CN110327443A - A kind of herbal mixture cataplasm that treating dog diarrhea and its production technology - Google Patents
A kind of herbal mixture cataplasm that treating dog diarrhea and its production technology Download PDFInfo
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Abstract
The present invention provides a kind of herbal mixture cataplasm for treating dog diarrhea and its production technology, is related to technical field of animal remedy preparation.The herbal mixture cataplasm is prepared jointly by Chinese medical concrete and cataplasm auxiliary material, and the Chinese medical concrete includes the material composition of following parts by weight: stoning 15 parts of dark plum, 25 parts of dry persimmon, 6 parts of terminalia flesh, 6 parts of the coptis, 6 parts of Radix Curcumae, 15 parts of humulus grass, 9 parts of granatum, 9 parts of Chinese waxmyrtle root, 6 parts of nutmeg；The cataplasm auxiliary material includes the material composition of following parts by weight: 3 parts of distilled water, 3 parts of gelatin, 4 parts of glycerol, 4 parts of Sodium Polyacrylate, 4 parts of Arabic gum, 5 parts of polyethylene glycol 400,0.3 part of azone, 0.2 part of zinc oxide.The present invention overcomes the deficiencies in the prior art, it is suitable for promoting the use of that made drug is by pasting abdomen infiltration administration, and cataplasm dose ingredient is controllable, osmotic absorption good effect small to skin irritation, blood concentration are stable, treatment prognosis bona.
Description
Technical field
The present invention relates to technical field of animal remedy preparation, and in particular to a kind of herbal mixture cataplasm for treating dog diarrhea and its
Production technology.
Background technique
Currently, the common method of pet dog treatment diarrhea has: 1. antiviral therapy: for pet dog virus diarrhea,
Antibiotic treatment secondary infection is given while using antiviral treatment, and gives immunization therapy to improve body resistance
Power.2. antibacterial therapy: antibacterial therapy is mainly used for for the bacterial diarrhea as caused by bacterium, common to have penicillin, phosphonomycin
Core capsule, gentamicin.3. helminth: needs, which are taken medicine, gets rid of intestinal parasites by means of drugs, and is which kind of parasitic infection with determination according to just inspection result,
Targetedly medication again.4. fluid-supplement therapy: the moisture and electrolyte of pet dog can be replenished in time.Generally treated using oral rehydration
The methods of method, vein fluid infusion.5. for the treatment of indigestion and enteritis.
In recent years, the diarrhea of dog is the highest common disease of disease incidence in pets hospital clinical case, although treating dog at present
There are many drug of diarrhea, but mostly use antibiotics.Antibiotic long-time service will cause intracorporal residual and generation drug resistance
Problem not only damages the body of dog, while certain harm is also caused to the health of consumer.The west of all treatment diarrhea
Minority causes secondary diarrhea after medicine or Chinese medicine are taken for a long time, it is also possible to generate drug dependence.
Antiviral therapy and antibacterial therapy are mainly using injection or the method for taking Western medicine, and Western medicine is more toxic, for a long time
Serious sequelae can be even generated using will cause internal medicament residue.Parasitic treatments and fluid-supplement therapy feelings in need of consideration
Condition is complex, to formulate detailed scheme according to the situation of individual, expend time and manpower.
Bar cloth patch is also known as cataplasm (Gatap lasma), is using water soluble polymer as matrix scaffold material
External use plaster, be to grow up from ancient times poultice.Since Japan's the 1970s carries out industrialized production, Ba Bu
Agent has faster development in Japan, and European & American Market has successfully been squeezed into the eighties, and the same period introduces China.Belong to it is transdermal to
One kind of medicine system or transdermal formulation.Bar cloth patch is usually made of back sheet, drug depot, protective film.Drug delivery system
Composition material be: back sheet is often new medical non-woven fabrics；Drug depot be in (west) drug powder or traditional Chinese medicine extraction medicinal extract
It is dispersed in bar cloth patch gel matrix；Protective film often uses polyethylene composite film, painting silicon paper film etc..Compared with other dosage forms, Ba Bu
The first pass effect and drug that agent has the advantage that avoidable liver and avoid caused by oral administration in the inactivation of gastrointestinal tract
Blood concentration peak valley phenomenon, can reduce toxicity.Administration number of times is few, easy to use, targeting is strong, drugloading rate is big, stingless
Swash property, make suitable dosage forms of the cataplasm as Traditional Chinese medicine external patch without the advantages that anaphylaxis.
