CN1032571C - Plaster for preventing and treating infant's diarrhoea and anorexia and preparing process thereof - Google Patents
Plaster for preventing and treating infant's diarrhoea and anorexia and preparing process thereof Download PDFInfo
- Publication number
- CN1032571C CN1032571C CN93104666A CN93104666A CN1032571C CN 1032571 C CN1032571 C CN 1032571C CN 93104666 A CN93104666 A CN 93104666A CN 93104666 A CN93104666 A CN 93104666A CN 1032571 C CN1032571 C CN 1032571C
- Authority
- CN
- China
- Prior art keywords
- plaster
- apositia
- fine powder
- diarrhea
- infantile diarrhea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011505 plaster Substances 0.000 title claims abstract description 12
- 206010012735 Diarrhoea Diseases 0.000 title abstract description 9
- 206010061428 decreased appetite Diseases 0.000 title description 2
- 208000022531 anorexia Diseases 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 16
- 229940079593 drug Drugs 0.000 claims abstract description 8
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940099259 vaseline Drugs 0.000 claims abstract description 7
- 239000002390 adhesive tape Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000010298 pulverizing process Methods 0.000 claims abstract 2
- 239000000843 powder Substances 0.000 claims description 17
- 208000019637 Infantile Diarrhea Diseases 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000000341 volatile oil Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000000748 compression moulding Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000002932 luster Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 235000011837 pasties Nutrition 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- 229940126678 chinese medicines Drugs 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- -1 through decocting Substances 0.000 claims description 2
- 239000012567 medical material Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 101100433727 Caenorhabditis elegans got-1.2 gene Proteins 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 abstract description 4
- 208000019902 chronic diarrheal disease Diseases 0.000 abstract description 3
- 201000006549 dyspepsia Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 230000006870 function Effects 0.000 abstract description 3
- 208000019790 abdominal distention Diseases 0.000 abstract description 2
- 201000009840 acute diarrhea Diseases 0.000 abstract description 2
- 208000004998 Abdominal Pain Diseases 0.000 abstract 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 244000061408 Eugenia caryophyllata Species 0.000 abstract 1
- 239000004166 Lanolin Substances 0.000 abstract 1
- 235000019510 Long pepper Nutrition 0.000 abstract 1
- 240000003455 Piper longum Species 0.000 abstract 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract 1
- 230000036528 appetite Effects 0.000 abstract 1
- 235000019789 appetite Nutrition 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 229960005150 glycerol Drugs 0.000 abstract 1
- 229940039717 lanolin Drugs 0.000 abstract 1
- 235000019388 lanolin Nutrition 0.000 abstract 1
- 238000007493 shaping process Methods 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 231100000017 mucous membrane irritation Toxicity 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a plaster which belongs to the category of medicines. Clove, cinnamon, long pepper, vaseline, lanolin, glycerine and azone are used as raw materials, and is processed through decoction, concentration, pulverization, blending, shaping through pressing and cooling, the raw materials are stuck to adhesive tapes and the plaster is made. The present invention has the functions of strengthening the spleen, warm the middle warmer, dispelling cold to relieve diarrhea, mainly cures infantile poor appetite, dyspepsia, acute diarrhea, chronic diarrhea, abdominal distention, bellyache and slight gastrointestinal illness, can also be used for women dysmenorrhea and quinquagenarian diarrhea before dawn, has easy use and obvious effect, solves the shortage that oral medicines are not suitable for infants, and is really an effective medicine for infants.
Description
The invention belongs to the category of medicine, relate to a kind of control infantile diarrhea, apositia one plaster and preparation method thereof specifically.
Infant acute and chronic diarrhea, apositia are usual diseases of childhood, are having a strong impact on the normal development and the health of infant." children's is rushed down speed and stopped ", " XIAOSHI PIAN " can be treated infantile diarrhea, dyspepsia, are the standing medicines in the family.But the weak point of this medicine is: make troubles to use, it is medication for oral administration, often because of child does not eat, cries and screams, and brings great worry to the head of a family, also often because of food dose deficiency, brings not good therapeutic effect.
The object of the present invention is to provide a kind of easy to use, accurate measurement, control infantile diarrhea evident in efficacy, apositia one plaster and preparation method thereof.
