CN1103224C - Chinese patent medicine for treating cold cough and its preparing process - Google Patents
Chinese patent medicine for treating cold cough and its preparing process Download PDFInfo
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- CN1103224C CN1103224C CN00122114A CN00122114A CN1103224C CN 1103224 C CN1103224 C CN 1103224C CN 00122114 A CN00122114 A CN 00122114A CN 00122114 A CN00122114 A CN 00122114A CN 1103224 C CN1103224 C CN 1103224C
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Abstract
The present invention relates to a medicine, particularly to a Chinese patent medicine for treating cold coughs and a preparation method thereof. The medicine is basically prepared from the following components of the proportion by weight: 10 to 50 of ephedra, 10 to 50 of ginger, 10 to 50 of tatarian aster root, 10 to 50 of common coltsfoot flower, 10 to 50 of pro formula pinellia, 10 to 50 of biond magnolia flower, 10 to 50 of siberian cocklebur fruit and 2 to 20 of wild ginger. The present invention has a precise prescription, and medicines bring out the best in each other. Compared with the prior art, the medicine has a great improvement in therapeutic effects; indicated by clinical tests, the medicine has a total effective rate of 96.7% for the treatment of cold coughs, and has the advantages of low dosage of only 5 g per package, short treatment course of 5 days per treatment course and convenient administration by packaged granules.
Description
The present invention relates to a kind of medicine, especially a kind of cold Chinese patent medicine of coughing and preparation method thereof for the treatment of.
Exogenous cough's (being equivalent to acute tracheobronchitis) is a common disease in the illness for lung, the sickness rate height.We have consulted the reported literature of the relevant exogenous cough's Chinese medicine of a piece of writing surplus nearly 15 years 40, analyze, put in order, find among the exogenous cough, wind-cold syndrome accounts for 34.7%, simultaneous occurrence of cold and heat syndromes (mostly being due to the heat transformed from stagnated cold) accounts for 31.4%, and wind-heat syndrome accounts for 25.3%, and wind-dryness syndrome accounts for 8.6%.This shows that the exogenous cough is in the majority with the person of being affected by the cold.Said in Jing-Yue Complete Works as Zhang Jingyue: " six gas all make us coughing, and wind and cold is main ".Cheng Zhongling " Medicine Comprehended " points out emphatically: " cough because of, belong to the wind and cold person, ten occupy its nine ".Especially along with the raising of modern life level of consumption, summer cold air be extensive use of and the supply of cold drink food increases, thereby the exogenous cough since the ratio due to cold (wind) heresy will further rise.
Find that from present medical market investigation treatment exogenous cough's Chinese patent medicine reaches 80 kinds more than, wherein the person is maximum to control the heat syndrome cough, reaches 43 kinds, accounts for 53.8%; Control cough caused by dryness person and take second place, reach 23 kinds, account for 38.8%; Controlling the cough of coldheat complex, is 9 kinds, accounts for 11.2%; Controlling and cold coughing minimumly, only 5 kinds, accounting for 6.2%.
Can find out thus, the cold medicine of coughing of treatment seldom because coldly cough refractory.And existing medicine all exists problems such as weak curative effect, dose many and course of treatment is long.
The object of the present invention is to provide the cold Chinese patent medicine of coughing of a kind of good effect and dose treatment few and short treating period.
Another object of the present invention is to provide the preparation method of this Chinese patent medicine.
For achieving the above object, the present invention is by the following technical solutions:
A kind ofly treat the cold Chinese patent medicine of coughing, it is characterized in that it is made by following components in portion by weight basically: Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 10-50, and Herba Asari is 2-20.
In addition, the reasonable span of the weight proportion of each component is: Herba Ephedrae, Rhizoma Zingiberis Recens,
Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 33-34, and Herba Asari is 10-11.
Originally technology is made electuary or capsule or syrup or unguentum routinely.
