a plurality of second light holes have been seted up to the lower part of disk body, each cuvette notch intercommunication is one first light hole and one the second light hole is located same light path.

Optionally, the retainer and the bottom wall are integrally constructed.

Optionally, the guard ring is formed by connecting a plurality of sections of guard plates end to end.

Optionally, the inner surface of the tray body is provided with a side heating body mounting groove, and the side heating body mounting groove winds around the inner surface of the tray body for a circle.

Optionally, the shielding piece is provided with a bottom wall, the bottom wall is circular, the outer surface of the bottom wall is provided with a bottom heating body mounting groove, and the bottom heating body mounting groove surrounds the bottom wall for a circle.

Optionally, the top surface of the tray body is provided with a fence, the fence winds the tray body for a circle, and the diameter of the fence is smaller than the diameter of the tray body and forms a step with the tray body.

Optionally, the reaction disc includes a support plate, the support plate extends along the radial direction of the disc body and is connected to the enclosure, and temperature sensor wiring grooves are uniformly distributed on the upper surface of the support plate. The outside surface of enclosure is formed with the temperature sensor mounting hole that extends to the step is inside, and every temperature sensor mounting hole and a temperature sensor wiring groove intercommunication constitutes the passageway that the cross-section was L shape.

Optionally, in the temperature sensor wiring groove, a calibration temperature sensor wiring groove is disposed between adjacent temperature sensor wiring grooves, a calibration temperature sensor mounting hole is disposed between adjacent temperature sensor mounting holes, and the calibration temperature sensor mounting hole and the calibration temperature sensor wiring groove are communicated to form a channel with an L-shaped section.

Optionally, the reaction plate includes a support plate extending in a radial direction of the plate body and connected to the enclosure wall, and an upper surface of the support plate is provided with an overheat protection sensor mounting groove.

In another aspect, the present application provides a fully automated biochemical analyzer. The analyzer comprises a reaction disk of any one of the aforementioned solid direct thermal structures.

The technical scheme provided by the embodiment of the application can comprise the following beneficial effects:

1. because the surface of the disk body is provided with a plurality of adjacent groove teeth, the adjacent groove teeth form openings, and the shielding piece shields the openings and forms a plurality of cuvette notches with the groove teeth, the processing difficulty of the cuvette notches is low, the cost is low and the structure is simple.

2. As the step is formed between the tray body and the enclosing wall, a cuvette releasing area or a cuvette clamping area can be formed through the step, so that the cuvette is fixed and the fixing mode is flexible.

3. The side heating body mounting groove is formed in the inner surface of the tray body, and the bottom heating body mounting groove is formed in the bottom wall of the shielding piece, so that the side heating body and the bottom heating body are heated uniformly.

4. Because the bottom ring includes diapire, outer wall and inner wall, and diapire, outer wall and inner wall enclose into the fluting, this kind of structural design can be with the reaction cup package, ensures constant temperature effect.

5. Because evenly distributed has temperature sensor wiring groove and is provided with temperature sensor mounting hole at the surface of enclosure in the backup pad, like this, can in time learn the temperature, especially, be provided with under the circumstances that calibration temperature sensor wiring groove and calibration temperature sensor mounting hole, evenly distributed adds the detection precision that the calibration mode can guarantee the sensor and survey.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the application and together with the description, serve to explain the principles of the application.

FIG. 1 is a cross-sectional view of a reaction tray of a solid direct thermal structure according to one embodiment of the present application;

FIG. 2 is an enlarged partial view of portion A of FIG. 1;

FIG. 3 is a schematic structural view of a reaction plate body assembled by a plate body, a retainer ring, a bottom ring, a rotating plate and a heat insulating plate of a solid direct heating structure according to one embodiment of the present application;

FIG. 4 is a schematic view of the structure of the tray body of the reaction tray shown in FIG. 1;

FIG. 5 is a cross-sectional view taken along line B-B of FIG. 4;

FIG. 6 is an enlarged partial view of portion C of FIG. 5;

FIG. 7 is a schematic view of the bottom ring of the reaction disk of FIG. 1;

FIG. 8 is a cross-sectional view taken along line D-D of FIG. 7;

fig. 9 is a schematic view of another structure of the tray.

Detailed Description

Reference will now be made in detail to exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, the same numbers in different drawings refer to the same or similar elements, unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. Rather, they are merely examples of apparatus and methods consistent with some aspects of the present application as detailed in the accompanying claims.

