CN110354027A - A kind of multi-functional lotion and preparation method thereof - Google Patents
A kind of multi-functional lotion and preparation method thereof Download PDFInfo
- Publication number
- CN110354027A CN110354027A CN201910804015.6A CN201910804015A CN110354027A CN 110354027 A CN110354027 A CN 110354027A CN 201910804015 A CN201910804015 A CN 201910804015A CN 110354027 A CN110354027 A CN 110354027A
- Authority
- CN
- China
- Prior art keywords
- parts
- vitamin
- lotion
- mixture
- functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of multi-functional lotions and preparation method thereof.The multi-functional lotion includes the raw material of following parts by weight: 0.45~1 part of vitamin E, 3.8~12.6 parts of glycerine, 3~10 parts of butanediol, 5~20 parts of castor oil, 80~120 parts of purified water, 1~4 part of hydrophilic titania powder and 0.5~2 part of oleophylic nano titanium dioxide powder.The preparation method is the following steps are included: S101, the vitamin E by multi-functional emulsion materials, castor oil, hydrophilic titania powder and oleophylic nano titanium dioxide powder are uniformly mixed, 15~25min is mixed using ultrasonic mixer, obtains the first mixture；S102, glycerine, butanediol and purified water are added in the first mixture, obtain the second mixture；S103, the second mixture is dispersed into 3~7min according to the revolving speed of 23000~25000rpm using high speed disperser；The speed of high speed disperser is adjusted to 19000~21000rpm again, continues to disperse second 18~25min of mixture to get multi-functional lotion is arrived.It is possible thereby to improve the stability of vitamin E and Transdermal absorption efficiency in lotion.
Description
Technical field
The present invention relates to technical field of skin care, and in particular, to a kind of multi-functional lotion and preparation method thereof.
Background technique
Skin water shortage and oxidation will cause many skin problems, such as acne, wrinkle, color spot, and skin will be caused when serious
Cancer.Therefore, skin moisturizing and it is anti-oxidant be the most basic function demand of skin care item.Meanwhile more and more researches show that, daylight
In ultraviolet light be also cause skin to be inflamed, immunosupress, light aging even cutaneum carcinoma an important factor for.Ultraviolet light irradiation
It will cause the big of the various reactive oxygen species (ROS) including superoxide radical, hydrogen peroxide, hydroxyl radical free radical and singlet oxygen etc.
Amount generates, to cause above-mentioned various skin injuries.Therefore, skin problem is fought, needs sunscreen-antioxidant-moisturizing multitube neat
Under.
Scientific investigations showed that antioxidant content can effectively remove free radical excessive in vivo, and assist a variety of enzymes in vivo
It has an effect to overcome skin disease and aging.Common natural has fat-soluble antioxidant dimension life in skin care item
Plain E has at present compared deeply the research of this this kind of vitamin.Vitamin E is also known as tocopherol, is a kind of liposoluble vitamin,
With stronger lipoid peroxidization resistant.Studies have found that body vitamin E intake and tumour negative correlation, but it is anti-
Cancer mechanism may include still among research and resist peroxide to the attack of cell membrane, the shape of inhibition carcinogen nitrosamine
At, block carcinogenic radical reaction, the activity for reducing Mutation induction substance etc..However, vitamin E have it is sensitive to light and heat,
The disadvantages such as easily oxidation, poorly water-soluble, bioavilability be low, limit its application.
1903, have scientist find solia particle can with stable emulsion, subsequent scientist Pickering to the phenomenon into
Go system research, it was demonstrated that ultra-fine solia particle can steadily be present in water/oil interface, play the role of stable emulsion,
Later this lotion is just named as " Pickering lotion ".Compared with the stable lotion of conventional surfactant,
Pickering lotion is with 2 clear superiorities: it is highly-safe 1. without the surfactant with certain toxic side effect, to ring
Border is friendly；2. solia particle film adsorbs almost irreversible, stability of emulsion in oil-water interfaces than molecule film thickness, solia particle
By force, it is not easy the influence of the factors such as receptor set occurrence, salinity, temperature and oily phase composition.Therefore, Pickering lotion was in recent years
It is paid close attention to by researcher, one for becoming the research fields such as physical chemistry, chemistry, material science, food, cosmetics, medicine is new
Hot spot.
