CN110314106A - A kind of mildy wash and preparation method thereof of containing water-soluble cannabidiol - Google Patents
A kind of mildy wash and preparation method thereof of containing water-soluble cannabidiol Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The invention discloses a kind of mildy wash and preparation method thereof of containing water-soluble cannabidiol.The mildy wash includes following raw material: water-soluble cannabidiol, amino acid surfactant, moisturizer, conditioner, pearling agent, chelating agent, preservative, deionized water.Water solubility cannabidiol of the present invention is main composition, is made of special process, solves cannabidiol water solubility problems, substantially increases the bioavilability of cannabidiol.The mildy wash is by adding suitable water-soluble cannabidiol, so that there is product preferable antibacterial anti-inflammatory, anti-acne the multi-efficiencies such as to releive, is anti-oxidant, and the cleaning force of product is moderate, mild non-stimulated, health environment-friendly.
Description
Technical field
The invention belongs to skin care fields, and in particular to a kind of mildy wash of containing water-soluble cannabidiol and its preparation side
Method.
Background technique
Mildy wash for removing facial excess oil, dirt, cosmetics residue etc., be daily skin care necessary article it
One.Good mildy wash should have both the effect of the protection skin such as cleaning, nutrition, maintenance.It is wound or acne for face to make
The auxiliaring effect that should also have antibacterial anti-inflammatory, anti-acne to releive with crowd, mildy wash.
Hemp also known as fiber crops, Chinese fiber crops, fire fiber crops, mountain silk seedling, jute, have important agricultural, military and medical value.In hemp
Main active cannboid has valuable pharmacological and physiological activity, has separated more than 100 kinds plant source cannboids so far.Greatly
There is the cannabidiol (abbreviation CBD) of rich content antibacterial, anti-inflammatory, anti-acne to releive, is anti-oxidant and to damaging cells in numb element
Repair.
Patent CN107802530A discloses a kind of composition containing Cannador and its application in cosmetics, should
Invention will be formulated by a certain percentage after hemp plant different parts extract combination with cosmetic, be had obviously to bacterium
It kills, inhibiting effect, the active constituent to play a major role is phenolic substances；Patent CN10919851A discloses Cannador
Or Cannador is added directly to different cosmetics and matched by application of the cannabidiol in removal cicatrix of skin, the invention
Fang Zhong.But the more phenolic substances of content such as cannabidiol belongs to fat-soluble compound in hemp, is practically insoluble in water, and face cleaning
It is mostly water in newborn or other cosmetic formulations, directly addition Cannador or cannabidiol can be reduced into auxiliary material
The solubility of effective component, or even effective component CBD is precipitated, to be not easy to be absorbed by the skin, bioavilability is caused to drop
It is low, its effect cannot be given full play to；Patent CN109276491A discloses a kind of clear acne oil-control of foaming certainly containing Cannador
Face cleaning foam and preparation method thereof, the invention in order to improve the solubility of Cannador in formula, using dipropylene glycol and
Decyl glucoside as solubilizer, but chemicals be excessively used it is unfavorable to skin.
Summary of the invention
In view of the above problems and consumer demand, in conjunction with the unique physiological function of cannabidiol, the present invention is utilized
Water-soluble preferable packaging material gets up the cannabidiol embedding of high-purity, improves the solubility of cannabidiol, and then improve its life
Object availability, reduces the use of chemicals solubilizer, and there is mildy wash of the present invention preferable antibacterial anti-inflammatory, anti-acne to releive
Effect, cleaning force is moderate, and safety is made without pair, environmentally protective.
To achieve the above object, the invention adopts the following technical scheme:
(1) a kind of mildy wash of containing water-soluble cannabidiol, is made of the raw material of following weight percent: 0.1%-5% is water-soluble
Cannabidiol, 10%-30% amino acid surfactant, 1%-10% moisturizer, 0.1%-3% conditioner, 0.1%-3% moisturizing grease,
0.1%-2% pearling agent, 0.01%-1% chelating agent, 0.001%-0.1%pH regulator, 0.001%-0.1% preservative, surplus be go from
Sub- water.
Further, the amino acid surfactant is sodium lauroyl sarcosine, sodium lauroyl glutamate, methyl cocoyl
One or more mixtures in acyl taurines sodium, cocaminopropionic acid sodium.
Further, the moisturizer is at least one of glycerol, allantoin, Sodium Hyaluronate.
Further, the conditioner is one of Polyquaternium-10, polyquaternium -52, cation guar gum or more
Kind mixture.