Just there is Chinese herbal medicine to be applied to pet from ancient times clinical.Compare Chinese herbal medicine and Western medicine, Chinese herbal medicine is safer, and Chinese herbal medicine
The multifunctionality having can treat various diseases while under rushing down.With the variation of pet cultivation social function, animal good fortune
Benefit, the demand of pet care city field alignment medicine will gradually increase, and pet surely will be along with pet market with Chinese herbal medicine industry
Expansion welcome bigger development space.
Summary of the invention
In view of the shortcomings of the prior art, the present invention provides a kind of herbal mixture cataplasm for treating dog diarrhea and its production work
Skill, made drug is by pasting abdomen infiltration administration, and cataplasm dose ingredient is controllable, osmotic absorption small to skin irritation
Good effect, blood concentration are stable, treat prognosis bona, are suitable for promoting the use of.
In order to achieve the above object, technical solution of the present invention is achieved by the following technical programs:
A kind of herbal mixture cataplasm for treating dog diarrhea, the herbal mixture cataplasm are auxiliary by Chinese medical concrete and cataplasm
Help material to prepare jointly, the Chinese medical concrete includes the material composition of following parts by weight: 15 portions of dark plum of stoning, is scolded at 25 parts of dry persimmon
6 parts of sub- meat, 6 parts of the coptis, 6 parts of Radix Curcumae, 15 parts of humulus grass, 9 parts of granatum, 9 parts of Chinese waxmyrtle root, 6 parts of nutmeg；The cataplasm auxiliary
Material includes the material composition of following parts by weight: 3 parts of distilled water, 3 parts of gelatin, 4 parts of glycerol, 4 parts of Sodium Polyacrylate, Arabic gum
4 parts, 5 parts of polyethylene glycol 400,0.3 part of azone, 0.2 part of zinc oxide.
Preferably, the Chinese medical concrete and the mass ratio of cataplasm auxiliary material are 4: 23.5.
The production technology of the herbal mixture cataplasm the following steps are included:
(1) stoning dark plum, dry persimmon, terminalia flesh, the coptis, Radix Curcumae, humulus grass, granatum, poplar traditional Chinese medicine extraction: are weighed according to weight
Mei Gen, nutmeg mixing impregnate 2h after distilled water is added, and small fire continues to decoct 20min after being boiled by fire, filtering liquid medicine, then by medicine
Slag is added small fire after distilled water is boiled by fire again and decocts 20min, filters while hot, merges filtrate twice, it is standby to obtain compound Chinese medicine liquid
With；
(2) prepared by Chinese medical concrete: sodium benzoate is added in above-mentioned compound Chinese medicine liquid while hot, stirs evenly and is placed on electric heating drum
It is dried in wind drying box, it is spare to obtain Chinese medical concrete；
(3) auxiliary material pre-process: after gelatin is pulverized mix Arabic gum add distilled water carried out under water bath it is molten
It is swollen, polyethylene glycol 400, zinc oxide, glycerol, Sodium Polyacrylate and azone are successively added after swelling completely, are continued water-bath mixing and are stirred
It mixes uniformly, it is spare to obtain mixed-matrix；
(4) prepared by cataplasm: above-mentioned Chinese medical concrete is added in mixed-matrix, is stirred evenly under heating water bath addition,
Mixed liquor is obtained, mixed liquor is coated on non-woven fabrics, after drying at room temperature, covers plastic film to get treatment dog diarrhea is arrived
Herbal mixture cataplasm.