Stability difference and the inefficient problem of Transdermal absorption for vitamin E in lotion, need to carry out existing lotion
Improve, with solve there is currently the technical issues of.
Summary of the invention
The object of the present invention is to provide a kind of lotions, to improve the stability of vitamin E and Transdermal absorption efficiency in lotion.
To achieve the goals above, the present invention provides a kind of multi-functional lotion, the raw material including following parts by weight: dimension life
Plain E0.45~1 part, 3.8~12.6 parts of glycerine, 3~10 parts of butanediol, 5~20 parts of castor oil, 80~120 parts of purified water, parent
1~4 part and 0.5~2 part of oleophylic nano titanium dioxide powder of water nano titanium dioxide powder.
Optionally, the raw material including following parts by weight: 0.5~0.9 part of vitamin E, 4~12 parts of glycerine, butanediol 3
~9 parts, 5~18 parts of castor oil, 85~115 parts of purified water, 1.5~3.5 parts of hydrophilic titania powder and oleophylic nanometer
0.7~1.8 part of titania powder.
Optionally, the raw material including following parts by weight: 0.6~0.85 part of vitamin E, 5~12 parts of glycerine, butanediol
3~8 parts, 5~15 parts of castor oil, 90~110 parts of purified water, 1.5~3 parts of hydrophilic titania powder and oleophylic nanometer two
0.7~1.5 part of titanium dioxide powder.
Optionally, the raw material including following parts by weight: 0.7~0.8 part of vitamin E, 6~10 parts of glycerine, butanediol 4
~7 parts, 8~12 parts of castor oil, 95~105 parts of purified water, 1.5~2.5 parts of hydrophilic titania powder and oleophylic nanometer
0.8~1.2 part of titania powder.
Optionally, the raw material including following parts by weight: 0.75 part of vitamin E, 8 parts of glycerine, 5 parts of butanediol, castor-oil plant
10 parts of oil, 100 parts of purified water, 2 parts of hydrophilic titania powder and 1 part of oleophylic nano titanium dioxide powder.
Present disclose provides a kind of preparation methods of multi-functional lotion, comprising the following steps:
S101, the vitamin E by multi-functional emulsion materials described above, castor oil, hydrophilic titanium dioxide powder
End and oleophylic nano titanium dioxide powder are uniformly mixed, and are mixed 15~25min using ultrasonic mixer, are obtained the first mixing
Object；
S102, glycerine, butanediol and purified water are added in the first mixture, obtain the second mixture；
S103, the second mixture is dispersed into 3~7min according to the revolving speed of 23000~25000rpm using high speed disperser；
The speed of high speed disperser is adjusted to 19000~21000rpm again, continues to disperse second 18~25min of mixture to get arriving
Multi-functional lotion.
Optionally, the mixing time of ultrasonic mixer is 20min.
Optionally, the second mixture is dispersed into 5min according to the revolving speed of 24000rpm using high speed disperser；It again will high speed
The speed of dispersion machine is adjusted to 20000rpm, continues to disperse the second mixture 20min.
Through the above technical solutions, multi-functional lotion obtained is free of surfactant, skin can effectively avoid to surface
The allergic phenomena of bioactive agent composition.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Simultaneously
Containing antioxidant content vitamin E, skin condition can be improved, effectively antagonize light skin light injury, it is dark to be beneficial to the improvement colour of skin
Heavy state.At the same time it can also improve the stability of vitamin E and Transdermal absorption efficiency in lotion, consequently facilitating skin absorbs
Moisture, to keep moisture state.
Other features and advantages of the present invention will the following detailed description will be given in the detailed implementation section.
