CN110339082A - A kind of composition and its preparation method and application with skin-care effect - Google Patents
A kind of composition and its preparation method and application with skin-care effect Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The present invention relates to nano biological beauty product technical fields, more particularly to a kind of composition and its preparation method and application with skin-care effect, the composition includes the raw material of following parts by weight: 20~50 parts of 5~25 parts of recombinant human epidermal growth factor, 20~100 parts of nano grade amino acid, 15~50 parts of nanoscale Co-Q10,20~50 parts of the medical vitamin C of nanoscale, 20~50 parts of the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale.Composition of the invention is reduced costs by using recombinant human epidermal growth factor, and uses nano raw material, can freely penetrate into Skin Cell, effective component can allow skin to fully absorb；It can also promote epidermal cell metabolism, repair damaged cell, moisturize the skin, enhance skin elasticity, reduce wrinkle of skin and prevent skin aging.
Description
Technical field
The present invention relates to nano biological beauty product technical fields, and in particular to a kind of composition with skin-care effect and
Preparation method and application.
Background technique
In recent years, beauty market emerges a large amount of facial treatment essence liquid.But the effective component of existing Essence be mostly plant at
Point extract, and liquid itself belongs to fine chemical product, and in order to improve the beautification function of cosmetics, majority containing lead,
Mercury, alcohol, preservative, hormone, fragrance etc. are to the harmful substance of skin.Consumer using Essence maintenance skin while,
Also the problems such as causing very major injury to skin, or even generating color spot, red capillary, allergy, causes consumer's health
Greatly threaten.In addition, existing product mostly passes through the refinement of chemical industry method and is made, harmful organic substance in product residual compared with
More, long-time service can have an adverse effect to skin.Moreover, most existing products lack animality active material, can not promote
Into the metabolism of epidermal cell, improve skin quality.
Application No. is 201310345593.0 Chinese invention patent disclose it is a kind of for cosmetology at fiber finer
Cytosol, main component are that fibroblast liquid contains cell culture fluid, collagen, Porcine HGF, amino acid and dimension
Raw element, wherein Porcine HGF include fibroblast growth factor, epithelical cell growth factor, hepatocyte growth factor and
Keratinocyte growth factor；The method for preparing fibroblast liquid includes obtaining umbilical cord tissue dermal cell, originally culture umbilical cord
Dermal tissue cell, secondary culture umbilical cord tissue dermal cell, collection cell culture fluid, addition glycerol and cell factor are made into
Fiber finer cytosol and etc..Although the fibroblast liquid has the function of promoting epidermal cell metabolism, cosmetology
It acts on limited.And the preparation method is easy easily, and culture solution processing step is few, and the probability of microbial contamination is larger, it is therefore desirable to
Its manufacture craft is improved.
Cell culture Essence is the field of biotechnology derived product that recent years, new development was got up, and utilizes culture solution
In biotic component biologically active beauty essence is made, has with classical skin-protection product glycerol, sodium hyaluronate compatibility
Significant skin effect.And the production method of the product, departing from chemical production technology, unharmful substance residual has very high
Safety, have preferable promotion and application prospect.
Application No. is the Chinese invention patent of 201410074483.X disclose a kind of Essence for cosmetology and
Preparation method, the Essence are made of cultured epidermal cell liquid, contain various kinds of cell growth factor, amino acid and vitamin.
It mainly include epithelical cell growth factor, fibroblast growth factor, Type I collagen albumen, stem cell factor, cutin is thin
The intracellular growth factor, amino acid and vitamin include γ-aminobutyric acid, ubiquinone, medical vitamin C, and medical vitamin B5 is medical
Vitamin E.Prepare the Essence method include obtain neonatal umbilical cord tissue epidermis, cell culture, collect cell culture fluid,
Filtration sterilization, concentration volume, addition active constituent, addition glycerol and sodium hyaluronate and etc..Although the beauty essence can promote
Into epidermal cell metabolism, damaged cell is repaired, and there is moistening effect, but uses various kinds of cell growth factor, price
Valuableness, and effective component is difficult to be fully absorbed by skin.