The preparation method of this Chinese patent medicine is:
A, Herba Asari and Flos Magnoliae are extracted volatile oil with vapor distillation, device is preserved in addition, and the aqueous solution after distillation device is in addition collected;
B, a operation Chinese medicine slag and Herba Ephedrae, Radix Asteris, Flos Farfarae, Fructus Xanthii four flavors are decocted with water secondary, add 10 times of water gagings for the first time, decocted 1.5 hours, add for the second time 8 times of water gagings, decocted 1 hour, collecting decoction filters, aqueous solution merges among filtrate and a, (the concentrated solution: crude drug), add ethanol and make and contain alcohol amount and reach 65%, standing over night that is concentrated into 1: 1, filter, be condensed into thick paste I behind the filtrate recycling ethanol;
C, with Rhizoma Pinelliae Preparatum and Rhizoma Zingiberis Recens with 70% alcohol reflux secondary, 2 hours for the first time, 1.5 hours for the second time, merge extractive liquid, reclaimed ethanol and also is condensed into thick paste II;
D, merge thick paste I, II, add the volatile oil of gained Herba Asari and Flos Magnoliae in a operation, mixing adds dextrin, Icing Sugar is an amount of, granulation, and drying, packing, promptly.
System side's foundation of we: (one) cough due to wind and cold's basic etiology and pathology is a wind-cold affecting lung, impaired depurative descending of lung QI.Wind and cold two heresies are again primary with cold-evil.Because of cold being a kind of YIN pathogen, the property master holds back spasm with fixed attention, and it is the major reason that causes impaired depurative descending of lung QI that the cold-evil restraints lung, and it is smooth that lung loses a surname, is again to influence the respectful key link of falling of lung qi.Therefore, the loose lung cold, the smooth lung qi of a surname of temperature that link closely is the key point that prescription is selected medicine.(2) exogenous cough belongs to the domination of pathogen more, and when based on eliminating pathogen for dispersing lung-QI, lung qi a surname is logical, and it is coughed from ending.So we are based on eliminating pathogen for dispersing lung-QI, with giving treatment in accordance with the tendency of pathological change, have important ventilatory function, a surname of lung qi is respectful to have close physiological and pathological to concern with the unobstructed of nose key.Clinical experience proves, during the treatment cough due to wind and cold, on the basis of the diffusing lung cold of temperature, adds with a surname's clearing the nasal passage medicine, can not only effectively eliminate the nasal obstruction symptom, and help a surname of lung qi respectful, improves cough suppressing effect.
Side's epheday intermedia, Xin Wen, the kind energy of this product dispersing wind-cold declares smooth lung qi with cough-relieving, has coughed main therapeutical effect at the trembling with fear of affection of exogenous wind-cold inhibited pulmonary QI, so the monarch drug in the side of being.As Compendium of Material Medica said " the special medicine of Herba Ephedrae lung meridian is used it so control pneumonopathy more ".The TAO Hong-Jing Compendium of Material Medica is thought " Herba Ephedrae is cured the wound cold, is expelling pathogenic factors from muscles first medicine ".Rhizoma Zingiberis Recens, Xin Wen has the cold expelling of delivering, the merit of warming the lung to relieve cough." Mingyi Bielu " call its " main typhoid fever, headache nasal obstruction, cough with dyspnea ".Herba Asari, Xin Wen has the merit of expelling wind and cold, warming the lung, a surname's clearing the nasal passage.Compendium of Material Medica is sayed its " the last gas person of cough due to wind and cold should use it ".Rhizoma Zingiberis Recens, Herba Asari principal drug assistance Herba Ephedrae dispersing wind-cold, lung qi dispersing cough-relieving are so be ministerial drug.The Rhizoma Pinelliae, Xin Wen and dry is drying dampness to eliminate phlegm, the key medicine of warming for resolving cold-phlegm." medicine origin " " control cold-phlegm and cold physique drink cold injury lung and coughing ... ".Legal system person can strengthen its merit