CN110339084A - A kind of formula and preparation method thereof of the antibacterial essence of polypeptide compound acne-removing - Google Patents
A kind of formula and preparation method thereof of the antibacterial essence of polypeptide compound acne-removing Download PDFInfo
- Publication number
- CN110339084A CN110339084A CN201910805273.6A CN201910805273A CN110339084A CN 110339084 A CN110339084 A CN 110339084A CN 201910805273 A CN201910805273 A CN 201910805273A CN 110339084 A CN110339084 A CN 110339084A
- Authority
- CN
- China
- Prior art keywords
- acne
- parts
- peptide
- water
- essence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Abstract
The invention discloses a kind of antibacterial essences of polypeptide compound acne-removing, are prepared from the following materials: butanediol, biological carbohydrate gum -1, hamamelis flower water, ammonia sugar, perilla leaf extract, bacterium found peptide, arginine/lysine polypeptide, anti-acne peptide, folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1), parahydroxyacet-ophenone, Sodium Hyaluronate, dipotassium glycyrrhizinate, allantoin, xanthan gum, EDETATE SODIUM and water.This product mainly founds peptide as primary efficacy object using bacterium, and mild antibiotic effectively eliminates the basic source of small pox；It adds dipotassium glycyrrhizinate and arginine/lysine polypeptide accelerates the elimination of inflammation, accelerate the elimination of illness；To the north of the plant extracts such as U.S. dollar thread plum blossom water, perilla leaf extract be auxiliary, while inhibiting propionibacterium acnes growth, the excessive secretion of skin oil and fat can be inhibited, to prevent the generation again of small pox.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of formula of the antibacterial essence of polypeptide compound acne-removing and its preparation
Method.
Background technique
With the development of society, improvement of living standard, the anti-acne consciousness of the whelk patient of our countries improves year by year.
Chinese skin disease association, the joint investigation of adolescents in China federation are the results show that the disease incidence of China's whelk is in rise year by year
The problem of trend, 80% or more young people encounters whelk to some extent.The state of an illness it is more serious account for the 1/3 of young people with
On.
Acne is being commonly called as acne, is called " whelk ", " dark sore " or " acne ", is due to hair follicle and sebum adenemphraxis, hair
A kind of skin disease that inflammation is caused.When puberty, intracorporal hormone can stimulate hair growth, promote smegma more heavy wool
Therefore rouge, hair and sebaceous glands accumulate many substances, since this symptom is common in youth of both sexes, so just it is referred to as " the youth
Acne ".Small pox is a kind of chronic inflammatory skin at pilosebaceous follicle position, is mainly in the positions such as face, back, front.Skin
Rouge hypersecretion causes pilosebaceous duct to block, and the propionibacterium acnes on skin belong to typical gram-positive bacteria,
Using sebum as nutrition in the environment of anaerobism, excessive multiplication causes scytitis to react, and generates small pox.The generation and acne of small pox
The problems such as print, can generate adverse effect to human face's appearance.
Whelk is a kind of common chronic dermatosis, and juvenile onset number highest is mainly in face and chest and back, table
It is now blackhead, papule, the various skin injuries such as running sore, tumour and scar hinder appearance.The main reason of whelk is due to skin
The accumulation of matter causes clogging of pores that sebum is caused to accumulate the acne to be formed, once infection occur will occur in a short period of time
Deterioration forms serious tumour either abscess.
Acne itself is not fearful, and maximum harm is not in time or acne print, acne hole, acne are easily left in irregular treatment
Scar seriously affects image.Acne hole, which is really inflammation invasion, squeezes the equivalent damage epidermis of skin plus with hand, skin corium and more
For the subcutaneous tissue of lower section, the generation of the destruction of skin, the defect of tissue and scar is caused.These problems not only seriously affect outer
It sees, also acquires a certain degree of difficulty in the treatment.
So for small pox crowd, it is a in addition to paying attention to diet, living habit in order to completely remove acne print
Safely and effectively the antibacterial product of anti-acne is essential.
Summary of the invention
A kind of acne removal stock liquid is provided it is an object of the invention to overcome the shortcomings of the prior art place.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of antibacterial essence of polypeptide compound acne-removing, by with
The raw material of lower parts by weight is made: 70~85 parts of water, 1~10 part of butanediol, biological -1 1~8 part of carbohydrate gum, hamamelis flower water 1
~8 parts, 1~5 part of ammonia sugar, 1~4 part of purple perilla (PERILLA OCYMOIDES) leaf extract, bacterium stand 0.5~4 part of peptide, arginine/
0.5~3 part of lysine polypeptide, 0.5~3 part of anti-acne peptide, 0.1~2 part of folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol octanoic acid
Ester=1:2:1) 0.1~0.8 part, 0.1~0.5 part of parahydroxyacet-ophenone, 0.05~0.3 part of Sodium Hyaluronate, dipotassium glycyrrhizinate
0.01~0.3 part, 0.05~0.3 part of allantoin, 0.01~0.1 part of xanthan gum, 0.01~0.1 part of EDETATE SODIUM.