The present invention is to be raw material with Flos Caryophylli, Cortex Cinnamomi, Fructus Piperis Longi, vaseline, lanoline, glycerol, azone, through decocting, concentrate, pulverize, transfer platform, compression moulding, cool off, sticking on the adhesive tape and make.
The hot temperature of Flos Caryophylli, Cortex Cinnamomi is hot, both promoting the flow of QI-blood by warming the meridian, regulating the function of the stomach to resolve the turbidity, Fructus Piperis Longi is hot, the intestines and stomach cold-evil that can loose, vaseline, lanoline are substrate, and glycerol is plasticizer, and azone is a transdermal agent.Medicine sticks umbilical part, and umbilical part has another name called Shenque, the saturating spleen kidney of gas, and the efficacy of a drug can reach the spleen kidney whereby, plays the effect of preventing and curing diseases.
Preparation technology of the present invention is as follows:
Proportioning raw materials (weight ratio) is:
Flos Caryophylli: Cortex Cinnamomi: Fructus Piperis Longi=1: 0.5～1.5: 0.01
Take by weighing three flavor Chinese medicines by charge ratio, mixing after concocting, getting 1/5～4/5 of its total amount adds the water distillation and collects volatile oil, decoct then twice, each 2 hours, filter, merging filtrate, simmer down to relative density are that the clear paste of 1.20～1.25 (60 ℃) is standby, and all the other Chinese medicine powders of 1/5～4/5 are broken into 80～140 purpose fine powders, clear paste is admixed in the above-mentioned fine powder equably, put into baking oven, carrying out drying below 6O ℃, water content is reached below 6%, discharging is cooled to and is ground into 80～140 purpose fine powders after the room temperature and weighs.The vaseline, lanoline that respectively account for glycerol, the azone of fine powder weight 1% and account for fine powder weight 50%～100% are added in the fine powder, under 60～80 ℃ condition, stir into pasty state, under 55～60 ℃ condition, the volatile oil of collecting is joined in the paste then, the limit edged stirs, after waiting to be the uniform paste of color and luster, compression moulding, cooling sticks on the adhesive tape, packing promptly gets product.
Specification: every subsides dose is 0.5～2.5 gram, and the best is 1.2 grams.
Character: this product is a dark brown semicircle spheroid ointment, fragrant odour.
Function and curing mainly: the spleen invigorating warming middle-JIAO, cold expelling antidiarrheal, control infant inappetence, dyspepsia and acute and chronic diarrhea, abdominal distention, stomachache, gastrointestinal upset also can be used for dysmenorrhes and person in middle and old age diarrhea before dawn.
Usage and dosage: be affixed on umbilical part, one time one subsides, 2～3 are once.
Advantage of the present invention:
Show by pharmacodynamics test that 1, this medicine has the effect that improves the animal body resisting fatigue and improve body endurance.
2, show the performance of this medicine avirulence by animal acute toxicity test.
3, show this medicine nonirritant, no sensitization by skin irritation, mucous membrane irritation and sensitization of skin test.
4, by the 780 routine administration clinical observations over 2 years of four provincial hospitals, this medicine cure rate is 85.90%, total effective rate 95.77%, and evident in efficacy, medication is easy, and is safe and reliable, solved the deficiency of the unsuitable oral drugs of infant.
Embodiment:
Flos Caryophylli 500 grams, Cortex Cinnamomi 400 grams, Fructus Piperis Longi 5 grams, mixing after concocting, getting 3/5 of its total amount is that 543 grams add the water distillation, collects volatile oil 1.5 grams, decocts twice then, each 2 hours, filter, merging filtrate, being condensed into relative density is the clear paste of 1.23 (60 ℃), must measure 160.5 grams.All the other 2/5 promptly 362 grams be ground into 80 purpose fine powders, 356 grams.Clear paste is admixed in the fine powder equably, put under the condition of 58 ± 2 ℃ of baking oven inherences and dry, reach at 6% o'clock to water content, discharging is cooled to room temperature, is ground into 100 purpose fine powders again, and weighing gets 505.2 grams.
The vaseline of the azone of the glycerol of 5.1 grams and 5.1 grams and 404 grams and lanoline are added in the fine powder, stir into pasty state under 65 ± 2 ℃ condition, when being cooled to 57 ± 2 ℃ volatile oil 1.5 grams are added in the paste, the limit edged stirs, make to be the uniform paste of color and luster, weighing gets 920 grams.Get 1.2 grams for a, compression moulding, cooling sticks on the PVC medical adhesive tape, packing.