of reducing phlegm.We use it, and at because of affection of exogenous wind-cold, it is smooth that lung loses a surname, and lung is cloth Tianjin not, and poly-Tianjin becomes expectorant, and the rare main therapeutical effect of accompanied symptoms such as white of the abundant expectoration that expectorant causes from cold transformation is so also be ministerial drug.Radix Asteris, coltsfoot, all hot temperature are gentle lung qi, the product that preventing phlegm from forming and stopping coughing is coughed, so modern whenever share, institute says as " herbal classic is dredged card " more." " a thousand pieces of gold outer platform " all cough with dyspnea chronic cough of controlling, and with Radix Asteris, coltsfoot person ten sides and nine ".Ye Gui a, famous physician of the Qing Dynasty " book on Chinese herbal medicine is new again " has been put down in writing Radix Asteris, and " nourishing the lung to keep the adverse QI downward, cold-phlegm and dyspnea due to deficiency person should it." " medicine origin " meaning coltsfoot " warming the lung antitussive ".This two cooperation Herba Ephedrae, Rhizoma Zingiberis Recens, Herba Asari are strengthened the cold expelling cough-relieving; Cooperate the Rhizoma Pinelliae to strengthen reducing phlegm, so be supplementary drug.The two hot temperature is not dry again, gets the merit of its lung moistening, crosses dry impairing the lung to prevent hot using warming therapy monarch, ministerial drug, so be again supplementary inhibitory medicine.Flos Magnoliae, Fructus Xanthii, all hot temperature all have dispersing wind and cold, the merit of clearing the nasal passage.Nose is the door of lung qi discrepancy, and a surname of nose key is logical, and it is smooth to help lung qi a surname.The two can strengthen monarch, all medicine dispersing wind-cold of minister are declared the effect of smooth lung qi, so also be supplementary drug.We's all flavour of a drug sufferings, warm in nature are gone into lung meridian, and the effect of tying-in is all arranged, so the messenger drug of reuse tying-in not.Make usefulness because of the assistant that Radix Asteris, coltsfoot are arranged, make we's temperature and not dry, so the also messenger drug that need not be in harmonious proportion.Full side cooperates and gathers the merit of expelling wind and cold, lung qi dispersing cough-relieving altogether, thus we to wind-cold affecting lung, lung loses the exogenous cough of a surname due to freely and very is in step with.
The present invention fills a prescription rigorous, and all medicines bring out the best in each other, and compared with prior art, curative effect greatly improves, and shows through clinical trial that treatment is cold and coughs total effective rate and reach 96.7%.And dose is few, and every bag only is 5 grams, short treating period, and 5 days is a course of treatment, packed electuary taking convenience.
Below in conjunction with embodiment the present invention is further elaborated:
Embodiment 1: Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 100 grams, and Herba Asari is 20 grams.Herba Asari and Flos Magnoliae extract volatile oil with vapor distillation, and device is preserved in addition, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Herba Ephedrae, Radix Asteris, Flos Farfarae, Fructus Xanthii four flavors decoct with water secondary, for the first time add 10 times of water gagings, decocted 1.5 hours, add 8 times of water gagings for the second time, decocted 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, (the concentrated solution: crude drug) that is concentrated into 1: 1, add ethanol and make and contain alcohol amount and reach 65%, standing over night is condensed into thick paste I after filtering filtrate recycling ethanol; Surplus medicine Rhizoma Pinelliae Preparatum and Rhizoma Zingiberis Recens are with 70% alcohol reflux secondary, and 2 hours for the first time, 1.5 hours for the second time, merge extractive liquid, reclaimed ethanol and also is condensed into thick paste II.Merge thick paste I, II, add volatile oil such as above-mentioned Herba Asari, mixing, by extractum: dextrin: Icing Sugar is that 4: 3: 3 ratio adds dextrin, Icing Sugar is an amount of, granulation, drying, electuary is made in packing.