Preferably, the antibacterial essence of polypeptide compound acne-removing, is made: water 80~83 by the raw material of following parts by weight
Part, 3~8 parts of butanediol, biological -1 2~6 part of carbohydrate gum, hamamelis flower 2~6 parts of water, 1~3 part of ammonia sugar, purple perilla
1~3 part of (PERILLA OCYMOIDES) leaf extract, bacterium found 0.5~2 part of peptide, arginine/0.5~2 part of lysine polypeptide, resist
0.5~2 part of acne peptide, 0.1~1.5 part of folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1) 0.1~0.5
Part, 0.2~0.5 part of parahydroxyacet-ophenone, 0.05~0.2 part of Sodium Hyaluronate, 0.05~0.2 part of dipotassium glycyrrhizinate, allantoin
0.05~0.2 part, 0.03~0.8 part of xanthan gum, 0.03~0.08 part of EDETATE SODIUM.
Most preferably, the parts by weight of the adding raw materials are respectively as follows: 80.9 parts of water, 5 parts of butanediol, biological carbohydrate gum -1 3
Part, hamamelis flower 3 parts of water, peace sugar 2 parts, 1.5 parts of purple perilla (PERILLA OCYMOIDES) leaf extract, bacterium stand 1 part of peptide,
Arginine/1 part of lysine polypeptide, 1 part of anti-acne peptide, 0.5 part of folic acid, 0.4 part of A91,0.3 part of parahydroxyacet-ophenone, hyaluronic acid
0.1 part of sodium, 0.1 part of dipotassium glycyrrhizinate, 0.1 part of allantoin, 0.05 part of xanthan gum, 0.05 part of EDETATE SODIUM.
The present invention also provides a kind of antibacterial essences of polypeptide compound acne-removing to use the manner of packing that high activity saves, institute
Yeast beauty treatment essence is stated to be accommodated in ampulla.Ampulla good seal performance, disposable, the hard glass for that can seal holds
Device is usually used in storing drug and vaccine, serum of injection etc., and hermetically sealed encapsulation can better ensure that the activity of yeast,
Avoiding reduces the activity of its yeast because long-time is placed.
Preferably, it also limits ampulla material and shape is defined, the ampulla silicon content is 7.0%~12.0%.
The upper half of the ampulla fracture and lower half ratio are 0.5:1~1:1.The ampulla break disconnected power size be 40N~
60N。
The present invention also provides a kind of preparation methods of antibacterial essence of polypeptide compound acne-removing comprising following steps:
S1: butanediol, xanthan gum, allantoin, Sodium Hyaluronate being added into the container after disinfection, are dispersed with stirring completely
Later, it is heated to 70 DEG C~80 DEG C while stirring, makes it dissolve completely；Water, EDETATE SODIUM, parahydroxyacet-ophenone, heating is added
To 80 DEG C~85 DEG C, mixing speed is opened to 20~30RPM, and 5~10min is sufficiently stirred, and forms mixed liquor；
S2: the mixed liquor in S1 being continued to be heated to 85 DEG C~95 DEG C, and improve the mixing speed of emulsion pot to 30~
40RPM makes it that dissolution be sufficiently stirred, and keeps the temperature 30~60min；
S3: by the mixed liquor in S2, after being cooled to 35 DEG C~45 DEG C using stirring, biological carbohydrate gum -1, North America gold thread is added
Plum blossom water, peace sugar, purple perilla (PERILLA OCYMOIDES) leaf extract, the vertical peptide of bacterium, arginine/lysine polypeptide, anti-acne peptide,
Folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1), dipotassium glycyrrhizinate are cooled to 20 after mixing evenly
DEG C~30 DEG C to get the essence；
S4: filling, packaging obtains the antibacterial essence finished product of polypeptide compound acne-removing.
Compared with existing acne-eliminating cosmetic product, the invention has the following beneficial effects: (1) to provide one kind safely and effectively
Anti-acne essence compounds polypeptide, diminishes inflammation, and reduces stimulation, promotes skin repair, naturally safely and effectively.(2) a kind of polypeptide is provided
Active high-effect preserving type.Ampulla is to apply the relatively effective mode for saving drug, effective component in medicine that can be pacified
All risk insurance is deposited, it is advantageous that, controlled atmosphere technology is used using inert gases such as nitrogen, completely cuts off the oxygen in air, reaches
Hypoxemia even oxygen-free environment, enables the effective active matter in ampulla effectively to be saved, guarantees that it still has when in use
There is high activity.(3) in raw material compounding mechanism, this product mainly founds peptide as primary efficacy object using bacterium, and mild antibiotic effectively eliminates
The basic source of small pox；It adds dipotassium glycyrrhizinate and arginine/lysine polypeptide accelerates the elimination of inflammation, accelerate disappearing for illness
It removes；To the north of the plant extracts such as U.S. dollar thread plum blossom water, perilla leaf extract be auxiliary, inhibit the same of propionibacterium acnes growth
When, the excessive secretion of skin oil and fat can be inhibited, to prevent the generation again of small pox；Matrine, folic acid, allantoin is added to increase
The self-regeneration speed of skin reduces the trace that small pox leaves.
