CN110327410A - A kind of compound formulation of suitable spacefarer - Google Patents

Abstract

The present invention relates to the compound formulation of suitable spacefarer a kind of, said preparation is made of following raw material: sea cucumber, ginseng, fructus lycii, longan, raspberry, Poria cocos, Chinese yam, xylitol.Preparation of the invention for spacefarer during space flight, the systema cariovasculare functional decline that causes due to space flight particular surroundings, hypoimmunity and the preparation researched and developed, mainly to systema cariovasculare functional, the integrally-regulated purpose with protection of immunity.

Description

A kind of compound formulation of suitable spacefarer

[technical field]

The present invention relates to a kind of pharmaceutical formulations, in particular to a kind of to be directed to spacefarer during space flight, since space flight is special Systema cariovasculare functional decline that environment causes, hypoimmunity and the pharmaceutical formulation and production technology researched and developed.

[background technique]

With the development of space flight, food starts to be widely used in space industry, and achieves good effect.Painstaking effort One of major obstacle when pipe function reduction is spacefarer's execution space task.Cardiovascular system can carry out certainly under normal circumstances I is adjusted to adapt to new environment, and the particular surroundings such as weightlessness of space make spacefarer's cardiovascular system get muddled, to make space flight Member cannot adapt to the particular surroundings of space quickly.Export becomes apparent from when working, and is mainly shown as plasma volume reduction, red blood cell The syndrome that the cardiovascular functions such as quality reduces, abnormal erythrocyte increases, hematocrit reduces reduce.In space flight process In, due to the influence of the factors such as microgravity, radiation, narrow living space, the immune function of spacefarer is suppressed, and leads to it The infringement of the bacterium and virus that are more easily hidden in or beyond the body in environment, still influences the function of other systems, such as Influence the generation and absorption of bone.It is therefore desirable to which a kind of compound preparation is made, carries, is convenient to take, reaching in space flight The integrally-regulated purpose with protection of the systema cariovasculare functional of spacefarer, immunity.

[summary of the invention]

The present invention is exactly in order to solve spacefarer during space flight, due to the cardiovascular system function of space flight environment initiation It can decline, hypoimmunity and the press sheet formulation formula researched and developed.

In order to achieve the object of the present invention, a kind of compound formulation of suitable spacefarer is with sea cucumber, ginseng, fructus lycii, dragon Eye, raspberry, Poria cocos, Chinese yam, xylitol are made.The component raw material weight ratio of said preparation is as follows:

Sea cucumber 10%-30%

Ginseng 10%~30%

Fructus lycii 5%-20%

Longan 5%~15%

Raspberry 10%~20%

Poria cocos 5%~25%

Chinese yam 5%~25%

Xylitol 1%-5%

Preferably:

Sea cucumber 25%

Ginseng 20%

Fructus lycii 6%

Longan 11%

Raspberry 11%

Poria cocos 11%

Chinese yam 6%

Xylitol 10%

Specific production technology is as follows:

Poria cocos powder is sieved (50 mesh) at fine powder, spare；Sea cucumber, ginseng, fructus lycii, longan, raspberry, Chinese yam were soaked in water It after night, boils twice, for the first time 8 times of amount water, second of 6 times of amount water is boiled 2 hours for the first time, boiled for the second time 1 hour, merge twice Boil liquid, filtration is added Poria cocos fine powder, is sufficiently mixed Poria cocos fine powder and liquid topic, bored to set 6 hours, filling at doses Preparation, sterilization.

A kind of compound formulation of suitable spacefarer, sea cucumber effect:

Biological active calcium, sea cucumber mucopolysaccharide, polypeptide, holothurin, selenka, amino acid, isoreactivity ingredient in sea cucumber, can be effective Damaged articular cartilage is repaired, the normal function of Bones and joints is restored.Nutritional ingredient also has expansion blood vessel in sea cucumber simultaneously, increases blood Flow quantity;Inhibit platelet aggregation, the dissolution of reinforcing fiber albumen improves microcirculation;Inflammatory exudate is promoted to absorb;And there is town Bitterly, effect that is calm, anti-inflammatory, anti-infective, improving immunity of organisms.Methionine, taurine, trace element vanadium, selenium, germanium, dimension life Plain PP etc., these substances are all that growth in humans develops indispensable substance, and irreplaceable physiological function is played in body, Such as methionine, taurine, can enhancing development, relieve fatigue;Trace element vanadium can make ferro element in body more effective Absorption, improve various anaemias;Elemental selenium, germanium etc., which then have, removes human free radical, the effect of anti-cancer, anticancer.