Detailed description of the invention
The drawings are intended to provide a further understanding of the invention, and constitutes part of specification, with following tool
Body embodiment is used to explain the present invention together, but is not construed as limiting the invention.In the accompanying drawings:
Fig. 1 is the flow diagram of multi-functional emulsion preparation method in a kind of specific embodiment of disclosure offer；
Fig. 2 is the multi-functional lotion shape of multi-functional lotion under an optical microscope in a kind of embodiment of disclosure offer
State；
Fig. 3 is that the drop of multi-functional lotion under an optical microscope has the more of coloring agent in a kind of embodiment of disclosure offer
Functional latex, wherein coloring agent is the Sudan Ш dye liquor；
Fig. 4 is that the drop of multi-functional lotion under an optical microscope has the more of coloring agent in a kind of embodiment of disclosure offer
Functional latex, wherein coloring agent is methylenum careuleum dye liquor；
Fig. 5 be the disclosure provide a kind of embodiment in multi-functional lotion different oil-water ratio lotions naturally placement when
Stabilization number of days；
Fig. 6 is the accumulation infiltration capacity Q of multi-functional lotion in a kind of embodiment of disclosure offer.
Specific embodiment
Vitamin E (Vitamin E) is a kind of liposoluble vitamin, and hydrolysate is tocopherol, is most important anti-
One of oxidant.It is dissolved in the organic solvents such as fat and ethyl alcohol more, it is not soluble in water, heat, acid are stablized, it is unstable to alkali, to oxygen
Sensitivity, it is insensitive to heat, but Vitamin E activity is substantially reduced when frying.The molecular weight of vitamin E is C29H50O2, in the disclosure,
The relative density of vitamin E is 0.9g/cm3。
Castor oil is present in the seed of castor-oil plant, is the glyceryl ester of fatty acid, can softening skin, while mild moisturizing
Can also tender soft skin, have the effect of calm as mild as a dove, be particularly suitable for the skin of fatigue, pressure big people or quite sensitive,
The situation of skin sensitivity can be effectively reduced.The density of castor oil is 1.0g/cm3。
Glycerine is colourless sweet clear and bright thick liquid.It is odorless.There is warm sweet taste.It is commonly called as glycerol, tide can be absorbed from air
Gas can also absorb hydrogen sulfide, hydrogen cyanide and sulfur dioxide.It is insoluble in benzene, chloroform, carbon tetrachloride, carbon disulfide, petroleum ether and oil
Class.In the disclosure, the relative density 1.263g/cm of glycerine3, 17.8 DEG C of fusing point.
The English name of butanediol is: Butylene Glycol, since butanediol is small molecule moisturizing composition, so grabbing
Water ratio very little, while also having certain bacteriostasis.Wherein, the relative density of butanediol is 1.0g/cm3
Purified water is the water that hyoscine is made in the way of distillation, ion-exchange, hyperfiltration or other suitable methods, is free of
Any additives.Wherein, the density of pure water is 0.996g/cm3。
Embodiment will be enumerated below, and detailed description of the preferred embodiments.It should be understood that herein
Described specific embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
Embodiment 1
A kind of multi-functional lotion, the raw material including following parts by weight: 0.45 part of vitamin E, 3.8 parts of glycerine, fourth two
3 parts of alcohol, 5 parts of castor oil, 80 parts of purified water, 1 part of hydrophilic titania powder and oleophylic nano titanium dioxide powder 0.5
Part.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 2
A kind of multi-functional lotion, the raw material including following parts by weight: 0.5 part of vitamin E, 4.5 parts of glycerine, butanediol
4 parts, 7.5 parts of castor oil, 85 parts of purified water, 1.25 parts of hydrophilic titania powder and oleophylic nano titanium dioxide powder
0.75 part.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 3
A kind of multi-functional lotion, the raw material including following parts by weight: 0.55 part of vitamin E, 5 parts of glycerine, butanediol 5
Part, 9 parts of castor oil, 90 parts of purified water, 1.5 parts of hydrophilic titania powder and 0.9 part of oleophylic nano titanium dioxide powder.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 4
A kind of multi-functional lotion, the raw material including following parts by weight: 0.65 part of vitamin E, 6 parts of glycerine, butanediol 6