The present invention can effectively inhibit the excessive multiplication of skin harmful bacteria, promote inflammation disappearance and skin repair, subtract simultaneously
Few skin oil and fat excessive secretion, reduces the recurrence of small pox, improves skin, skin is made to keep fit.Use ampulla as production
The packaging of product effectively saves the activity of functional component, reduces extraneous factor and plays active interference to active matter.
Specific embodiment
The technical scheme adopted by the invention is as follows: a kind of antibacterial essence of polypeptide compound acne-removing, prepared by following raw material and
At: butanediol, biological carbohydrate gum -1, hamamelis flower water, ammonia sugar, purple perilla (PERILLA OCYMOIDES) leaf extract, bacterium are vertical
It is peptide, arginine/lysine polypeptide, anti-acne peptide, folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1), right
Hydroxy acetophenone, Sodium Hyaluronate, dipotassium glycyrrhizinate, allantoin, xanthan gum, EDETATE SODIUM and water.
The antibacterial essence of polypeptide compound acne-removing of the present invention is made by the raw material of following parts by weight: 70~85 parts of water, butanediol 1
~10 parts, biological -1 1~8 part of carbohydrate gum, hamamelis flower 1~8 part of water, 1~5 part of ammonia sugar, purple perilla (PERILLA
OCYMOIDES) 1~4 part of leaf extract, bacterium stand 0.5~4 part of peptide, arginine/0.5~3 part of lysine polypeptide, anti-acne peptide 0.5~
3 parts, 0.1~2 part of folic acid, 0.1~0.8 part of A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1), para hydroxybenzene
0.1~0.5 part of ethyl ketone, 0.05~0.3 part of Sodium Hyaluronate, 0.01~0.3 part of dipotassium glycyrrhizinate, 0.05~0.3 part of allantoin,
0.01~0.1 part of xanthan gum, 0.01~0.1 part of EDETATE SODIUM.
Preferably, the antibacterial essence of polypeptide compound acne-removing, is made: water 80~83 by the raw material of following parts by weight
Part, 3~8 parts of butanediol, biological -1 2~6 part of carbohydrate gum, hamamelis flower 2~6 parts of water, 1~3 part of ammonia sugar, purple perilla
1~3 part of (PERILLA OCYMOIDES) leaf extract, bacterium found 0.5~2 part of peptide, arginine/0.5~2 part of lysine polypeptide, resist
0.5~2 part of acne peptide, 0.1~1.5 part of folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1) 0.1~0.5
Part, 0.2~0.5 part of parahydroxyacet-ophenone, 0.05~0.2 part of Sodium Hyaluronate, 0.05~0.2 part of dipotassium glycyrrhizinate, allantoin
0.05~0.2 part, 0.03~0.8 part of xanthan gum, 0.03~0.08 part of EDETATE SODIUM.
Most preferably, the parts by weight of the adding raw materials are respectively as follows: 80.9 parts of water, 5 parts of butanediol, biological carbohydrate gum -1 3
Part, hamamelis flower 3 parts of water, peace sugar 2 parts, 1.5 parts of purple perilla (PERILLA OCYMOIDES) leaf extract, bacterium stand 1 part of peptide,
Arginine/1 part of lysine polypeptide, 1 part of anti-acne peptide, 0.5 part of folic acid, 0.4 part of A91,0.3 part of parahydroxyacet-ophenone, hyaluronic acid
0.1 part of sodium, 0.1 part of dipotassium glycyrrhizinate, 0.1 part of allantoin, 0.05 part of xanthan gum, 0.05 part of EDETATE SODIUM.
In order to improve the high activity of the antibacterial essence of polypeptide compound acne-removing of the present invention, the yeast beauty treatment essence is accommodated in
In ampulla.Ampulla good seal performance, it is disposable, for the hard glass container that can be sealed, it is usually used in storing injection
Drug and vaccine, serum etc., hermetically sealed encapsulation can better ensure that the activity of yeast, avoid due to long-time is placed
Reduce the activity of its yeast.
For the present invention by a large amount of experiment discovery, the bacterium being added, which founds the polypeptides such as peptide compounding, can effectively reduce the generation of small pox
Probability diminishes inflammation, and improves skin oil and fat and secretes situation.The present invention provides a kind of plant and the antibacterial essence of polypeptide compound acne-removing is pacified
Bottle research and development and preparation method, found anti-acne essence ampulla of the peptide as primary efficacy object using bacterium, can effectively inhibit skin acne propionic acid bar
The excessive multiplication of bacterium, promotes the disappearance and skin self-healing of inflammation, while cooperating hamamelis flower water, purple perilla (PERILLA
OCYMOIDES) a variety of natural plant extracts components such as leaf extract reduce the recurrence of grease excessive secretion and small pox, improve
Skin makes skin keep fit.Ingredient origin used is natural, safe, non-stimulated, part material Action Specification in the present invention
It is as follows:
(1) hamamelis flower water.Have the function of calmness of releiving, keep metabolic balance, control fat secretion, restrains,
Keep metabolic balance.Also have effects that certain antibiotic effect simultaneously and reduces ultraviolet injury.
