CN110302258A - A kind of Chinese medicinal material extract and preparation method thereof with antiobesity action - Google Patents
A kind of Chinese medicinal material extract and preparation method thereof with antiobesity action Download PDFInfo
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- CN110302258A CN110302258A CN201910669860.7A CN201910669860A CN110302258A CN 110302258 A CN110302258 A CN 110302258A CN 201910669860 A CN201910669860 A CN 201910669860A CN 110302258 A CN110302258 A CN 110302258A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The Chinese medicinal material extract and preparation method thereof with antiobesity action that the invention discloses a kind of, raw material include: the cauline leaf of himalayan prinsepia leaf spray；Preparation method includes the following steps that step 1, raw material is chosen；Step 2, pretreatment of raw material；Step 3, raw material parch；Step 4, raw material are rubbed；Step 5, raw material drying；Step 6, extract preparation；The Chinese medicinal material extract and preparation method thereof with antiobesity action, himalayan prinsepia leaf extract prepare it is simple and easy, it is low in cost；According to C57BL/6J Experimental model of small mice it is found that can effectively reduce obese mouse weight；The obesity mice body fat content of high fat diet induction can be reduced；The obesity mice blood lipid level of high fat diet induction can effectively be adjusted；It is horizontal that LPL, PL in obesity mice serum can effectively be adjusted；Adipose tissue hyperplasia can be improved, the Chinese medicinal material extract with significant antiobesity action can be used as the raw material of slimming drug, health care product or food, and obese people is helped to drop light weight, reduce body fat.
Description
Technical field
The present invention relates to the big health industry technical field of biological medicine, specially a kind of Chinese medicine with antiobesity action is mentioned
Take object and preparation method thereof.
Background technique
As dietary structure change and improvement of living standard, the quantity of obese people are continuously increased, according to world health group
Investigation is knitted, 2016, the whole world had more than 1,900,000,000 adult overweight, more than 6.5 hundred million people's obesities.Annual at least 2,800,000 people's death can return
It censures in overweight or fat.The problem of obesity was once considered as high-income countries, and low income and middle income country are also extensive now
There are problems that this.Obesity not only will affect the image appearance of people, and be often accompanied by Abnormality of Glycolipid Metabolism, also will increase and suffers from sugar
The risk for urinating the epidemic diseases such as disease, hypertension, coronary heart disease, hyperlipidemia, has become global public health problem, because
This fat treatment becomes the hot spot paid close attention to both at home and abroad.Drug therapy is fat one of the conventional means of current treatment, is answered now
Chemical classes slimming medicine is broadly divided into three classes: appetite inhibitor (sibutramine), digest and assimilate retarding agent (orlistat),
Increase energy consumption medicine (hormone).These drugs block the formation of fat by indirect mode, usually companion while obtaining curative effect
Side effect and drug dependence, fat rebound after drug withdrawal.Chinese medicine and natural drug have resourceful, integration of drinking and medicinal herbs, poison secondary
It acts on small, drug effect and mitigates the advantages such as lasting, also carried out more fat-reducing and antihyperglycemic research at present, such as hawthorn, the coptis, ginseng
Saponin(e, cortex cinnamomi, aloe, cactus, Radix Curcumae, Radix Astragali, oyster mushroom, yacon, weeping willow leaf etc. have been reported that prompt is from Chinese medicine or naturally
The substance that adipose tissue can safely and effectively be reduced by seeking in drug still has biggish potentiality.
Himalayan prinsepia leaf Prinsepia utilis Royle is the machaka of rosaceae Lee subfamily Prinsepia Royle, the flat core of alias
Wood, bayonet fruit, fruit of buying oil (Qujing), passion fruit (Yunnan) etc., are grown on 1000~3000 meters of height above sea level of mountain by 1~5 meter of plant height
In slope, small stream side or bushes, Winter blooming, summer as a result, monoecism, is mainly distributed Yunnan, Guizhou, Sichuan, Tibet etc.
