CN107280987A - A kind of water base prescription of cymene and its application in preparation for external application to skin - Google Patents
A kind of water base prescription of cymene and its application in preparation for external application to skin Download PDFInfo
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- CN107280987A CN107280987A CN201710499362.3A CN201710499362A CN107280987A CN 107280987 A CN107280987 A CN 107280987A CN 201710499362 A CN201710499362 A CN 201710499362A CN 107280987 A CN107280987 A CN 107280987A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
Abstract
The invention discloses a kind of water base prescription of cymene, it is made up of the raw material of following weight parts, 0.01 0.1 parts of cymene, 1.5 20 parts of NMF, 0 7.0 parts of ethanol, 0.01 1.0 parts of solubilizer, prescription solves the problems, such as that cymene tends to precipitation in formula system, the formula is also used as the component in transparent type external medicine preparation or preparation for external application to skin, and stability is good.
Description
Technical field
The invention belongs to medicine, preparation for external application to skin technical field, more particularly to a kind of water base prescription of cymene and its
Application in preparation for external application to skin.
Background technology
The growth of small pox, at present research is induced by anaerobic bacteria, and wherein propionibacterium acnes is to cause small pox
Main bacteria, scytitis can be triggered and explosive infected.The crowd of many people's especially Oilys is by small pox
Puzzlement, has had a strong impact on daily life and doings, therefore, finds a kind of efficient, treatment small pox that stimulation is small, safe
Method tool be of great significance.
O- cymene -5- alcohol (Isopropyl methyphenol, abbreviation IPMP) is a kind of sterilization of safe and efficient stabilization
Preservative, and obtain that FDA approvals are direct or indirect to apply in food, medicine, and cosmetics examination ＆ verification group (CIR) approval makes
In cosmetics, concentration limit value is 0.5%.IPMP can effectively antagonize propionibacterium acnes as antifungal preservative
Breeding, prevent the generation of small pox.CN102905683A discloses composition for processing skin, and it is by polymer and containing-umbrella
The essential oil composition of flower hydrocarbon, with anti-microbial effect.CN201380022102A discloses the cosmetic combinations containing cymene essential oil
Thing, it includes side chain C1-C6 monohydric alcohols, polyalcohol, polyalcohol ethers；Also include at least one thickener, surfactant
Deng.CN201610239262 discloses a kind of skin care compositions with acne-removal function, is by extra large sludge extract, Cortex Phellodendri
Extract, white willow bark extract, glutinous rehmannia extract, Neem extract, Baical Skullcap root P.E, also soybean protein, glycerine Portugal
Glucosides, NMF, emulsifying agent, solubilizer, preservative, water composition.Wherein emulsifying agent is glycol fatty acid ester, solubilizer PEG-
60 rilanit specials, preservative is cymene.Aforementioned patents disclose the preparation for external application to skin that cymene can be used for anti-inflammatory to sterilize
In use, but cymene is added in cosmetics or preparation for external application to skin as acne removing agent or bactericide, with precipitation knot
Brilliant feature tendency, especially the precipitation precipitation and white haze problem of subzero low temperature environment, influence product quality and storage are steady
Qualitative so as to have impact on efficacy exertion, the research currently for this phenomenon is seldom, yet there are no research report.
The content of the invention
In order to solve the above-mentioned technical problem.It is an object of the invention to provide a kind of water base prescription of cymene, the prescription solution
Cymene of having determined tends to precipitation problem in formula system.
It is a further object of the present invention to provide the preparation for external application to skin containing the water base prescription of cymene.
It is a further object of the present invention to provide the external application transparent pharmaceutical preparation containing the water base prescription of cymene.
To achieve the above object, the present invention is achieved through the following technical solutions：
A kind of water base prescription of cymene, it is made up of the raw material of following weight parts：
0.01-0.1 parts of cymene, 1.5-20.0 parts of NMF, 0-7 parts of ethanol, 0.01-1.0 parts of solubilizer.