(2) purple perilla (PERILLA OCYMOIDES) leaf extract.Permeability is strong, has certain oxidation resistance, antibacterial
And anti-allergic effects, there are also the effects of preservation antioxidation, can effectively inhibit the breeding of gold-coloured staphylococci and Escherichia coli.
(3) bacterium founds peptide (water: propylene glycol: lactobacillus-fermented product=2:1:1).Lactobacillus-fermented product streptococcus lactis peptide has light
Biocidal property is composed, has high inhibition effect to Gram-negative bacteria and positive bacteria, can effectively inhibit propionibacterium acnes, reduces acne
Generation, eliminate small pox.
(4) anti-acne peptide promotes the resistance of skin, reduces sebum secretion and increases skin moisturizing degree.Anti-acne peptide passes through induction
Skin natural defending system is strengthened in the expression of endogenous alexin (people's beta-alexin -2 and -3), protects the skin from extraneous micro-
The infringement of biology, while reducing infection risk.Suitable for various oil-controls and product for resolving poxes
(5) micromolecule polypeptide that arginine/lysine polypeptide conotoxin peptide is made of 10~30 amino acid residues, greatly
It is rich in cysteine more, there is highly conserved disulfide bond skeleton, be allowed to form the three-dimensional conformation of High definition.According to structure sequence
Column and target site, μ-CTX conotoxin peptide belong to μ-family of M- superfamily, are Na+ channel blockers, and it is logical to act on sodium ion
Road Nav1.4 hypotype can allow striated muscle, loosening all muscles to get off and play by the nerve signal transmitting between block nerves and muscle
Excellent anti-wrinkle effect.
(6) allantoin.It is mainly used for skin condition, protective action has sterilization, anti-inflammatory, analgesic, antioxidation, promotees
Into cell repair.
(7) Sodium Hyaluronate.Ability with extremely strong absorption and holding moisture, keeps skin water profit, increases gloss, put down
Sliding skin.
(8) biological carbohydrate gum -1.Containing multiple sulfates, energy polymeric anion compound, powerful hydratability has good
Good moisture retention, wetability also can carry out a degree of reparation to damaged skin.
(9) N- acetylglucosamine.The basic composition unit of many important polysaccharide in biological cell, be synthesis bifid because
The important prerequisite of son has many important physiological functions in vivo, can reach moisturizing and moisturizing for human skin
Effect, and refinement dermatoglyph, enhancing elasticity.
(10) dipotassium glycyrrhizinate.The mainly Radix Glycyrrhizae sour component of Radix Glycyrrhizae root and stem has anti-thorn to anaphylaxis skin
Swash, moves back red detumescence Healing.Effectively prevent stimulated the phenomenon that the leading to sensitive inflammation generation of skin, inflammation caused by counterglow
Has the function of anti-inflammatory calmness.
Embodiment one
A kind of antibacterial essence of polypeptide compound acne-removing, is followed these steps to be prepared by following raw material:
(1) 5 parts of butanediol, 0.05 part of xanthan gum, 0.1 part of allantoin, hyaluronic acid are added into the container after disinfection
0.1 part of sodium, after being dispersed with stirring completely, it is heated to 70 DEG C~80 DEG C while stirring, makes it dissolve completely；80.9 parts of water of addition,
0.05 part of EDETATE SODIUM, 0.3 part of parahydroxyacet-ophenone, are heated to 80 DEG C~85 DEG C, and mixing speed is opened to 20~30RPM, sufficiently
5~10min is stirred, mixed liquor is formed；
(2) mixed liquor in (1) is continued to be heated to 85 DEG C~95 DEG C, and improve the mixing speed of emulsion pot to 30~
40RPM makes it that dissolution be sufficiently stirred, and keeps the temperature 30~60min；
(3) after the mixed liquor in S2 being cooled to 35 DEG C~45 DEG C using stirring, biological -1 3 part of carbohydrate gum, North America gold is added
3 parts of thread plum blossom water, 2 parts of peace sugar, 1.5 parts of purple perilla (PERILLA OCYMOIDES) leaf extract, vertical 1 part of the peptide of bacterium, arginine/rely
1 part of propylhomoserin polypeptide, 1 part of anti-acne peptide, 0.5 part of folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1) 0.4
Part, 0.1 part of dipotassium glycyrrhizinate, after mixing evenly, are cooled to 20 DEG C~30 DEG C to get the essence；
(4) filling, packaging is transferred in ampulla, prepares the antibacterial essence finished product of polypeptide compound acne-removing.