Ground, Pakistan, Nepal, Bhutan and north India are also distributed.Yunnan Province Kunming, Dali, Lijing, Wei Xi, Ning Lang,
The counties such as Simao, Nan Jian, Wei Shan, Binchuan are distributed.First recorded in " the southern regions of the Yunnan Province book on Chinese herbal medicine ", it says himalayan prinsepia leaf: " property cold dispelling, bitter.Attack one
Sore ulcer is cut, has purulence to lift one's head, no purulence is vertical to disappear；Dissipating bind core, chews and is carefully taken with wine；Its root, stem, leaf, fruit can be used as medicine, and our province is received
Western race, Bai nationality, the Yi nationality, distributed over Yunnan, Sichuan and Guizhou, the applicating history for having more than one thousand years in Mo Suo Zu Deng ethnic group ".Himalayan prinsepia leaf " Guizhou Chinese herbal medicine ",
It is also on the books in " dictionary of medicinal plant ".Himalayan prinsepia leaf cauline leaf cures mainly ulcer carbuncle, acute toothache, bullet wound, fracture, snake bite.2005
Year himalayan prinsepia leaf has been used as Chinese medicine to be embodied in " Yunnan Province's Chinese medicine standard ", standard No. [YNZYC-0185-2007], modern medicine
Reason studies have shown that himalayan prinsepia leaf has the effects that anti-inflammatory, antitumor, immunosupress, hypoglycemic, anti-oxidant, inhibition platelet aggregation.
In domestic and international relevant report, do not find that it has the research of antiobesity action.
Summary of the invention
The Chinese medicinal material extract and preparation method thereof with antiobesity action that the purpose of the present invention is to provide a kind of, to solve
The problems mentioned above in the background art.
In order to solve the above technical problem, the present invention provides following technical solutions: a kind of Chinese medicine with antiobesity action
Extract, raw material include: the cauline leaf on himalayan prinsepia leaf spray.
A kind of preparation method of the Chinese medicinal material extract with antiobesity action, includes the following steps, step 1, raw material choosing
It takes；Step 2, pretreatment of raw material；Step 3, raw material parch；Step 4, raw material are rubbed；Step 5, raw material drying；Step 6,
Extract preparation；
Wherein in the above step 1, the cauline leaf on selection himalayan prinsepia leaf spray and appropriate amount of purified water are spare；
Wherein in above-mentioned steps two, cauline leaf is removed into floating ash, worm's ovum or yellow leaf, using warm water it is clean after dry it is standby
With；
Wherein in above-mentioned steps three, cleaned cauline leaf is subjected to parch using parcher, is curled until cauline leaf is heated；
Wherein in above-mentioned steps four, the cauline leaf after parch is sufficiently rubbed using rolling machine, is answered during rubbing
It is primary when solving or turning in rub barrel；
Wherein in above-mentioned steps five, the cauline leaf rubbed is utilized into heated-air drying, remains its dry tack free without juice；
Wherein in above-mentioned steps six, extract preparation the following steps are included:
It 1) will be spare after the himalayan prinsepia leaf cauline leaf progress coarse crushing after drying；
2) will pure water be added extraction vessel in as extract solution, using soxhlet extraction extract to
1g/ml is prepared into himalayan prinsepia leaf extract.
According to the above technical scheme, the cauline leaf on the himalayan prinsepia leaf spray is current year raw fresh cauline leaf.
According to the above technical scheme, in the step 2, warm water used is 30-45 DEG C of pure water.
According to the above technical scheme, in the step 3, the parch temperature of parcher is 250-300 DEG C, and parch revolving speed is
40-50 revs/min, the parch time is 5-8 minutes.
According to the above technical scheme, in the step 4, rolling machine can be selected the wooden hand push rolling machine of six or four formula of Anxi or
35 type electric kneading machine of Fujian tea, 10 jin or so of the every barreled leaf amount of the wooden hand push rolling machine of six or four formula of Anxi, revolving speed 40-50
Rev/min, time of kneading 4-6 minutes, revolution 180-240 turned；35 type electric kneading machine of Fujian tea, 14-16 jins of every barreled leaf amount, revolving speed
60 turns per minute, time of kneading 3-5 minutes.
According to the above technical scheme, in the step 5, hot blast temperature is 40-45 DEG C, and drying time is 10-15 minutes.
