CN109142345A - A kind of accurate medical treatment detection device of autoimmunity disease - Google Patents

A kind of accurate medical treatment detection device of autoimmunity disease Download PDF

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Publication number
CN109142345A
CN109142345A CN201811187807.5A CN201811187807A CN109142345A CN 109142345 A CN109142345 A CN 109142345A CN 201811187807 A CN201811187807 A CN 201811187807A CN 109142345 A CN109142345 A CN 109142345A
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CN
China
Prior art keywords
cuvette
reaction tray
hole
medical treatment
detection device
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Pending
Application number
CN201811187807.5A
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Chinese (zh)
Inventor
石彬
陈先恋
张敏敏
彭志元
郑国波
胡永林
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Affiliated Hospital of Zunyi Medical University
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Affiliated Hospital of Zunyi Medical University
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Priority to CN201811187807.5A priority Critical patent/CN109142345A/en
Publication of CN109142345A publication Critical patent/CN109142345A/en
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention discloses a kind of accurate medical treatment detection devices of autoimmunity disease, including automatic clinical chemistry analyzer, automatic clinical chemistry analyzer includes ontology, sample disc, sampler, reagent position, cuvette and reaction tray, several cuvettes and connector form cricoid cuvette group, connector is located at the upper section of cuvette, the upper surface of inner wall of cuvette group is equipped with link block, through-hole is equipped with above link block, reaction tray is disc, the outer edge of the upper surface of reaction tray is set as step, the step of cuvette group and reaction tray matches, the reaction tray for being correspondingly connected with the through hole of block is equipped with and connect block-shaped identical link slot, screw hole corresponding with through-hole is equipped in link slot, cuvette group is screwed at the screw hole for being connected to reaction tray by the through-hole on link block, it solves contact accuracy between existing cuvette and reaction tray to reach The problem of less than requiring, improves the accuracy of testing result.