Further preferably, the described water base prescription of a kind of cymene, it is made up of the raw material of following weight parts：
0.02-0.09 parts of cymene, 7-17.0 parts of NMF, 2-7 parts of ethanol, 0.1-1.0 parts of solubilizer.
Further preferably, the described water base prescription of a kind of cymene, it is made up of the raw material of following weight parts：
0.04-0.06 parts of cymene, 8.0-14 parts of NMF, 5-7 parts of ethanol, 0.2-0.5 parts of solubilizer.
Cymene of the present invention is o- cymene -5- alcohol.
NMF of the present invention is polyalcohol, including but not limited to 1,2-PD, 1,3-PD, 1,3- fourths
One or more combination in glycol, glycerine, PEG-8, polyethylene glycol -32, pungent glycol, preferably more than 3 kinds.
Ethanol of the present invention and NMF polyalcohol etc. are shared, and are enhanced the stability of the water base prescription of cymene, are kept away
Exempt from cryocrystal precipitation, can also be simultaneously as skin sense conditioning agent, enhancing is applicable comfort level.
Solubilizer of the present invention include but is not limited to SOLUBILISANT LRI (PPG-26- butylol polyethers -26,
Cremophor RH40), Cremophor RH40 (HCO-40), PEG-60 rilanit specials (HCO-60), the PPG-13- last of the ten Heavenly stems
Base tetradecyl alchohol polyethers -24 (50MT-2200B), BOLHAN 205 (30% ceteth -20,30% oleth -20,40%
Stereth -20) in one or more combination.
Described SOLUBILISANT LRI, HCO-40, HCO-60,50MT-2200B, BOLHAN 205 is commodity
Name, it is commercially available.
HCO-40 or HCO-60 of the present invention are the nonionic surfactant containing EO, PPG-13- decyls 14
Alcohol polyethers -24 is that polyhydric alcohol polymer has preferably solubilising and stability；BOLHAN 205 is to belong to nonpolar linear fatty alcohol
Polyethers solubilizer, solubilizing effect is better than containing grease polyethers solubilizer.
In some preferred embodiments, the water base prescription of cymene of the invention is made up of following weight parts than raw material, umbrella flower
Hydrocarbon：1,2- propane diols：PEG-8：Polyethylene glycol -32：Pungent glycol：1,3 butylene glycol： LRI：50MT-2200B：BOLHAN
205=0.07:6:1:0.08:1:2:0.2:0.5:0.05.
In some preferred embodiments, the water base prescription of cymene of the invention is made up of following weight parts than raw material, umbrella flower
Hydrocarbon：PEG-8：Pungent glycol：1,3 butylene glycol：1,3- propane diols：LRI： 50MT-2200B：BOLHAN 205=0.05:
2:0.08:1:5:0.3:0.2。
In some preferred embodiments, the water base prescription of cymene of the invention is made up of following weight parts than raw material, umbrella flower
Hydrocarbon：Polyethylene glycol -32：Pungent glycol：1,3 butylene glycol：1,3- propane diols：HCO-40：HCO-60：50MT-2200B=0.09:
1:0.08:5:6:0.2:0.2:0.1。
In some preferred embodiments, the water base prescription of cymene of the invention is made up of following weight parts than raw material, umbrella flower
Hydrocarbon：Glycerine：PEG-8：Polyethylene glycol -32：Pungent glycol：1,3 butylene glycol：1,3- propane diols：BOLHAN 205=
0.02:5:2:2:0.03:1:1:0.6。
In some preferred embodiments, the water base prescription of cymene of the invention is made up of following weight parts than raw material, umbrella flower
Hydrocarbon：Glycerine：1,2- propane diols：PEG-8：Polyethylene glycol -32：Pungent glycol：1,3- propane diols：LRI：HCO-60=
0.03:4:2:3:5:0.05:2:0.1。
In some preferred embodiments, the water base prescription of cymene of the invention is made up of following weight parts than raw material, umbrella flower
Hydrocarbon-：Glycerine：1,2- propane diols：Pungent glycol：1,3 butylene glycol：1,3- propane diols：HCO-60：50MT-2200B=0.04:3:
1:0.1：3:3:0.3:0.2.