According to the above technical scheme, in the step 6, the weight ratio for extracting solution and himalayan prinsepia leaf cauline leaf is 10:1.
According to the above technical scheme, in the step 6, after the completion of extract preparation, C57BL/6J male mice fertilizer is established
Fat model: C57BL/6J male mice is randomly divided into normal control, hyperlipidemia model, positive controls (Orlistat120mg/
Kg), himalayan prinsepia leaf high dose group, himalayan prinsepia leaf middle dose group, himalayan prinsepia leaf low dose group；Normal group detoxification conventional feed,
Hyperlipidemia model and each administration group detoxification high lipid food, establish fat animal model；After modeling 4 weeks, take Normal group and
Whether hyperlipidemia model group animal, measurement mouse adipose content, weight, confirmation obese model form.
According to the above technical scheme, after modeling success, successive administration 5 weeks, by measuring mouse weight, Lee's index, work
Mouse component analysis technology detects fat, moisture, Lean mass, OLYMPUS CKX41 Intelligent Laser scanning confocal microscope and sees
Examine fat cell morphology and fat cell cross-sectional area, lipoprotein lipase (LPL) in detection serum, pancreatic lipase contain
Amount organizes interior and comparison among groups all data, the antiobesity action of the himalayan prinsepia leaf of evaluation.
According to the above technical scheme, it is screened with key gene of the Real-time quantitative PCR to fat metabolism access,
Obese mouse belly fat tissue is removed, the change of HSL, ATGL, TGH, DGAT, PPARy, C5L2, Lep mrna expression amount is detected
Change, inquire into the molecular mechanism of action of himalayan prinsepia leaf weight-reducing, confirms action target spot.
Compared with prior art, the beneficial effects obtained by the present invention are as follows being: this has the Chinese medicinal material extract of antiobesity action
And preparation method thereof, himalayan prinsepia leaf extract prepare it is simple and easy, it is low in cost；According to C57BL/6J Experimental model of small mice it is found that can
Obese mouse weight is effectively reduced；The obesity mice body fat content of high fat diet induction can be reduced；High fat diet can effectively be adjusted
The obesity mice blood lipid level of induction；It is horizontal that LPL, PL in obesity mice serum can effectively be adjusted；The invention can improve fat
Tissue hyperplasia, the Chinese medicinal material extract with significant antiobesity action, can be used as the raw material of slimming drug, health care product or food,
It helps obese people to lose weight, reduces body fat.
Detailed description of the invention
Attached drawing is used to provide further understanding of the present invention, and constitutes part of specification, with reality of the invention
It applies example to be used to explain the present invention together, not be construed as limiting the invention.In the accompanying drawings:
Fig. 1 is that step of the invention founds flow chart；
Fig. 2 is flow chart of the invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The present invention provides a kind of technical solution referring to FIG. 1-2: a kind of Chinese medicinal material extract with antiobesity action, former
Material includes: the cauline leaf on himalayan prinsepia leaf spray.
A kind of preparation method of the Chinese medicinal material extract with antiobesity action, includes the following steps, step 1, raw material choosing
It takes；Step 2, pretreatment of raw material；Step 3, raw material parch；Step 4, raw material are rubbed；Step 5, raw material drying；Step 6,
Extract preparation；
Wherein in the above step 1, the cauline leaf on selection himalayan prinsepia leaf spray and appropriate amount of purified water are spare；
Wherein in above-mentioned steps two, cauline leaf is removed into floating ash, worm's ovum or yellow leaf, is cleaned using 30-45 DEG C of warm water dry
It is dried after net spare；
Wherein in above-mentioned steps three, cleaned cauline leaf is subjected to parch using parcher, is curled until cauline leaf is heated,
The parch temperature of parcher is 250-300 DEG C, and parch revolving speed is 40-50 revs/min, and the parch time is 5-8 minutes；
Wherein in above-mentioned steps four, the cauline leaf after parch is sufficiently rubbed using rolling machine, is answered during rubbing
Primary when solving or turning in rub barrel, 35 type electric kneading of the wooden hand push rolling machine of six or four formula of Anxi or Fujian tea can be selected in rolling machine
Twister, 10 jin or so of the every barreled leaf amount of the wooden hand push rolling machine of six or four formula of Anxi, revolving speed are 40-50 revs/min, time of kneading 4-
6 minutes, revolution 180-240 turned；35 type electric kneading machine of Fujian tea, 14-16 jins of every barreled leaf amount, are rubbed by 60 turns per minute of revolving speed
Time 3-5 minute；
Wherein in above-mentioned steps five, the cauline leaf rubbed is utilized into heated-air drying, remains its dry tack free without juice,
Hot blast temperature is 40-45 DEG C, and drying time is 10-15 minutes；
Wherein in above-mentioned steps six, extract preparation the following steps are included:
It 1) will be spare after the himalayan prinsepia leaf cauline leaf progress coarse crushing after drying；
2) will pure water be added extraction vessel in as extract solution, using soxhlet extraction extract to
1g/ml is prepared into himalayan prinsepia leaf extract, and the weight ratio for extracting solution and himalayan prinsepia leaf cauline leaf is 10:1.