Embodiment two
A kind of antibacterial essence of polypeptide compound acne-removing, is followed these steps to be prepared by following raw material:
(1) 5 parts of butanediol, 0.05 part of xanthan gum, 0.1 part of allantoin, hyaluronic acid are added into the container after disinfection
0.1 part of sodium, after being dispersed with stirring completely, it is heated to 70 DEG C~80 DEG C while stirring, makes it dissolve completely；81.4 parts of water of addition,
0.05 part of EDETATE SODIUM, 0.3 part of parahydroxyacet-ophenone, are heated to 80 DEG C~85 DEG C, and mixing speed is opened to 20~30RPM, sufficiently
5~10min is stirred, mixed liquor is formed；
(2) mixed liquor in (1) is continued to be heated to 85 DEG C~95 DEG C, and improve the mixing speed of emulsion pot to 30~
40RPM makes it that dissolution be sufficiently stirred, and keeps the temperature 30~60min；
(3) after the mixed liquor in S2 being cooled to 35 DEG C~45 DEG C using stirring, biological -1 3 part of carbohydrate gum, North America gold is added
3 parts of thread plum blossom water, 2 parts of peace sugar, 1.5 parts of purple perilla (PERILLA OCYMOIDES) leaf extract, vertical 0.5 part of the peptide of bacterium, arginine/
1 part of lysine polypeptide, 1 part of anti-acne peptide, 0.5 part of folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1) 0.4
Part, 0.1 part of dipotassium glycyrrhizinate, after mixing evenly, are cooled to 20 DEG C~30 DEG C to get the essence；
(4) filling, packaging is transferred in ampulla, prepares the antibacterial essence finished product of polypeptide compound acne-removing.
Embodiment three
A kind of antibacterial essence of polypeptide compound acne-removing, is followed these steps to be prepared by following raw material:
(1) 5 parts of butanediol, 0.05 part of xanthan gum, 0.1 part of allantoin, hyaluronic acid are added into the container after disinfection
0.1 part of sodium, after being dispersed with stirring completely, it is heated to 70 DEG C~80 DEG C while stirring, makes it dissolve completely；80.4 parts of water of addition,
0.05 part of EDETATE SODIUM, 0.3 part of parahydroxyacet-ophenone, are heated to 80 DEG C~85 DEG C, and mixing speed is opened to 20~30RPM, sufficiently
5~10min is stirred, mixed liquor is formed；
(2) mixed liquor in (1) is continued to be heated to 85 DEG C~95 DEG C, and improve the mixing speed of emulsion pot to 30~
40RPM makes it that dissolution be sufficiently stirred, and keeps the temperature 30~60min；
(3) after the mixed liquor in S2 being cooled to 35 DEG C~45 DEG C using stirring, biological -1 3 part of carbohydrate gum, North America gold is added
3 parts of thread plum blossom water, 2 parts of peace sugar, 1.5 parts of purple perilla (PERILLA OCYMOIDES) leaf extract, vertical 1.5 parts of the peptide of bacterium, arginine/
1 part of lysine polypeptide, 1 part of anti-acne peptide, 0.5 part of folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1) 0.4
Part, 0.1 part of dipotassium glycyrrhizinate, after mixing evenly, are cooled to 20 DEG C~30 DEG C to get the essence；
(4) filling, packaging is transferred in ampulla, prepares the antibacterial essence finished product of polypeptide compound acne-removing.
Example IV
A kind of antibacterial essence of polypeptide compound acne-removing, is followed these steps to be prepared by following raw material:
(1) 5 parts of butanediol, 0.05 part of xanthan gum, 0.1 part of allantoin, hyaluronic acid are added into the container after disinfection
0.1 part of sodium, after being dispersed with stirring completely, it is heated to 70 DEG C~80 DEG C while stirring, makes it dissolve completely；80.4 parts of water of addition,
0.05 part of EDETATE SODIUM, 0.3 part of parahydroxyacet-ophenone, are heated to 80 DEG C~85 DEG C, and mixing speed is opened to 20~30RPM, sufficiently
5~10min is stirred, mixed liquor is formed；
(2) mixed liquor in (1) is continued to be heated to 85 DEG C~95 DEG C, and improve the mixing speed of emulsion pot to 30~
40RPM makes it that dissolution be sufficiently stirred, and keeps the temperature 30~60min；
(3) after the mixed liquor in S2 being cooled to 35 DEG C~45 DEG C using stirring, biological -1 3 part of carbohydrate gum, North America gold is added
3 parts of thread plum blossom water, 2 parts of peace sugar, 2 parts of purple perilla (PERILLA OCYMOIDES) leaf extract, bacterium found 1 part of peptide, arginine/bad ammonia
1 part of sour polypeptide, 1 part of anti-acne peptide, 0.5 part of folic acid, 0.4 part of A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1),
0.1 part of dipotassium glycyrrhizinate, after mixing evenly, 20 DEG C~30 DEG C are cooled to get the essence；
(4) filling, packaging is transferred in ampulla, prepares the antibacterial essence finished product of polypeptide compound acne-removing.