The terminology used in the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the present application. As used in this application and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

It should be understood that the terms "first," "second," and the like, as used in the specification and the claims herein, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. Likewise, the terms "a" or "an" and the like do not denote a limitation of quantity, but rather denote the presence of at least one; "plurality" means two and more than two. Unless otherwise indicated, the terms "front," "rear," "lower," and/or "upper" and the like are merely for convenience of description and are not limited to one location or one spatial orientation. The word "comprising" or "comprises", and the like, means that elements or items appearing before "comprising" or "comprising" are encompassed by the element or item recited after "comprising" or "comprising" and equivalents thereof, and that other elements or items are not excluded.

Exemplary embodiments of the present application will be described in detail below with reference to the accompanying drawings. The following embodiments and features of the embodiments may be complemented or combined with each other without conflict.

Referring to fig. 1 to 8, and particularly fig. 4 to 6, a reaction disk of the present embodiment includes a disk body 1 and a shutter. The tray body 1 has a hollow cylindrical shape. The tray 1 has an outer surface 111, an inner surface 112, a top surface 113 and a bottom surface 114. The outer surface 111 of the tray body 1 is uniformly provided with the groove teeth 12. The top surface 121 of each of the groove teeth 12 is flush with the top surface 113 of the disk body 1 in a direction parallel to the axial direction of the disk body 1 and the height value of each of the groove teeth 12 is larger than the height value of the disk body 1 so that each of the groove teeth 12 has an insertion portion 122. Openings 13 are formed between adjacent ones of the teeth 12. The shutter is connected to the slit 12, and the shutter closes the opening 13 to form a plurality of cuvette notches 123 with the slit 12. In this embodiment, the shield comprises a retainer 2 and a bottom ring 3. The construction of the tray 1 and the shutter is described in more detail below.

With continued reference to fig. 6, and in combination with fig. 1, 2 and 5, the inner surface 112 of the tray 1 is provided with a side heating body mounting groove 14, and the mounting groove 14 is used for mounting a heating body. The side heating body mounting groove 14 is located around the inner surface of the tray body 1 between the top surface 113 and the bottom surface 114 of the tray body 1.

Referring to fig. 4 to 6, the top surface 113 of the tray 1 is provided with a wall 15. The perimeter wall 15 surrounds the tray 1 for one week. The diameter of the enclosing wall 15 is smaller than the diameter of the tray 1 and forms a step 16 with the tray 1, and the step 16 comprises a top surface 113 because the top surfaces 121 of the groove teeth 12 are flush with the top surface 113 of the tray 1. The step 16 and the outer surface of the wall 15 define a cuvette holder release zone for holding the cuvette when the cuvette is held by the cuvette holder 9 (see fig. 1 and 2). When the cuvette is fixed by the clamping rubber, a rubber band for clamping the cuvette can be placed between the outer surface of the step 16 and the enclosing wall 15 and the cuvette for fixing the cuvette.

Referring to fig. 3 in combination with fig. 4 and 5, the reaction plate includes a support plate 17, and the support plate 17 extends in the radial direction of the plate body 1 and is connected to the enclosing wall 15. The supporting plate 17 is substantially circular, and a rotating disk 4 is disposed at the center of the circle. A heat insulating plate 5 is arranged between the rotating disc 4 and the supporting plate 17. The tray body 1, the guard ring 2, the bottom ring 3, the rotating tray 4 and the nonmetal heat insulation plate 5 are assembled to form a reaction tray main body. The nonmetallic heat shield 5 is used to ensure that the reaction plate body is at a constant temperature, since the reaction plate body needs to be at a constant temperature, preventing heat transfer. The reaction plate body is arranged in a closed space formed by the heat preservation cavity 6 and the heat preservation cover 7. The upper surface of the support plate 17 is uniformly distributed with temperature sensor wiring grooves 171. In this embodiment, four temperature sensor wiring grooves 171 are formed on the diameter of the intersection of the two disk bodies 1. The wiring groove 171 extends in the radial direction of the disk body 1. The outer surface of the enclosing wall 15 is formed with temperature sensor mounting holes 161 extending toward the inside of the step 16, and each of the temperature sensor mounting holes 161 and one of the temperature sensor wiring grooves 171 communicate to form a passage having an L-shaped cross section. In order to improve the accuracy of the temperature sensor, among the four temperature sensor wiring grooves 171, one calibration temperature sensor wiring groove 172 is disposed between adjacent temperature sensor wiring grooves 171, and correspondingly, the calibration temperature sensor mounting hole 162 is disposed between adjacent temperature sensor mounting holes 161. One temperature sensor mounting hole 162 communicates with one temperature sensor wiring groove 172 to form a passage having an L-shaped cross section. The upper surface of the support plate 17 is provided with an overheat protection sensor mounting groove 18 for mounting an overheat protection sensor.