Preferably, the amount that distilled water is added in the extraction of traditional Chinese medicine for the first time is 6.5 times of total medicinal material weight, second
The secondary amount that distilled water is added is 3.5 times of total quality of medicinal material.
Preferably, the liquid-to-solid ratio that sodium benzoate is added into filtrate in the step (2) is 500: 1, and Chinese medicine soaks after drying
The volume of cream is the 1/4 of former total medicinal material volume.
Preferably, the temperature of heating water bath is 80 DEG C in the step (3).
Preferably, the temperature of heating water bath is 50 DEG C in the step (4), and the time being stirred is 30min.
The present invention provides a kind of herbal mixture cataplasm for treating dog diarrhea and its production work and preparation method thereof, and existing
Technology is compared to advantage:
(1) present invention use relieving diarrhea with astringents, adjust taste, invigorating the spleen fortune it is wet for the rules for the treatment of, invigorating the spleen fortune it is wet for treat fall ill delay
Slowly, a kind of method of the diarrhea caused by the course of disease is longer, rushes down frequently etc..Invigorating the spleen transports wet treatment void diarrhea and more suits the medicine to the illness.According to certainly
Quasi- compound traditional Chinese medicine formula is prepared into cataplasm.The formula is ancient prescription, the dark plum relieving diarrhea with astringents in " fence herds bun proved recipe ", side, raw
Saliva quenches the thirst, and is main ingredient；It is adjuvant that myrobalan, dry persimmon, which hold back puckery large intestine,；Coptis heat-clearing and damp-drying drug antidiarrheal, the Radix Curcumae promoting flow of qi and blood circulation are adjutant.This
Project is on the basis of extractum rhei manufacture craft, using extraction process by water method, orthogonal test and experiment of single factor determine Chinese medicine and
The proportion of distilled water impregnates number and time, the optimal prescription for decocting number and time, and medicinal extract is made to propose rate optimization.
(2) cataplasm dose ingredient of the present invention is controllable, osmotic absorption good effect small to skin irritation, blood concentration are steady
Fixed and easy to use bar of cloth pastes abdomen infiltration administration, and Chinese herb compound treats prognosis bona.
(3) present invention treats canine diarrhea at cataplasm using by medicine preparation, is pasted by external skin
Mode is administered, and is effectively reduced administration difficulty, promotes canine usage comfort, at the same reduce canine to such dependence for wanting object and
Drug resistance, enhancing use sense organ and using effect, are suitable for promoting the use of.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below with reference to the embodiment of the present invention pair
Technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is a part of the invention
Embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making wound
Every other embodiment obtained under the premise of the property made labour, shall fall within the protection scope of the present invention.
Embodiment 1:
A kind of production of herbal mixture cataplasm that treating dog diarrhea, the production technology of the herbal mixture cataplasm include
Following steps:
(1) stoning dark plum 5g, dry persimmon 25g, terminalia flesh 6g, coptis 6g, Radix Curcumae 6g, humulus traditional Chinese medicine extraction: are weighed according to weight
Careless 15g, granatum 9g, Chinese waxmyrtle root 9g, nutmeg 6g mixing are added small fire after distilled water is boiled by fire and continue to decoct 20min, mistake
Medical fluid is filtered, then small fire after distilled water is boiled by fire again is added in the dregs of a decoction and decocts 20min, is filtered while hot, is merged filtrate twice, obtain
Compound Chinese medicine liquid is spare；
(2) prepared by Chinese medical concrete: sodium benzoate is added in above-mentioned compound Chinese medicine liquid while hot, stirs evenly and is placed on electric heating drum
It is dried in wind drying box, it is spare to obtain Chinese medical concrete；
(3) auxiliary material pre-processes: mixing 40g Arabic gum after 30g gelatin is pulverized and adds 30ml distilled water in water-bath ring
It is swollen under border, successively adds 50g polyethylene glycol 400,2g zinc oxide, 40g glycerol, 40g Sodium Polyacrylate after swelling completely
With 3g azone, continues water-bath and be mixed evenly, it is spare to obtain mixed-matrix；
(4) prepared by cataplasm: above-mentioned Chinese medical concrete is added in mixed-matrix, is stirred evenly under heating water bath addition,
Mixed liquor is obtained, mixed liquor is coated on non-woven fabrics, after drying at room temperature, covers plastic film to get treatment dog diarrhea is arrived
Herbal mixture cataplasm.