1, brain tonic, intelligence development, longevity mind

Sea cucumber contains more than 50 kinds of natural nutrition compositions.Wherein acid mucopolysaccharide and chondroitin have the special efficacy to delay senescence.In addition, Manganese, taurine etc. all have unique function to human body anti-aging, and therefore, sea cucumber is also known as " long-lived mind ".It is diabetes, height The ideal diet good food of the patients such as blood pressure, coronary heart disease and cerebral thrombosis.

2, anticancer miracle -- sea cucumber

Holothurin, content is very high in the tissue such as body wall, internal organ and body of gland of sea cucumber.Holothurin is a kind of counterpoison, energy Inhibit the growth of certain cancer cells, while there are very strong Antifungal activities.Selenium contained in sea cucumber can inhibit cancer cell and blood The growth of pipe has apparent antitumaous effect.Sea cucumber has obvious curative effects to anticancer, has to growth, the transfer of malignant tumour aobvious Inhibiting effect is write, this is proved by Institute of Science.

3, the effect of sea cucumber is for pregnant woman

Ancient Times in China is civil just sea cucumber, and " enriching the blood to restore normal menstruation, menstruation regulating nourishing the fetus, midwifery are stimulated the secretion of milk, and essence and blood loss can be treated, and wound is not cured Disease " saying.Simultaneously it to postpartum, quickly regaining one's strength etc. has positive effect.It is pregnant by 100 pregnant woman's follow-up investigations 1000 grams of each beche-de-mer of woman, the baby of birth is retarded without an example, calcium deficiency, suffers from hepatitis B phenomenon, and hair brilliant black, milch tooth exceed the time limit It does not move back.

4, the best tonic of patient with operation

Someone once did comparative experiments, and two state of an illness are close, age and weight patient with operation very nearly the same, one edible daily The patient of sea cucumber can shift to an earlier date comprehensive rehabilitation in 20 days or so than another patient.Therefore, patients after surgery, puerpera, the outer injury of fracture Person, blood donor or other excessive blood loss persons, beche-de-mer are enriched blood, and are rebuild one's physical constitution, and are restored shape body, can be obviously shortened rehabilitation duration. Sea cucumber is referred to as " first of hundred benefits " and " mind of enriching blood ".

Sea cucumber mucopolysaccharide: this is the another kind of important component in wall of sea cucumber Stichopus japonicus, has effects that broad-spectrum anti-tumor, Neng Gouti High immunity of organisms, anti-inflammation detumescence.Meanwhile it or a kind of novel anti-coagulants, the hyperplasia of vascular smooth muscle can be inhibited, in raising Epithelial cell proliferation and migration, and stimulating endothelial cell discharges sequestered inhibitor, having to mid-aged population reduces blood viscosity Effect.

The effect of ginseng:

1, central nervous system is adjusted

Ginseng is adjustable central nervous system, improves excitement and the process of inhibition of brain, is allowed to tend to balance;Can improve it is mental with The ability of manual labor improves working efficiency, and plays the role of antifatigue.

2, promote utilization of the brain to energy matter

Can be improved enhances the effective component of learning and memory ability in ability of learning and memory ginseng be ginsenoside, wherein ginseng Saponin(e Rb1 and Rg1 have good influence to learning and memory function.Ginseng saponin(e learns normal rat, Memory Process has Facilitation, and ginsenoside improves significantly to Rats With Memory obstacle caused by electroconvulsive shock.Both make just The monoamine transmitter contents of the Different brain region of normal rat increased significantly.These research work, pairing ought to use ginseng plant resources There is some reference value.

3, improve cardiac function

Ginseng can increase myocardial contractive power, reducing heart rate, increase cardiac output and coronary blood flow, can resist myocardial ischemia and the rhythm of the heart It is not normal.It all has a certain impact to cardiac function, angiocarpy, blood flow.Ginseng has apparent resisting oxygen lack, and preparation can be effective It is not normal that ground fights sinus rate.Ginsenoside can accelerate lipid-metabolism, and have the function of being substantially reduced high cholesterol.It is low dose of Ginseng can be such that anesthetized animal blood pressure slightly rises, large dosage of then decline blood pressure.Different gen-sengs are to Isolated Toad Heart And all play the role of enhancing its function in body rabbit, cat, dog heart, and amyocardia when can improve its ventricular fibrillation.

4, hypoglycemic effect

Contain ginsenoside and panaxan in ginseng.Especially ginsenoside Rb2 has apparent hypoglycemic effect, furthermore ginseng Polysaccharide (or glycopeptide class) is another kind of blood sugar reducing component in ginseng.