Wherein, the cauline leaf on himalayan prinsepia leaf spray is current year raw fresh cauline leaf.
Embodiment 1:
After himalayan prinsepia leaf extract feeds mouse 1 week, compared with model group, administration group mouse weight is steady, not significant to increase,
And weight is below model group, P < 0.05.Compared with positive group, administration group weight is above positive group, and closes in concentration-effect
System, wherein high dose group weight and positive group difference are smaller.The result shows that himalayan prinsepia leaf extract can effectively reduce obesity mice body
Weight.
Embodiment 2:
After himalayan prinsepia leaf extract feeds mouse 2 weeks, compared with model group, high dose group body fat content is significantly reduced, and P <
0.05, himalayan prinsepia leaf extract feeds P < 0.01 after mouse 3 weeks.Administration group mouse body fat growth rate is below model group, as a result
Show that himalayan prinsepia leaf extract can reduce the obesity mice body fat content of high fat diet induction.
Embodiment 3:
After himalayan prinsepia leaf extract feeds mouse 5 weeks, compared with model group, obesity mice Lees index is significantly reduced, wherein
Low dose group Lees index reduces not significant, P > 0.05.Compared with positive group, high dose group reduces slightly, no statistical difference
Meaning, P > 0.05 prompt the himalayan prinsepia leaf extract fat reducing effect of the dosage close with positive drug.Pharmaceutical intervention group Lees index becomes
Change curve and positive group is consistent, and there are concentration-effect relations, the results showed that himalayan prinsepia leaf extract is reduced fatty effect.
Embodiment 4:
After himalayan prinsepia leaf extract feeds mouse 5 weeks, compared with model group and positive group, the HDL-C level liter of obesity mice
Height, LDL-C, TG, TC level reduce, and change curve and positive group are consistent, and concentration-effect relation is presented, the results showed that green
Puncture tip extract can effectively adjust the obesity mice blood lipid level of high fat diet induction.
Embodiment 5:
After himalayan prinsepia leaf extract feeds mouse 5 weeks, compared with model group and positive group, LPL, PL in administration group mice serum
Content has different degrees of raising, and it is in concentration-effect relation that change curve and positive group are consistent；The result shows that himalayan prinsepia leaf
It is horizontal that extract can effectively adjust LPL, PL in obesity mice serum.
Embodiment 6:
After himalayan prinsepia leaf extract feeds mouse 5 weeks, compared with the model group and positive group, fat cell volume is different degrees of
Change, high dose group with the positive group fat cell volume be obviously reduced, the results showed that himalayan prinsepia leaf extract can improve fat
Tissue hyperplasia.
Embodiment 7:
After himalayan prinsepia leaf extract feeds mouse 5 weeks, compared with model group, each gene mRNA changes of contents has conspicuousness poor
Different, P < 0.01, wherein ATGL, C5L2, HSL, Leptin, TGH mRNA level in-site significantly raise, and DGAT, PPAR γ mRNA level in-site are aobvious
It writes and lowers；Compared with positive group, pharmaceutical intervention group can effectively adjust 7 gene mRNA levels, change curve and positive drug
Unanimously, and concentration-effect relation is presented, wherein the above 7 gene mRNA levels abilities of high dose group adjusting are suitable with positive drug,
P > 0.05, the results showed that the himalayan prinsepia leaf extract of high dose can effectively adjust ATGL, C5L2, DGAT, HSL, Leptin, PPAR
The mRNA level in-site of γ, TGH adjust fat metabolism level in Mice Body with this, realize antiobesity action.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (8)
1. a kind of Chinese medicinal material extract with antiobesity action, it is characterised in that: raw material includes: the spray cauline leaf of himalayan prinsepia leaf.