Wherein, the quality is than Chinese medical concrete: distilled water: gelatin: glycerol: Sodium Polyacrylate: Arabic gum: polyethylene glycol
400: azone: zinc oxide=4: 3: 3: 4: 4: 4: 5: 0.3: 0.2；The amount of distilled water is added in the extraction of traditional Chinese medicine for the first time
It is 6.5 times of total medicinal material weight, the amount of second of addition distilled water is 3.5 times of total quality of medicinal material；Benzene first in the step (2)
The liquid-to-solid ratio that sour sodium is added into filtrate is 500: 1, and the volume of Chinese medical concrete is the 1/4 of former total medicinal material volume after drying；It is described
The temperature of heating water bath is 80 DEG C in step (3)；The temperature of heating water bath is 50 DEG C in the step (4), and be stirred
Time is 30min.
Embodiment 2:
According to Chinese Pharmacopoeia standard (2015 editions) quality standard, the preparation gained bar cloth patch of above-described embodiment 1 is carried out outer
See shape evaluation, adhesion strength detection and weight differential evaluation.Adhesion strength is measured, is affixed on phenolic aldehyde flitch with cataplasm, is glued
Area be 3cm × 3cm, measured with tensiometer, when being pulled to sample disengaging plate, record data afterwards.Cataplasm stability test: by sample
Product set 37 DEG C of relative temperature, in the constant temperature constant humidity baking oven of humidity 75%, place 4, measure adhesion strength after taking out sample.
Wherein appearance evaluation result are as follows: cataplasm color is dark brown, and external form is the Coin shape that diameter is 3cm, and surface is rich
Glossy, the slightly elastic and certain viscosity of sense of touch is applied on the square non-woven fabrics that side length is 7cm.
Adhesion strength detection: taking cataplasm 8 to open at random, and every group 2 is opened, and is divided into four groups, and sample is pasted on phenolic aldehyde flitch,
The area of adhesion is the area of cataplasm, first starts tensiometer, record measurement when cataplasm being then pulled to disengaging plate
Data.The average value that test measures peel strength is 460g, and matrix, which is affixed on skin, can be good at fixation, not flexible type.
Weight differential detection: 30 1 Bastian-Bruns agents of above-described embodiment are taken, are divided into three groups, every group 10 is opened.Precise weighing
Afterwards, weight range is in 4.7-5.3g, and weight differential value is less than 7%.
Embodiment 3:
Medication curative effect and mechanism, the detection mode for detecting above-mentioned cataplasm are as follows:
(1) experimental animal: selecting adult healthy China rural area dog 12, and male and female each 6.It is immunized using pentavaccine
(Wuxing Animal Health Pharmaceutical Plant, Jilin Prov.'s production)；Using ivermectin injection expelling parasite, (Anhui Tian An biotechnology share is limited
Company, authentication code: veterinary drug word (2015) 120482645, credit number: (2014) veterinary drug production card word 12048).Test
Dog feeds full dog phase chicken oat dog grain (production of Xingtai Ao Pai pet food Co., Ltd), feeds once, is not limited sooner or later daily
Drinking-water.
(2) test method: being divided into control group by weight phase approximately principle for 12 Chinese rural area dogs and give cataplasm group, and every group
Male and female each three, at the 0th day, feeding anhydrous sodium sulfate (Kingsoft chemical plant) 15g was made as Diarrhea Model to all test dogs,
Dog grain, free water are normally fed afterwards.Control group does not give cataplasm, gives bar cloth patch 7 days to cataplasm group, every morning
11:00 abdomen is pasted to cataplasm one, and every patch size is 7x7cm, weighs about 5.0g.