Further, the moisturizing grease is one of olive oil, tea-seed oil, saualane or a variety of mixtures.
Further, the pearling agent is one or both of ethylene glycol monostearate, ethylene glycol double stearate
Mixture.
Further, the chelating agent is disodium ethylene diamine tetraacetate, one or two are mixed in tetrasodium ethylenediamine tetraacetate
Close object.
Further, the preservative is one of sodium benzoate, Phenoxyethanol, potassium sorbate or a variety of mixtures.
Further, the pH adjusting agent can be one or both of citric acid, lactic acid mixture.
(2) method for preparing containing water-soluble cannabidiol mildy wash using above-mentioned composition, comprising the following steps:
S1: dry by required disinfecting utensils.
S2: into reaction kettle plus deionized water, chelating agent, conditioner, stirring obtain solution A to being completely dissolved.
S3: being heated to 70-90 DEG C for solution A, sequentially adds amino acid surfactant, moisturizer, pearling agent, stirring is extremely
It is completely dissolved, obtains solution B.
S4: being cooled to 30-50 DEG C to solution B, and water-soluble cannabidiol, moisturizing grease, preservative, pH adjusting agent is added,
Stirring is cooled to 25 DEG C to being completely dissolved, and adjusts pH value to 5.5-7.0, filtering and discharging is up to mildy wash.
(3) preparation method of the water-soluble cannabidiol includes the following steps: 1. with 2-5 times of ethyl alcohol by high-purity C BD
Dissolution of crystals forms solution；2. 1-5 times of pure water of alpha-cyclodextrin or alcohol-water are dissolved by heating, it is to be dissolved completely after will 1. institute
It states solution to be added thereto, be uniformly mixed；3. including, the solution 1., 2. formed is uniformly mixed, using high pressure homogenization method into
Row cannabidiol inclusion, after, it is concentrated under reduced pressure using Rotary Evaporators, removes most of solvent and moisture；4. it dries, it will 3.
Resulting material is dried in vacuo to get cannabidiol inclusion compound (water solubility).
(4) in the water-soluble cannabidiol cannabidiol 90% or more content.
Compared with prior art, beneficial effects of the present invention:
1, the present invention is preferably wrapped the cannabidiol for being practically insoluble in water under the premise of having not been changed molecular structure with water-soluble
Material gets up the higher CBD embedding of purity, is changed the water solubility of CBD, greatly improves the water solubility and its benefit of CBD
With rate, avoid carrying out solubilising using a large amount of chemicals in formula.
2, water-soluble cannabidiol mildy wash of the present invention can effectively inhibit pathogen, have preferable antibacterial anti-inflammatory,
Anti-acne releives, improves the multi-efficiencies such as allergic reaction, anti-oxidant, and water-soluble cannabidiol is the main function of this product antibacterial anti-acne
Ingredient is imitated, pure plant extracts are belonged to, safety is without side-effects.
3, for the present invention using amino acid surfactant as mildy wash cleansing, cleaning force is moderate, mild non-stimulated,
Biodegradability is good, meets the theory of green and healthy environmental protection.
Specific embodiment
Embodiments of the present invention are described in further detail below with reference to embodiment, following embodiment is merely to illustrate
The present invention, but cannot be used to limit the scope of the invention.
Embodiment 1
(1) preparation of water-soluble cannabidiol
1. accurately weighing 100g cannabidiol solid powder (99% or more purity) and 1L single necked round bottom flask being added in 500g ethyl alcohol
In；Mechanical stirring 30min dissolves cannabidiol solid sufficiently；It is to be dissolved completely after be cooled to room temperature it is spare.
2. accurately weighing 300g alpha-cyclodextrin and 900g level-one purified water being added in 2L single necked round bottom flask, flask is set
In 40 DEG C of water-baths, mechanical stirring 30min is substantially dissolved in alpha-cyclodextrin in water, forms clear solution；It is to be dissolved complete
By step, 1. the solution is added at one time wherein afterwards, continues to stir 10min.
3. including, in 2. mixed liquor merging high pressure homogenizer that step is prepared, starts high-pressure pump, homogenization 3 times, press
Power is 35MPa, 25 DEG C of temperature；High-pressure homogeneous after treatment, is concentrated under reduced pressure using Rotary Evaporators, removes ethyl alcohol and moisture；
Vacuum degree -0.1MPa, temperature 70 C.