Embodiment 2: Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 300 grams, and Herba Asari is 100 grams.Herba Asari and Flos Magnoliae extract volatile oil with vapor distillation, and device is preserved in addition, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Herba Ephedrae, Radix Asteris, Flos Farfarae, Fructus Xanthii four flavors decoct with water secondary, for the first time add 10 times of water gagings, decocted 1.5 hours, add 8 times of water gagings for the second time, decocted 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, (the concentrated solution: crude drug) that is concentrated into 1: 1, add ethanol and make and contain alcohol amount and reach 65%, standing over night is condensed into thick paste I after filtering filtrate recycling ethanol; Surplus medicine Rhizoma Pinelliae Preparatum and Rhizoma Zingiberis Recens are with 70% alcohol reflux secondary, and 2 hours for the first time, 1.5 hours for the second time, merge extractive liquid, reclaimed ethanol and also is condensed into thick paste II.Merge thick paste I, II, add volatile oil such as above-mentioned Herba Asari,, sieve,, cross sieve No. seven, in 60-70 ℃ of oven dry, encapsulated getting final product again with the extractum mixing that dilutes in right amount with ethanol with an amount of calcium carbonate and starch mixing.
Embodiment 3: Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 200 grams, and Herba Asari is 100 grams.Herba Asari and Flos Magnoliae heat up in a steamer extraction volatile oil with steam, and device is preserved in addition, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Herba Ephedrae, Radix Asteris, Flos Farfarae, Fructus Xanthii four flavors decoct with water secondary, for the first time add 10 times of water gagings, decocted 1.5 hours, add 8 times of water gagings for the second time, decocted 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, (the concentrated solution: crude drug) that is concentrated into 1: 1, add ethanol and make and contain alcohol amount and reach 65%, standing over night is condensed into thick paste I after filtering filtrate recycling ethanol; Surplus medicine Rhizoma Pinelliae Preparatum and Rhizoma Zingiberis Recens are with 70% alcohol reflux secondary, and 2 hours for the first time, 1.5 hours for the second time, merge extractive liquid, reclaimed ethanol and also is condensed into thick paste II.Merge thick paste I, II, add volatile oil such as above-mentioned Herba Asari, mixing, other gets sucrose 1500 grams and adds water boil, after the dissolving, filters, and concentrates and makes syrup, with above-mentioned concentrated solution mixing, boils, and puts coldly, adds antiseptic and essence, makes syrup with the cold distilled water dilution.
Embodiment 4: Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 1000 grams, and Herba Asari is 410 grams.Herba Asari and Flos Magnoliae extract volatile oil with vapor distillation, and device is preserved in addition, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Herba Ephedrae, Radix Asteris, Flos Farfarae, Fructus Xanthii four flavors decoct with water secondary, for the first time add 10 times of water gagings, decocted 1.5 hours, add 8 times of water gagings for the second time, decocted 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, (the concentrated solution: crude drug) that is concentrated into 1: 1, add ethanol and make and contain alcohol amount and reach 65%, standing over night is condensed into thick paste I after filtering filtrate recycling ethanol; Surplus medicine Rhizoma Pinelliae Preparatum and Rhizoma Zingiberis Recens are with 70% alcohol reflux secondary, and 2 hours for the first time, 1.5 hours for the second time, merge extractive liquid, reclaimed ethanol and also is condensed into thick paste II.Merge thick paste I, II, add refined honey 1500 gram mixings, filter, put cold rnning and go into volatile oil such as above-mentioned Herba Asari, mixing is made unguentum.
Embodiment 5:
Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 340 grams, and Herba Asari is 100 grams.
Embodiment 6:
Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 336 grams, and Herba Asari is 104 grams.
Embodiment 7:
Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 330 grams, and Herba Asari is 100 grams.
Embodiment 8:
Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 340 grams, and Herba Asari is 110 grams.
Embodiment 9:
Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 100 grams, and Herba Asari is 200 grams.
Embodiment 10:
Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 500 grams, and Herba Asari is 20 grams.
The preparation method that embodiment 5 to 10 adopts is with embodiment 1 to 4.
Claims (7)
1, a kind of Chinese patent medicine of trembling with fear and coughing for the treatment of, it is characterized in that it is that raw material is made by following components in portion by weight basically: Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 10-50, and Herba Asari is 2-20.