5, enhance the immune function of body

Ginsenoside and panaxan are the active constituents that ginseng adjusts immune function, not only to normal person, and to immune function It lowly can be improved immunity function per capita.Panaxan is the polymeric acidic polysaccharide purified in ginseng, is that one kind is exempted from Epidemic disease reinforcing agent.It is observed by zoopery and human clinical trial, it was demonstrated that body immunity can be significantly increased, had to malignant tumour Certain curative effect;The visible same extension patient life span of clinical trial improves Immune Function, and mitigates radiotherapy Toxic side effect accelerates the reparation of injury tissue.Confirm by clinical observation: panaxan has apparent effect in increasing leukocyte, with Chemicotherapy is applied simultaneously, can reduce the toxic side effect of radiotherapy, and prevention oligoleukocythemia makes patient smoothly complete to treat.Using It is without side-effects during panaxan, it was demonstrated that the medicine is safe and reliable.

6, the resilience to destructive stimulus is improved, the stress ability and adaptability of body can be enhanced

Contain ginsenoside in ginseng, anti-stress effect can be improved.It can be with the ability of anti anoxia, high temperature resistant and low temperature.

7, antitumor action

Ginsenoside, panaxan, panacene's alcohols, panaxytiol and volatile oil substance in ginseng.These substances pair Tumour has certain inhibiting effect, but mechanism is sufficiently complex.

8, antioxidation

Containing there are many antioxidant, ginsenoside, ginseng polyacetylene class compound and Panaxadiol Saponin etc. in ginseng.These Compound has lipoid peroxidization resistant, is the basis of anti-aging effects.Other than anti-aging effects, to nerve, endocrine, exempt from The physiological functions such as epidemic disease function and metabolism have adjustment effect.In addition, ginseng also has antiviral, Hemorrhagic shock, weight-reducing etc. multi-party The effect in face.Although ginseng is the higher tonic of value, but not everybody is applicable in.Rho factor in ginseng can inhibit fat It decomposes, aggravates vascular wall lipidosis, therefore have coronary heart disease, hypertension, cerebrovascular sclerosis, diabetes, answer and careful take ginseng.Blood is viscous Consistency increases, and blood circulation can be made unsmooth, Chinese medicine is referred to as blood stasis.Ginseng plays the role of promoting red blood cell growth, and red blood cell increases More, blood station consistency can be higher.

The effect of fructus lycii is:

Its is sweet in flavor, mild-natured to have the effect of liver-kidney tonifying, says that " long term usage heavily fortified point muscles and bones is made light of one's life by commiting suicide not old, resistance to cold and heat in Compendium of Material Medica." Chinese medicine often treats liver-kidney Yin deficiency, soreness and weakness of waist and knees, dizziness, amnesia, dizzy, the more tears of blurred vision, the illnesss such as quench one's thirst, pass out semen with it.It is existing Body's immunity is adjusted for pharmaceutical research confirmation fructus lycii, can effectively inhibit tumour growth and cell mutation, have and prolong Slow aging anti-fatty liver, adjusts the effect of blood lipid and blood glucose, promotion hematopoiesis function etc., and is applied to clinic.Fructus lycii clothes With conveniently, it can be used as medicine, chew clothes, steep in wine.But exopathogen real heat, spleen deficiency have wet and diarrhea person to avoid clothes.

The effect of longan:

1, the fresh longan of intelligence development nourishing heart be it is a kind of can inhibit nourishing heart, the fruit of blood-enriching tranquillizing, natural fructose that it contains and more Kind microelement, can directly act on the brain and heart of the mankind, the neurasthenia that can alleviate the mankind also can be reduced nervous palpitaition And the common cardiacs disease such as heart infarction occurs.

2, the fresh longan of blood-supplementing blood-nourishing is a kind of rare food materials of enriching blood, glucose and protein that it contains and Trace elements iron can be absorbed and utilized by the body as early as possible, can improve bone marrow cell activity, promote hemoglobin synthesis in human body, Its energy tonifying Qi and blood is often eaten, can also alleviate anaemia, the ill symptoms of people's anaemia and sallow complexion can be allowed to improve quickly.

3, after usually people eat fresh longan, a kind of natural materials similar to collagen can be absorbed, it can be fast Speed is absorbed and is utilized by Skin Cell, can increase skin elasticity, delay skin aging, in addition to this, the organized enzyme that it contains is also The quantity of people's interior free yl can be reduced, each organ dysfunction of body can be improved, a variety of senile symptoms is delayed to occur.