4. drying, the crude product that will be formed after concentration, solid mass smashs into powder to pieces, is laid in surface plate, is placed in true
Empty drying box, be dried in vacuo 72h, vacuum degree -0.08MPa, 35 DEG C of temperature.Up to water-soluble cannabidiol.
(2) a kind of mildy wash of containing water-soluble cannabidiol is prepared, steps are as follows:
100 grams of products are prepared, 30 grams of deionized waters, 0.01 gram of EDTA-2Na, 0.1 gram of Polyquaternium-10 is weighed and is added to reaction
In kettle, stirs to being completely dissolved, be then heated to 70 DEG C, 10 grams of sodium lauroyl sarcosines, 1 gram of Sodium Hyaluronate, 0.1 gram are added
Ethylene glycol double stearate, stirring is to being completely dissolved；Be cooled to 50 DEG C to solution, sequentially add 0.1 gram of water-soluble cannabidiol,
0.1 gram of olive oil, 0.001 gram of Phenoxyethanol, 0.001 gram of citric acid, stir evenly, surplus adds deionized water to mend after being completely dissolved
Foot is cooled to 25 DEG C to solution, adjusts pH value to 5.5, filtering and discharging is up to mildy wash.
Embodiment 2
(1) the preparation method is the same as that of Example 1 for water-soluble cannabidiol.
(2) a kind of mildy wash of containing water-soluble cannabidiol is prepared, steps are as follows:
100 grams of products are prepared, 30 grams of deionized waters, 0.1 gram of EDTA-2Na, 0.5 gram of Polyquaternium-10,0.5 gram of cation are weighed
Guar gum is added in reaction kettle, is stirred to being completely dissolved, is then heated to 75 DEG C, 10 grams of sodium lauroyl glutamates, 5 grams are added
Cocaminopropionic acid sodium, 3 grams of glycerol, 2 grams of allantoins, 0.5 gram of ethylene glycol monostearate, stirring is to being completely dissolved；To molten
Liquid is cooled to 45 DEG C, sequentially adds 1 gram of water-soluble cannabidiol, 0.5 gram of olive oil, 0.5 gram of saualane, 0.01 gram of sorbic acid
Potassium, 0.01 gram of lactic acid, stir evenly after being completely dissolved, and surplus adds deionized water to supply, and are cooled to 25 DEG C to solution, adjust pH value extremely
6.0, filtering and discharging is up to mildy wash.
Embodiment 3
(1) the preparation method is the same as that of Example 1 for water-soluble cannabidiol.
(2) a kind of mildy wash of containing water-soluble cannabidiol is prepared, steps are as follows:
100 grams of products are prepared, 30 grams of deionized waters, 0.5 gram of EDTA-4Na, 1 gram of polyquaternium -52,0.5 gram of cationic melon are weighed
You are added in reaction kettle glue, stir to being completely dissolved, are then heated to 80 DEG C, 10 grams of sodium lauroyl glutamates, 10 grams are added
Sodium methyl cocoyl taurate, 3 grams of allantoins, 3 grams of Sodium Hyaluronates, 1 gram of ethylene glycol monostearate are stirred to completely molten
Solution；45 DEG C are cooled to solution, sequentially adds 2.5 grams of water-soluble cannabidiols, 1 gram of tea-seed oil, 1 gram of saualane, 0.05 gram of benzene
Sodium formate, 0.05 gram of citric acid, stir evenly after being completely dissolved, and surplus adds deionized water to supply, and are cooled to 25 DEG C to solution, adjust
PH value is to 6.0, and filtering and discharging is up to mildy wash.
Embodiment 4
(1) the preparation method is the same as that of Example 1 for water-soluble cannabidiol.
(2) a kind of mildy wash of containing water-soluble cannabidiol is prepared, steps are as follows:
100 grams of products are prepared, 30 grams of deionized waters, 0.5 gram of EDTA-4Na, 1 gram of polyquaternium -52,0.5 gram of cationic melon are weighed
You are added in reaction kettle glue, stir to being completely dissolved, are then heated to 85 DEG C, 15 grams of sodium lauroyl sarcosines, 15 grams are added
Sodium methyl cocoyl taurate, 5 grams of glycerol, 5 grams of Sodium Hyaluronates, 1 gram of ethylene glycol double stearate are stirred to completely molten
Solution；35 DEG C are cooled to solution, sequentially adds 4 grams of water-soluble cannabidiols, 1.5 grams of tea-seed oils, 1.5 grams of olive oil, 0.1 gram of benzene
Sodium formate, 0.1 gram of lactic acid, stir evenly after being completely dissolved, and surplus adds deionized water to supply, and are cooled to 25 DEG C to solution, adjust pH
Value is to 6.5, and filtering and discharging is up to mildy wash.