2, the cold Chinese patent medicine of coughing of treatment according to claim 1, it is characterized in that it is made by following components in portion by weight basically: Herba Ephedrae, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Flos Magnoliae, Fructus Xanthii respectively are 33-34, and Herba Asari is 10-11.
3, the cold Chinese patent medicine of coughing of treatment according to claim 1 and 2 is characterized in that technology is made electuary or granule routinely.
4, the cold Chinese patent medicine of coughing of treatment according to claim 1 and 2 is characterized in that technology is made capsule routinely.
5, the cold Chinese patent medicine of coughing of treatment according to claim 1 and 2 is characterized in that technology is made syrup routinely.
6, the cold Chinese patent medicine of coughing of treatment according to claim 1 and 2 is characterized in that technology is made unguentum routinely.
7, according to the preparation method of the cold Chinese patent medicine of coughing of treatment as claimed in claim 1 or 2, it is characterized in that:
A. Herba Asari and Flos Magnoliae are extracted volatile oil with vapor distillation, device is preserved in addition, and the aqueous solution after distillation device is in addition collected;
B. a operation Chinese medicine slag and Herba Ephedrae, Radix Asteris, Flos Farfarae, Fructus Xanthii four flavors are decocted with water secondary, add 10 times of water gagings for the first time, decocted 1.5 hours, add for the second time 8 times of water gagings, decocted 1 hour, collecting decoction filters, aqueous solution merges among filtrate and a, be concentrated into the crude drug weight ratio be 1: 1, add ethanol and make and contain alcohol amount and reach 65%, standing over night, filter, be condensed into thick paste I behind the filtrate recycling ethanol;
C. with Rhizoma Pinelliae Preparatum and Rhizoma Zingiberis Recens with 70% alcohol reflux secondary, 2 hours for the first time, 1.5 hours for the second time, merge extractive liquid, reclaimed ethanol and also is condensed into thick paste II;
D. merge thick paste I, II, add the volatile oil of gained Herba Asari and Flos Magnoliae in a operation, mixing adds dextrin, Icing Sugar is an amount of, granulation, and drying, packing, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00122114A CN1103224C (en) | 2000-07-17 | 2000-07-17 | Chinese patent medicine for treating cold cough and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00122114A CN1103224C (en) | 2000-07-17 | 2000-07-17 | Chinese patent medicine for treating cold cough and its preparing process |
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| Publication Number | Publication Date |
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| CN1282597A CN1282597A (en) | 2001-02-07 |
| CN1103224C true CN1103224C (en) | 2003-03-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN00122114A Expired - Lifetime CN1103224C (en) | 2000-07-17 | 2000-07-17 | Chinese patent medicine for treating cold cough and its preparing process |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115919991B (en) * | 2022-12-30 | 2024-04-05 | 江中药业股份有限公司 | Radix asteris cough relieving granule composition and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069412A (en) * | 1991-08-17 | 1993-03-03 | 王延章 | The production method of neoepinephrine |
| CN1225266A (en) * | 1998-02-06 | 1999-08-11 | 王伊斌 | Liquid medicine for treating cold |
-
2000
- 2000-07-17 CN CN00122114A patent/CN1103224C/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069412A (en) * | 1991-08-17 | 1993-03-03 | 王延章 | The production method of neoepinephrine |
| CN1225266A (en) * | 1998-02-06 | 1999-08-11 | 王伊斌 | Liquid medicine for treating cold |
Non-Patent Citations (3)
| Title |
|---|
| 中医杂志1992,33(1) 1993-01-31 王雪华射干麻黄冲剂治疗小儿寒饮咳喘50例疗效观察 * |
| 中医杂志1992,33(1) 1993-01-31 王雪华射干麻黄冲剂治疗小儿寒饮咳喘50例疗效观察;中医杂志1992,33(4) 1992-04-30 洪广祥麻黄的临床运用经验 * |
| 中医杂志1992,33(4) 1992-04-30 洪广祥麻黄的临床运用经验 * |
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| CN1282597A (en) | 2001-02-07 |
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