In some preferred embodiments, the water base prescription of cymene of the invention is made up of following weight parts than raw material, umbrella flower
Hydrocarbon：Glycerine：1,2- propane diols：Pungent glycol：1,3 butylene glycol：1,3- propane diols：HCO-40： HCO-60：50MT-2200B：
BOLHAN 205=0.05:2:3:0.5:3:4:0.3:0.05:0.2:0.1.
In some preferred embodiments, the water base prescription of cymene of the invention is made up of following weight parts than raw material, umbrella flower
Hydrocarbon：Glycerine：1,2- propane diols：PEG-8：1,3 butylene glycol：1,3- propane diols：HCO-60=0.05:1:5:5:4:5:
0.3。
The water base prescription of cymene of the present invention can be used for including but not limited to cymene external medicine preparation and external preparation for skin system
In the formula of agent, it accounts for formulation weight percentage for 1-20%.For example transparent disinfectant of the external medicine preparation etc..It is described to contain umbrella
The flower water base prescription disinfectant of hydrocarbon has sterilizing effect.
The preparation for external application to skin of the water base prescription of the present invention containing cymene is transparent type product, and is made with anti-inflammatory anti-acne
With.The preparation for external application to skin includes but is not limited to cosmetics, articles for use of washing one's face, shower cream, hair shampoo article etc., preferably makes up
Product.
Preparation for external application to skin of the present invention, it is made up of the raw material of following weight percentage：
The water base prescription 1.52-21.1% of cymene
Skin conditioning agent 0.01-11.0%
Preservative 0.2-1.0%
Complexing agent 0-0.3%
Essence 0.001-0.3%
The water of surplus.
Further preferably, preparation for external application to skin of the present invention, it is made up of the raw material of following weight percentage
The water base prescription 8.12-18.09% of cymene
Skin conditioning agent 0.15-5%
Preservative 0.4-0.9%
Complexing agent 0.01-0.3%
Essence 0.005-0.1%
The water of surplus.
Further preferably, preparation for external application to skin of the present invention, it is made up of the raw material of following weight percentage
The water base prescription 12.4-6.4% of cymene
Skin conditioning agent 0.3-10%
Preservative 0.5-0.7%
Complexing agent 0.05-0.1%
Essence 0.005-0.05%
The water of surplus.
Skin conditioning agent described in foregoing invention be dipotassium glycyrrhizinate, pot marigold extract solution, chamomile extract solution, niacinamide,
One or more in vitamin B6.It is preferred that skin conditioning agent is pot marigold extract solution, chamomile extract solution, dipotassium glycyrrhizinate conjunction
With its weight ratio is (50-1):(50-1):(1-3), still more preferably, its weight ratio are (50-1)：(50-1):1.
The dipotassium glycyrrhizinate, pot marigold extract solution, chamomile extract solution are commercially available or are prepared according to prior art.
The preservative is the one or more in Phenoxyethanol, Sensiva SC50, sodium benzoate, methyl hydroxybenzoate.
The complexing agent is the one or more in EDTA2 sodium, sodium phytate, calgon, with anti-corrosion synergistic effect.