Embodiment 5
(1) the preparation method is the same as that of Example 1 for water-soluble cannabidiol.
(2) a kind of mildy wash of containing water-soluble cannabidiol is prepared, steps are as follows:
100 grams of products are prepared, 30 grams of deionized waters, 1 gram of EDTA-2Na, 3 grams of Polyquaternium-10s is weighed and is added in reaction kettle,
Stirring is then heated to 90 DEG C, it is hard that 30 grams of cocaminopropionic acid sodium, 10 grams of glycerol, 2 grams of ethylene glycol lists is added to being completely dissolved
Resin acid ester, stirring is to being completely dissolved；Be cooled to 35 DEG C to solution, sequentially add 5 grams of water-soluble cannabidiols, 3 grams of saualanes,
0.1 Keshan potassium sorbate, 0.1 gram of citric acid, stir evenly, surplus adds deionized water to supply, and is cooled to solution after being completely dissolved
25 DEG C, adjust pH value to 7.0, filtering and discharging is up to mildy wash.
The antibacterial effect test of the water-soluble cannabidiol mildy wash of embodiment 6
One, experimental material
1, bacterial strain: staphylococcus aureus, Candida albicans, escherichia coli, propionibacterium acnes.
2, test specimen: the product that embodiment 3 is prepared.
Two, experimental method
1, test is by QB/T2738-2012 " evaluation method of daily chemical products antibacterial bacteriostatic effect " 7 .2 antibacterial type daily chemical products
The antibacterial effect method of inspection (suspension quantitative method).
2, in 1:1 (v/v) ratio sterile water dilution test sample, sample after dilution is then taken to act on test organisms
5min, test are repeated 3 times under the conditions of 20 ± 1 DEG C, are averaged.
Three, effect assessment
Sterilizing rate >=90%, product have bactericidal effect；Sterilizing rate >=50%~90%, product have bacteriostasis.
Four, test result
The antibacterial effect of formulation product described in 1 embodiment 3 of table is evaluated
Test result shows that the product has preferable antibacterial effect, the especially antibacterial to the propionibacterium acnes for causing acne
Effect is most obvious.
The anti-acne effect test of the water-soluble cannabidiol mildy wash of embodiment 7
1, study subject: clinical manifestation is that a variety of damages such as papule, warts, tubercle, tumour and scar are presented in face, with face
Skin oil soapy feeling person chooses 100 teenagers with above-mentioned symptom and middle aged men and women as study subject.
2, test specimen: product, the commercially available mildy wash of the preparation of 1 ~ embodiment of embodiment 5.
3, application method: warm water cooperates mildy wash face cleaning, daily each 1 time of morning and evening.
4, anti-acne effect evaluation criteria:
Recovery from illness: symptom completely disappears；
Effective: symptom has clear improvement or improves；
Invalid: symptom is without improvement.
5, according to above-mentioned evaluation criterion, the mildy wash for using embodiment 1 ~ 5 to prepare 100 subjects respectively, 4 months
After count curative effect, statistical result is shown in Table 2.
2 anti-acne curative effect statistical result of table
From table 2 it can be seen that product prepared by the embodiment of the present invention 1 ~ 5 has preferable anti-acne effect.
Integrated embodiment 6 and 7, the mildy wash of the present invention containing cannabidiol have obvious antibacterial, the effect of anti-acne
Fruit.
The foregoing is merely the schematical specific embodiments of the present invention, are not intended to limit the scope of the present invention.
To those skilled in the art, it is all without departing from same embodiment made by the technology of the present invention spirit or change in this hair
Within bright protection scope.
Claims (9)
1. a kind of mildy wash and preparation method thereof of containing water-soluble cannabidiol, the mildy wash by following weight percent original
Material composition: 0.1%-5% water solubility cannabidiol, 10%-30% amino acid surfactant, 1%-10% moisturizer, 0.1%-3% conditioning
Agent, 0.1%-3% moisturizing grease, 0.1%-2% pearling agent, 0.01%-1% chelating agent, 0.001%-0.1%pH regulator, 0.001%-
0.1% preservative, surplus are deionized water.