Summary of the invention
In order to overcome shortcoming and defect existing in the prior art, the purpose of the present invention is to provide one kind to have skin care function
The composition of effect, the composition are reduced costs by using recombinant human epidermal growth factor, and use nano raw material, can be certainly
By infiltration Skin Cell, effective component can allow skin to fully absorb；It can also promote epidermal cell metabolism, repair impaired
Cell moisturizes the skin, and enhances skin elasticity, reduces wrinkle of skin and prevents skin aging.
It is another object of the present invention to provide a kind of preparation method of composition with skin-care effect, the preparation sides
Method step is simple, convenient operation and control, and quality is stablized, and high production efficiency, production cost is low, can large-scale industrial production.
Another purpose of the invention is that a kind of application of composition with skin-care effect is provided, by the composition system
Standby cosmetics or skin care item can make skin become tender consolidation, wrinkle and can also be improved easily with coarse pore,
Dry and anaphylaxis skin can also get well natural state；There is good maintenance effect for coarse, dry, microgroove, and
And very clear good absorption, it can be also used in mixed way with bottom adornment, improve skin quality；For desalination scar, dark sore print, spot and contracting
It is of miraculous efficacy in terms of small pore；It is mild non-stimulated, side effect is not generated, and splendid to the skin care effect of dry skin, had
There are good market prospects.
The purpose of the invention is achieved by the following technical solution: a kind of composition with skin-care effect, the composition
Raw material including following parts by weight: 5~25 parts of recombinant human epidermal growth factor, 20~100 parts of nano grade amino acid, nanoscale are auxiliary
20~50 parts of the medical vitamin C of 15~50 parts of enzyme Q10, nanoscale, 20~50 parts of the medical vitamin B5 of nanoscale and nanoscale
20~50 parts of medical vitamin E.
The more skins of small molecule that hEGF (hEGF) is made of 53 amino acid, molecular weight are about 6000 dongles
?.HEGF is a kind of multi-functional Porcine HGF, by playing physiological action in conjunction with the hEGF receptor on cell membrane；hEGF
And the combination of cell receptor has the sensibility of height, only needs the hEGF of denier that can promote cell that above-mentioned Physiology and biochemistry occurs
Reaction.
Recombinant human epidermal growth factor (rhEGF) can stimulate epithelial cell and endothelial cell growth, make new epidermal cell
Constantly grow up to, dead skin layer is pushed and gradually fall off, keeps skin delicacy smooth.Promote the new old generation of the various cells of skin simultaneously
It thanks, enhancing cell absorbs nutriment.Promote collagen and collagen enzymatic synthesis, secretion Collagen material, hyaluronic acid and glycoprotein are adjusted
Collagenous fibres are saved, is had and is moisturized the skin, enhances skin elasticity, wrinkle of skin is reduced and prevent the effect of skin aging.
Co-Q10 has the function of anti-lipid peroxidation, and effect is more significant than vitamin E, vitamin B2, can press down
The integrality of biofilm structure is protected in the peroxidating of mitochondria processed, there is special humidification to immunity, is had and is improved phagocytosis
The phagocytic rate of cell, the generation for increasing antibody, improvement cell viability, removing free radical, raising immunity of organisms, anti-aging etc.
Effect.
Vitamin C promotes the synthesis of collagen, if collagen lacks, will lead to cell asynthesis.Vitamin
B5 Stratum Corneum has moisture-keeping function, improves skin roughness, exfoliating skin, restores skin elasticity.Vitamin E can effectively antagonize
Free radical inhibits lipid peroxide to generate, eliminate chloasma；The activity for inhibiting tyrosinase, to reduce melanin production.