4, contain a large amount of natural fructose and glucose in fresh longan, they can be rapidly converted into energy after entering human body Amount, is absorbed and utilized by the body, fatigue can be effectively relieved, and in addition to this, the microelement that it contains can also promote newborn in human body The metabolism of acid, and lactic acid is the important presence for inducing human-body fatigue, therefore people usually eat fresh longan and the mankind can be allowed quick It regains one's strength, reduces fatigue symptom.

The effect of raspberry:

1, bacteriostasis: 100% decoction is burrowed method with plate, has inhibiting effect to staphylococcus, also has inhibition to make comma bacillus With.

2, estrogen-like action: the indexs such as rat, the vaginal smear of rabbit and inner membrance slice show that raspberry seemingly has estrogen Sample effect.

3, antimutagenesis: test result, which discloses raspberry water-soluble extractive, has certain antimutagenesis, to cover basin Son exploitation provides certain scientific basis [2] at health food.Zhong Shi etc. study 22 kinds of edible wild plant mutagenesis such as Xinjiang with Antimutagenesis, the result shows that the wild plants antimutagenesis such as raspberry is most strong.

4, warming kidney and enhancing yang acts on: it is found through analysis, 17 kinds of amino acid is contained in the fruit and blade of Rubus chingii, 7 kinds of middle essential amino acid, polysaccharide, flavones wait compounds.It is edible to have warming kidney and enhancing yang effect.

5, it treats ophthalmology disease: there is the description of " tonifying liver empty and improving eyesight ", German scientific research personnel's research according to raspberry It was found that contain a large amount of antioxidant in raspberry, and this substance is after entering body, it is dense at the retina position of eyeball Degree is higher, can be effectively prevented retina oxidation, and remove the free radical having damage to retina.So raspberry can For protecting or improve eyesight, and the senile eye disease (such as macular degeneration illness) for the treatment of has remarkable effect.

6, brain tonic and intelligence development: the U.S. it was discovered by researchers that raspberry has the effect of brain tonic and intelligence development, active thinking.They Think, antioxidant contained in raspberry, damage of the free radical to brain can be effectively prevented, and improve brain blood and Oxygen supply, to have the function that brain tonic and intelligence development.

7, beautifying face and moistering lotion: Flavonoid substances contained in raspberry, in addition to antibacterial anti-inflammatory, reducing blood pressure and antiallergy The effects of outside, they also display consummate skill in terms of skin-protecting face nursing.This substance can improve skin blood circulation, enhance skin hair Thin blood vessel elasticity promotes Skin Cell regeneration, to play the function of beautifying face and moistering lotion.

8, anti-curing cancers: free radical is wreaked havoc such as ruffian in vivo, injury tissue cell, changes DNA molecular structure, thus Lead to the generation of cancer.Containing a kind of ingredient --- anthocyanin for being very useful to health in raspberry, it, which has, is removed certainly By base, the function of anti-curing cancers generation.Therefore, raspberry is of great significance for prevention and control of cancer.

9, establishing-Yang is emerging withers: the U.S. studies have shown that various active constituents contained in raspberry, can improve the blood of penis Liquid circulation, improves the excitability of nerve, so that weak penis is shone vitality, therefore raspberry is for preventing and treating male erectile function It can obstacle, sexual desire be indifferent etc. remarkable effect.

The effect of Poria cocos is:

1, diuresis

2, antibacterial action

3, to the influence of digestive system

4, blood glucose is reduced

5, to action of the heart

6, antitumor action

7, to the influence of immune function

(1) increase the cytotoxic effect of macrophage；

(2) mouse serum complement number and special antigen-binding cells number can be remarkably reinforced in methylol pachymaran；

(3) increase nonspecific acid esterase positive lymphocyte number；

(4) enhance the cytotoxicity of T lymphocyte；

8, to the influence of hematological system

9, the influence of Central nervous system

10, anticancer

11, air making-up and spleen enlivening

12, phlegm is controlled.

The effect of Chinese yam:

1, Chinese yam meat is pure white, containing nutrient necessary to the human bodies such as protein, vitamin, starch, calcium phosphorus, according to pharmacological research potato Glutinous polysaccharide in Chinese yam, can stimulate and adjust the immune system of human body, there is antitumor, antiviral, anti-aging.Mucus is more For sugar in conjunction with inorganic salts, can form sclerotin makes cartilage have certain elasticity.