Compared with prior art, the present invention has the advantages that：
1st, the present invention has found in screening process, and cymene individually coordinates with NMF polyalcohol (mass number 20%)
There is crystallization precipitation in (25 DEG C, 15 DEG C, -18 DEG C) under different temperatures, situation after polyalcohol consumption (mass number 40%) is increased
Improved, but still separated out at -18 DEG C of low temperature, only rely on polyalcohol, it is impossible to solve the precipitation of o- cymene -5- alcohol
Problem.General character contains EO nonionic surfactant such as HCO-40 or HCO- during cymene and solubilizer compatibility mechanism
60 its exclusive use, all can not be solubilized well by IPMP, and PPG-13- decyl tetradecyl alcohols polyethers -24 gathers for the polyalcohol of representative
Compound, is used alone, and gathers in the preferably solubilized stability of 25 DEG C and 5 DEG C performances, same component containing PPG-26- butanol
The LRI of ether -26 shows as fabulous stability；It is representative with BOLHAN 205, belongs to the increasing of nonpolar linear aliphatic alcohol polyether
Solvent, solubilizing effect is better than containing grease polyethers solubilizer.But (25 DEG C, 15 DEG C, -18 DEG C) are crystallized at a temperature of
Separate out, it is seen that rely solely on solubilizer, it is impossible to solve the problems, such as IPMP precipitation, it is necessary to consider that other compositions help solubilized IPMP.It is single
Found in one NMF and single solubilizer assigning process, the compatibility of NMF solubilizer is also selective, such as when 1,
Ammediol respectively with LRI, HCO-40, HCO-60,50MT-2200B, BOLHAN 205) compounding when, 1,3-PD and water shape
Into continuous phase, the ability with solubilized O- cymenes -5- alcohol, this temperature section (25 DEG C, 15 DEG C) shows as helping solvability.And
In extreme temperature conditions (- 18 DEG C), IPMP problems of dissolution is not improved, reason is probably nonionic surfactant especially alkane
Hydrocarbon chain hydrophobic group is stronger, there is self-assemble all the more, and the addition of 1,3-PD, reduces micellar structure water, entropy energy
Increase, micella is unstable, it is impossible to solubilized IPMP, is allowed to tend to separate out.Only BOLHAN 205 is compounded with 1,3- propane diols and solved
Low temperature separates out problem.By substantial amounts of screening process, unexpected a variety of NMF and the solubilizer compoundings of the present invention could solve low
Warm precipitation problem.The water base component of cymene that NMF and solubilizer are compounded composition by inventor according to a certain percentage first, energy
It is enough to solve the problems, such as that the cymene aqueous solution is opaque very well and have a precipitation, the precipitation problem especially under subzero extreme temperature, surely
Set is pellucidity all the time.
2nd, inventor has found to increase ethanol consumption on the basis of the water base component of above-mentioned cymene again, can further improve umbrella
The stability of the water base component of flower hydrocarbon, pellucidity is remained in that even in more low temperature, when increasing ethanol, accordingly reduces NMF
Consumption, while having skin sense comfort level.
3rd, when being used for transparent aqua using the water base prescription of cymene (such as toner), due to addition preservative, effect
The materials such as agent, electrolyte, these factors can influence the stability of aqua, cause cymene to separate out, and inventor is had found by adding
Big a certain proportion of NMF and solubilizer consumption or increase ethanol, then avoid the influence low temperature that foregoing preservatives etc. are brought
Do not separate out, be always maintained at pellucidity, no precipitation and precipitation.
4th, for industrialization cost analysis, NMF polyalcohol price is higher than ethanol, and adding a small amount of ethanol can be reduced
NMF polyalcohol consumption can be realized as the goal of the invention of the present invention, therefore ethanol replaces partial amounts for industrialization
Polyalcohol reduction production cost be with beneficial effect.
In a word, the present invention provides a kind of solution of solution o- cymene -5- alcohol tending to separate out in transparent water-based formula system
Certainly scheme, it is transparent without precipitation with keeping stability of the o- cymene -5- alcohol in formula system, especially zero degrees celsius with
Lower low-temperature stability is good, thereby guarantees that the efficacy exertion of o- cymene -5- alcohol, and anti-acne bactericidal effect is notable.