Embodiment five
A kind of antibacterial essence of polypeptide compound acne-removing, is followed these steps to be prepared by following raw material:
(1) 5 parts of butanediol, 0.05 part of xanthan gum, 0.1 part of allantoin, hyaluronic acid are added into the container after disinfection
0.1 part of sodium, after being dispersed with stirring completely, it is heated to 70 DEG C~80 DEG C while stirring, makes it dissolve completely；81.4 parts of water of addition,
0.05 part of EDETATE SODIUM, 0.3 part of parahydroxyacet-ophenone, are heated to 80 DEG C~85 DEG C, and mixing speed is opened to 20~30RPM, sufficiently
5~10min is stirred, mixed liquor is formed；
(2) mixed liquor in (1) is continued to be heated to 85 DEG C~95 DEG C, and improve the mixing speed of emulsion pot to 30~
40RPM makes it that dissolution be sufficiently stirred, and keeps the temperature 30~60min；
(3) after the mixed liquor in S2 being cooled to 35 DEG C~45 DEG C using stirring, biological -1 3 part of carbohydrate gum, North America gold is added
3 parts of thread plum blossom water, 2 parts of peace sugar, 2 parts of purple perilla (PERILLA OCYMOIDES) leaf extract, bacterium found 1 part of peptide, arginine/bad ammonia
0.5 part of sour polypeptide, 0.5 part of anti-acne peptide, 0.5 part of folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1) 0.4
Part, 0.1 part of dipotassium glycyrrhizinate, after mixing evenly, are cooled to 20 DEG C~30 DEG C to get the essence；
(4) filling, packaging is transferred in ampulla, prepares the antibacterial essence finished product of polypeptide compound acne-removing.
Reference examples 1
A kind of plant and the antibacterial essence ampulla research and development of polypeptide compound acne-removing and preparation, press following step by following raw material
Suddenly it is prepared:
(1) 5 parts of butanediol, 0.05 part of xanthan gum, 0.1 part of allantoin, hyaluronic acid are added into the container after disinfection
0.1 part of sodium, after being dispersed with stirring completely, it is heated to 70 DEG C~80 DEG C while stirring, makes it dissolve completely；85.4 parts of water of addition,
0.05 part of EDETATE SODIUM, 0.3 part of parahydroxyacet-ophenone, are heated to 80 DEG C~85 DEG C, and mixing speed is opened to 20~30RPM, sufficiently
5~10min is stirred, mixed liquor is formed；
(2) mixed liquor in (1) is continued to be heated to 85 DEG C~95 DEG C, and improve the mixing speed of emulsion pot to 30~
40RPM makes it that dissolution be sufficiently stirred, and keeps the temperature 30~60min；
(3) after the mixed liquor in S2 being cooled to 35 DEG C~45 DEG C using stirring, biological -1 3 part of carbohydrate gum, North America gold is added
3 parts of thread plum blossom water, peace sugar 2 parts, 0.5 part of folic acid, 0.4 part of A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1),
0.1 part of dipotassium glycyrrhizinate, after mixing evenly, 20 DEG C~30 DEG C are cooled to get the essence；
(4) filling, packaging.
Effect assessment
1, the male and female number of suitable different age group totally 50 people is chosen, is divided into 5 groups, every group of 10 people use 5 respectively
Money embodiment product and 1 section of reference examples product, left half of face continuous use embodiment, right half of face continuous use reference examples
Product illustrates effect from the following aspect respectively, and does blank control；
2, using VISIA skin image analyzer, observation was changed using 11 days rear face skin redness areas.Red color area represents
Potential various symptoms, such as acne, inflammation, brandy nose or spider vein.The blood contained in papillary dermis (one layer of skin)
It is red that these structures are presented in pipe and hemoglobin, this can be detected by the RBX technology in VISIA skin image analyzer.
Acne spot and inflammation it is of different sizes but usually circular.
Compared with acne, brandy nose is usually larger and diffuse, and spider vein is usually short and thin and can be intensive
It is interconnected in network.Product using effect is indicated using score value, score value can measure influence of the function to client's face comprehensively.
Intensity of the score value factor in the analyzed example of total size and area and detected feature.When the size of Example characteristics and strong
Degree is when treating the most index of correlation of validity, and score value can be used for tracking therapeutic advance.Score value increase shows that in vain, value added is
Negative and increment shows that effectively value added is negative and increment is greater than 5 and shows significantly effectively no more than 5.Effect situation is shown in Table 1.
Table 1 uses 11 days rear face red color area variation effect situations of product
| Effect | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Reference examples 1 |
| (%) in vain | 10 | 20 | 10 | 10 | 20 | 85 |
| Effectively (%) | 20 | 20 | 40 | 60 | 50 | 10 |
| Significant effective (%) | 70 | 60 | 50 | 30 | 30 | 5 |
3, using Skin-SP skinanalysis apparatus, skin of face surface grease changes when observing the 11st day.With grease score table
Show using effect, score value is higher, and expression cutaneous manifestations are more oily, and score value increase shows in vain, and value added is negative and no more than 5 points
Show effectively, negative value added is greater than 5 points and shows significantly effectively.Effect situation is shown in Table 2.