Composition of the invention replaces the epidermal growth factor of higher cost, drop by using recombinant human epidermal growth factor
Low cost, and use nano grade amino acid, nanoscale Co-Q10, the medical vitamin C of nanoscale, the medical vitamin of nanoscale
The nano raw materials such as B5 and the medical vitamin E of nanoscale, can freely penetrate into Skin Cell, and effective component can allow skin sufficiently to inhale
It receives；It can also promote epidermal cell metabolism, repair damaged cell, moisturize the skin, enhance skin elasticity, reduce wrinkle of skin
With prevent skin aging.
Preferably, the composition includes the raw material of following parts by weight: recombinant human epidermal growth factor 10~20 part, nanometer
40~80 parts of grade amino acid, 25~40 parts of nanoscale Co-Q10,30~40 parts of the medical vitamin C of nanoscale, nanoscale are medical
30~40 parts of 30~40 parts of vitamin B5 and the medical vitamin E of nanoscale.
More preferably, the composition includes the raw material of following parts by weight: recombinant human epidermal growth factor 10 part, nanometer
40 parts of grade amino acid, 25 parts of nanoscale Co-Q10,30 parts of the medical vitamin C of nanoscale, the medical vitamin B5 30 of nanoscale
30 parts of part and the medical vitamin E of nanoscale.
Another preferred, the composition includes the raw material of following parts by weight: recombinant human epidermal growth factor 15 part, nanometer
60 parts of grade amino acid, 30 parts of nanoscale Co-Q10,35 parts of the medical vitamin C of nanoscale, the medical vitamin B5 35 of nanoscale
5 parts of part and the medical vitamin E of nanoscale.
Another preferred, the composition includes the raw material of following parts by weight: recombinant human epidermal growth factor 20 part, nanometer
80 parts of grade amino acid, 40 parts of nanoscale Co-Q10,40 parts of the medical vitamin C of nanoscale, the medical vitamin B5 40 of nanoscale
40 parts of part and the medical vitamin E of nanoscale.
Preferably, the nano grade amino acid includes nanoscale γ-aminobutyric acid.γ-aminobutyric acid is central nervous system
Critically important inhibitory neurotransmitter in system, it is a kind of naturally occurring non-protein composition amino acid, is had extremely important
Physiological function, it can promote the reactivity of brain, promote sleep, and beauty moisturizing delays brain aging function.
Preferably, the composition further includes 10~30 parts of auxiliary material, and the auxiliary material includes glycerol and sodium hyaluronate.It is more highly preferred to
, the mass ratio of the glycerol and the sodium hyaluronate is 50-150:1.Glycerol can be used as the guarantor of recombinant human epidermal growth factor
Agent is protected, also there is moisture-keeping efficacy；Sodium hyaluronate can play the role of unique protection skin, and skin moisturizing can be kept smooth, fine and smooth soft
Tender, high resilience has the function of wrinkle resistant, crease-resistant, beauty and health care and restores skin physiology function.After above-mentioned auxiliary material is added, this
The composition of invention can be used as Essence use.
Another object of the present invention is achieved through the following technical solutions: a kind of preparation of the composition with skin-care effect
Method includes the following steps:
(1) recombinant human epidermal growth factor is expressed in plant using technique for gene engineering, then utilizes chromatographic technique point
From purifying, freeze-drying preparation and reorganization hEGF；
(2) recombinant human epidermal growth factor is soluble in water, then sequentially add nano grade amino acid, nanoscale coenzyme
The medical vitamin C of Q10, nanoscale, the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale, stir evenly, and being made has
The composition of skin-care effect.Auxiliary material is stirring evenly and then adding into nano raw material, is then stirred for uniformly.
The present invention expresses recombinant human epidermal growth factor by using technique for gene engineering in plant, then utilizes chromatography
Technology isolates and purifies, preparation and reorganization hEGF is lyophilized, and yield is higher, cost is relatively low and human body itself secretion it is complete
It is complete the same, and dependence without any side effects to human body.
