CN110300804B - 通过胶束催化合成dna缀合物的方法 - Google Patents

通过胶束催化合成dna缀合物的方法 Download PDF

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Publication number
CN110300804B
CN110300804B CN201880012015.6A CN201880012015A CN110300804B CN 110300804 B CN110300804 B CN 110300804B CN 201880012015 A CN201880012015 A CN 201880012015A CN 110300804 B CN110300804 B CN 110300804B
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dna
small organic
molecule
reaction
micelle
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Chinese (zh)
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CN110300804A (zh
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A·S·哈特
斯科皮克 M·科利卡
A·布伦施韦格
R·韦伯斯基
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Technische Universitaet Dortmund
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Technische Universitaet Dortmund
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201880012015.6A 2017-02-14 2018-02-14 通过胶束催化合成dna缀合物的方法 Expired - Fee Related CN110300804B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17156047.7 2017-02-14
EP17156047.7A EP3360962A1 (en) 2017-02-14 2017-02-14 Synthesis of dna-encoded libraries by micellar catalysis
PCT/EP2018/053650 WO2018149863A1 (en) 2017-02-14 2018-02-14 Method for the synthesis of dna conjugates by micellar catalysis

Publications (2)

Publication Number Publication Date
CN110300804A CN110300804A (zh) 2019-10-01
CN110300804B true CN110300804B (zh) 2024-02-02

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US (1) US11407993B2 (https=)
EP (2) EP3360962A1 (https=)
JP (1) JP7094029B2 (https=)
CN (1) CN110300804B (https=)
WO (1) WO2018149863A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021067399A1 (en) * 2019-10-03 2021-04-08 Atomwise Inc. Systems and methods for screening compounds in silico
CN112831843A (zh) * 2019-11-22 2021-05-25 成都先导药物开发股份有限公司 一种一锅法On-DNA铃木反应方法
GB202103343D0 (en) 2021-03-11 2021-04-28 Univ Newcastle Micellar catalysis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007048423A1 (en) * 2005-10-26 2007-05-03 Stichting Dutch Polymer Institute Unimolecular micelles containing metal nanoparticles and their use as catalyst for synthesis of carbon-carbon-bonds
WO2010118471A1 (en) * 2009-04-17 2010-10-21 The University Of Queensland Reactor and method for performing a chemical reaction
CN103998658A (zh) * 2011-09-07 2014-08-20 X-化学有限公司 用于标记dna-编码文库的方法

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JPS5529525A (en) 1978-08-21 1980-03-01 Hidetoshi Tsuchida Metal complex of hydrophilic and hydrophobic block copolymer
JPS55144048A (en) 1979-04-27 1980-11-10 Hidetoshi Tsuchida Coordination high polymeric metal complex composition for adsorption-desorption of oxygen
JP2002345460A (ja) 2001-03-23 2002-12-03 Fuji Photo Film Co Ltd 修飾触媒及びそれを用いた反応器並びに防汚樹脂組成物
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
NZ560962A (en) 2005-02-18 2011-12-22 Surface Logix Inc Methods of making pharmacokinetically improved compounds using sarcosine functional residues or groups and pharmaceutical compositions comprising said compounds
EP1972349A1 (en) * 2007-03-21 2008-09-24 Biocompatibles UK Limited GLP-1 fusion peptides conjugated to polymer(s), their production and use
US20110281934A1 (en) * 2008-11-06 2011-11-17 Phaserx, Inc. Micelles of hydrophilically shielded membrane-destabilizing copolymers
WO2010091144A1 (en) * 2009-02-04 2010-08-12 Wake Forest University Health Sciences Compositions, methods, and kits for identifying candidate molecules from encoded chemical libraries
WO2014071361A1 (en) 2012-11-05 2014-05-08 Rubicon Genomics Barcoding nucleic acids
EP3184674A1 (en) 2015-12-23 2017-06-28 Technische Universität Dortmund Dna-encoded chemical library, use thereof and method to synthesize the library

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007048423A1 (en) * 2005-10-26 2007-05-03 Stichting Dutch Polymer Institute Unimolecular micelles containing metal nanoparticles and their use as catalyst for synthesis of carbon-carbon-bonds
WO2010118471A1 (en) * 2009-04-17 2010-10-21 The University Of Queensland Reactor and method for performing a chemical reaction
CN103998658A (zh) * 2011-09-07 2014-08-20 X-化学有限公司 用于标记dna-编码文库的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Accelerating Strain-Promoted Azide-Alkyne Cycloaddition Using Micellar Catalysis;Grant I Anderton et al.;《Bioconjug Chem》;20150609;第26卷(第8期);摘要，第1687页右栏最后一段-1688页左栏倒数第2段，第1688页右栏最后一段-1689页左栏第1段，1689页右栏倒数第2段 *
Heck and Suzuki coupling reactions in water using poly(2-oxazoline)s functionalized with palladium carbene complexes as soluble, amphiphilic polymer supports;DanielSchonfelder et al.;《Journal of Organometallic Chemistry》;20051101;第690卷(第21-22期);摘要，第4649页左栏第2段。第4650页左栏第2段-右栏第1段，第4652页右栏第2-3段，第4654页右栏第2段 *

Also Published As

Publication number Publication date
EP3583211B1 (en) 2024-04-10
EP3360962A1 (en) 2018-08-15
WO2018149863A1 (en) 2018-08-23
EP3583211A1 (en) 2019-12-25
US11407993B2 (en) 2022-08-09
CN110300804A (zh) 2019-10-01
JP2020507346A (ja) 2020-03-12
US20220002712A1 (en) 2022-01-06
JP7094029B2 (ja) 2022-07-01

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