Part, 11 parts of castor oil, 95 parts of purified water, 1.75 parts of hydrophilic titania powder and 1 part of oleophylic nano titanium dioxide powder.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 5
A kind of multi-functional lotion, the raw material including following parts by weight: 0.75 part of vitamin E, 8 parts of glycerine, butanediol
5.5 parts, 12.5 parts of castor oil, 100 parts of purified water, 2.5 parts of hydrophilic titania powder and oleophylic nanometer titanium dioxide titanium valve
1.25 parts of end.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 6
A kind of multi-functional lotion, the raw material including following parts by weight: 0.8 part of vitamin E, 9 parts of glycerine, butanediol 7
Part, 14 parts of castor oil, 105 parts of purified water, 2.8 parts of hydrophilic titania powder and oleophylic nano titanium dioxide powder 1.4
Part.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 7
A kind of multi-functional lotion, the raw material including following parts by weight: 0.85 part of vitamin E, 10 parts of glycerine, butanediol
8 parts, 16 parts of castor oil, 110 parts of purified water, 3.2 parts of hydrophilic titania powder and oleophylic nano titanium dioxide powder 1.6
Part.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 8
A kind of multi-functional lotion, the raw material including following parts by weight: 0.9 part of vitamin E, 11 parts of glycerine, butanediol 9
Part, 18 parts of castor oil, 115 parts of purified water, 3.6 parts of hydrophilic titania powder and oleophylic nano titanium dioxide powder 1.8
Part.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 9
A kind of multi-functional lotion, the raw material including following parts by weight: vitamin e1 part, 12.6 parts of glycerine, butanediol
10 parts, 20 parts of castor oil, 120 parts of purified water, 4 parts of hydrophilic titania powder and 2 parts of oleophylic nano titanium dioxide powder.
Thus obtained multi-functional lotion is free of surfactant, can effectively avoid the mistake of skin Surfactant ingredient
Quick phenomenon.And since the lotion contains sun-prevention component, it can physically completely cut off ultraviolet light；Contain antioxidant content simultaneously
Vitamin E can improve skin condition, effectively antagonize light skin light injury, be beneficial to improve the obscure state of the colour of skin.Meanwhile
The stability of vitamin E and Transdermal absorption efficiency in lotion can also be improved, consequently facilitating skin absorbs moisture, to keep wet
State.
Embodiment 10
A kind of preparation method of multi-functional lotion, comprising the following steps:
S101, the vitamin E by multi-functional emulsion materials described in any one of embodiment 1 to embodiment 9, castor-oil plant
Oil, hydrophilic titania powder and oleophylic nano titanium dioxide powder are uniformly mixed, and are mixed using ultrasonic mixer
15min obtains the first mixture；
S102, glycerine, butanediol and purified water are added in the first mixture, obtain the second mixture；
S103, the second mixture is dispersed into 7min according to the revolving speed of 23000rpm using high speed disperser；Again by high speed point
The speed for dissipating machine is adjusted to 19000rpm, continues to disperse the second mixture 25min to get multi-functional lotion is arrived.
Thus the multi-functional lotion prepared is creamy white, and has certain viscosity.And the stabilization of vitamin E in lotion
Property good Transdermal absorption efficiency it is preferable, be not only advantageous for skin absorption, additionally it is possible to keep the moist degree of skin for a long time.
Embodiment 11
A kind of preparation method of multi-functional lotion, comprising the following steps:
S101, the vitamin E by multi-functional emulsion materials described in any one of embodiment 1 to embodiment 9, castor-oil plant
Oil, hydrophilic titania powder and oleophylic nano titanium dioxide powder are uniformly mixed, and are mixed using ultrasonic mixer
17min obtains the first mixture；
S102, glycerine, butanediol and purified water are added in the first mixture, obtain the second mixture；
S103, the second mixture is dispersed into 6min according to the revolving speed of 23500rpm using high speed disperser；Again by high speed point
The speed for dissipating machine is adjusted to 19500rpm, continues to disperse the second mixture 23min to get multi-functional lotion is arrived.