An also purpose of the invention is achieved through the following technical solutions: a kind of composition with skin-care effect is in beauty
The application of product or skin care item.
Preferably, the composition is used for Essence or essence.
The beneficial effects of the present invention are: composition of the invention is reduced by using recombinant human epidermal growth factor
Cost, and nano raw material is used, Skin Cell can be freely penetrated into, effective component can allow skin to fully absorb；It can also promote
Epidermal cell metabolism repairs damaged cell, moisturizes the skin, and enhances skin elasticity, reduces wrinkle of skin and prevents skin from declining
Always.
Preparation method step of the invention is simple, convenient operation and control, and quality is stablized, and high production efficiency, production cost is low,
It can large-scale industrial production.
The cosmetics or skin care item that the present invention is prepared by the composition can make skin become tender consolidation, wrinkle with it is thick
Big pore can also be improved easily, and dry and anaphylaxis skin can also get well natural state；For coarse, dry
Dry, microgroove has good maintenance effect, and very clear good absorption, can also be used in mixed way with bottom adornment, improves skin quality；It is right
It is of miraculous efficacy in terms of desalination scar, dark sore print, spot and diminution pore；It is mild non-stimulated, side effect is not generated, and right
The skin care effect of dry skin is splendid, has good market prospects.
Specific embodiment
For the ease of the understanding of those skilled in the art, below with reference to embodiment, the present invention is further illustrated, real
The content that the mode of applying refers to not is limitation of the invention.
Embodiment 1
A kind of composition with skin-care effect, the composition include the raw material of following parts by weight: recombinant human epidermal is raw
5 parts of the long factor, 20 parts of nano grade amino acid, 15 parts of nanoscale Co-Q10,20 parts of the medical vitamin C of nanoscale, nanoscale doctor
With 20 parts of 20 parts of vitamin B5 and the medical vitamin E of nanoscale.
The nano grade amino acid includes nanoscale γ-aminobutyric acid.
The composition further includes 10 parts of auxiliary material, and the auxiliary material includes glycerol and sodium hyaluronate, and the glycerol and the glass are urinated
The mass ratio of acid is 50:1.
A kind of preparation method of the composition with skin-care effect, includes the following steps:
(1) recombinant human epidermal growth factor is expressed in plant using technique for gene engineering, then utilizes chromatographic technique point
From purifying, freeze-drying preparation and reorganization hEGF；
(2) recombinant human epidermal growth factor is soluble in water, then sequentially add nano grade amino acid, nanoscale coenzyme
The medical vitamin C of Q10, nanoscale, the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale, stir evenly, and being made has
The composition of skin-care effect.
A kind of application of the composition with skin-care effect in cosmetics or skin care item.The composition for Essence or
Essence.
Clinical application example 1: Huang Nvshi, 28 years old, symptom: having dry skin, and uses the embodiment of the present invention 1 after morning and evening face cleaning respectively
Essence be applied to face, after 15 days, skin becomes moist.
Embodiment 2
The present embodiment and above-described embodiment 1 the difference is that: the composition includes the raw material of following parts by weight: weight
10 parts of hEGF of group, nano grade amino sour 40 parts, 25 parts of nanoscale Co-Q10, the medical vitamin C 30 of nanoscale
30 parts of part, 30 parts of the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale.
The composition further includes 15 parts of auxiliary material, and the auxiliary material includes glycerol and sodium hyaluronate, and the glycerol and the glass are urinated
The mass ratio of acid is 80:1.
Clinical application example 2: Li Nvshi, 42 years old, symptom: crow's feet, respectively using the embodiment of the present invention 2 after morning and evening face cleaning
Essence is applied to face, and after 15 days, crow's feet is significantly reduced.