In order to more protrude beneficial effects of the present invention, illustrated by following test examples
The dissolving of test example one, aqua preparation for external application to skin component to the -5- of cymene containing o- alcohol in transparent water agent prescription
Stability influence
Specific experiment method is as follows：
Precise B phases raw material (being weighed according to the prescription amount corresponding mass percentage of table 1), can heat that (60 DEG C are helped at room temperature
Dissolving), stop heating after B phased solns are transparent, add A phases raw material (being weighed according to the formula ratio corresponding mass percentage of table 1), stir
Mix the uniform room temperature that is cooled to and transparent aqua be made, investigate the steady dissolution phenomenon at 48 DEG C, 40 DEG C, 25 DEG C, 5 DEG C, -18 DEG C,
Period of supervision 3 months.
Steady dissolutions of the IPMP of table 1 in transparent water agent prescription
Note：√:Dissolve transparent, no precipitation
It can be seen from the transparent aqua prescription that table 1 is designed when IPMP amounts be about 0.05%, influence IPMP dissolving because
Element may be from polyalcohol species, preservative, skin conditioning agent, complexing agent, electrolyte etc..By table 4 (prescription 1), opposed polarity
Polyalcohol compounding, it is good to IPMP solubilizing effect compared to single polyalcohol 1,3-PD, especially low temperature separate out problem obtain
To solve；Table 1 (prescription 1, prescription 2) is contrasted, and is added after preservative MP, and formula mist occurs in vain, continuously adds PE9010 (table 1, group
3) there is knot cream precipitation in 5 DEG C and -18 DEG C of low temperature for side, illustrates that MP and PE9010 has certain solubilising with o- cymene -5- alcohol
Competitive relation.Table 1 (prescription 4) adds electrolyte sodium chloride, can obviously improve mist in vain, and improves the precipitation phenomenon of 5 DEG C of low temperature, but
- 18 DEG C of extreme low temperature is not improved.Table 1 (prescription 5 and embodiment 3) phenomenon is contrasted, while improving PEG-400 and 1,3-BG
Amount, can accomplish transparent without precipitation, illustrate that the amount for improving polyalcohol can solve the steady dissolution of low temperature；(the prescription 6 of table 1
With embodiment 3) phenomenon contrast, solubilizer 50MT-2200B, and HCO-60 compoundings are added, can accomplish transparent without precipitation, explanation
Solubilizer is compounded, solubilizer total amount is improved, the stability of dissolution in low temperature can also be solved.When under the conditions of extremely low temperature for example-
30 DEG C, appearance is slightly separated out in -18 degrees Celsius of prescriptions, but after ethanol is added, even if prescription does not still have under extremely low temperature
There is precipitation, it is seen that ethanol has synergy to the water base prescription of the present invention, the crystal for reducing pole low temperature environment is separated out.
The water base preparation for external application to skin stability test of test example two, cymene
The water base preparation for external application to skin of cymene of the present invention：Embodiment 1-8
The water base preparation for external application to skin 1-3 of comparative example：Precise B phases raw material is (according to the formula ratio corresponding mass of table 2 at room temperature
Percentage is weighed), (60 DEG C of hydrotropy solutions) can be heated, stops heating after B phased solns are transparent, A phases raw material is added and (matches somebody with somebody according to table 2
Side's amount corresponding mass percentage is weighed), stir and be cooled to room temperature, investigate molten at 48 DEG C, 40 DEG C, 25 DEG C, 5 DEG C, -18 DEG C
Numerical solution phenomenon, period of supervision 3 months.
Assay method：The water base preparation for external application to skin of cymene and comparative example 1-3 prepared by embodiment 1~8 is stored respectively
In 48 DEG C, 40 DEG C, insulating box preservation condition, 5 DEG C, -18 DEG C, 3 under the conditions of refrigerator cold-storage condition, room temperature (25 DEG C, shady and cool ventilation)
Individual month, observe its appearance color, whether be layered, mist is white, discoloration etc..
As a result show：Be shown in Table 3, the water base preparation for external application to skin of anti-acne of Fig. 1-3 present invention 48 DEG C, 40 DEG C, 25 DEG C, 5
DEG C, -18 DEG C preserve 3 months, appearance stablity, separates out situation at no discoloration, illustrate that the water base preparation for external application to skin of anti-acne of the present invention has
There is good stability.