In test the 0th, 1,8d weighing dog weight, 12h is prohibited before blood sampling.It (is produced with disposable venous blood sample collection needle
Product standard: YZB/ Shandong 0118-2009) jugular vein blood collection, it is passed through disposable vacuum blood collection container (additive-free), 2ml blood
Amount.Ca and Mg content is measured using auspicious BS-200 automatic clinical chemistry analyzer is stepped；Na, K kit are measured by operation instructions.
(3) data analyze: test data using SPSS17.0 for windows analyze, using independent sample T examine with
The single factor test ANOVA method of inspection indicates data with means standard deviation (M ± SD).
Table 1: the comparison (M ± SD, n=6) of each group weight
| Group | 0th day | 1st day | 8th day |
| Control group weight | 3.9±0.22 | 4.1±0.99 | 4.45±1.26 |
| Administration group weight | 3.7±0.85 | 3.43±0.25 | 3.9±0.49 |
Control group and administration group measured the weight of 12 dogs at the 0th day, the 1st day and the 8th day respectively.According to the number in table 1
According to that can obtain, in control group, 8d is compared with 0d, and weight is without significant changes (P > 0.05)；In administration group, 8d is the same as the 0d pairs
Than weight is without significant changes (P > 0.05)；In 8d, control group and administration group comparison, weight is without significant changes (P > 0.05)；From
Data are not it is found that significant (P > 0.05) from quasi- influence of the Bastian-Bruns agent to dog weight.
During test, the dog state of mind of administration group and control group is energetic；Movement is normal, give stimulate the reaction compared with
Fastly.0d control group and administration group dog excrement state: bar shaped excrement, it is cylindrical, it is in yellow.1d control group and administration
Group dog excrement state: liquid, liquid dung have separation, are in yellowish-brown.2d control group and administration group dog excrement state: viscous
Thick, excrement is half congealed, does not form, and liquid dung is without separation, and color is brown, and part dog has only occurred can molding soft excrement.5d control
Group and administration group dog excrement state: excrement is softer, can still form, cylindrical, and color is yellowish-brown.7d control group dog is only
Excrement state: it is softer, it can still form, yellowish-brown；Administration group excrement state: it is more dry and hard, it can form, color is in yellow, external form
Strip.
Table 2: the partial results of each group blood testing compare (M ± SD, n=6)
Note: *, * * respectively indicate the level difference conspicuousness of same a line；Large and small female level for respectively indicating same row of writing
The significance of difference.
It can be obtained by the analysis of table 2, to higher magnesium ion, potassium ion in dog blood after Bastian-Bruns agent abdomen administration of the present invention
The influence that concentration is reduced has the influence increased to lower Na ion concentration, and influences more significant.That is medicament of the present invention abdomen
Influence after portion's administration to magnesium ion, potassium ion and Na ion concentration in dog blood reduces magnesium ion and potassium in the normal range
Ion concentration increases Na ion concentration.By dog, experiments have shown that, cataplasm can promote diarrhea dog body sodium, potassium, magnesium ion dense
The relative equilibrium of degree, the influence to body calcium ion concentration is unobvious, can alleviate diarrhea by reducing excrement water content and playing
Effect.Simultaneously by glutamic-oxalacetic transaminease AST, alkaline phosphatase, blood glucose GLU, total protein TP, urea UREA, cholesterol
The influence of TC, albumin A LB, uric acid UA, glutamic-pyruvic transaminase ALT etc. reach the protective effect to canine liver, and reduction was administered
Injury of the journey to canine promotes drug safety.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that
There is also other identical elements in process, method, article or equipment including the element.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features；And these modification or
Replacement, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (7)
1. a kind of herbal mixture cataplasm for treating dog diarrhea, which is characterized in that the herbal mixture cataplasm is by Chinese medical concrete
Prepare jointly with cataplasm auxiliary material, the Chinese medical concrete includes the material composition of following parts by weight: 15 parts of dark plum of stoning is done
25 parts of persimmon, 6 parts of terminalia flesh, 6 parts of the coptis, 6 parts of Radix Curcumae, 15 parts of humulus grass, 9 parts of granatum, 9 parts of Chinese waxmyrtle root, 6 parts of nutmeg；It is described
Cataplasm auxiliary material includes the material composition of following parts by weight: 3 parts of distilled water, 3 parts of gelatin, 4 parts of glycerol, Sodium Polyacrylate 4
Part, 4 parts of Arabic gum, 5 parts of polyethylene glycol 400,0.3 part of azone, 0.2 part of zinc oxide.