Thus the multi-functional lotion prepared is creamy white, and has certain viscosity.And the stabilization of vitamin E in lotion
Property good Transdermal absorption efficiency it is preferable, be not only advantageous for skin absorption, additionally it is possible to keep the moist degree of skin for a long time.
Embodiment 12
A kind of preparation method of multi-functional lotion, comprising the following steps:
S101, the vitamin E by multi-functional emulsion materials described in any one of embodiment 1 to embodiment 9, castor-oil plant
Oil, hydrophilic titania powder and oleophylic nano titanium dioxide powder are uniformly mixed, and are mixed using ultrasonic mixer
20min obtains the first mixture；
S102, glycerine, butanediol and purified water are added in the first mixture, obtain the second mixture；
S103, the second mixture is dispersed into 5min according to the revolving speed of 24000rpm using high speed disperser；Again by high speed point
The speed for dissipating machine is adjusted to 20000rpm, continues to disperse the second mixture 20min to get multi-functional lotion is arrived.
Thus the multi-functional lotion prepared is creamy white, and has certain viscosity.And the stabilization of vitamin E in lotion
Property good Transdermal absorption efficiency it is preferable, be not only advantageous for skin absorption, additionally it is possible to keep the moist degree of skin for a long time.
Embodiment 13
A kind of preparation method of multi-functional lotion, comprising the following steps:
S101, the vitamin E by multi-functional emulsion materials described in any one of embodiment 1 to embodiment 9, castor-oil plant
Oil, hydrophilic titania powder and oleophylic nano titanium dioxide powder are uniformly mixed, and are mixed using ultrasonic mixer
22min obtains the first mixture；
S102, glycerine, butanediol and purified water are added in the first mixture, obtain the second mixture；
S103, the second mixture is dispersed into 4min according to the revolving speed of 24500rpm using high speed disperser；Again by high speed point
The speed for dissipating machine is adjusted to 20500rpm, continues to disperse the second mixture 19min to get multi-functional lotion is arrived.
Thus the multi-functional lotion prepared is creamy white, and has certain viscosity.And the stabilization of vitamin E in lotion
Property good Transdermal absorption efficiency it is preferable, be not only advantageous for skin absorption, additionally it is possible to keep the moist degree of skin for a long time.
Embodiment 14
A kind of preparation method of multi-functional lotion, comprising the following steps:
S101, the vitamin E by multi-functional emulsion materials described in any one of embodiment 1 to embodiment 9, castor-oil plant
Oil, hydrophilic titania powder and oleophylic nano titanium dioxide powder are uniformly mixed, and are mixed using ultrasonic mixer
25min obtains the first mixture；
S102, glycerine, butanediol and purified water are added in the first mixture, obtain the second mixture；
S103, the second mixture is dispersed into 3min according to the revolving speed of 25000rpm using high speed disperser；Again by high speed point
The speed for dissipating machine is adjusted to 21000rpm, continues to disperse the second mixture 18min to get multi-functional lotion is arrived.
Thus the multi-functional lotion prepared is creamy white, and has certain viscosity.And the stabilization of vitamin E in lotion
Property good Transdermal absorption efficiency it is preferable, be not only advantageous for skin absorption, additionally it is possible to keep the moist degree of skin for a long time.
The multi-functional emulsion materials of parameter described in Example 5, should according to the preparation of preparation method described in embodiment 12
Multi-functional lotion, and morphologic observation, water contact angle measurement, emulsion types judgement, physical stability are carried out to obtained lotion
Measurement, content of vitamin E measurement and chemical stability measurement, vitamin E accumulate transdermal efficiency test, and obtained experimental result is such as
Shown in lower:
1) morphologic observation
As shown in Fig. 2, observation emulsion droplet is rounded and not of uniform size and evenly dispersed under an optical microscope.