The water base preparation for external application to skin comparative example of table 2- cymene -5- alcohol separates out prescription
The appearance stability of table 3
The raw material and equipment of the present invention is commercially available.SOLUBILISANT LRI purchases from gloomy fragrant essence pigment science and technology (in
State) Co., Ltd；BOLHAN 205 (30% ceteth -20,30% oleth -20,40% stereth -20)
Commercially available, manufacturer comes from S.BlACK, and Britain is bought by Guangzhou Pin Sheng trade Co., Ltds；Pot marigold extract solution is commercially available, purchase
Buy from the naturally vigorous and graceful Co., Ltd of a Japanese ball；Chamomile extract solution is commercially available, buys from the naturally vigorous and graceful limited public affairs of a Japanese ball
Department.
Brief description of the drawings
The water base preparation for external application to skin transparent picture of Fig. 1 cymenes of the present invention
The white haze picture that Fig. 2 comparative examples 2 of the present invention occur
Fig. 3 cymenes of comparative example 3 of the present invention separate out picture
Embodiment
Below in conjunction with the accompanying drawings, the embodiment to the present invention is described in detail, it is to be understood that the guarantor of the present invention
Shield scope is not limited by embodiment.
The water base preparation for external application to skin of embodiment 1-8o- cymene -5- alcohol
Formula is as shown in table 4：
The o- water base preparation for external application to skin of cymene -5- alcohol of table 4 is without precipitation prescription
The preparation method of the water base preparation for external application to skin of above-mentioned o- cymenes -5- alcohol, comprises the following steps：
1) A phases are principal phase, and A phases normal-temperature water first is added into main cooker, add A phase remaining components, and control stirring does not start water
Flower, is heated to 80~85 DEG C, is incubated 15min, it is ensured that A phased solns completely, and supplement loss water no more than 1%, and stirring is cooled to
40-45℃。
2) B heat phases are to 50 DEG C, and premix dissolving, is cooled to 40-45 DEG C in advance.C phases are added, premix stirring is homogeneous, adds
Main cooker, then D phase raw materials are separately added into, control stirring does not start spray, it is ensured that material body is homogeneous.
3) stirring is cooled to 35 ± 2 DEG C of dischargings, detects qualified rear discharging.
It is foregoing to the present invention specific illustrative embodiment description be in order to illustrate and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, can be much changed
And change.The purpose of selecting and describing the exemplary embodiment is that explaining that the certain principles and its reality of the present invention should
With so that those skilled in the art can realize and using the present invention a variety of exemplaries and
A variety of selections and change.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (10)
1. a kind of water base prescription of cymene, it is made up of the raw material of following weight parts：0.01-0.1 parts of cymene, NMF 1.5-
20.0 parts, 0-7 parts of ethanol, 0.01-1.0 parts of solubilizer.
2. a kind of water base prescription of cymene as claimed in claim 1, it is made up of the raw material of following weight parts：Cymene
0.02-0.09 parts, 7-17.0 parts of NMF, 2-7 parts of ethanol, 0.1-1.0 parts of solubilizer.
3. a kind of water base prescription of cymene as claimed in claim 1, it is made up of the raw material of following weight parts：Cymene
0.04-0.06 parts, 8.0-14 parts of NMF, 5-7 parts of ethanol, 0.2-0.5 parts of solubilizer.
4. the water base prescription of cymene as described in claim 1-3 any one, it is characterised in that：Described cymene is o- umbrellas
Flower hydrocarbon -5- alcohol；Described NMF is 1,2-PD, 1,3-PD, 1,3-BDO, glycerine, PEG-8, poly- second
One or more combination in glycol -32, pungent glycol；Described solubilizer is that SOLUBILISANT LRI, PEG-40 hydrogenate castor
One or more combination in sesame oil, PEG-60 rilanit specials, PPG-13- decyl tetradecyl alcohols polyethers -24, BOLHAN 205.
5. the water base prescription of cymene as claimed in claim 4 is used as transparent type external medicine preparation or preparation for external application to skin formula
One of component.