Referring to fig. 3, the retainer 2 has a hollow cylindrical shape, and in this embodiment, the retainer 2 is formed by connecting multiple segments of protection plates 21 end to end.

Referring to fig. 7 and 8 in combination with fig. 1 and 2, the bottom ring 3 includes a bottom wall 31, an outer wall 32, and an inner wall 33. The outer wall 32, the inner wall 33 and the bottom wall 31 enclose a slot 34. The bottom wall 31 is annular. The bottom wall 31 is provided with a bottom heating body mounting groove 311 on the outer surface thereof, and the bottom heating body mounting groove 311 is wound around the bottom wall 31 for one revolution. The outer wall 32 and the inner wall 33 are rounded around the side edges of the bottom wall 31, so that the slot 34 is circular. The outer wall 32 is provided with a plurality of first light holes 321, the inner wall 33 is provided with a plurality of second light holes 331, and each cuvette notch is communicated with one of the first light holes 321 and one of the second light holes 331 and is located on the same light path.

Referring to fig. 3 in combination with fig. 1 to 2 and fig. 4 to 8, the assembly relationship of the disc 1, the retainer 2 and the bottom ring 3 is briefly described as follows:

the insertion portion 122 of the notch 12 is inserted into the slot 34, the retainer 2 is fixed to the notch 12 and the bottom ring 3 is fixed to the bottom of the heat-insulating cavity 11 by screws, thereby the bottom surface 21 of the retainer 2 contacts the top surface of the outer wall 32, and the bottom surface 114 of the tray 1 contacts the top surface of the inner wall 33, so that the shielding member is connected to the notch 12 to shield the opening 13 and form a plurality of cuvette notches 123 with the notch 12. Each cuvette slot is surrounded by adjacent slit teeth 12, the part of the outer surface of the tray 1 between adjacent slit teeth 12, the part of the retainer 2 between adjacent slit teeth 12, and the part of the bottom ring 3 (in particular on the bottom wall 31) between adjacent slit teeth 12.

Referring to fig. 9 in combination with fig. 1 to 8, the shield in the above embodiment comprises a retainer 1 and a bottom ring 3, and the bottom ring 3 is surrounded by a bottom wall 31, an outer wall 32 and an inner wall 33. As a variation of this embodiment, the shutter may also be of the following construction: the shield includes a retainer and a bottom wall. The retainer is hollow cylindrical. The bottom wall is circular and can be understood as a circular arc plate. The height of the retainer 2, the height of the groove teeth 12 and the height of the tray 1 are equal, and the top surface 123 of each groove tooth 12 is flush with the top surface 113 of the tray 1, as shown in fig. 9. In this configuration, the shutter is connected to the slit, and the plurality of cuvette notches for blocking the opening and forming the slit include: the guard ring is connected with the side face of each groove tooth, and the bottom wall is connected with the bottom face of the groove tooth, the bottom face of the tray body and the bottom face of the guard ring. The lower part of the guard ring is provided with a plurality of first light holes, the lower part of the tray body is provided with a plurality of second light holes, and each cuvette notch is communicated with one first light hole and one second light hole and is positioned on the same light path. The retainer is integrally constructed with the bottom wall such that the retainer and the bottom wall are L-shaped in cross section.

On the other hand, the embodiment also discloses a full-automatic biochemical analyzer. The analytical instrument comprises a reaction disk of any one of the solid direct thermal structures described above. As to how the reaction disk is assembled with other components to form the analyzer, the prior art may be adopted, and detailed description is omitted.

In summary, the reaction plate of the present application has at least the following beneficial effects:

1. because the surface of the disk body is provided with a plurality of adjacent groove teeth, the adjacent groove teeth form openings, and the shielding piece shields the openings to form a plurality of cuvette notches, the processing difficulty of the cuvette notches is low, the cost is low and the structure is simple.

The foregoing description is only a preferred embodiment of the present application, and is not intended to limit the invention to the particular embodiment disclosed, but is not intended to limit the invention to the particular embodiment disclosed, as any and all modifications, equivalent to the above-described embodiment, may be made by one skilled in the art without departing from the scope of the invention.