Description

A kind of accurate medical treatment detection device of autoimmunity disease
Technical field
The invention belongs to technical field of medical equipment, the precision medical treatment detection more particularly to a kind of autoimmunity disease is set It is standby.
Background technique
Autoimmune disease refers to that body occurs immune response to autoantigen and causes caused by damaged self tissue Disease.Many diseases are listed in autoimmune disease in succession, it is worth mentioning that, the presence and autoimmunity of autoantibody Property disease is not two equivalent concepts, and the normal person that autoantibody may be present in no autoimmune disease is especially old People, such as anti-thyroglobulin antibody, Thyroid follicular epithelial cell antibody, gastric parietal cell antibody, nucleus DNA antibody.Sometimes, The impaired or changed tissue of antigenicity can excite the generation of autoantibody, and when such as myocardial ischemia, downright bad cardiac muscle be can lead to Anti-myocardium autoantibody is formed, but this antibody has no pathogenic effects, is a kind of secondary immune response.
It is all with automatic clinical chemistry analyzer for main detection to the accurate medical treatment detection device of autoimmunity disease now Equipment is analyzed by the blood to patient, judges the difference of patient's indices and normal value, to autoimmunity disease illness Situation compares and analyzes, but the cuvette of existing automatic clinical chemistry analyzer be when in use by rim of a cup circular arc, The flange in outside is contacted with reaction tray peripheral groove trough rim makees vertical direction positioning, by between the shape and groove of cuvette Cooperation precision makees horizontal direction positioning contrastive colours cup, reaction tray groove and the assembly precision requirement height between them, increases system This is caused, and the assembly precision between them is difficult to ensure, is easy to make the optical surface of the center deviation cuvette lower part of the light velocity Center influences the accuracy of measurement.Such as: in the patent that Chinese Patent Application No. is 201120281248.1, disclose one kind The reaction tray driving mechanism of automatic clinical chemistry analyzer, including " bracket, driving motor, pinion gear, transmission gear, toothed disc, branch Support column, bearing, bearing fixing sleeve, reaction tray connector, reaction tray and reaction tray locking lid composition " be difficult to ensure cuvette with The assembling accuracy contacted between reaction tray.
Therefore, the emphasis how to solve the above problems as those skilled in the art's research.
Summary of the invention
It is an object of the invention to provide a kind of accurate medical treatment detection devices of autoimmunity disease, can effectively solve above-mentioned difficulty To guarantee the shortcoming of the assembling accuracy contacted between cuvette and reaction tray.
The purpose of the present invention is realized by following technical proposals:
A kind of accurate medical treatment detection device of autoimmunity disease, including automatic clinical chemistry analyzer, full-automatic biochemical analysis Instrument includes ontology, sample disc, sampler, reagent position, cuvette and reaction tray, and several cuvettes and connector composition are cricoid Cuvette group, the connector are located at the upper section of cuvette, and the upper surface of inner wall of the cuvette group is equipped with link block, the company It connects and is equipped with through-hole above block, the reaction tray is disc, and the outer edge of the upper surface of reaction tray is set as step, cuvette group and anti- The step that should be coiled matches, and the reaction tray for being correspondingly connected with the through hole of block is equipped with and connect block-shaped identical link slot, even Screw hole corresponding with through-hole is equipped in access slot, cuvette group is screwed by the through-hole on link block and is connected to reaction tray At screw hole.
Preferably, the center of the reaction tray is equipped with locating piece, the center of the locating piece is equipped with mounting hole, reaction tray It is set on the body by mounting hole.
Preferably, being equipped with through slot inside the reaction tray.
Preferably, the through slot is uniformly arranged four.
Preferably, the link block is respectively arranged one in the upper and lower, left and right of cuvette group, each link block is equipped with Three through-holes.
Preferably, the sampler includes sampling probe, the sampling wire surface sprays Nano self-cleaning coating.
Preferably, being equipped with the hole that can accommodate different size blood sampling test tube in the sample disc.
Preferably, the reagent position is equipped with independent cold storage plant.
Compared with prior art, the beneficial effects of the present invention are:
The present invention solves the problems, such as that accuracy is contacted between existing cuvette and reaction tray not to be reached requirement, and inspection is improved The accuracy for surveying result also solves the problems, such as that reaction tray and cuvette have inconvenience in terms of handling, positioning, cleaning.
Detailed description of the invention
Fig. 1 is cuvette group structural schematic diagram;
Fig. 2 is bulk junction composition;
Fig. 3 is that reaction tray with cuvette connect top view;
Fig. 4 is that reaction tray with cuvette connect front view;
Fig. 5 is cuvette group top view;
Fig. 6 is cuvette group front view;
Fig. 7 is reaction tray top view;
Fig. 8 is reaction tray front view;
Fig. 9 is reaction tray structure chart.
Description of symbols: 1- ontology, 2- sample disc, 3- sampler, 4- reagent position, 5- cuvette, 6- reaction tray, 7- Sample needle, 8- cuvette group, 9- step, 10- link block, 11- through-hole, 12- screw hole, 13- locating piece, 14- mounting hole, 15- are logical Slot, 16- screw, 17- link slot, 18- connector.