6. the water base prescription preparation for external application to skin as claimed in claim 5 containing cymene, it is by following materials by weight percentage
It is made：
The water base prescription 1.52-21.0% of cymene
Skin conditioning agent 0.01-11.0%
Preservative 0.2--1.0%
Complexing agent 0-0.3%
Essence 0.001-0.3%
The water of surplus.
7. the water base prescription preparation for external application to skin as claimed in claim 6 containing cymene, it is by following materials by weight percentage
It is made：
The water base prescription 8.12-18.09% of cymene
Skin conditioning agent 0.15-5%
Preservative 0.4-0.9%
Complexing agent 0.01-0.3%
Essence 0.005-0.1%
The water of surplus.
8. the water base prescription preparation for external application to skin as claimed in claim 7 containing cymene, it is by following materials by weight percentage
It is made：
The water base prescription 12.4-6.4% of cymene
Skin conditioning agent 0.3-10%
Preservative 0.5-0.7%
Complexing agent 0.05-0.1%
Essence 0.005-0.05%
The water of surplus.
9. the water base prescription skin care item containing cymene as described in claim 6-8 any one, it is characterised in that described skin care
Also include Shu Min agent, functional additive, electrolyte in product preparation for external application to skin.
10. the water base prescription preparation for external application to skin containing cymene as described in claim 6-8 any one, it is characterised in that institute
The skin conditioning agent stated is one kind in dipotassium glycyrrhizinate, pot marigold extract solution, chamomile extract solution, niacinamide, vitamin B6
Or it is several.
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| CN201710499362.3A CN107280987A (en) | 2017-06-27 | 2017-06-27 | A kind of water base prescription of cymene and its application in preparation for external application to skin |
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| CN201710499362.3A CN107280987A (en) | 2017-06-27 | 2017-06-27 | A kind of water base prescription of cymene and its application in preparation for external application to skin |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108524327A (en) * | 2018-05-25 | 2018-09-14 | 珠海伊斯佳科技股份有限公司 | A kind of shower cream and preparation method thereof |
| CN110215404A (en) * | 2019-07-12 | 2019-09-10 | 广州汇朗无纺制品有限公司 | Liquid cymene and its preparation method and application |
| CN111214421A (en) * | 2020-03-17 | 2020-06-02 | 广东芭薇生物科技股份有限公司 | Double-layer moisturizing essence and preparation method thereof |
| CN111789795A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Hand sanitizer with liposome-encapsulated bactericidal component and preparation method thereof |
| CN114948805A (en) * | 2021-02-23 | 2022-08-30 | 上海昆药生物科技有限公司 | Antibacterial composition containing sweet wormwood herb volatile oil and application of antibacterial composition in acne-removing skin care product |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108524327A (en) * | 2018-05-25 | 2018-09-14 | 珠海伊斯佳科技股份有限公司 | A kind of shower cream and preparation method thereof |
| CN110215404A (en) * | 2019-07-12 | 2019-09-10 | 广州汇朗无纺制品有限公司 | Liquid cymene and its preparation method and application |
| CN110215404B (en) * | 2019-07-12 | 2022-07-05 | 广州汇朗生物科技有限公司 | Liquid cymene and preparation method and application thereof |
| CN111214421A (en) * | 2020-03-17 | 2020-06-02 | 广东芭薇生物科技股份有限公司 | Double-layer moisturizing essence and preparation method thereof |
| CN111214421B (en) * | 2020-03-17 | 2022-03-11 | 广东芭薇生物科技股份有限公司 | Double-layer moisturizing essence and preparation method thereof |
| CN111789795A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Hand sanitizer with liposome-encapsulated bactericidal component and preparation method thereof |
| CN114948805A (en) * | 2021-02-23 | 2022-08-30 | 上海昆药生物科技有限公司 | Antibacterial composition containing sweet wormwood herb volatile oil and application of antibacterial composition in acne-removing skin care product |
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