2. a kind of preparation method of the Chinese medicinal material extract with antiobesity action, includes the following steps, step 1, raw material is chosen；
Step 2, pretreatment of raw material；Step 3, raw material parch；Step 4, raw material are rubbed；Step 5, raw material drying；Step 6 is extracted
Object preparation；It is characterized by:
Wherein in the above step 1, the cauline leaf on selection himalayan prinsepia leaf spray and appropriate amount of purified water are spare；
Wherein in above-mentioned steps two, cauline leaf is removed into floating ash, worm's ovum or yellow leaf, using warm water it is clean after dry it is spare；
Wherein in above-mentioned steps three, cleaned cauline leaf is subjected to parch using parcher, is curled until cauline leaf is heated；
Wherein in above-mentioned steps four, the cauline leaf after parch is sufficiently rubbed using rolling machine, it should be during rubbing
It solves or turns in rub barrel and is primary；
Wherein in above-mentioned steps five, the cauline leaf rubbed is utilized into heated-air drying, remains its dry tack free without juice；
Wherein in above-mentioned steps six, extract preparation the following steps are included:
It 1) will be spare after the himalayan prinsepia leaf cauline leaf progress coarse crushing after drying；
2) pure water is added in extraction vessel as solution is extracted, is extracted using soxhlet extraction to 1g/ml, is prepared into green thorn
Sharp extract.
3. a kind of Chinese medicinal material extract with antiobesity action according to claim 1, it is characterised in that: the himalayan prinsepia leaf
Cauline leaf on spray is current year raw fresh cauline leaf.
4. a kind of preparation method of Chinese medicinal material extract with antiobesity action according to claim 2, it is characterised in that:
In the step 2, warm water used is 30-45 DEG C of pure water.
5. a kind of preparation method of Chinese medicinal material extract with antiobesity action according to claim 2, it is characterised in that:
In the step 3, the parch temperature of parcher is 250-300 DEG C, and parch revolving speed is 40-50 revs/min, and the parch time is 5-8 points
Clock.
6. a kind of preparation method of Chinese medicinal material extract with antiobesity action according to claim 2, it is characterised in that:
In the step 4,35 type electric kneading machine of the wooden hand push rolling machine of six or four formula of Anxi or Fujian tea, Anxi six is can be selected in rolling machine
10 jin or so of the every barreled leaf amount of the wooden hand push rolling machine of four formulas, revolving speed be 40-50 revs/min, time of kneading 4-6 minutes, revolution
180-240 turns；35 type electric kneading machine of Fujian tea, 14-16 jins of every barreled leaf amount, 60 turns per minute of revolving speed, time of kneading 3-5 points
Clock.
7. a kind of preparation method of Chinese medicinal material extract with antiobesity action according to claim 2, it is characterised in that:
In the step 5, hot blast temperature is 40-45 DEG C, and drying time is 10-15 minutes.
8. a kind of preparation method of Chinese medicinal material extract with antiobesity action according to claim 2, it is characterised in that:
In the step 6, the weight ratio for extracting solution and himalayan prinsepia leaf cauline leaf is 10:1.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103931829A (en) * | 2014-03-03 | 2014-07-23 | 曲靖会丰生物科技开发有限公司 | Prinsepia utilis Royle tea preparation method |
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2019
- 2019-07-24 CN CN201910669860.7A patent/CN110302258A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103931829A (en) * | 2014-03-03 | 2014-07-23 | 曲靖会丰生物科技开发有限公司 | Prinsepia utilis Royle tea preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 李艳萍等: "民族药青剌尖茶减肥作用的研究思路探讨", 《中国民族医药学会药品临床评价分会2016年学术年会》 * |
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