Specific embodiment
The present invention is further illustrated with attached drawing combined with specific embodiments below.
Embodiment one
As shown in Figures 1 to 9, the accurate medical treatment detection device of a kind of autoimmunity disease, including automatic clinical chemistry analyzer, Automatic clinical chemistry analyzer includes ontology 1, sample disc 2, sampler 3, reagent position 4, cuvette 5 and reaction tray 6, and ontology 1 is adopted Inspire confidence in the ontology of HF240-300 automatic clinical chemistry analyzer with Hai Li, several cuvettes 5 and connector 18 form cricoid cuvette Group 8, the connector 18 are located at the upper section of cuvette 5, and the upper surface of inner wall of the cuvette group 8 is equipped with link block 10, described Link block 10 is equipped with through-hole 11 above, and link block 10 is respectively arranged one in the upper and lower, left and right of cuvette group 8, each link block It is set on 10 there are three through-hole, the reaction tray 6 is disc, and the outer edge of the upper surface of reaction tray 6 is set as step 9, cuvette group 8 Matching with the step 9 of reaction tray 6, cuvette group 8 can be embedded just below on the step of reaction tray 6, it is completely coincident with step 9, It is correspondingly connected with the reaction tray 6 at the through-hole 11 of block 10 to be equipped with and connect block-shaped identical link slot 17, be set in link slot 17 There is screw hole 12 corresponding with through-hole, cuvette group 8 is fixedly connected on reaction tray 6 with screw 16 by the through-hole 11 on link block 10 Screw hole 12 at, the center of reaction tray is equipped with locating piece, and the center of locating piece is equipped with mounting hole, and reaction tray is located at by mounting hole On ontology, by the cooperation of cuvette group and step 9, in addition through-hole and the screw hole 12 fixed cuvette and anti-of reducing of screw 16 The manufacture difficulty and cost that should be coiled, cuvette are made of organic glass, and organic glass surface is coated with one layer of vacuum electric coating, very Dummy plating layer is made of silica coating, fluorocarbons layer and polymeric layer, silica coating 30-70nm, fluorine For carbon compound layer with a thickness of 20-60nm, polymeric layer at least contains polycarbonate (PC) and polymethyl methacrylate (PMMA), Polymer layer of thickness is 30-70nm, is laminated each other between each layer of vacuum electric coating using thermoplastic interlayer, thermoplastic interlayer With a thickness of 2-10nm, the preferred silica coating of the present embodiment is 50nm, and fluorocarbons layer is with a thickness of 40nm, polymer thickness Degree is 30nm, and thermoplastic interlayer is bonded with a thickness of 5nm, any of the above layer by adhesive layer, and it is viscous that adhesive layer contains chemosetting Agent is connect, the preferred bonding agent of the present embodiment is silicone adhesive bonding agent, and vacuum electric coating enhances the hardness of cuvette, and improves surface Smooth degree and light transmittance, thermoplastic interlayer have noise reduction effect, cuvette outermost layer increase by one layer of ink layer.
In the present embodiment, cuvette group is that an entirety is embedded on the step of reaction tray, contacts cuvette and reaction tray The precise requirements at place reduce, and improve the accuracy of testing result.
Embodiment two
As shown in Figures 1 to 9, the accurate medical treatment detection device of a kind of autoimmunity disease, including automatic clinical chemistry analyzer, Automatic clinical chemistry analyzer includes ontology 1, sample disc 2, sampler 3, reagent position 4, cuvette 5 and reaction tray 6, and ontology 1 is adopted Inspire confidence in the ontology of HF240-300 automatic clinical chemistry analyzer with Hai Li, several cuvettes 5 and connector 18 form cricoid cuvette Group 8, the connector 18 are located at the upper section of cuvette 5, and the upper surface of inner wall of the cuvette group 8 is equipped with link block 10, described Link block 10 is equipped with through-hole 11 above, and link block 10 is respectively arranged one in the upper and lower, left and right of cuvette group 8, each link block It is set on 10 there are three through-hole, the reaction tray 6 is disc, and the outer edge of the upper surface of reaction tray 6 is set as step 9, cuvette group 8 Matching with the step 9 of reaction tray 6, cuvette group 8 can be embedded just below on the step of reaction tray 6, it is completely coincident with step 9, It is correspondingly connected with the reaction tray 6 at the through-hole 11 of block 10 to be equipped with and connect block-shaped identical link slot 17, be set in link slot 17 There is screw hole 12 corresponding with through-hole, cuvette group 8 is fixedly connected on reaction tray 6 with screw 16 by the through-hole 11 on link block 10 Screw hole 12 at, the center of reaction tray is equipped with locating piece, and the center of locating piece is equipped with mounting hole, and reaction tray is located at by mounting hole On ontology, by the cooperation of cuvette group and step 9, in addition through-hole and the screw hole 12 fixed cuvette and anti-of reducing of screw 16 The manufacture difficulty and cost that should be coiled, cuvette are made of organic glass, and organic glass surface is coated with one layer of vacuum electric coating, very Dummy plating layer is made of silica coating and fluorocarbons layer, silica coating 50nm, fluorocarbons thickness Degree is 40nm, and vacuum electric coating enhances the hardness of cuvette, and improves the smooth degree and light transmittance on surface, and cuvette is outermost Layer increases by one layer of ink layer, is equipped with through slot 15 inside reaction tray 6, and through slot 15 is uniformly arranged four in reaction tray 6, reaction tray A through slot is respectively arranged in upper and lower, left and right inside 6, and the size of through slot 15 can just pass through a finger.