2. a kind of mildy wash and preparation method thereof of containing water-soluble cannabidiol according to claim 1, which is characterized in that
The surfactant is sodium lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, cocamidopropyl
One or more mixtures in sodium propionate；The moisturizer is one of glycerol, allantoin, Sodium Hyaluronate or a variety of mixing
Object；The conditioner is one of Polyquaternium-10, polyquaternium -52, cation guar gum or a variety of mixtures；It is described
Moisturizing grease is one of olive oil, tea-seed oil, saualane or a variety of mixtures；The pearling agent is ethylene glycol monostearate
One or both of ester, ethylene glycol double stearate mixture；The chelating agent is disodium ethylene diamine tetraacetate, ethylenediamine tetraacetic
One or both of four sodium of acetic acid mixture；The preservative be one of sodium benzoate, Phenoxyethanol, potassium sorbate or
A variety of mixtures；The pH adjusting agent can be one or both of citric acid, lactic acid mixture.
3. a kind of mildy wash and preparation method thereof of containing water-soluble cannabidiol according to claim 1 or 2, feature exists
In described method includes following steps:
S1: dry by required disinfecting utensils；
S2: into reaction kettle plus deionized water, chelating agent, conditioner, stirring obtain solution A to being completely dissolved；
S3: being heated to 70-90 DEG C for solution A, sequentially adds amino acid surfactant, moisturizer, pearling agent, stirs to complete
Dissolution, obtains solution B；
S4: being cooled to 30-50 DEG C to solution B, and water-soluble cannabidiol, moisturizing grease, preservative, pH adjusting agent, stirring is added
To being completely dissolved, 25 DEG C are cooled to, adjusts pH value to 5.5-7.0, filtering and discharging is up to mildy wash.
4. a kind of mildy wash and preparation method thereof of containing water-soluble cannabidiol according to claim 1, which is characterized in that
The preparation method of the water solubility cannabidiol: (1) with 2-5 times ethyl alcohol high-purity C BD dissolution of crystals is formed into solution；(2) will
1-5 times of pure water of alpha-cyclodextrin or alcohol-water dissolve by heating, it is to be dissolved completely after (1) described solution is added thereto, stirring mixes
It closes uniform；(3) it includes, the solution that (1), (2) are formed is uniformly mixed, carry out cannabidiol inclusion, knot using high pressure homogenization method
Shu Hou is concentrated under reduced pressure using Rotary Evaporators, removes most of solvent and moisture；(4) dry, (3) resulting material is carried out true
Sky is dry to get cannabidiol inclusion compound (water solubility).
5. the preparation method of water solubility cannabidiol according to claim 4, which is characterized in that the cannabidiol crystal
99% or more purity requirement.
6. the preparation method of water solubility cannabidiol according to claim 4, which is characterized in that the water solubility hemp two
90% or more the content of cannabidiol in phenol.
7. the preparation method of water solubility cannabidiol according to claim 5, which is characterized in that step (2) pure water
Dosage is 1-5 times of alpha-cyclodextrin quality, and dissolving by heating temperature is 30-60 DEG C.
8. the preparation method of water solubility cannabidiol according to claim 5, which is characterized in that step (3) high pressure
Homogeneous, homogenization 2-3 times, pressure 30-50MPa, 25 DEG C of temperature.
9. the preparation method of water solubility cannabidiol according to claim 5, which is characterized in that step (4) vacuum
Dry, i.e., in a vacuum drying oven, drying time 60-120h, vacuum degree -0.08MPa, temperature are 35-75 DEG C.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917053A (en) * | 2019-12-06 | 2020-03-27 | 辉达生物医药（苏州）有限公司 | Anti-inflammatory composition |
| CN111793979A (en) * | 2020-07-28 | 2020-10-20 | 云南玉麻生物科技有限公司 | Preparation method of functional fabric based on hemp extract |
| EP4054540A4 (en) * | 2019-11-07 | 2023-08-30 | Amyris, Inc. | Compositions and methods for delivering cannabinoids to skin |
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2019
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4054540A4 (en) * | 2019-11-07 | 2023-08-30 | Amyris, Inc. | Compositions and methods for delivering cannabinoids to skin |
| CN110917053A (en) * | 2019-12-06 | 2020-03-27 | 辉达生物医药（苏州）有限公司 | Anti-inflammatory composition |
| CN111793979A (en) * | 2020-07-28 | 2020-10-20 | 云南玉麻生物科技有限公司 | Preparation method of functional fabric based on hemp extract |
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Application publication date: 20191011 |