Embodiment 3
The present embodiment and above-described embodiment 1 the difference is that: the composition includes the raw material of following parts by weight: weight
15 parts of hEGF of group, nano grade amino sour 60 parts, 30 parts of nanoscale Co-Q10, the medical vitamin C 35 of nanoscale
5 parts of part, 35 parts of the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale.
The composition further includes 20 parts of auxiliary material, and the auxiliary material includes glycerol and sodium hyaluronate, and the glycerol and the glass are urinated
The mass ratio of acid is 100:1.
Clinical application example 3: Bai Nvshi, 25 years old, symptom: augmentation rhinoplasty operative incision, it is real using the present invention respectively after morning and evening face cleaning
The Essence for applying example 3 is applied to face, and after 15 days, wound healing, the surface of a wound is flat and smooth.
Embodiment 4
The present embodiment and above-described embodiment 1 the difference is that: the composition includes the raw material of following parts by weight: weight
20 parts of hEGF of group, nano grade amino sour 80 parts, 40 parts of nanoscale Co-Q10, the medical vitamin C 40 of nanoscale
40 parts of part, 40 parts of the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale.
The composition further includes 25 parts of auxiliary material, and the auxiliary material includes glycerol and sodium hyaluronate, and the glycerol and the glass are urinated
The mass ratio of acid is 120:1.
Clinical application example 4: Jiang Nvshi, 32 years old, symptom: skin splash used the embodiment of the present invention 4 after morning and evening face cleaning respectively
Essence be applied to face, after 15 days, color spot is significantly reduced.
Embodiment 5
The present embodiment and above-described embodiment 1 the difference is that: the composition includes the raw material of following parts by weight: weight
25 parts of hEGF of group, nano grade amino sour 100 parts, 50 parts of nanoscale Co-Q10, the medical vitamin C of nanoscale
50 parts of 50 parts, 50 parts of the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale.
The composition further includes 30 parts of auxiliary material, and the auxiliary material includes glycerol and sodium hyaluronate, and the glycerol and the glass are urinated
The mass ratio of acid is 150:1.
Clinical application example 5: Chen Nvshi, 35 years old, symptom: pachylosis used the embodiment of the present invention 5 after morning and evening face cleaning respectively
Essence be applied to face, after 15 days, skin becomes tender white.
Composition of the invention is reduced costs by using recombinant human epidermal growth factor, and uses nano raw material, energy
Skin Cell is freely penetrated into, effective component can allow skin to fully absorb；Can also promote epidermal cell metabolism, repair by
Cell is damaged, is moisturized the skin, skin elasticity is enhanced, reduce wrinkle of skin and prevents skin aging.
The cosmetics or skin care item that the present invention is prepared by the composition can make skin become tender consolidation, wrinkle with it is thick
Big pore can also be improved easily, and dry and anaphylaxis skin can also get well natural state；For coarse, dry
Dry, microgroove has good maintenance effect, and very clear good absorption, can also be used in mixed way with bottom adornment, improves skin quality；It is right
It is of miraculous efficacy in terms of desalination scar, dark sore print, spot and diminution pore；It is mild non-stimulated, side effect is not generated, and right
The skin care effect of dry skin is splendid, has good market prospects.
Above-described embodiment is the preferable implementation of the present invention, and in addition to this, the present invention can be realized with other way,
Do not depart under the premise of present inventive concept it is any obviously replace it is within the scope of the present invention.
Claims (10)
1. a kind of composition with skin-care effect, it is characterised in that: the composition includes the raw material of following parts by weight: recombination
5~25 parts of hEGF, 20~100 parts of nano grade amino acid, 15~50 parts of nanoscale Co-Q10, nanoscale are medical
20~50 parts of 20~50 parts of the medical vitamin B5 of 20~50 parts of vitamin C, nanoscale and the medical vitamin E of nanoscale.
