CN110339364A - Lgr4/rspo阻断剂与抗免疫检查点抑制剂联合用于肿瘤的免疫治疗 - Google Patents
Lgr4/rspo阻断剂与抗免疫检查点抑制剂联合用于肿瘤的免疫治疗 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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PCT/CN2019/080480 WO2019192403A1 (zh) | 2018-04-02 | 2019-03-29 | Lgr4/rspo阻断剂与抗免疫检查点抑制剂联合用于肿瘤的免疫治疗 |
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CN104023746A (zh) * | 2011-07-15 | 2014-09-03 | 昂考梅德药品有限公司 | Rspo结合剂和其应用 |
CN104854132A (zh) * | 2012-07-13 | 2015-08-19 | 昂考梅德药品有限公司 | Rspo3结合剂及其用途 |
CN105985426A (zh) * | 2015-03-03 | 2016-10-05 | 华东师范大学 | Lgr4蛋白片段及其在制备治疗破骨细胞诱导的骨病的药物中的用途 |
WO2017040660A1 (en) * | 2015-08-31 | 2017-03-09 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
WO2017095918A2 (en) * | 2015-12-01 | 2017-06-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer using rspo3 antagonists |
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CN104023746A (zh) * | 2011-07-15 | 2014-09-03 | 昂考梅德药品有限公司 | Rspo结合剂和其应用 |
CN104854132A (zh) * | 2012-07-13 | 2015-08-19 | 昂考梅德药品有限公司 | Rspo3结合剂及其用途 |
CN105985426A (zh) * | 2015-03-03 | 2016-10-05 | 华东师范大学 | Lgr4蛋白片段及其在制备治疗破骨细胞诱导的骨病的药物中的用途 |
WO2017040660A1 (en) * | 2015-08-31 | 2017-03-09 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
WO2017095918A2 (en) * | 2015-12-01 | 2017-06-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer using rspo3 antagonists |
Non-Patent Citations (2)
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GUI-XUN SHI,等: "The Role of R-spondins and Their Receptors in Bone Metabolism", 《PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY》 * |
王冬立: "R-spondin家族蛋白与其受体相互作用的结构生物学研究", 《中国博士学位论文全文数据库》 * |
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Denomination of invention: Combination of LGR4/RSPO blockers and anti immune checkpoint inhibitors for immunotherapy of tumors Effective date of registration: 20231030 Granted publication date: 20210212 Pledgee: Minhang Branch of Shanghai Rural Commercial Bank Co.,Ltd. Pledgor: BIORAY LABORATORIES Inc. Registration number: Y2023310000689 |