Table 2 uses 11 days rear face grease situations of change of product
| Effect | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Reference examples 1 |
| (%) in vain | 10 | 10 | 10 | 20 | 10 | 80 |
| Effectively (%) | 30 | 50 | 60 | 60 | 60 | 15 |
| Significant effective (%) | 60 | 40 | 30 | 20 | 30 | 5 |
By being detected using the antibacterial essence of polypeptide compound acne-removing of the present invention in facial red area referring to test comparison
It is seen in facial oil variation comparison, essence of the present invention is in effectively control acne, inflammation, brandy nose or spider vein and oil
On the problems such as rouge is secreted, by good experiment clinical data, the effect for having significant is illustrated.
Claims (8)
1. a kind of antibacterial essence of polypeptide compound acne-removing, which is characterized in that be made by the raw material of following parts by weight: water 70~85
Part, 1~10 part of butanediol, biological -1 1~8 part of carbohydrate gum, hamamelis flower 1~8 part of water, 1~5 part of ammonia sugar, purple perilla
1~4 part of (PERILLA OCYMOIDES) leaf extract, bacterium found 0.5~4 part of peptide, arginine/0.5~3 part of lysine polypeptide, resist
0.5~3 part of acne peptide, 0.1~2 part of folic acid, 0.1~0.8 part of A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1),
0.1~0.5 part of parahydroxyacet-ophenone, 0.05~0.3 part of Sodium Hyaluronate, 0.01~0.3 part of dipotassium glycyrrhizinate, allantoin 0.05
~0.3 part, 0.01~0.1 part of xanthan gum, 0.01~0.1 part of EDETATE SODIUM.
2. a kind of antibacterial essence of polypeptide compound acne-removing according to claim 1, which is characterized in that by following parts by weight
Raw material is made: 80~83 parts of water, 3~8 parts of butanediol, biological -1 2~6 part of carbohydrate gum, hamamelis flower 2~6 parts of water, ammonia sugar 1
~3 parts, 1~3 part of purple perilla (PERILLA OCYMOIDES) leaf extract, bacterium vertical 0.5~2 part of peptide, arginine/lysine polypeptide
0.5~2 part, 0.5~2 part of anti-acne peptide, 0.1~1.5 part of folic acid, A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:
1) 0.1~0.5 part, 0.2~0.5 part of parahydroxyacet-ophenone, 0.05~0.2 part of Sodium Hyaluronate, dipotassium glycyrrhizinate 0.05~0.2
Part, 0.05~0.2 part of allantoin, 0.03~0.8 part of xanthan gum, 0.03~0.08 part of EDETATE SODIUM.
3. a kind of antibacterial essence of polypeptide compound acne-removing according to claim 2, which is characterized in that by following parts by weight
Raw material is made: 80.9 parts of water, 5 parts of butanediol, biological -1 3 part of carbohydrate gum, 3 parts of water of hamamelis flower, ammonia sugared 2 parts, purple perilla
1.5 parts of (PERILLA OCYMOIDES) leaf extract, bacterium found 1 part of peptide, arginine/1 part of lysine polypeptide, 1 part of anti-acne peptide, leaf
It is 0.5 part of acid, 0.4 part of A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1), 0.3 part of parahydroxyacet-ophenone, transparent
0.1 part of matter acid sodium, 0.1 part of dipotassium glycyrrhizinate, 0.1 part of allantoin, 0.05 part of xanthan gum, 0.05 part of EDETATE SODIUM.
4. the antibacterial essence of polypeptide compound acne-removing according to claim 1, which is characterized in that the polypeptide compound acne-removing suppression
Bacterium essence is accommodated in ampulla.
5. the formula of yeast beauty treatment essence according to claim 4, which is characterized in that the ampulla silicon content is
7.0%~12.0%.
6. the formula of yeast beauty treatment essence according to claim 4, which is characterized in that the upper half of the ampulla fracture
Portion and lower half ratio are 0.5:1~1:1.
7. the formula of yeast beauty treatment essence according to claim 4, which is characterized in that the ampulla breaks disconnected power size
For 40N~60N.