2. a kind of herbal mixture cataplasm for treating dog diarrhea according to claim 1, it is characterised in that: the Chinese medicine leaching
Cream and the mass ratio of cataplasm auxiliary material are 4: 23.5.
3. a kind of production technology for the herbal mixture cataplasm for treating dog diarrhea, it is characterised in that: the herbal mixture cataplasm
Production technology the following steps are included:
(1) stoning dark plum, dry persimmon, terminalia flesh, the coptis, Radix Curcumae, humulus grass, granatum, red bayberry traditional Chinese medicine extraction: are weighed according to weight
Root, nutmeg mixing impregnate 2h after distilled water is added, and small fire continues to decoct 20min after being boiled by fire, filtering liquid medicine, then by the dregs of a decoction
Small fire after distilled water is boiled by fire again is added and decocts 20min, filters while hot, merges filtrate twice, it is spare to obtain compound Chinese medicine liquid；
(2) prepared by Chinese medical concrete: sodium benzoate is added in above-mentioned compound Chinese medicine liquid while hot, stirs evenly that be placed on electric heating air blast dry
It is dried in dry case, it is spare to obtain Chinese medical concrete；
(3) auxiliary material pre-processes: mixing Arabic gum adds distilled water and is swollen under water bath after gelatin is pulverized, molten
It is swollen completely after successively add polyethylene glycol 400, zinc oxide, glycerol, Sodium Polyacrylate and azone, continue water-bath be mixed it is equal
It is even, it is spare to obtain mixed-matrix；
(4) prepared by cataplasm: above-mentioned Chinese medical concrete being added in mixed-matrix, stirs evenly, obtains mixed under heating water bath addition
Liquid is closed, mixed liquor is coated on non-woven fabrics, after drying at room temperature, covers plastic film to get the compound for the treatment of dog diarrhea is arrived
Chinese medicine patcher.
4. a kind of production technology of herbal mixture cataplasm for treating dog diarrhea according to claim 3, it is characterised in that:
The amount that distilled water is added in the extraction of traditional Chinese medicine for the first time is 6.5 times of total medicinal material weight, and distilled water is added for the second time
Amount is 3.5 times of total quality of medicinal material.
5. a kind of production technology of herbal mixture cataplasm for treating dog diarrhea according to claim 3, it is characterised in that:
It is 500: 1 that sodium benzoate, which is added into the liquid-to-solid ratio of filtrate, in the step (2), and the volume of Chinese medical concrete is former total medicine after drying
The 1/4 of material volume.
6. a kind of production technology of herbal mixture cataplasm for treating dog diarrhea according to claim 3, it is characterised in that:
The temperature of heating water bath is 80 DEG C in the step (3).
7. a kind of production technology of herbal mixture cataplasm for treating dog diarrhea according to claim 3, it is characterised in that:
The temperature of heating water bath is 50 DEG C in the step (4), and the time being stirred is 30min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114632110A (en) * | 2022-04-20 | 2022-06-17 | 安徽科技学院 | Navel patch for puppies and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114632110A (en) * | 2022-04-20 | 2022-06-17 | 安徽科技学院 | Navel patch for puppies and preparation method and application thereof |
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Application publication date: 20191015 |