Claims (4)
1, a kind of control infantile diarrhea, apositia one plaster, it is characterized in that: with Flos Caryophylli, Cortex Cinnamomi, Fructus Piperis Longi, vaseline, lanoline, glycerol, azone is raw material, through decocting, concentrate, pulverizing, blending, compression moulding, cooling off, stick on the adhesive tape and make, its active drug proportioning raw materials is (weight ratio):
Flos Caryophylli: Cortex Cinnamomi: Fructus Piperis Longi=1: 0.5～1.5: 0.01
2, a kind of control infantile diarrhea according to claim 1, apositia one plaster is characterized in that: it is 0.5～2.5 gram that every dose of plaster contains the total dose of ointment that medical material, medicinal substances extract and substrate makes.
3, a kind of control infantile diarrhea according to claim 1, apositia one plaster is characterized in that: it is 1.2 grams that every dose of plaster contains the total dose of ointment that medical material, medicinal substances extract and substrate makes.
4, the preparation method of the described control infantile diarrhea of production claim 1, apositia one plaster is characterized in that:
(1), by proportioning take by weighing three the flavor Chinese medicines, mixing through concocting after is got 1/5～4/5 of its total amount and is added the water distillation and collect volatile oil, decocts twice then, each 2 hours, the filtration, merging filtrate, the simmer down to relative density is the clear paste of 1.20～1.25 (60 ℃);
(2), all the other remainders of 1/5～4/5 are ground into 80～140 purpose fine powders;
(3), clear paste is admixed in the above-mentioned fine powder equably, put into baking oven, carrying out drying below 60 ℃, water content is reached below 6%, discharging is cooled to and is ground into 80～140 purpose fine powders after the room temperature and weighs;
(4), the vaseline, lanoline that will respectively account for glycerol, the azone of fine powder weight 1% and account for fine powder weight 50～100% adds in the fine powder, under 60～80 ℃ condition, stir into pasty state, then under 55～60 ℃ of conditions, the volatile oil of collecting is slowly joined in the paste, and the limit edged stirs, wait to be the uniform paste of color and luster after, compression moulding, cooling sticks on the adhesive tape, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93104666A CN1032571C (en) | 1993-04-24 | 1993-04-24 | Plaster for preventing and treating infant's diarrhoea and anorexia and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93104666A CN1032571C (en) | 1993-04-24 | 1993-04-24 | Plaster for preventing and treating infant's diarrhoea and anorexia and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1094621A CN1094621A (en) | 1994-11-09 |
| CN1032571C true CN1032571C (en) | 1996-08-21 |
Family
ID=4985266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93104666A Expired - Lifetime CN1032571C (en) | 1993-04-24 | 1993-04-24 | Plaster for preventing and treating infant's diarrhoea and anorexia and preparing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1032571C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285275A (en) * | 2013-06-18 | 2013-09-11 | 冯宇伟 | Medicament for preventing and treating atherosclerosis and preparation method thereof |
| CN103285277A (en) * | 2013-06-18 | 2013-09-11 | 冯宇伟 | Umbilical sticking agent for reducing weight and preparation method thereof |
| CN104523848B (en) * | 2014-12-31 | 2017-10-03 | 亚宝药业集团股份有限公司 | A kind of invigorating the spleen middle benefit gas, the preparation method of the pharmaceutical composition of cold dispelling antidiarrheal |
-
1993
- 1993-04-24 CN CN93104666A patent/CN1032571C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1094621A (en) | 1994-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1899543B (en) | External plaster for treating child fever and preparing method | |
| CN100450540C (en) | External plaster for treating child cold type cough and preparing method | |
| CN103766908B (en) | A kind of health Chu chrysanthemum buccal tablet and production method thereof | |
| CN1255168C (en) | External plaster for treating baby heat cough and preparing method | |
| CN1032571C (en) | Plaster for preventing and treating infant's diarrhoea and anorexia and preparing process thereof | |
| CN115414435B (en) | Chinese herbal compound Ge Houdan poria cocos granule and preparation method and application thereof | |