2) water contact angle measurement
The measurement of 1 contact angle of table
| Pendulous frequency | State | Water contact angle |
| 1 | It sprawls | 77.2±3.0° |
| 2 | It sprawls | 78.1±2.5° |
| 3 | It sprawls | 77.5±3.0° |
Seen from table 1, it is 77.6 ± 2.6 ° that the water contact angle that lotion is measured, which is computed and is averaged, and water contact angle is small
In 90 °, it was demonstrated that the lotion liquid can moisten solid, and good hydrophilic property is O/W type lotion.
3) dyeing observation
As seen from Figure 3, red the Sudan Ш is dispersed in emulsion droplet, and medium is substantially colorless；From fig. 4, it can be seen that blue
Methylene blue is evenly dispersed with medium, and the indigo plant dye of emulsion droplet is shallower.By oil-soluble the Sudan Ш and water-soluble methylene blue
Characteristic distributions are it is found that the lotion of preparation is mutually scattered in the stable emulsion formed in water phase, i.e. emulsion oil-in-water in oil.
4) content of vitamin E measures
A certain amount of lotion is taken, its concentration is measured after handling by methodology validation method, is computed, vitamin E in lotion
Content be 40.00 ± 0.1 μ g/ml.
5) physical stability of lotion
As shown in figure 5, in further speeding up test, the lotion of preparation still not stratified, constant temperature after accelerating centrifugation 15min
Still not stratified after still not stratified after 60 DEG C of holding 60min, freezing 60min, every accelerated test is up to standard, is in stable state.
6) chemical stability of lotion
The content (μ g/ml) of 2 vitamin E of table
| Place number of days | Content of vitamin E in solution | Content of vitamin E in lotion |
| 0 | 40.05±0.3 | 40.07±0.1 |
| 7 | 37.46±0.1 | 39.71±0.2 |
| 14 | 35.92±0.1 | 38.44±0.1 |
7) Transdermal absorption of lotion
The average transdermal penetration concentration of the multi-functional lotion of table 3
The average transdermal penetration concentration trend of changing with time of multi-functional lotion is shown in Table 3.As can be seen that increasing at any time
Add, lotion osmotic concentration increases, and the concentration highest in 7h, concentration is gradually reduced later；And under equal ambient, same concentrations
Oil solution and aqueous solution osmotic concentration osmotic effect are below the osmotic concentration of lotion, that is, the osmotic effect of multi-functional lotion is most
It is good.
Accumulative infiltration capacity is calculated according to osmotic concentration and coefficient of permeability K, result are as shown in Figure 6.In Fig. 6, curve A table
Show the accumulation infiltration capacity of oil solution；The accumulation infiltration capacity of curve C expression aqueous solution；The accumulation infiltration capacity of curve D expression dairy industry.
From fig. 6, it can be seen that osmotic effect of the lotion (curve D) between 5-7h is best, infiltration is rapid.When 5h, lotion
Infiltration capacity can reach about 9.8 times of same concentrations oil solution (curve A), be 19.7 times of same concentrations aqueous solution (curve C)；
When 7h, it can reach 7.7 times of about oil solution, about the 20 of aqueous solution times；Although big not as infiltration rate is when 7h when 9h, but still
So in infiltration increase state, it can reach 7.3 times in about oil solution, 20.7 times of about aqueous solution, illustrate lotion Transdermal absorption
Effect is best compared to other.
In conclusion the multi-functional lotion of invention preparation has preferable physical stability, main component can be protected
Vitamin E is not degraded, and has the transdermal efficiency of preferable vitamin E.