In the present embodiment, through slot is set inside reaction tray when picking and placing reaction tray, facilitates staff to hold steadily, together When it is also easy to clean.
Embodiment three
As shown in Figures 1 to 9, the accurate medical treatment detection device of a kind of autoimmunity disease, including automatic clinical chemistry analyzer, Automatic clinical chemistry analyzer includes ontology 1, sample disc 2, sampler 3, reagent position 4, cuvette 5 and reaction tray 6, and ontology 1 is adopted Inspire confidence in the ontology of HF240-300 automatic clinical chemistry analyzer with Hai Li, several cuvettes 5 and connector 18 form cricoid cuvette Group 8, the connector 18 are located at the upper section of cuvette 5, and the upper surface of inner wall of the cuvette group 8 is equipped with link block 10, described Link block 10 is equipped with through-hole 11 above, and link block 10 is respectively arranged one in the upper and lower, left and right of cuvette group 8, each link block It is set on 10 there are three through-hole, the reaction tray 6 is disc, and the outer edge of the upper surface of reaction tray 6 is set as step 9, cuvette group 8 Matching with the step 9 of reaction tray 6, cuvette group 8 can be embedded just below on the step of reaction tray 6, it is completely coincident with step 9, It is correspondingly connected with the reaction tray 6 at the through-hole 11 of block 10 to be equipped with and connect block-shaped identical link slot 17, be set in link slot 17 There is screw hole 12 corresponding with through-hole, cuvette group 8 is fixedly connected on reaction tray 6 with screw 16 by the through-hole 11 on link block 10 Screw hole 12 at, the center of reaction tray is equipped with locating piece, and the center of locating piece is equipped with mounting hole, and reaction tray is located at by mounting hole On ontology, by the cooperation of cuvette group and step 9, in addition through-hole and the screw hole 12 fixed cuvette and anti-of reducing of screw 16 The manufacture difficulty and cost that should be coiled, cuvette are made of organic glass, and organic glass surface is coated with one layer of vacuum electric coating, very Dummy plating layer is made of silica coating and fluorocarbons layer, silica coating 50nm, fluorocarbons thickness Degree is 40nm, and vacuum electric coating enhances the hardness of cuvette, and improves the smooth degree and light transmittance on surface, and cuvette is outermost Layer increases by one layer of ink layer, and sampler 3 includes sampling probe 7, and 7 surface of sampling probe sprays Nano self-cleaning coating.
In the present embodiment, Nano self-cleaning material can not only make film surface absorption pollutant occur redox decompose and Surface germ is removed and killed, achievees the purpose that self-cleaning, avoids that cross contamination occurs between different sample liquid.
Example IV
As shown in Figures 1 to 9, the accurate medical treatment detection device of a kind of autoimmunity disease, including automatic clinical chemistry analyzer, Automatic clinical chemistry analyzer includes ontology 1, sample disc 2, sampler 3, reagent position 4, cuvette 5 and reaction tray 6, and ontology 1 is adopted Inspire confidence in the ontology of HF240-300 automatic clinical chemistry analyzer with Hai Li, several cuvettes 5 and connector 18 form cricoid cuvette Group 8, the connector 18 are located at the upper section of cuvette 5, and the upper surface of inner wall of the cuvette group 8 is equipped with link block 10, described Link block 10 is equipped with through-hole 11 above, and link block 10 is respectively arranged one in the upper and lower, left and right of cuvette group 8, each link block It is set on 10 there are three through-hole, the reaction tray 6 is disc, and the outer edge of the upper surface of reaction tray 6 is set as step 9, cuvette group 8 Matching with the step 9 of reaction tray 6, cuvette group 8 can be embedded just below on the step of reaction tray 6, it is completely coincident with step 9, It is correspondingly connected with the reaction tray 6 at the through-hole 11 of block 10 to be equipped with and connect block-shaped identical link slot 17, be set in link slot 17 There is screw hole 12 corresponding with through-hole, cuvette group 8 is fixedly connected on reaction tray 6 with screw 16 by the through-hole 11 on link block 10 Screw hole 12 at, the center of reaction tray is equipped with locating piece, and the center of locating piece is equipped with mounting hole, and reaction tray is located at by mounting hole On ontology, by the cooperation of cuvette group and step 9, in addition through-hole and the screw hole 12 fixed cuvette and anti-of reducing of screw 16 The manufacture difficulty and cost that should be coiled, cuvette are made of organic glass, and organic glass surface is coated with one layer of vacuum electric coating, very Dummy plating layer is made of silica coating and fluorocarbons layer, silica coating 50nm, fluorocarbons thickness Degree is 40nm, and vacuum electric coating enhances the hardness of cuvette, and improves the smooth degree and light transmittance on surface, and cuvette is outermost Layer increases by one layer of ink layer, and the hole that can accommodate different size blood sampling test tube is equipped in sample disc 2, and reagent position 4 is equipped with independent Cold storage plant.
In the present embodiment, the sky of sample disc setting different size makes it possible to accommodate a greater variety of sampling pipes and blood sampling examination Pipe, independent cold storage plant, which is arranged, in reagent position to need different samples carrying out different condition according to the refrigeration of different samples Refrigeration.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.