2. a kind of composition with skin-care effect according to claim 1, it is characterised in that: the composition includes such as
The raw material of lower parts by weight: 10~20 parts of recombinant human epidermal growth factor, 40~80 parts of nano grade amino acid, nanoscale Co-Q10
25~40 parts, 30~40 parts of the medical vitamin C of nanoscale, 30~40 parts of the medical vitamin B5 of nanoscale and the medical dimension of nanoscale
Raw 30~40 parts of E of element.
3. a kind of composition with skin-care effect according to claim 1, it is characterised in that: the composition includes such as
The raw material of lower parts by weight: 10 parts of recombinant human epidermal growth factor, 25 parts of nanoscale Co-Q10, is received 40 parts of nano grade amino acid
30 parts of 30 parts of the medical vitamin C of meter level, 30 parts of the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale.
4. a kind of composition with skin-care effect according to claim 1, it is characterised in that: the composition includes such as
The raw material of lower parts by weight: 15 parts of recombinant human epidermal growth factor, 30 parts of nanoscale Co-Q10, is received 60 parts of nano grade amino acid
5 parts of 35 parts of the medical vitamin C of meter level, 35 parts of the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale.
5. a kind of composition with skin-care effect according to claim 1, it is characterised in that: the composition includes such as
The raw material of lower parts by weight: 20 parts of recombinant human epidermal growth factor, 40 parts of nanoscale Co-Q10, is received 80 parts of nano grade amino acid
40 parts of 40 parts of the medical vitamin C of meter level, 40 parts of the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale.
6. a kind of composition with skin-care effect according to claim 1-5, it is characterised in that: the nanometer
Grade amino acid includes nanoscale γ-aminobutyric acid.
7. a kind of composition with skin-care effect according to claim 1-5, it is characterised in that: the combination
Object further includes 10~30 parts of auxiliary material, and the auxiliary material includes glycerol and sodium hyaluronate.
8. such as a kind of described in any item preparation methods of the composition with skin-care effect of claim 1-7, it is characterised in that:
Include the following steps:
(1) recombinant human epidermal growth factor is expressed in plant using technique for gene engineering, is then separated using chromatographic technique pure
Change, freeze-drying preparation and reorganization hEGF；
(2) recombinant human epidermal growth factor is soluble in water, it then sequentially adds nano grade amino acid, nanoscale Co-Q10, receive
The medical vitamin C of meter level, the medical vitamin B5 of nanoscale and the medical vitamin E of nanoscale, stir evenly, and being made has skin care function
The composition of effect.
9. such as a kind of described in any item compositions with skin-care effect of claim 1-7 answering in cosmetics or skin care item
With.
10. a kind of application of composition with skin-care effect according to claim 9, it is characterised in that: the combination
Object is used for Essence or essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910631615.7A CN110339082A (en) | 2019-07-12 | 2019-07-12 | A kind of composition and its preparation method and application with skin-care effect |
Applications Claiming Priority (1)
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Citations (4)
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| CN103520017A (en) * | 2013-10-22 | 2014-01-22 | 易金阳 | Wrinkle-removing, anti-ageing, skin-activating, restoring and whitening composition |
| CN103908424A (en) * | 2014-03-03 | 2014-07-09 | 奥思达干细胞有限公司 | Beautifying and nursing essence and preparation method thereof |
| CN105193676A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Acne removing composition |
| CN105596285A (en) * | 2015-11-19 | 2016-05-25 | 刘颖 | Wrinkle-eliminating nutrient solution |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520017A (en) * | 2013-10-22 | 2014-01-22 | 易金阳 | Wrinkle-removing, anti-ageing, skin-activating, restoring and whitening composition |
| CN103908424A (en) * | 2014-03-03 | 2014-07-09 | 奥思达干细胞有限公司 | Beautifying and nursing essence and preparation method thereof |
| CN105193676A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Acne removing composition |
| CN105596285A (en) * | 2015-11-19 | 2016-05-25 | 刘颖 | Wrinkle-eliminating nutrient solution |
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Application publication date: 20191018 |