It is described the prefered embodiments of the present invention in detail above in conjunction with attached drawing, still, the present invention is not limited to above-mentioned realities
The detail in mode is applied, within the scope of the technical concept of the present invention, a variety of letters can be carried out to technical solution of the present invention
Monotropic type, these simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, it can be combined in any appropriate way.In order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (8)
1. a kind of multi-functional lotion, which is characterized in that the raw material including following parts by weight: 0.45~1 part of vitamin E, the third three
3.8~12.6 parts of alcohol, 3~10 parts of butanediol, 5~20 parts of castor oil, 80~120 parts of purified water, hydrophilic titanium dioxide powder
1~4 part and 0.5~2 part of oleophylic nano titanium dioxide powder of end.
2. multi-functional lotion according to claim 1, which is characterized in that the raw material including following parts by weight: vitamin
E0.5~0.9 part, 4~12 parts of glycerine, 3~9 parts of butanediol, 5~18 parts of castor oil, 85~115 parts of purified water, hydrophilic
1.5~3.5 parts and 0.7~1.8 part of oleophylic nano titanium dioxide powder of titania powder.
3. multi-functional lotion according to claim 2, which is characterized in that the raw material including following parts by weight: vitamin
E0.6~0.85 part, 3~8 parts of butanediol, 5~15 parts of castor oil, 90~110 parts of purified water, hydrophilic is received 5~12 parts of glycerine
1.5~3 parts and 0.7~1.5 part of oleophylic nano titanium dioxide powder of rice titania powder.
4. multi-functional lotion according to claim 3, which is characterized in that the raw material including following parts by weight: vitamin
E0.7~0.8 part, 6~10 parts of glycerine, 4~7 parts of butanediol, 8~12 parts of castor oil, 95~105 parts of purified water, hydrophilic
1.5~2.5 parts and 0.8~1.2 part of oleophylic nano titanium dioxide powder of titania powder.
5. multi-functional lotion according to claim 4, which is characterized in that the raw material including following parts by weight: vitamin
E0.75 parts, 8 parts of glycerine, 5 parts of butanediol, 10 parts of castor oil, 100 parts of purified water, 2 parts of hydrophilic titania powder and
1 part of oleophylic nano titanium dioxide powder.
6. a kind of preparation method of multi-functional lotion, which comprises the following steps:
It is S101, the vitamin E by multi-functional emulsion materials described in any one of Claims 1 to 5, castor oil, hydrophilic
Nano titanium dioxide powder and oleophylic nano titanium dioxide powder are uniformly mixed, and mix 15~25min using ultrasonic mixer,
Obtain the first mixture；
S102, glycerine, butanediol and purified water are added in the first mixture, obtain the second mixture；
S103, the second mixture is dispersed into 3~7min according to the revolving speed of 23000~25000rpm using high speed disperser；Again will
The speed of high speed disperser is adjusted to 19000~21000rpm, continues to disperse second 18~25min of mixture to get more function are arrived
It can lotion.
7. the preparation method of multi-functional lotion according to claim 6, which is characterized in that when the mixing of ultrasonic mixer
Between be 20min.