Claims (8)

1. a kind of accurate medical treatment detection device of autoimmunity disease, including automatic clinical chemistry analyzer, automatic clinical chemistry analyzer Including ontology (1), sample disc (2), sampler (3), reagent position (4), cuvette (5) and reaction tray (6), it is characterised in that: Several cuvettes (5) and connector (18) form cricoid cuvette group (8), and the connector (18) is located at cuvette (5) Upper section, the upper surface of inner wall of the cuvette group (8) are equipped with link block (10), and the link block (10) is equipped with through-hole above (11), the reaction tray (6) is disc, and the outer edge of the upper surface of reaction tray (6) is set as step (9), cuvette group (8) and anti- The step (9) that (6) should be coiled matches, and is correspondingly connected with the reaction tray (6) at the through-hole (11) of block (10) and is equipped with and link block shape The identical link slot of shape (17), link slot (17) is interior to be equipped with screw hole (12) corresponding with through-hole, and cuvette group (8) passes through link block (10) through-hole (11) on is fixedly connected at the screw hole (12) of reaction tray (6) with screw (16).
2. a kind of accurate medical treatment detection device of autoimmunity disease according to claim 1, it is characterised in that: the reaction The center of disk (6) is equipped with locating piece (13), and the center of the locating piece (13) is equipped with mounting hole (14), and reaction tray (6) passes through peace Dress hole (14) is located on ontology (1).
3. a kind of accurate medical treatment detection device of autoimmunity disease according to claim 1, it is characterised in that: the reaction Through slot (15) are equipped with inside disk (6).
4. a kind of accurate medical treatment detection device of autoimmunity disease according to claim 3, it is characterised in that: the through slot (15) four are uniformly arranged.
5. a kind of accurate medical treatment detection device of autoimmunity disease according to claim 1, it is characterised in that: the connection Block (10) is respectively arranged one in the upper and lower, left and right of cuvette group (8), is set on each link block (10) there are three through-hole.
6. a kind of accurate medical treatment detection device of autoimmunity disease according to claim 1, it is characterised in that: the sampling Device (3) includes sampling probe (7), and sampling probe (7) surface sprays Nano self-cleaning coating.
7. a kind of accurate medical treatment detection device of autoimmunity disease according to claim 1, it is characterised in that: the sample The hole that can accommodate different size blood sampling test tube is equipped in disk (2).
8. a kind of accurate medical treatment detection device of autoimmunity disease according to claim 1, it is characterised in that: the reagent Position (4) is equipped with independent cold storage plant.
CN201811187807.5A 2018-10-12 2018-10-12 A kind of accurate medical treatment detection device of autoimmunity disease Pending CN109142345A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110376393A (en) * 2019-08-21 2019-10-25 东软威特曼生物科技(沈阳)有限公司 The reaction tray and its automatic clinical chemistry analyzer of solid directly-heated structure

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US20070134135A1 (en) * 2005-12-12 2007-06-14 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Disposable Reaction Cuvette Segment for Use in Full Automatic Chemistry Analyzers
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CN203672890U (en) * 2013-12-27 2014-06-25 金华市强盛生物科技有限公司 Small-sized full-automatic biochemical analyzer
CN204882364U (en) * 2015-09-08 2015-12-16 宁波美康盛德生物科技有限公司 Cell transmittance tester
CN205263108U (en) * 2015-12-14 2016-05-25 重庆博士泰生物技术有限公司 Full -automatic specific protein analyzer reaction plate
CN107860935A (en) * 2017-12-31 2018-03-30 珠海森龙生物科技有限公司 High-speed full-automatic Biochemical Analyzer directly-heated reacts disk module
CN208872673U (en) * 2018-10-12 2019-05-17 遵义医学院附属医院 A kind of accurate medical treatment detection device of autoimmunity disease

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Publication number Priority date Publication date Assignee Title
US20070134135A1 (en) * 2005-12-12 2007-06-14 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Disposable Reaction Cuvette Segment for Use in Full Automatic Chemistry Analyzers
CN201637748U (en) * 2010-01-13 2010-11-17 上海科华实验系统有限公司 Cuvette combination for full-automatic biochemical analyzer
CN203672890U (en) * 2013-12-27 2014-06-25 金华市强盛生物科技有限公司 Small-sized full-automatic biochemical analyzer
CN204882364U (en) * 2015-09-08 2015-12-16 宁波美康盛德生物科技有限公司 Cell transmittance tester
CN205263108U (en) * 2015-12-14 2016-05-25 重庆博士泰生物技术有限公司 Full -automatic specific protein analyzer reaction plate
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110376393A (en) * 2019-08-21 2019-10-25 东软威特曼生物科技(沈阳)有限公司 The reaction tray and its automatic clinical chemistry analyzer of solid directly-heated structure
CN110376393B (en) * 2019-08-21 2023-05-30 东软威特曼生物科技(沈阳)有限公司 Reaction disc with solid direct-heating structure and full-automatic biochemical analyzer thereof

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