2, the feature of Chinese yam maximum is containing a large amount of mucoprotein, this is a kind of mixture of proteinpolysaccharide, is had to human body Special health-care effect can prevent the sedimentation of fat on angiocarpy, keep the elasticity of blood vessel, prevent the too early of atherosclerosis Occur.The adjustable blood pressure of saponin, hypoglycemic, reducing blood lipid, inhibition tumour in Chinese yam.It is also beneficial to the protection of stomach simultaneously, Viscous texture specific to mucus can form one layer of protection to stomach wall, mitigate the pressure of stomach lining.

3, the effect of anesthesia is known as in Chinese yam containing allantois, epithelial growth can be promoted to play the antibacterial effect of anti-inflammatory, is used In adjuvant treatment rhagadia manus et pedis, ichthyosis etc..

The present invention passes through the functional state of structure adjusting people, and by replenishing vital essence and invigorating vital QI, lung, nourishing generate fluid, stagnation resolvation row are supported in invigorating the spleen Gas, promoting digestion and removing indigestion, heat-clearing are refreshed oneself, and improvement systema cariovasculare functional is reached, and improve the purpose of immunity.

[specific embodiment]

The raw material of this implementation is as follows:

Sea cucumber 25%

Ginseng 20%

Fructus lycii 6%

Longan 11%

Raspberry 11%

Poria cocos 11%

Chinese yam 6%

Xylitol 10%

Specific production technology is as follows:

Poria cocos powder is sieved (50 mesh) at fine powder, spare；Sea cucumber, ginseng, fructus lycii, longan, raspberry, Chinese yam were soaked in water It after night, boils twice, for the first time 8 times of amount water, second of 6 times of amount water is boiled 2 hours for the first time, boiled for the second time 1 hour, merge twice Boil liquid, filtration is added Poria cocos fine powder, is sufficiently mixed Poria cocos fine powder with liquid, bored to set 6 hours, the filling system at 10ml/ bottles Agent, sterilization.

Animal experiment is carried out with said preparation:

Test objective: heart function adjustment effect (ultrasonic cardiography method) of the observation invention formulation to simulated weightlessness rat.

Test method: animal packet and administration rat are randomly divided into 3 groups, respectively the blank group, (letter of tail like chain model group Claim model group), tail like chain model have a drink group (abbreviation beverage group), every group 12.New purchase rat elder generation adaptive feeding is after a week It resettles and hangs tail model.Rat, which is hung on crossbeam, (makes the body of rat incline on key ring, adjusting height immobilization with adhesive tape Oblique 30 ° or so), hind leg can not land, forelimb can 360 ° of ranges move freely；Ad lib, water inlet.Rat dosage in experiment For 0.5ml/kg (being equivalent to equimultiple people quantity), rat will be according to 0.5ml/l00g weight stomach-filling, one time a day.In last Day administration after 1h carry out echocardiography, respectively 9d and 21d evaluation administration after rat cardiac function.Acquire week aroused in interest The data image of phase dynamic image, gained cardiac cycle is stored in CD, is analyzed using VisualSonics system.Index is surveyed It is fixed successively to be measured by LVM type image: LVDD (left ventricular end diastolic dimension), LVPWd (wall thickness after left ventricular end diastolic Degree), LVSD (left ventricular end-systolic dimension), LVPWs (wall thickness after left ventricular contraction latter stage), (left ventricle relaxes LVAWd Open latter stage anterior wall thickness), LVAWs (left ventricular contraction latter stage anterior wall thickness).All measurement numerical value are continuous three weeks aroused in interest The average value of phase.

Test result: left ventricular end-diastolic volume reduction, left room occurs in the rat of model group, and often the amount of fighting is reduced, left room The variations such as diastolic dimensions reduction, illustrate causing the cardiac pumping function of rat and contractile function to have one after 9d hangs tail Determine degree decline.Simulated weightlessness rat after drinking this preparation 9d, left room end-diastolic volume, often fight by left ventricular end diastolic diameter There is the indexs such as wall thickness relatively suspention model group after amount, left ventricular contraction latter stage increases trend, shows that this preparation can be to a certain degree Improve the contraction of simulated weightlessness rat heart, blood-pumping function.

Claims (2)

1. a kind of compound formulation of suitable spacefarer, it is characterised in that: be with sea cucumber, ginseng, fructus lycii, longan, raspberry, Fu Siberian cocklebur, Chinese yam are raw material, are aided with the preparation of xylitol.

2. the compound formulation of suitable spacefarer according to claim 1 a kind of, it is characterised in that: the component raw material weight of said preparation Than as follows:

Sea cucumber 10%-30%

Ginseng 10%~30%

Fructus lycii 5%-20%

Longan 5%~15%

Raspberry 10%~20%

Poria cocos 5%~25%

Chinese yam 5%~25%

Xylitol 1%-5%.