8. the preparation method of multi-functional lotion according to claim 6, which is characterized in that use high speed disperser by second
Mixture disperses 5min according to the revolving speed of 24000rpm；The speed of high speed disperser is adjusted to 20000rpm again, continues to disperse
Second mixture 20min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910804015.6A CN110354027A (en) | 2019-08-28 | 2019-08-28 | A kind of multi-functional lotion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910804015.6A CN110354027A (en) | 2019-08-28 | 2019-08-28 | A kind of multi-functional lotion and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110354027A true CN110354027A (en) | 2019-10-22 |
Family
ID=68225444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910804015.6A Pending CN110354027A (en) | 2019-08-28 | 2019-08-28 | A kind of multi-functional lotion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110354027A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101677913A (en) * | 2007-05-10 | 2010-03-24 | 诺伊堡皮肤护理两合公司 | Surfactant-free foam formulations |
| WO2016124522A1 (en) * | 2015-02-02 | 2016-08-11 | Dsm Ip Assets B.V. | Pickering emulsions |
| TW201720414A (en) * | 2015-10-30 | 2017-06-16 | 愛茉莉太平洋股份有限公司 | Water-dispersible titanium dioxide composite powder and oil-in-water type cosmetic composition comprising the same |
| CN107802512A (en) * | 2017-12-07 | 2018-03-16 | 武汉大学 | A kind of vitamin E nano-emulsion, nanometer emulsifiable paste and preparation method thereof |
| CN109498486A (en) * | 2019-01-02 | 2019-03-22 | 江南大学 | A kind of amphipathic titanium dioxide emulsifier, Pickering lotion and its preparation method and application |
-
2019
- 2019-08-28 CN CN201910804015.6A patent/CN110354027A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101677913A (en) * | 2007-05-10 | 2010-03-24 | 诺伊堡皮肤护理两合公司 | Surfactant-free foam formulations |
| WO2016124522A1 (en) * | 2015-02-02 | 2016-08-11 | Dsm Ip Assets B.V. | Pickering emulsions |
| TW201720414A (en) * | 2015-10-30 | 2017-06-16 | 愛茉莉太平洋股份有限公司 | Water-dispersible titanium dioxide composite powder and oil-in-water type cosmetic composition comprising the same |
| CN107802512A (en) * | 2017-12-07 | 2018-03-16 | 武汉大学 | A kind of vitamin E nano-emulsion, nanometer emulsifiable paste and preparation method thereof |
| CN109498486A (en) * | 2019-01-02 | 2019-03-22 | 江南大学 | A kind of amphipathic titanium dioxide emulsifier, Pickering lotion and its preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100972777B1 (en) | Antioxidative composition and composition for external use | |
| Harwansh et al. | Nanoemulsions as vehicles for transdermal delivery of glycyrrhizin | |
| KR101547528B1 (en) | A water-in-oil pickering emulsion cosmetic composition and process of the preparation thereof | |
| TWI604856B (en) | In-water oil emulsion composition | |
| JP2001122765A (en) | Active oxygen scavenger and cosmetic | |
| JP6580018B2 (en) | Transparent lotion | |
| SK156494A3 (en) | Cosmetic agent containing phospholipids and fluorocarbon compounds | |
| CN101721322A (en) | Self tanning compositions containing dihydroxyacetone, a retinoid and ascorbic acid glucoside as a stabilizer | |
| NZ297736A (en) | Cosmetic composition containing kaolin and spherical particles of silicon dioxide or titanium dioxide | |
| FI107585B (en) | Preparations containing a fluorocarbon emulsion and useful as cosmetics and skin care agents | |
| Vaz et al. | Hesperetin loaded proposomal gel for topical antioxidant activity | |
| JPS63192705A (en) | External agent for skin | |
| CN114617785A (en) | Vesicle-type carrier and preparation method thereof, and cosmetic auxiliary material and preparation method thereof | |
| US5667772A (en) | Preparation containing a fluorocarbon emulsion and usable as cosmetics or dermatics | |
| KR20120039863A (en) | Nanoemulsion emulsifier and cosmetic composition comprising the same | |
| CN111417376B (en) | Transparent cosmetic composition | |
| CN113208942B (en) | Pterostilbene nanoemulsion as well as preparation method and application thereof | |
| JP6284303B2 (en) | O / W emulsion composition and external preparation for skin | |
| KR20170127165A (en) | Solid emulsion bead containing titanium dioxide and a cosmetic composition for skin whitening using the same | |
| CN110354027A (en) | A kind of multi-functional lotion and preparation method thereof | |
| JP5061984B2 (en) | Adapalene-containing external preparation composition | |
| JP5125122B2 (en) | Adapalene-containing external preparation composition | |
| CN115429713A (en) | Moisturizing, repairing and anti-aging composition containing ceramide and preparation method thereof | |
| CN107397687A (en) | A kind of oil-in-water cosmetic and preparation method containing melanin | |
| CN104546601A (en) | Long-lasting emulsion capable of effectively reducing ultraviolet ray absorption |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191022 |