8. a kind of preparation method of the antibacterial essence of polypeptide compound acne-removing, characterized by the following steps:
S1: into the container after disinfection be added butanediol, xanthan gum, allantoin, Sodium Hyaluronate, be dispersed with stirring it is complete it
Afterwards, it is heated to 70 DEG C~80 DEG C while stirring, makes it dissolve completely；Water, EDETATE SODIUM, parahydroxyacet-ophenone is added, is heated to
80 DEG C~85 DEG C, mixing speed is opened to 20~30RPM, and 5~10min is sufficiently stirred, and forms mixed liquor；
S2: the mixed liquor in S1 being continued to be heated to 85 DEG C~95 DEG C, and improve the mixing speed of emulsion pot to 30~
40RPM makes it that dissolution be sufficiently stirred, and keeps the temperature 30~60min；
S3: by the mixed liquor in S2, after being cooled to 35 DEG C~45 DEG C using stirring, biological carbohydrate gum -1, hamamelis flower is added
Water, peace sugar, purple perilla (PERILLA OCYMOIDES) leaf extract, the vertical peptide of bacterium, arginine/lysine polypeptide, anti-acne peptide, folic acid,
A91 (decoyl hydroximic acid: propylene glycol: glycerol caprylate=1:2:1), dipotassium glycyrrhizinate are cooled to 20 DEG C~30 after mixing evenly
DEG C to get the essence；
S4: filling, packaging obtains the antibacterial essence finished product of polypeptide compound acne-removing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910805273.6A CN110339084A (en) | 2019-08-29 | 2019-08-29 | A kind of formula and preparation method thereof of the antibacterial essence of polypeptide compound acne-removing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910805273.6A CN110339084A (en) | 2019-08-29 | 2019-08-29 | A kind of formula and preparation method thereof of the antibacterial essence of polypeptide compound acne-removing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110339084A true CN110339084A (en) | 2019-10-18 |
Family
ID=68181359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910805273.6A Pending CN110339084A (en) | 2019-08-29 | 2019-08-29 | A kind of formula and preparation method thereof of the antibacterial essence of polypeptide compound acne-removing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110339084A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711163A (en) * | 2019-11-27 | 2020-01-21 | 珠海伊斯佳科技股份有限公司 | Instant firming essence and preparation method and application thereof |
| CN111686146A (en) * | 2020-06-01 | 2020-09-22 | 中国科学院合肥物质科学研究院 | Antibacterial, anti-inflammatory and antipruritic composition and preparation method thereof |
| CN112957293A (en) * | 2021-02-21 | 2021-06-15 | 广东贝诗特生物科技有限公司 | Acne-removing repair cream and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453081A (en) * | 2018-12-07 | 2019-03-12 | 广州天玺生物科技有限公司 | A kind of preparation method of plant and the antibacterial essence of polypeptide compound acne-removing |
| CN109464333A (en) * | 2018-12-07 | 2019-03-15 | 广州天玺生物科技有限公司 | A kind of preparation method of compound plant whitening yellow fading essence |
-
2019
- 2019-08-29 CN CN201910805273.6A patent/CN110339084A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453081A (en) * | 2018-12-07 | 2019-03-12 | 广州天玺生物科技有限公司 | A kind of preparation method of plant and the antibacterial essence of polypeptide compound acne-removing |
| CN109464333A (en) * | 2018-12-07 | 2019-03-15 | 广州天玺生物科技有限公司 | A kind of preparation method of compound plant whitening yellow fading essence |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711163A (en) * | 2019-11-27 | 2020-01-21 | 珠海伊斯佳科技股份有限公司 | Instant firming essence and preparation method and application thereof |
| CN111686146A (en) * | 2020-06-01 | 2020-09-22 | 中国科学院合肥物质科学研究院 | Antibacterial, anti-inflammatory and antipruritic composition and preparation method thereof |
| CN112957293A (en) * | 2021-02-21 | 2021-06-15 | 广东贝诗特生物科技有限公司 | Acne-removing repair cream and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109157450B (en) | Acne-removing essence | |
| KR101183075B1 (en) | Porifera-based therapeutic compositions for treating and preventing skin diseases | |
| EP3708152B1 (en) | Azelaic acid gel, and preparation method and application thereof | |
| CN110585114B (en) | Bactericidal composition for regulating skin microbial flora and application thereof | |
| KR20180033179A (en) | Petrolatum-system delivery system for active ingredients | |
| CN110339084A (en) | A kind of formula and preparation method thereof of the antibacterial essence of polypeptide compound acne-removing | |
| Han et al. | Subdermal minimal surgery with hyaluronic acid as an effective treatment for neck wrinkles | |
| CN109125107B (en) | Polypeptide composition for effectively improving and repairing facial hormone-dependent dermatitis | |
| CN109260075B (en) | Acne-removing conditioning water | |
| CN110882207A (en) | Preparation process and method of essence for skin repair | |
| CN112402347A (en) | Acne-removing repair composition containing fibronectin and preparation method thereof | |
| CN110721117A (en) | Freeze-dried powder preparation of beauty and skin care cosmetics and application of freeze-dried powder preparation in solution | |
| CN106389139A (en) | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof | |
| CN107670027B (en) | Compositions and methods for treating skin conditions | |
| JP2021527134A (en) | Composition for the treatment of skin conditions | |
| CN109453081A (en) | A kind of preparation method of plant and the antibacterial essence of polypeptide compound acne-removing | |
| CN113384482A (en) | Moisturizing and skin-tendering essence and preparation method thereof | |
| CN115429738B (en) | Acne-removing, repairing and reviving essence and preparation method thereof | |
| US9375462B1 (en) | Composition for healing skin | |
| CN108078868B (en) | Antiallergic composition for skin care products | |
| CN107028830B (en) | Medicine for preventing scar hyperplasia and preparation process thereof | |
| US9867874B1 (en) | Composition for regulating immunomodulation of skin | |
| CN106511153B (en) | Nanometer composition with acne removing effect and cosmetic or skin care product thereof | |
| He et al. | Sodium hyaluronates applied in the face affects the diversity of skin microbiota in healthy people | |
| CN107595723B (en) | Composition with acne removing, whitening and moisturizing effects and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191018 |
|
| RJ01 | Rejection of invention patent application after publication |