| CN102028927B (en) | Externally applied emplastrum for treating anxious chronic bronchitis and preparation method thereof | |
| CN101015598A (en) | Externally used pharmaceutical preparation for treating disease caused by acarids | |
| CN101036749A (en) | External emplastrum for treating asthenic fever for children and the preparing method | |
| CN104147186B (en) | Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof | |
| CN105288501A (en) | Traditional Chinese medicine composition containing folium artemisiae argyi and treating obesity | |
| CN101721557B (en) | Chewing gum for curing dental ulcer and preparation method thereof | |
| CN114259540B (en) | Traditional Chinese medicine composition for treating diabetes with syndrome of deficiency of both qi and yin and preparation method and application thereof | |
| CN110720527A (en) | Traditional Chinese medicine weight-losing tea | |
| CN109999167A (en) | A kind of Chinese medicine composition having both conditioning mood and health of losing weight | |
| CN110025749A (en) | A kind of Chinese medicine composition with hair care and nourishing health-preserving function | |
| CN109847006A (en) | A kind of Chinese herbs paste and preparation method thereof for treating children's wind-heat cold | |
| CN1044198C (en) | Prescription of weifuyuan capsule and its preparation method | |
| CN102755635A (en) | Composition for improving gastrointestinal function and preparation method thereof | |
| CN106955348A (en) | Chinese medicine composition and preparation method for treating chronic nephritis | |
| CN118593641A (en) | A Chinese medicinal patch with antipyretic effect, and its preparation method | |
| CN1131029A (en) | Traditional Chinese medicine for curing chronic rhinitis and its preparation method | |
| CN104740487B (en) | A kind of Chinese medicine composition for treating children anorexia and preparation method thereof | |
| CN105641633A (en) | Application of Chinese herbal medicine preparation in preparing medicine for treating obesity | |
| CN105250816A (en) | Medicine composition for treating phlegmatic hygrosis and preparation method and application of medicine composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C53 | Correction of patent of invention or patent application | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: PATENTEE; FROM: RUICHENG LOCALLY-ADMINISTERED STATE PHARMACEUTICAL FACTORY, SHANXI PROV. TO: RUICHENG PHARMACEUTIC FACTORY, SHANXI PROV. |
|
| CP01 | Change in the name or title of a patent holder |
Patentee after: Ruicheng Pharmaceutical Factory, Shanxi Prov. Patentee before: Ruicheng Locally-administered State Pharmaceutical Factory, Shanxi Prov. |
|
| IP01 | Partial invalidation of patent right |
Case number: W40297, W40353 Conclusion of examination: The claims 1-3104666.1 of the invention patent claims 1-3 is invalid and the maintenance of claim 4 is valid. Decision date: 20030102 Denomination of invention: Prevention and treatment of infant diarrhea, anorexia and its preparation Granted publication date: 19960821 Int.cl.7: A61K35/78 Patentee: Ruicheng Pharmaceutical Factory, Shanxi Prov. Review decision number: 5711 Decision date of declaring invalidation: 20030102 Decision number of declaring invalidation: 5711 |
|
| C56 | Change in the name or address of the patentee |
Owner name: RUICHENG XINYUSHENG TECHNOLOGY CO., LTD. Free format text: FORMER NAME OR ADDRESS: RUICHENG PHARMACEUTIC FACTORY, SHANXI PROV. |
|
| CP03 | Change of name, title or address |
Address after: 044600 No. 43 East Ring Road, Ruicheng County, Shanxi Patentee after: Ruicheng Xinyusheng Technology Co.,Ltd. Address before: 044600 No. 43 East Ring Road, Ruicheng County, Shanxi Patentee before: Ruicheng Pharmaceutical Factory, Shanxi Prov. |
|
| C56 | Change in the name or address of the patentee |
Owner name: SHANXI YABAO INVESTMENT CO., LTD. Free format text: FORMER NAME: RUICHENG XINYUSHENG TECHNOLOGY CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: 044600 Shanxi province Ruicheng County sub Po No. 41 Patentee after: Shanxi Asia Investment Ltd. Address before: 044600 No. 43 East Ring Road, Ruicheng County, Shanxi Patentee before: Ruicheng Xinyusheng Technology Co.,Ltd. |
|
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20130424 Granted publication date: 19960821 |