Claims

1. A reaction disk with a solid direct heating structure is characterized by comprising a disk body and a shielding piece, wherein,

the tray body is hollow and cylindrical, the outer surface of the tray body is uniformly provided with groove teeth, the extending direction of each groove tooth is parallel to the axial direction of the tray body, and openings are formed between adjacent groove teeth;

the shielding piece is connected with the groove teeth and shields the opening to form a plurality of cuvette notches with the groove teeth;

the shielding piece comprises a retainer ring and a bottom ring, the bottom ring comprises a bottom wall, an outer wall and an inner wall, and the outer wall, the inner wall and the bottom wall enclose a slot;

the guard ring is hollow cylindrical;

the top surface of each groove tooth is flush with the top surface of the tray body, and the height value of each groove tooth is larger than that of the tray body so that each groove tooth is provided with an insertion part;

the shielding piece is connected with the groove teeth, shields the opening and is connected with the groove teeth to form a plurality of cuvette notches, and the shielding piece comprises: the insertion part is inserted into the slot, the bottom surface of the retainer is contacted with the outer wall, and the bottom surface of the tray body is contacted with the inner wall.

2. The reaction plate of claim 1, wherein the outer wall is provided with a plurality of first light holes, the inner wall is provided with a plurality of second light holes, and each notch of the cuvette is communicated with one of the first light holes and one of the second light holes and is located on the same light path.

3. The reaction plate of claim 1, wherein the shield comprises a retainer and a bottom wall, the retainer being hollow cylindrical; the bottom wall is in a circular ring shape;

the top surface of each groove tooth is flush with the top surface of the tray body, and the height value of each groove tooth is equal to the height value of the tray body;

the shielding piece is connected with the groove teeth, shields the opening and is connected with the groove teeth to form a plurality of cuvette notches, and the shielding piece comprises: the guard ring is connected with the side face of each groove tooth, and the bottom wall is connected with the bottom face of the groove tooth, the bottom face of the tray body and the bottom face of the guard ring.

4. The reaction plate of claim 3, wherein a plurality of first light holes are formed in the lower portion of the guard ring, a plurality of second light holes are formed in the lower portion of the plate body, and each of the cuvette notches is communicated with one of the first light holes and one of the second light holes and is located on the same light path.

5. A reaction plate of a solid direct thermal construction according to claim 3 wherein the retainer and the bottom wall are integrally constructed.

6. A reaction plate of a solid state direct heating construction according to any one of claims 1 to 5 wherein the guard ring is formed from a plurality of segments of guard plates joined end to end.

7. A reaction plate of a solid direct thermal construction according to any one of claims 1 to 5, wherein the inner surface of the plate body is provided with side heating body mounting grooves which are provided around the inner surface of the plate body for one revolution.

8. The reaction plate of claim 7, wherein the shielding member has a bottom wall, the bottom wall is circular, a bottom heating body mounting groove is formed in the outer surface of the bottom wall, and the bottom heating body mounting groove surrounds the bottom wall for a circle.

9. A reaction tray of a solid direct thermal construction according to any one of claims 1 to 5 wherein the top surface of the tray body is provided with a perimeter wall which surrounds the tray body around a circumference and has a diameter which is smaller than the diameter of the tray body and forms a step with the tray body.

10. The reaction plate of the solid direct heating structure according to claim 9, wherein the reaction plate comprises a support plate, the support plate extends along the radial direction of the plate body and is connected with the enclosing wall, and the upper surface of the support plate is uniformly distributed with temperature sensor wiring grooves;

the outside surface of enclosure is formed with the temperature sensor mounting hole that extends to the step is inside, and every temperature sensor mounting hole and a temperature sensor wiring groove intercommunication constitutes the passageway that the cross-section was L shape.

11. The reaction plate of claim 10, wherein one calibration temperature sensor wiring groove is disposed between adjacent temperature sensor wiring grooves, one calibration temperature sensor mounting hole is disposed between adjacent temperature sensor mounting holes, and the calibration temperature sensor mounting hole and the calibration temperature sensor wiring groove are communicated to form a channel with an L-shaped cross section.

12. The reaction plate of claim 9, wherein the reaction plate comprises a support plate extending in a radial direction of the plate body and connected to the enclosure wall, and an upper surface of the support plate is provided with an overheat protection sensor mounting groove.

13. A fully automatic biochemical analyzer, characterized in that it comprises a reaction disc of solid direct thermal structure according to any one of claims 1 to 12.